OR4A47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.76372686
2positive regulation of RNA splicing (GO:0033120)9.71167292
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.29654766
4cAMP biosynthetic process (GO:0006171)8.94566993
5negative regulation of alpha-beta T cell differentiation (GO:0046639)8.45317342
6enteric nervous system development (GO:0048484)7.97024195
7regulation of protein sumoylation (GO:0033233)7.60285988
8synaptic transmission, dopaminergic (GO:0001963)7.19426106
9dendritic spine morphogenesis (GO:0060997)7.05176261
10positive regulation of mitochondrial fission (GO:0090141)7.01096510
11righting reflex (GO:0060013)6.99849822
12* detection of chemical stimulus involved in sensory perception (GO:0050907)6.95094788
13heterotypic cell-cell adhesion (GO:0034113)6.65583204
14positive regulation of T-helper 1 type immune response (GO:0002827)6.37974751
15icosanoid secretion (GO:0032309)6.12172806
16arachidonic acid secretion (GO:0050482)6.12172806
17hepatocyte apoptotic process (GO:0097284)6.08481694
18endothelial cell differentiation (GO:0045446)6.01156606
19positive regulation of T-helper cell differentiation (GO:0045624)5.84730982
20phosphatidylinositol acyl-chain remodeling (GO:0036149)5.59074060
21phosphatidylserine acyl-chain remodeling (GO:0036150)5.32004549
22drug transmembrane transport (GO:0006855)5.28175839
23phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.18276559
24regulation of mitochondrial fission (GO:0090140)5.15586272
25fatty acid derivative transport (GO:1901571)5.07142373
26icosanoid transport (GO:0071715)5.07142373
27neuronal ion channel clustering (GO:0045161)5.04470948
28* detection of chemical stimulus (GO:0009593)4.98507466
29negative regulation of alpha-beta T cell activation (GO:0046636)4.96708686
30chemosensory behavior (GO:0007635)4.84490030
31hyaluronan catabolic process (GO:0030214)4.82404174
32neural tube formation (GO:0001841)4.78679226
33regulation of T-helper 1 type immune response (GO:0002825)4.59872069
34embryonic digestive tract morphogenesis (GO:0048557)4.50730860
35cilium or flagellum-dependent cell motility (GO:0001539)4.48750041
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.46683779
37cyclic purine nucleotide metabolic process (GO:0052652)4.46143607
38nephron tubule morphogenesis (GO:0072078)4.39397402
39nephron epithelium morphogenesis (GO:0072088)4.39397402
40vocalization behavior (GO:0071625)4.35234317
41ATP hydrolysis coupled proton transport (GO:0015991)4.33295154
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.33295154
43cyclic nucleotide biosynthetic process (GO:0009190)4.32152912
44retina layer formation (GO:0010842)4.31532796
45regulation of cAMP-mediated signaling (GO:0043949)4.30800554
46positive regulation of membrane potential (GO:0045838)4.29843534
47attachment of spindle microtubules to kinetochore (GO:0008608)4.29085790
48regulation of T-helper cell differentiation (GO:0045622)4.25523536
49cellular response to glucagon stimulus (GO:0071377)4.24474850
50negative regulation of actin filament bundle assembly (GO:0032232)4.23876231
51regulation of type 2 immune response (GO:0002828)4.22813046
52response to dietary excess (GO:0002021)4.21660666
53water transport (GO:0006833)4.11600932
54cAMP metabolic process (GO:0046058)4.03493435
55mitochondrial fusion (GO:0008053)4.03259125
56protein localization to synapse (GO:0035418)4.01826540
57dendritic spine organization (GO:0097061)4.01310326
58positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.92499364
59cellular zinc ion homeostasis (GO:0006882)3.89482894
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.89167423
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.84422132
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.75230411
63monoamine transport (GO:0015844)3.74496078
64negative regulation of T cell differentiation (GO:0045581)3.72820854
65positive regulation of protein targeting to membrane (GO:0090314)3.70568845
66fluid transport (GO:0042044)3.67614332
67drug transport (GO:0015893)3.60372399
68leukotriene biosynthetic process (GO:0019370)3.59767525
69cellular response to ATP (GO:0071318)3.59280437
70sulfur amino acid catabolic process (GO:0000098)3.51214787
71pre-miRNA processing (GO:0031054)3.49687394
72sequestering of metal ion (GO:0051238)3.49412541
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.43886141
74positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.38774065
75positive regulation of alpha-beta T cell differentiation (GO:0046638)3.36162929
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.36084372
77left/right axis specification (GO:0070986)3.35052486
78phosphatidylcholine acyl-chain remodeling (GO:0036151)3.26153064
79negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.22607024
80neuromuscular process controlling posture (GO:0050884)3.20634917
81renal tubule morphogenesis (GO:0061333)3.17056981
82response to glucagon (GO:0033762)3.16809260
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.16071987
84neurofilament cytoskeleton organization (GO:0060052)3.14120709
85prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.12145071
86adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.10857041
87negative regulation of astrocyte differentiation (GO:0048712)3.10473060
88adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.10312125
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08034754
90positive regulation of steroid hormone secretion (GO:2000833)3.03580128
91tooth mineralization (GO:0034505)14.4787064
92positive regulation of protein sumoylation (GO:0033235)12.0795024
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.5418284
94negative regulation of T-helper cell differentiation (GO:0045623)11.5418284
95* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)11.2358600
96protein K11-linked deubiquitination (GO:0035871)10.7022954
97regulation of T-helper 1 cell differentiation (GO:0045625)10.4033312
98regulation of T-helper 2 cell differentiation (GO:0045628)10.2497782
99negative regulation of type 2 immune response (GO:0002829)10.2382452
100activation of protein kinase A activity (GO:0034199)10.1755743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.95380905
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.96318660
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.76289002
4TP53_16413492_ChIP-PET_HCT116_Human2.26831191
5* AR_21572438_ChIP-Seq_LNCaP_Human2.17699818
6PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.16366214
7YY1_22570637_ChIP-Seq_MALME-3M_Human2.09753769
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02858805
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01836536
10POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.01836536
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.01585307
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse11.3193768
13GATA1_19941826_ChIP-Seq_K562_Human1.95421065
14NR3C1_23031785_ChIP-Seq_PC12_Mouse1.81318388
15DROSHA_22980978_ChIP-Seq_HELA_Human1.73900563
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72004238
17EGR1_19032775_ChIP-ChIP_M12_Human1.70040845
18RNF2_27304074_Chip-Seq_ESCs_Mouse1.67932173
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67898242
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.63878817
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56554843
22SMAD3_21741376_ChIP-Seq_HESCs_Human1.55761488
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.55022007
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51246665
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50953142
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48221587
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42278137
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.39971314
29RNF2_27304074_Chip-Seq_NSC_Mouse1.35029637
30TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.33641280
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.31249510
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25968983
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24145178
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.22918249
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22664186
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22605998
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22471729
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21376885
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.19168605
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17962553
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16400941
42HNFA_21074721_ChIP-Seq_CACO-2_Human1.14923573
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14247251
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11476021
45SOX2_18555785_Chip-Seq_ESCs_Mouse1.10980390
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10891110
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.10698798
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09701301
49EZH2_22144423_ChIP-Seq_EOC_Human1.08842281
50GATA6_21074721_ChIP-Seq_CACO-2_Human1.08257593
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08234693
52GBX2_23144817_ChIP-Seq_PC3_Human1.08097451
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07735000
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.07720180
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07147587
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.06277425
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04967804
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04107870
59TBL1_22424771_ChIP-Seq_293T_Human1.03890422
60SMAD4_21741376_ChIP-Seq_HESCs_Human1.02582995
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.02127808
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99266893
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98751659
64CJUN_26792858_Chip-Seq_BT549_Human0.98072300
65GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97590367
66* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97407681
67CTCF_27219007_Chip-Seq_Bcells_Human0.96345942
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95436916
69NANOG_16518401_ChIP-PET_MESCs_Mouse0.95122575
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93302932
71RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91680205
72EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91680205
73SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91379809
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91330347
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89728914
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89428752
77ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88670610
78NMYC_18555785_Chip-Seq_ESCs_Mouse0.88182741
79KLF4_18555785_Chip-Seq_ESCs_Mouse0.87658025
80E2F1_18555785_Chip-Seq_ESCs_Mouse0.87353858
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86780242
82REST_21632747_ChIP-Seq_MESCs_Mouse0.86223428
83GATA2_19941826_ChIP-Seq_K562_Human0.85347069
84RING1B_27294783_Chip-Seq_ESCs_Mouse0.83628654
85* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83183930
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.82575945
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81812217
88ISL1_27105846_Chip-Seq_CPCs_Mouse0.81225847
89* STAT3_23295773_ChIP-Seq_U87_Human0.80996752
90NANOG_20526341_ChIP-Seq_ESCs_Human0.80413029
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.79838543
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79831454
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79831454
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79831454
95* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79808903
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79788542
97P53_22387025_ChIP-Seq_ESCs_Mouse0.79038830
98SMAD4_21799915_ChIP-Seq_A2780_Human0.78516104
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78387108
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78358301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.74493093
2MP0004130_abnormal_muscle_cell4.97361861
3MP0004264_abnormal_extraembryonic_tissu4.00966166
4MP0003252_abnormal_bile_duct3.60750559
5MP0004133_heterotaxia2.80560713
6MP0002928_abnormal_bile_duct2.72028855
7MP0006072_abnormal_retinal_apoptosis2.44788360
8MP0005448_abnormal_energy_balance2.30543890
9MP0005408_hypopigmentation2.24248741
10MP0002751_abnormal_autonomic_nervous2.22814012
11MP0003329_amyloid_beta_deposits2.17796050
12MP0001270_distended_abdomen2.10693814
13MP0004272_abnormal_basement_membrane2.09788082
14MP0005084_abnormal_gallbladder_morpholo12.6219176
15MP0003943_abnormal_hepatobiliary_system1.72980307
16MP0005379_endocrine/exocrine_gland_phen1.65285115
17MP0005165_increased_susceptibility_to1.64998240
18MP0005220_abnormal_exocrine_pancreas1.64458200
19MP0001958_emphysema1.44796142
20MP0009764_decreased_sensitivity_to1.44504846
21MP0000604_amyloidosis1.41616447
22MP0001529_abnormal_vocalization1.35655560
23MP0003718_maternal_effect1.27114741
24MP0005646_abnormal_pituitary_gland1.04303903
25MP0000465_gastrointestinal_hemorrhage1.02922627
26MP0000470_abnormal_stomach_morphology1.01541142
27MP0002909_abnormal_adrenal_gland1.01123038
28MP0001905_abnormal_dopamine_level0.99494463
29MP0001944_abnormal_pancreas_morphology0.99145106
30MP0002572_abnormal_emotion/affect_behav0.96298283
31MP0008569_lethality_at_weaning0.91862506
32MP0003638_abnormal_response/metabolism_0.89604561
33MP0000371_diluted_coat_color0.83219459
34MP0008469_abnormal_protein_level0.82532401
35MP0005164_abnormal_response_to0.82160883
36MP0001915_intracranial_hemorrhage0.78987748
37MP0001800_abnormal_humoral_immune0.78086257
38MP0002405_respiratory_system_inflammati0.76293983
39MP0003866_abnormal_defecation0.74817169
40MP0004019_abnormal_vitamin_homeostasis0.74056618
41MP0003121_genomic_imprinting0.73766115
42MP0002693_abnormal_pancreas_physiology0.72359803
43MP0000609_abnormal_liver_physiology0.71782586
44MP0008875_abnormal_xenobiotic_pharmacok0.67412253
45MP0004947_skin_inflammation0.67200266
46MP0002098_abnormal_vibrissa_morphology0.67196334
47MP0000703_abnormal_thymus_morphology0.66170340
48MP0001851_eye_inflammation0.66063531
49MP0001533_abnormal_skeleton_physiology0.64320874
50MP0002136_abnormal_kidney_physiology0.63985722
51MP0005253_abnormal_eye_physiology0.63672323
52MP0005387_immune_system_phenotype0.63272945
53MP0001790_abnormal_immune_system0.63272945
54MP0002078_abnormal_glucose_homeostasis0.62727721
55MP0003953_abnormal_hormone_level0.60361348
56MP0002998_abnormal_bone_remodeling0.57584937
57MP0001845_abnormal_inflammatory_respons0.53049884
58MP0009642_abnormal_blood_homeostasis0.47698615
59MP0002722_abnormal_immune_system0.47488760
60MP0003195_calcinosis0.46814625
61MP0001986_abnormal_taste_sensitivity0.45417785
62MP0002419_abnormal_innate_immunity0.42901645
63MP0005551_abnormal_eye_electrophysiolog0.40576626
64MP0005334_abnormal_fat_pad0.38789307
65MP0002429_abnormal_blood_cell0.38695707
66MP0002822_catalepsy0.38162126
67MP0004484_altered_response_of0.37529761
68MP0002452_abnormal_antigen_presenting0.37513434
69MP0000759_abnormal_skeletal_muscle0.36137905
70MP0000920_abnormal_myelination0.36124517
71MP0000477_abnormal_intestine_morphology0.36088300
72MP0000598_abnormal_liver_morphology0.35458229
73MP0005423_abnormal_somatic_nervous0.34944374
74MP0002420_abnormal_adaptive_immunity0.34879379
75MP0001819_abnormal_immune_cell0.34073963
76MP0001835_abnormal_antigen_presentation0.33969927
77MP0009931_abnormal_skin_appearance0.33538817
78MP0005365_abnormal_bile_salt0.33464042
79MP0005390_skeleton_phenotype0.33213783
80MP0002882_abnormal_neuron_morphology0.32973175
81MP0000716_abnormal_immune_system0.32752259
82MP0005395_other_phenotype0.32275592
83MP0001501_abnormal_sleep_pattern0.31606662
84MP0002735_abnormal_chemical_nociception0.31599497
85MP0002723_abnormal_immune_serum0.31283714
86MP0008004_abnormal_stomach_pH0.31016292
87MP0002398_abnormal_bone_marrow0.30871777
88MP0002229_neurodegeneration0.29996241
89MP0001299_abnormal_eye_distance/0.29073321
90MP0005000_abnormal_immune_tolerance0.28613523
91MP0001175_abnormal_lung_morphology0.28359232
92MP0000689_abnormal_spleen_morphology0.25077745
93MP0005377_hearing/vestibular/ear_phenot0.24361121
94MP0003878_abnormal_ear_physiology0.24361121
95MP0009053_abnormal_anal_canal0.22638164
96MP0002066_abnormal_motor_capabilities/c0.22302259
97MP0002128_abnormal_blood_circulation0.21512599
98MP0009785_altered_susceptibility_to0.20644126
99MP0000249_abnormal_blood_vessel0.20257485
100MP0005391_vision/eye_phenotype0.18953009

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of dental color (HP:0011073)8.30916420
2Abnormality of renal resorption (HP:0011038)8.13629066
3Osteomalacia (HP:0002749)7.90163855
4Polyuria (HP:0000103)7.59976982
5Abnormality of the dental pulp (HP:0006479)7.57314779
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.79086942
7Abnormal urine output (HP:0012590)6.51226919
8Abnormality of renal excretion (HP:0011036)5.68247334
9Round ear (HP:0100830)5.54566229
10Chronic bronchitis (HP:0004469)4.91393789
11IgM deficiency (HP:0002850)4.28126517
12Volvulus (HP:0002580)4.26709751
13Lip pit (HP:0100267)4.23144191
14Autoimmune thrombocytopenia (HP:0001973)4.05955785
15Toxemia of pregnancy (HP:0100603)4.01684805
16Nephrocalcinosis (HP:0000121)3.91810683
17Esophageal varix (HP:0002040)3.87488739
18Abnormality of midbrain morphology (HP:0002418)3.81225808
19Molar tooth sign on MRI (HP:0002419)3.81225808
20Lipoatrophy (HP:0100578)3.46050676
21Depressed nasal tip (HP:0000437)3.41343701
22Sparse lateral eyebrow (HP:0005338)3.33469205
23Tachypnea (HP:0002789)3.30482480
24Large earlobe (HP:0009748)3.28288569
25Abnormal respiratory motile cilium physiology (HP:0012261)3.27787713
26Rhinitis (HP:0012384)3.26811866
27Drooling (HP:0002307)3.16984640
28Hypoparathyroidism (HP:0000829)3.14178144
29Intestinal fistula (HP:0100819)3.06990692
30Excessive salivation (HP:0003781)3.05215481
31Panhypogammaglobulinemia (HP:0003139)3.01353682
32Personality changes (HP:0000751)2.89486957
33Hyperphosphaturia (HP:0003109)2.88727264
34Thick eyebrow (HP:0000574)2.82312179
35Petechiae (HP:0000967)2.76787470
36Ureteral stenosis (HP:0000071)2.59873739
37Nephronophthisis (HP:0000090)2.59452474
38Dilated cardiomyopathy (HP:0001644)2.56492578
39Abnormality of the fingertips (HP:0001211)2.53018259
40Hepatitis (HP:0012115)2.52640075
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.47633218
42Short 5th finger (HP:0009237)2.43941027
43Abnormal urine phosphate concentration (HP:0012599)2.43544810
44Ureteral obstruction (HP:0006000)2.40300965
45Recurrent cutaneous fungal infections (HP:0011370)2.39244998
46Chronic mucocutaneous candidiasis (HP:0002728)2.39244998
47Striae distensae (HP:0001065)2.37674810
48Sudden cardiac death (HP:0001645)2.34134655
49Abnormality of urine glucose concentration (HP:0011016)2.33625666
50Glycosuria (HP:0003076)2.33625666
51Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.32500769
52Abnormality of transition element cation homeostasis (HP:0011030)2.31787289
53Gingival overgrowth (HP:0000212)2.31709885
54Colitis (HP:0002583)2.25599409
55Nephropathy (HP:0000112)2.24641559
56Hypercalciuria (HP:0002150)2.19793751
57Periauricular skin pits (HP:0100277)2.14257372
58Preauricular pit (HP:0004467)2.14257372
59Bronchitis (HP:0012387)2.14209251
60Recurrent otitis media (HP:0000403)2.13910238
61Inability to walk (HP:0002540)2.12220926
62Decreased muscle mass (HP:0003199)2.10773302
63Agammaglobulinemia (HP:0004432)2.09370961
64Abnormality of salivation (HP:0100755)2.00580401
65Chondrocalcinosis (HP:0000934)2.00293050
66Overgrowth (HP:0001548)12.3077597
67Amelogenesis imperfecta (HP:0000705)11.7049025
68Abnormality of calcium-phosphate metabolism (HP:0100530)10.1173842
69Anal stenosis (HP:0002025)1.98709033
70Delayed eruption of teeth (HP:0000684)1.97953615
71Abnormality of Sharpey fibers (HP:0100685)1.95396402
72Abnormality of the renal medulla (HP:0100957)1.91931202
73Chorioretinal coloboma (HP:0000567)1.85609841
74Ectopic kidney (HP:0000086)1.85199499
75Preauricular skin tag (HP:0000384)1.80339481
76Truncal ataxia (HP:0002078)1.79626336
77Renal tubular dysfunction (HP:0000124)1.78190730
78Prominent supraorbital ridges (HP:0000336)1.77648311
79Limited elbow extension (HP:0001377)1.74045599
80Stage 5 chronic kidney disease (HP:0003774)1.71362511
81Torticollis (HP:0000473)1.66829644
82Abnormality of small intestinal villus morphology (HP:0011472)1.64704192
83Villous atrophy (HP:0011473)1.64704192
84Palmoplantar keratoderma (HP:0000982)1.61013447
85Polyneuropathy (HP:0001271)1.58670015
86Oculomotor apraxia (HP:0000657)1.57874657
87Small hand (HP:0200055)1.57254670
88Ectropion (HP:0000656)1.57058904
89Bronchiectasis (HP:0002110)1.51362067
90Skin tags (HP:0010609)1.50866354
91Blepharitis (HP:0000498)1.49819368
92Prenatal maternal abnormality (HP:0002686)1.48480476
93Skin pits (HP:0100276)1.44005702
94Osteoarthritis (HP:0002758)1.43114435
95Viral hepatitis (HP:0006562)1.42660041
96Inflammation of the large intestine (HP:0002037)1.41588986
97Mask-like facies (HP:0000298)1.41024125
98Proximal placement of thumb (HP:0009623)1.39379564
99Highly arched eyebrow (HP:0002553)1.37880500
100Gastrointestinal inflammation (HP:0004386)1.28325250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.63966025
2BLK4.34801720
3STK34.14352194
4RIPK43.23045382
5CDC42BPA2.19375698
6BMPR22.11042441
7NTRK214.2096398
8HIPK21.20600874
9FGFR10.91884693
10ROCK20.80797199
11SYK0.69809627
12SRC0.64454828
13OBSCN0.60703862
14INSRR0.60238903
15PRKCQ0.58949338
16ROCK10.56937435
17PRKAA10.56748273
18MUSK0.56015653
19GRK70.50856835
20MAP4K20.49235045
21TXK0.47487807
22ADRBK20.45865904
23PRKACG0.44619468
24ABL10.42749413
25WNK30.41849880
26GRK10.41795532
27TIE10.41366650
28MAPK150.40581950
29PRKACA0.36935545
30PRKACB0.35730291
31SRPK10.33362826
32CAMK2A0.32911554
33ERBB40.31997556
34STK160.30727304
35DDR20.30201402
36PIK3CG0.28454048
37LYN0.26482191
38ITK0.25331300
39PLK10.25330066
40KDR0.24285303
41EPHA40.23181606
42PRKCA0.23162143
43TTN0.22874757
44PLK40.22787536
45MATK0.22747904
46MAPK140.22291671
47TLK10.21626085
48MST1R0.21509959
49GSK3B0.21367656
50PRKCB0.20992277
51LMTK20.20131143
52RPS6KA30.20010193
53FYN0.19080192
54KIT0.18631880
55TEC0.18496153
56PHKG10.17772559
57PHKG20.17772559
58GRK50.15452465
59CSNK1A10.15342414
60EPHA20.15192416
61PRKCD0.13981198
62CDK10.13741054
63BTK0.13375216
64PIM20.12937792
65OXSR10.12182475
66CHUK0.11402014
67LCK0.11210645
68GRK60.10917973
69MAPK90.10190818
70PRKDC0.10190450
71MAP2K60.09929478
72TNK20.09741864
73HCK0.09587050
74ADRBK10.09293435
75WNK40.09224589
76IGF1R0.07931874
77EGFR0.07895800
78PKN10.07819193
79PRKCG0.07722577
80CAMK2G0.06467855
81AKT10.06211038
82PIK3CA0.06143203
83CSK0.05426522
84TAOK20.05385271
85IKBKE0.05280581
86PRKG20.04970399
87INSR0.04900428
88PIM10.04654297
89ABL20.04138282
90TGFBR20.03954024
91TAOK30.03842220
92STK390.03765712
93PRKG10.03619467
94PINK10.03316158
95PRKCE0.03122598
96NTRK10.02724769
97MYLK0.02586808
98MOS0.01515228
99MAPK40.00980694
100CAMK2B0.00818744

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.82944368
2Sulfur metabolism_Homo sapiens_hsa009203.75259265
3* Olfactory transduction_Homo sapiens_hsa047403.69768995
4Ovarian steroidogenesis_Homo sapiens_hsa049133.48282583
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.37673096
6Linoleic acid metabolism_Homo sapiens_hsa005913.07757255
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.99279593
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.79969672
9Collecting duct acid secretion_Homo sapiens_hsa049662.53575397
10Bile secretion_Homo sapiens_hsa049762.45839646
11Vibrio cholerae infection_Homo sapiens_hsa051102.44693479
12Thyroid hormone synthesis_Homo sapiens_hsa049182.26727730
13Pancreatic secretion_Homo sapiens_hsa049722.26370880
14Fat digestion and absorption_Homo sapiens_hsa049752.19288690
15Salivary secretion_Homo sapiens_hsa049702.18270898
16Gastric acid secretion_Homo sapiens_hsa049712.14100510
17Synaptic vesicle cycle_Homo sapiens_hsa047212.07990493
18Cocaine addiction_Homo sapiens_hsa050301.98479282
19Circadian entrainment_Homo sapiens_hsa047131.89769712
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88218737
21Insulin secretion_Homo sapiens_hsa049111.82787014
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.81955703
23Glutamatergic synapse_Homo sapiens_hsa047241.78132429
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.75629633
25Taste transduction_Homo sapiens_hsa047421.74220971
26Dilated cardiomyopathy_Homo sapiens_hsa054141.72755313
27GABAergic synapse_Homo sapiens_hsa047271.72094984
28Morphine addiction_Homo sapiens_hsa050321.71624665
29Ether lipid metabolism_Homo sapiens_hsa005651.70723758
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.66318437
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60121136
32Gap junction_Homo sapiens_hsa045401.58748682
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.50429106
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47151907
35GnRH signaling pathway_Homo sapiens_hsa049121.44560294
36Amphetamine addiction_Homo sapiens_hsa050311.43306335
37Melanogenesis_Homo sapiens_hsa049161.37809074
38Arachidonic acid metabolism_Homo sapiens_hsa005901.36497329
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29455845
40Oxytocin signaling pathway_Homo sapiens_hsa049211.22198275
41Platelet activation_Homo sapiens_hsa046111.21336571
42Cholinergic synapse_Homo sapiens_hsa047251.16600135
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15727332
44Estrogen signaling pathway_Homo sapiens_hsa049151.11514811
45Calcium signaling pathway_Homo sapiens_hsa040201.09369326
46Circadian rhythm_Homo sapiens_hsa047100.97715137
47Dorso-ventral axis formation_Homo sapiens_hsa043200.87319438
48Serotonergic synapse_Homo sapiens_hsa047260.83071508
49Pyruvate metabolism_Homo sapiens_hsa006200.82421231
50Chemokine signaling pathway_Homo sapiens_hsa040620.75082562
51ECM-receptor interaction_Homo sapiens_hsa045120.74986454
52Oocyte meiosis_Homo sapiens_hsa041140.73071018
53Rheumatoid arthritis_Homo sapiens_hsa053230.70406723
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67292031
55RNA degradation_Homo sapiens_hsa030180.53613047
56cAMP signaling pathway_Homo sapiens_hsa040240.47807476
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47226462
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.44499278
59Primary immunodeficiency_Homo sapiens_hsa053400.43276300
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42196549
61Alcoholism_Homo sapiens_hsa050340.40296889
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.35820573
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34643974
64Staphylococcus aureus infection_Homo sapiens_hsa051500.34067623
65Parkinsons disease_Homo sapiens_hsa050120.34035125
66Dopaminergic synapse_Homo sapiens_hsa047280.33782423
67Prion diseases_Homo sapiens_hsa050200.31708730
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.29263767
69Purine metabolism_Homo sapiens_hsa002300.26317279
70Rap1 signaling pathway_Homo sapiens_hsa040150.24812177
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.23836217
72Retinol metabolism_Homo sapiens_hsa008300.20898009
73Hedgehog signaling pathway_Homo sapiens_hsa043400.20862805
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.20506426
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17676128
76Oxidative phosphorylation_Homo sapiens_hsa001900.16158990
77Type I diabetes mellitus_Homo sapiens_hsa049400.15857230
78Phagosome_Homo sapiens_hsa041450.15011642
79Glucagon signaling pathway_Homo sapiens_hsa049220.14558472
80Tuberculosis_Homo sapiens_hsa051520.14239518
81Systemic lupus erythematosus_Homo sapiens_hsa053220.14072502
82Ras signaling pathway_Homo sapiens_hsa040140.13972400
83Caffeine metabolism_Homo sapiens_hsa002320.13797875
84HTLV-I infection_Homo sapiens_hsa051660.12098718
85African trypanosomiasis_Homo sapiens_hsa051430.10111858
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09696405
87Leishmaniasis_Homo sapiens_hsa051400.09336757
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.08340372
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.07690232
90Hematopoietic cell lineage_Homo sapiens_hsa046400.07047419
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06662865
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05120893
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04927109
94Chemical carcinogenesis_Homo sapiens_hsa052040.04646497
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.04242577
96Nicotine addiction_Homo sapiens_hsa050330.04148121
97Renin secretion_Homo sapiens_hsa049240.04066453
98Amoebiasis_Homo sapiens_hsa051460.00705735
99Asthma_Homo sapiens_hsa053100.00556314
100Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0006157

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