OR2T3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adult feeding behavior (GO:0008343)9.85605710
2adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)8.65146992
3regulation of acrosome reaction (GO:0060046)8.40445598
4regulation of protein glycosylation (GO:0060049)8.33905914
5sphingosine metabolic process (GO:0006670)7.60569936
6positive regulation of cAMP-mediated signaling (GO:0043950)7.46290953
7negative regulation of nitric oxide biosynthetic process (GO:0045019)7.14641713
8diol metabolic process (GO:0034311)6.87336659
9piRNA metabolic process (GO:0034587)6.71336107
10thrombin receptor signaling pathway (GO:0070493)6.50009250
11sphingoid metabolic process (GO:0046519)6.48161383
12negative regulation of glycoprotein biosynthetic process (GO:0010561)6.28127382
13glycerol ether metabolic process (GO:0006662)6.11733665
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.87779880
15notochord development (GO:0030903)5.79116622
16signal complex assembly (GO:0007172)5.78817974
17ether metabolic process (GO:0018904)5.64308710
18regulation of glutamate receptor signaling pathway (GO:1900449)5.49643082
19mRNA cleavage (GO:0006379)5.43484156
20DNA replication-dependent nucleosome assembly (GO:0006335)5.35948791
21DNA replication-dependent nucleosome organization (GO:0034723)5.35948791
22cellular response to ammonium ion (GO:0071242)5.10749793
23regulation of cAMP-mediated signaling (GO:0043949)4.78901090
24ncRNA catabolic process (GO:0034661)4.70464306
25pyrimidine dimer repair (GO:0006290)4.57471592
26negative regulation of glycoprotein metabolic process (GO:1903019)4.56632998
27cellular response to alkaloid (GO:0071312)4.23495491
28glomerular visceral epithelial cell development (GO:0072015)4.17762743
29regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.08140008
30negative regulation of cell-matrix adhesion (GO:0001953)4.04587715
31negative regulation of adenylate cyclase activity (GO:0007194)3.98555610
32N-terminal protein amino acid acetylation (GO:0006474)3.86063495
33coenzyme catabolic process (GO:0009109)3.83682168
34negative regulation of cyclase activity (GO:0031280)3.78641096
35negative regulation of exocytosis (GO:0045920)3.75865931
36regulation of translational elongation (GO:0006448)3.70493302
37glomerular epithelial cell development (GO:0072310)3.63534951
38negative regulation of lyase activity (GO:0051350)3.60320523
39regulation of female receptivity (GO:0045924)3.59859498
40response to morphine (GO:0043278)3.54504140
41glycosphingolipid metabolic process (GO:0006687)3.52259929
42vitamin catabolic process (GO:0009111)3.50816550
43fat-soluble vitamin catabolic process (GO:0042363)3.50816550
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.39139645
45response to isoquinoline alkaloid (GO:0014072)3.37974579
46cornea development in camera-type eye (GO:0061303)3.28404870
47regulation of glycoprotein biosynthetic process (GO:0010559)3.27156562
48female mating behavior (GO:0060180)3.25513318
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25037536
50DNA synthesis involved in DNA repair (GO:0000731)3.20627084
51cell-cell junction maintenance (GO:0045217)3.19087669
52positive regulation of nitric oxide biosynthetic process (GO:0045429)3.12589384
53signal peptide processing (GO:0006465)3.11870651
54chemical homeostasis within a tissue (GO:0048875)3.08391160
55omega-hydroxylase P450 pathway (GO:0097267)3.06764014
56membrane depolarization during action potential (GO:0086010)3.06294059
57regulation of odontogenesis (GO:0042481)3.05470910
58negative regulation of calcium ion transport into cytosol (GO:0010523)3.05293939
59thyroid hormone generation (GO:0006590)2.99790513
60regulation of memory T cell differentiation (GO:0043380)2.98214360
61positive regulation of icosanoid secretion (GO:0032305)2.95219505
62positive regulation of fatty acid transport (GO:2000193)2.94604233
63dopamine receptor signaling pathway (GO:0007212)2.90806855
64glomerular basement membrane development (GO:0032836)2.89458064
65smooth muscle tissue development (GO:0048745)2.87145566
66positive regulation of cardiac muscle cell differentiation (GO:2000727)2.86615856
67striated muscle atrophy (GO:0014891)2.86107575
68histone H3-K9 modification (GO:0061647)2.85190970
69neuronal action potential (GO:0019228)2.80761495
70wound healing, spreading of epidermal cells (GO:0035313)2.79607480
71thyroid hormone metabolic process (GO:0042403)2.78064458
72glycolipid metabolic process (GO:0006664)2.77512090
73detection of mechanical stimulus (GO:0050982)2.76966380
74regulation of calcium ion-dependent exocytosis (GO:0017158)2.76824238
75positive regulation of T-helper 1 type immune response (GO:0002827)2.75589637
76negative regulation of cAMP biosynthetic process (GO:0030818)2.73824697
77membrane lipid metabolic process (GO:0006643)2.73611231
78replication fork processing (GO:0031297)2.69368085
79response to caffeine (GO:0031000)2.66176809
80positive regulation of protein complex disassembly (GO:0043243)2.65639289
81left/right axis specification (GO:0070986)2.64894783
82cellular response to ATP (GO:0071318)2.64488974
83surfactant homeostasis (GO:0043129)2.62928453
84negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.62786653
85gene silencing by RNA (GO:0031047)2.62074509
86positive regulation of cholesterol efflux (GO:0010875)2.61481398
87sensory perception of pain (GO:0019233)2.59112626
88regulation of cytokine production involved in inflammatory response (GO:1900015)2.58834471
89liposaccharide metabolic process (GO:1903509)2.57489117
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57020281
91positive regulation of T-helper cell differentiation (GO:0045624)2.57007361
92indolalkylamine metabolic process (GO:0006586)2.55947295
93polyol biosynthetic process (GO:0046173)2.55856837
94negative regulation of cytosolic calcium ion concentration (GO:0051481)15.6228514
95negative regulation of cAMP-mediated signaling (GO:0043951)13.0503372
96opioid receptor signaling pathway (GO:0038003)11.5922350
97regulation of translational termination (GO:0006449)10.9874013
98ether lipid metabolic process (GO:0046485)10.7965766
99behavioral response to ethanol (GO:0048149)10.4060429
100negative regulation of calcium ion-dependent exocytosis (GO:0045955)10.3779730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.69641747
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.30040110
3VDR_22108803_ChIP-Seq_LS180_Human3.32634751
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.32473888
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse3.07968732
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.07968732
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92705937
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80606642
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79795148
10RXR_22108803_ChIP-Seq_LS180_Human2.72456936
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.59751803
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38702824
13TAF15_26573619_Chip-Seq_HEK293_Human2.34984069
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34509777
15EGR1_19032775_ChIP-ChIP_M12_Human2.30222491
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.24984019
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.21452155
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16479760
19GBX2_23144817_ChIP-Seq_PC3_Human2.05351570
20SUZ12_27294783_Chip-Seq_NPCs_Mouse1.97550705
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83338051
22BCAT_22108803_ChIP-Seq_LS180_Human1.82384379
23NANOG_19829295_ChIP-Seq_ESCs_Human1.78644424
24SOX2_19829295_ChIP-Seq_ESCs_Human1.78644424
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.76831112
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74625217
27CBP_20019798_ChIP-Seq_JUKART_Human1.74625217
28STAT3_23295773_ChIP-Seq_U87_Human1.70905720
29HTT_18923047_ChIP-ChIP_STHdh_Human1.70119929
30ZNF274_21170338_ChIP-Seq_K562_Hela1.69893135
31TCF4_23295773_ChIP-Seq_U87_Human1.68641352
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63471379
33IRF1_19129219_ChIP-ChIP_H3396_Human1.63099363
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53191572
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47733990
36DROSHA_22980978_ChIP-Seq_HELA_Human1.45055680
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44400933
38RUNX_20019798_ChIP-Seq_JUKART_Human1.44167408
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43571062
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.41979826
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40582219
42SCL_19346495_ChIP-Seq_HPC-7_Human1.38663730
43CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38442257
44TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34837352
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30517179
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.29317929
47TP53_16413492_ChIP-PET_HCT116_Human1.26240353
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24259921
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.23268387
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22811082
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.22454356
52NANOG_20526341_ChIP-Seq_ESCs_Human1.21968670
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21311189
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.20947921
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20509509
56SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20269112
57CDX2_22108803_ChIP-Seq_LS180_Human1.20217734
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18904969
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18416211
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17238226
61TP53_18474530_ChIP-ChIP_U2OS_Human1.17089827
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14759346
63KDM2B_26808549_Chip-Seq_REH_Human1.14287122
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13760762
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.11849228
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11503389
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11220411
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09700541
69AR_21572438_ChIP-Seq_LNCaP_Human1.08303638
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.08200946
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07332955
72RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05015344
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.04746019
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.04356507
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04246100
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04181818
77AR_25329375_ChIP-Seq_VCAP_Human1.03784531
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03053315
79SMAD4_21799915_ChIP-Seq_A2780_Human1.02785946
80P300_19829295_ChIP-Seq_ESCs_Human1.02426374
81CEBPB_22108803_ChIP-Seq_LS180_Human1.02311278
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01499663
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01051546
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00686220
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00680346
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99179274
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.97825177
88SMRT_27268052_Chip-Seq_Bcells_Human0.97782977
89IGF1R_20145208_ChIP-Seq_DFB_Human0.97334204
90ER_23166858_ChIP-Seq_MCF-7_Human0.96984063
91PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96685585
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.95654854
93TCF4_22108803_ChIP-Seq_LS180_Human0.94980065
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94160936
95* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93014782
96IRF8_21731497_ChIP-ChIP_J774_Mouse0.92152383
97TP63_23658742_ChIP-Seq_EP156T_Human0.91668534
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.90297709
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.89868320
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.89807763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow6.81913733
2MP0009780_abnormal_chondrocyte_physiolo5.98423248
3MP0002876_abnormal_thyroid_physiology5.51299020
4MP0005360_urolithiasis4.43082934
5MP0005503_abnormal_tendon_morphology3.98245038
6MP0001968_abnormal_touch/_nociception3.86884844
7MP0000678_abnormal_parathyroid_gland3.12165267
8MP0003045_fibrosis3.06078308
9MP0003941_abnormal_skin_development3.02622870
10MP0009764_decreased_sensitivity_to2.78435064
11MP0001545_abnormal_hematopoietic_system2.64319939
12MP0005397_hematopoietic_system_phenotyp2.64319939
13MP0003880_abnormal_central_pattern2.59493916
14MP0003183_abnormal_peptide_metabolism2.45334700
15MP0008057_abnormal_DNA_replication2.44961536
16MP0000681_abnormal_thyroid_gland2.41419453
17MP0006035_abnormal_mitochondrial_morpho2.36490073
18MP0009333_abnormal_splenocyte_physiolog2.28994319
19MP0001501_abnormal_sleep_pattern2.24011663
20MP0005551_abnormal_eye_electrophysiolog1.97456516
21MP0005645_abnormal_hypothalamus_physiol1.94706410
22MP0005646_abnormal_pituitary_gland1.88742925
23MP0003950_abnormal_plasma_membrane1.86692227
24MP0001664_abnormal_digestion1.82201036
25MP0003633_abnormal_nervous_system1.79134838
26MP0010234_abnormal_vibrissa_follicle1.63768874
27MP0003646_muscle_fatigue1.54137721
28MP0003191_abnormal_cellular_cholesterol1.52186551
29MP0005310_abnormal_salivary_gland1.45906276
30MP0002249_abnormal_larynx_morphology1.45888089
31MP0003195_calcinosis1.45263447
32MP0003879_abnormal_hair_cell1.40719556
33MP0002796_impaired_skin_barrier1.37689528
34MP0002168_other_aberrant_phenotype1.35229191
35MP0005167_abnormal_blood-brain_barrier1.33613179
36MP0002733_abnormal_thermal_nociception1.32903850
37MP0009046_muscle_twitch1.32289595
38MP0000015_abnormal_ear_pigmentation1.30866487
39MP0003959_abnormal_lean_body1.30827842
40MP0003638_abnormal_response/metabolism_1.27442775
41MP0004782_abnormal_surfactant_physiolog1.14566481
42MP0009745_abnormal_behavioral_response1.14114932
43MP0000569_abnormal_digit_pigmentation1.12069266
44MP0002971_abnormal_brown_adipose1.10065772
45MP0000685_abnormal_immune_system1.09324249
46MP0004858_abnormal_nervous_system1.09166558
47MP0009765_abnormal_xenobiotic_induced1.07509542
48MP0001881_abnormal_mammary_gland1.05096374
49MP0003868_abnormal_feces_composition1.03938783
50MP0000749_muscle_degeneration1.02376717
51MP0002272_abnormal_nervous_system1.01224842
52MP0003631_nervous_system_phenotype1.01022402
53MP0002693_abnormal_pancreas_physiology0.98016104
54MP0008874_decreased_physiological_sensi0.93510859
55MP0002148_abnormal_hypersensitivity_rea0.92713201
56MP0008872_abnormal_physiological_respon0.87664380
57MP0003567_abnormal_fetal_cardiomyocyte0.85475610
58MP0010678_abnormal_skin_adnexa0.83631383
59MP0000230_abnormal_systemic_arterial0.82936467
60MP0010771_integument_phenotype0.80767578
61MP0008775_abnormal_heart_ventricle0.78904238
62MP0005501_abnormal_skin_physiology0.76155986
63MP0001970_abnormal_pain_threshold0.76068037
64MP0000358_abnormal_cell_content/0.76057825
65MP0002229_neurodegeneration0.73822466
66MP0005334_abnormal_fat_pad0.73285532
67MP0001486_abnormal_startle_reflex0.71029832
68MP0001270_distended_abdomen0.69984257
69MP0002108_abnormal_muscle_morphology0.69943278
70MP0005395_other_phenotype0.69432207
71MP0006054_spinal_hemorrhage0.67132085
72MP0004264_abnormal_extraembryonic_tissu0.63820038
73MP0004130_abnormal_muscle_cell0.62746664
74MP0004147_increased_porphyrin_level0.61105757
75MP0001986_abnormal_taste_sensitivity0.60680195
76MP0000383_abnormal_hair_follicle0.58801330
77MP0001919_abnormal_reproductive_system0.57639033
78MP0004859_abnormal_synaptic_plasticity0.56747892
79MP0005670_abnormal_white_adipose0.55618147
80MP0003763_abnormal_thymus_physiology0.55171444
81MP0005195_abnormal_posterior_eye0.54666738
82MP0009672_abnormal_birth_weight0.53844106
83MP0002067_abnormal_sensory_capabilities0.52880192
84MP0003937_abnormal_limbs/digits/tail_de0.51816876
85MP0000427_abnormal_hair_cycle0.46949274
86MP0002095_abnormal_skin_pigmentation0.46079254
87MP0001324_abnormal_eye_pigmentation0.45922060
88MP0005387_immune_system_phenotype0.45739920
89MP0001790_abnormal_immune_system0.45739920
90MP0005671_abnormal_response_to0.44968082
91MP0004381_abnormal_hair_follicle0.44876474
92MP0003635_abnormal_synaptic_transmissio0.44252510
93MP0004043_abnormal_pH_regulation0.42264804
94MP0002069_abnormal_eating/drinking_beha0.40787841
95MP0003091_abnormal_cell_migration0.39751631
96MP0009384_cardiac_valve_regurgitation0.39585460
97MP0005452_abnormal_adipose_tissue0.39436389
98MP0002998_abnormal_bone_remodeling0.39393038
99MP0009643_abnormal_urine_homeostasis0.38639129
100MP0003936_abnormal_reproductive_system0.37566108

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)7.00142262
2Intestinal atresia (HP:0011100)6.73982937
3Pancreatic islet-cell hyperplasia (HP:0004510)6.45843168
4Abnormality of the aortic arch (HP:0012303)6.12614055
5Broad alveolar ridges (HP:0000187)5.42984817
6Large for gestational age (HP:0001520)5.36939456
7Thickened helices (HP:0000391)5.26456738
8Oligodontia (HP:0000677)4.84976398
9Poor head control (HP:0002421)4.84738436
10Gaze-evoked nystagmus (HP:0000640)4.32074322
11Abnormality of endocrine pancreas physiology (HP:0012093)4.26244884
12Abnormality of the pancreatic islet cells (HP:0006476)4.26244884
13Mesangial abnormality (HP:0001966)4.09394806
14Agitation (HP:0000713)3.99022969
15Congenital ichthyosiform erythroderma (HP:0007431)3.98282763
16Focal motor seizures (HP:0011153)3.92071183
17Tented upper lip vermilion (HP:0010804)3.82045322
18Abnormality of the ileum (HP:0001549)3.81853259
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66603052
20Large eyes (HP:0001090)3.34559989
21Tubular atrophy (HP:0000092)3.33244795
22Progressive inability to walk (HP:0002505)3.30265572
23Myositis (HP:0100614)3.28873374
24Chromsome breakage (HP:0040012)3.24824091
25Gastrointestinal atresia (HP:0002589)3.23312672
26Increased corneal curvature (HP:0100692)3.04896850
27Keratoconus (HP:0000563)3.04896850
28Hypoproteinemia (HP:0003075)3.00975345
29Orchitis (HP:0100796)2.98435199
30Poor speech (HP:0002465)2.97831637
31Nephroblastoma (Wilms tumor) (HP:0002667)2.89801674
32Abnormality of the alveolar ridges (HP:0006477)2.85777568
33Pili torti (HP:0003777)2.82489161
34Hyperpituitarism (HP:0010514)2.77549076
35Embryonal renal neoplasm (HP:0011794)2.73350024
36Cerebellar dysplasia (HP:0007033)2.67214791
37Autoimmune hemolytic anemia (HP:0001890)2.66918376
38Hypoplasia of the brainstem (HP:0002365)2.64595472
39Aplasia/Hypoplasia of the brainstem (HP:0007362)2.64595472
40Ectropion (HP:0000656)2.57345506
41Type II lissencephaly (HP:0007260)2.53142544
42Neonatal respiratory distress (HP:0002643)2.47191649
43Hyperthyroidism (HP:0000836)2.46060777
44Abnormal hair laboratory examination (HP:0003328)2.43403750
45Broad-based gait (HP:0002136)2.41222715
46Dialeptic seizures (HP:0011146)2.39875497
47Entropion (HP:0000621)2.39109734
48Long nose (HP:0003189)2.34495452
49Optic nerve hypoplasia (HP:0000609)2.28946078
50Poikiloderma (HP:0001029)2.26101109
51Elevated erythrocyte sedimentation rate (HP:0003565)2.24304913
52Hypoplasia of the pons (HP:0012110)2.23031901
53Nonprogressive disorder (HP:0003680)2.22340713
54Dysdiadochokinesis (HP:0002075)2.20957548
55Focal seizures (HP:0007359)2.17812519
56Central scotoma (HP:0000603)2.17696287
57Lissencephaly (HP:0001339)2.15147724
58Goiter (HP:0000853)2.14377562
59Striae distensae (HP:0001065)2.09816235
60Abnormality of macular pigmentation (HP:0008002)2.06049387
61Impulsivity (HP:0100710)2.05241004
62Ileus (HP:0002595)2.03238068
63High anterior hairline (HP:0009890)2.01334908
64Amelogenesis imperfecta (HP:0000705)2.00619682
65Thyroid-stimulating hormone excess (HP:0002925)14.3120161
66Hydroxyprolinuria (HP:0003080)1.97307489
67Abnormality of proline metabolism (HP:0010907)1.97307489
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97129220
69Abnormality of the pons (HP:0007361)1.96731533
70Restlessness (HP:0000711)1.94192181
71Generalized tonic-clonic seizures (HP:0002069)1.91614775
72Hypohidrosis (HP:0000966)1.90567066
73Abnormality of nail color (HP:0100643)1.89571501
74Attenuation of retinal blood vessels (HP:0007843)1.86074863
75Scotoma (HP:0000575)1.85145733
76Inability to walk (HP:0002540)1.84826499
77Muscular dystrophy (HP:0003560)1.79714888
78Pendular nystagmus (HP:0012043)1.79006877
79Facial diplegia (HP:0001349)1.78404570
80Retrobulbar optic neuritis (HP:0100654)1.77014866
81Optic neuritis (HP:0100653)1.77014866
82Abnormal delayed hypersensitivity skin test (HP:0002963)1.76613276
83Abnormality of the vitreous humor (HP:0004327)1.76039565
84Hamartoma (HP:0010566)1.75918106
85Mediastinal lymphadenopathy (HP:0100721)1.75890159
86Abnormality of the columella (HP:0009929)1.73780484
87Congenital stationary night blindness (HP:0007642)1.68443050
88Lack of skin elasticity (HP:0100679)1.67226793
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66716277
90Non-midline cleft lip (HP:0100335)1.65921371
91Testicular neoplasm (HP:0010788)1.65916571
92Hypercortisolism (HP:0001578)1.65249755
93Pigmentary retinal degeneration (HP:0001146)1.63652972
94Cutaneous melanoma (HP:0012056)1.62167741
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.62062985
96Duplicated collecting system (HP:0000081)1.60535005
97Increased neuronal autofluorescent lipopigment (HP:0002074)1.60423535
98Clubbing of toes (HP:0100760)1.59767520
99Peritonitis (HP:0002586)1.58179870
100Keratitis (HP:0000491)1.57853578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.38331222
2ERN14.96309583
3PINK13.23735215
4IRAK32.98347985
5PDK22.96060787
6ADRBK12.57452530
7ACVR1B2.18064600
8ADRBK210.5509110
9TGFBR11.83357354
10IRAK11.82625740
11MAPK111.79544480
12PRKCG1.76162434
13BMPR1B1.74626545
14PNCK1.72329290
15TYRO31.59117229
16PRKCE1.43738868
17DYRK31.16905526
18MELK1.12762493
19CLK11.12479226
20NEK91.12327785
21EIF2AK31.11651971
22PKN21.11591042
23GRK11.07676205
24PLK21.04014340
25RIPK10.95866644
26ERBB40.91811718
27MAPKAPK50.89865384
28NEK10.77416957
29PTK2B0.76962159
30CAMK1G0.74148106
31CDC42BPA0.71284212
32CAMK2A0.70442004
33PRKCI0.67713214
34BLK0.66943411
35STK38L0.66698953
36MKNK10.63908784
37TAOK30.61821872
38TEC0.60837361
39MAPK130.57219188
40NME10.56943484
41PDK10.55229358
42SGK10.53577768
43OXSR10.49740356
44MAPK70.49670786
45NTRK20.49650304
46FLT30.48287258
47STK380.48136483
48NEK20.46503832
49STK30.46152271
50ERBB20.45818543
51OBSCN0.45556489
52MKNK20.43678199
53GRK50.42927865
54CAMK10.41929955
55PRKCB0.41174863
56NEK60.39429091
57MAPK10.38915356
58BRSK10.35437688
59CAMK40.34676188
60GRK70.34649342
61PDPK10.31019848
62PRKCH0.30961880
63PRKCA0.30945834
64IKBKB0.30279139
65ITK0.29012437
66MAPK30.28384273
67AKT10.28293902
68MAPK40.27082476
69TRPM70.26962637
70INSRR0.26707654
71DYRK1A0.26469999
72RPS6KA30.26432792
73CSF1R0.25705363
74MAPK120.25398334
75STK390.24613216
76ABL10.23779496
77EEF2K0.22145243
78TXK0.22110540
79SYK0.21815550
80ATR0.20320836
81EIF2AK20.19073416
82SIK20.19051913
83ATM0.18310986
84MAP2K20.17869172
85CSNK1E0.17528649
86MAPKAPK30.17113181
87PIK3CG0.17062636
88CSNK2A20.16545033
89PRKACG0.16394488
90WEE10.16102565
91KIT0.15556204
92GSK3B0.13964992
93CHUK0.13649804
94PRKACA0.13428635
95PRKDC0.12878892
96MST40.11923634
97MARK30.11442093
98CSNK1A10.10461837
99MAP3K70.10404562
100BTK0.09933045

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043204.38673483
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.79763938
3ABC transporters_Homo sapiens_hsa020103.10182050
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.96800507
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.93129163
6Sphingolipid metabolism_Homo sapiens_hsa006002.71194390
7Phototransduction_Homo sapiens_hsa047442.55925243
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41339803
9Fanconi anemia pathway_Homo sapiens_hsa034602.35124079
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.31924313
11Morphine addiction_Homo sapiens_hsa050322.30188076
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23683679
13Glycerolipid metabolism_Homo sapiens_hsa005612.20629008
14Pentose phosphate pathway_Homo sapiens_hsa000302.03845000
15Ovarian steroidogenesis_Homo sapiens_hsa049131.97687546
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.83006859
17Butanoate metabolism_Homo sapiens_hsa006501.76793140
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.74524669
19Taste transduction_Homo sapiens_hsa047421.67959749
20Linoleic acid metabolism_Homo sapiens_hsa005911.62632963
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60003103
22Tryptophan metabolism_Homo sapiens_hsa003801.52879219
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47433214
24Complement and coagulation cascades_Homo sapiens_hsa046101.43272128
25Homologous recombination_Homo sapiens_hsa034401.36592238
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35573644
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31970144
28Arachidonic acid metabolism_Homo sapiens_hsa005901.28939286
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28861764
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27708786
31Graft-versus-host disease_Homo sapiens_hsa053321.22660475
32Estrogen signaling pathway_Homo sapiens_hsa049151.19281600
33Starch and sucrose metabolism_Homo sapiens_hsa005001.17728891
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15414936
35Sulfur relay system_Homo sapiens_hsa041221.13005628
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12411826
37Fatty acid degradation_Homo sapiens_hsa000711.05716265
38Primary immunodeficiency_Homo sapiens_hsa053401.04336743
39* Olfactory transduction_Homo sapiens_hsa047401.03718338
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02083551
41Basal transcription factors_Homo sapiens_hsa030221.01753129
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.97507163
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96824119
44Calcium signaling pathway_Homo sapiens_hsa040200.95294940
45One carbon pool by folate_Homo sapiens_hsa006700.94886124
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94678658
47Nitrogen metabolism_Homo sapiens_hsa009100.92995488
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90673143
49Retinol metabolism_Homo sapiens_hsa008300.87593167
50Ether lipid metabolism_Homo sapiens_hsa005650.86325025
51Allograft rejection_Homo sapiens_hsa053300.86278740
52Mineral absorption_Homo sapiens_hsa049780.83844622
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82823790
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.80264474
55Autoimmune thyroid disease_Homo sapiens_hsa053200.79495754
56Salivary secretion_Homo sapiens_hsa049700.71587997
57Caffeine metabolism_Homo sapiens_hsa002320.70425289
58Glutamatergic synapse_Homo sapiens_hsa047240.70248404
59Asthma_Homo sapiens_hsa053100.68230598
60MicroRNAs in cancer_Homo sapiens_hsa052060.67721340
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66114499
62Renin-angiotensin system_Homo sapiens_hsa046140.65417110
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59001164
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.57621463
65Chemical carcinogenesis_Homo sapiens_hsa052040.56871707
66mRNA surveillance pathway_Homo sapiens_hsa030150.56636521
67Propanoate metabolism_Homo sapiens_hsa006400.55767185
68Pancreatic secretion_Homo sapiens_hsa049720.53534871
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51549023
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50964405
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50645260
72Histidine metabolism_Homo sapiens_hsa003400.50305409
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49530341
74Staphylococcus aureus infection_Homo sapiens_hsa051500.48134668
75Purine metabolism_Homo sapiens_hsa002300.43412659
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.42512465
77Metabolic pathways_Homo sapiens_hsa011000.41468425
78Legionellosis_Homo sapiens_hsa051340.40181048
79RNA degradation_Homo sapiens_hsa030180.39180544
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38711922
81beta-Alanine metabolism_Homo sapiens_hsa004100.38058128
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.37162521
83Type I diabetes mellitus_Homo sapiens_hsa049400.36526130
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.36405587
85Arginine biosynthesis_Homo sapiens_hsa002200.34358960
86ECM-receptor interaction_Homo sapiens_hsa045120.33192627
87Serotonergic synapse_Homo sapiens_hsa047260.30286328
88Lysosome_Homo sapiens_hsa041420.27715454
89T cell receptor signaling pathway_Homo sapiens_hsa046600.25562288
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25400354
91Long-term depression_Homo sapiens_hsa047300.24438165
92Hedgehog signaling pathway_Homo sapiens_hsa043400.23891640
93Circadian entrainment_Homo sapiens_hsa047130.23278098
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23057467
95Oxytocin signaling pathway_Homo sapiens_hsa049210.22389438
96Peroxisome_Homo sapiens_hsa041460.22077800
97Fatty acid biosynthesis_Homo sapiens_hsa000610.21900298
98Apoptosis_Homo sapiens_hsa042100.21560186
99Glucagon signaling pathway_Homo sapiens_hsa049220.19893243
100Glutathione metabolism_Homo sapiens_hsa004800.19849887

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