ORAI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.95645873
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.95645873
3positive regulation of gamma-delta T cell activation (GO:0046645)5.04974305
4negative T cell selection (GO:0043383)3.89410732
5negative thymic T cell selection (GO:0045060)3.86879779
6behavioral response to nicotine (GO:0035095)3.80907343
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80299745
8regulation of B cell receptor signaling pathway (GO:0050855)3.75335592
9locomotory exploration behavior (GO:0035641)3.51732428
10positive regulation of defense response to virus by host (GO:0002230)3.50365126
11regulation of gamma-delta T cell activation (GO:0046643)3.49832198
12regulation of gamma-delta T cell differentiation (GO:0045586)3.47506432
13positive thymic T cell selection (GO:0045059)3.45261410
14positive T cell selection (GO:0043368)3.43455508
15cellular response to exogenous dsRNA (GO:0071360)3.42637387
16B cell receptor signaling pathway (GO:0050853)3.40484798
17synaptic vesicle maturation (GO:0016188)3.39543835
18T cell selection (GO:0045058)3.34711558
19leukocyte aggregation (GO:0070486)3.27399039
20defense response to protozoan (GO:0042832)3.26701497
21T cell migration (GO:0072678)3.24456728
22thymic T cell selection (GO:0045061)3.23631094
23negative regulation of interleukin-6 production (GO:0032715)3.22134552
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21975981
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20389056
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.20389056
27modulation by symbiont of host immune response (GO:0052553)3.20389056
28positive regulation by symbiont of host defense response (GO:0052509)3.20389056
29modulation by symbiont of host defense response (GO:0052031)3.20389056
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20389056
31response to protozoan (GO:0001562)3.16003734
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15665691
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15665691
34NIK/NF-kappaB signaling (GO:0038061)3.14541288
35mast cell activation (GO:0045576)3.11657622
36regulation of MHC class I biosynthetic process (GO:0045343)3.10801944
37signal complex assembly (GO:0007172)3.08970726
38regulation of mast cell activation (GO:0033003)3.08553047
39purinergic nucleotide receptor signaling pathway (GO:0035590)3.08536878
40regulation of interleukin-12 biosynthetic process (GO:0045075)3.08041448
41negative regulation of interleukin-1 production (GO:0032692)3.07280930
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04361425
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.01306701
44response to interleukin-15 (GO:0070672)3.01256682
45antigen processing and presentation of endogenous antigen (GO:0019883)3.00944808
46mast cell activation involved in immune response (GO:0002279)3.00640117
47mast cell degranulation (GO:0043303)3.00640117
48macrophage activation involved in immune response (GO:0002281)2.99865738
49regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98793642
50regulation of ARF protein signal transduction (GO:0032012)2.98198770
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94705154
52cellular response to interleukin-15 (GO:0071350)2.93992458
53regulation of interferon-beta biosynthetic process (GO:0045357)2.93815467
54response to muramyl dipeptide (GO:0032495)2.93365080
55DNA deamination (GO:0045006)2.93172445
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92491818
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92078050
58interferon-gamma-mediated signaling pathway (GO:0060333)2.90773238
59positive regulation of mast cell activation (GO:0033005)2.89966250
60regulation of glutamate receptor signaling pathway (GO:1900449)2.88830044
61regulation of antigen processing and presentation (GO:0002577)2.88669765
62positive regulation of CREB transcription factor activity (GO:0032793)2.87983476
63myeloid cell activation involved in immune response (GO:0002275)2.87122461
64regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.82985175
65mature B cell differentiation (GO:0002335)2.81514129
66fucose catabolic process (GO:0019317)2.78481747
67L-fucose metabolic process (GO:0042354)2.78481747
68L-fucose catabolic process (GO:0042355)2.78481747
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78124997
70antigen receptor-mediated signaling pathway (GO:0050851)2.74475270
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.73716530
72synaptic vesicle docking involved in exocytosis (GO:0016081)2.72740830
73response to peptidoglycan (GO:0032494)2.71802227
74T cell receptor signaling pathway (GO:0050852)2.71636577
75sodium ion export (GO:0071436)2.71338482
76leukocyte cell-cell adhesion (GO:0007159)2.70731945
77CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.70475037
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70298358
79regulation of interleukin-6 biosynthetic process (GO:0045408)2.68947501
80modulation by symbiont of host cellular process (GO:0044068)2.68947432
81positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67749260
82positive regulation of antigen processing and presentation (GO:0002579)2.67692043
83tryptophan catabolic process (GO:0006569)2.66462628
84indole-containing compound catabolic process (GO:0042436)2.66462628
85indolalkylamine catabolic process (GO:0046218)2.66462628
86negative regulation of interleukin-1 beta production (GO:0032691)2.66320878
87superoxide anion generation (GO:0042554)2.65925758
88regulation of T cell mediated cytotoxicity (GO:0001914)2.65534492
89synaptic vesicle exocytosis (GO:0016079)2.64633973
90negative regulation of T-helper cell differentiation (GO:0045623)2.64431534
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64431534
92regulation of B cell differentiation (GO:0045577)2.63580001
93negative regulation of mast cell activation (GO:0033004)2.62200355
94germinal center formation (GO:0002467)2.61772733
95interferon-gamma production (GO:0032609)2.61122694
96regulation of mast cell degranulation (GO:0043304)2.60673273
97neutrophil activation involved in immune response (GO:0002283)2.59687114
98exploration behavior (GO:0035640)2.59409358
99activated T cell proliferation (GO:0050798)2.58668536
100detection of other organism (GO:0098543)2.57595319
101regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56160217
102regulation of mast cell activation involved in immune response (GO:0033006)2.55696372
103positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.55226209
104microglial cell activation (GO:0001774)2.55002084
105cellular response to interferon-beta (GO:0035458)2.54634040
106positive regulation of granulocyte differentiation (GO:0030854)2.54039687
107negative regulation of lymphocyte mediated immunity (GO:0002707)2.53656335
108positive regulation of protein homooligomerization (GO:0032464)2.53132287
109detection of bacterium (GO:0016045)2.53125057
110purinergic receptor signaling pathway (GO:0035587)2.52434140
111negative regulation of calcium ion transport into cytosol (GO:0010523)2.52104097
112negative regulation of interleukin-12 production (GO:0032695)2.51423461
113regulation of defense response to virus by host (GO:0050691)2.51310954
114negative regulation of leukocyte mediated immunity (GO:0002704)2.50973360
115B cell homeostasis (GO:0001782)2.49896418
116positive regulation of B cell differentiation (GO:0045579)2.49587399
117regulation of Rap GTPase activity (GO:0032317)2.49083767
118regulation of synapse structural plasticity (GO:0051823)2.48945727
119pyrimidine ribonucleoside catabolic process (GO:0046133)2.48632708
120positive regulation of Rap GTPase activity (GO:0032854)2.48490226
121tolerance induction (GO:0002507)2.48183165
122positive regulation of histone deacetylation (GO:0031065)2.47352759
123regulation of interferon-alpha production (GO:0032647)2.47203405
124regulation of isotype switching to IgG isotypes (GO:0048302)2.47193892
125negative regulation of alpha-beta T cell activation (GO:0046636)2.46369364
126autophagic vacuole fusion (GO:0000046)2.46284261
127regulation of ARF GTPase activity (GO:0032312)2.46044466
128kynurenine metabolic process (GO:0070189)2.45874143
129negative regulation of T cell mediated immunity (GO:0002710)2.45264266
130immunoglobulin mediated immune response (GO:0016064)2.45200699
131regulation of MHC class II biosynthetic process (GO:0045346)2.44626859
132leukocyte degranulation (GO:0043299)2.44443253
133positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42506312
134positive regulation of fibroblast migration (GO:0010763)2.42202606
135negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.41757611
136response to host immune response (GO:0052572)2.41719868
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41719868
138regulation of synaptic vesicle exocytosis (GO:2000300)2.41109023
139regulation of neuronal synaptic plasticity (GO:0048168)2.40735109
140immune response-activating cell surface receptor signaling pathway (GO:0002429)2.40625432
141neutrophil activation (GO:0042119)2.40578483
142regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39886834
143vocalization behavior (GO:0071625)2.39694970
144negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39194064
145regulation of T cell receptor signaling pathway (GO:0050856)2.39127982
146response to type I interferon (GO:0034340)2.36587725
147granulocyte activation (GO:0036230)2.36356632
148lymphocyte migration (GO:0072676)2.36328874
149cellular extravasation (GO:0045123)2.34983479
150cellular response to type I interferon (GO:0071357)2.34439682
151type I interferon signaling pathway (GO:0060337)2.34439682
152response to host (GO:0075136)2.33950963
153response to host defenses (GO:0052200)2.33950963
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.33950963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.36562416
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88133243
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.34758190
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.21988207
5EZH2_22144423_ChIP-Seq_EOC_Human2.96786499
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80856577
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.73321669
8RUNX_20019798_ChIP-Seq_JUKART_Human2.60895085
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.58138056
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.57260233
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54276419
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52655457
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.42137604
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39400523
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34086127
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.31486068
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29780674
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24446896
19ZNF274_21170338_ChIP-Seq_K562_Hela2.18479753
20SPI1_23127762_ChIP-Seq_K562_Human2.16268071
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13679420
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09023611
23* MYC_22102868_ChIP-Seq_BL_Human2.08211166
24SCL_19346495_ChIP-Seq_HPC-7_Human2.04170052
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96471815
26* VDR_21846776_ChIP-Seq_THP-1_Human1.96128260
27DROSHA_22980978_ChIP-Seq_HELA_Human1.92166328
28* MYB_26560356_Chip-Seq_TH2_Human1.91483438
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.91400206
30* VDR_24763502_ChIP-Seq_THP-1_Human1.88746560
31KDM2B_26808549_Chip-Seq_DND41_Human1.86751217
32TCF7_22412390_ChIP-Seq_EML_Mouse1.83477876
33* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82575363
34* MAF_26560356_Chip-Seq_TH1_Human1.78738632
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77241427
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76001475
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74994106
38* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72814220
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70709235
40* UTX_26944678_Chip-Seq_JUKART_Human1.65904983
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.65768984
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64742785
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62858795
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61195791
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59994586
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59906868
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56157060
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.53989691
49* MYB_26560356_Chip-Seq_TH1_Human1.50036586
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47142849
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46707453
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.46159986
53* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43744133
54BCL6_27268052_Chip-Seq_Bcells_Human1.43645719
55REST_21632747_ChIP-Seq_MESCs_Mouse1.42645675
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42329062
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40169757
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.38665351
59GATA3_27048872_Chip-Seq_THYMUS_Human1.37577122
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37496297
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36972663
62VDR_24787735_ChIP-Seq_THP-1_Human1.35621948
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.29878834
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29304463
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29111619
66BCOR_27268052_Chip-Seq_Bcells_Human1.27395460
67KDM2B_26808549_Chip-Seq_K562_Human1.26530680
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24715389
69* LXR_22292898_ChIP-Seq_THP-1_Human1.24518601
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24207825
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23230848
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23187250
73SPI1_23547873_ChIP-Seq_NB4_Human1.22069328
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21371760
75ERA_21632823_ChIP-Seq_H3396_Human1.20173740
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19865313
77SMRT_27268052_Chip-Seq_Bcells_Human1.19415769
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18520498
79P300_27268052_Chip-Seq_Bcells_Human1.18017741
80VDR_22108803_ChIP-Seq_LS180_Human1.14792549
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14600290
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13985162
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13533687
84PU_27001747_Chip-Seq_BMDM_Mouse1.12185443
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10573744
86E2F1_20622854_ChIP-Seq_HELA_Human1.10467550
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10382831
88P68_20966046_ChIP-Seq_HELA_Human1.09942231
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.09834084
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09721845
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09007913
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.08489858
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.07988986
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06960409
95MAF_26560356_Chip-Seq_TH2_Human1.06706081
96* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06552950
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06287230
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06287230
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06264009
100* ELK3_25401928_ChIP-Seq_HUVEC_Human1.05275470
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03463361
102OCT4_19829295_ChIP-Seq_ESCs_Human0.99826876
103PHF8_20622854_ChIP-Seq_HELA_Human0.99079886
104* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98866866
105ER_23166858_ChIP-Seq_MCF-7_Human0.97383899
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97332655
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.97132778
108RNF2_27304074_Chip-Seq_ESCs_Mouse0.97047966
109JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96407982
110TAF2_19829295_ChIP-Seq_ESCs_Human0.96067764
111AR_21572438_ChIP-Seq_LNCaP_Human0.95987260
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95639823
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95525421
114STAT1_20625510_ChIP-Seq_HELA_Human0.95164000
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93594122
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92744009
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92286168
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90408979
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90314343
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90314343
121* GATA1_19941826_ChIP-Seq_K562_Human0.90155180
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.89670407
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89136575
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.88953301
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88868314
126GATA3_26560356_Chip-Seq_TH2_Human0.88128899
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87941121
128ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87835047
129GATA1_22025678_ChIP-Seq_K562_Human0.87237494
130OCT4_20526341_ChIP-Seq_ESCs_Human0.87126468
131RXR_22108803_ChIP-Seq_LS180_Human0.86234383
132FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85880506
133* GATA2_19941826_ChIP-Seq_K562_Human0.85815876
134NANOG_20526341_ChIP-Seq_ESCs_Human0.85712863
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85581679
136P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85102675
137RAC3_21632823_ChIP-Seq_H3396_Human0.84553507
138ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84202793
139TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84146633
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83372849
141TP53_22573176_ChIP-Seq_HFKS_Human0.82763284
142GBX2_23144817_ChIP-Seq_PC3_Human0.82642648
143BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.82339692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98162682
2MP0004510_myositis2.98260947
3MP0003303_peritoneal_inflammation2.97625421
4MP0001835_abnormal_antigen_presentation2.88294841
5MP0000685_abnormal_immune_system2.61886650
6MP0000569_abnormal_digit_pigmentation2.55563631
7MP0005000_abnormal_immune_tolerance2.54094588
8MP0003436_decreased_susceptibility_to2.46769066
9MP0005387_immune_system_phenotype2.42723899
10MP0001790_abnormal_immune_system2.42723899
11MP0001800_abnormal_humoral_immune2.41814425
12MP0005671_abnormal_response_to2.39310012
13MP0003635_abnormal_synaptic_transmissio2.35177188
14MP0003880_abnormal_central_pattern2.30793222
15MP0002723_abnormal_immune_serum2.23159288
16MP0002452_abnormal_antigen_presenting2.22156130
17MP0002420_abnormal_adaptive_immunity2.19139347
18MP0003763_abnormal_thymus_physiology2.18533687
19MP0001819_abnormal_immune_cell2.18150697
20MP0002419_abnormal_innate_immunity2.14646026
21MP0009785_altered_susceptibility_to2.09888982
22MP0003172_abnormal_lysosome_physiology2.07525995
23MP0005025_abnormal_response_to2.01665874
24MP0001986_abnormal_taste_sensitivity2.00190522
25MP0002148_abnormal_hypersensitivity_rea1.99559390
26MP0009278_abnormal_bone_marrow1.96779116
27MP0005464_abnormal_platelet_physiology1.95489440
28MP0002398_abnormal_bone_marrow1.87579280
29MP0009745_abnormal_behavioral_response1.86034580
30MP0002063_abnormal_learning/memory/cond1.85672457
31MP0002138_abnormal_hepatobiliary_system1.83426170
32MP0003300_gastrointestinal_ulcer1.79287021
33MP0004947_skin_inflammation1.76459700
34MP0009764_decreased_sensitivity_to1.74173469
35MP0002064_seizures1.71829332
36MP0000716_abnormal_immune_system1.70252875
37MP0002735_abnormal_chemical_nociception1.69358373
38MP0002653_abnormal_ependyma_morphology1.68342868
39MP0003075_altered_response_to1.62366880
40MP0005310_abnormal_salivary_gland1.58706999
41MP0002166_altered_tumor_susceptibility1.56826339
42MP0001968_abnormal_touch/_nociception1.55000449
43MP0002006_tumorigenesis1.53447420
44MP0005174_abnormal_tail_pigmentation1.53419488
45MP0006082_CNS_inflammation1.52414228
46MP0002405_respiratory_system_inflammati1.52230723
47MP0003183_abnormal_peptide_metabolism1.46393377
48MP0004043_abnormal_pH_regulation1.46267551
49MP0001501_abnormal_sleep_pattern1.45661311
50MP0003646_muscle_fatigue1.41824401
51MP0004130_abnormal_muscle_cell1.40927275
52MP0004270_analgesia1.39554581
53MP0000689_abnormal_spleen_morphology1.38825218
54MP0001663_abnormal_digestive_system1.38113816
55MP0001545_abnormal_hematopoietic_system1.34141707
56MP0005397_hematopoietic_system_phenotyp1.34141707
57MP0002572_abnormal_emotion/affect_behav1.33834965
58MP0001873_stomach_inflammation1.33093966
59MP0000703_abnormal_thymus_morphology1.32560832
60MP0001845_abnormal_inflammatory_respons1.32417745
61MP0010155_abnormal_intestine_physiology1.32203810
62MP0002722_abnormal_immune_system1.31705123
63MP0008569_lethality_at_weaning1.31304934
64MP0004858_abnormal_nervous_system1.30768466
65MP0002429_abnormal_blood_cell1.29848682
66MP0005058_abnormal_lysosome_morphology1.28331681
67MP0009046_muscle_twitch1.27946851
68MP0003195_calcinosis1.27670210
69MP0002396_abnormal_hematopoietic_system1.27251265
70MP0000604_amyloidosis1.24719560
71MP0008961_abnormal_basal_metabolism1.23814750
72MP0002736_abnormal_nociception_after1.23564464
73MP0002928_abnormal_bile_duct1.22422495
74MP0004142_abnormal_muscle_tone1.21122011
75MP0001533_abnormal_skeleton_physiology1.20887547
76MP0004811_abnormal_neuron_physiology1.13612315
77MP0004808_abnormal_hematopoietic_stem1.12310449
78MP0004381_abnormal_hair_follicle1.11548303
79MP0005423_abnormal_somatic_nervous1.11098263
80MP0001970_abnormal_pain_threshold1.09203097
81MP0002822_catalepsy1.08249591
82MP0002693_abnormal_pancreas_physiology1.08152350
83MP0008874_decreased_physiological_sensi1.07997903
84MP0003724_increased_susceptibility_to1.06461049
85MP0008872_abnormal_physiological_respon1.04796475
86MP0001853_heart_inflammation1.04386653
87MP0005166_decreased_susceptibility_to1.03778002
88MP0002933_joint_inflammation1.03664720
89MP0009333_abnormal_splenocyte_physiolog1.03027493
90MP0002277_abnormal_respiratory_mucosa1.02889808
91MP0003866_abnormal_defecation1.02456008
92MP0003633_abnormal_nervous_system1.00684580
93MP0002272_abnormal_nervous_system1.00561404
94MP0002733_abnormal_thermal_nociception1.00320725
95MP0005645_abnormal_hypothalamus_physiol0.99501986
96MP0001440_abnormal_grooming_behavior0.99083609
97MP0002909_abnormal_adrenal_gland0.98971466
98MP0003091_abnormal_cell_migration0.96939223
99MP0001486_abnormal_startle_reflex0.95277953
100MP0002998_abnormal_bone_remodeling0.94691788
101MP0003448_altered_tumor_morphology0.93177332
102MP0000015_abnormal_ear_pigmentation0.93025253
103MP0003787_abnormal_imprinting0.92740304
104MP0005167_abnormal_blood-brain_barrier0.92711046
105MP0003329_amyloid_beta_deposits0.90618302
106MP0003045_fibrosis0.88710522
107MP0002734_abnormal_mechanical_nocicepti0.84381065
108MP0000858_altered_metastatic_potential0.83389142
109MP0008469_abnormal_protein_level0.82673659
110MP0000230_abnormal_systemic_arterial0.81487103
111MP0005381_digestive/alimentary_phenotyp0.81413218
112MP0005075_abnormal_melanosome_morpholog0.81136224
113MP0005551_abnormal_eye_electrophysiolog0.81110761
114MP0004742_abnormal_vestibular_system0.79340023
115MP0001348_abnormal_lacrimal_gland0.79275585
116MP0000465_gastrointestinal_hemorrhage0.79248877
117MP0008004_abnormal_stomach_pH0.76135334
118MP0002067_abnormal_sensory_capabilities0.75832614
119MP0003879_abnormal_hair_cell0.75645215
120MP0001851_eye_inflammation0.75422847
121MP0005448_abnormal_energy_balance0.72588282
122MP0008877_abnormal_DNA_methylation0.71660871
123MP0000470_abnormal_stomach_morphology0.71200865
124MP0010386_abnormal_urinary_bladder0.71039974
125MP0005390_skeleton_phenotype0.70198518
126MP0003631_nervous_system_phenotype0.68031631
127MP0005084_abnormal_gallbladder_morpholo0.67080455
128MP0004885_abnormal_endolymph0.65812339
129MP0002184_abnormal_innervation0.64934050
130MP0002168_other_aberrant_phenotype0.63849449
131MP0002638_abnormal_pupillary_reflex0.62398248
132MP0002095_abnormal_skin_pigmentation0.61430742
133MP0000371_diluted_coat_color0.60975949

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.42713927
2Recurrent abscess formation (HP:0002722)4.34563594
3Stomatitis (HP:0010280)4.22695688
4Eczematoid dermatitis (HP:0000976)3.93912919
5Recurrent bacterial skin infections (HP:0005406)3.88887392
6Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.79077434
7Recurrent fungal infections (HP:0002841)3.59496103
8Recurrent viral infections (HP:0004429)3.47072208
9Focal motor seizures (HP:0011153)3.42438946
10Myokymia (HP:0002411)3.34095898
11Congenital stationary night blindness (HP:0007642)3.33309528
12Myositis (HP:0100614)3.33081952
13Chronic otitis media (HP:0000389)3.32902538
14Mediastinal lymphadenopathy (HP:0100721)3.26186090
15Pancreatic cysts (HP:0001737)3.18006668
16Visual hallucinations (HP:0002367)3.12586919
17Abnormality of midbrain morphology (HP:0002418)3.04620278
18Molar tooth sign on MRI (HP:0002419)3.04620278
19Abnormality of T cell number (HP:0011839)3.04310693
20Clumsiness (HP:0002312)3.04278242
21T lymphocytopenia (HP:0005403)3.02976734
22Agammaglobulinemia (HP:0004432)2.99615996
23Chronic mucocutaneous candidiasis (HP:0002728)2.98603529
24Recurrent cutaneous fungal infections (HP:0011370)2.98603529
25Hyperventilation (HP:0002883)2.97538181
26Focal seizures (HP:0007359)2.96058127
27Genetic anticipation (HP:0003743)2.95266765
28Cellulitis (HP:0100658)2.92971872
29Retrobulbar optic neuritis (HP:0100654)2.88218654
30Optic neuritis (HP:0100653)2.88218654
31Protruding tongue (HP:0010808)2.85986484
32Encephalitis (HP:0002383)2.85350356
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.81170435
34Panhypogammaglobulinemia (HP:0003139)2.80971784
35Recurrent skin infections (HP:0001581)2.75433858
36Chronic obstructive pulmonary disease (HP:0006510)2.67323353
37Obstructive lung disease (HP:0006536)2.67323353
38Meningitis (HP:0001287)2.65456239
39Supranuclear gaze palsy (HP:0000605)2.62486787
40Attenuation of retinal blood vessels (HP:0007843)2.62118023
41Orchitis (HP:0100796)2.61877363
42Vasculitis (HP:0002633)2.61274514
43Pancreatic fibrosis (HP:0100732)2.56587033
44Autoimmune thrombocytopenia (HP:0001973)2.56008209
45Increased cerebral lipofuscin (HP:0011813)2.54969282
46Recurrent bronchitis (HP:0002837)2.54480938
47Abnormality of macrophages (HP:0004311)2.51318976
48Absent/shortened dynein arms (HP:0200106)2.51148825
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.51148825
50Gingivitis (HP:0000230)2.50890468
51Pustule (HP:0200039)2.49561675
52Papilledema (HP:0001085)2.48770455
53Nephronophthisis (HP:0000090)2.48736377
54Polydipsia (HP:0001959)2.46521672
55Abnormal drinking behavior (HP:0030082)2.46521672
56Gastrointestinal infarctions (HP:0005244)2.44390816
57Recurrent gram-negative bacterial infections (HP:0005420)2.41136104
58Spontaneous hematomas (HP:0007420)2.39498426
59Febrile seizures (HP:0002373)2.38696034
60Thyroiditis (HP:0100646)2.38181687
61Leukocytosis (HP:0001974)2.38088821
62Recurrent sinusitis (HP:0011108)2.34758172
63Truncal ataxia (HP:0002078)2.32232367
64Urinary bladder sphincter dysfunction (HP:0002839)2.31922178
65Hypochromic anemia (HP:0001931)2.31908645
66True hermaphroditism (HP:0010459)2.31538507
67Inflammation of the large intestine (HP:0002037)2.30621034
68Decreased circulating renin level (HP:0003351)2.26973094
69Nasal polyposis (HP:0100582)2.26721115
70Colitis (HP:0002583)2.26181803
71Abnormality of T cells (HP:0002843)2.25711760
72Gastrointestinal inflammation (HP:0004386)2.25422045
73Stomach cancer (HP:0012126)2.24714810
74Large for gestational age (HP:0001520)2.24188300
75Pulmonary infiltrates (HP:0002113)2.22038434
76Inability to walk (HP:0002540)2.21119737
77Verrucae (HP:0200043)2.21113390
78Papilloma (HP:0012740)2.21113390
79Abnormality of T cell physiology (HP:0011840)2.19464950
80Progressive cerebellar ataxia (HP:0002073)2.19012936
81Eosinophilia (HP:0001880)2.17137305
82Gastrointestinal stroma tumor (HP:0100723)2.16499055
83Absence seizures (HP:0002121)2.16095473
84Atonic seizures (HP:0010819)2.15151304
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.13291402
86Ocular albinism (HP:0001107)2.13008959
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12891733
88Periodontitis (HP:0000704)2.12785477
89Keratoconjunctivitis (HP:0001096)2.10869911
90Abnormal rod and cone electroretinograms (HP:0008323)2.10570824
91Severe combined immunodeficiency (HP:0004430)2.10565839
92Chronic sinusitis (HP:0011109)2.10158393
93Diplopia (HP:0000651)2.09361163
94Abnormality of binocular vision (HP:0011514)2.09361163
95IgM deficiency (HP:0002850)2.09276684
96Loss of speech (HP:0002371)2.09208801
97Prolonged bleeding time (HP:0003010)2.07921351
98Abnormality of the renal medulla (HP:0100957)2.07744240
99Increased IgE level (HP:0003212)2.07501904
100Absent frontal sinuses (HP:0002688)2.07144443
101Frequent falls (HP:0002359)2.03197550
102Petechiae (HP:0000967)2.02862291
103Mutism (HP:0002300)2.02194911
104Cystic liver disease (HP:0006706)2.01175796
105Action tremor (HP:0002345)2.00951920
106Dialeptic seizures (HP:0011146)2.00590194
107Spinal canal stenosis (HP:0003416)2.00340741
108Abnormal platelet function (HP:0011869)2.00247371
109Impaired platelet aggregation (HP:0003540)2.00247371
110Lymphopenia (HP:0001888)1.99691188
111Patellar aplasia (HP:0006443)1.99417305
112Arterial thrombosis (HP:0004420)1.97553788
113Epileptic encephalopathy (HP:0200134)1.97197695
114Abnormality of cells of the lymphoid lineage (HP:0012140)1.96237858
115Type II lissencephaly (HP:0007260)1.95475066
116Tubular atrophy (HP:0000092)1.92881721
117Decreased central vision (HP:0007663)1.92822815
118Epistaxis (HP:0000421)1.91892171
119Chronic hepatic failure (HP:0100626)1.91345944
120Iris hypopigmentation (HP:0007730)1.91002836
121Pointed chin (HP:0000307)1.90903876
122Global brain atrophy (HP:0002283)1.90764497
123Abnormality of eosinophils (HP:0001879)1.89546038
124Abnormality of the fingertips (HP:0001211)1.88765950
125Hemiplegia (HP:0002301)1.88748411
126Inappropriate behavior (HP:0000719)1.87784959
127Albinism (HP:0001022)1.87427866
128Apathy (HP:0000741)1.87061436
129Abnormal respiratory epithelium morphology (HP:0012253)1.87010755
130Abnormal respiratory motile cilium morphology (HP:0005938)1.87010755
131Abnormality of the nasal mucosa (HP:0000433)1.85369653
132Hemoptysis (HP:0002105)1.84671415
133Dysostosis multiplex (HP:0000943)1.84135317
134Impaired smooth pursuit (HP:0007772)1.83824477
135Interstitial pulmonary disease (HP:0006530)1.83809576
136Aplasia/Hypoplasia of the patella (HP:0006498)1.83536459
137IgG deficiency (HP:0004315)1.83377830
138Abnormality of the renal cortex (HP:0011035)1.82292051
139Combined immunodeficiency (HP:0005387)1.82048259
140Episodic fever (HP:0001954)1.81838434
141Abnormality of B cell number (HP:0010975)1.81529283
142B lymphocytopenia (HP:0010976)1.81529283
143Granulocytopenia (HP:0001913)1.81279469
144Stereotypic behavior (HP:0000733)1.81250352
145Diminished motivation (HP:0000745)1.80330107
146Progressive inability to walk (HP:0002505)1.80177016
147Keratoconjunctivitis sicca (HP:0001097)1.78399557
148Bony spicule pigmentary retinopathy (HP:0007737)1.77651487
149Gaze-evoked nystagmus (HP:0000640)1.77318226
150Macroglossia (HP:0000158)1.77142832
151Abnormality of the pleura (HP:0002103)1.76290256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.31061899
2FRK4.18339418
3RIPK43.72512214
4MAP4K13.30052769
5NTRK32.86427881
6MAP3K142.62845829
7ADRBK22.56949208
8TLK12.47957636
9ACVR1B2.46362388
10MAP3K92.42119947
11SIK22.41224953
12FES2.37521987
13TXK2.35269954
14ERN12.03561349
15IKBKE1.98769164
16EPHA41.92716485
17BMPR1B1.87329633
18KSR21.84224315
19MAP3K111.82370630
20TBK11.80188062
21TYK21.75206422
22JAK11.68246179
23DAPK21.66545036
24IRAK41.61488454
25SYK1.61112137
26GRK61.59197317
27HCK1.53135557
28MAP2K31.50926385
29JAK31.50396759
30CAMKK11.48568906
31MAP3K121.45743387
32ZAP701.38567760
33IRAK11.36570441
34BLK1.29247482
35PRKCH1.28345431
36MAP3K101.25234708
37IRAK31.22584564
38DAPK11.22459024
39ITK1.22385334
40GRK11.21453522
41MAP3K71.20324599
42ADRBK11.19946508
43KIT1.19720169
44NTRK21.19447742
45MAPK151.12967363
46INSRR1.12639312
47RAF11.11283154
48MINK11.10192971
49PRPF4B1.10111798
50LCK1.08956818
51TAOK11.05885220
52IKBKB1.02869387
53EEF2K1.00898518
54CSK1.00666229
55PAK60.99145315
56CSF1R0.98618547
57TRIB30.98552631
58MAP2K60.97100568
59PDK10.96332702
60BTK0.95177516
61RPS6KA60.93873088
62SCYL20.93133384
63MAPK130.90711175
64CDC42BPA0.86239487
65PKN20.86129915
66CLK10.85921863
67MAP3K20.85149549
68ALK0.84707668
69MARK20.82724138
70JAK20.82664933
71CDK50.81586052
72KSR10.79865827
73MAPK120.79836615
74PRKCQ0.79469041
75ZAK0.78844996
76TNK20.77991708
77CAMKK20.76884987
78TGFBR10.76136936
79FGR0.73807471
80FGFR30.73193490
81EPHA30.73175566
82PTK2B0.72966335
83SIK30.72058419
84FYN0.71980700
85STK380.71336682
86RET0.70115544
87LYN0.68938682
88WNK40.67540577
89TEC0.65758294
90STK100.65096844
91IRAK20.64088590
92TYRO30.63758624
93MAP3K40.63151243
94MAP2K20.62704279
95EPHB10.62676254
96MAPK110.62616295
97MAP3K10.62301461
98CAMK10.60844019
99NLK0.60106215
100CHUK0.58276064
101MAPKAPK30.57260989
102PKN10.56883056
103STK110.56121464
104FGFR40.55875279
105RIPK10.54895697
106MARK10.54436407
107SGK10.54202138
108PRKD20.53787575
109PDPK10.53242478
110CAMK1D0.53184312
111PIK3CG0.52220990
112PINK10.51536268
113NTRK10.50459821
114PRKD30.49450135
115SGK30.49262438
116TAOK30.49201709
117ARAF0.48809759
118PDGFRB0.48543999
119PIM10.47832244
120MARK30.47731046
121CDK190.47619734
122RPS6KL10.47106092
123RPS6KC10.47106092
124NUAK10.47062799
125TGFBR20.46755486
126CAMK1G0.46202898
127RPS6KA20.46142254
128PTK60.44493827
129DMPK0.44169009
130TRPM70.43719466
131HIPK20.43273128
132MAPK40.41666992
133MATK0.41448946
134GRK50.40803095
135PRKCZ0.40571902
136MAPK70.40550109
137DAPK30.38212719
138MAP2K70.38062625
139TNIK0.37518310
140MELK0.37136397
141MAP3K30.34820424
142TIE10.32540924
143MAP2K40.31951649

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053202.17171120
2B cell receptor signaling pathway_Homo sapiens_hsa046621.95044229
3Olfactory transduction_Homo sapiens_hsa047401.85412460
4Osteoclast differentiation_Homo sapiens_hsa043801.83531401
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82281210
6Primary immunodeficiency_Homo sapiens_hsa053401.81507771
7Leishmaniasis_Homo sapiens_hsa051401.80696296
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74957269
9T cell receptor signaling pathway_Homo sapiens_hsa046601.68823738
10Long-term potentiation_Homo sapiens_hsa047201.66222954
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61709071
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.44700302
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41485741
14Synaptic vesicle cycle_Homo sapiens_hsa047211.40475727
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39883062
16Chemokine signaling pathway_Homo sapiens_hsa040621.38477846
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37864565
18Nicotine addiction_Homo sapiens_hsa050331.35248821
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34537230
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34233311
21Circadian entrainment_Homo sapiens_hsa047131.33631880
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28127618
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26943655
24Morphine addiction_Homo sapiens_hsa050321.26831967
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.25902160
26Tuberculosis_Homo sapiens_hsa051521.25454977
27Glutamatergic synapse_Homo sapiens_hsa047241.25062404
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23466231
29Type II diabetes mellitus_Homo sapiens_hsa049301.23236546
30TNF signaling pathway_Homo sapiens_hsa046681.20382101
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20378480
32Salivary secretion_Homo sapiens_hsa049701.18795368
33Gastric acid secretion_Homo sapiens_hsa049711.16737377
34Cholinergic synapse_Homo sapiens_hsa047251.16647626
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16617424
36Measles_Homo sapiens_hsa051621.16393626
37Amphetamine addiction_Homo sapiens_hsa050311.16217928
38Glioma_Homo sapiens_hsa052141.16051748
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16027428
40VEGF signaling pathway_Homo sapiens_hsa043701.15636560
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15492507
42Antigen processing and presentation_Homo sapiens_hsa046121.10553010
43Phototransduction_Homo sapiens_hsa047441.09770663
44Oxytocin signaling pathway_Homo sapiens_hsa049211.07975741
45Pertussis_Homo sapiens_hsa051331.07639565
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07376167
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06757475
48Shigellosis_Homo sapiens_hsa051311.06615399
49Linoleic acid metabolism_Homo sapiens_hsa005911.06577831
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06249795
51Dopaminergic synapse_Homo sapiens_hsa047281.05787056
52Hematopoietic cell lineage_Homo sapiens_hsa046401.04880284
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04681970
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04370665
55Nitrogen metabolism_Homo sapiens_hsa009101.01560146
56Platelet activation_Homo sapiens_hsa046111.01279460
57Graft-versus-host disease_Homo sapiens_hsa053320.99783400
58GnRH signaling pathway_Homo sapiens_hsa049120.99775034
59Toxoplasmosis_Homo sapiens_hsa051450.97894974
60Acute myeloid leukemia_Homo sapiens_hsa052210.97552284
61Chronic myeloid leukemia_Homo sapiens_hsa052200.97458298
62Influenza A_Homo sapiens_hsa051640.96728056
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95295103
64Hepatitis B_Homo sapiens_hsa051610.95018380
65Type I diabetes mellitus_Homo sapiens_hsa049400.94786930
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94571634
67GABAergic synapse_Homo sapiens_hsa047270.93922461
68ABC transporters_Homo sapiens_hsa020100.93125971
69Allograft rejection_Homo sapiens_hsa053300.92886409
70Salmonella infection_Homo sapiens_hsa051320.92749246
71African trypanosomiasis_Homo sapiens_hsa051430.92252893
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.91233421
73Non-small cell lung cancer_Homo sapiens_hsa052230.90369230
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89906356
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89734104
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88599369
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.88181490
78Pancreatic cancer_Homo sapiens_hsa052120.87942787
79* Calcium signaling pathway_Homo sapiens_hsa040200.87124140
80Long-term depression_Homo sapiens_hsa047300.86345674
81Renin secretion_Homo sapiens_hsa049240.84854655
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84507529
83Insulin secretion_Homo sapiens_hsa049110.83378789
84Estrogen signaling pathway_Homo sapiens_hsa049150.81413055
85ErbB signaling pathway_Homo sapiens_hsa040120.81253458
86MAPK signaling pathway_Homo sapiens_hsa040100.80436262
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79970532
88Ether lipid metabolism_Homo sapiens_hsa005650.79766226
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79146087
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.79058540
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.78642261
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.78516853
93mTOR signaling pathway_Homo sapiens_hsa041500.78207960
94Prolactin signaling pathway_Homo sapiens_hsa049170.78078002
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78015686
96Apoptosis_Homo sapiens_hsa042100.77222776
97cAMP signaling pathway_Homo sapiens_hsa040240.77102159
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76921322
99Herpes simplex infection_Homo sapiens_hsa051680.76417878
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76319932
101Rheumatoid arthritis_Homo sapiens_hsa053230.76120237
102Pancreatic secretion_Homo sapiens_hsa049720.76101727
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74503982
104Legionellosis_Homo sapiens_hsa051340.73511020
105Choline metabolism in cancer_Homo sapiens_hsa052310.73047052
106Dorso-ventral axis formation_Homo sapiens_hsa043200.72158934
107Lysosome_Homo sapiens_hsa041420.71928653
108Colorectal cancer_Homo sapiens_hsa052100.70552553
109Endocytosis_Homo sapiens_hsa041440.69493284
110Inositol phosphate metabolism_Homo sapiens_hsa005620.69313629
111Cocaine addiction_Homo sapiens_hsa050300.69269265
112Serotonergic synapse_Homo sapiens_hsa047260.67701705
113Malaria_Homo sapiens_hsa051440.67184112
114Asthma_Homo sapiens_hsa053100.66721502
115Hepatitis C_Homo sapiens_hsa051600.64300477
116Rap1 signaling pathway_Homo sapiens_hsa040150.63305874
117Viral myocarditis_Homo sapiens_hsa054160.62990570
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61042869
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60802521
120Staphylococcus aureus infection_Homo sapiens_hsa051500.60733490
121Arachidonic acid metabolism_Homo sapiens_hsa005900.60614640
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60037038
123Taste transduction_Homo sapiens_hsa047420.59806264
124Ovarian steroidogenesis_Homo sapiens_hsa049130.58814971
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.56676888
126Phagosome_Homo sapiens_hsa041450.55067922
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54475764
128Notch signaling pathway_Homo sapiens_hsa043300.52969800
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52582717
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51901197
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.51692662
132Homologous recombination_Homo sapiens_hsa034400.48075623
133Epstein-Barr virus infection_Homo sapiens_hsa051690.46156296
134FoxO signaling pathway_Homo sapiens_hsa040680.44337191

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