ORC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.02706013
2nuclear pore organization (GO:0006999)5.39025462
3nuclear pore complex assembly (GO:0051292)5.36693165
4DNA replication-dependent nucleosome assembly (GO:0006335)5.18287385
5DNA replication-dependent nucleosome organization (GO:0034723)5.18287385
6protein localization to chromosome, centromeric region (GO:0071459)4.98718237
7DNA replication checkpoint (GO:0000076)4.94334165
8meiotic chromosome segregation (GO:0045132)4.90394254
9regulation of nuclear cell cycle DNA replication (GO:0033262)4.89591335
10mitotic sister chromatid segregation (GO:0000070)4.89153441
11polyketide metabolic process (GO:0030638)4.73071559
12doxorubicin metabolic process (GO:0044598)4.73071559
13daunorubicin metabolic process (GO:0044597)4.73071559
14DNA unwinding involved in DNA replication (GO:0006268)4.61817332
15sister chromatid segregation (GO:0000819)4.46179851
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.24307460
17regulation of telomere maintenance via telomerase (GO:0032210)4.18938901
18regulation of centriole replication (GO:0046599)4.09751498
19mitotic chromosome condensation (GO:0007076)4.09197978
20* DNA replication initiation (GO:0006270)4.08586248
21ribosome biogenesis (GO:0042254)4.03065383
22pore complex assembly (GO:0046931)4.02493759
23mitotic metaphase plate congression (GO:0007080)3.99722635
24mitotic nuclear envelope disassembly (GO:0007077)3.97877803
25formation of translation preinitiation complex (GO:0001731)3.95562812
26negative regulation of cell cycle G2/M phase transition (GO:1902750)3.94729423
27mitotic sister chromatid cohesion (GO:0007064)3.92386756
28rRNA modification (GO:0000154)3.88124135
29heterochromatin organization (GO:0070828)3.87334330
30DNA duplex unwinding (GO:0032508)3.83810506
31DNA geometric change (GO:0032392)3.83112185
32DNA strand elongation involved in DNA replication (GO:0006271)3.80300931
33histone H4-K12 acetylation (GO:0043983)3.79649336
34non-recombinational repair (GO:0000726)3.77884582
35double-strand break repair via nonhomologous end joining (GO:0006303)3.77884582
36rRNA methylation (GO:0031167)3.77487667
37chromatin assembly (GO:0031497)3.74600435
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74024176
39attachment of spindle microtubules to kinetochore (GO:0008608)3.73464028
40membrane disassembly (GO:0030397)3.70133712
41nuclear envelope disassembly (GO:0051081)3.70133712
42regulation of translation in response to stress (GO:0043555)3.64775349
43regulation of centrosome cycle (GO:0046605)3.64353181
44rRNA transcription (GO:0009303)3.63457197
45negative regulation of telomerase activity (GO:0051974)3.61618959
46DNA strand elongation (GO:0022616)3.59726369
47histone H4-K8 acetylation (GO:0043982)3.57765372
48histone H4-K5 acetylation (GO:0043981)3.57765372
49reciprocal meiotic recombination (GO:0007131)3.57047477
50reciprocal DNA recombination (GO:0035825)3.57047477
51regulation of centrosome duplication (GO:0010824)3.56310581
52chromatin remodeling at centromere (GO:0031055)3.53835424
53folic acid-containing compound biosynthetic process (GO:0009396)3.52964562
54replication fork processing (GO:0031297)3.49734332
55CENP-A containing nucleosome assembly (GO:0034080)3.49442126
56metaphase plate congression (GO:0051310)3.48011728
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.46229934
58telomere maintenance via semi-conservative replication (GO:0032201)3.45877780
59IMP biosynthetic process (GO:0006188)3.44971002
60DNA replication-independent nucleosome assembly (GO:0006336)3.42304540
61DNA replication-independent nucleosome organization (GO:0034724)3.42304540
62positive regulation of DNA-dependent DNA replication (GO:2000105)3.41721482
63ncRNA catabolic process (GO:0034661)3.41230317
64chromatin assembly or disassembly (GO:0006333)3.40700654
65pre-miRNA processing (GO:0031054)3.40048416
66nucleobase biosynthetic process (GO:0046112)3.38333716
67mitochondrial RNA metabolic process (GO:0000959)3.37074711
68DNA double-strand break processing (GO:0000729)3.36686039
69regulation of mammary gland epithelial cell proliferation (GO:0033599)3.36206258
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.34812576
71negative regulation of epidermis development (GO:0045683)3.34405826
72regulation of posttranscriptional gene silencing (GO:0060147)3.33329183
73regulation of gene silencing by miRNA (GO:0060964)3.33329183
74regulation of gene silencing by RNA (GO:0060966)3.33329183
75ribonucleoprotein complex biogenesis (GO:0022613)3.31117911
76protein K11-linked deubiquitination (GO:0035871)3.28436427
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.27729832
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27729832
79ribosome assembly (GO:0042255)3.27275893
80protein localization to chromosome (GO:0034502)3.22712438
81mitotic recombination (GO:0006312)3.21103544
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.20562745
83double-strand break repair via homologous recombination (GO:0000724)3.20548073
84purine nucleobase biosynthetic process (GO:0009113)3.19401041
85rRNA catabolic process (GO:0016075)3.19222534
86recombinational repair (GO:0000725)3.18718010
87positive regulation of mitotic sister chromatid separation (GO:1901970)3.18396127
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18396127
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18396127
90maintenance of protein location in nucleus (GO:0051457)3.17965676
91cullin deneddylation (GO:0010388)3.17945989
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17593004
93regulation of mitotic spindle checkpoint (GO:1903504)3.17593004
94regulation of double-strand break repair (GO:2000779)3.17025192
95DNA conformation change (GO:0071103)3.16055404
96protein K6-linked ubiquitination (GO:0085020)3.15261202
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14315735
98pseudouridine synthesis (GO:0001522)3.14202591
99regulation of helicase activity (GO:0051095)3.13645823
100monoubiquitinated protein deubiquitination (GO:0035520)3.13556534
101positive regulation of histone H3-K4 methylation (GO:0051571)3.10708171
102kinetochore organization (GO:0051383)3.10046132
103spindle assembly checkpoint (GO:0071173)3.08843565
104spindle checkpoint (GO:0031577)3.08531394
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08280360
106telomere maintenance via recombination (GO:0000722)3.08069929
107UDP-N-acetylglucosamine metabolic process (GO:0006047)3.06737445
108peptidyl-threonine dephosphorylation (GO:0035970)3.06467646
109IMP metabolic process (GO:0046040)3.06152553
110histone exchange (GO:0043486)3.05573501
111establishment of chromosome localization (GO:0051303)3.03883411
112negative regulation of telomere maintenance (GO:0032205)3.03626283
113negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.01873898
114sister chromatid cohesion (GO:0007062)3.01399954
115regulation of DNA endoreduplication (GO:0032875)3.01224833
116positive regulation of chromosome segregation (GO:0051984)3.00263096
117regulation of chromosome segregation (GO:0051983)3.00121272
118establishment of integrated proviral latency (GO:0075713)2.99676532
119regulation of DNA-dependent DNA replication (GO:0090329)2.99127462
120regulation of spindle organization (GO:0090224)2.97866079
121histone-serine phosphorylation (GO:0035404)2.97282784
122negative regulation of chromosome segregation (GO:0051985)2.96905466
123synapsis (GO:0007129)2.94176632
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93703707
125negative regulation of sister chromatid segregation (GO:0033046)2.93703707
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.93703707
127negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93703707
128chromosome segregation (GO:0007059)2.93122365
129aminoglycoside antibiotic metabolic process (GO:0030647)2.91194800
130mismatch repair (GO:0006298)2.91173702
131protein deneddylation (GO:0000338)2.90089915
132RNA stabilization (GO:0043489)2.89866593
133mRNA stabilization (GO:0048255)2.89866593
134mitotic G2/M transition checkpoint (GO:0044818)2.89417076
135DNA ligation (GO:0006266)2.89095542
136chromosome condensation (GO:0030261)2.87300903
137double-strand break repair (GO:0006302)2.83591171
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.83051310
139isotype switching (GO:0045190)2.83051310
140somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.83051310
141mitotic spindle checkpoint (GO:0071174)2.82031843
142regulation of histone H3-K9 methylation (GO:0051570)2.81812216
143response to X-ray (GO:0010165)2.78867381
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77958469
145regulation of mitotic metaphase/anaphase transition (GO:0030071)2.77958469
146regulation of mitotic sister chromatid segregation (GO:0033047)2.75951158
147regulation of sister chromatid segregation (GO:0033045)2.75951158
148regulation of mitotic sister chromatid separation (GO:0010965)2.75951158
149negative regulation of DNA repair (GO:0045738)2.75682591
150DNA strand renaturation (GO:0000733)2.74027916
151DNA recombination (GO:0006310)2.73820913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.19725041
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.20254104
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.14777152
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.85593668
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.35895062
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.35895062
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.35895062
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19887690
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88523279
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83534652
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80849893
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69175502
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57527051
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39063001
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.35023899
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.32802866
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32214394
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29071042
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28182449
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25625943
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24766449
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.24003459
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22581771
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15006284
25ZNF274_21170338_ChIP-Seq_K562_Hela2.14973520
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10404392
27EWS_26573619_Chip-Seq_HEK293_Human2.09993960
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03795254
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.03044757
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.02475504
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99655838
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98502089
33AR_21909140_ChIP-Seq_LNCAP_Human1.96997339
34FUS_26573619_Chip-Seq_HEK293_Human1.94715647
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.92705269
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91515724
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89172965
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.87945664
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86566733
40XRN2_22483619_ChIP-Seq_HELA_Human1.82336981
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.81430041
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77095272
43VDR_23849224_ChIP-Seq_CD4+_Human1.75568958
44IGF1R_20145208_ChIP-Seq_DFB_Human1.73354120
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69583471
46FOXP3_21729870_ChIP-Seq_TREG_Human1.69281449
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68763691
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67732302
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.67001569
50MYC_18940864_ChIP-ChIP_HL60_Human1.64879255
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.64848062
52VDR_22108803_ChIP-Seq_LS180_Human1.64256642
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62161696
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.58311442
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57839188
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57026286
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56144814
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52741351
59MYC_22102868_ChIP-Seq_BL_Human1.51536416
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50625585
61TTF2_22483619_ChIP-Seq_HELA_Human1.48658154
62GABP_19822575_ChIP-Seq_HepG2_Human1.47058132
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.45160598
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44553238
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40637343
66DCP1A_22483619_ChIP-Seq_HELA_Human1.40302604
67ELK1_19687146_ChIP-ChIP_HELA_Human1.39121461
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38494654
69TAF15_26573619_Chip-Seq_HEK293_Human1.37261276
70KDM5A_27292631_Chip-Seq_BREAST_Human1.37086993
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36190209
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35431796
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34371743
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33528277
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31906141
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29320084
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26706865
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.26574632
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24540492
80CIITA_25753668_ChIP-Seq_RAJI_Human1.23325491
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20257847
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20175366
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20089906
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19783339
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19696635
86ER_23166858_ChIP-Seq_MCF-7_Human1.18900574
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18779918
88P300_19829295_ChIP-Seq_ESCs_Human1.17966009
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16870494
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16721704
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14549016
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13221948
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12399450
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12170848
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11566140
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10939969
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.10461554
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10352182
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.10144734
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08110501
101GBX2_23144817_ChIP-Seq_PC3_Human1.07383119
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06730661
103TFEB_21752829_ChIP-Seq_HELA_Human1.06643679
104IRF1_19129219_ChIP-ChIP_H3396_Human1.06217724
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02426667
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02133184
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.01180733
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00557842
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99885224
110EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99765036
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99427704
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98643793
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98389150
114SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97485856
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97162929
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97067481
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96968592
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.96214303
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96100539
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.95618107
121TCF4_23295773_ChIP-Seq_U87_Human0.95560957
122NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95171250
123POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94269139
124STAT3_23295773_ChIP-Seq_U87_Human0.94113346
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92674202
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92629239
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92568115
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92394190
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92304036
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92252294
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92174236
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91934003
133CBP_20019798_ChIP-Seq_JUKART_Human0.91934003
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91694425
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91400325
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90726071
137NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90667013
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.90530979
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89925506
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89897783
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89260488
142EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89026480
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88440741
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85674886
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.85331941
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84781233
147CDX2_22108803_ChIP-Seq_LS180_Human0.84527234
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81544673
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81138467
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80930791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.55361111
2MP0004957_abnormal_blastocyst_morpholog4.43975240
3MP0010094_abnormal_chromosome_stability4.00264042
4MP0003693_abnormal_embryo_hatching3.94366790
5MP0003111_abnormal_nucleus_morphology3.75977044
6MP0003077_abnormal_cell_cycle3.54140497
7MP0006292_abnormal_olfactory_placode3.06451801
8MP0003890_abnormal_embryonic-extraembry2.70337498
9MP0010352_gastrointestinal_tract_polyps2.62809228
10MP0008058_abnormal_DNA_repair2.55233637
11MP0003123_paternal_imprinting2.51194399
12MP0004264_abnormal_extraembryonic_tissu2.51084064
13MP0008007_abnormal_cellular_replicative2.39623381
14MP0009697_abnormal_copulation2.36740577
15MP0000350_abnormal_cell_proliferation2.28902828
16MP0003121_genomic_imprinting2.27474398
17MP0008932_abnormal_embryonic_tissue2.26240877
18MP0005380_embryogenesis_phenotype2.16922377
19MP0001672_abnormal_embryogenesis/_devel2.16922377
20MP0001730_embryonic_growth_arrest2.08390386
21MP0002396_abnormal_hematopoietic_system2.00560681
22MP0003984_embryonic_growth_retardation1.93187975
23MP0003941_abnormal_skin_development1.91789169
24MP0002088_abnormal_embryonic_growth/wei1.90660524
25MP0005075_abnormal_melanosome_morpholog1.87528604
26MP0005499_abnormal_olfactory_system1.86353136
27MP0005394_taste/olfaction_phenotype1.86353136
28MP0002009_preneoplasia1.80344892
29MP0002085_abnormal_embryonic_tissue1.76438889
30MP0002084_abnormal_developmental_patter1.72140225
31MP0003786_premature_aging1.72044457
32MP0003567_abnormal_fetal_cardiomyocyte1.71727806
33MP0003195_calcinosis1.71455015
34MP0001293_anophthalmia1.70789598
35MP0000569_abnormal_digit_pigmentation1.68337325
36MP0001697_abnormal_embryo_size1.64847492
37MP0002086_abnormal_extraembryonic_tissu1.62534305
38MP0010307_abnormal_tumor_latency1.61797882
39MP0003011_delayed_dark_adaptation1.60175276
40MP0000490_abnormal_crypts_of1.54886833
41MP0002653_abnormal_ependyma_morphology1.54135550
42MP0003315_abnormal_perineum_morphology1.52853584
43MP0002080_prenatal_lethality1.49956514
44MP0008877_abnormal_DNA_methylation1.47854872
45MP0004197_abnormal_fetal_growth/weight/1.45526557
46MP0010030_abnormal_orbit_morphology1.44483229
47MP0000313_abnormal_cell_death1.43516409
48MP0000427_abnormal_hair_cycle1.43073024
49MP0002938_white_spotting1.38607011
50MP0003705_abnormal_hypodermis_morpholog1.38062831
51MP0002254_reproductive_system_inflammat1.32975902
52MP0005257_abnormal_intraocular_pressure1.32401646
53MP0001661_extended_life_span1.26892757
54MP0009672_abnormal_birth_weight1.26071293
55MP0006035_abnormal_mitochondrial_morpho1.22904109
56MP0005085_abnormal_gallbladder_physiolo1.21802700
57MP0001849_ear_inflammation1.21110989
58MP0003938_abnormal_ear_development1.20015657
59MP0003122_maternal_imprinting1.19770994
60MP0002092_abnormal_eye_morphology1.18700316
61MP0002102_abnormal_ear_morphology1.17461781
62MP0005395_other_phenotype1.16660650
63MP0004133_heterotaxia1.16387246
64MP0002877_abnormal_melanocyte_morpholog1.15863386
65MP0003937_abnormal_limbs/digits/tail_de1.13389720
66MP0002019_abnormal_tumor_incidence1.13101468
67MP0008789_abnormal_olfactory_epithelium1.08726823
68MP0000383_abnormal_hair_follicle1.08350215
69MP0002210_abnormal_sex_determination1.07852102
70MP0002332_abnormal_exercise_endurance1.07794117
71MP0003787_abnormal_imprinting1.06038655
72MP0000428_abnormal_craniofacial_morphol1.05722452
73MP0001145_abnormal_male_reproductive1.05581665
74MP0003646_muscle_fatigue1.05493330
75MP0004233_abnormal_muscle_weight1.05385758
76MP0003119_abnormal_digestive_system1.03628594
77MP0010678_abnormal_skin_adnexa1.00433446
78MP0000678_abnormal_parathyroid_gland0.99702825
79MP0000432_abnormal_head_morphology0.97199848
80MP0003718_maternal_effect0.95787376
81MP0001764_abnormal_homeostasis0.95379570
82MP0000631_abnormal_neuroendocrine_gland0.93529367
83MP0002127_abnormal_cardiovascular_syste0.93468989
84MP0002233_abnormal_nose_morphology0.92602070
85MP0002114_abnormal_axial_skeleton0.92091525
86MP0001119_abnormal_female_reproductive0.90734166
87MP0006072_abnormal_retinal_apoptosis0.90565230
88MP0009703_decreased_birth_body0.90064364
89MP0002277_abnormal_respiratory_mucosa0.88828883
90MP0004147_increased_porphyrin_level0.88781320
91MP0001929_abnormal_gametogenesis0.88288725
92MP0003698_abnormal_male_reproductive0.87883016
93MP0000358_abnormal_cell_content/0.87685738
94MP0002932_abnormal_joint_morphology0.87320384
95MP0002234_abnormal_pharynx_morphology0.86675512
96MP0003943_abnormal_hepatobiliary_system0.85884469
97MP0003935_abnormal_craniofacial_develop0.84256638
98MP0003755_abnormal_palate_morphology0.84129578
99MP0000049_abnormal_middle_ear0.83715224
100MP0005551_abnormal_eye_electrophysiolog0.83521988
101MP0003221_abnormal_cardiomyocyte_apopto0.82905822
102MP0005384_cellular_phenotype0.82839516
103MP0005220_abnormal_exocrine_pancreas0.82571072
104MP0005389_reproductive_system_phenotype0.82339242
105MP0005408_hypopigmentation0.82264668
106MP0005646_abnormal_pituitary_gland0.81984668
107MP0005266_abnormal_metabolism0.81835534
108MP0002111_abnormal_tail_morphology0.80148071
109MP0008770_decreased_survivor_rate0.79118117
110MP0004808_abnormal_hematopoietic_stem0.78926102
111MP0001666_abnormal_nutrient_absorption0.77728720
112MP0001286_abnormal_eye_development0.76642477
113MP0000653_abnormal_sex_gland0.76159591
114MP0004043_abnormal_pH_regulation0.75707916
115MP0005253_abnormal_eye_physiology0.75413666
116MP0005647_abnormal_sex_gland0.74831407
117MP0003699_abnormal_female_reproductive0.73280811
118MP0000647_abnormal_sebaceous_gland0.72234563
119MP0000762_abnormal_tongue_morphology0.71927521
120MP0002075_abnormal_coat/hair_pigmentati0.70616964
121MP0002697_abnormal_eye_size0.69699339
122MP0004858_abnormal_nervous_system0.69513030
123MP0000703_abnormal_thymus_morphology0.68965066
124MP0002837_dystrophic_cardiac_calcinosis0.68893063
125MP0001529_abnormal_vocalization0.68647264
126MP0005621_abnormal_cell_physiology0.68399586
127MP0003806_abnormal_nucleotide_metabolis0.68322427
128MP0002160_abnormal_reproductive_system0.68254838
129MP0002925_abnormal_cardiovascular_devel0.68129365
130MP0003861_abnormal_nervous_system0.66815177
131MP0005391_vision/eye_phenotype0.66528301
132MP0005076_abnormal_cell_differentiation0.66116942
133MP0001485_abnormal_pinna_reflex0.65009437
134MP0004215_abnormal_myocardial_fiber0.64472102
135MP0003136_yellow_coat_color0.64253805
136MP0005023_abnormal_wound_healing0.63270967
137MP0002722_abnormal_immune_system0.62540702
138MP0002006_tumorigenesis0.62237713
139MP0000372_irregular_coat_pigmentation0.61893344
140MP0000689_abnormal_spleen_morphology0.61572946
141MP0006054_spinal_hemorrhage0.61482075
142MP0002751_abnormal_autonomic_nervous0.61444780
143MP0005332_abnormal_amino_acid0.61031717
144MP0000858_altered_metastatic_potential0.59858974
145MP0003283_abnormal_digestive_organ0.59272486
146MP0002116_abnormal_craniofacial_bone0.59271203
147MP0009333_abnormal_splenocyte_physiolog0.56992909

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.82170973
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70150554
3Chromsome breakage (HP:0040012)4.51323642
4Hypochromic microcytic anemia (HP:0004840)4.39645390
5Bilateral microphthalmos (HP:0007633)4.33308174
6Rhabdomyosarcoma (HP:0002859)4.09055164
7Multiple enchondromatosis (HP:0005701)3.87728472
8Neoplasm of striated muscle (HP:0009728)3.60515534
9Rib fusion (HP:0000902)3.55360115
10Pancreatic islet-cell hyperplasia (HP:0004510)3.45058733
11Medulloblastoma (HP:0002885)3.42363113
12Meckel diverticulum (HP:0002245)3.40880267
13Abnormality of the astrocytes (HP:0100707)3.38137623
14Astrocytoma (HP:0009592)3.38137623
15Nephroblastoma (Wilms tumor) (HP:0002667)3.37797725
16Abnormal lung lobation (HP:0002101)3.19871742
17Abnormality of the ileum (HP:0001549)3.19652115
18Birth length less than 3rd percentile (HP:0003561)3.15864592
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.15156205
20Embryonal renal neoplasm (HP:0011794)3.12959696
21Supernumerary spleens (HP:0009799)3.10954969
22Impulsivity (HP:0100710)3.04382949
23Abnormality of chromosome stability (HP:0003220)2.99513932
24Small intestinal stenosis (HP:0012848)2.86656186
25Duodenal stenosis (HP:0100867)2.86656186
26Abnormality of the preputium (HP:0100587)2.86608418
27Glioma (HP:0009733)2.83304089
28Abnormality of the lower motor neuron (HP:0002366)2.82456437
29Aplasia/hypoplasia of the humerus (HP:0006507)2.79911392
30Hepatoblastoma (HP:0002884)2.73790353
31Trismus (HP:0000211)2.70427962
32Myelodysplasia (HP:0002863)2.66406326
33Biliary tract neoplasm (HP:0100574)2.66281137
34Short humerus (HP:0005792)2.60205982
35Breast hypoplasia (HP:0003187)2.59601058
36Abnormality of the labia minora (HP:0012880)2.55910697
37Neoplasm of the oral cavity (HP:0100649)2.52050405
38Abnormality of the salivary glands (HP:0010286)2.51420632
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.51325608
40Sloping forehead (HP:0000340)2.51286294
41Selective tooth agenesis (HP:0001592)2.50597650
42Abnormality of the pancreatic islet cells (HP:0006476)2.47962783
43Abnormality of endocrine pancreas physiology (HP:0012093)2.47962783
44Pancreatic cysts (HP:0001737)2.43381838
45Atresia of the external auditory canal (HP:0000413)2.43230816
46Fused cervical vertebrae (HP:0002949)2.42679638
47Volvulus (HP:0002580)2.41487928
48Patellar aplasia (HP:0006443)2.39979062
49Rectal fistula (HP:0100590)2.39926671
50Rectovaginal fistula (HP:0000143)2.39926671
51Abnormality of the duodenum (HP:0002246)2.31060743
52Agnosia (HP:0010524)2.30231390
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.29647455
54Hypoplasia of the fovea (HP:0007750)2.29647455
55Abnormality of alanine metabolism (HP:0010916)2.29119024
56Hyperalaninemia (HP:0003348)2.29119024
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29119024
58Abnormal biliary tract morphology (HP:0012440)2.27408040
59Aplasia/Hypoplasia of the patella (HP:0006498)2.27094584
60Shawl scrotum (HP:0000049)2.26686189
61Absent radius (HP:0003974)2.24338345
62Preauricular skin tag (HP:0000384)2.22925163
63Glossoptosis (HP:0000162)2.22615507
64Neoplasm of the adrenal cortex (HP:0100641)2.20633831
65Chronic hepatic failure (HP:0100626)2.20198435
66Premature ovarian failure (HP:0008209)2.18448620
67Microretrognathia (HP:0000308)2.16902517
68Clubbing of toes (HP:0100760)2.16002056
69Facial cleft (HP:0002006)2.14875428
70Abnormality of chromosome segregation (HP:0002916)2.14586168
71Bile duct proliferation (HP:0001408)2.14478534
72Abnormal biliary tract physiology (HP:0012439)2.14478534
73Colon cancer (HP:0003003)2.13762805
74Bone marrow hypocellularity (HP:0005528)2.13045869
75Increased nuchal translucency (HP:0010880)2.12246609
76Abnormality of the renal cortex (HP:0011035)2.11412633
77Aplastic anemia (HP:0001915)2.11092132
78Intestinal fistula (HP:0100819)2.10634806
79Missing ribs (HP:0000921)2.10525758
80Aplasia involving forearm bones (HP:0009822)2.10428857
81Absent forearm bone (HP:0003953)2.10428857
82Carpal bone hypoplasia (HP:0001498)2.10079616
83Amyotrophic lateral sclerosis (HP:0007354)2.07819288
84Atrophy/Degeneration involving motor neurons (HP:0007373)2.07380912
85Neoplasm of the small intestine (HP:0100833)2.07147108
86Hyperglycinuria (HP:0003108)2.06169540
87Breast carcinoma (HP:0003002)2.04804700
88Abnormality of the anterior horn cell (HP:0006802)2.04744527
89Degeneration of anterior horn cells (HP:0002398)2.04744527
90Skin tags (HP:0010609)2.03910287
91Cafe-au-lait spot (HP:0000957)2.02846398
92Pancreatic fibrosis (HP:0100732)2.01737155
93Neoplasm of the colon (HP:0100273)2.01553187
94Microvesicular hepatic steatosis (HP:0001414)2.01261733
95Bifid tongue (HP:0010297)2.00148348
96Testicular atrophy (HP:0000029)1.98203283
97Abnormality of the pons (HP:0007361)1.98073717
98Acanthocytosis (HP:0001927)1.97504215
99Ovarian neoplasm (HP:0100615)1.97490426
100Tracheoesophageal fistula (HP:0002575)1.95883252
101Hypochromic anemia (HP:0001931)1.95365935
102Renal cortical cysts (HP:0000803)1.95010643
103Cerebral hypomyelination (HP:0006808)1.93041906
104Tongue fasciculations (HP:0001308)1.92086620
105Hypoplasia of the pons (HP:0012110)1.91820699
106Prominent nose (HP:0000448)1.91193109
107Triphalangeal thumb (HP:0001199)1.90953248
108Urethral obstruction (HP:0000796)1.90585010
109Angiofibromas (HP:0010615)1.89545411
110Adenoma sebaceum (HP:0009720)1.89545411
111Ectopic kidney (HP:0000086)1.89437573
112Progressive inability to walk (HP:0002505)1.88654124
113Abnormality of the carotid arteries (HP:0005344)1.88496733
114Pendular nystagmus (HP:0012043)1.88028645
115Clitoromegaly (HP:0000057)1.87476690
116Abnormality of homocysteine metabolism (HP:0010919)1.86995641
117Homocystinuria (HP:0002156)1.86995641
118Abnormality of the phalanges of the hallux (HP:0010057)1.86405103
119Enlarged kidneys (HP:0000105)1.86197716
120Hypobetalipoproteinemia (HP:0003563)1.86089234
121Large earlobe (HP:0009748)1.85788807
122Vaginal fistula (HP:0004320)1.85120996
123Gaze-evoked nystagmus (HP:0000640)1.85028426
124Spinal muscular atrophy (HP:0007269)1.83815862
125Anal stenosis (HP:0002025)1.83481620
126Abnormality of serum amino acid levels (HP:0003112)1.82684608
127Embryonal neoplasm (HP:0002898)1.82497726
128Absent thumb (HP:0009777)1.82171896
129Abnormality of the nasal septum (HP:0000419)1.80556681
130Reticulocytopenia (HP:0001896)1.80300031
131Neoplasm of the adrenal gland (HP:0100631)1.79868880
132Secondary amenorrhea (HP:0000869)1.79431404
133Malignant neoplasm of the central nervous system (HP:0100836)1.79153800
134Abnormality of glycine metabolism (HP:0010895)1.79008031
135Abnormality of serine family amino acid metabolism (HP:0010894)1.79008031
136Hypopigmentation of the fundus (HP:0007894)1.78314430
137Supernumerary ribs (HP:0005815)1.77603820
138Abnormality of methionine metabolism (HP:0010901)1.76742261
139Malignant gastrointestinal tract tumors (HP:0006749)1.76683778
140Gastrointestinal carcinoma (HP:0002672)1.76683778
141Hyperinsulinemic hypoglycemia (HP:0000825)1.76155828
142Type I transferrin isoform profile (HP:0003642)1.75994610
143Progressive muscle weakness (HP:0003323)1.75901273
144Abnormality of the fovea (HP:0000493)1.75106832
145Reduced antithrombin III activity (HP:0001976)1.74843571
146Uterine neoplasm (HP:0010784)1.74564937
147Horseshoe kidney (HP:0000085)1.70371118
148Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69998930
149Fair hair (HP:0002286)1.69835294
150Gonadotropin excess (HP:0000837)1.69472190
151Cupped ear (HP:0000378)1.69240560
152Hyperglycinemia (HP:0002154)1.64473827
153Hypoglycemic coma (HP:0001325)1.64062793
154Dandy-Walker malformation (HP:0001305)1.63813362
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.63513767
156Neoplasm of the rectum (HP:0100743)1.61916613
157Preaxial hand polydactyly (HP:0001177)1.59675555
158Small hand (HP:0200055)1.59627689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.74575483
2CDC74.05612090
3FRK3.97782281
4TTK3.58770585
5BUB13.53607331
6WEE13.30700757
7NUAK12.40257550
8GRK52.39341949
9NEK22.39188257
10SRPK12.21023733
11PLK12.19984256
12GRK62.19156616
13CDK72.17192631
14STK102.16501497
15MST42.05801833
16TAF11.99258051
17CHEK21.95019115
18CSF1R1.87532278
19EIF2AK11.80916067
20NEK11.78158989
21EPHA21.71729706
22RPS6KB21.65065889
23FGFR21.55313608
24AURKB1.55180680
25ACVR1B1.54122621
26PBK1.54018953
27BCR1.52596336
28CHEK11.52097622
29BRSK21.49390672
30PLK41.47903738
31ATR1.43710268
32MAP4K21.39727573
33TYRO31.37535422
34PAK41.35887931
35WNK31.33986654
36MKNK11.30738477
37BMPR1B1.30346604
38TGFBR21.30286239
39GRK11.29029844
40VRK11.26864553
41PLK31.26367716
42TRIM281.25862244
43EIF2AK31.24330943
44ERN11.23402287
45DYRK31.23128680
46AURKA1.22343127
47ADRBK21.20308139
48TLK11.18921883
49NLK1.17808242
50MKNK21.17562610
51ALK1.16361533
52CDK41.16109375
53EEF2K1.15787140
54MATK1.12489747
55MOS1.10506843
56FGFR11.07332119
57ATM1.07318316
58TSSK61.07153899
59CAMK1D1.03883973
60CAMK1G1.01763237
61SCYL21.00040631
62MAPK70.97851740
63MAP3K80.97732992
64* CDK20.97727546
65PASK0.96388857
66STK390.96211444
67CSNK1G10.92045308
68TNIK0.90902306
69TESK20.90674962
70CSNK1A1L0.89537392
71BRSK10.89323611
72ERBB30.89016562
73INSRR0.85053054
74MAP3K40.84407241
75LATS10.83522266
76GRK70.81158674
77ZAK0.80688358
78EIF2AK20.79463976
79RPS6KA40.78438280
80MELK0.78184835
81STK40.74726446
82STK30.73397313
83CDK10.73009541
84PNCK0.72324176
85BRD40.71173069
86AKT30.70553238
87MAP3K100.67012991
88CDK80.67012046
89CSNK1G20.65585157
90WNK40.64041074
91NME20.63881409
92STK240.63617420
93AKT20.63543419
94PRKG20.63144451
95PAK10.62530656
96CSNK1G30.61814659
97OXSR10.61262816
98MAPKAPK30.59507448
99VRK20.59301627
100WNK10.58887470
101PLK20.57352322
102LATS20.56304788
103CSNK1E0.55119660
104CAMKK20.54578163
105FLT30.53869527
106MAP3K90.52595702
107MTOR0.51052169
108CSNK2A20.50194510
109PIM10.50095703
110CCNB10.48343869
111PRKAA20.47734139
112PRKCI0.47654306
113NME10.45639838
114RPS6KB10.45514107
115CLK10.45504624
116STK38L0.45396730
117CDK60.44318371
118CDK90.44026860
119PIK3CA0.43925213
120TGFBR10.43868867
121CSNK2A10.40914857
122MAPKAPK50.39273595
123MAPK140.38902184
124CDK30.37785114
125HIPK20.37724707
126NEK60.37634528
127TEC0.37223500
128PDK20.36788362
129FGFR30.36773085
130FER0.36521570
131ADRBK10.36019936
132CAMK40.34801898
133STK160.32907932
134CSNK1D0.30248351
135GSK3B0.29959411
136PRKDC0.29459876
137PDK30.26028934
138PDK40.26028934
139MARK20.25635962
140MAPK100.25042577
141MAPK10.24679492
142DYRK20.22094087
143RPS6KA50.19811155
144AKT10.19328772

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.62882216
2DNA replication_Homo sapiens_hsa030304.54825081
3Mismatch repair_Homo sapiens_hsa034304.10032399
4RNA transport_Homo sapiens_hsa030133.37052294
5Spliceosome_Homo sapiens_hsa030402.99914992
6Homologous recombination_Homo sapiens_hsa034402.81917390
7* Cell cycle_Homo sapiens_hsa041102.80740605
8RNA polymerase_Homo sapiens_hsa030202.75992564
9Vitamin B6 metabolism_Homo sapiens_hsa007502.75056764
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69104815
11Fanconi anemia pathway_Homo sapiens_hsa034602.68701081
12One carbon pool by folate_Homo sapiens_hsa006702.60210508
13Nucleotide excision repair_Homo sapiens_hsa034202.53894458
14Base excision repair_Homo sapiens_hsa034102.51796759
15Propanoate metabolism_Homo sapiens_hsa006402.49347613
16Ribosome_Homo sapiens_hsa030102.34094998
17Non-homologous end-joining_Homo sapiens_hsa034502.20772830
18mRNA surveillance pathway_Homo sapiens_hsa030152.16140003
19RNA degradation_Homo sapiens_hsa030182.06190362
20Pyrimidine metabolism_Homo sapiens_hsa002401.96695060
21Basal transcription factors_Homo sapiens_hsa030221.96477412
22Proteasome_Homo sapiens_hsa030501.88463262
23p53 signaling pathway_Homo sapiens_hsa041151.75157319
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72336950
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59152997
26Lysine degradation_Homo sapiens_hsa003101.49586874
27Protein export_Homo sapiens_hsa030601.47697744
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40251349
29Steroid biosynthesis_Homo sapiens_hsa001001.39528928
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39441798
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35815210
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34511018
33Pyruvate metabolism_Homo sapiens_hsa006201.30475074
34Systemic lupus erythematosus_Homo sapiens_hsa053221.25185152
35Regulation of autophagy_Homo sapiens_hsa041401.25151568
36Fructose and mannose metabolism_Homo sapiens_hsa000511.18843352
37Thyroid cancer_Homo sapiens_hsa052161.18776529
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.16064653
39Caffeine metabolism_Homo sapiens_hsa002321.07406121
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03326190
41Purine metabolism_Homo sapiens_hsa002301.03203141
42Butanoate metabolism_Homo sapiens_hsa006501.03183393
43Viral carcinogenesis_Homo sapiens_hsa052031.01863777
44Oocyte meiosis_Homo sapiens_hsa041141.00345686
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99938872
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99066817
47Nitrogen metabolism_Homo sapiens_hsa009100.96919526
48Herpes simplex infection_Homo sapiens_hsa051680.95851636
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94977732
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94925160
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93049199
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93021761
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91936140
54MicroRNAs in cancer_Homo sapiens_hsa052060.91650659
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90538929
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90479923
57Arachidonic acid metabolism_Homo sapiens_hsa005900.90269331
58Fatty acid metabolism_Homo sapiens_hsa012120.87072502
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86694029
60Epstein-Barr virus infection_Homo sapiens_hsa051690.86094185
61Fatty acid biosynthesis_Homo sapiens_hsa000610.85308705
62mTOR signaling pathway_Homo sapiens_hsa041500.80502688
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75573878
64Tryptophan metabolism_Homo sapiens_hsa003800.74534483
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74281557
66Fatty acid degradation_Homo sapiens_hsa000710.73565214
67Galactose metabolism_Homo sapiens_hsa000520.73459275
68HTLV-I infection_Homo sapiens_hsa051660.72515062
69Linoleic acid metabolism_Homo sapiens_hsa005910.71183525
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70790191
71Phototransduction_Homo sapiens_hsa047440.70030359
72Vitamin digestion and absorption_Homo sapiens_hsa049770.68780027
73Small cell lung cancer_Homo sapiens_hsa052220.65393070
74Folate biosynthesis_Homo sapiens_hsa007900.63904016
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63794239
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63658277
77Fat digestion and absorption_Homo sapiens_hsa049750.61806033
78Circadian rhythm_Homo sapiens_hsa047100.60496045
79Antigen processing and presentation_Homo sapiens_hsa046120.60363204
80Basal cell carcinoma_Homo sapiens_hsa052170.59986125
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59849678
82Hippo signaling pathway_Homo sapiens_hsa043900.59634558
83Arginine biosynthesis_Homo sapiens_hsa002200.58769652
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58607044
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57554499
86Pentose phosphate pathway_Homo sapiens_hsa000300.54856933
87Alcoholism_Homo sapiens_hsa050340.53685502
88N-Glycan biosynthesis_Homo sapiens_hsa005100.53415792
89Colorectal cancer_Homo sapiens_hsa052100.52019107
90TGF-beta signaling pathway_Homo sapiens_hsa043500.51145918
91Apoptosis_Homo sapiens_hsa042100.51052253
92Selenocompound metabolism_Homo sapiens_hsa004500.50511900
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.50203884
94Metabolic pathways_Homo sapiens_hsa011000.50179826
95Retinol metabolism_Homo sapiens_hsa008300.50127538
96Pathways in cancer_Homo sapiens_hsa052000.49723802
97Biosynthesis of amino acids_Homo sapiens_hsa012300.44441826
98Arginine and proline metabolism_Homo sapiens_hsa003300.44156595
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43689784
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.43324414
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42783970
102Hedgehog signaling pathway_Homo sapiens_hsa043400.42758733
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41946475
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41341383
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.41145668
106Sulfur relay system_Homo sapiens_hsa041220.40736132
107Peroxisome_Homo sapiens_hsa041460.39776096
108ABC transporters_Homo sapiens_hsa020100.38559923
109Bladder cancer_Homo sapiens_hsa052190.36491738
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36167281
111Non-small cell lung cancer_Homo sapiens_hsa052230.35275442
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34543702
113Acute myeloid leukemia_Homo sapiens_hsa052210.33320611
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.32622392
115Taste transduction_Homo sapiens_hsa047420.32179127
116Glucagon signaling pathway_Homo sapiens_hsa049220.31534042
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31383606
118Legionellosis_Homo sapiens_hsa051340.31173184
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29593988
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.29592372
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28517061
122Inositol phosphate metabolism_Homo sapiens_hsa005620.27666194
123Other glycan degradation_Homo sapiens_hsa005110.27613708
124Adherens junction_Homo sapiens_hsa045200.27279264
125Wnt signaling pathway_Homo sapiens_hsa043100.27060494
126FoxO signaling pathway_Homo sapiens_hsa040680.27012928
127Starch and sucrose metabolism_Homo sapiens_hsa005000.25359619
128Tight junction_Homo sapiens_hsa045300.24970016
129Notch signaling pathway_Homo sapiens_hsa043300.24471800
130Hepatitis B_Homo sapiens_hsa051610.22965417
131Pancreatic cancer_Homo sapiens_hsa052120.22221488
132Sulfur metabolism_Homo sapiens_hsa009200.22097127
133Prostate cancer_Homo sapiens_hsa052150.21594783
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21464174
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21399073
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20878682
137beta-Alanine metabolism_Homo sapiens_hsa004100.20509110
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20219958
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20129830
140Influenza A_Homo sapiens_hsa051640.19557237
141Proteoglycans in cancer_Homo sapiens_hsa052050.19218988
142Primary immunodeficiency_Homo sapiens_hsa053400.18523584
143Chronic myeloid leukemia_Homo sapiens_hsa052200.17316808
144Ether lipid metabolism_Homo sapiens_hsa005650.16630658
145Melanoma_Homo sapiens_hsa052180.14813360
146HIF-1 signaling pathway_Homo sapiens_hsa040660.12606929
147Hematopoietic cell lineage_Homo sapiens_hsa046400.11295692
148Carbon metabolism_Homo sapiens_hsa012000.10531924
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.09341698
150Endometrial cancer_Homo sapiens_hsa052130.09323121
151Measles_Homo sapiens_hsa051620.08883033
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.08536818
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.07935259

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