OR52K3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.16437143
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.16437143
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.16437143
4modulation by symbiont of host immune response (GO:0052553)6.16437143
5positive regulation by symbiont of host defense response (GO:0052509)6.16437143
6modulation by symbiont of host defense response (GO:0052031)6.16437143
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.00826885
8negative regulation of cell killing (GO:0031342)5.51516319
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.51516319
10macrophage activation involved in immune response (GO:0002281)5.36354518
11positive regulation of gamma-delta T cell activation (GO:0046645)5.34825095
12neutrophil activation involved in immune response (GO:0002283)5.15289061
13detection of molecule of bacterial origin (GO:0032490)5.10669117
14detection of other organism (GO:0098543)4.96112809
15response to peptidoglycan (GO:0032494)4.87970903
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.81975929
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79209120
18cellular extravasation (GO:0045123)4.72279898
19antigen processing and presentation of endogenous antigen (GO:0019883)4.68500287
20phospholipid efflux (GO:0033700)4.63348565
21detection of external biotic stimulus (GO:0098581)4.55428980
22detection of bacterium (GO:0016045)4.54832475
23regulation of interferon-beta biosynthetic process (GO:0045357)4.38256224
24leukocyte migration involved in inflammatory response (GO:0002523)4.35077704
25regulation of triglyceride catabolic process (GO:0010896)4.32557578
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30303028
27negative regulation of interleukin-12 production (GO:0032695)4.29107740
28regulation of B cell receptor signaling pathway (GO:0050855)4.26410298
29response to host immune response (GO:0052572)4.20761070
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.20761070
31microglial cell activation (GO:0001774)4.16409192
32neutrophil activation (GO:0042119)4.14056592
33detection of biotic stimulus (GO:0009595)4.01358965
34macrophage activation (GO:0042116)3.95203707
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.93880605
36response to host (GO:0075136)3.88928489
37response to host defenses (GO:0052200)3.88928489
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.88928489
39regulation of gamma-delta T cell activation (GO:0046643)3.87910103
40leukocyte aggregation (GO:0070486)3.84151530
41respiratory burst (GO:0045730)3.82123428
42neutrophil mediated immunity (GO:0002446)3.78350341
43granulocyte activation (GO:0036230)3.75825659
44myeloid cell activation involved in immune response (GO:0002275)3.74499796
45response to interleukin-15 (GO:0070672)3.62182091
46positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.56157225
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54614083
48type I interferon signaling pathway (GO:0060337)3.54484849
49cellular response to type I interferon (GO:0071357)3.54484849
50immunoglobulin mediated immune response (GO:0016064)3.53967114
51response to type I interferon (GO:0034340)3.51790787
52plasma lipoprotein particle assembly (GO:0034377)3.50321886
53high-density lipoprotein particle remodeling (GO:0034375)3.47312275
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43274426
55production of molecular mediator involved in inflammatory response (GO:0002532)3.43088055
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.41539094
57regulation of mast cell degranulation (GO:0043304)3.38314906
58negative regulation of leukocyte mediated immunity (GO:0002704)3.35451845
59cellular response to interleukin-15 (GO:0071350)3.35249578
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.27953802
61regulation of gamma-delta T cell differentiation (GO:0045586)3.25511380
62antigen processing and presentation via MHC class Ib (GO:0002475)3.25242421
63negative regulation of T cell mediated immunity (GO:0002710)3.21921320
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21481090
65negative regulation of cytokine production involved in immune response (GO:0002719)3.21054088
66myeloid leukocyte mediated immunity (GO:0002444)3.18406398
67germinal center formation (GO:0002467)3.17319979
68positive regulation of mast cell activation (GO:0033005)3.15478733
69regulation of mast cell activation involved in immune response (GO:0033006)3.15451705
70regulation of T-helper 2 cell differentiation (GO:0045628)3.12389504
71protein-lipid complex assembly (GO:0065005)3.11978063
72regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11974333
73response to muramyl dipeptide (GO:0032495)3.10803615
74positive regulation of interferon-alpha production (GO:0032727)3.09332494
75lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04500920
76regulation of mast cell activation (GO:0033003)3.02530666
77leukocyte degranulation (GO:0043299)3.02187361
78defense response to protozoan (GO:0042832)2.97945356
79neutrophil chemotaxis (GO:0030593)2.97524164
80positive regulation of cellular amide metabolic process (GO:0034250)2.95693919
81interferon-gamma-mediated signaling pathway (GO:0060333)2.95680433
82regulation of leukocyte degranulation (GO:0043300)2.94437045
83reverse cholesterol transport (GO:0043691)2.93919887
84response to interferon-alpha (GO:0035455)2.93430849
85regulation of interferon-alpha production (GO:0032647)2.92791221
86B cell receptor signaling pathway (GO:0050853)2.91733036
87neutrophil migration (GO:1990266)2.89679593
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88705298
89regulation of interleukin-8 biosynthetic process (GO:0045414)2.88233737
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87887687
91negative regulation of T-helper cell differentiation (GO:0045623)2.87887687
92regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87478397
93positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86786369
94I-kappaB phosphorylation (GO:0007252)2.86438986
95negative regulation of interleukin-1 production (GO:0032692)2.86005874
96regulation of T cell tolerance induction (GO:0002664)2.84373092
97regulation of tolerance induction (GO:0002643)2.84233325
98dendritic cell migration (GO:0036336)2.78841283
99dendritic cell chemotaxis (GO:0002407)2.78051908
100myeloid leukocyte activation (GO:0002274)2.75625958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.60934493
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.24557317
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.16282341
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65381098
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44085610
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.36287128
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.26714633
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.21460021
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17138233
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80966848
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67690682
12RUNX_20019798_ChIP-Seq_JUKART_Human2.65692036
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65534325
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62917360
15SPI1_23127762_ChIP-Seq_K562_Human2.57250123
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46765824
17GATA1_22025678_ChIP-Seq_K562_Human2.45499446
18VDR_24763502_ChIP-Seq_THP-1_Human2.42392733
19SPI1_23547873_ChIP-Seq_NB4_Human2.40758164
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37370569
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.34560818
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23811862
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18065298
24SCL_19346495_ChIP-Seq_HPC-7_Human2.16158660
25VDR_21846776_ChIP-Seq_THP-1_Human2.13324831
26MYB_26560356_Chip-Seq_TH2_Human2.10907549
27VDR_24787735_ChIP-Seq_THP-1_Human2.03452392
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03341852
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01527134
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97611749
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97455286
32MAF_26560356_Chip-Seq_TH1_Human1.91591758
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89058325
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.86513694
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82194024
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81412910
37MYB_26560356_Chip-Seq_TH1_Human1.72439198
38UTX_26944678_Chip-Seq_JUKART_Human1.71407384
39GATA3_27048872_Chip-Seq_THYMUS_Human1.64095585
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63335880
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61299888
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58454522
43TCF7_22412390_ChIP-Seq_EML_Mouse1.52491985
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52442132
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.52234385
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48452074
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48418038
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47798175
49MAF_26560356_Chip-Seq_TH2_Human1.39721646
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39040441
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38980414
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.37639853
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.37272623
54GATA3_26560356_Chip-Seq_TH2_Human1.34806650
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32724469
56KDM2B_26808549_Chip-Seq_DND41_Human1.32547261
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31988414
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31685303
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29445347
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18562335
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17968379
62PU_27001747_Chip-Seq_BMDM_Mouse1.14992802
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13327424
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12703166
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12389602
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11977903
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11906387
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11804603
69MYC_22102868_ChIP-Seq_BL_Human1.11742768
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10965265
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07441437
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06392330
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03635797
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03560667
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00235629
76SMRT_27268052_Chip-Seq_Bcells_Human1.00175860
77GATA1_19941826_ChIP-Seq_K562_Human0.97855241
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92947150
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91200819
80GATA2_19941826_ChIP-Seq_K562_Human0.88690687
81ELK3_25401928_ChIP-Seq_HUVEC_Human0.87569769
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87540425
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87168416
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87072384
85GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86905840
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86676736
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.86158692
88LXR_22158963_ChIP-Seq_LIVER_Mouse0.83245551
89ESR1_20079471_ChIP-ChIP_T-47D_Human0.82744723
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81073883
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81005004
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78353246
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77225436
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76881135
95BCL6_27268052_Chip-Seq_Bcells_Human0.75989799
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75767864
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75282941
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.74407786
99LXR_22292898_ChIP-Seq_THP-1_Human0.73991531
100EGR1_19032775_ChIP-ChIP_M12_Human0.73794234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.43433467
2MP0009840_abnormal_foam_cell4.29338860
3MP0003436_decreased_susceptibility_to4.09020222
4MP0003303_peritoneal_inflammation3.80007981
5MP0001835_abnormal_antigen_presentation3.52360688
6MP0002419_abnormal_innate_immunity3.10359364
7MP0003191_abnormal_cellular_cholesterol2.79905539
8MP0006082_CNS_inflammation2.76822428
9MP0005025_abnormal_response_to2.69390858
10MP0009785_altered_susceptibility_to2.67055336
11MP0001800_abnormal_humoral_immune2.58764392
12MP0005000_abnormal_immune_tolerance2.49949174
13MP0005387_immune_system_phenotype2.47584244
14MP0001790_abnormal_immune_system2.47584244
15MP0000685_abnormal_immune_system2.42117795
16MP0002723_abnormal_immune_serum2.37102990
17MP0005671_abnormal_response_to2.29223171
18MP0002452_abnormal_antigen_presenting2.23046958
19MP0003300_gastrointestinal_ulcer2.19823365
20MP0002420_abnormal_adaptive_immunity2.19540393
21MP0001533_abnormal_skeleton_physiology2.18109445
22MP0001819_abnormal_immune_cell2.17502083
23MP0002148_abnormal_hypersensitivity_rea2.01014891
24MP0003045_fibrosis1.96287637
25MP0005464_abnormal_platelet_physiology1.90776664
26MP0003828_pulmonary_edema1.86385613
27MP0002132_abnormal_respiratory_system1.78814024
28MP0008260_abnormal_autophagy1.78020988
29MP0010155_abnormal_intestine_physiology1.77837334
30MP0002405_respiratory_system_inflammati1.72692674
31MP0000716_abnormal_immune_system1.64487184
32MP0004883_abnormal_blood_vessel1.63152636
33MP0001845_abnormal_inflammatory_respons1.61000081
34MP0009278_abnormal_bone_marrow1.59035986
35MP0005164_abnormal_response_to1.57987352
36MP0005360_urolithiasis1.57101135
37MP0003690_abnormal_glial_cell1.54412973
38MP0009764_decreased_sensitivity_to1.51611773
39MP0008469_abnormal_protein_level1.50894943
40MP0002398_abnormal_bone_marrow1.50750983
41MP0005451_abnormal_body_composition1.46579548
42MP0005377_hearing/vestibular/ear_phenot1.46405402
43MP0003878_abnormal_ear_physiology1.46405402
44MP0003866_abnormal_defecation1.45044174
45MP0003183_abnormal_peptide_metabolism1.43865711
46MP0003172_abnormal_lysosome_physiology1.42199992
47MP0003763_abnormal_thymus_physiology1.38334784
48MP0004510_myositis1.36352142
49MP0002277_abnormal_respiratory_mucosa1.35350085
50MP0004947_skin_inflammation1.33574334
51MP0003950_abnormal_plasma_membrane1.33139852
52MP0000465_gastrointestinal_hemorrhage1.29815903
53MP0004381_abnormal_hair_follicle1.27706870
54MP0004145_abnormal_muscle_electrophysio1.27547812
55MP0001851_eye_inflammation1.26781002
56MP0000689_abnormal_spleen_morphology1.25640487
57MP0002429_abnormal_blood_cell1.24281575
58MP0002722_abnormal_immune_system1.23943255
59MP0005397_hematopoietic_system_phenotyp1.22015441
60MP0001545_abnormal_hematopoietic_system1.22015441
61MP0003075_altered_response_to1.20170506
62MP0002998_abnormal_bone_remodeling1.19872223
63MP0002396_abnormal_hematopoietic_system1.17359032
64MP0005310_abnormal_salivary_gland1.15850850
65MP0002254_reproductive_system_inflammat1.15258017
66MP0005058_abnormal_lysosome_morphology1.13346859
67MP0000858_altered_metastatic_potential1.09837569
68MP0008004_abnormal_stomach_pH1.08460805
69MP0009333_abnormal_splenocyte_physiolog1.07447667
70MP0005166_decreased_susceptibility_to0.98725667
71MP0001958_emphysema0.97879536
72MP0000343_altered_response_to0.95588243
73MP0000604_amyloidosis0.94318127
74MP0001663_abnormal_digestive_system0.92891929
75MP0000703_abnormal_thymus_morphology0.90303960
76MP0000249_abnormal_blood_vessel0.85949874
77MP0005381_digestive/alimentary_phenotyp0.82545532
78MP0002168_other_aberrant_phenotype0.81650328
79MP0005390_skeleton_phenotype0.80489567
80MP0009763_increased_sensitivity_to0.72812930
81MP0002166_altered_tumor_susceptibility0.72259937
82MP0008874_decreased_physiological_sensi0.70272486
83MP0003656_abnormal_erythrocyte_physiolo0.69603225
84MP0005409_darkened_coat_color0.65662538
85MP0000015_abnormal_ear_pigmentation0.65428652
86MP0003448_altered_tumor_morphology0.65057726
87MP0000920_abnormal_myelination0.64787474
88MP0000569_abnormal_digit_pigmentation0.63746771
89MP0005319_abnormal_enzyme/_coenzyme0.61657589
90MP0000767_abnormal_smooth_muscle0.60180445
91MP0004484_altered_response_of0.60133173
92MP0001986_abnormal_taste_sensitivity0.59439917
93MP0002133_abnormal_respiratory_system0.57121673
94MP0005388_respiratory_system_phenotype0.57121673
95MP0010329_abnormal_lipoprotein_level0.57048501
96MP0004130_abnormal_muscle_cell0.55373734
97MP0005174_abnormal_tail_pigmentation0.55368780
98MP0004808_abnormal_hematopoietic_stem0.54947036
99MP0003795_abnormal_bone_structure0.54829637
100MP0002332_abnormal_exercise_endurance0.54056078

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)6.28955951
2Eczematoid dermatitis (HP:0000976)6.28553792
3Recurrent abscess formation (HP:0002722)5.74469656
4Myositis (HP:0100614)5.72418831
5Orchitis (HP:0100796)5.67467280
6Recurrent bacterial skin infections (HP:0005406)5.61001713
7Malnutrition (HP:0004395)5.46494264
8Retrobulbar optic neuritis (HP:0100654)5.37952285
9Optic neuritis (HP:0100653)5.37952285
10Recurrent gram-negative bacterial infections (HP:0005420)4.89637918
11Stomatitis (HP:0010280)4.51165644
12Elevated erythrocyte sedimentation rate (HP:0003565)4.17297083
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.14917458
14Recurrent fungal infections (HP:0002841)4.07819940
15Chronic mucocutaneous candidiasis (HP:0002728)3.96737914
16Recurrent cutaneous fungal infections (HP:0011370)3.96737914
17Mediastinal lymphadenopathy (HP:0100721)3.91951740
18Gastrointestinal infarctions (HP:0005244)3.87098298
19Recurrent skin infections (HP:0001581)3.86993620
20Keratoconjunctivitis sicca (HP:0001097)3.80053425
21Hypochromic microcytic anemia (HP:0004840)3.78770777
22Gingival bleeding (HP:0000225)3.68865861
23Spontaneous hematomas (HP:0007420)3.66762833
24Chronic obstructive pulmonary disease (HP:0006510)3.61233031
25Obstructive lung disease (HP:0006536)3.61233031
26Meningitis (HP:0001287)3.53535666
27Keratoconjunctivitis (HP:0001096)3.51408416
28Amyloidosis (HP:0011034)3.48504186
29Encephalitis (HP:0002383)3.48413405
30Gingivitis (HP:0000230)3.42717588
31Increased IgE level (HP:0003212)3.26147256
32Hypobetalipoproteinemia (HP:0003563)3.24487306
33Vasculitis (HP:0002633)3.14732917
34Peritonitis (HP:0002586)3.13741237
35Urticaria (HP:0001025)3.10670465
36Episodic fever (HP:0001954)3.09908932
37Hyperlipoproteinemia (HP:0010980)3.09062740
38Hypochromic anemia (HP:0001931)2.97128962
39Prolonged bleeding time (HP:0003010)2.92870709
40Hemoptysis (HP:0002105)2.90714674
41Chest pain (HP:0100749)2.87584245
42Epistaxis (HP:0000421)2.86815450
43Arterial thrombosis (HP:0004420)2.81327898
44Pulmonary infiltrates (HP:0002113)2.80298136
45T lymphocytopenia (HP:0005403)2.77513178
46Abnormality of T cell number (HP:0011839)2.68060309
47Pulmonary embolism (HP:0002204)2.62539287
48Anorexia (HP:0002039)2.60109219
49Recurrent viral infections (HP:0004429)2.59271134
50Cellulitis (HP:0100658)2.57712982
51Leukocytosis (HP:0001974)2.44032319
52Inflammation of the large intestine (HP:0002037)2.40314638
53Sepsis (HP:0100806)2.39780218
54Petechiae (HP:0000967)2.37657391
55Increased serum ferritin (HP:0003281)2.35760817
56Abnormal platelet volume (HP:0011876)2.30283798
57Osteomyelitis (HP:0002754)2.28431265
58Loss of speech (HP:0002371)2.27132384
59Aortic aneurysm (HP:0004942)2.25413848
60Gangrene (HP:0100758)2.25158243
61Gastrointestinal inflammation (HP:0004386)2.24655365
62Abnormality of the peritoneum (HP:0002585)2.24377616
63Abnormality of pyrimidine metabolism (HP:0004353)2.22229519
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20904998
65Abnormality of T cells (HP:0002843)2.20187425
66Microcytic anemia (HP:0001935)2.19515479
67Segmental peripheral demyelination/remyelination (HP:0003481)2.17153819
68Abnormality of iron homeostasis (HP:0011031)2.16839857
69Joint hemorrhage (HP:0005261)2.15852849
70Abnormality of the pleura (HP:0002103)2.10083627
71Panhypogammaglobulinemia (HP:0003139)2.09581659
72Increased IgM level (HP:0003496)2.04253501
73Cheilitis (HP:0100825)2.02608068
74Abnormality of T cell physiology (HP:0011840)2.02130551
75Abnormality of the common coagulation pathway (HP:0010990)2.00835828
76Abnormality of the pericardium (HP:0001697)2.00245296
77Vertigo (HP:0002321)1.98700559
78Chronic otitis media (HP:0000389)1.95968649
79Abnormality of the endocardium (HP:0004306)1.95854379
80Keratitis (HP:0000491)1.95204262
81Colitis (HP:0002583)1.93387229
82Neoplasm of the heart (HP:0100544)1.93277642
83Vacuolated lymphocytes (HP:0001922)1.93207858
84Pustule (HP:0200039)1.92281664
85Gastrointestinal dysmotility (HP:0002579)1.91622452
86Granulocytopenia (HP:0001913)1.91520441
87Polyneuropathy (HP:0001271)1.90824866
88Acne (HP:0001061)1.87927262
89Thrombophlebitis (HP:0004418)1.87322511
90Dysostosis multiplex (HP:0000943)1.85990416
91Glomerulopathy (HP:0100820)1.85958131
92Tetany (HP:0001281)1.85007476
93Menorrhagia (HP:0000132)1.84740947
94Slow saccadic eye movements (HP:0000514)1.84604098
95Hypergammaglobulinemia (HP:0010702)1.83869914
96Abnormality of transition element cation homeostasis (HP:0011030)1.83095272
97Increased cerebral lipofuscin (HP:0011813)1.82064863
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80495965
99Joint swelling (HP:0001386)1.80207666
100Hepatosplenomegaly (HP:0001433)1.77997530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.55615541
2PIK3CG4.07739512
3IRAK43.25041333
4BLK3.03079868
5TYK22.84453117
6MAP2K32.80401350
7MAP4K12.64385828
8CSK2.53721608
9MUSK2.53457716
10DMPK2.48749681
11ERN12.42585942
12EPHB12.31449500
13TNK22.15906580
14TESK22.01000508
15FES1.94406046
16GRK61.91558259
17ZAP701.84776240
18TTN1.77071283
19PRPF4B1.60912132
20FGR1.57886989
21MAP3K31.56487185
22HCK1.54019061
23JAK31.52917173
24TAOK11.52777582
25TXK1.52595249
26JAK11.44978128
27BTK1.39894989
28JAK21.37894088
29SYK1.36823173
30IKBKE1.35202455
31KSR21.30534184
32MAP3K141.30278628
33IRAK21.26595650
34YES11.22658482
35IRAK11.18835916
36MYLK1.17948130
37TBK11.15516574
38LYN1.13904821
39MAP3K111.13340750
40CDC42BPA1.11190846
41MAP3K131.10243103
42MARK31.08951576
43MAP3K11.04784232
44CSF1R1.03187677
45LCK1.03049875
46MATK0.95531401
47KIT0.94731789
48MAP3K20.93235484
49NLK0.90910986
50PDK10.85700844
51MARK20.82628662
52SIK30.81568508
53PDPK10.81510755
54MAP3K70.80163036
55PTK2B0.77808251
56MAP3K60.77624923
57CDK190.77057391
58PTK60.76669950
59FGFR30.74878536
60STK100.74804279
61TAOK30.74443835
62TAOK20.74275273
63FGFR40.72603224
64LRRK20.71564374
65FYN0.68015774
66EPHA30.66967358
67RAF10.66712684
68ITK0.66256169
69ACVR1B0.65513630
70TEC0.64883365
71BMPR20.64582172
72PRKD20.62849130
73IKBKB0.58006262
74STK380.57622034
75WNK10.56353275
76MAPK70.55727015
77MAPK120.55205404
78MAP2K40.55123814
79STK110.53781560
80TGFBR20.50744072
81NEK90.46476017
82SGK30.45758915
83MAP2K60.42901596
84TRIB30.42335545
85MAP3K50.42243462
86RET0.41476151
87MAPKAPK20.38597142
88GRK70.38572267
89HIPK20.38376236
90RPS6KL10.37949530
91RPS6KC10.37949530
92SIK20.36882131
93PRKCQ0.36770982
94RPS6KA60.34614781
95PRKCZ0.33886521
96SGK20.32652435
97KSR10.30591982
98PRKAA20.25522060
99FRK0.24609167
100PRKD10.24546651

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.97570593
2Leishmaniasis_Homo sapiens_hsa051402.95565755
3Staphylococcus aureus infection_Homo sapiens_hsa051502.88947363
4Tuberculosis_Homo sapiens_hsa051522.14349456
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07576708
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06346723
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05181168
8B cell receptor signaling pathway_Homo sapiens_hsa046622.02677614
9Malaria_Homo sapiens_hsa051441.96698839
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95468598
11Graft-versus-host disease_Homo sapiens_hsa053321.91320172
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89572443
13Allograft rejection_Homo sapiens_hsa053301.84007032
14African trypanosomiasis_Homo sapiens_hsa051431.72889828
15Measles_Homo sapiens_hsa051621.71242305
16Autoimmune thyroid disease_Homo sapiens_hsa053201.67652219
17Chemokine signaling pathway_Homo sapiens_hsa040621.63950076
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63641917
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54237033
20Primary immunodeficiency_Homo sapiens_hsa053401.53940868
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.53098482
22Acute myeloid leukemia_Homo sapiens_hsa052211.51228504
23Influenza A_Homo sapiens_hsa051641.50033913
24Toxoplasmosis_Homo sapiens_hsa051451.49065176
25Legionellosis_Homo sapiens_hsa051341.47182505
26Hematopoietic cell lineage_Homo sapiens_hsa046401.37973250
27Vitamin digestion and absorption_Homo sapiens_hsa049771.35603798
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35263305
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.33573129
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31352337
31Viral myocarditis_Homo sapiens_hsa054161.31026408
32TNF signaling pathway_Homo sapiens_hsa046681.30287933
33Phagosome_Homo sapiens_hsa041451.26347294
34T cell receptor signaling pathway_Homo sapiens_hsa046601.26080051
35Type I diabetes mellitus_Homo sapiens_hsa049401.24802978
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24182956
37Antigen processing and presentation_Homo sapiens_hsa046121.22806035
38Platelet activation_Homo sapiens_hsa046111.22461502
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.20934379
40Herpes simplex infection_Homo sapiens_hsa051681.18002388
41Hepatitis C_Homo sapiens_hsa051601.12352828
42Other glycan degradation_Homo sapiens_hsa005111.11534606
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09346651
44GnRH signaling pathway_Homo sapiens_hsa049121.05874524
45Pertussis_Homo sapiens_hsa051331.05301946
46Hepatitis B_Homo sapiens_hsa051611.04866328
47Salmonella infection_Homo sapiens_hsa051321.01559263
48Galactose metabolism_Homo sapiens_hsa000521.00574218
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00166680
50Non-small cell lung cancer_Homo sapiens_hsa052230.98816421
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90226642
52Amoebiasis_Homo sapiens_hsa051460.88544924
53Shigellosis_Homo sapiens_hsa051310.86197782
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85211746
55Dorso-ventral axis formation_Homo sapiens_hsa043200.84768098
56Pancreatic cancer_Homo sapiens_hsa052120.84451054
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.82540304
58Complement and coagulation cascades_Homo sapiens_hsa046100.82285856
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81727460
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.81415155
61VEGF signaling pathway_Homo sapiens_hsa043700.80133154
62Renal cell carcinoma_Homo sapiens_hsa052110.79442041
63Rheumatoid arthritis_Homo sapiens_hsa053230.78792023
64Chronic myeloid leukemia_Homo sapiens_hsa052200.77158253
65Asthma_Homo sapiens_hsa053100.76728872
66Prolactin signaling pathway_Homo sapiens_hsa049170.75832025
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.74061808
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72366098
69Lysosome_Homo sapiens_hsa041420.72330225
70Type II diabetes mellitus_Homo sapiens_hsa049300.72251324
71Apoptosis_Homo sapiens_hsa042100.71609705
72Inositol phosphate metabolism_Homo sapiens_hsa005620.71546448
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.70557055
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70526465
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69157416
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68987176
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68707973
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.67087600
79FoxO signaling pathway_Homo sapiens_hsa040680.66695993
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.65634646
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.65405506
82Endocytosis_Homo sapiens_hsa041440.63139809
83Notch signaling pathway_Homo sapiens_hsa043300.62686013
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58123604
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57959665
86Insulin resistance_Homo sapiens_hsa049310.54775984
87Mineral absorption_Homo sapiens_hsa049780.53693862
88Choline metabolism in cancer_Homo sapiens_hsa052310.52295511
89Regulation of autophagy_Homo sapiens_hsa041400.50185219
90Endometrial cancer_Homo sapiens_hsa052130.49147623
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47285939
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46689864
93Rap1 signaling pathway_Homo sapiens_hsa040150.45035776
94MAPK signaling pathway_Homo sapiens_hsa040100.44666855
95Viral carcinogenesis_Homo sapiens_hsa052030.44533351
96HIF-1 signaling pathway_Homo sapiens_hsa040660.41146792
97mTOR signaling pathway_Homo sapiens_hsa041500.40313829
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39473768
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.39424579
100Arachidonic acid metabolism_Homo sapiens_hsa005900.36214328

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