ORC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.99882879
2kynurenine metabolic process (GO:0070189)4.01598710
3neural tube formation (GO:0001841)3.88575557
4indole-containing compound catabolic process (GO:0042436)3.81981797
5indolalkylamine catabolic process (GO:0046218)3.81981797
6tryptophan catabolic process (GO:0006569)3.81981797
7CENP-A containing nucleosome assembly (GO:0034080)3.77577934
8gamma-aminobutyric acid transport (GO:0015812)3.70643150
9negative regulation of translation, ncRNA-mediated (GO:0040033)3.66946064
10regulation of translation, ncRNA-mediated (GO:0045974)3.66946064
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.66946064
12indolalkylamine metabolic process (GO:0006586)3.62501449
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57974853
14DNA double-strand break processing (GO:0000729)3.56974342
15kinetochore organization (GO:0051383)3.52931202
16L-fucose catabolic process (GO:0042355)3.52284258
17fucose catabolic process (GO:0019317)3.52284258
18L-fucose metabolic process (GO:0042354)3.52284258
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51521131
20regulation of mitotic spindle checkpoint (GO:1903504)3.51521131
21chromatin remodeling at centromere (GO:0031055)3.46853494
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45430329
23proteasome assembly (GO:0043248)3.40926228
24kinetochore assembly (GO:0051382)3.40812324
25rRNA modification (GO:0000154)3.32894722
26negative regulation of mitotic sister chromatid separation (GO:2000816)3.26100066
27negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26100066
28negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26100066
29negative regulation of sister chromatid segregation (GO:0033046)3.26100066
30pyrimidine nucleobase catabolic process (GO:0006208)3.25446119
317-methylguanosine RNA capping (GO:0009452)3.23010593
32RNA capping (GO:0036260)3.23010593
33tryptophan metabolic process (GO:0006568)3.19179548
34negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19117743
35response to pheromone (GO:0019236)3.18968895
36cilium or flagellum-dependent cell motility (GO:0001539)3.18877884
37spindle checkpoint (GO:0031577)3.18781187
387-methylguanosine mRNA capping (GO:0006370)3.17949071
39presynaptic membrane assembly (GO:0097105)3.17687455
40regulation of sister chromatid segregation (GO:0033045)3.16555435
41regulation of mitotic sister chromatid separation (GO:0010965)3.16555435
42regulation of mitotic sister chromatid segregation (GO:0033047)3.16555435
43mitotic spindle assembly checkpoint (GO:0007094)3.16411907
44cullin deneddylation (GO:0010388)3.15081085
45rRNA methylation (GO:0031167)3.14991136
46spindle assembly checkpoint (GO:0071173)3.12396055
47regulation of hippo signaling (GO:0035330)3.11838706
48viral mRNA export from host cell nucleus (GO:0046784)3.09730051
49negative regulation of chromosome segregation (GO:0051985)3.09464708
50protein deneddylation (GO:0000338)3.08063775
51mitotic spindle checkpoint (GO:0071174)3.07977836
52negative regulation of mitosis (GO:0045839)3.07912529
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07728397
54replication fork processing (GO:0031297)3.07238835
55DNA replication-independent nucleosome organization (GO:0034724)3.05469134
56DNA replication-independent nucleosome assembly (GO:0006336)3.05469134
57startle response (GO:0001964)3.03397194
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02750504
59deoxyribose phosphate biosynthetic process (GO:0046385)3.00800331
602-deoxyribonucleotide biosynthetic process (GO:0009265)3.00800331
61epithelial cilium movement (GO:0003351)2.97904877
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.97846788
63termination of RNA polymerase III transcription (GO:0006386)2.97846788
64behavioral response to ethanol (GO:0048149)2.97146268
65regulation of gene silencing by RNA (GO:0060966)2.96733678
66regulation of posttranscriptional gene silencing (GO:0060147)2.96733678
67regulation of gene silencing by miRNA (GO:0060964)2.96733678
68spinal cord motor neuron differentiation (GO:0021522)2.94388695
69vesicle docking involved in exocytosis (GO:0006904)2.94125297
70nonmotile primary cilium assembly (GO:0035058)2.92894065
71mitotic metaphase plate congression (GO:0007080)2.92598850
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92026498
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91802061
74indole-containing compound metabolic process (GO:0042430)2.91120537
75histone exchange (GO:0043486)2.90935143
76membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90385731
77postsynaptic membrane organization (GO:0001941)2.88725752
78cilium morphogenesis (GO:0060271)2.87713678
79kidney morphogenesis (GO:0060993)2.85475535
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84361609
81cilium movement (GO:0003341)2.83543454
82cilium organization (GO:0044782)2.83325416
83presynaptic membrane organization (GO:0097090)2.82112084
84detection of light stimulus involved in sensory perception (GO:0050962)2.81947128
85detection of light stimulus involved in visual perception (GO:0050908)2.81947128
86deoxyribonucleotide biosynthetic process (GO:0009263)2.80403710
87positive regulation of developmental pigmentation (GO:0048087)2.80170466
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80053272
89transcription elongation from RNA polymerase I promoter (GO:0006362)2.79986399
90nucleobase catabolic process (GO:0046113)2.79669233
91regulation of pigment cell differentiation (GO:0050932)2.78769176
92cornea development in camera-type eye (GO:0061303)2.77973956
93cilium assembly (GO:0042384)2.77088907
94neuronal action potential (GO:0019228)2.77055549
95positive regulation of cell cycle checkpoint (GO:1901978)2.76891200
96reflex (GO:0060004)2.76243592
97sulfation (GO:0051923)2.75427468
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74684947
99transmission of nerve impulse (GO:0019226)2.74357630
100cellular ketone body metabolic process (GO:0046950)2.74113595
101pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70569884
102retinal cone cell development (GO:0046549)2.70522816
103vesicle docking (GO:0048278)2.70303996
104establishment of integrated proviral latency (GO:0075713)2.69591706
105protein K11-linked ubiquitination (GO:0070979)2.69084701
106serotonin metabolic process (GO:0042428)2.68765645
107negative regulation of nuclear division (GO:0051784)2.68550551
108attachment of spindle microtubules to kinetochore (GO:0008608)2.68456976
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68378428
110termination of RNA polymerase I transcription (GO:0006363)2.67703534
111peristalsis (GO:0030432)2.67301377
112oxidative demethylation (GO:0070989)2.66020353
113positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.64681311
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.64331641
115photoreceptor cell maintenance (GO:0045494)2.63454757
116neuron cell-cell adhesion (GO:0007158)2.61956701
117nephron tubule morphogenesis (GO:0072078)2.61789490
118nephron epithelium morphogenesis (GO:0072088)2.61789490
119negative regulation of transcription by competitive promoter binding (GO:0010944)2.61324227
120regulation of mesoderm development (GO:2000380)2.61302243
121interkinetic nuclear migration (GO:0022027)2.60595709
122cellular response to sterol (GO:0036315)2.59027381
123atrial cardiac muscle cell action potential (GO:0086014)2.58850311
124positive regulation of mitotic sister chromatid separation (GO:1901970)2.58342199
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58342199
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58342199
127negative regulation of mast cell activation (GO:0033004)2.58159492
128DNA ligation (GO:0006266)2.58099131
129protein localization to cilium (GO:0061512)2.57982351
130metaphase plate congression (GO:0051310)2.57667888
131membrane repolarization during action potential (GO:0086011)2.56987586
132signal peptide processing (GO:0006465)2.56802121
133centriole replication (GO:0007099)2.56045865
134proline transport (GO:0015824)2.55828707
135pyrimidine dimer repair (GO:0006290)2.55314286
136somite development (GO:0061053)2.55300812
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.55188456
138NADH dehydrogenase complex assembly (GO:0010257)2.55188456
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55188456
140primary amino compound metabolic process (GO:1901160)2.55187354
141rRNA catabolic process (GO:0016075)2.54032590
142purine nucleobase biosynthetic process (GO:0009113)2.53610245
143spliceosomal snRNP assembly (GO:0000387)2.52439403
144negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.51331248
145negative regulation of ligase activity (GO:0051352)2.51331248
146regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50090737
147microtubule anchoring (GO:0034453)2.49368064
148DNA damage response, detection of DNA damage (GO:0042769)2.49248958
149ketone body metabolic process (GO:1902224)2.48455037
150protein complex biogenesis (GO:0070271)2.48041752
151axoneme assembly (GO:0035082)2.47700446
152mRNA splice site selection (GO:0006376)2.47524347
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46547189
154regulation of chromosome segregation (GO:0051983)2.46429096
155transcription-coupled nucleotide-excision repair (GO:0006283)2.46420889
156inner ear receptor stereocilium organization (GO:0060122)2.46417962
157protein neddylation (GO:0045116)2.46100150
158NAD biosynthetic process (GO:0009435)2.45090286
159protein localization to synapse (GO:0035418)2.44878054
160glutamate receptor signaling pathway (GO:0007215)2.43664946
161positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.43621402
162negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43460734
163regulation of action potential (GO:0098900)2.42820370
164reciprocal DNA recombination (GO:0035825)2.42527884
165reciprocal meiotic recombination (GO:0007131)2.42527884
166membrane depolarization during action potential (GO:0086010)2.42005899
167spliceosomal complex assembly (GO:0000245)2.41629873
168somite rostral/caudal axis specification (GO:0032525)2.41611507
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41348064
170ribosome assembly (GO:0042255)2.41176469
171maturation of 5.8S rRNA (GO:0000460)2.40975028
172protein polyglutamylation (GO:0018095)2.40928441
173regulation of glucokinase activity (GO:0033131)2.39852542
174regulation of hexokinase activity (GO:1903299)2.39852542
175positive regulation of oligodendrocyte differentiation (GO:0048714)2.39520539
176protein K11-linked deubiquitination (GO:0035871)2.38294606
177embryonic axis specification (GO:0000578)2.38261505
178establishment of protein localization to Golgi (GO:0072600)2.37733265
179cell morphogenesis involved in neuron differentiation (GO:0048667)2.37504708
180limb development (GO:0060173)2.37349831
181appendage development (GO:0048736)2.37349831
182regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.36429554
183deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.36195603
184negative regulation of synaptic transmission, GABAergic (GO:0032229)2.35102780
185negative regulation of cell division (GO:0051782)2.34802211
186positive regulation of ligase activity (GO:0051351)2.33673855
187transcription elongation from RNA polymerase II promoter (GO:0006368)2.33667466
188establishment of chromosome localization (GO:0051303)2.33400722
189nucleotide-excision repair, DNA gap filling (GO:0006297)2.31928910
190protein localization to microtubule cytoskeleton (GO:0072698)2.30549340
191gamma-aminobutyric acid signaling pathway (GO:0007214)2.29989806
192regulation of double-strand break repair via homologous recombination (GO:0010569)2.29957260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.46410869
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85532930
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68851023
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.60912836
5FUS_26573619_Chip-Seq_HEK293_Human2.59987445
6TAF15_26573619_Chip-Seq_HEK293_Human2.54104106
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47236814
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39951831
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28854543
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.24465223
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.23555912
12EWS_26573619_Chip-Seq_HEK293_Human2.18896943
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.13500457
14E2F7_22180533_ChIP-Seq_HELA_Human2.13331141
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10904593
16ELK1_19687146_ChIP-ChIP_HELA_Human2.07770222
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04261088
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02596119
19IGF1R_20145208_ChIP-Seq_DFB_Human1.96912720
20P300_19829295_ChIP-Seq_ESCs_Human1.96625106
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95003711
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91063724
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90686435
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90124212
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86177632
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85034274
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80272473
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.78103542
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73385612
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70980822
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68375223
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61384487
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.60953919
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60648448
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59388994
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58940787
37AR_21572438_ChIP-Seq_LNCaP_Human1.58655012
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57872092
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57253921
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57253921
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57251177
42TCF4_23295773_ChIP-Seq_U87_Human1.55674780
43VDR_23849224_ChIP-Seq_CD4+_Human1.55082114
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54193823
45AR_25329375_ChIP-Seq_VCAP_Human1.54042562
46BCAT_22108803_ChIP-Seq_LS180_Human1.52190835
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50351692
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49384474
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49246221
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.47938113
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46107910
52REST_21632747_ChIP-Seq_MESCs_Mouse1.44294355
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41786493
54CBP_20019798_ChIP-Seq_JUKART_Human1.41786493
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41771103
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41768576
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.40931140
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37984342
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37760370
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37386048
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.36843331
62VDR_22108803_ChIP-Seq_LS180_Human1.36001667
63ER_23166858_ChIP-Seq_MCF-7_Human1.35995441
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35757733
65SMAD4_21799915_ChIP-Seq_A2780_Human1.35272164
66RUNX2_22187159_ChIP-Seq_PCA_Human1.34552478
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.34226917
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33748922
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.32906919
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32621755
71TP53_16413492_ChIP-PET_HCT116_Human1.31311930
72TCF4_22108803_ChIP-Seq_LS180_Human1.31058564
73RNF2_27304074_Chip-Seq_NSC_Mouse1.30535604
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30148402
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25395386
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25377094
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25138955
78P53_22387025_ChIP-Seq_ESCs_Mouse1.24643091
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.23876000
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23588481
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23168234
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.23086478
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22311336
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22305699
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20978992
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.20401099
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20165436
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19725333
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19150237
90EZH2_22144423_ChIP-Seq_EOC_Human1.18909243
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18366753
92JUN_21703547_ChIP-Seq_K562_Human1.17904437
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.17197237
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.16580988
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16545529
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16328759
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.16265604
98SOX9_26525672_Chip-Seq_HEART_Mouse1.16124409
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15839848
100SOX2_19829295_ChIP-Seq_ESCs_Human1.15570922
101NANOG_19829295_ChIP-Seq_ESCs_Human1.15570922
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15506209
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.14795321
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.14377795
105EZH2_27304074_Chip-Seq_ESCs_Mouse1.14116652
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13692371
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13637832
108IRF1_19129219_ChIP-ChIP_H3396_Human1.13574395
109TP53_22573176_ChIP-Seq_HFKS_Human1.12738683
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12684681
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.12376223
112P300_18555785_Chip-Seq_ESCs_Mouse1.11594663
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11463165
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11245968
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.11061941
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10455087
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10377566
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.10119989
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.10051746
120* FOXP3_21729870_ChIP-Seq_TREG_Human1.09829000
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09554835
122ZNF274_21170338_ChIP-Seq_K562_Hela1.09537958
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09537727
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08671632
125KDM2B_26808549_Chip-Seq_REH_Human1.07912738
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.07881050
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.07209774
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06288626
129EED_16625203_ChIP-ChIP_MESCs_Mouse1.05141225
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.04886154
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04241538
132E2F1_21310950_ChIP-Seq_MCF-7_Human1.04035468
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03630104
134THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03382939
135FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03289110
136DCP1A_22483619_ChIP-Seq_HELA_Human1.03268264
137STAT3_23295773_ChIP-Seq_U87_Human1.03202644
138JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02946027
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02697533
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02357970
141AHR_22903824_ChIP-Seq_MCF-7_Human1.02144923
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.01915081
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01744554
144FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00828007
145FOXA1_25329375_ChIP-Seq_VCAP_Human1.00828007
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00357722
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00098119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.69193169
2MP0000569_abnormal_digit_pigmentation3.23678783
3MP0006292_abnormal_olfactory_placode2.89130382
4MP0003787_abnormal_imprinting2.81944324
5MP0005423_abnormal_somatic_nervous2.65245343
6MP0001188_hyperpigmentation2.64598114
7MP0001529_abnormal_vocalization2.50908196
8MP0009697_abnormal_copulation2.50224619
9MP0003123_paternal_imprinting2.50100967
10MP0008877_abnormal_DNA_methylation2.48278972
11MP0003121_genomic_imprinting2.46431845
12MP0003195_calcinosis2.40753708
13MP0008058_abnormal_DNA_repair2.30645921
14MP0003878_abnormal_ear_physiology2.18647734
15MP0005377_hearing/vestibular/ear_phenot2.18647734
16MP0005171_absent_coat_pigmentation2.12592726
17MP0004859_abnormal_synaptic_plasticity2.12493828
18MP0003646_muscle_fatigue2.08776806
19MP0000015_abnormal_ear_pigmentation2.03447945
20MP0010094_abnormal_chromosome_stability1.99456623
21MP0001905_abnormal_dopamine_level1.98645288
22MP0001968_abnormal_touch/_nociception1.92634840
23MP0001984_abnormal_olfaction1.90647095
24MP0003111_abnormal_nucleus_morphology1.90528801
25MP0004957_abnormal_blastocyst_morpholog1.89823530
26MP0002736_abnormal_nociception_after1.87165451
27MP0009046_muscle_twitch1.85642153
28MP0004043_abnormal_pH_regulation1.85367794
29MP0000427_abnormal_hair_cycle1.84853454
30MP0003635_abnormal_synaptic_transmissio1.79964963
31MP0008057_abnormal_DNA_replication1.79227160
32MP0003693_abnormal_embryo_hatching1.79050628
33MP0003077_abnormal_cell_cycle1.75311513
34MP0005646_abnormal_pituitary_gland1.71313284
35MP0009745_abnormal_behavioral_response1.69659043
36MP0005253_abnormal_eye_physiology1.62858750
37MP0004133_heterotaxia1.62127804
38MP0002653_abnormal_ependyma_morphology1.61877291
39MP0001501_abnormal_sleep_pattern1.61022326
40MP0002638_abnormal_pupillary_reflex1.59418612
41MP0000566_synostosis1.58783604
42MP0002572_abnormal_emotion/affect_behav1.57771873
43MP0002063_abnormal_learning/memory/cond1.56994193
44MP0002102_abnormal_ear_morphology1.56107496
45MP0008007_abnormal_cellular_replicative1.54231063
46MP0003315_abnormal_perineum_morphology1.52960948
47MP0002067_abnormal_sensory_capabilities1.51424599
48MP0006276_abnormal_autonomic_nervous1.50011727
49MP0000383_abnormal_hair_follicle1.43154585
50MP0004885_abnormal_endolymph1.42550029
51MP0003718_maternal_effect1.42466442
52MP0002272_abnormal_nervous_system1.41506412
53MP0003137_abnormal_impulse_conducting1.40497997
54MP0004147_increased_porphyrin_level1.38405005
55MP0002064_seizures1.36896136
56MP0002837_dystrophic_cardiac_calcinosis1.34900342
57MP0001486_abnormal_startle_reflex1.33912797
58MP0000778_abnormal_nervous_system1.33604629
59MP0005386_behavior/neurological_phenoty1.33275301
60MP0004924_abnormal_behavior1.33275301
61MP0003122_maternal_imprinting1.33153745
62MP0004742_abnormal_vestibular_system1.33013025
63MP0008872_abnormal_physiological_respon1.31501436
64MP0002163_abnormal_gland_morphology1.30920474
65MP0003950_abnormal_plasma_membrane1.30269707
66MP0005645_abnormal_hypothalamus_physiol1.29190210
67MP0003119_abnormal_digestive_system1.27567872
68MP0002928_abnormal_bile_duct1.26752029
69MP0002735_abnormal_chemical_nociception1.25819254
70MP0004145_abnormal_muscle_electrophysio1.23230056
71MP0002184_abnormal_innervation1.22304090
72MP0005187_abnormal_penis_morphology1.18846830
73MP0002734_abnormal_mechanical_nocicepti1.18151545
74MP0001485_abnormal_pinna_reflex1.17614262
75MP0010386_abnormal_urinary_bladder1.17432598
76MP0001970_abnormal_pain_threshold1.17032360
77MP0003786_premature_aging1.16297475
78MP0002733_abnormal_thermal_nociception1.16182472
79MP0002095_abnormal_skin_pigmentation1.15800752
80MP0000631_abnormal_neuroendocrine_gland1.14998739
81MP0004270_analgesia1.11486228
82MP0008932_abnormal_embryonic_tissue1.11449178
83MP0008961_abnormal_basal_metabolism1.11121488
84MP0002234_abnormal_pharynx_morphology1.09832780
85MP0003879_abnormal_hair_cell1.07943925
86MP0005174_abnormal_tail_pigmentation1.05201331
87MP0004142_abnormal_muscle_tone1.04431834
88MP0005195_abnormal_posterior_eye1.01246087
89MP0001293_anophthalmia0.99591244
90MP0003890_abnormal_embryonic-extraembry0.98014109
91MP0000647_abnormal_sebaceous_gland0.95857661
92MP0003011_delayed_dark_adaptation0.93131662
93MP0009780_abnormal_chondrocyte_physiolo0.92349017
94MP0001440_abnormal_grooming_behavior0.91817418
95MP0000026_abnormal_inner_ear0.91713857
96MP0003937_abnormal_limbs/digits/tail_de0.91619331
97MP0002229_neurodegeneration0.91124362
98MP0001963_abnormal_hearing_physiology0.90594225
99MP0002009_preneoplasia0.90449444
100MP0002557_abnormal_social/conspecific_i0.89578585
101MP0008789_abnormal_olfactory_epithelium0.89150060
102MP0003283_abnormal_digestive_organ0.88659505
103MP0000537_abnormal_urethra_morphology0.87475127
104MP0005499_abnormal_olfactory_system0.87466739
105MP0005394_taste/olfaction_phenotype0.87466739
106MP0001661_extended_life_span0.87416679
107MP0005379_endocrine/exocrine_gland_phen0.84123178
108MP0001324_abnormal_eye_pigmentation0.83767585
109MP0004134_abnormal_chest_morphology0.83302012
110MP0002822_catalepsy0.82899586
111MP0008875_abnormal_xenobiotic_pharmacok0.81910211
112MP0002876_abnormal_thyroid_physiology0.80795530
113MP0005551_abnormal_eye_electrophysiolog0.80742647
114MP0002751_abnormal_autonomic_nervous0.79770501
115MP0002396_abnormal_hematopoietic_system0.79614846
116MP0005391_vision/eye_phenotype0.79442013
117MP0003755_abnormal_palate_morphology0.79122097
118MP0003567_abnormal_fetal_cardiomyocyte0.78763025
119MP0002210_abnormal_sex_determination0.78538012
120MP0000516_abnormal_urinary_system0.78032789
121MP0005367_renal/urinary_system_phenotyp0.78032789
122MP0000538_abnormal_urinary_bladder0.77359517
123MP0003698_abnormal_male_reproductive0.76955680
124MP0005389_reproductive_system_phenotype0.75032076
125MP0003136_yellow_coat_color0.73962618
126MP0004085_abnormal_heartbeat0.73833873
127MP0000681_abnormal_thyroid_gland0.72052146
128MP0002938_white_spotting0.72001218
129MP0003943_abnormal_hepatobiliary_system0.70375161
130MP0008569_lethality_at_weaning0.69733964
131MP0002152_abnormal_brain_morphology0.69729297
132MP0002882_abnormal_neuron_morphology0.69378887
133MP0002160_abnormal_reproductive_system0.69089570
134MP0001177_atelectasis0.68117474
135MP0002752_abnormal_somatic_nervous0.67921312
136MP0009379_abnormal_foot_pigmentation0.67615139
137MP0004215_abnormal_myocardial_fiber0.67379890
138MP0001986_abnormal_taste_sensitivity0.67051610
139MP0006072_abnormal_retinal_apoptosis0.66908106
140MP0001919_abnormal_reproductive_system0.66187010
141MP0000955_abnormal_spinal_cord0.66151438

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.90259021
2Focal motor seizures (HP:0011153)3.85657171
3Genetic anticipation (HP:0003743)3.75510235
4Nephronophthisis (HP:0000090)3.58157173
5Abnormality of the renal medulla (HP:0100957)3.16703415
6* Birth length less than 3rd percentile (HP:0003561)3.11003518
7Abnormality of the renal cortex (HP:0011035)3.02854043
8Inability to walk (HP:0002540)3.01394807
9Prostate neoplasm (HP:0100787)2.88833025
10Congenital stationary night blindness (HP:0007642)2.87191374
11Abnormality of the labia minora (HP:0012880)2.85509130
12Progressive inability to walk (HP:0002505)2.85470347
13Hyperventilation (HP:0002883)2.83648158
14Fair hair (HP:0002286)2.77948048
15Cystic liver disease (HP:0006706)2.73514386
16Abnormality of incisor morphology (HP:0011063)2.67982887
17Absent/shortened dynein arms (HP:0200106)2.63564098
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.63564098
19Type II lissencephaly (HP:0007260)2.62801839
20Attenuation of retinal blood vessels (HP:0007843)2.55486308
21Epileptic encephalopathy (HP:0200134)2.54648066
22Clumsiness (HP:0002312)2.53445465
23Protruding tongue (HP:0010808)2.51993618
24Lissencephaly (HP:0001339)2.50657990
25Tubular atrophy (HP:0000092)2.50052352
26Supernumerary spleens (HP:0009799)2.47915418
27Chronic hepatic failure (HP:0100626)2.46405140
28Genital tract atresia (HP:0001827)2.46272488
29Abnormality of the nasal septum (HP:0000419)2.45742803
30Patent foramen ovale (HP:0001655)2.44343356
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43196550
32Pancreatic fibrosis (HP:0100732)2.41115905
33Meckel diverticulum (HP:0002245)2.38804960
34Vaginal atresia (HP:0000148)2.38513403
35Sclerocornea (HP:0000647)2.37054271
36Furrowed tongue (HP:0000221)2.36238530
37Medial flaring of the eyebrow (HP:0010747)2.33847422
38Chromsome breakage (HP:0040012)2.33690871
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.33326325
40Large for gestational age (HP:0001520)2.30854372
41Abnormality of the preputium (HP:0100587)2.30436895
42Abnormal ciliary motility (HP:0012262)2.29845464
43Papillary thyroid carcinoma (HP:0002895)2.29576491
44Generalized hypopigmentation of hair (HP:0011358)2.29284766
45Febrile seizures (HP:0002373)2.27680151
46Acute necrotizing encephalopathy (HP:0006965)2.27654884
47Drooling (HP:0002307)2.23359707
48Abnormality of the ileum (HP:0001549)2.23046137
49Abolished electroretinogram (ERG) (HP:0000550)2.20834571
50Abnormality of the columella (HP:0009929)2.20288581
51Nephrogenic diabetes insipidus (HP:0009806)2.17980659
52* Patellar aplasia (HP:0006443)2.17324919
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.17316348
54Progressive macrocephaly (HP:0004481)2.15958036
55Abnormal respiratory motile cilium morphology (HP:0005938)2.15637689
56Abnormal respiratory epithelium morphology (HP:0012253)2.15637689
57Congenital hepatic fibrosis (HP:0002612)2.14170244
58Gait imbalance (HP:0002141)2.12154046
59Atonic seizures (HP:0010819)2.11630249
60Cerebellar dysplasia (HP:0007033)2.11198209
61Renal cortical cysts (HP:0000803)2.10896699
62Volvulus (HP:0002580)2.08388881
63Broad-based gait (HP:0002136)2.08110083
64Absent speech (HP:0001344)2.07107655
65Anencephaly (HP:0002323)2.05781642
66Chorioretinal atrophy (HP:0000533)2.05221748
67Congenital primary aphakia (HP:0007707)2.05213906
68Abnormality of chromosome stability (HP:0003220)2.04380611
69Pancreatic cysts (HP:0001737)2.02618930
70Pendular nystagmus (HP:0012043)2.00630648
71Postaxial foot polydactyly (HP:0001830)2.00623148
72Irregular epiphyses (HP:0010582)2.00619272
73Male pseudohermaphroditism (HP:0000037)2.00146208
74Flat capital femoral epiphysis (HP:0003370)1.99141582
75Widely spaced teeth (HP:0000687)1.98980865
76Congenital, generalized hypertrichosis (HP:0004540)1.98719298
77Excessive salivation (HP:0003781)1.98299725
78* Aplasia/Hypoplasia of the patella (HP:0006498)1.97740136
79Urinary bladder sphincter dysfunction (HP:0002839)1.96197869
80Aplasia cutis congenita (HP:0001057)1.95359946
81Neoplasm of the adrenal cortex (HP:0100641)1.95349361
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95341794
83Abnormality of alanine metabolism (HP:0010916)1.95341794
84Hyperalaninemia (HP:0003348)1.95341794
85Decreased circulating renin level (HP:0003351)1.94837997
86Degeneration of the lateral corticospinal tracts (HP:0002314)1.94427495
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94427495
88Preaxial hand polydactyly (HP:0001177)1.93846058
89Submucous cleft hard palate (HP:0000176)1.93444576
90Focal seizures (HP:0007359)1.92965508
91Poor coordination (HP:0002370)1.92343112
92Duodenal stenosis (HP:0100867)1.92066098
93Small intestinal stenosis (HP:0012848)1.92066098
94Abnormality of the right ventricle (HP:0001707)1.91998914
95Small epiphyses (HP:0010585)1.91621575
96Morphological abnormality of the pyramidal tract (HP:0002062)1.91176792
97Abnormality of midbrain morphology (HP:0002418)1.90709562
98Molar tooth sign on MRI (HP:0002419)1.90709562
99Abnormal drinking behavior (HP:0030082)1.89853353
100Polydipsia (HP:0001959)1.89853353
101Gaze-evoked nystagmus (HP:0000640)1.88475614
102Abnormal mitochondria in muscle tissue (HP:0008316)1.86731148
103Nephroblastoma (Wilms tumor) (HP:0002667)1.85670087
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85639803
105Bony spicule pigmentary retinopathy (HP:0007737)1.85631934
106Abnormal respiratory motile cilium physiology (HP:0012261)1.84740752
107Rectovaginal fistula (HP:0000143)1.84312397
108Rectal fistula (HP:0100590)1.84312397
109Small hand (HP:0200055)1.83505598
110Dandy-Walker malformation (HP:0001305)1.82850321
111Premature graying of hair (HP:0002216)1.81657603
112Septate vagina (HP:0001153)1.80816425
113Oligodactyly (hands) (HP:0001180)1.80042281
114Progressive cerebellar ataxia (HP:0002073)1.79210421
115Abnormal biliary tract physiology (HP:0012439)1.78905659
116Bile duct proliferation (HP:0001408)1.78905659
117Hypoplastic ischia (HP:0003175)1.78302461
118Cerebral hypomyelination (HP:0006808)1.78118999
119Prominent supraorbital ridges (HP:0000336)1.78025877
120Abnormality of the incisor (HP:0000676)1.77446708
121Mitochondrial inheritance (HP:0001427)1.77407417
122Colon cancer (HP:0003003)1.76670065
123Aqueductal stenosis (HP:0002410)1.76503817
124Limb dystonia (HP:0002451)1.76308590
125Capillary hemangiomas (HP:0005306)1.76210062
126Thyroiditis (HP:0100646)1.76082261
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.76017248
128Increased hepatocellular lipid droplets (HP:0006565)1.75965745
129Partial agenesis of the corpus callosum (HP:0001338)1.75867377
130Fibular hypoplasia (HP:0003038)1.75822197
131Postaxial hand polydactyly (HP:0001162)1.75817730
132Short foot (HP:0001773)1.74990859
133Embryonal renal neoplasm (HP:0011794)1.74281986
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74026009
135Rough bone trabeculation (HP:0100670)1.73763809
136True hermaphroditism (HP:0010459)1.73035699
137Aganglionic megacolon (HP:0002251)1.72611410
138Preaxial foot polydactyly (HP:0001841)1.71955801
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.71906946
140Abnormality of the pons (HP:0007361)1.71673511
141Scrotal hypoplasia (HP:0000046)1.71371956
142Increased serum pyruvate (HP:0003542)1.71278632
143Abnormality of glycolysis (HP:0004366)1.71278632
144Specific learning disability (HP:0001328)1.70599417
145Astigmatism (HP:0000483)1.70526541
146Short tibia (HP:0005736)1.70413686
1473-Methylglutaconic aciduria (HP:0003535)1.66874823
148Fetal akinesia sequence (HP:0001989)1.66262735
149Abnormal lung lobation (HP:0002101)1.65967689
150Clubbing of toes (HP:0100760)1.65702081
151Optic nerve hypoplasia (HP:0000609)1.64368913
152Absence seizures (HP:0002121)1.64310208
153Long nose (HP:0003189)1.63322448
154Absent forearm bone (HP:0003953)1.62524195
155Aplasia involving forearm bones (HP:0009822)1.62524195
156Absent epiphyses (HP:0010577)1.62140425
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62140425
158Increased CSF lactate (HP:0002490)1.62098525
159Facial hemangioma (HP:0000329)1.61972024
160Type 2 muscle fiber atrophy (HP:0003554)1.61503224
161Dialeptic seizures (HP:0011146)1.61063497
162Sloping forehead (HP:0000340)1.60528019
163Absent radius (HP:0003974)1.59850710
164Bone marrow hypocellularity (HP:0005528)1.58883993
165Autoamputation (HP:0001218)1.58538172
166Unsteady gait (HP:0002317)1.58149693
167* Gastroesophageal reflux (HP:0002020)1.58065177
168Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58033122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.58415424
2CASK3.51884954
3MKNK23.51224050
4MKNK13.36683511
5INSRR3.17470768
6SRPK12.72169948
7BUB12.67434216
8EIF2AK12.51551794
9EIF2AK32.12644322
10TNIK1.95620162
11NTRK31.91168295
12GRK11.87724527
13MAP3K121.84925910
14ACVR1B1.82788256
15MAP2K71.78393431
16WNK41.75060416
17CDK81.70208240
18WEE11.67612541
19STK161.66846135
20PLK31.66618146
21CDC71.63868638
22ZAK1.63014199
23FRK1.61643583
24EPHA41.59387978
25MAP4K21.55569647
26SIK31.53238101
27PLK21.50697788
28VRK11.48530057
29MAP3K41.44976110
30PLK41.43993063
31PINK11.42449586
32NUAK11.42133532
33AKT31.37063135
34YES11.34074063
35TSSK61.32214388
36NEK61.31793840
37CCNB11.28854613
38MST41.28418017
39TAOK21.27770594
40CAMKK21.27043071
41PRPF4B1.24328828
42DAPK21.23735543
43FGFR21.20808692
44TAOK31.15709556
45CDK191.14315934
46STK391.13431175
47MAPK131.11577490
48BCR1.11068209
49MAPK151.08403250
50CAMK1D1.08069413
51ADRBK11.07942801
52ERBB31.07586783
53NME11.05259234
54CDK31.05224836
55CAMK1G1.02327435
56SGK21.01302524
57MUSK1.00969558
58PAK31.00285863
59PBK0.98472643
60EIF2AK20.95980062
61PLK10.93812430
62WNK30.93532675
63NTRK20.93053677
64TRIM280.92186065
65BMPR20.90548945
66ADRBK20.90118181
67OXSR10.85945352
68CSNK1G20.82720063
69DYRK20.81971755
70BRSK20.81897244
71MARK10.80343937
72TLK10.75764396
73PNCK0.73434561
74GRK70.73239195
75ATR0.72979947
76MAPKAPK50.72733799
77NEK10.71944047
78CSNK1G30.70620167
79NEK20.70245458
80AURKB0.68854626
81PKN10.62716338
82TXK0.62028902
83SGK2230.61648479
84SGK4940.61648479
85CSNK1A1L0.61399748
86MINK10.60230461
87MAP2K40.57403385
88CAMK2B0.57186668
89OBSCN0.56877230
90PRKCG0.54832173
91STK30.54548996
92ATM0.54155854
93CHEK20.52091005
94BRSK10.50993604
95STK38L0.50937057
96CSNK1G10.50100406
97DAPK10.49291471
98LIMK10.49074912
99TGFBR10.47420138
100PTK2B0.47316830
101DYRK30.46945563
102STK110.46867643
103TTK0.46593865
104CAMK2A0.46367742
105BRD40.46308340
106CAMKK10.44602009
107CAMK10.44491502
108CAMK40.43886627
109CHEK10.40953777
110DYRK1A0.40865021
111RPS6KA50.39784705
112CDK10.39462662
113PIK3CA0.39255502
114LATS10.38949687
115PRKCE0.37770543
116PRKAA20.37395695
117PRKACA0.35376468
118ERBB20.35277504
119CSNK2A10.34746546
120CSNK1D0.34668319
121NLK0.34280160
122TAF10.34034553
123MELK0.33136479
124PRKAA10.32878016
125PASK0.32867520
126CDK180.32752169
127CHUK0.31907790
128SGK10.31825971
129WNK10.30664880
130CDK50.29881673
131ERBB40.29621871
132RPS6KA60.29134694
133PHKG10.28918632
134PHKG20.28918632
135BLK0.28519486
136AURKA0.28063077
137PRKG10.27823516
138TEC0.27581921
139CDK20.27421885
140CSNK2A20.27247006
141FES0.26331086
142CSNK1A10.26006380
143PRKACB0.25883952
144RPS6KB10.25019970

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.25980155
2RNA polymerase_Homo sapiens_hsa030203.04568858
3Butanoate metabolism_Homo sapiens_hsa006502.90104614
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86244656
5Nicotine addiction_Homo sapiens_hsa050332.70242811
6Mismatch repair_Homo sapiens_hsa034302.56616188
7Basal transcription factors_Homo sapiens_hsa030222.49995807
8Nitrogen metabolism_Homo sapiens_hsa009102.43033542
9Spliceosome_Homo sapiens_hsa030402.30492417
10Linoleic acid metabolism_Homo sapiens_hsa005912.20361703
11Non-homologous end-joining_Homo sapiens_hsa034502.17969406
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15938883
13Nucleotide excision repair_Homo sapiens_hsa034202.13146116
14RNA degradation_Homo sapiens_hsa030182.11534471
15Fanconi anemia pathway_Homo sapiens_hsa034602.09854815
16DNA replication_Homo sapiens_hsa030302.09201296
17* Cell cycle_Homo sapiens_hsa041102.07658658
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04267774
19RNA transport_Homo sapiens_hsa030132.01216319
20Tryptophan metabolism_Homo sapiens_hsa003801.94222688
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.89477447
22Homologous recombination_Homo sapiens_hsa034401.88572774
23Protein export_Homo sapiens_hsa030601.79296335
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72362240
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71742144
26Selenocompound metabolism_Homo sapiens_hsa004501.66733412
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55192100
28Circadian entrainment_Homo sapiens_hsa047131.52485285
29ABC transporters_Homo sapiens_hsa020101.50806614
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47627031
31Pyrimidine metabolism_Homo sapiens_hsa002401.45179794
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42125214
33Propanoate metabolism_Homo sapiens_hsa006401.40565962
34Glutamatergic synapse_Homo sapiens_hsa047241.40282894
35GABAergic synapse_Homo sapiens_hsa047271.36853642
36Amphetamine addiction_Homo sapiens_hsa050311.36428968
37Morphine addiction_Homo sapiens_hsa050321.34804078
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.33660359
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33433798
40Purine metabolism_Homo sapiens_hsa002301.33043940
41Caffeine metabolism_Homo sapiens_hsa002321.31009237
42Serotonergic synapse_Homo sapiens_hsa047261.30765015
43Oxidative phosphorylation_Homo sapiens_hsa001901.29949783
44Oocyte meiosis_Homo sapiens_hsa041141.29255271
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27942143
46Base excision repair_Homo sapiens_hsa034101.22999422
47Long-term potentiation_Homo sapiens_hsa047201.22802555
48Histidine metabolism_Homo sapiens_hsa003401.21537910
49Taste transduction_Homo sapiens_hsa047421.19593437
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.17455631
51mRNA surveillance pathway_Homo sapiens_hsa030151.16259058
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15892030
53Parkinsons disease_Homo sapiens_hsa050121.13838673
54Olfactory transduction_Homo sapiens_hsa047401.11935650
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11084979
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07309135
57Collecting duct acid secretion_Homo sapiens_hsa049661.06931972
58Huntingtons disease_Homo sapiens_hsa050161.05277299
59Phototransduction_Homo sapiens_hsa047441.02292319
60Regulation of autophagy_Homo sapiens_hsa041401.02145698
61Synaptic vesicle cycle_Homo sapiens_hsa047211.00709298
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98794355
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98638093
64Epstein-Barr virus infection_Homo sapiens_hsa051690.98519784
65Dopaminergic synapse_Homo sapiens_hsa047280.98465814
66Chemical carcinogenesis_Homo sapiens_hsa052040.97679928
67beta-Alanine metabolism_Homo sapiens_hsa004100.97320128
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96188747
69Retinol metabolism_Homo sapiens_hsa008300.93857216
70p53 signaling pathway_Homo sapiens_hsa041150.92895243
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91496937
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90283608
73Glycerolipid metabolism_Homo sapiens_hsa005610.88580688
74Long-term depression_Homo sapiens_hsa047300.88138530
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88124948
76Vitamin B6 metabolism_Homo sapiens_hsa007500.85749090
77Alzheimers disease_Homo sapiens_hsa050100.84289624
78Circadian rhythm_Homo sapiens_hsa047100.84076957
79Renin secretion_Homo sapiens_hsa049240.83169794
80Dorso-ventral axis formation_Homo sapiens_hsa043200.82967280
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81607704
82Peroxisome_Homo sapiens_hsa041460.79828218
83Gastric acid secretion_Homo sapiens_hsa049710.78690066
84Oxytocin signaling pathway_Homo sapiens_hsa049210.78637089
85Calcium signaling pathway_Homo sapiens_hsa040200.77868504
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77095706
87Basal cell carcinoma_Homo sapiens_hsa052170.76463344
88Ovarian steroidogenesis_Homo sapiens_hsa049130.75665785
89Axon guidance_Homo sapiens_hsa043600.75131149
90Alcoholism_Homo sapiens_hsa050340.74757130
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73880594
92Hedgehog signaling pathway_Homo sapiens_hsa043400.72075844
93Autoimmune thyroid disease_Homo sapiens_hsa053200.71952618
94Fatty acid biosynthesis_Homo sapiens_hsa000610.71625717
95Allograft rejection_Homo sapiens_hsa053300.70311355
96Systemic lupus erythematosus_Homo sapiens_hsa053220.68214763
97Insulin secretion_Homo sapiens_hsa049110.68114922
98Steroid biosynthesis_Homo sapiens_hsa001000.67022904
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66917579
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66762625
101Type I diabetes mellitus_Homo sapiens_hsa049400.66183190
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65485322
103Rheumatoid arthritis_Homo sapiens_hsa053230.65451530
104Vibrio cholerae infection_Homo sapiens_hsa051100.63344886
105Hippo signaling pathway_Homo sapiens_hsa043900.61242733
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59514561
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58534833
108Arachidonic acid metabolism_Homo sapiens_hsa005900.57816013
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57643003
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57631497
111Salivary secretion_Homo sapiens_hsa049700.57403295
112One carbon pool by folate_Homo sapiens_hsa006700.55861372
113Lysine degradation_Homo sapiens_hsa003100.54891468
114Cholinergic synapse_Homo sapiens_hsa047250.54865696
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53821449
116Cardiac muscle contraction_Homo sapiens_hsa042600.53616111
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.50188701
118TGF-beta signaling pathway_Homo sapiens_hsa043500.50175523
119Viral carcinogenesis_Homo sapiens_hsa052030.48512811
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.45340618
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44343712
122Sphingolipid metabolism_Homo sapiens_hsa006000.43838599
123cAMP signaling pathway_Homo sapiens_hsa040240.43097468
124Primary immunodeficiency_Homo sapiens_hsa053400.43049842
125MAPK signaling pathway_Homo sapiens_hsa040100.42114289
126Herpes simplex infection_Homo sapiens_hsa051680.41431741
127Ras signaling pathway_Homo sapiens_hsa040140.40771849
128GnRH signaling pathway_Homo sapiens_hsa049120.40753641
129HTLV-I infection_Homo sapiens_hsa051660.40623728
130Wnt signaling pathway_Homo sapiens_hsa043100.40552134
131Fat digestion and absorption_Homo sapiens_hsa049750.40096929
132Cocaine addiction_Homo sapiens_hsa050300.39885908
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38539831
134Melanoma_Homo sapiens_hsa052180.38138673
135Vitamin digestion and absorption_Homo sapiens_hsa049770.37028222
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35749017
137Type II diabetes mellitus_Homo sapiens_hsa049300.34818541
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34767981
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34403736
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32423862
141Gap junction_Homo sapiens_hsa045400.32117845
142Metabolic pathways_Homo sapiens_hsa011000.31482413
143Colorectal cancer_Homo sapiens_hsa052100.31331756
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.31074794
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.30147494
146Ether lipid metabolism_Homo sapiens_hsa005650.28411782
147Shigellosis_Homo sapiens_hsa051310.27731590
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26983579
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26771169
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26603180

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