OR8G5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.82642082
2regulation of retinoic acid receptor signaling pathway (GO:0048385)9.05503790
3piRNA metabolic process (GO:0034587)8.85842864
4regulation of meiosis I (GO:0060631)7.92338988
5meiotic cell cycle (GO:0051321)7.81315124
6regulation of acrosome reaction (GO:0060046)7.44565767
7oocyte development (GO:0048599)6.82084172
8mitotic chromosome condensation (GO:0007076)6.59077466
9female gamete generation (GO:0007292)6.56078890
10multicellular organism reproduction (GO:0032504)6.40777357
11DNA methylation involved in gamete generation (GO:0043046)6.40098731
12synapsis (GO:0007129)6.28916020
13glycine transport (GO:0015816)6.14536538
14positive regulation of histone H3-K4 methylation (GO:0051571)5.82963704
15regulation of histone H3-K9 methylation (GO:0051570)5.56285336
16gene silencing by RNA (GO:0031047)5.26114045
17retinal cone cell development (GO:0046549)5.18567897
18protein kinase C signaling (GO:0070528)5.02858857
19regulation of steroid hormone secretion (GO:2000831)4.97070346
20negative regulation of reproductive process (GO:2000242)4.96465779
21mitotic metaphase plate congression (GO:0007080)4.90390531
22negative regulation of histone methylation (GO:0031061)4.83317327
23protein localization to chromosome, centromeric region (GO:0071459)4.73032179
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58787069
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.53417965
26regulation of cell maturation (GO:1903429)4.44792944
27positive regulation of humoral immune response (GO:0002922)4.41187698
28positive regulation of uterine smooth muscle contraction (GO:0070474)4.40305152
29L-amino acid import (GO:0043092)4.38953202
30positive regulation of chromosome segregation (GO:0051984)4.33509045
31CENP-A containing nucleosome assembly (GO:0034080)4.31799382
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.25747013
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.25747013
34positive regulation of mitotic sister chromatid separation (GO:1901970)4.25747013
35reproduction (GO:0000003)4.25439959
36protein localization to kinetochore (GO:0034501)4.24624041
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.19531977
38oogenesis (GO:0048477)4.18777713
39male meiosis I (GO:0007141)4.17591609
40attachment of spindle microtubules to kinetochore (GO:0008608)4.10253197
41chromosome organization involved in meiosis (GO:0070192)4.05209512
42regulation of meiosis (GO:0040020)4.05182007
43positive regulation of reproductive process (GO:2000243)4.03735731
44gonadal mesoderm development (GO:0007506)4.03669834
45establishment of chromosome localization (GO:0051303)3.97832107
46chromatin remodeling at centromere (GO:0031055)3.95788987
47metaphase plate congression (GO:0051310)3.91504039
48regulation of spindle organization (GO:0090224)3.91231510
49binding of sperm to zona pellucida (GO:0007339)3.84856780
50positive regulation of gastrulation (GO:2000543)3.82252763
51regulation of cytokine production involved in inflammatory response (GO:1900015)3.81460200
52male meiosis (GO:0007140)3.80128297
53translesion synthesis (GO:0019985)3.71158883
54regulation of histone H3-K4 methylation (GO:0051569)3.70083923
55DNA replication checkpoint (GO:0000076)3.65985071
56meiotic cell cycle process (GO:1903046)3.61924793
57phosphorelay signal transduction system (GO:0000160)3.61723891
58N-terminal protein amino acid acetylation (GO:0006474)3.61630628
59hyperosmotic salinity response (GO:0042538)3.60614293
60primitive streak formation (GO:0090009)3.60162078
61negative regulation of execution phase of apoptosis (GO:1900118)3.59961990
62DNA replication-dependent nucleosome organization (GO:0034723)3.54193119
63DNA replication-dependent nucleosome assembly (GO:0006335)3.54193119
64meiotic nuclear division (GO:0007126)3.51560591
65positive regulation of histone methylation (GO:0031062)3.50770931
66centriole replication (GO:0007099)3.49021330
67meiosis I (GO:0007127)3.46845986
68regulation of meiotic cell cycle (GO:0051445)3.42988895
69protein localization to chromosome (GO:0034502)3.42025847
70histone exchange (GO:0043486)3.41380723
71fertilization (GO:0009566)3.38051370
72gene silencing (GO:0016458)3.37975334
73DNA replication-independent nucleosome assembly (GO:0006336)3.37592201
74DNA replication-independent nucleosome organization (GO:0034724)3.37592201
75nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.35971638
76citrulline biosynthetic process (GO:0019240)3.34048098
77phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.33196109
78pyrimidine-containing compound transmembrane transport (GO:0072531)3.32473167
79regulation of histone methylation (GO:0031060)3.31652028
80regulation of uterine smooth muscle contraction (GO:0070472)3.31429610
81aggressive behavior (GO:0002118)3.30768230
82synaptonemal complex assembly (GO:0007130)3.28945730
83regulation of female receptivity (GO:0045924)3.28517422
84nuclear pore organization (GO:0006999)3.26870182
85DNA alkylation (GO:0006305)3.26708448
86DNA methylation (GO:0006306)3.26708448
87chromatin assembly or disassembly (GO:0006333)3.25220791
88DNA damage induced protein phosphorylation (GO:0006975)3.22609768
89regulation of spindle checkpoint (GO:0090231)3.19068947
90positive regulation of meiosis (GO:0045836)3.16744486
91chromatin assembly (GO:0031497)3.13681720
92regulation of reproductive process (GO:2000241)3.13014672
93sperm-egg recognition (GO:0035036)3.11392599
94cellular response to pH (GO:0071467)3.10961641
95single fertilization (GO:0007338)3.05943725
96folic acid transport (GO:0015884)3.05422725
97labyrinthine layer development (GO:0060711)3.05219536
98positive regulation of meiotic cell cycle (GO:0051446)3.05047990
99negative regulation of retinoic acid receptor signaling pathway (GO:0048387)10.6039728
100regulation of DNA methylation (GO:0044030)10.5762944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.35762882
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.55369708
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.02228255
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.02228255
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.02228255
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.78379528
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.12246728
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.09420083
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08541523
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01257324
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.78715696
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.54524869
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51724661
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40230765
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.39153610
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37233576
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36046118
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18696371
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14463062
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.07296691
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.06416665
22AR_21909140_ChIP-Seq_LNCAP_Human2.00123073
23EZH2_22144423_ChIP-Seq_EOC_Human12.8878109
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90559950
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65965475
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46231444
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.45547314
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42267274
29IRF1_19129219_ChIP-ChIP_H3396_Human1.41609945
30ZNF274_21170338_ChIP-Seq_K562_Hela1.32410419
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.30441984
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.30284804
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19501770
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.13767851
35GBX2_23144817_ChIP-Seq_PC3_Human1.13189840
36FOXP3_21729870_ChIP-Seq_TREG_Human1.12898769
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11854955
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09913035
39HTT_18923047_ChIP-ChIP_STHdh_Human1.07499296
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.06334389
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05864325
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04421873
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04148301
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03257125
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01945236
46* NANOG_20526341_ChIP-Seq_ESCs_Human0.98699458
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96422613
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96279516
49MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92790958
50PRDM14_20953172_ChIP-Seq_ESCs_Human0.90153357
51SALL4_22934838_ChIP-ChIP_CD34+_Human0.90085642
52TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89629812
53CBP_20019798_ChIP-Seq_JUKART_Human0.89457989
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89457989
55FOXH1_21741376_ChIP-Seq_EPCs_Human0.87091939
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86883138
57PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86563215
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85806913
59ESR1_20079471_ChIP-ChIP_T-47D_Human0.85142123
60VDR_23849224_ChIP-Seq_CD4+_Human0.82186863
61TCF4_23295773_ChIP-Seq_U87_Human0.81435271
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80478456
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78702715
64CBP_21632823_ChIP-Seq_H3396_Human0.78609153
65NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78405686
66FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77490858
67AR_25329375_ChIP-Seq_VCAP_Human0.77364906
68GF1_26923725_Chip-Seq_HPCs_Mouse0.75983284
69ETS1_20019798_ChIP-Seq_JURKAT_Human0.75831160
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75523995
71EP300_21415370_ChIP-Seq_HL-1_Mouse0.74617863
72GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73770623
73PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72499293
74SMAD4_21741376_ChIP-Seq_EPCs_Human0.72186522
75TFEB_21752829_ChIP-Seq_HELA_Human0.72171887
76E2F1_21310950_ChIP-Seq_MCF-7_Human0.71976246
77MYC_18940864_ChIP-ChIP_HL60_Human0.71831086
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.71595481
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70886892
80EWS_26573619_Chip-Seq_HEK293_Human0.70561907
81TP53_22573176_ChIP-Seq_HFKS_Human0.68675151
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.68393366
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68109395
84RUNX2_22187159_ChIP-Seq_PCA_Human0.68093679
85ERG_20517297_ChIP-Seq_VCAP_Human0.67817869
86AR_20517297_ChIP-Seq_VCAP_Human0.67104131
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.63782321
88GATA3_26560356_Chip-Seq_TH1_Human0.63565767
89E2F1_17053090_ChIP-ChIP_MCF-7_Human0.62600435
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.62498152
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.62258469
92MYC_18555785_ChIP-Seq_MESCs_Mouse0.61592550
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.61289220
94MYCN_18555785_ChIP-Seq_MESCs_Mouse0.60442825
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.60120606
96SMRT_27268052_Chip-Seq_Bcells_Human0.60093362
97MYC_19030024_ChIP-ChIP_MESCs_Mouse0.58950057
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58591138
99BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.58385299
100AHR_22903824_ChIP-Seq_MCF-7_Human0.58010656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.35572007
2MP0008877_abnormal_DNA_methylation4.11541936
3MP0006292_abnormal_olfactory_placode3.90433302
4MP0008789_abnormal_olfactory_epithelium3.47255752
5MP0005395_other_phenotype3.39022389
6MP0003693_abnormal_embryo_hatching3.25256768
7MP0005360_urolithiasis3.22524550
8MP0005394_taste/olfaction_phenotype3.22251852
9MP0005499_abnormal_olfactory_system3.22251852
10MP0008057_abnormal_DNA_replication3.18891711
11MP0010234_abnormal_vibrissa_follicle3.13304297
12MP0003890_abnormal_embryonic-extraembry2.98016350
13MP0002139_abnormal_hepatobiliary_system2.96365534
14MP0009840_abnormal_foam_cell2.61368253
15MP0003879_abnormal_hair_cell2.51333294
16MP0001929_abnormal_gametogenesis2.48269196
17MP0003699_abnormal_female_reproductive2.44621708
18MP0002210_abnormal_sex_determination2.43508218
19MP0003950_abnormal_plasma_membrane2.36719444
20MP0003077_abnormal_cell_cycle2.35947016
21MP0010030_abnormal_orbit_morphology2.29311288
22MP0010094_abnormal_chromosome_stability2.20074209
23MP0008058_abnormal_DNA_repair2.11878371
24MP0005410_abnormal_fertilization2.10060760
25MP0002138_abnormal_hepatobiliary_system2.06723664
26MP0003111_abnormal_nucleus_morphology2.00946997
27MP0000653_abnormal_sex_gland1.86404770
28MP0010307_abnormal_tumor_latency1.78575943
29MP0002160_abnormal_reproductive_system1.77441862
30MP0010368_abnormal_lymphatic_system1.75025937
31MP0002234_abnormal_pharynx_morphology1.70251259
32MP0002161_abnormal_fertility/fecundity1.69357014
33MP0005647_abnormal_sex_gland1.64106084
34MP0008932_abnormal_embryonic_tissue1.62975614
35MP0001145_abnormal_male_reproductive1.56304897
36MP0005646_abnormal_pituitary_gland1.45416872
37MP0001730_embryonic_growth_arrest1.41495669
38MP0000566_synostosis1.37603295
39MP0003183_abnormal_peptide_metabolism1.36025770
40MP0001119_abnormal_female_reproductive1.33542468
41MP0003698_abnormal_male_reproductive1.29898853
42MP0004957_abnormal_blastocyst_morpholog1.26468776
43MP0002796_impaired_skin_barrier1.24707566
44MP0005389_reproductive_system_phenotype1.19119195
45MP0004142_abnormal_muscle_tone1.13460641
46MP0009379_abnormal_foot_pigmentation1.11979242
47MP0000631_abnormal_neuroendocrine_gland1.11680184
48MP0001672_abnormal_embryogenesis/_devel1.04674842
49MP0005380_embryogenesis_phenotype1.04674842
50MP0001293_anophthalmia1.03687990
51MP0000427_abnormal_hair_cycle1.03312037
52MP0000762_abnormal_tongue_morphology1.02449836
53MP0000350_abnormal_cell_proliferation1.02149880
54MP0010678_abnormal_skin_adnexa1.01299328
55MP0003252_abnormal_bile_duct1.00598616
56MP0001986_abnormal_taste_sensitivity0.98382693
57MP0003136_yellow_coat_color0.98222284
58MP0005501_abnormal_skin_physiology0.92548614
59MP0005085_abnormal_gallbladder_physiolo0.90700179
60MP0006276_abnormal_autonomic_nervous0.90319986
61MP0003121_genomic_imprinting0.88786939
62MP0005075_abnormal_melanosome_morpholog0.82103860
63MP0003941_abnormal_skin_development0.80038681
64MP0000678_abnormal_parathyroid_gland0.80004993
65MP0001666_abnormal_nutrient_absorption0.78655063
66MP0002233_abnormal_nose_morphology0.76946847
67MP0002272_abnormal_nervous_system0.72285391
68MP0001881_abnormal_mammary_gland0.71734120
69MP0003119_abnormal_digestive_system0.71373530
70MP0003959_abnormal_lean_body0.66701173
71MP0001664_abnormal_digestion0.64425172
72MP0001324_abnormal_eye_pigmentation0.63938879
73MP0001984_abnormal_olfaction0.63049504
74MP0004381_abnormal_hair_follicle0.60448902
75MP0005076_abnormal_cell_differentiation0.59630185
76MP0001502_abnormal_circadian_rhythm0.59446437
77MP0001697_abnormal_embryo_size0.58964372
78MP0002084_abnormal_developmental_patter0.58603582
79MP0002127_abnormal_cardiovascular_syste0.58504796
80MP0002090_abnormal_vision0.57731208
81MP0005551_abnormal_eye_electrophysiolog0.55462188
82MP0000313_abnormal_cell_death0.54473838
83MP0004233_abnormal_muscle_weight0.53839914
84MP0003984_embryonic_growth_retardation0.51420394
85MP0002277_abnormal_respiratory_mucosa0.50656892
86MP0000015_abnormal_ear_pigmentation0.49330309
87MP0005319_abnormal_enzyme/_coenzyme0.49220137
88MP0002088_abnormal_embryonic_growth/wei0.48553049
89MP0002085_abnormal_embryonic_tissue0.47067706
90MP0008995_early_reproductive_senescence0.45751169
91MP0005174_abnormal_tail_pigmentation0.44380731
92MP0006138_congestive_heart_failure0.44094212
93MP0002080_prenatal_lethality0.43502946
94MP0002095_abnormal_skin_pigmentation0.43213871
95MP0000377_abnormal_hair_follicle0.43068980
96MP0003936_abnormal_reproductive_system0.42201083
97MP0002873_normal_phenotype0.39912765
98MP0000049_abnormal_middle_ear0.39364563
99MP0002169_no_abnormal_phenotype0.39324224
100MP0001963_abnormal_hearing_physiology0.37990585

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)5.67111232
2Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.50798490
3Cholecystitis (HP:0001082)5.24553525
4Abnormal gallbladder physiology (HP:0012438)5.24553525
5Supernumerary spleens (HP:0009799)5.16005977
6Osteomalacia (HP:0002749)4.91549637
7Abdominal situs inversus (HP:0003363)4.50064588
8Abnormality of abdominal situs (HP:0011620)4.50064588
9Hypophosphatemic rickets (HP:0004912)4.48142582
10Premature ovarian failure (HP:0008209)4.34286586
11Hypoplasia of the fovea (HP:0007750)4.29863457
12Aplasia/Hypoplasia of the fovea (HP:0008060)4.29863457
13Malnutrition (HP:0004395)4.22754493
14Lip pit (HP:0100267)4.02733046
15Infertility (HP:0000789)3.99048650
16Facial hemangioma (HP:0000329)3.96132654
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91309137
18Hypokinesia (HP:0002375)3.88020862
19Chromsome breakage (HP:0040012)3.84300517
20Azoospermia (HP:0000027)3.76797536
21Papillary thyroid carcinoma (HP:0002895)3.74193919
22Impulsivity (HP:0100710)3.67008302
23Abnormality of the fovea (HP:0000493)3.65050749
24Anterior segment dysgenesis (HP:0007700)3.55095940
25Apathy (HP:0000741)3.47856470
26Gonadotropin excess (HP:0000837)3.47668523
27Diminished motivation (HP:0000745)3.42433940
28Short tibia (HP:0005736)3.34543809
29Loss of speech (HP:0002371)3.25333990
30Septo-optic dysplasia (HP:0100842)3.20594004
31Median cleft lip (HP:0000161)3.17877782
32Oligodactyly (hands) (HP:0001180)3.16170073
33Absent septum pellucidum (HP:0001331)3.14153796
34Conjunctival telangiectasia (HP:0000524)2.96442568
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.91761558
36Abnormal spermatogenesis (HP:0008669)2.91630515
37Muscle stiffness (HP:0003552)2.90195295
38Metaphyseal irregularity (HP:0003025)2.86286115
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.85126155
40Generalized aminoaciduria (HP:0002909)2.83043618
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.80340873
42Abnormality of the labia minora (HP:0012880)2.78973355
43Proximal tubulopathy (HP:0000114)2.73992765
44Abnormality of the septum pellucidum (HP:0007375)2.66516974
45Lower limb hyperreflexia (HP:0002395)2.65670848
46Urethral obstruction (HP:0000796)2.62385011
47Aplasia/Hypoplasia of the macula (HP:0008059)2.55745388
48Capillary hemangiomas (HP:0005306)2.49884914
49Aplasia of the musculature (HP:0100854)2.48733555
50Spinal cord compression (HP:0002176)2.45847590
51Abnormality of the vasculature of the conjunctiva (HP:0008054)2.43322562
52Truncal obesity (HP:0001956)2.38313912
53Nausea (HP:0002018)2.37593131
54Oligodactyly (HP:0012165)2.37586048
55Skin pits (HP:0100276)2.35753295
56Sensory axonal neuropathy (HP:0003390)2.32798330
57Aplasia/Hypoplasia affecting the retina (HP:0008061)2.32750789
58Intrahepatic cholestasis (HP:0001406)2.24033334
59Multiple enchondromatosis (HP:0005701)2.20288405
60Abnormality of the phalanges of the hallux (HP:0010057)2.19374144
61Stillbirth (HP:0003826)2.16918779
62Steatorrhea (HP:0002570)2.16292449
63Myokymia (HP:0002411)2.13857611
64Bundle branch block (HP:0011710)2.08828532
65Microglossia (HP:0000171)2.07663432
66Abnormal lung lobation (HP:0002101)2.04392345
67Thyroid carcinoma (HP:0002890)2.04306158
68Congenital ichthyosiform erythroderma (HP:0007431)2.02714875
69Limb hypertonia (HP:0002509)2.01221808
70Anhidrosis (HP:0000970)2.01134896
71Enlarged penis (HP:0000040)1.99968171
72Rickets (HP:0002748)1.99357361
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.98169915
74Abnormality of the preputium (HP:0100587)1.92435239
75Aplastic anemia (HP:0001915)1.92372259
76Wrist flexion contracture (HP:0001239)1.91028626
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.91019775
78Hypergonadotropic hypogonadism (HP:0000815)1.90596790
79Bile duct proliferation (HP:0001408)1.88498313
80Abnormal biliary tract physiology (HP:0012439)1.88498313
81Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87893141
82Abnormality of chromosome stability (HP:0003220)1.87337403
83Birth length less than 3rd percentile (HP:0003561)1.86923176
84Fair hair (HP:0002286)1.85119304
85Rhinitis (HP:0012384)1.84112676
86Posterior subcapsular cataract (HP:0007787)1.82025589
87Abnormality of the salivary glands (HP:0010286)1.79196260
88Abnormal ciliary motility (HP:0012262)1.79045015
89Diminished movement (HP:0002374)1.78320566
90Meckel diverticulum (HP:0002245)1.77024817
91Hypohidrosis (HP:0000966)1.75060758
92Heterotopia (HP:0002282)1.75004212
93Small intestinal stenosis (HP:0012848)1.72717599
94Duodenal stenosis (HP:0100867)1.72717599
95Cranial hyperostosis (HP:0004437)1.71838172
96Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71758655
97Mutism (HP:0002300)1.71704356
98Striae distensae (HP:0001065)1.71210477
99Absent radius (HP:0003974)1.70990332
100Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69839000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.15853734
2ARAF5.75003246
3MAP3K135.65381382
4NEK63.21755060
5KSR22.98718062
6BRAF2.97981148
7TTK2.91471132
8STK242.75915532
9TAOK32.50856319
10MOS2.40211819
11EIF2AK32.29442558
12RAF12.23678219
13CDC72.09115035
14AURKA1.95225121
15BUB11.90039719
16MET1.82208303
17ACVR1B1.79518728
18CDK191.76893769
19TRIM281.61743258
20CDK91.59132793
21CDK121.55923038
22CDK71.47941177
23STK31.44331048
24PRKCI1.42591385
25KSR11.41665325
26PLK11.38467564
27BRSK11.34725857
28MAP3K81.23573600
29ZAK1.19803982
30BMPR1B1.18310878
31MELK1.15554531
32NEK21.14425675
33WNK11.04131881
34BRSK21.02131024
35TESK21.01812523
36NTRK31.01578578
37PIM11.00108299
38NTRK20.98690829
39MARK30.94903587
40CDK80.94895680
41SRPK10.90432882
42MAPKAPK30.87308929
43CHEK10.82249234
44PLK30.77494809
45TGFBR10.76496441
46STK390.76409328
47AURKB0.75103405
48TNIK0.74932753
49PBK0.70925298
50NEK90.70477228
51CHEK20.67708992
52DMPK0.66273518
53CDK20.65232933
54PTK20.64983713
55EEF2K0.63545365
56PAK10.62887203
57TNK20.59746136
58LRRK20.57480294
59MST40.55007438
60ATR0.52974311
61TIE10.52955591
62WNK40.52721385
63NUAK10.50146892
64CDK10.49960391
65ATM0.49715458
66PKN10.48230606
67MAP2K10.46900054
68RPS6KB20.45224206
69MAP3K50.42282290
70PRKG10.40882595
71CLK10.39184601
72LATS20.36536635
73MTOR0.36094473
74PDK10.35235889
75MAP3K10.35103861
76CSNK1E0.34400369
77TLK10.34036292
78MAP3K40.33688409
79TRPM70.33343849
80CSNK1D0.30579044
81BMPR20.30166674
82CSNK1G10.29201269
83PRKACB0.28258299
84VRK10.27947481
85AKT20.27210891
86WEE10.22523178
87PDPK10.22187773
88CSNK2A20.22117496
89CDK11A0.21053691
90PIK3CA0.20614168
91EIF2AK10.20157614
92GSK3B0.19238480
93PRKCZ0.18171170
94MAPK10.17817115
95MAPK130.17001389
96CAMK2A0.15477677
97CSNK2A10.13249892
98CCNB10.13068117
99EGFR0.12651094
100STK40.12298116

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.82959843
2Cell cycle_Homo sapiens_hsa041104.56430180
3Mismatch repair_Homo sapiens_hsa034304.42504063
4Base excision repair_Homo sapiens_hsa034103.59403361
5Oocyte meiosis_Homo sapiens_hsa041143.37973416
6DNA replication_Homo sapiens_hsa030303.33600772
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.31213351
8Nucleotide excision repair_Homo sapiens_hsa034202.72486805
9Caffeine metabolism_Homo sapiens_hsa002322.71005460
10Ovarian steroidogenesis_Homo sapiens_hsa049132.65778047
11RNA degradation_Homo sapiens_hsa030182.59572531
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.58109979
13Dorso-ventral axis formation_Homo sapiens_hsa043202.53669132
14Fanconi anemia pathway_Homo sapiens_hsa034602.31389712
15Homologous recombination_Homo sapiens_hsa034402.29732180
16RNA transport_Homo sapiens_hsa030132.24917201
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12909902
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.96556493
19Folate biosynthesis_Homo sapiens_hsa007901.91641691
20RNA polymerase_Homo sapiens_hsa030201.79989552
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79775211
22p53 signaling pathway_Homo sapiens_hsa041151.64078375
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51349312
24mRNA surveillance pathway_Homo sapiens_hsa030151.51233059
25Fatty acid elongation_Homo sapiens_hsa000621.48072937
26Thyroid cancer_Homo sapiens_hsa052161.34939433
27Circadian rhythm_Homo sapiens_hsa047101.32226127
28ABC transporters_Homo sapiens_hsa020101.14293307
29Gap junction_Homo sapiens_hsa045401.00290518
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97144385
31* Olfactory transduction_Homo sapiens_hsa047400.96267669
32Glycosaminoglycan degradation_Homo sapiens_hsa005310.95662288
33SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88423787
34Synaptic vesicle cycle_Homo sapiens_hsa047210.84816907
35Collecting duct acid secretion_Homo sapiens_hsa049660.78165058
36Viral carcinogenesis_Homo sapiens_hsa052030.73197998
37Regulation of autophagy_Homo sapiens_hsa041400.71761910
38Phototransduction_Homo sapiens_hsa047440.69027391
39Taste transduction_Homo sapiens_hsa047420.66883772
40mTOR signaling pathway_Homo sapiens_hsa041500.65696929
41Purine metabolism_Homo sapiens_hsa002300.65406956
42Inositol phosphate metabolism_Homo sapiens_hsa005620.64164596
43Ribosome_Homo sapiens_hsa030100.63266727
44Pyrimidine metabolism_Homo sapiens_hsa002400.63171539
45Spliceosome_Homo sapiens_hsa030400.56531600
46Bile secretion_Homo sapiens_hsa049760.55244520
47Propanoate metabolism_Homo sapiens_hsa006400.53585687
48Nicotine addiction_Homo sapiens_hsa050330.47663795
49Morphine addiction_Homo sapiens_hsa050320.44146742
50TGF-beta signaling pathway_Homo sapiens_hsa043500.44075410
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43588436
52Arginine biosynthesis_Homo sapiens_hsa002200.42263506
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40440040
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37789895
55Huntingtons disease_Homo sapiens_hsa050160.37413722
56FoxO signaling pathway_Homo sapiens_hsa040680.36975488
57MicroRNAs in cancer_Homo sapiens_hsa052060.36330794
58Pyruvate metabolism_Homo sapiens_hsa006200.35683200
59Steroid biosynthesis_Homo sapiens_hsa001000.34821561
60Serotonergic synapse_Homo sapiens_hsa047260.33677775
61GABAergic synapse_Homo sapiens_hsa047270.33317034
62Long-term depression_Homo sapiens_hsa047300.32868311
63Phagosome_Homo sapiens_hsa041450.32182216
64Herpes simplex infection_Homo sapiens_hsa051680.28465208
65Lysosome_Homo sapiens_hsa041420.26423973
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25385977
67ErbB signaling pathway_Homo sapiens_hsa040120.25167126
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24264696
69HTLV-I infection_Homo sapiens_hsa051660.23710469
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23481892
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23336076
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23326470
73Vitamin digestion and absorption_Homo sapiens_hsa049770.21836787
74Vibrio cholerae infection_Homo sapiens_hsa051100.21807184
75Adherens junction_Homo sapiens_hsa045200.20694003
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20509353
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20190078
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.18845024
79Hepatitis B_Homo sapiens_hsa051610.16651992
80Renal cell carcinoma_Homo sapiens_hsa052110.15594099
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14180401
82Small cell lung cancer_Homo sapiens_hsa052220.13111537
83Arginine and proline metabolism_Homo sapiens_hsa003300.10786266
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.09473797
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09089523
86Epstein-Barr virus infection_Homo sapiens_hsa051690.08772448
87Metabolic pathways_Homo sapiens_hsa011000.07348883
88Non-homologous end-joining_Homo sapiens_hsa034500.06920651
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.05400355
90Ras signaling pathway_Homo sapiens_hsa040140.04667350
91Non-small cell lung cancer_Homo sapiens_hsa052230.03016521
92HIF-1 signaling pathway_Homo sapiens_hsa040660.02548853
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02274878
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.02269231
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.01726179
96Cardiac muscle contraction_Homo sapiens_hsa042600.01303876
97Proteasome_Homo sapiens_hsa030500.00250842
98Endometrial cancer_Homo sapiens_hsa05213-0.0250143
99Prion diseases_Homo sapiens_hsa05020-0.0162592
100Glutathione metabolism_Homo sapiens_hsa00480-0.0043848

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »