OR6M1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.95055341
2protein-cofactor linkage (GO:0018065)5.17646381
3phosphorelay signal transduction system (GO:0000160)4.93038504
4behavioral response to nicotine (GO:0035095)4.69401551
5rhodopsin mediated signaling pathway (GO:0016056)4.50955080
6positive regulation of T cell cytokine production (GO:0002726)4.38968536
7interferon-gamma production (GO:0032609)4.37339522
8multicellular organism reproduction (GO:0032504)4.29971699
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20544400
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.20544400
11NADH dehydrogenase complex assembly (GO:0010257)4.20544400
12indolalkylamine metabolic process (GO:0006586)4.14315225
13platelet dense granule organization (GO:0060155)4.09922662
14mechanosensory behavior (GO:0007638)4.01974011
15protein complex biogenesis (GO:0070271)3.93510242
16respiratory chain complex IV assembly (GO:0008535)3.91208811
17positive regulation of T cell chemotaxis (GO:0010820)3.77876713
18regulation of T cell chemotaxis (GO:0010819)3.77876713
19ubiquinone metabolic process (GO:0006743)3.72205301
20regulation of rhodopsin mediated signaling pathway (GO:0022400)3.65174922
21DNA double-strand break processing (GO:0000729)3.51439915
22mannosylation (GO:0097502)3.51065405
23DNA deamination (GO:0045006)3.47768801
24negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47358139
25mitochondrial respiratory chain complex assembly (GO:0033108)3.47129634
26cytochrome complex assembly (GO:0017004)3.39141474
27negative regulation of T cell mediated immunity (GO:0002710)3.39064647
28ubiquinone biosynthetic process (GO:0006744)3.38681717
29positive regulation of protein homodimerization activity (GO:0090073)3.37421833
30histone H2A acetylation (GO:0043968)3.36796519
31retinal cone cell development (GO:0046549)3.35040551
32detection of light stimulus involved in visual perception (GO:0050908)3.31123222
33detection of light stimulus involved in sensory perception (GO:0050962)3.31123222
34regulation of transmission of nerve impulse (GO:0051969)3.30138019
35positive regulation of transforming growth factor beta production (GO:0071636)3.28437512
36developmental pigmentation (GO:0048066)3.27196431
37protein-chromophore linkage (GO:0018298)3.26786827
38kynurenine metabolic process (GO:0070189)3.24291563
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21543917
40negative regulation of telomere maintenance (GO:0032205)3.21531170
41sperm capacitation (GO:0048240)3.17914592
42metallo-sulfur cluster assembly (GO:0031163)3.16056678
43iron-sulfur cluster assembly (GO:0016226)3.16056678
44gamma-aminobutyric acid transport (GO:0015812)3.15942962
45sulfation (GO:0051923)3.11645968
46membrane depolarization during action potential (GO:0086010)3.09637084
47cornea development in camera-type eye (GO:0061303)3.09268715
48transcription elongation from RNA polymerase III promoter (GO:0006385)2.99762244
49termination of RNA polymerase III transcription (GO:0006386)2.99762244
50glycerophospholipid catabolic process (GO:0046475)2.98151975
51dicarboxylic acid catabolic process (GO:0043649)2.94410475
52neuronal action potential (GO:0019228)2.93688940
53aspartate family amino acid catabolic process (GO:0009068)2.91557821
54tryptophan catabolic process (GO:0006569)2.90247953
55indole-containing compound catabolic process (GO:0042436)2.90247953
56indolalkylamine catabolic process (GO:0046218)2.90247953
57tachykinin receptor signaling pathway (GO:0007217)2.90010681
58negative regulation of mast cell activation (GO:0033004)2.88659533
59positive regulation of T-helper 1 type immune response (GO:0002827)2.88194758
60cilium or flagellum-dependent cell motility (GO:0001539)2.86345265
61indole-containing compound metabolic process (GO:0042430)2.80113516
62mitochondrial RNA metabolic process (GO:0000959)2.78228544
63transmission of nerve impulse (GO:0019226)2.76028381
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75817336
65photoreceptor cell development (GO:0042461)2.75378847
66C4-dicarboxylate transport (GO:0015740)2.74563368
67DNA methylation involved in gamete generation (GO:0043046)2.71939414
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71191075
69quinone biosynthetic process (GO:1901663)2.68837997
70transcription elongation from RNA polymerase I promoter (GO:0006362)2.66966857
71phasic smooth muscle contraction (GO:0014821)2.66393026
72regulation of male gonad development (GO:2000018)2.64943077
73resolution of meiotic recombination intermediates (GO:0000712)2.63413105
74sperm motility (GO:0030317)2.61146894
75pseudouridine synthesis (GO:0001522)2.59646363
76eye photoreceptor cell development (GO:0042462)2.59426833
77reproduction (GO:0000003)2.58170117
78regulation of T cell cytokine production (GO:0002724)2.56681783
79DNA demethylation (GO:0080111)2.56485946
80inositol metabolic process (GO:0006020)2.55554824
81termination of RNA polymerase I transcription (GO:0006363)2.55256558
82DNA catabolic process, exonucleolytic (GO:0000738)2.52907251
83protein K11-linked deubiquitination (GO:0035871)2.52803712
84DNA damage response, detection of DNA damage (GO:0042769)2.51009487
85sphingomyelin metabolic process (GO:0006684)2.48448461
86regulation of megakaryocyte differentiation (GO:0045652)2.46922702
87cullin deneddylation (GO:0010388)2.46204813
88protein localization to cilium (GO:0061512)2.46115853
89protein deneddylation (GO:0000338)2.45950466
90alkaloid metabolic process (GO:0009820)2.45419578
91calcium ion import (GO:0070509)2.45399305
92tryptophan metabolic process (GO:0006568)2.44352631
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44323207
94cilium organization (GO:0044782)2.43559309
95reflex (GO:0060004)2.42321683
96fatty acid elongation (GO:0030497)2.41281502
97postsynaptic membrane organization (GO:0001941)2.39127043
98signal peptide processing (GO:0006465)2.38851074
99cilium assembly (GO:0042384)2.37092878
100protein K6-linked ubiquitination (GO:0085020)2.36702775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.29550825
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.28709227
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.70692209
4VDR_22108803_ChIP-Seq_LS180_Human3.42275766
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18755585
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81147569
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.31394852
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18055345
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.13776330
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09174304
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07204138
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06717487
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06692885
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03648877
15EZH2_22144423_ChIP-Seq_EOC_Human1.97468981
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96996853
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95267310
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91292079
19GBX2_23144817_ChIP-Seq_PC3_Human1.88919797
20FUS_26573619_Chip-Seq_HEK293_Human1.88065665
21TAF15_26573619_Chip-Seq_HEK293_Human1.86484010
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86183229
23IGF1R_20145208_ChIP-Seq_DFB_Human1.83102592
24ER_23166858_ChIP-Seq_MCF-7_Human1.82895830
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81888867
26EWS_26573619_Chip-Seq_HEK293_Human1.76977715
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75317259
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69584379
29P300_19829295_ChIP-Seq_ESCs_Human1.67571056
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63829036
31CBP_20019798_ChIP-Seq_JUKART_Human1.63829036
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.61715068
33MYC_18940864_ChIP-ChIP_HL60_Human1.60517855
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59730920
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59239462
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54002106
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.50948192
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49811076
39BCAT_22108803_ChIP-Seq_LS180_Human1.48644785
40TCF4_22108803_ChIP-Seq_LS180_Human1.46629575
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.46237921
42AR_21572438_ChIP-Seq_LNCaP_Human1.45181259
43AR_25329375_ChIP-Seq_VCAP_Human1.45140887
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44966121
45IRF1_19129219_ChIP-ChIP_H3396_Human1.42599224
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42508868
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.42451168
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.42209769
49TP53_22573176_ChIP-Seq_HFKS_Human1.34696752
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34248008
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31834524
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.31549885
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30670107
54SMAD4_21799915_ChIP-Seq_A2780_Human1.29513604
55HTT_18923047_ChIP-ChIP_STHdh_Human1.28719078
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27733798
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.27609853
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26764765
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.24619553
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24178740
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22281946
62VDR_23849224_ChIP-Seq_CD4+_Human1.20820605
63TCF4_23295773_ChIP-Seq_U87_Human1.17037575
64STAT3_23295773_ChIP-Seq_U87_Human1.15124192
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15096433
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13943928
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.13513667
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13448679
69SOX2_19829295_ChIP-Seq_ESCs_Human1.12758293
70NANOG_19829295_ChIP-Seq_ESCs_Human1.12758293
71NCOR_22424771_ChIP-Seq_293T_Human1.11596967
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11352273
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09411590
74CIITA_25753668_ChIP-Seq_RAJI_Human1.08845599
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08756826
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.06740284
77P53_22387025_ChIP-Seq_ESCs_Mouse1.05676299
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04515433
79REST_21632747_ChIP-Seq_MESCs_Mouse1.03972331
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03784335
81FOXH1_21741376_ChIP-Seq_EPCs_Human1.03353913
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02183109
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.00663872
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00361383
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98923308
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.98306037
87SMAD3_21741376_ChIP-Seq_EPCs_Human0.97858719
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97389385
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97099134
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96734115
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96468548
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95663066
93RUNX2_22187159_ChIP-Seq_PCA_Human0.95144076
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.92889804
95OCT4_18555785_Chip-Seq_ESCs_Mouse0.92563444
96AR_20517297_ChIP-Seq_VCAP_Human0.91861761
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90481777
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.89862385
99CTCF_18555785_Chip-Seq_ESCs_Mouse0.89788909
100FOXP3_21729870_ChIP-Seq_TREG_Human0.89668414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.63091086
2MP0002102_abnormal_ear_morphology3.11121836
3MP0005551_abnormal_eye_electrophysiolog3.05694142
4MP0001764_abnormal_homeostasis2.95019003
5MP0001986_abnormal_taste_sensitivity2.80514348
6MP0001485_abnormal_pinna_reflex2.79639805
7MP0004147_increased_porphyrin_level2.71572981
8MP0005646_abnormal_pituitary_gland2.43210076
9MP0002736_abnormal_nociception_after2.37261708
10MP0005253_abnormal_eye_physiology2.36339537
11MP0008872_abnormal_physiological_respon2.33234110
12MP0001968_abnormal_touch/_nociception2.22669342
13MP0006292_abnormal_olfactory_placode2.20510231
14MP0001486_abnormal_startle_reflex2.18481865
15MP0009046_muscle_twitch2.14271715
16MP0009745_abnormal_behavioral_response1.96760264
17MP0002735_abnormal_chemical_nociception1.94780040
18MP0000015_abnormal_ear_pigmentation1.91045637
19MP0003646_muscle_fatigue1.89986129
20MP0004145_abnormal_muscle_electrophysio1.87847751
21MP0004142_abnormal_muscle_tone1.87819172
22MP0008875_abnormal_xenobiotic_pharmacok1.82293854
23MP0005645_abnormal_hypothalamus_physiol1.81674231
24MP0008877_abnormal_DNA_methylation1.75199925
25MP0000631_abnormal_neuroendocrine_gland1.60448237
26MP0001905_abnormal_dopamine_level1.59871123
27MP0006276_abnormal_autonomic_nervous1.59269990
28MP0005075_abnormal_melanosome_morpholog1.58874426
29MP0000372_irregular_coat_pigmentation1.58054576
30MP0002272_abnormal_nervous_system1.57156518
31MP0009379_abnormal_foot_pigmentation1.57151063
32MP0003880_abnormal_central_pattern1.55813458
33MP0006072_abnormal_retinal_apoptosis1.51665092
34MP0002064_seizures1.50913515
35MP0001501_abnormal_sleep_pattern1.49966990
36MP0004742_abnormal_vestibular_system1.46163333
37MP0001502_abnormal_circadian_rhythm1.45924670
38MP0003718_maternal_effect1.41496638
39MP0008789_abnormal_olfactory_epithelium1.35955467
40MP0005174_abnormal_tail_pigmentation1.35854275
41MP0002006_tumorigenesis1.34865450
42MP0005310_abnormal_salivary_gland1.32903699
43MP0008057_abnormal_DNA_replication1.29538344
44MP0003195_calcinosis1.29360355
45MP0002095_abnormal_skin_pigmentation1.27249106
46MP0005167_abnormal_blood-brain_barrier1.26269517
47MP0004782_abnormal_surfactant_physiolog1.23958128
48MP0003283_abnormal_digestive_organ1.23115123
49MP0004885_abnormal_endolymph1.22488048
50MP0002751_abnormal_autonomic_nervous1.18074320
51MP0002572_abnormal_emotion/affect_behav1.16959577
52MP0005386_behavior/neurological_phenoty1.14136512
53MP0004924_abnormal_behavior1.14136512
54MP0001963_abnormal_hearing_physiology1.14132555
55MP0003787_abnormal_imprinting1.12269344
56MP0008775_abnormal_heart_ventricle1.11522347
57MP0001188_hyperpigmentation1.09820155
58MP0002160_abnormal_reproductive_system1.09375756
59MP0002234_abnormal_pharynx_morphology1.08237271
60MP0002876_abnormal_thyroid_physiology1.07190777
61MP0004043_abnormal_pH_regulation1.05577529
62MP0005451_abnormal_body_composition1.05451770
63MP0002184_abnormal_innervation1.04685460
64MP0002752_abnormal_somatic_nervous1.04021582
65MP0003183_abnormal_peptide_metabolism1.03808136
66MP0005195_abnormal_posterior_eye1.03581591
67MP0006036_abnormal_mitochondrial_physio1.02160311
68MP0000427_abnormal_hair_cycle1.01411505
69MP0005499_abnormal_olfactory_system0.99628928
70MP0005394_taste/olfaction_phenotype0.99628928
71MP0002282_abnormal_trachea_morphology0.99158546
72MP0003635_abnormal_synaptic_transmissio0.97520037
73MP0008058_abnormal_DNA_repair0.97224632
74MP0004215_abnormal_myocardial_fiber0.96704465
75MP0003633_abnormal_nervous_system0.96556926
76MP0002067_abnormal_sensory_capabilities0.96382032
77MP0001970_abnormal_pain_threshold0.95217457
78MP0002229_neurodegeneration0.93196755
79MP0005389_reproductive_system_phenotype0.92286621
80MP0002733_abnormal_thermal_nociception0.91088315
81MP0002822_catalepsy0.90686546
82MP0004134_abnormal_chest_morphology0.90173779
83MP0005391_vision/eye_phenotype0.89340097
84MP0000569_abnormal_digit_pigmentation0.88890280
85MP0000026_abnormal_inner_ear0.86376007
86MP0002063_abnormal_learning/memory/cond0.84239637
87MP0000049_abnormal_middle_ear0.83385328
88MP0002653_abnormal_ependyma_morphology0.82833369
89MP0001661_extended_life_span0.82668142
90MP0001324_abnormal_eye_pigmentation0.78278906
91MP0001929_abnormal_gametogenesis0.76696136
92MP0002557_abnormal_social/conspecific_i0.76478647
93MP0003656_abnormal_erythrocyte_physiolo0.70360046
94MP0005376_homeostasis/metabolism_phenot0.69226751
95MP0004085_abnormal_heartbeat0.68504281
96MP0001664_abnormal_digestion0.67003423
97MP0005410_abnormal_fertilization0.66681186
98MP0000538_abnormal_urinary_bladder0.66510461
99MP0000613_abnormal_salivary_gland0.65708955
100MP0003938_abnormal_ear_development0.65481872

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.59786721
2Retinal dysplasia (HP:0007973)4.30356198
3Cerebellar dysplasia (HP:0007033)3.73804127
4Pancreatic fibrosis (HP:0100732)3.62422181
5Pancreatic cysts (HP:0001737)3.61009426
6Congenital stationary night blindness (HP:0007642)3.50808402
7Attenuation of retinal blood vessels (HP:0007843)3.26813010
8Gaze-evoked nystagmus (HP:0000640)3.23138382
9Optic nerve hypoplasia (HP:0000609)3.23048264
10Abnormality of midbrain morphology (HP:0002418)3.22642002
11Molar tooth sign on MRI (HP:0002419)3.22642002
12True hermaphroditism (HP:0010459)3.18848647
13Chronic mucocutaneous candidiasis (HP:0002728)3.14826996
14Recurrent cutaneous fungal infections (HP:0011370)3.14826996
15Optic neuritis (HP:0100653)3.03394929
16Retrobulbar optic neuritis (HP:0100654)3.03394929
17Abnormality of the labia minora (HP:0012880)3.00234069
18Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.81424892
19Acute necrotizing encephalopathy (HP:0006965)2.79383717
20Nephronophthisis (HP:0000090)2.77128244
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76812075
22Abnormality of lateral ventricle (HP:0030047)2.73880493
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.72191766
24Abnormality of B cell number (HP:0010975)2.70848720
25Medial flaring of the eyebrow (HP:0010747)2.69856854
26B lymphocytopenia (HP:0010976)2.67633654
27Abnormal rod and cone electroretinograms (HP:0008323)2.62358248
28Mitochondrial inheritance (HP:0001427)2.60134646
29Progressive macrocephaly (HP:0004481)2.58207607
30Orchitis (HP:0100796)2.54505185
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.53495845
32Increased hepatocellular lipid droplets (HP:0006565)2.51491900
33Bilateral sensorineural hearing impairment (HP:0008619)2.48621872
34Panhypogammaglobulinemia (HP:0003139)2.46348318
35Acute encephalopathy (HP:0006846)2.44123393
36Lissencephaly (HP:0001339)2.37482455
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.36659444
38Sclerocornea (HP:0000647)2.36639040
39Keratoconus (HP:0000563)2.34857988
40Increased corneal curvature (HP:0100692)2.34857988
41Increased CSF lactate (HP:0002490)2.32338513
42Chronic hepatic failure (HP:0100626)2.32170299
43Short tibia (HP:0005736)2.30024670
44Abnormal mitochondria in muscle tissue (HP:0008316)2.29889701
45Abnormality of the renal medulla (HP:0100957)2.26566105
46Lipid accumulation in hepatocytes (HP:0006561)2.25160942
47Optic disc pallor (HP:0000543)2.24344627
48Abnormality of the renal cortex (HP:0011035)2.23476681
49Thyroiditis (HP:0100646)2.21234245
50Myositis (HP:0100614)2.19695337
51Pachygyria (HP:0001302)2.18853448
52Cystic liver disease (HP:0006706)2.18673747
53Amblyopia (HP:0000646)2.18531446
54Septo-optic dysplasia (HP:0100842)2.17059687
55Type I transferrin isoform profile (HP:0003642)2.11687090
56Renal Fanconi syndrome (HP:0001994)2.08012017
57Tubular atrophy (HP:0000092)2.07529345
58Broad-based gait (HP:0002136)2.07373438
59Abnormal hair whorl (HP:0010721)2.06875318
60Pheochromocytoma (HP:0002666)2.05423294
61Keratoconjunctivitis (HP:0001096)2.04931439
62Genital tract atresia (HP:0001827)2.04620145
63Methylmalonic acidemia (HP:0002912)2.04096493
64Gait imbalance (HP:0002141)2.03434486
65Hypoproteinemia (HP:0003075)2.02989132
66Generalized tonic-clonic seizures (HP:0002069)2.02046846
67Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.01228625
68Hemiparesis (HP:0001269)1.99245502
69Chorioretinal atrophy (HP:0000533)1.98648651
70Keratoconjunctivitis sicca (HP:0001097)1.96829151
71Congenital primary aphakia (HP:0007707)1.96731202
72Pigmentary retinal degeneration (HP:0001146)1.96713446
73Increased serum lactate (HP:0002151)1.94605235
74Hemoptysis (HP:0002105)1.92531189
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.89811916
76Abnormality of the proximal phalanges of the hand (HP:0009834)1.89651111
77Constricted visual fields (HP:0001133)1.88239509
78Focal seizures (HP:0007359)1.86819336
79Epileptic encephalopathy (HP:0200134)1.86351256
80Abnormal protein glycosylation (HP:0012346)1.85873683
81Abnormal glycosylation (HP:0012345)1.85873683
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85873683
83Abnormal protein N-linked glycosylation (HP:0012347)1.85873683
84Central scotoma (HP:0000603)1.83291960
85Postaxial hand polydactyly (HP:0001162)1.83125194
86Nephrogenic diabetes insipidus (HP:0009806)1.83053436
87CNS hypomyelination (HP:0003429)1.82143178
88Inability to walk (HP:0002540)1.81016135
89Hyperlipoproteinemia (HP:0010980)1.80305741
90Abnormality of the vitreous humor (HP:0004327)1.79102748
91Severe combined immunodeficiency (HP:0004430)1.78785904
92Supernumerary spleens (HP:0009799)1.77429925
93Encephalitis (HP:0002383)1.74997411
943-Methylglutaconic aciduria (HP:0003535)1.74748376
95Neuroendocrine neoplasm (HP:0100634)1.73149127
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72514042
97Atonic seizures (HP:0010819)1.71446856
98Decreased central vision (HP:0007663)1.70995646
99Anencephaly (HP:0002323)1.68595836
100Progressive inability to walk (HP:0002505)1.67283873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.86249551
2MAP4K23.83713815
3NEK92.59607262
4TEC2.58505446
5NEK12.54735896
6MAP2K72.33478424
7CASK2.30862347
8MAPK132.16494709
9WNK32.02421686
10STK162.02209328
11ADRBK21.91588219
12PKN11.85091131
13MAP3K41.84786116
14ZAK1.71360323
15SIK21.68068010
16STK391.59449892
17GRK11.59246675
18OXSR11.57056553
19NUAK11.55267932
20ERBB41.47842351
21SIK31.40054587
22TXK1.37811916
23ITK1.35394227
24NTRK31.34010116
25DYRK31.31071175
26MARK31.30463791
27BRSK21.22497306
28BCKDK1.17325876
29BMPR1B1.17311864
30PAK31.15956726
31WNK41.14863867
32DYRK21.10413136
33MARK11.10283893
34PBK1.08002831
35EPHA41.06939514
36TLK11.05790007
37SRPK10.99749021
38VRK20.95617746
39PTK2B0.93562859
40RPS6KA40.93499419
41RAF10.92587024
42PASK0.90403573
43INSRR0.90137639
44ATR0.88729828
45TNIK0.83329715
46TNK20.83269850
47BTK0.82438225
48CAMK2D0.82348090
49KSR10.81561965
50RPS6KA50.81379737
51WEE10.80413124
52EIF2AK30.79181328
53PRKCE0.78596981
54MAP3K70.76719721
55PRKCI0.75787572
56ERBB20.74715701
57JAK30.71672619
58DYRK1A0.66941500
59CSNK1G30.65181949
60CDK190.65105786
61IRAK10.64188111
62PRKCQ0.63498205
63PLK30.63310899
64MAP3K110.62950338
65CDK30.61822018
66CAMK2G0.61025502
67ADRBK10.59557134
68CDK80.58999453
69PIM20.58864665
70CSNK1G20.58703221
71CHEK20.58500907
72PINK10.58299900
73DYRK1B0.58055593
74PRKCG0.57494304
75ERBB30.55894671
76CSNK1G10.53964363
77CAMK40.53871824
78PIK3CG0.53332729
79PRKCZ0.51884195
80TIE10.49328551
81PRKACA0.49213583
82SGK20.47633768
83CAMK2A0.47307324
84CSNK1A1L0.47267479
85PIK3CA0.45653175
86STK38L0.45397425
87NME10.43680013
88GSK3A0.43488515
89CAMK10.43436400
90CAMK2B0.42518613
91NLK0.42030891
92MAP2K40.40903353
93PRKAA10.40442039
94PLK10.39484870
95TAOK30.38460364
96PRKCA0.38385732
97MST40.37727750
98PAK60.36656788
99VRK10.34961053
100GRK60.33840794

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.51609891
2RNA polymerase_Homo sapiens_hsa030202.98284576
3Basal transcription factors_Homo sapiens_hsa030222.74526483
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63305973
5Oxidative phosphorylation_Homo sapiens_hsa001902.58524456
6Ether lipid metabolism_Homo sapiens_hsa005652.50164173
7Linoleic acid metabolism_Homo sapiens_hsa005912.39574279
8Butanoate metabolism_Homo sapiens_hsa006502.35858791
9Parkinsons disease_Homo sapiens_hsa050122.22114310
10Protein export_Homo sapiens_hsa030602.10002427
11Primary immunodeficiency_Homo sapiens_hsa053402.08520197
12Proteasome_Homo sapiens_hsa030501.98720322
13Nitrogen metabolism_Homo sapiens_hsa009101.90529023
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86435636
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86282473
16Huntingtons disease_Homo sapiens_hsa050161.79741599
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79239590
18Nicotine addiction_Homo sapiens_hsa050331.77018621
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76618731
20Fanconi anemia pathway_Homo sapiens_hsa034601.71993860
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71399686
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68927589
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66339111
24Fatty acid elongation_Homo sapiens_hsa000621.65148117
25Tryptophan metabolism_Homo sapiens_hsa003801.54666425
26Taste transduction_Homo sapiens_hsa047421.49172836
27Homologous recombination_Homo sapiens_hsa034401.49156856
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.44363722
29Alzheimers disease_Homo sapiens_hsa050101.37766435
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26397736
31Morphine addiction_Homo sapiens_hsa050321.23968376
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.23423332
33* Olfactory transduction_Homo sapiens_hsa047401.22352577
34Circadian entrainment_Homo sapiens_hsa047131.21145362
35Cardiac muscle contraction_Homo sapiens_hsa042601.16795648
36GABAergic synapse_Homo sapiens_hsa047271.16348747
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15942892
38Peroxisome_Homo sapiens_hsa041461.13926056
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13550864
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.13027810
41Pyrimidine metabolism_Homo sapiens_hsa002401.08821857
42RNA degradation_Homo sapiens_hsa030181.08672913
43Glutamatergic synapse_Homo sapiens_hsa047241.07932751
44One carbon pool by folate_Homo sapiens_hsa006701.06597722
45Caffeine metabolism_Homo sapiens_hsa002321.03938528
46Purine metabolism_Homo sapiens_hsa002300.98536799
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98173555
48Circadian rhythm_Homo sapiens_hsa047100.97588503
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91196438
50Serotonergic synapse_Homo sapiens_hsa047260.89279156
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89160308
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88655549
53Renin-angiotensin system_Homo sapiens_hsa046140.84505758
54Regulation of autophagy_Homo sapiens_hsa041400.83283974
55Ovarian steroidogenesis_Homo sapiens_hsa049130.82934923
56Retinol metabolism_Homo sapiens_hsa008300.79615536
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79190318
58Selenocompound metabolism_Homo sapiens_hsa004500.77325126
59Fatty acid metabolism_Homo sapiens_hsa012120.73202922
60Metabolic pathways_Homo sapiens_hsa011000.72686337
61Chemical carcinogenesis_Homo sapiens_hsa052040.71750500
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71142785
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70670859
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67933016
65Arachidonic acid metabolism_Homo sapiens_hsa005900.63973603
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62667485
67Fat digestion and absorption_Homo sapiens_hsa049750.61414217
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.61265548
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61060323
70Ribosome_Homo sapiens_hsa030100.60580597
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59955408
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59549165
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59161512
74Calcium signaling pathway_Homo sapiens_hsa040200.55537327
75Hedgehog signaling pathway_Homo sapiens_hsa043400.53416589
76ABC transporters_Homo sapiens_hsa020100.52895868
77Propanoate metabolism_Homo sapiens_hsa006400.52709952
78Dopaminergic synapse_Homo sapiens_hsa047280.51513208
79Sulfur metabolism_Homo sapiens_hsa009200.50716648
80Dorso-ventral axis formation_Homo sapiens_hsa043200.47819763
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45882914
82Vitamin digestion and absorption_Homo sapiens_hsa049770.44520021
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42490443
84Sphingolipid metabolism_Homo sapiens_hsa006000.40591481
85Salivary secretion_Homo sapiens_hsa049700.40589782
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.39974185
87Non-homologous end-joining_Homo sapiens_hsa034500.39197641
88Basal cell carcinoma_Homo sapiens_hsa052170.39175889
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38186464
90Insulin secretion_Homo sapiens_hsa049110.37529007
91Glycerolipid metabolism_Homo sapiens_hsa005610.35214309
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34760050
93Oocyte meiosis_Homo sapiens_hsa041140.34344252
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.33151041
95Cholinergic synapse_Homo sapiens_hsa047250.32861721
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31439225
97N-Glycan biosynthesis_Homo sapiens_hsa005100.30114874
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29638887
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29526790
100Collecting duct acid secretion_Homo sapiens_hsa049660.29038659

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