OR1F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.31182714
2spermatid nucleus differentiation (GO:0007289)8.78899006
3chromosome condensation (GO:0030261)8.71144616
4microtubule depolymerization (GO:0007019)8.49053261
5sperm capacitation (GO:0048240)8.29979735
6DNA packaging (GO:0006323)8.26061094
7plasma membrane fusion (GO:0045026)7.73110613
8single strand break repair (GO:0000012)7.10398246
9microtubule polymerization or depolymerization (GO:0031109)7.02764110
10sperm-egg recognition (GO:0035036)6.87129896
11spermatid development (GO:0007286)6.54701845
12binding of sperm to zona pellucida (GO:0007339)6.53110978
13protein targeting to Golgi (GO:0000042)6.24031457
14calcium ion-dependent exocytosis (GO:0017156)6.12334706
15protein polyglutamylation (GO:0018095)6.05967274
16sexual reproduction (GO:0019953)5.96055798
17establishment of protein localization to Golgi (GO:0072600)5.92653344
18rRNA methylation (GO:0031167)5.92119383
19multicellular organism reproduction (GO:0032504)5.88855328
20retrograde transport, vesicle recycling within Golgi (GO:0000301)5.71338761
21reproduction (GO:0000003)5.70190852
22spermatogenesis (GO:0007283)5.59422626
23male gamete generation (GO:0048232)5.57256332
24axonemal dynein complex assembly (GO:0070286)5.56532875
25cell-cell recognition (GO:0009988)5.49580945
26centriole replication (GO:0007099)5.42512777
27rRNA modification (GO:0000154)5.26327592
28regulation of centriole replication (GO:0046599)5.18631559
29gamete generation (GO:0007276)5.08935495
30negative regulation of inclusion body assembly (GO:0090084)5.01921519
31phosphatidylethanolamine biosynthetic process (GO:0006646)4.99451371
32positive regulation of Rab GTPase activity (GO:0032851)4.87748180
33regulation of Rab GTPase activity (GO:0032313)4.87748180
34phosphatidylethanolamine metabolic process (GO:0046337)4.84189462
35microtubule severing (GO:0051013)4.78526282
36centriole assembly (GO:0098534)4.62997126
37regulation of transcription involved in cell fate commitment (GO:0060850)4.51552749
38regulation of cilium movement (GO:0003352)4.46021614
39seminiferous tubule development (GO:0072520)4.43261665
40single fertilization (GO:0007338)4.41698974
41protein localization to Golgi apparatus (GO:0034067)4.32010630
42cellular ketone body metabolic process (GO:0046950)4.30935203
43motile cilium assembly (GO:0044458)4.29891880
44chromatin silencing (GO:0006342)4.14240811
45multicellular organismal reproductive process (GO:0048609)4.04791143
46microtubule nucleation (GO:0007020)4.04083287
47nucleus organization (GO:0006997)3.89472792
48ketone body metabolic process (GO:1902224)3.80297507
49cilium or flagellum-dependent cell motility (GO:0001539)3.79430091
50germ cell development (GO:0007281)3.79264004
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78247067
52cellular process involved in reproduction in multicellular organism (GO:0022412)3.77792816
53regulation of inclusion body assembly (GO:0090083)3.72642083
54fertilization (GO:0009566)3.72583130
55Golgi to endosome transport (GO:0006895)3.68649137
56glycerol ether metabolic process (GO:0006662)3.64991391
57protein depolymerization (GO:0051261)3.64249157
58coenzyme catabolic process (GO:0009109)3.62976162
59nucleosome disassembly (GO:0006337)3.56257124
60protein-DNA complex disassembly (GO:0032986)3.56257124
61cerebral cortex neuron differentiation (GO:0021895)3.56076126
62regulation of T-helper 2 cell differentiation (GO:0045628)3.39735712
63ether metabolic process (GO:0018904)3.35231304
64epithelial cilium movement (GO:0003351)3.27992150
65musculoskeletal movement (GO:0050881)3.22577763
66multicellular organismal movement (GO:0050879)3.22577763
67RNA destabilization (GO:0050779)3.22055717
68cell wall macromolecule metabolic process (GO:0044036)3.18012912
69auditory behavior (GO:0031223)3.15550443
70regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.14230108
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14115254
72negative regulation of Rho protein signal transduction (GO:0035024)3.13468662
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.11733045
74regulation of interleukin-13 production (GO:0032656)3.06323992
75cell-cell junction maintenance (GO:0045217)3.01013259
76mesenchymal cell differentiation involved in renal system development (GO:2001012)2.99322998
77mesenchymal cell differentiation involved in kidney development (GO:0072161)2.99322998
78cell wall macromolecule catabolic process (GO:0016998)2.98988464
79receptor recycling (GO:0001881)2.95766229
80glomerular visceral epithelial cell development (GO:0072015)2.94057416
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91001275
82negative regulation of gene expression, epigenetic (GO:0045814)2.86295963
83DNA conformation change (GO:0071103)2.82303279
84organic cation transport (GO:0015695)2.81935684
85cilium movement (GO:0003341)2.81112029
86nuclear pore complex assembly (GO:0051292)2.80321532
87regulation of ARF GTPase activity (GO:0032312)2.79772506
88glomerular epithelial cell development (GO:0072310)2.77438250
89regulation of protein kinase A signaling (GO:0010738)2.77196062
90vesicle transport along microtubule (GO:0047496)2.76337894
91response to acidic pH (GO:0010447)2.76085148
92cell recognition (GO:0008037)2.74191981
93histone H3-K9 demethylation (GO:0033169)2.72958868
94cellular response to pH (GO:0071467)2.71322227
95regulation of microtubule-based movement (GO:0060632)2.65011187
96polyamine biosynthetic process (GO:0006596)2.61763284
97polarized epithelial cell differentiation (GO:0030859)2.60229312
98acrosome reaction (GO:0007340)10.5332591
99sperm motility (GO:0030317)10.2271476
100fusion of sperm to egg plasma membrane (GO:0007342)10.1800598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.59470640
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.77394004
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92709721
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.67239914
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.59522531
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46590231
7EZH2_22144423_ChIP-Seq_EOC_Human2.23302729
8ELF1_20517297_ChIP-Seq_JURKAT_Human2.17515044
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07040923
10CBP_20019798_ChIP-Seq_JUKART_Human2.05161067
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.05161067
12ERA_21632823_ChIP-Seq_H3396_Human1.99344003
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94142604
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94142604
15EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.90529534
16WDR5_24793694_ChIP-Seq_LNCAP_Human1.90502918
17DROSHA_22980978_ChIP-Seq_HELA_Human1.85552063
18* RAC3_21632823_ChIP-Seq_H3396_Human1.80735885
19FUS_26573619_Chip-Seq_HEK293_Human1.78943482
20SMC4_20622854_ChIP-Seq_HELA_Human1.77008861
21CTCF_27219007_Chip-Seq_Bcells_Human1.76692004
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74778501
23TAF15_26573619_Chip-Seq_HEK293_Human1.73768029
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69101843
25* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.68917251
26* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.66946196
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60121849
28NANOG_20526341_ChIP-Seq_ESCs_Human1.59231936
29MYC_19829295_ChIP-Seq_ESCs_Human1.57089616
30* YY1_22570637_ChIP-Seq_MALME-3M_Human1.55159137
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.53521007
32* PHF8_20622854_ChIP-Seq_HELA_Human1.52185555
33* P68_20966046_ChIP-Seq_HELA_Human1.51978771
34BCL6_27268052_Chip-Seq_Bcells_Human1.51372093
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50969510
36* E2F1_20622854_ChIP-Seq_HELA_Human1.49369073
37* BCOR_27268052_Chip-Seq_Bcells_Human1.47140044
38TAF2_19829295_ChIP-Seq_ESCs_Human1.46251132
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45803318
40* CTCF_20526341_ChIP-Seq_ESCs_Human1.45585853
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45300415
42ER_23166858_ChIP-Seq_MCF-7_Human1.45236946
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.41241978
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40840719
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38968811
46CBX2_22325352_ChIP-Seq_293T-Rex_Human1.38589928
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37309833
48OCT4_20526341_ChIP-Seq_ESCs_Human1.36919340
49SMAD4_21741376_ChIP-Seq_EPCs_Human1.35628234
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35117951
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.34853749
52TP63_22573176_ChIP-Seq_HFKS_Human1.34159401
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33273549
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33002329
55CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30759654
56TP53_18474530_ChIP-ChIP_U2OS_Human1.29713732
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.29642996
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.27969230
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.27226519
60RBPJ_21746931_ChIP-Seq_IB4_Human1.27194669
61LXR_22292898_ChIP-Seq_THP-1_Human1.26716537
62AR_25329375_ChIP-Seq_VCAP_Human1.26526857
63AR_21572438_ChIP-Seq_LNCaP_Human1.26518965
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25616698
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25508621
66ETV1_20927104_ChIP-Seq_GIST48_Human1.25296944
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.23963042
68SMAD3_21741376_ChIP-Seq_ESCs_Human1.23947013
69REST_21632747_ChIP-Seq_MESCs_Mouse1.23097020
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.18172111
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17560252
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17560252
73P300_19829295_ChIP-Seq_ESCs_Human1.16715588
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16518797
75P53_21459846_ChIP-Seq_SAOS-2_Human1.15257253
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14613027
77NFYB_21822215_ChIP-Seq_K562_Human1.14410060
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14386256
79ZNF274_21170338_ChIP-Seq_K562_Hela1.13949826
80OCT4_19829295_ChIP-Seq_ESCs_Human1.13277209
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11687638
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11075133
83TBL1_22424771_ChIP-Seq_293T_Human1.10290022
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10265555
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09186845
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08814323
87RUNX2_22187159_ChIP-Seq_PCA_Human1.08593347
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08251473
89PHF8_20622853_ChIP-Seq_HELA_Human1.07603331
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07509788
91RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07379021
92SA1_27219007_Chip-Seq_Bcells_Human1.04470100
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.03959189
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.03656694
95P300_27268052_Chip-Seq_Bcells_Human1.02262775
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.01678266
97* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01299702
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00192403
99* ERG_20517297_ChIP-Seq_VCAP_Human0.99953467
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99909063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.97357759
2MP0004859_abnormal_synaptic_plasticity4.02861595
3MP0003878_abnormal_ear_physiology4.02513793
4MP0005377_hearing/vestibular/ear_phenot4.02513793
5MP0003698_abnormal_male_reproductive3.85741093
6MP0005670_abnormal_white_adipose3.82162022
7MP0001348_abnormal_lacrimal_gland3.63876179
8MP0005423_abnormal_somatic_nervous3.41738366
9MP0001929_abnormal_gametogenesis3.12841382
10MP0002822_catalepsy2.78626413
11MP0002735_abnormal_chemical_nociception2.61644198
12MP0001529_abnormal_vocalization2.32833488
13MP0002161_abnormal_fertility/fecundity2.22579284
14MP0000678_abnormal_parathyroid_gland2.05854168
15MP0003122_maternal_imprinting1.97100343
16MP0003718_maternal_effect1.84857499
17MP0001486_abnormal_startle_reflex1.78599064
18MP0001905_abnormal_dopamine_level1.77374948
19MP0003880_abnormal_central_pattern1.64394347
20MP0002210_abnormal_sex_determination1.53818535
21MP0002234_abnormal_pharynx_morphology1.52629293
22MP0005379_endocrine/exocrine_gland_phen1.40651005
23MP0003879_abnormal_hair_cell1.38425815
24MP0002282_abnormal_trachea_morphology1.38204579
25MP0001984_abnormal_olfaction1.36918793
26MP0003635_abnormal_synaptic_transmissio1.33773587
27MP0008569_lethality_at_weaning1.29015368
28MP0001968_abnormal_touch/_nociception1.23489966
29MP0002132_abnormal_respiratory_system1.21707050
30MP0001145_abnormal_male_reproductive1.19108612
31MP0002733_abnormal_thermal_nociception1.16494155
32MP0002572_abnormal_emotion/affect_behav1.15927439
33MP0005623_abnormal_meninges_morphology1.13322997
34MP0005451_abnormal_body_composition1.13075422
35MP0000653_abnormal_sex_gland1.12511479
36MP0002249_abnormal_larynx_morphology1.10258249
37MP0000955_abnormal_spinal_cord1.10055568
38MP0004270_analgesia1.09709229
39MP0001485_abnormal_pinna_reflex1.09161512
40MP0000534_abnormal_ureter_morphology1.08932586
41MP0001970_abnormal_pain_threshold1.08625965
42MP0005248_abnormal_Harderian_gland1.08477661
43MP0000026_abnormal_inner_ear1.07729116
44MP0003011_delayed_dark_adaptation1.05650513
45MP0003121_genomic_imprinting1.04848269
46MP0002067_abnormal_sensory_capabilities1.04733973
47MP0009745_abnormal_behavioral_response1.03472057
48MP0002063_abnormal_learning/memory/cond1.03413848
49MP0002734_abnormal_mechanical_nocicepti1.02770447
50MP0002557_abnormal_social/conspecific_i1.01394819
51MP0001963_abnormal_hearing_physiology0.98653863
52MP0004742_abnormal_vestibular_system0.95500172
53MP0009053_abnormal_anal_canal0.94605002
54MP0004233_abnormal_muscle_weight0.92811934
55MP0008995_early_reproductive_senescence0.89365302
56MP0002229_neurodegeneration0.88707230
57MP0002272_abnormal_nervous_system0.87596153
58MP0001440_abnormal_grooming_behavior0.85791714
59MP0001765_abnormal_ion_homeostasis0.85481701
60MP0001188_hyperpigmentation0.83529660
61MP0000681_abnormal_thyroid_gland0.80829993
62MP0002184_abnormal_innervation0.78501955
63MP0004782_abnormal_surfactant_physiolog0.77989675
64MP0003693_abnormal_embryo_hatching0.77763503
65MP0004811_abnormal_neuron_physiology0.77689789
66MP0003646_muscle_fatigue0.74337609
67MP0003329_amyloid_beta_deposits0.72624253
68MP0003137_abnormal_impulse_conducting0.72488999
69MP0005636_abnormal_mineral_homeostasis0.71994092
70MP0004085_abnormal_heartbeat0.68527384
71MP0001340_abnormal_eyelid_morphology0.68473237
72MP0003077_abnormal_cell_cycle0.68148227
73MP0006276_abnormal_autonomic_nervous0.68018997
74MP0001501_abnormal_sleep_pattern0.67598290
75MP0009697_abnormal_copulation0.67374938
76MP0002882_abnormal_neuron_morphology0.67194124
77MP0005253_abnormal_eye_physiology0.64439295
78MP0000467_abnormal_esophagus_morphology0.61678877
79MP0005666_abnormal_adipose_tissue0.61427642
80MP0001727_abnormal_embryo_implantation0.61078496
81MP0004957_abnormal_blastocyst_morpholog0.60839430
82MP0002160_abnormal_reproductive_system0.60613572
83MP0004510_myositis0.60387800
84MP0005551_abnormal_eye_electrophysiolog0.58951439
85MP0005395_other_phenotype0.56623578
86MP0005499_abnormal_olfactory_system0.56468351
87MP0005394_taste/olfaction_phenotype0.56468351
88MP0009046_muscle_twitch0.56455157
89MP0002064_seizures0.56041700
90MP0003861_abnormal_nervous_system0.53071393
91MP0002928_abnormal_bile_duct0.52307006
92MP0005266_abnormal_metabolism0.51703547
93MP0000003_abnormal_adipose_tissue0.50421601
94MP0005367_renal/urinary_system_phenotyp0.50108787
95MP0000516_abnormal_urinary_system0.50108787
96MP0005375_adipose_tissue_phenotype0.49936937
97MP0000049_abnormal_middle_ear0.48884866
98MP0003959_abnormal_lean_body0.47301341
99MP0000778_abnormal_nervous_system0.45888096
100MP0002127_abnormal_cardiovascular_syste0.45775447

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.79447863
2Asymmetric septal hypertrophy (HP:0001670)4.88073886
3Absent/shortened dynein arms (HP:0200106)4.86131148
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.86131148
5Bony spicule pigmentary retinopathy (HP:0007737)4.59578791
6Attenuation of retinal blood vessels (HP:0007843)4.51256396
7Bell-shaped thorax (HP:0001591)4.48885659
8Resting tremor (HP:0002322)3.99711981
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.97895344
10Male infertility (HP:0003251)3.86490894
11Abnormal respiratory motile cilium morphology (HP:0005938)3.85660725
12Abnormal respiratory epithelium morphology (HP:0012253)3.85660725
13Infertility (HP:0000789)3.72946378
14Abnormal ciliary motility (HP:0012262)3.62911690
15Enlarged epiphyses (HP:0010580)3.60287790
16Unilateral renal agenesis (HP:0000122)3.54029074
17Abnormality of the aortic arch (HP:0012303)3.53360747
18Abnormal respiratory motile cilium physiology (HP:0012261)3.52698633
19Aplasia/Hypoplasia of the earlobes (HP:0009906)3.39565588
20Facial shape deformation (HP:0011334)3.38221983
21Potter facies (HP:0002009)3.38221983
22Tubulointerstitial nephritis (HP:0001970)3.26088480
23Chronic hepatic failure (HP:0100626)3.17710898
24Cone-rod dystrophy (HP:0000548)3.16007157
25Abnormality of macular pigmentation (HP:0008002)3.14096468
26Peripheral hypomyelination (HP:0007182)3.13381716
27Upper limb muscle weakness (HP:0003484)3.09708999
28Abnormal rod and cone electroretinograms (HP:0008323)3.02987322
29Generalized aminoaciduria (HP:0002909)3.02882137
30Absent epiphyses (HP:0010577)3.01666671
31Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.01666671
32Impulsivity (HP:0100710)3.00022151
33Nasal polyposis (HP:0100582)2.99879171
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95536790
35Hypoplastic ischia (HP:0003175)2.93958097
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.93616030
37Hyperkalemia (HP:0002153)2.92135988
38Hypoplasia of the thymus (HP:0000778)2.86377286
39Abnormality of the costochondral junction (HP:0000919)2.77529532
40Abnormality of dental color (HP:0011073)2.67899793
41Neoplasm of the heart (HP:0100544)2.64201837
42Progressive sensorineural hearing impairment (HP:0000408)2.64157096
43Renovascular hypertension (HP:0100817)2.62958319
44Abnormality of the ischium (HP:0003174)2.60852511
45Double outlet right ventricle (HP:0001719)2.56498098
46Congenital malformation of the right heart (HP:0011723)2.56498098
47Postural instability (HP:0002172)2.53359727
48Retinal dysplasia (HP:0007973)2.52175981
49Myokymia (HP:0002411)2.49001644
50Abnormal spermatogenesis (HP:0008669)2.46414573
51Type II lissencephaly (HP:0007260)2.45588812
52Cerebral hypomyelination (HP:0006808)2.42020952
53Renal dysplasia (HP:0000110)2.40091686
54Failure to thrive in infancy (HP:0001531)2.38617933
55Transposition of the great arteries (HP:0001669)2.35302588
56Abnormal connection of the cardiac segments (HP:0011545)2.35302588
57Abnormal ventriculo-arterial connection (HP:0011563)2.35302588
58Stage 5 chronic kidney disease (HP:0003774)2.32824769
59Progressive cerebellar ataxia (HP:0002073)2.31894169
60Nephronophthisis (HP:0000090)2.31447604
61Widely patent fontanelles and sutures (HP:0004492)2.29201331
62Abnormality of the nasal mucosa (HP:0000433)2.28137184
63Recurrent corneal erosions (HP:0000495)2.28114575
64Azoospermia (HP:0000027)2.23755484
65Spastic paraparesis (HP:0002313)2.23524753
66Insulin-resistant diabetes mellitus (HP:0000831)2.23202364
67Amblyopia (HP:0000646)2.19739481
68Abnormality of the epiphysis of the femoral head (HP:0010574)2.17954301
69Truncal obesity (HP:0001956)2.11601496
70Abnormality of the pubic bones (HP:0003172)2.10011087
71Hypoplasia of the brainstem (HP:0002365)2.07732312
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.07732312
73Hand muscle atrophy (HP:0009130)2.06773430
74Amelogenesis imperfecta (HP:0000705)2.06644990
75Menstrual irregularities (HP:0000858)2.06516917
76Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.02367039
77Abnormality of femoral epiphyses (HP:0006499)2.02367039
78Abnormal urine output (HP:0012590)1.96435385
79Horizontal nystagmus (HP:0000666)1.93234627
80Abnormality of the renal medulla (HP:0100957)1.91732218
81Hyperuricemia (HP:0002149)1.91220955
82Increased purine levels (HP:0004368)1.91220955
83Cerebellar dysplasia (HP:0007033)1.87831466
84Mixed hearing impairment (HP:0000410)1.84239256
85Abnormality of the femoral head (HP:0003368)1.84113076
86Polyphagia (HP:0002591)1.84014746
87Hypoalphalipoproteinemia (HP:0003233)1.83677677
88Intellectual disability, moderate (HP:0002342)1.82059337
89Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81247736
90Focal segmental glomerulosclerosis (HP:0000097)1.81175713
91Short ribs (HP:0000773)1.80153822
92Epiphyseal dysplasia (HP:0002656)1.76133561
93Rhinitis (HP:0012384)1.76121618
94Optic nerve hypoplasia (HP:0000609)1.74984833
95Portal hypertension (HP:0001409)1.74081683
96Reticulocytosis (HP:0001923)1.70882673
97Hypoparathyroidism (HP:0000829)1.70609079
98Progressive hearing impairment (HP:0001730)1.67957504
99Abnormality of potassium homeostasis (HP:0011042)1.67620142
100Epileptic encephalopathy (HP:0200134)1.67334923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.70594412
2TESK16.08801236
3DDR24.37977182
4INSRR3.63479228
5PLK23.38199953
6ERBB33.17447312
7MAP4K22.76502491
8BRD42.76427119
9PNCK2.34952148
10PRKD32.10585435
11KSR21.91792292
12CAMK1G1.70535323
13STK381.68352658
14MARK11.67847304
15MST1R1.63023703
16CDK121.51494792
17UHMK11.47608593
18TRIM281.39030793
19PDPK11.33312274
20LATS21.33192636
21DYRK1B1.26622852
22MAPK151.24528065
23PDK11.21062931
24WNK11.17602136
25PIK3CG1.14886201
26DAPK21.11588852
27CDK71.08131313
28TESK21.04241780
29MAP3K91.03940320
30TYRO31.00563561
31RPS6KA21.00486186
32STK38L0.99441101
33ARAF0.98896547
34KSR10.98814019
35LATS10.93448098
36CCNB10.77460134
37BRAF0.76654466
38DYRK30.73903877
39MAP3K40.72373499
40SIK20.72283700
41MAPKAPK50.69837866
42NTRK30.69585856
43PRKCG0.68616246
44RPS6KA10.63884619
45PRKG20.61732225
46NEK60.61513540
47CAMK1D0.59001973
48BRSK10.57034717
49MINK10.56970901
50EEF2K0.56731642
51PINK10.55422641
52PRKCZ0.54901933
53NTRK20.54393554
54PAK60.54295028
55CDK20.53694854
56DYRK20.51911928
57MAP3K80.51768679
58MET0.51413138
59PTK2B0.51412350
60MAP3K20.50360648
61CAMK40.49681874
62FLT30.47992560
63CDK11A0.46518139
64SIK30.46149148
65MAP2K70.45494081
66CDK10.44164888
67BCR0.44027081
68MAP3K130.43852396
69BCKDK0.43791669
70PRKAA20.43506379
71PDGFRA0.43350461
72PRKG10.42583322
73GSK3B0.41257464
74SGK2230.40497693
75SGK4940.40497693
76MAPK10.38735863
77ROCK10.38681988
78CHEK10.38043565
79MAPK130.37753571
80EPHA40.36779024
81CDK140.36685990
82PAK20.31686258
83PKN20.30642641
84RAF10.30456252
85NME10.29825002
86CDK50.29697606
87RPS6KA40.29618489
88MAPK100.29159908
89CAMK2A0.27248993
90RPS6KL10.26435398
91RPS6KC10.26435398
92MAPK140.26206550
93CAMK10.25704688
94CAMK2G0.25675268
95CDK180.25170655
96MAPK80.24381058
97CDC70.23459062
98PRKCB0.23131962
99MARK20.22700619
100MAP2K20.22699870

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.81889492
2Fatty acid biosynthesis_Homo sapiens_hsa000614.51423004
3* Olfactory transduction_Homo sapiens_hsa047402.87040922
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.67406582
5Synaptic vesicle cycle_Homo sapiens_hsa047212.57144236
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44781938
7Arginine biosynthesis_Homo sapiens_hsa002202.21183283
8Phenylalanine metabolism_Homo sapiens_hsa003602.02759125
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.93445370
10RNA transport_Homo sapiens_hsa030131.86643603
11Oocyte meiosis_Homo sapiens_hsa041141.85449251
12Biosynthesis of amino acids_Homo sapiens_hsa012301.75240945
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71799210
14Taste transduction_Homo sapiens_hsa047421.65981662
15mRNA surveillance pathway_Homo sapiens_hsa030151.64203286
16Butanoate metabolism_Homo sapiens_hsa006501.58518032
17Glutamatergic synapse_Homo sapiens_hsa047241.55941123
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55131131
19Nicotine addiction_Homo sapiens_hsa050331.51320981
20Type II diabetes mellitus_Homo sapiens_hsa049301.46954656
21Arginine and proline metabolism_Homo sapiens_hsa003301.46221317
22Sulfur relay system_Homo sapiens_hsa041221.38830226
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37525391
24Selenocompound metabolism_Homo sapiens_hsa004501.37078346
25Endocytosis_Homo sapiens_hsa041441.33189359
26Estrogen signaling pathway_Homo sapiens_hsa049151.23745045
27Circadian entrainment_Homo sapiens_hsa047131.22093941
28Amphetamine addiction_Homo sapiens_hsa050311.20041908
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16137641
30Morphine addiction_Homo sapiens_hsa050321.15913735
31Cocaine addiction_Homo sapiens_hsa050301.12993768
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.12923207
33Dopaminergic synapse_Homo sapiens_hsa047281.09196061
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08036837
35Long-term potentiation_Homo sapiens_hsa047201.07139441
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03784954
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98511075
38Cardiac muscle contraction_Homo sapiens_hsa042600.96135160
39Fanconi anemia pathway_Homo sapiens_hsa034600.94750293
40Phototransduction_Homo sapiens_hsa047440.93881178
41Insulin secretion_Homo sapiens_hsa049110.92024803
42cAMP signaling pathway_Homo sapiens_hsa040240.91516968
43VEGF signaling pathway_Homo sapiens_hsa043700.89533737
44Cholinergic synapse_Homo sapiens_hsa047250.86560642
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.83745597
46Fatty acid metabolism_Homo sapiens_hsa012120.83586205
47GABAergic synapse_Homo sapiens_hsa047270.83252671
48Gastric acid secretion_Homo sapiens_hsa049710.81683758
49Carbon metabolism_Homo sapiens_hsa012000.79724736
50Salivary secretion_Homo sapiens_hsa049700.75852282
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75220898
52Tyrosine metabolism_Homo sapiens_hsa003500.74896784
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74706367
54Viral myocarditis_Homo sapiens_hsa054160.73857973
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73359762
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72496043
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70826029
58Tight junction_Homo sapiens_hsa045300.69474587
59Hedgehog signaling pathway_Homo sapiens_hsa043400.69417641
60Protein digestion and absorption_Homo sapiens_hsa049740.67661174
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66539175
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66294843
63Renin secretion_Homo sapiens_hsa049240.64651408
64AMPK signaling pathway_Homo sapiens_hsa041520.64550726
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63882089
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62142762
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61498511
68Inositol phosphate metabolism_Homo sapiens_hsa005620.60657507
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.57945421
70Purine metabolism_Homo sapiens_hsa002300.57298740
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.56613058
72Prolactin signaling pathway_Homo sapiens_hsa049170.56047872
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55651540
74Melanogenesis_Homo sapiens_hsa049160.55046559
75Huntingtons disease_Homo sapiens_hsa050160.54559899
76Circadian rhythm_Homo sapiens_hsa047100.54511291
77Calcium signaling pathway_Homo sapiens_hsa040200.53478783
78Vitamin B6 metabolism_Homo sapiens_hsa007500.52287692
79Oxytocin signaling pathway_Homo sapiens_hsa049210.48046878
80Long-term depression_Homo sapiens_hsa047300.47991181
81Fat digestion and absorption_Homo sapiens_hsa049750.47726652
82Antigen processing and presentation_Homo sapiens_hsa046120.44906664
83Steroid biosynthesis_Homo sapiens_hsa001000.44333651
84Hippo signaling pathway_Homo sapiens_hsa043900.43760758
85ABC transporters_Homo sapiens_hsa020100.43497971
86Alcoholism_Homo sapiens_hsa050340.43486280
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41432655
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40292454
89Glioma_Homo sapiens_hsa052140.40277521
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39419760
91Glucagon signaling pathway_Homo sapiens_hsa049220.36623674
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36235360
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.36215028
94Insulin signaling pathway_Homo sapiens_hsa049100.35973069
95Dorso-ventral axis formation_Homo sapiens_hsa043200.35092019
96Adherens junction_Homo sapiens_hsa045200.34996864
97Axon guidance_Homo sapiens_hsa043600.34577410
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34289229
99Thyroid hormone synthesis_Homo sapiens_hsa049180.33925697
100Serotonergic synapse_Homo sapiens_hsa047260.31863151

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