ORMDL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.20445083
2telomere maintenance via semi-conservative replication (GO:0032201)3.98685777
3protein prenylation (GO:0018342)3.93790323
4prenylation (GO:0097354)3.93790323
5telomere maintenance via recombination (GO:0000722)3.90927397
6DNA strand elongation involved in DNA replication (GO:0006271)3.87839783
7iron-sulfur cluster assembly (GO:0016226)3.75761783
8metallo-sulfur cluster assembly (GO:0031163)3.75761783
9DNA strand elongation (GO:0022616)3.72476474
10platelet dense granule organization (GO:0060155)3.68938329
11mitotic recombination (GO:0006312)3.64273975
12protein neddylation (GO:0045116)3.61682090
13preassembly of GPI anchor in ER membrane (GO:0016254)3.56366354
14DNA double-strand break processing (GO:0000729)3.55665736
15water-soluble vitamin biosynthetic process (GO:0042364)3.41805726
16base-excision repair, AP site formation (GO:0006285)3.36785126
17proteasome assembly (GO:0043248)3.36670449
18negative regulation of T cell receptor signaling pathway (GO:0050860)3.35847888
19respiratory chain complex IV assembly (GO:0008535)3.35410501
20GPI anchor metabolic process (GO:0006505)3.27696550
21GPI anchor biosynthetic process (GO:0006506)3.25474399
22DNA replication initiation (GO:0006270)3.25186587
23CENP-A containing nucleosome assembly (GO:0034080)3.22625784
24negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.19293064
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18367835
26cytochrome complex assembly (GO:0017004)3.18095660
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16328856
28protein complex biogenesis (GO:0070271)3.13755662
29regulation of T cell receptor signaling pathway (GO:0050856)3.13077669
30DNA demethylation (GO:0080111)3.08673652
31cytidine metabolic process (GO:0046087)3.06518415
32cytidine catabolic process (GO:0006216)3.06518415
33cytidine deamination (GO:0009972)3.06518415
34DNA deamination (GO:0045006)3.04863691
35chromatin remodeling at centromere (GO:0031055)3.04681381
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04326464
37purine nucleobase biosynthetic process (GO:0009113)3.02885638
38cullin deneddylation (GO:0010388)3.02707824
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99751833
40telomere maintenance via telomere lengthening (GO:0010833)2.97030144
41DNA unwinding involved in DNA replication (GO:0006268)2.96169303
42protein deneddylation (GO:0000338)2.96013816
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93412474
44deoxyribonucleotide biosynthetic process (GO:0009263)2.92003215
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90288631
46nucleotide-excision repair, DNA gap filling (GO:0006297)2.89245254
47mannosylation (GO:0097502)2.88514634
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88224100
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87261681
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87249294
51mitochondrial respiratory chain complex assembly (GO:0033108)2.86757179
52nucleobase biosynthetic process (GO:0046112)2.86276416
53pyrimidine ribonucleoside catabolic process (GO:0046133)2.85823643
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85290017
55formation of translation preinitiation complex (GO:0001731)2.84351479
56regulation of mitotic spindle checkpoint (GO:1903504)2.83054168
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83054168
58negative regulation of DNA-dependent DNA replication (GO:2000104)2.82723363
59regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.82442769
60C-terminal protein lipidation (GO:0006501)2.80697472
61DNA replication-independent nucleosome assembly (GO:0006336)2.80211879
62DNA replication-independent nucleosome organization (GO:0034724)2.80211879
63antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78554507
64maturation of SSU-rRNA (GO:0030490)2.77846657
65mitochondrial respiratory chain complex I assembly (GO:0032981)2.77783254
66NADH dehydrogenase complex assembly (GO:0010257)2.77783254
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77783254
68negative regulation of telomere maintenance (GO:0032205)2.77661639
69DNA replication checkpoint (GO:0000076)2.76915984
70eosinophil chemotaxis (GO:0048245)2.73169013
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72964953
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72757994
73establishment of protein localization to mitochondrial membrane (GO:0090151)2.72181250
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71425606
75regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.70229046
76ATP synthesis coupled proton transport (GO:0015986)2.69795994
77energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69795994
78regulation of RIG-I signaling pathway (GO:0039535)2.69530581
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.69530411
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.69530411
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69146912
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69146912
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69146912
84peptidyl-histidine modification (GO:0018202)2.66169335
85DNA integration (GO:0015074)2.65118795
86cell wall macromolecule metabolic process (GO:0044036)2.63521111
87telomere organization (GO:0032200)2.63463426
88regulation of cellular amino acid metabolic process (GO:0006521)2.62972114
89telomere maintenance (GO:0000723)2.62880243
90viral mRNA export from host cell nucleus (GO:0046784)2.62591915
91chaperone-mediated protein transport (GO:0072321)2.62415708
92C-terminal protein amino acid modification (GO:0018410)2.62131765
93respiratory electron transport chain (GO:0022904)2.61050021
942-deoxyribonucleotide biosynthetic process (GO:0009265)2.60762327
95deoxyribose phosphate biosynthetic process (GO:0046385)2.60762327
96DNA dealkylation (GO:0035510)2.60579070
97protein-cofactor linkage (GO:0018065)2.59960118
98regulation of B cell receptor signaling pathway (GO:0050855)2.59641391
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.59184311
100ubiquinone biosynthetic process (GO:0006744)2.59136562
101histone mRNA metabolic process (GO:0008334)2.58920389
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58832850
103signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58587304
104signal transduction involved in DNA damage checkpoint (GO:0072422)2.58587304
105hepatocyte apoptotic process (GO:0097284)2.57484153
106electron transport chain (GO:0022900)2.56232158
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.56226486
108termination of RNA polymerase III transcription (GO:0006386)2.56226486
109kinetochore organization (GO:0051383)2.55337647
110ubiquinone metabolic process (GO:0006743)2.55226231
111eosinophil migration (GO:0072677)2.52929687
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.52392891
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52085304
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51583216
115IMP metabolic process (GO:0046040)2.51285292
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49705069
117negative regulation of ligase activity (GO:0051352)2.49705069
118seminiferous tubule development (GO:0072520)2.45004546
119transcription-coupled nucleotide-excision repair (GO:0006283)2.44139195
120antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.44108941
121viral transcription (GO:0019083)2.43580221
122signal peptide processing (GO:0006465)2.43158385
123ribosomal small subunit biogenesis (GO:0042274)2.41676859
124deoxyribonucleotide catabolic process (GO:0009264)2.40559293
125negative T cell selection (GO:0043383)2.39159901
126translational termination (GO:0006415)2.38300641
127activated T cell proliferation (GO:0050798)2.37263092
128L-fucose catabolic process (GO:0042355)2.35689172
129fucose catabolic process (GO:0019317)2.35689172
130L-fucose metabolic process (GO:0042354)2.35689172
131nucleoside salvage (GO:0043174)2.35442429
132pyrimidine nucleotide catabolic process (GO:0006244)2.35412648
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.35398036
134phosphorylated carbohydrate dephosphorylation (GO:0046838)2.34861335
135inositol phosphate dephosphorylation (GO:0046855)2.34861335
136meiotic chromosome segregation (GO:0045132)2.34809961
137G1/S transition of mitotic cell cycle (GO:0000082)2.34787818
138cell cycle G1/S phase transition (GO:0044843)2.34787818
139SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.34771707
140necroptotic process (GO:0070266)2.34391932
141positive regulation of B cell differentiation (GO:0045579)2.32900693
142tryptophan metabolic process (GO:0006568)2.32576938
143tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.31854768
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.31854768
145negative regulation of fibroblast apoptotic process (GO:2000270)2.31080481
146pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.31029630
147B cell mediated immunity (GO:0019724)2.31016163
148spliceosomal snRNP assembly (GO:0000387)2.30960268
149purine-containing compound salvage (GO:0043101)2.28317799
150cotranslational protein targeting to membrane (GO:0006613)2.27738446
151deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.26906458
152kinetochore assembly (GO:0051382)2.26356403
153histone exchange (GO:0043486)2.26001539
154IMP biosynthetic process (GO:0006188)2.25952830
155pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.24109095
156protein targeting to ER (GO:0045047)2.23336042
157sequestering of actin monomers (GO:0042989)2.22847266
158translational elongation (GO:0006414)2.21917693
159positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.21620856
160regulation of B cell differentiation (GO:0045577)2.20707013
161immunoglobulin mediated immune response (GO:0016064)2.20223823
162DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.19214884
163negative regulation of phagocytosis (GO:0050765)2.18051800
164positive regulation of granulocyte differentiation (GO:0030854)2.17967342
165DNA catabolic process, exonucleolytic (GO:0000738)2.17845637
166response to interferon-beta (GO:0035456)2.17645667
167protein localization to endoplasmic reticulum (GO:0070972)2.17517397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81830256
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90042557
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.23764774
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23520727
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19599639
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18388463
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.00475587
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.98822708
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.92396947
10ZNF274_21170338_ChIP-Seq_K562_Hela2.83168429
11VDR_22108803_ChIP-Seq_LS180_Human2.82096331
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73058640
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62196480
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52261674
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51841497
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46879531
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44430848
18IGF1R_20145208_ChIP-Seq_DFB_Human2.43561354
19* FLI1_27457419_Chip-Seq_LIVER_Mouse2.37830800
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29808015
21VDR_23849224_ChIP-Seq_CD4+_Human2.27293127
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26683342
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.25648885
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18780878
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17131835
26HOXB4_20404135_ChIP-ChIP_EML_Mouse2.15960448
27* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13667300
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12908393
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09370291
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.06078002
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02281943
32FOXP3_21729870_ChIP-Seq_TREG_Human2.00640565
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00253435
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00106011
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99413372
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96324762
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94787737
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93973104
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93738162
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.91905499
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88489323
42ELK1_19687146_ChIP-ChIP_HELA_Human1.87927903
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.86390102
44EWS_26573619_Chip-Seq_HEK293_Human1.84815554
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82863194
46* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82673259
47DCP1A_22483619_ChIP-Seq_HELA_Human1.78234916
48TAF15_26573619_Chip-Seq_HEK293_Human1.78033738
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77223668
50XRN2_22483619_ChIP-Seq_HELA_Human1.76578431
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75963762
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.74967509
53FUS_26573619_Chip-Seq_HEK293_Human1.73406512
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70667768
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.68178088
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66158467
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66154003
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64053055
59GATA1_22025678_ChIP-Seq_K562_Human1.63150074
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.63067885
61* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62741827
62AR_21909140_ChIP-Seq_LNCAP_Human1.60282646
63GABP_19822575_ChIP-Seq_HepG2_Human1.59957021
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.59804210
65SPI1_23547873_ChIP-Seq_NB4_Human1.59705159
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54401477
67IRF1_19129219_ChIP-ChIP_H3396_Human1.54255924
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52419798
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.51650200
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45780203
71CIITA_25753668_ChIP-Seq_RAJI_Human1.45714771
72SCL_19346495_ChIP-Seq_HPC-7_Human1.43193651
73P300_19829295_ChIP-Seq_ESCs_Human1.42430330
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41320327
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.39662241
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37431757
77TTF2_22483619_ChIP-Seq_HELA_Human1.37414144
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34870509
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34507801
80* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33612783
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33387873
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33106835
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32738283
84GATA3_26560356_Chip-Seq_TH2_Human1.30374129
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29064732
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28355919
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28317784
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28049726
89* NFE2_27457419_Chip-Seq_LIVER_Mouse1.27034414
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.26010672
91* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25589436
92* EZH2_27294783_Chip-Seq_NPCs_Mouse1.25544572
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24252651
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23663494
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21244596
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21184779
97ER_23166858_ChIP-Seq_MCF-7_Human1.20503522
98TP53_22573176_ChIP-Seq_HFKS_Human1.19205925
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19056191
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17893720
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17855602
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.16702939
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16051104
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15730647
105GBX2_23144817_ChIP-Seq_PC3_Human1.15376508
106TFEB_21752829_ChIP-Seq_HELA_Human1.14144689
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13356650
108MYC_22102868_ChIP-Seq_BL_Human1.11211207
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10922892
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10518814
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10111548
112RXR_22158963_ChIP-Seq_LIVER_Mouse1.09969933
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08862363
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.08143866
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08025091
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07610649
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.07610649
118STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07484228
119MYC_18940864_ChIP-ChIP_HL60_Human1.07042593
120* AR_20517297_ChIP-Seq_VCAP_Human1.06868236
121BCAT_22108803_ChIP-Seq_LS180_Human1.05343515
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03410542
123CBP_20019798_ChIP-Seq_JUKART_Human1.03029889
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03029889
125* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02729171
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02506900
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02415448
128SOX2_19829295_ChIP-Seq_ESCs_Human1.02345722
129NANOG_19829295_ChIP-Seq_ESCs_Human1.02345722
130MYB_26560356_Chip-Seq_TH2_Human1.02255000
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01830718
132KDM5A_27292631_Chip-Seq_BREAST_Human1.01172331
133* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00832068
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00112457
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99130068
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98572754
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95686570
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94074788
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93250244
140MYB_26560356_Chip-Seq_TH1_Human0.93066118
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92642362
142GATA3_26560356_Chip-Seq_TH1_Human0.92450065
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91549973
144* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91357646
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91234624
146NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91111688
147HTT_18923047_ChIP-ChIP_STHdh_Human0.90688074
148GATA3_27048872_Chip-Seq_THYMUS_Human0.90673799
149NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90626620
150KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89787566
151RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89765254
152* P53_22387025_ChIP-Seq_ESCs_Mouse0.89487525
153* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89476346
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88784547
155RUNX1_22412390_ChIP-Seq_EML_Mouse0.87988723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.33232163
2MP0001835_abnormal_antigen_presentation3.06159610
3MP0006072_abnormal_retinal_apoptosis2.78661736
4MP0008057_abnormal_DNA_replication2.74189577
5MP0003693_abnormal_embryo_hatching2.72483918
6MP0002396_abnormal_hematopoietic_system2.69143745
7MP0009697_abnormal_copulation2.62661060
8MP0010094_abnormal_chromosome_stability2.59861014
9MP0002102_abnormal_ear_morphology2.50483998
10MP0008058_abnormal_DNA_repair2.44487087
11MP0005671_abnormal_response_to2.41086714
12MP0002139_abnormal_hepatobiliary_system2.37031528
13MP0009785_altered_susceptibility_to2.30785513
14MP0005085_abnormal_gallbladder_physiolo2.25999366
15MP0005360_urolithiasis2.19471580
16MP0003077_abnormal_cell_cycle2.13508761
17MP0004957_abnormal_blastocyst_morpholog2.07891997
18MP0003186_abnormal_redox_activity2.06385025
19MP0001986_abnormal_taste_sensitivity2.05972777
20MP0005253_abnormal_eye_physiology2.05794718
21MP0005075_abnormal_melanosome_morpholog2.04681514
22MP0008007_abnormal_cellular_replicative2.03532557
23MP0002166_altered_tumor_susceptibility1.97637139
24MP0003111_abnormal_nucleus_morphology1.93534483
25MP0005365_abnormal_bile_salt1.90539476
26MP0003763_abnormal_thymus_physiology1.90429668
27MP0002132_abnormal_respiratory_system1.88439136
28MP0000685_abnormal_immune_system1.87206786
29MP0003787_abnormal_imprinting1.81429351
30MP0003436_decreased_susceptibility_to1.80013775
31MP0003880_abnormal_central_pattern1.79033062
32MP0009333_abnormal_splenocyte_physiolog1.77481971
33MP0001800_abnormal_humoral_immune1.73181108
34MP0004142_abnormal_muscle_tone1.72455651
35MP0001764_abnormal_homeostasis1.72305470
36MP0005025_abnormal_response_to1.69355958
37MP0006054_spinal_hemorrhage1.67696113
38MP0002398_abnormal_bone_marrow1.65741149
39MP0000490_abnormal_crypts_of1.61478243
40MP0008995_early_reproductive_senescence1.59057087
41MP0001529_abnormal_vocalization1.57271662
42MP0002006_tumorigenesis1.56892260
43MP0005551_abnormal_eye_electrophysiolog1.56015050
44MP0008875_abnormal_xenobiotic_pharmacok1.54775004
45MP0002452_abnormal_antigen_presenting1.53683111
46MP0005084_abnormal_gallbladder_morpholo1.53648028
47MP0000689_abnormal_spleen_morphology1.53605534
48MP0003656_abnormal_erythrocyte_physiolo1.53096211
49MP0005464_abnormal_platelet_physiology1.52726703
50MP0001984_abnormal_olfaction1.51537758
51MP0008789_abnormal_olfactory_epithelium1.50988877
52MP0002723_abnormal_immune_serum1.47779472
53MP0002722_abnormal_immune_system1.47518829
54MP0002420_abnormal_adaptive_immunity1.46240071
55MP0001819_abnormal_immune_cell1.45400025
56MP0000465_gastrointestinal_hemorrhage1.44946459
57MP0002148_abnormal_hypersensitivity_rea1.44895742
58MP0002419_abnormal_innate_immunity1.43516059
59MP0001790_abnormal_immune_system1.43039194
60MP0005387_immune_system_phenotype1.43039194
61MP0002277_abnormal_respiratory_mucosa1.40454111
62MP0005000_abnormal_immune_tolerance1.40421891
63MP0001545_abnormal_hematopoietic_system1.39585459
64MP0005397_hematopoietic_system_phenotyp1.39585459
65MP0000716_abnormal_immune_system1.37851928
66MP0002429_abnormal_blood_cell1.37243763
67MP0006082_CNS_inflammation1.37197664
68MP0004782_abnormal_surfactant_physiolog1.36602465
69MP0009046_muscle_twitch1.35726411
70MP0001919_abnormal_reproductive_system1.35153775
71MP0005389_reproductive_system_phenotype1.34788049
72MP0002751_abnormal_autonomic_nervous1.33841332
73MP0006035_abnormal_mitochondrial_morpho1.32364717
74MP0006292_abnormal_olfactory_placode1.29699269
75MP0003786_premature_aging1.27959148
76MP0001853_heart_inflammation1.24985408
77MP0004808_abnormal_hematopoietic_stem1.24464331
78MP0008469_abnormal_protein_level1.18608060
79MP0001845_abnormal_inflammatory_respons1.16094252
80MP0005645_abnormal_hypothalamus_physiol1.15694646
81MP0010155_abnormal_intestine_physiology1.15684592
82MP0005646_abnormal_pituitary_gland1.15432086
83MP0010352_gastrointestinal_tract_polyps1.13561372
84MP0003191_abnormal_cellular_cholesterol1.10705128
85MP0002837_dystrophic_cardiac_calcinosis1.09135401
86MP0002019_abnormal_tumor_incidence1.07591982
87MP0006276_abnormal_autonomic_nervous1.07291045
88MP0000703_abnormal_thymus_morphology1.06001268
89MP0010386_abnormal_urinary_bladder1.04106487
90MP0003303_peritoneal_inflammation1.04008945
91MP0002405_respiratory_system_inflammati1.03981044
92MP0003252_abnormal_bile_duct1.03769793
93MP0001188_hyperpigmentation1.02164955
94MP0005499_abnormal_olfactory_system1.01337660
95MP0005394_taste/olfaction_phenotype1.01337660
96MP0003011_delayed_dark_adaptation1.00020297
97MP0000371_diluted_coat_color0.97378173
98MP0003866_abnormal_defecation0.97037000
99MP0008872_abnormal_physiological_respon0.96963314
100MP0000598_abnormal_liver_morphology0.96029091
101MP0002272_abnormal_nervous_system0.95066898
102MP0001905_abnormal_dopamine_level0.94749619
103MP0001666_abnormal_nutrient_absorption0.94032013
104MP0003718_maternal_effect0.93311159
105MP0003724_increased_susceptibility_to0.93256305
106MP0002933_joint_inflammation0.92824072
107MP0000372_irregular_coat_pigmentation0.91858455
108MP0001968_abnormal_touch/_nociception0.91636962
109MP0003567_abnormal_fetal_cardiomyocyte0.91426345
110MP0008932_abnormal_embryonic_tissue0.91423493
111MP0000858_altered_metastatic_potential0.91285335
112MP0002876_abnormal_thyroid_physiology0.90936514
113MP0000313_abnormal_cell_death0.89544965
114MP0002736_abnormal_nociception_after0.88101848
115MP0002163_abnormal_gland_morphology0.87728067
116MP0005379_endocrine/exocrine_gland_phen0.87160826
117MP0001929_abnormal_gametogenesis0.86371230
118MP0000609_abnormal_liver_physiology0.86248913
119MP0003122_maternal_imprinting0.85910027
120MP0000350_abnormal_cell_proliferation0.85240119
121MP0005319_abnormal_enzyme/_coenzyme0.85036592
122MP0009763_increased_sensitivity_to0.84144951
123MP0003868_abnormal_feces_composition0.84049820
124MP0001873_stomach_inflammation0.82967268
125MP0003943_abnormal_hepatobiliary_system0.82712720
126MP0005408_hypopigmentation0.81891928
127MP0005332_abnormal_amino_acid0.81874197
128MP0004215_abnormal_myocardial_fiber0.80832687
129MP0010329_abnormal_lipoprotein_level0.80690271
130MP0002160_abnormal_reproductive_system0.80612297
131MP0009764_decreased_sensitivity_to0.78433109
132MP0004147_increased_porphyrin_level0.77228655
133MP0004742_abnormal_vestibular_system0.76800183
134MP0001486_abnormal_startle_reflex0.76254178
135MP0003221_abnormal_cardiomyocyte_apopto0.75968871
136MP0002638_abnormal_pupillary_reflex0.75326158
137MP0003121_genomic_imprinting0.75212295
138MP0006036_abnormal_mitochondrial_physio0.75095665
139MP0002095_abnormal_skin_pigmentation0.74835197
140MP0008877_abnormal_DNA_methylation0.72748452
141MP0009765_abnormal_xenobiotic_induced0.71407174
142MP0001119_abnormal_female_reproductive0.67784709
143MP0010307_abnormal_tumor_latency0.67076065
144MP0000477_abnormal_intestine_morphology0.66049502
145MP0003195_calcinosis0.66042109
146MP0002075_abnormal_coat/hair_pigmentati0.65649338

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)3.59750769
2Elevated erythrocyte sedimentation rate (HP:0003565)3.47226277
3Methylmalonic acidemia (HP:0002912)3.34811628
4Aplastic anemia (HP:0001915)3.27743957
5IgM deficiency (HP:0002850)3.13737545
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.10037975
7Thrombocytosis (HP:0001894)3.06851723
8Acute necrotizing encephalopathy (HP:0006965)3.05425790
9Stomach cancer (HP:0012126)3.05065003
10Hypobetalipoproteinemia (HP:0003563)2.97686901
11Mitochondrial inheritance (HP:0001427)2.93892821
12Myositis (HP:0100614)2.92754488
13Abnormality of pyrimidine metabolism (HP:0004353)2.92345417
14Panhypogammaglobulinemia (HP:0003139)2.82375104
15Reticulocytopenia (HP:0001896)2.82134533
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81431762
17Increased CSF lactate (HP:0002490)2.75726337
18Birth length less than 3rd percentile (HP:0003561)2.75452430
19Progressive macrocephaly (HP:0004481)2.74458747
20Pancreatic cysts (HP:0001737)2.74181945
21Abnormality of B cell number (HP:0010975)2.74116896
22Methylmalonic aciduria (HP:0012120)2.73782100
23Abnormal mitochondria in muscle tissue (HP:0008316)2.73440559
24Hepatocellular necrosis (HP:0001404)2.71470547
25Abolished electroretinogram (ERG) (HP:0000550)2.68358208
26Acute encephalopathy (HP:0006846)2.65124895
27Abnormal number of erythroid precursors (HP:0012131)2.63992759
28Type I transferrin isoform profile (HP:0003642)2.60611404
29Recurrent abscess formation (HP:0002722)2.57598582
30Recurrent bacterial skin infections (HP:0005406)2.57333313
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.56470254
32Medial flaring of the eyebrow (HP:0010747)2.54763011
33Colon cancer (HP:0003003)2.54443138
34Abnormality of cells of the erythroid lineage (HP:0012130)2.51939492
35Prolonged partial thromboplastin time (HP:0003645)2.49602042
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48951445
37Molar tooth sign on MRI (HP:0002419)2.45310554
38Abnormality of midbrain morphology (HP:0002418)2.45310554
39Stomatitis (HP:0010280)2.42899436
40True hermaphroditism (HP:0010459)2.41530502
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.41280138
42Pancreatic fibrosis (HP:0100732)2.37280427
43Hyperglycinemia (HP:0002154)2.36468162
44Increased hepatocellular lipid droplets (HP:0006565)2.36151042
45Lactic acidosis (HP:0003128)2.35832148
46Abnormality of T cell number (HP:0011839)2.35661878
47Increased serum lactate (HP:0002151)2.34971492
48Retrobulbar optic neuritis (HP:0100654)2.33707965
49Optic neuritis (HP:0100653)2.33707965
50Absent thumb (HP:0009777)2.33103081
51Petechiae (HP:0000967)2.33078980
52Orchitis (HP:0100796)2.31978349
53Oral leukoplakia (HP:0002745)2.31834016
54Vacuolated lymphocytes (HP:0001922)2.31689793
55Hypothermia (HP:0002045)2.31255192
56Congenital stationary night blindness (HP:0007642)2.28888902
57Abnormality of the renal cortex (HP:0011035)2.23561544
58Abnormality of the anterior horn cell (HP:0006802)2.22386258
59Degeneration of anterior horn cells (HP:0002398)2.22386258
60Chronic diarrhea (HP:0002028)2.19460922
61IgG deficiency (HP:0004315)2.19428852
623-Methylglutaconic aciduria (HP:0003535)2.18841453
63Intrahepatic cholestasis (HP:0001406)2.18552974
64Keratoconjunctivitis sicca (HP:0001097)2.18380556
65Abnormality of eosinophils (HP:0001879)2.15723572
66Amyotrophic lateral sclerosis (HP:0007354)2.15034239
67Prolonged bleeding time (HP:0003010)2.15013865
68Hyperbilirubinemia (HP:0002904)2.14735392
6911 pairs of ribs (HP:0000878)2.14497651
70Microretrognathia (HP:0000308)2.12564766
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12391507
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12391507
73Steatorrhea (HP:0002570)2.11991503
74Abnormality of fatty-acid metabolism (HP:0004359)2.11400273
75Hypoplasia of the thymus (HP:0000778)2.11356943
76Renal cortical cysts (HP:0000803)2.10670763
77Encephalitis (HP:0002383)2.10374335
78Bile duct proliferation (HP:0001408)2.10340160
79Abnormal biliary tract physiology (HP:0012439)2.10340160
80Hypoproteinemia (HP:0003075)2.09763510
81Chromsome breakage (HP:0040012)2.09748212
82Fat malabsorption (HP:0002630)2.09117409
83Lipid accumulation in hepatocytes (HP:0006561)2.08685078
84T lymphocytopenia (HP:0005403)2.08435567
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07112265
86Pancytopenia (HP:0001876)2.05997853
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05953095
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05827112
89Abnormality of alanine metabolism (HP:0010916)2.05827112
90Hyperalaninemia (HP:0003348)2.05827112
91Thyroiditis (HP:0100646)2.05316864
92Lymphoma (HP:0002665)2.04813591
93Abnormality of T cell physiology (HP:0011840)2.04656491
94Recurrent cutaneous fungal infections (HP:0011370)2.04341906
95Chronic mucocutaneous candidiasis (HP:0002728)2.04341906
96Agnosia (HP:0010524)2.04246138
97Recurrent gram-negative bacterial infections (HP:0005420)2.04002391
98Severe combined immunodeficiency (HP:0004430)2.03587202
99Keratoconjunctivitis (HP:0001096)2.02039114
100Epistaxis (HP:0000421)2.01909850
101Cerebral edema (HP:0002181)2.01683388
102Abnormality of vitamin B metabolism (HP:0004340)2.00509849
103Abnormality of the vitamin B12 metabolism (HP:0004341)2.00076133
104Broad alveolar ridges (HP:0000187)1.99333537
105Myelodysplasia (HP:0002863)1.98349205
106Combined immunodeficiency (HP:0005387)1.98252991
107Abnormal protein glycosylation (HP:0012346)1.97692053
108Abnormal glycosylation (HP:0012345)1.97692053
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97692053
110Abnormal protein N-linked glycosylation (HP:0012347)1.97692053
111Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96742061
112Recurrent skin infections (HP:0001581)1.95532088
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.94710395
114Abnormality of the intrinsic pathway (HP:0010989)1.94596594
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94295212
116Abnormality of methionine metabolism (HP:0010901)1.94232671
117Abnormality of T cells (HP:0002843)1.94122951
118Aplasia/hypoplasia of the uterus (HP:0008684)1.93474508
119Optic disc pallor (HP:0000543)1.93057381
120B lymphocytopenia (HP:0010976)1.92932779
121Glossoptosis (HP:0000162)1.90699564
122Abnormality of the prostate (HP:0008775)1.90259280
123Nephronophthisis (HP:0000090)1.89375430
124Congenital primary aphakia (HP:0007707)1.88499431
125Impaired platelet aggregation (HP:0003540)1.87906311
126Abnormal platelet function (HP:0011869)1.87906311
127Recurrent viral infections (HP:0004429)1.87227436
128Delayed CNS myelination (HP:0002188)1.87156108
129Conjugated hyperbilirubinemia (HP:0002908)1.86917848
130Eosinophilia (HP:0001880)1.86615976
131Type 2 muscle fiber atrophy (HP:0003554)1.86589547
132Opisthotonus (HP:0002179)1.86553813
133Abnormality of chromosome stability (HP:0003220)1.86400869
134Abnormal rod and cone electroretinograms (HP:0008323)1.85994919
135Bone marrow hypocellularity (HP:0005528)1.85768552
136Dicarboxylic aciduria (HP:0003215)1.85507343
137Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85507343
138Abnormality of serum amino acid levels (HP:0003112)1.84920665
139Anorexia (HP:0002039)1.84590451
140Pallor (HP:0000980)1.84465445
141Abnormality of the labia minora (HP:0012880)1.83796541
142Ketoacidosis (HP:0001993)1.83602566
143Respiratory failure (HP:0002878)1.83544248
144Arterial thrombosis (HP:0004420)1.83205254
145Axonal loss (HP:0003447)1.83186564
146Lethargy (HP:0001254)1.82512335
147Sparse eyelashes (HP:0000653)1.82067127
148Joint hemorrhage (HP:0005261)1.81160249
149Nephrogenic diabetes insipidus (HP:0009806)1.79209303
150Agammaglobulinemia (HP:0004432)1.78155754
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78014737
152Gingival bleeding (HP:0000225)1.77933829
153Attenuation of retinal blood vessels (HP:0007843)1.77369753
154Large for gestational age (HP:0001520)1.77321748
155Ketosis (HP:0001946)1.76891751
156Progressive inability to walk (HP:0002505)1.76887010
157Amaurosis fugax (HP:0100576)1.76747901
158Neutropenia (HP:0001875)1.76711074
159Abnormality of serine family amino acid metabolism (HP:0010894)1.76584085
160Abnormality of glycine metabolism (HP:0010895)1.76584085
161Vasculitis (HP:0002633)1.76192740
162CNS demyelination (HP:0007305)1.75744458
163Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75565498
164Short tibia (HP:0005736)1.75434650
165Ankle contracture (HP:0006466)1.74822002
166Poikiloderma (HP:0001029)1.74363472
167Increased intramyocellular lipid droplets (HP:0012240)1.73923952
168Exertional dyspnea (HP:0002875)1.73363997
169Lymphopenia (HP:0001888)1.71867453
170Generalized aminoaciduria (HP:0002909)1.71227608
171Hyperlipoproteinemia (HP:0010980)1.71180047
172Gait imbalance (HP:0002141)1.70967229
173Microvesicular hepatic steatosis (HP:0001414)1.69466002
174Autoimmune hemolytic anemia (HP:0001890)1.69433354
175Prostate neoplasm (HP:0100787)1.68632390
176Eczematoid dermatitis (HP:0000976)1.68435729
177Hepatic necrosis (HP:0002605)1.68296198
178Hyperammonemia (HP:0001987)1.67857474
179Recurrent bronchitis (HP:0002837)1.66406658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK23.92793358
2ACVR1B3.80510466
3STK162.70158550
4WEE12.66632307
5MAP4K22.59914636
6TRIM282.57854373
7PIK3CG2.47178052
8EIF2AK12.34513148
9BRSK22.24309966
10TXK2.23704531
11ERBB32.19571679
12KIT2.16120332
13EIF2AK32.12561249
14CDC72.10676617
15BUB12.04193329
16MAP4K12.00602893
17WNK31.98977190
18FLT31.92415428
19NUAK11.88997784
20NME21.72756461
21IKBKE1.72357781
22SRPK11.70597589
23NEK91.68193322
24VRK11.68051848
25RPS6KA41.65259228
26BCKDK1.62238487
27STK241.61300176
28TGFBR11.60563353
29GRK11.59516982
30SIK31.57893131
31DYRK31.55988662
32IRAK41.50205456
33TYK21.48626339
34JAK31.47687779
35MAP3K121.45553820
36MAP3K41.43553851
37TEC1.42739720
38PASK1.42130891
39BTK1.41565952
40MAP3K141.39162125
41BMPR21.38458551
42STK38L1.33089784
43PINK11.31110267
44PLK41.30456548
45ZAP701.28440436
46ZAK1.26012170
47PLK21.22384396
48BLK1.21746882
49CAMKK21.21643189
50CSF1R1.20997174
51CSNK1A1L1.20410149
52TBK11.17678540
53ATR1.15916744
54CSNK1G11.14975988
55CSNK1G21.13939674
56ADRBK21.12881552
57IKBKB1.12478218
58FRK1.08476611
59CCNB11.08226898
60PIM21.07949742
61BRSK11.05888318
62MAP2K71.03966255
63FES1.02693321
64MYLK0.97849171
65VRK20.96596152
66MAP3K50.95715168
67PBK0.95163469
68PLK10.94462047
69PLK30.92537407
70CDK190.92470061
71AURKB0.90600497
72FGFR40.90444885
73PIM10.89959352
74SYK0.89315474
75TSSK60.88411310
76CDK80.87599115
77PDK20.86726323
78BMPR1B0.85068826
79LYN0.84596513
80KDR0.84049824
81MKNK10.83270385
82PRKCQ0.81841286
83TNIK0.77849595
84YES10.75723175
85CDK70.74588261
86MAPK130.74082148
87TLK10.73787256
88NEK10.71688438
89EIF2AK20.71097291
90STK100.70569954
91TAOK10.68916952
92INSRR0.68659785
93GRK60.67751032
94MAPK110.67490493
95ITK0.65129938
96SCYL20.64679449
97RPS6KB20.64523110
98CLK10.63314923
99NEK20.63271233
100NLK0.62918529
101PRKCE0.61588855
102FGFR30.61412932
103TGFBR20.60284656
104STK40.60008688
105DYRK1A0.59608619
106CSNK2A10.59206095
107LCK0.58504534
108TESK20.57345196
109MAP3K110.56824053
110GRK70.55437185
111DYRK20.54845780
112TAOK20.53466544
113TNK20.51684708
114RPS6KA60.51407143
115CSNK1G30.51091758
116GRK50.50991356
117CHUK0.49121282
118MAP3K100.48771055
119CHEK20.47670423
120EPHA30.47592861
121IGF1R0.47086990
122TESK10.47072525
123RPS6KA50.46900934
124MAP2K30.46668151
125ERN10.46333383
126CDK40.46276231
127OXSR10.45686512
128BCR0.45650238
129OBSCN0.44274132
130ABL10.44119091
131MAP2K60.44041569
132DAPK20.43690472
133TTK0.43174000
134TAOK30.43146873
135PAK30.42965142
136DAPK10.41687620
137CSNK2A20.40713835
138MST40.39752763
139TIE10.39203905
140MAP3K80.39195995
141MAP3K30.35753523
142LIMK10.34113478
143BRD40.31851708

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80337276
2Proteasome_Homo sapiens_hsa030503.18228987
3Mismatch repair_Homo sapiens_hsa034302.98168531
4Oxidative phosphorylation_Homo sapiens_hsa001902.69096183
5Ribosome_Homo sapiens_hsa030102.45700424
6Base excision repair_Homo sapiens_hsa034102.43712893
7RNA polymerase_Homo sapiens_hsa030202.36570421
8Pyrimidine metabolism_Homo sapiens_hsa002402.28174876
9Parkinsons disease_Homo sapiens_hsa050122.27736622
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24296644
11Asthma_Homo sapiens_hsa053102.20366147
12Type I diabetes mellitus_Homo sapiens_hsa049402.18724261
13Autoimmune thyroid disease_Homo sapiens_hsa053202.14188132
14Nucleotide excision repair_Homo sapiens_hsa034202.14122252
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.97857882
16Homologous recombination_Homo sapiens_hsa034401.94329603
17Spliceosome_Homo sapiens_hsa030401.91105514
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.89812441
19One carbon pool by folate_Homo sapiens_hsa006701.81658809
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77735615
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.70042243
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68804172
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63199112
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63042222
25Butanoate metabolism_Homo sapiens_hsa006501.59271190
26Non-homologous end-joining_Homo sapiens_hsa034501.58820070
27Fatty acid elongation_Homo sapiens_hsa000621.57621204
28Protein export_Homo sapiens_hsa030601.55944503
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55097718
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47342402
31Primary immunodeficiency_Homo sapiens_hsa053401.45367291
32Regulation of autophagy_Homo sapiens_hsa041401.45367197
33RNA transport_Homo sapiens_hsa030131.44117077
34Cell cycle_Homo sapiens_hsa041101.43582136
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42082453
36Folate biosynthesis_Homo sapiens_hsa007901.40311999
37Huntingtons disease_Homo sapiens_hsa050161.38056070
38Selenocompound metabolism_Homo sapiens_hsa004501.35108644
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34879662
40Basal transcription factors_Homo sapiens_hsa030221.33969871
41Peroxisome_Homo sapiens_hsa041461.30699059
42Rheumatoid arthritis_Homo sapiens_hsa053231.26184923
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25435273
44Alzheimers disease_Homo sapiens_hsa050101.22874613
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14238017
46Antigen processing and presentation_Homo sapiens_hsa046121.14198344
47Caffeine metabolism_Homo sapiens_hsa002321.13873044
48Purine metabolism_Homo sapiens_hsa002301.13372315
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13062258
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12088832
51Phototransduction_Homo sapiens_hsa047441.11320582
52Legionellosis_Homo sapiens_hsa051341.09730384
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08709472
54RNA degradation_Homo sapiens_hsa030181.08343438
55Fanconi anemia pathway_Homo sapiens_hsa034601.07590054
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06327919
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05932675
58Nitrogen metabolism_Homo sapiens_hsa009101.05700437
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02616766
60Herpes simplex infection_Homo sapiens_hsa051681.02404545
61Chemical carcinogenesis_Homo sapiens_hsa052041.00268607
62Glutathione metabolism_Homo sapiens_hsa004800.99926556
63Linoleic acid metabolism_Homo sapiens_hsa005910.99329973
64Measles_Homo sapiens_hsa051620.97965269
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.97757602
66Staphylococcus aureus infection_Homo sapiens_hsa051500.96499771
67Pentose phosphate pathway_Homo sapiens_hsa000300.93407057
68p53 signaling pathway_Homo sapiens_hsa041150.92003136
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.91592244
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90920861
71Complement and coagulation cascades_Homo sapiens_hsa046100.89271117
72Retinol metabolism_Homo sapiens_hsa008300.87385236
73Viral myocarditis_Homo sapiens_hsa054160.86481151
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85804054
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.84931619
76Tryptophan metabolism_Homo sapiens_hsa003800.84735250
77Epstein-Barr virus infection_Homo sapiens_hsa051690.84567441
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.83482729
79Systemic lupus erythematosus_Homo sapiens_hsa053220.82382058
80Collecting duct acid secretion_Homo sapiens_hsa049660.78610062
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76916455
82Histidine metabolism_Homo sapiens_hsa003400.76489461
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75255548
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.74841276
85Biosynthesis of amino acids_Homo sapiens_hsa012300.74727050
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73440519
87Fatty acid degradation_Homo sapiens_hsa000710.72344111
88Ether lipid metabolism_Homo sapiens_hsa005650.71642937
89beta-Alanine metabolism_Homo sapiens_hsa004100.69984887
90Leishmaniasis_Homo sapiens_hsa051400.69333526
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68613906
92Fatty acid metabolism_Homo sapiens_hsa012120.67999328
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66957995
94Other glycan degradation_Homo sapiens_hsa005110.65855665
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65802779
96Allograft rejection_Homo sapiens_hsa053300.65415013
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63565640
98Sulfur relay system_Homo sapiens_hsa041220.62397485
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62295089
100Taste transduction_Homo sapiens_hsa047420.62247096
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60634252
102Carbon metabolism_Homo sapiens_hsa012000.58941128
103N-Glycan biosynthesis_Homo sapiens_hsa005100.58825396
104Viral carcinogenesis_Homo sapiens_hsa052030.57515157
105Influenza A_Homo sapiens_hsa051640.54223235
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.54217982
107Starch and sucrose metabolism_Homo sapiens_hsa005000.54057153
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53342424
109Galactose metabolism_Homo sapiens_hsa000520.51874844
110Hematopoietic cell lineage_Homo sapiens_hsa046400.50050905
111Cardiac muscle contraction_Homo sapiens_hsa042600.48785159
112Metabolic pathways_Homo sapiens_hsa011000.48338498
113Arachidonic acid metabolism_Homo sapiens_hsa005900.47988599
114Vitamin digestion and absorption_Homo sapiens_hsa049770.47863649
115Graft-versus-host disease_Homo sapiens_hsa053320.47798434
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47617512
117mRNA surveillance pathway_Homo sapiens_hsa030150.47282318
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44733575
119Hepatitis B_Homo sapiens_hsa051610.44453882
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44305282
121Tyrosine metabolism_Homo sapiens_hsa003500.44191686
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44145119
123Apoptosis_Homo sapiens_hsa042100.42949418
124Propanoate metabolism_Homo sapiens_hsa006400.42874012
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41788122
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41665893
127B cell receptor signaling pathway_Homo sapiens_hsa046620.41561156
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40810246
129Olfactory transduction_Homo sapiens_hsa047400.39660002
130Glycerolipid metabolism_Homo sapiens_hsa005610.39658519
131Pyruvate metabolism_Homo sapiens_hsa006200.38580266
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38529883
133Sulfur metabolism_Homo sapiens_hsa009200.37496441
134Steroid biosynthesis_Homo sapiens_hsa001000.37474512
135Pertussis_Homo sapiens_hsa051330.35134897

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