OR51B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.95368869
2sensory perception of smell (GO:0007608)6.23137678
3nuclear pore organization (GO:0006999)5.93013976
4regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.37047904
5* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.30771477
6pore complex assembly (GO:0046931)5.15213310
7peptidyl-threonine dephosphorylation (GO:0035970)5.08635826
8regulation of acyl-CoA biosynthetic process (GO:0050812)4.82710433
9regulation of coenzyme metabolic process (GO:0051196)4.60804222
10regulation of cofactor metabolic process (GO:0051193)4.60804222
11DNA topological change (GO:0006265)4.56427014
12regulation of translational fidelity (GO:0006450)4.42893633
13regulation of sulfur metabolic process (GO:0042762)4.42879565
14formation of translation preinitiation complex (GO:0001731)4.37466311
15maturation of 5.8S rRNA (GO:0000460)4.32256669
16ribosome assembly (GO:0042255)4.23329962
17mitotic sister chromatid segregation (GO:0000070)4.22235183
18sister chromatid segregation (GO:0000819)4.18393480
19protoporphyrinogen IX biosynthetic process (GO:0006782)4.10098390
20negative regulation of smooth muscle cell differentiation (GO:0051151)4.06004443
21protoporphyrinogen IX metabolic process (GO:0046501)4.02510122
22establishment of integrated proviral latency (GO:0075713)4.01301606
23meiotic chromosome segregation (GO:0045132)3.99923439
24mitotic metaphase plate congression (GO:0007080)3.99325276
25DNA unwinding involved in DNA replication (GO:0006268)3.92041392
26folic acid-containing compound biosynthetic process (GO:0009396)3.83200342
27mitotic nuclear envelope disassembly (GO:0007077)3.83085195
28keratinocyte proliferation (GO:0043616)3.80492519
29regulation of mitotic spindle organization (GO:0060236)3.69632236
30microtubule depolymerization (GO:0007019)3.69628601
31non-recombinational repair (GO:0000726)3.69620293
32double-strand break repair via nonhomologous end joining (GO:0006303)3.69620293
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67564763
34DNA replication checkpoint (GO:0000076)3.66801452
35regulation of centriole replication (GO:0046599)3.63942532
36tRNA aminoacylation for protein translation (GO:0006418)3.63907234
37nucleobase-containing small molecule interconversion (GO:0015949)3.59996834
38synapsis (GO:0007129)3.57788918
39tRNA aminoacylation (GO:0043039)3.54995221
40amino acid activation (GO:0043038)3.54995221
41membrane disassembly (GO:0030397)3.54621610
42nuclear envelope disassembly (GO:0051081)3.54621610
43pteridine-containing compound biosynthetic process (GO:0042559)3.49175693
44ribosomal large subunit biogenesis (GO:0042273)3.49132215
45metaphase plate congression (GO:0051310)3.47916892
46protein localization to chromosome, centromeric region (GO:0071459)3.45038711
47IMP biosynthetic process (GO:0006188)3.41679316
48mitotic recombination (GO:0006312)3.38611430
49positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.33386037
50sensory perception of chemical stimulus (GO:0007606)3.32496761
51telomere maintenance via semi-conservative replication (GO:0032201)3.30632268
52protein localization to kinetochore (GO:0034501)3.30034475
53DNA ligation (GO:0006266)3.29133482
54transcription from mitochondrial promoter (GO:0006390)3.28911788
55* detection of chemical stimulus involved in sensory perception (GO:0050907)3.25045423
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23663871
57mitotic spindle checkpoint (GO:0071174)3.20601753
58DNA strand elongation involved in DNA replication (GO:0006271)3.20540388
59regulation of RNA export from nucleus (GO:0046831)3.19668259
60mitotic sister chromatid cohesion (GO:0007064)3.18839902
61regulation of centrosome cycle (GO:0046605)3.18078358
62transcription elongation from RNA polymerase I promoter (GO:0006362)3.17965258
63mitotic chromosome condensation (GO:0007076)3.16464490
64response to insecticide (GO:0017085)3.11821711
65chromosome segregation (GO:0007059)3.10897436
66positive regulation of developmental pigmentation (GO:0048087)3.09938780
67termination of RNA polymerase I transcription (GO:0006363)3.07552743
68aspartate family amino acid biosynthetic process (GO:0009067)3.07352021
69DNA replication initiation (GO:0006270)3.07052925
70telomere maintenance via recombination (GO:0000722)3.06764932
71ribosome biogenesis (GO:0042254)3.06670476
72spindle checkpoint (GO:0031577)3.06576181
73DNA double-strand break processing (GO:0000729)3.05666421
74rRNA methylation (GO:0031167)3.04956701
75regulation of pigment cell differentiation (GO:0050932)3.04499044
76DNA strand elongation (GO:0022616)3.03913823
77positive regulation of histone H3-K4 methylation (GO:0051571)3.02191352
78replication fork processing (GO:0031297)3.02067483
79centriole replication (GO:0007099)3.01660319
80kinetochore organization (GO:0051383)3.01445799
81chaperone-mediated protein complex assembly (GO:0051131)3.00915280
82positive regulation of chromosome segregation (GO:0051984)3.00653869
83purine nucleobase biosynthetic process (GO:0009113)3.00057067
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98813627
85resolution of meiotic recombination intermediates (GO:0000712)2.97104113
86regulation of spindle organization (GO:0090224)2.95829323
87centriole assembly (GO:0098534)2.95565454
88regulation of chromosome segregation (GO:0051983)2.95171384
89regulation of sister chromatid cohesion (GO:0007063)2.93851007
90regulation of centrosome duplication (GO:0010824)2.93438706
91mitochondrial DNA metabolic process (GO:0032042)2.92831972
92regulation of translational elongation (GO:0006448)2.89282231
93DNA geometric change (GO:0032392)2.87228578
94mitotic spindle assembly checkpoint (GO:0007094)2.85651790
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85333659
96negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85333659
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.85333659
98negative regulation of sister chromatid segregation (GO:0033046)2.85333659
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85333659
100negative regulation of chromosome segregation (GO:0051985)2.84769010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.73986951
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.91793418
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.55761369
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42909954
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.93933103
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.86438375
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.37727790
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.19315375
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.91009485
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.87932794
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.80481558
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76705640
13AR_21909140_ChIP-Seq_LNCAP_Human2.73450853
14GATA1_22025678_ChIP-Seq_K562_Human2.59426001
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58900656
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56772298
17DCP1A_22483619_ChIP-Seq_HELA_Human2.56745265
18ELK1_19687146_ChIP-ChIP_HELA_Human2.47486280
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33576377
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30300607
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29332356
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24724001
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.17337560
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16378700
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12013232
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08580570
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08118361
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.07611697
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98860404
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97163768
31VDR_23849224_ChIP-Seq_CD4+_Human1.96712751
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93229797
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.92972563
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85113178
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79319243
36TTF2_22483619_ChIP-Seq_HELA_Human1.77743315
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77151497
38XRN2_22483619_ChIP-Seq_HELA_Human1.76885466
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76462042
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.67412360
41FOXP3_21729870_ChIP-Seq_TREG_Human1.66494316
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63294891
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59007414
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54144666
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50357135
46GABP_19822575_ChIP-Seq_HepG2_Human1.45821519
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43738568
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39906822
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39750304
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34364131
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.33572486
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27896240
53KDM5A_27292631_Chip-Seq_BREAST_Human1.25325263
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23493813
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20631057
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18021036
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13788309
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11177911
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10426368
60IGF1R_20145208_ChIP-Seq_DFB_Human1.08145891
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05143572
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02826029
63FUS_26573619_Chip-Seq_HEK293_Human1.02187547
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01066756
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00515032
66EWS_26573619_Chip-Seq_HEK293_Human0.99575512
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99353525
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97090921
69MYC_18940864_ChIP-ChIP_HL60_Human0.96837384
70NCOR1_26117541_ChIP-Seq_K562_Human0.96137224
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95011050
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93324968
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92268842
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92236144
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90248048
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89946094
77TFEB_21752829_ChIP-Seq_HELA_Human0.88666304
78CHD1_26751641_Chip-Seq_LNCaP_Human0.87885357
79FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87153042
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.85671886
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83749471
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81422760
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77503219
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77285724
85ATF3_27146783_Chip-Seq_COLON_Human0.76726415
86VDR_22108803_ChIP-Seq_LS180_Human0.76312766
87GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75445953
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70803446
89HIF1A_21447827_ChIP-Seq_MCF-7_Human0.70236559
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68226818
91ELF5_23300383_ChIP-Seq_T47D_Human0.68137042
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67659496
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67659496
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67659496
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.67649565
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.66346675
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.64661575
98ZNF263_19887448_ChIP-Seq_K562_Human0.64188932
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.62888094
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62801541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.99433894
2MP0008057_abnormal_DNA_replication4.89670250
3MP0009697_abnormal_copulation4.67901360
4MP0008058_abnormal_DNA_repair4.09632498
5MP0004957_abnormal_blastocyst_morpholog3.83930393
6MP0003111_abnormal_nucleus_morphology3.75410103
7MP0003693_abnormal_embryo_hatching3.59105723
8MP0003077_abnormal_cell_cycle3.18498004
9MP0008007_abnormal_cellular_replicative3.13741174
10MP0004147_increased_porphyrin_level2.68759522
11MP0002877_abnormal_melanocyte_morpholog2.55805637
12MP0004185_abnormal_adipocyte_glucose2.47563058
13MP0003718_maternal_effect2.24871991
14MP0008932_abnormal_embryonic_tissue2.19674054
15MP0002009_preneoplasia2.09234087
16MP0010234_abnormal_vibrissa_follicle2.05593149
17MP0003786_premature_aging2.05451769
18MP0001661_extended_life_span1.90874508
19MP0006036_abnormal_mitochondrial_physio1.81063377
20MP0008961_abnormal_basal_metabolism1.80489410
21MP0000350_abnormal_cell_proliferation1.77034265
22MP0006035_abnormal_mitochondrial_morpho1.70636799
23MP0008995_early_reproductive_senescence1.66670806
24MP0001697_abnormal_embryo_size1.64360096
25MP0002396_abnormal_hematopoietic_system1.62168204
26MP0001730_embryonic_growth_arrest1.61867931
27MP0001873_stomach_inflammation1.45954189
28MP0004808_abnormal_hematopoietic_stem1.43324155
29MP0000313_abnormal_cell_death1.43267691
30MP0010678_abnormal_skin_adnexa1.42166419
31MP0010307_abnormal_tumor_latency1.40208694
32MP0004264_abnormal_extraembryonic_tissu1.40189456
33MP0001672_abnormal_embryogenesis/_devel1.38021602
34MP0005380_embryogenesis_phenotype1.38021602
35MP0003890_abnormal_embryonic-extraembry1.35451330
36MP0003656_abnormal_erythrocyte_physiolo1.34660785
37MP0003186_abnormal_redox_activity1.32154914
38MP0003984_embryonic_growth_retardation1.30270889
39MP0001929_abnormal_gametogenesis1.29343808
40MP0002080_prenatal_lethality1.26093066
41MP0002088_abnormal_embryonic_growth/wei1.25472113
42MP0001881_abnormal_mammary_gland1.25191967
43MP0001545_abnormal_hematopoietic_system1.22990411
44MP0005397_hematopoietic_system_phenotyp1.22990411
45MP0010352_gastrointestinal_tract_polyps1.20727906
46MP0002210_abnormal_sex_determination1.19608308
47MP0002019_abnormal_tumor_incidence1.19180570
48MP0003806_abnormal_nucleotide_metabolis1.19056718
49MP0002086_abnormal_extraembryonic_tissu1.16434647
50MP0004197_abnormal_fetal_growth/weight/1.14569022
51MP0000358_abnormal_cell_content/1.14273621
52MP0003221_abnormal_cardiomyocyte_apopto1.13874554
53MP0002234_abnormal_pharynx_morphology1.11844245
54MP0001293_anophthalmia1.11707397
55MP0002084_abnormal_developmental_patter1.10885553
56MP0002970_abnormal_white_adipose1.09627307
57MP0003943_abnormal_hepatobiliary_system1.04576518
58MP0001145_abnormal_male_reproductive0.97021653
59MP0006292_abnormal_olfactory_placode0.96760697
60MP0000383_abnormal_hair_follicle0.94955972
61MP0002160_abnormal_reproductive_system0.93967446
62MP0005451_abnormal_body_composition0.93440893
63MP0000653_abnormal_sex_gland0.89884378
64MP0008873_increased_physiological_sensi0.89261956
65MP0002095_abnormal_skin_pigmentation0.88757317
66MP0001764_abnormal_homeostasis0.88223293
67MP0002085_abnormal_embryonic_tissue0.87182829
68MP0003950_abnormal_plasma_membrane0.85286557
69MP0003698_abnormal_male_reproductive0.81190481
70MP0009703_decreased_birth_body0.80805086
71MP0000427_abnormal_hair_cycle0.79807629
72MP0001727_abnormal_embryo_implantation0.79344513
73MP0004233_abnormal_muscle_weight0.79219671
74MP0000647_abnormal_sebaceous_gland0.79172703
75MP0003941_abnormal_skin_development0.78313524
76MP0009115_abnormal_fat_cell0.77538895
77MP0001286_abnormal_eye_development0.73705029
78MP0002269_muscular_atrophy0.71767584
79MP0003699_abnormal_female_reproductive0.70455254
80MP0005076_abnormal_cell_differentiation0.67817775
81MP0005084_abnormal_gallbladder_morpholo0.67583814
82MP0009780_abnormal_chondrocyte_physiolo0.66787120
83MP0005384_cellular_phenotype0.66581723
84MP0005266_abnormal_metabolism0.66466420
85MP0005408_hypopigmentation0.66261345
86MP0003315_abnormal_perineum_morphology0.65472831
87MP0000703_abnormal_thymus_morphology0.64446058
88MP0005666_abnormal_adipose_tissue0.63957536
89MP0005636_abnormal_mineral_homeostasis0.63804686
90MP0003385_abnormal_body_wall0.63713590
91MP0000678_abnormal_parathyroid_gland0.63429317
92MP0002161_abnormal_fertility/fecundity0.63300926
93MP0002697_abnormal_eye_size0.62712717
94MP0002006_tumorigenesis0.61414478
95MP0002092_abnormal_eye_morphology0.61409740
96MP0008775_abnormal_heart_ventricle0.60170688
97MP0000609_abnormal_liver_physiology0.59598194
98MP0000569_abnormal_digit_pigmentation0.59077767
99MP0001348_abnormal_lacrimal_gland0.58581435
100MP0002971_abnormal_brown_adipose0.58353448

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.42345544
2Chromsome breakage (HP:0040012)6.40471694
3Abnormality of the preputium (HP:0100587)4.18422189
4Abnormality of chromosome stability (HP:0003220)4.16517234
5Aplasia/Hypoplasia of the uvula (HP:0010293)4.09916005
6Progressive external ophthalmoplegia (HP:0000590)3.76008520
7Acute myeloid leukemia (HP:0004808)3.49207616
8Meckel diverticulum (HP:0002245)3.48931651
9Duodenal stenosis (HP:0100867)3.43810069
10Small intestinal stenosis (HP:0012848)3.43810069
11Myelodysplasia (HP:0002863)3.35724302
12Multiple enchondromatosis (HP:0005701)3.31717255
13Abnormality of the ileum (HP:0001549)3.28677191
14Abnormality of glycolysis (HP:0004366)3.27600520
15Increased serum pyruvate (HP:0003542)3.05000405
16Cortical dysplasia (HP:0002539)3.04549708
17Birth length less than 3rd percentile (HP:0003561)3.03871942
18Ankyloglossia (HP:0010296)2.98428786
19Reticulocytopenia (HP:0001896)2.83933430
20Insomnia (HP:0100785)2.79479007
21Abnormal gallbladder physiology (HP:0012438)2.75233320
22Cholecystitis (HP:0001082)2.75233320
23Abnormality of the carotid arteries (HP:0005344)2.74140243
24Duplicated collecting system (HP:0000081)2.72960561
25Pili torti (HP:0003777)2.72072391
26Nephroblastoma (Wilms tumor) (HP:0002667)2.65480555
27Aplasia/Hypoplasia of the earlobes (HP:0009906)2.63975952
28Increased nuchal translucency (HP:0010880)2.63098304
29Abnormality of the duodenum (HP:0002246)2.61380449
30Cafe-au-lait spot (HP:0000957)2.59840167
31Volvulus (HP:0002580)2.56962414
32Sloping forehead (HP:0000340)2.56545202
33Truncus arteriosus (HP:0001660)2.54206023
34Diaphragmatic weakness (HP:0009113)2.48392251
35Clubbing of toes (HP:0100760)2.47948694
36Pheochromocytoma (HP:0002666)2.46881058
37Hypoplasia of the pons (HP:0012110)2.45675119
38Embryonal renal neoplasm (HP:0011794)2.45579197
39Abnormal lung lobation (HP:0002101)2.44798176
40Papillary thyroid carcinoma (HP:0002895)2.43285670
41Abnormality of reticulocytes (HP:0004312)2.40501874
42Abnormality of the renal collecting system (HP:0004742)2.38750708
43Abnormality of DNA repair (HP:0003254)2.36686224
44Aplastic anemia (HP:0001915)2.34052238
45Large hands (HP:0001176)2.31356650
46Long foot (HP:0001833)2.31236359
47Abnormality of the pons (HP:0007361)2.26980403
48Sandal gap (HP:0001852)2.21275967
49Neuroendocrine neoplasm (HP:0100634)2.20864211
50Reticulocytosis (HP:0001923)2.19929033
51Abnormality of oral frenula (HP:0000190)2.14431266
52Conjugated hyperbilirubinemia (HP:0002908)2.13434910
53Palpitations (HP:0001962)2.10761118
54Missing ribs (HP:0000921)2.09989892
55Abnormality of alanine metabolism (HP:0010916)2.07430972
56Hyperalaninemia (HP:0003348)2.07430972
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07430972
58Choanal atresia (HP:0000453)2.00739912
59Acanthocytosis (HP:0001927)2.00238356
60Squamous cell carcinoma (HP:0002860)1.98559060
61Increased serum lactate (HP:0002151)1.95570181
62Neoplasm of the adrenal gland (HP:0100631)1.93638520
63Neuroblastic tumors (HP:0004376)1.93094308
64Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.93094308
65Neuroblastoma (HP:0003006)1.93094308
66Primitive neuroectodermal tumor (HP:0030065)1.93094308
67Upper limb muscle weakness (HP:0003484)1.89546584
68Poikilocytosis (HP:0004447)1.89316147
69Arteriovenous malformation (HP:0100026)1.87683199
70Pallor (HP:0000980)1.87309463
71Absent thumb (HP:0009777)1.86057442
72Hypertensive crisis (HP:0100735)1.83107761
73Abnormal auditory evoked potentials (HP:0006958)1.83014681
74Neoplasm of the colon (HP:0100273)1.81485042
75Neoplasm of the peripheral nervous system (HP:0100007)1.81427006
76Embryonal neoplasm (HP:0002898)1.80865400
77Rhabdomyosarcoma (HP:0002859)1.80490605
78Abnormality of cells of the erythroid lineage (HP:0012130)1.80384919
79Acute lymphatic leukemia (HP:0006721)1.80374415
80Short middle phalanx of the 5th finger (HP:0004220)1.78934428
81Ovarian neoplasm (HP:0100615)1.78904618
82Bone marrow hypocellularity (HP:0005528)1.78887317
83Microvesicular hepatic steatosis (HP:0001414)1.77594830
84Progressive muscle weakness (HP:0003323)1.75087235
85Increased hepatocellular lipid droplets (HP:0006565)1.74174890
86Horseshoe kidney (HP:0000085)1.73277600
87Lactic acidosis (HP:0003128)1.70689837
88Freckling (HP:0001480)1.69045604
89Cholelithiasis (HP:0001081)1.67848838
90Triphalangeal thumb (HP:0001199)1.66925347
91Chronic bronchitis (HP:0004469)1.66418993
92Cortical visual impairment (HP:0100704)1.65677989
93Delusions (HP:0000746)1.64909229
94Tinnitus (HP:0000360)1.64866479
95Neoplasm of the small intestine (HP:0100833)1.63852346
96Thyroid carcinoma (HP:0002890)1.63527871
97Abnormality of the tricuspid valve (HP:0001702)1.61559324
98Cystic hygroma (HP:0000476)1.60820278
99Premature ovarian failure (HP:0008209)1.60686796
100Entropion (HP:0000621)1.59804847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.97227395
2PBK4.24054659
3TNIK4.08938342
4BUB13.35893391
5EIF2AK33.22869611
6MST1R3.21396897
7EIF2AK13.08758128
8TTK3.01485905
9TSSK62.69324346
10WEE12.62239727
11PLK42.40672621
12NME12.36531861
13BMPR22.36224869
14NEK12.30459330
15SCYL22.22086337
16CDC72.15326431
17BRSK22.10938395
18MKNK11.98416348
19CCNB11.92445638
20STK391.69996558
21WNK41.65966408
22FGFR11.64002886
23MKNK21.62088269
24MAP3K121.59356590
25ERBB31.49750112
26PLK31.48127115
27RIPK41.44681264
28STK101.40644140
29NEK21.38463857
30PDK21.33935107
31SRPK11.33687862
32ZAK1.22460634
33CHEK21.21364737
34EIF2AK21.13284614
35STK161.10315302
36EEF2K1.05240170
37ERBB41.04967838
38RPS6KB21.04450400
39PLK11.03593581
40NME21.01024912
41BRSK11.00512521
42MET1.00430305
43BRD40.91521123
44MAP3K20.88822041
45RAF10.88732661
46MAPKAPK50.88065889
47ATR0.86654468
48TRIM280.86123912
49STK30.84122146
50MAP3K80.83399155
51PNCK0.78500147
52CHEK10.77269302
53KSR20.75207470
54TRPM70.73932018
55WNK10.72273793
56BCR0.70183026
57ATM0.67436616
58BMX0.66380430
59AURKB0.65720930
60CDK80.64593851
61ALK0.63271786
62KSR10.60256011
63STK40.56526155
64BMPR1B0.55815746
65LRRK20.54390501
66CLK10.52072065
67CSNK2A20.51748433
68NUAK10.51552635
69RPS6KA40.50791087
70NTRK30.49247320
71NEK60.48217454
72LATS10.47187193
73CDK70.46799749
74MAP3K140.46114328
75NLK0.42946538
76CDK10.42563905
77MELK0.41285457
78PAK40.41236919
79CDK60.41128000
80PKN20.39965574
81TAF10.39189686
82AKT20.38396388
83VRK10.36495490
84MAPKAPK30.31716956
85CDK20.31686150
86CDK40.30997890
87YES10.30430629
88AKT30.30217014
89LATS20.30103759
90CSNK1E0.29738200
91PRKCI0.27381957
92RPS6KB10.25181252
93CSNK2A10.24541388
94SIK30.23812583
95DAPK10.23517310
96MAP3K40.21558565
97NEK90.19725245
98BRAF0.18172575
99ACVR1B0.15797225
100PASK0.14762899

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.20712514
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82119820
3Non-homologous end-joining_Homo sapiens_hsa034503.66596638
4Mismatch repair_Homo sapiens_hsa034303.29301246
5Homologous recombination_Homo sapiens_hsa034403.09231869
6* Olfactory transduction_Homo sapiens_hsa047403.09062730
7DNA replication_Homo sapiens_hsa030303.06283174
8One carbon pool by folate_Homo sapiens_hsa006702.84977396
9Fanconi anemia pathway_Homo sapiens_hsa034602.81339528
10RNA transport_Homo sapiens_hsa030132.66836537
11Basal transcription factors_Homo sapiens_hsa030222.59445350
12Vitamin B6 metabolism_Homo sapiens_hsa007502.49929658
13Nucleotide excision repair_Homo sapiens_hsa034202.48050135
14Cell cycle_Homo sapiens_hsa041102.44542266
15Proteasome_Homo sapiens_hsa030502.37956053
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18894465
17RNA degradation_Homo sapiens_hsa030182.18773687
18RNA polymerase_Homo sapiens_hsa030202.18653045
19Pyruvate metabolism_Homo sapiens_hsa006202.15642179
20Spliceosome_Homo sapiens_hsa030401.97092700
21Ribosome_Homo sapiens_hsa030101.88315775
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.83008335
23Base excision repair_Homo sapiens_hsa034101.69017124
24Pyrimidine metabolism_Homo sapiens_hsa002401.65981353
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58995892
26Propanoate metabolism_Homo sapiens_hsa006401.56629158
27mRNA surveillance pathway_Homo sapiens_hsa030151.47966008
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46850106
29Protein export_Homo sapiens_hsa030601.35686422
30p53 signaling pathway_Homo sapiens_hsa041151.31137816
31Selenocompound metabolism_Homo sapiens_hsa004501.27550259
32Thyroid cancer_Homo sapiens_hsa052161.27447904
33Purine metabolism_Homo sapiens_hsa002301.25035288
34Carbon metabolism_Homo sapiens_hsa012001.13285421
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09966574
36Oocyte meiosis_Homo sapiens_hsa041141.05872764
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03711871
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01965139
39Biosynthesis of amino acids_Homo sapiens_hsa012300.96884155
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95123137
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80584293
42Glutathione metabolism_Homo sapiens_hsa004800.77803221
43Fatty acid biosynthesis_Homo sapiens_hsa000610.76051072
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69629483
45Parkinsons disease_Homo sapiens_hsa050120.67631830
46Chronic myeloid leukemia_Homo sapiens_hsa052200.65174445
47Sulfur metabolism_Homo sapiens_hsa009200.63308667
48ErbB signaling pathway_Homo sapiens_hsa040120.63209285
49Huntingtons disease_Homo sapiens_hsa050160.62125536
50Folate biosynthesis_Homo sapiens_hsa007900.62026073
51Steroid biosynthesis_Homo sapiens_hsa001000.58454012
52Pancreatic cancer_Homo sapiens_hsa052120.55635214
53Oxidative phosphorylation_Homo sapiens_hsa001900.54496968
54Epstein-Barr virus infection_Homo sapiens_hsa051690.53022866
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51865782
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49827474
57Viral carcinogenesis_Homo sapiens_hsa052030.48948318
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48054971
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44335567
60Pentose phosphate pathway_Homo sapiens_hsa000300.42589018
61Adherens junction_Homo sapiens_hsa045200.42391418
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38309904
63Acute myeloid leukemia_Homo sapiens_hsa052210.37085685
64MicroRNAs in cancer_Homo sapiens_hsa052060.36838705
65Prostate cancer_Homo sapiens_hsa052150.36609378
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.36041046
67Colorectal cancer_Homo sapiens_hsa052100.33434144
68TGF-beta signaling pathway_Homo sapiens_hsa043500.32925764
69Metabolic pathways_Homo sapiens_hsa011000.31898794
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25016120
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24642294
72Fatty acid metabolism_Homo sapiens_hsa012120.24581447
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22291861
74Sphingolipid metabolism_Homo sapiens_hsa006000.21748560
75Butanoate metabolism_Homo sapiens_hsa006500.21482288
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20896749
77HTLV-I infection_Homo sapiens_hsa051660.20423763
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20086250
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19988242
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19486865
81Melanogenesis_Homo sapiens_hsa049160.19336109
82Non-small cell lung cancer_Homo sapiens_hsa052230.19052690
83Alzheimers disease_Homo sapiens_hsa050100.18052847
84Renal cell carcinoma_Homo sapiens_hsa052110.17815802
85Wnt signaling pathway_Homo sapiens_hsa043100.17753402
86Arginine biosynthesis_Homo sapiens_hsa002200.17366646
87mTOR signaling pathway_Homo sapiens_hsa041500.15945336
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.15768224
89Arginine and proline metabolism_Homo sapiens_hsa003300.15600068
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14700463
91Fructose and mannose metabolism_Homo sapiens_hsa000510.14515117
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11814173
93Phenylalanine metabolism_Homo sapiens_hsa003600.11457527
94Hepatitis B_Homo sapiens_hsa051610.11148005
95Herpes simplex infection_Homo sapiens_hsa051680.10346955
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.10300651
97Peroxisome_Homo sapiens_hsa041460.07467731
98Apoptosis_Homo sapiens_hsa042100.07284227
99Pathways in cancer_Homo sapiens_hsa052000.05516239
100Melanoma_Homo sapiens_hsa052180.04933197

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