OR10R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of autophagic vacuole assembly (GO:2000785)9.43776784
2radial glial cell differentiation (GO:0060019)8.61139703
3V(D)J recombination (GO:0033151)8.17599898
4regulation of receptor binding (GO:1900120)7.97104832
5mast cell degranulation (GO:0043303)7.85237292
6mast cell activation involved in immune response (GO:0002279)7.85237292
7regulation of vacuole organization (GO:0044088)7.83323128
8cellular response to lithium ion (GO:0071285)7.46889055
9histone H3-K36 demethylation (GO:0070544)7.06180169
10tongue development (GO:0043586)6.94695285
11positive regulation of granulocyte differentiation (GO:0030854)6.64675810
12C21-steroid hormone biosynthetic process (GO:0006700)6.47308874
13negative regulation of macroautophagy (GO:0016242)6.16841514
14mast cell activation (GO:0045576)5.78382166
15regulation of granulocyte differentiation (GO:0030852)5.71457238
16omega-hydroxylase P450 pathway (GO:0097267)5.49566434
17negative regulation of T cell apoptotic process (GO:0070233)5.49076572
18regulation of interleukin-13 production (GO:0032656)5.47187818
19positive regulation by host of viral transcription (GO:0043923)5.46435142
20negative regulation of bone resorption (GO:0045779)5.38424725
21negative regulation of thymocyte apoptotic process (GO:0070244)5.31540544
22patterning of blood vessels (GO:0001569)5.23958493
23negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.14084288
24negative regulation of organelle assembly (GO:1902116)5.13639329
25motile cilium assembly (GO:0044458)5.05231856
26granulocyte differentiation (GO:0030851)5.01596668
27hypothalamus development (GO:0021854)4.87100842
28dentate gyrus development (GO:0021542)4.69130152
29membrane tubulation (GO:0097320)4.58113360
30CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.48558720
31T-helper cell differentiation (GO:0042093)4.48558720
32DNA double-strand break processing (GO:0000729)4.48466878
33forebrain neuron differentiation (GO:0021879)4.47152036
34anatomical structure regression (GO:0060033)4.45422501
35developmental pigmentation (GO:0048066)4.44117255
36negative regulation of phagocytosis (GO:0050765)4.42182044
37cellular response to interleukin-15 (GO:0071350)4.33043125
38regulation of interleukin-4 production (GO:0032673)4.31814326
39negative regulation of bone remodeling (GO:0046851)4.30019059
40response to lithium ion (GO:0010226)4.27128842
41regulation of interleukin-5 production (GO:0032674)4.26006826
42coenzyme catabolic process (GO:0009109)4.20845782
43apoptotic process involved in morphogenesis (GO:0060561)4.19357590
44regulation of exit from mitosis (GO:0007096)4.09688016
45negative regulation of granulocyte differentiation (GO:0030853)4.02093741
46regulation of ARF GTPase activity (GO:0032312)3.98952873
47T cell differentiation involved in immune response (GO:0002292)3.91274432
48alpha-beta T cell differentiation involved in immune response (GO:0002293)3.91274432
49alpha-beta T cell activation involved in immune response (GO:0002287)3.91274432
50lysosome localization (GO:0032418)3.90622817
51negative regulation of macrophage differentiation (GO:0045650)3.89028090
52smooth muscle cell differentiation (GO:0051145)3.80229709
53somatic stem cell division (GO:0048103)3.75114088
54long term synaptic depression (GO:0060292)3.74172736
55negative regulation of autophagy (GO:0010507)3.73024296
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.72558043
57response to hydroperoxide (GO:0033194)3.60743243
58negative regulation of tissue remodeling (GO:0034104)3.59989600
59negative regulation of striated muscle cell apoptotic process (GO:0010664)3.57771755
60telomere maintenance via semi-conservative replication (GO:0032201)3.57270357
61negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.55250733
62CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.53877338
63barbed-end actin filament capping (GO:0051016)3.52204587
64regulation of phosphoprotein phosphatase activity (GO:0043666)3.51852189
65negative regulation of necroptotic process (GO:0060546)3.50069140
66cortical actin cytoskeleton organization (GO:0030866)3.49728736
67regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.47829127
68negative regulation of metanephros development (GO:0072217)3.46871470
69regulation of macrophage differentiation (GO:0045649)3.41849968
70cellular response to interleukin-4 (GO:0071353)3.39425449
71apoptotic process involved in development (GO:1902742)3.37776604
72B cell proliferation (GO:0042100)3.35131263
73modulation by host of viral transcription (GO:0043921)3.35121049
74modulation by host of symbiont transcription (GO:0052472)3.35121049
75DNA replication initiation (GO:0006270)3.35043101
76cytoplasmic mRNA processing body assembly (GO:0033962)3.30826009
77leukocyte degranulation (GO:0043299)3.30240536
78C21-steroid hormone metabolic process (GO:0008207)3.27634194
79heterochromatin organization (GO:0070828)3.26652812
80positive regulation of B cell proliferation (GO:0030890)3.26624328
81negative regulation of lymphocyte apoptotic process (GO:0070229)3.26426316
82lymphocyte homeostasis (GO:0002260)3.25533354
83activated T cell proliferation (GO:0050798)3.25516873
84response to interleukin-15 (GO:0070672)3.23625942
85cellular response to ammonium ion (GO:0071242)3.23478187
86positive regulation of protein kinase C signaling (GO:0090037)3.19135311
87type B pancreatic cell development (GO:0003323)3.15964326
88cellular response to epinephrine stimulus (GO:0071872)3.15657430
89myoblast migration (GO:0051451)3.14964085
90CD4-positive, alpha-beta T cell activation (GO:0035710)3.14699843
91regulation of protein kinase A signaling (GO:0010738)3.14681488
92modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.13991045
93positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.09302247
94somatic cell DNA recombination (GO:0016444)3.07567597
95somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.07567597
96positive regulation of macrophage differentiation (GO:0045651)3.07538607
97low-density lipoprotein particle clearance (GO:0034383)3.06751957
98cortical cytoskeleton organization (GO:0030865)3.06673351
99regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.04451103
100regulation of cellular extravasation (GO:0002691)2.99352834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human9.88209343
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.87898314
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.17635797
4IGF1R_20145208_ChIP-Seq_DFB_Human4.06811105
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78436264
6AR_21572438_ChIP-Seq_LNCaP_Human2.67188157
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52096348
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39472555
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.19814646
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.08359543
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.03213311
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.5286051
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99999022
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.99076785
15RUNX_20019798_ChIP-Seq_JUKART_Human1.91871957
16WDR5_24793694_ChIP-Seq_LNCAP_Human1.81233833
17ER_23166858_ChIP-Seq_MCF-7_Human1.80621428
18E2F7_22180533_ChIP-Seq_HELA_Human1.77256680
19SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.74764278
20* GATA3_27048872_Chip-Seq_THYMUS_Human1.69636812
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68682528
22MYB_26560356_Chip-Seq_TH2_Human1.65859688
23UTX_26944678_Chip-Seq_JUKART_Human1.60858192
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.55821556
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49341069
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48450403
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42045311
28KDM2B_26808549_Chip-Seq_DND41_Human1.41920914
29RXR_22108803_ChIP-Seq_LS180_Human1.37654999
30MAF_26560356_Chip-Seq_TH2_Human1.34182490
31MYC_22102868_ChIP-Seq_BL_Human1.33144736
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27231825
33VDR_21846776_ChIP-Seq_THP-1_Human1.24879828
34SCL_19346495_ChIP-Seq_HPC-7_Human1.21438436
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21283836
36MYB_26560356_Chip-Seq_TH1_Human1.20577931
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20014305
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.16946464
39TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05383798
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03250767
41MAF_26560356_Chip-Seq_TH1_Human1.03115441
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01601441
43VDR_24763502_ChIP-Seq_THP-1_Human1.00870362
44E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98177802
45AHR_22903824_ChIP-Seq_MCF-7_Human0.95996290
46SPI1_23127762_ChIP-Seq_K562_Human0.93207146
47KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92891091
48STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92886992
49PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90982767
50VDR_24787735_ChIP-Seq_THP-1_Human0.90651358
51CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88991045
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88157524
53CTCF_21964334_Chip-Seq_Bcells_Human0.86156469
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85693999
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84085909
56ZNF274_21170338_ChIP-Seq_K562_Hela0.83217714
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.82076870
58RUNX1_27514584_Chip-Seq_MCF-7_Human0.80630419
59ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80265744
60CBP_21632823_ChIP-Seq_H3396_Human0.79143267
61ARNT_22903824_ChIP-Seq_MCF-7_Human0.77768232
62CHD1_26751641_Chip-Seq_LNCaP_Human0.76397950
63CIITA_25753668_ChIP-Seq_RAJI_Human0.76192097
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72170210
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72042537
66MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71614392
67GATA3_26560356_Chip-Seq_TH2_Human0.69935911
68CDX2_22108803_ChIP-Seq_LS180_Human0.67732852
69KDM5A_27292631_Chip-Seq_BREAST_Human0.67273056
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66285410
71E2F4_17652178_ChIP-ChIP_JURKAT_Human0.65904810
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65822226
73BRD4_25478319_ChIP-Seq_HGPS_Human0.65585364
74* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.64469290
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64427682
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.63519834
77KDM2B_26808549_Chip-Seq_JURKAT_Human0.62131284
78TDRD3_21172665_ChIP-Seq_MCF-7_Human0.61542389
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.61333483
80CREB1_26743006_Chip-Seq_LNCaP_Human0.60026671
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59869740
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.59098528
83OCT1_27270436_Chip-Seq_PROSTATE_Human0.59068268
84TBL1_22424771_ChIP-Seq_293T_Human0.57865234
85CTCF_27219007_Chip-Seq_Bcells_Human0.57425944
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.57115874
87* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.56479620
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55680544
89ELF5_23300383_ChIP-Seq_T47D_Human0.55612634
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.54908898
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.54154171
92WT1_19549856_ChIP-ChIP_CCG9911_Human0.53646493
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.52529669
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.51284647
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.51006918
96ERA_21632823_ChIP-Seq_H3396_Human0.50875044
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.50321345
98GBX2_23144817_ChIP-Seq_PC3_Human0.49470084
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.49154165
100CTCF_20526341_ChIP-Seq_ESCs_Human0.48348637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle6.77074171
2MP0003763_abnormal_thymus_physiology5.01467019
3MP0001849_ear_inflammation4.18032555
4MP0002132_abnormal_respiratory_system3.75834892
5MP0000678_abnormal_parathyroid_gland3.61579822
6MP0005075_abnormal_melanosome_morpholog3.41059073
7MP0005503_abnormal_tendon_morphology3.28367897
8MP0010094_abnormal_chromosome_stability2.57555384
9MP0000703_abnormal_thymus_morphology2.53662387
10MP0000681_abnormal_thyroid_gland2.43293283
11MP0004484_altered_response_of2.41531422
12MP0003315_abnormal_perineum_morphology2.40527091
13MP0000747_muscle_weakness2.31859003
14MP0002249_abnormal_larynx_morphology2.24823716
15MP0009840_abnormal_foam_cell2.22836240
16MP0003136_yellow_coat_color2.21701178
17MP0005166_decreased_susceptibility_to2.16928624
18MP0006035_abnormal_mitochondrial_morpho2.15806871
19MP0010234_abnormal_vibrissa_follicle2.10312385
20MP0001270_distended_abdomen2.09225436
21MP0005394_taste/olfaction_phenotype1.99690266
22MP0005499_abnormal_olfactory_system1.99690266
23MP0008004_abnormal_stomach_pH1.91254156
24MP0008789_abnormal_olfactory_epithelium1.89653737
25MP0001188_hyperpigmentation1.83637792
26MP0009697_abnormal_copulation1.77185611
27MP0002876_abnormal_thyroid_physiology1.75284225
28MP0000685_abnormal_immune_system1.74661479
29MP0003828_pulmonary_edema1.69284462
30MP0005646_abnormal_pituitary_gland1.61758457
31MP0009278_abnormal_bone_marrow1.53340955
32MP0002722_abnormal_immune_system1.49778357
33MP0005671_abnormal_response_to1.47619549
34MP0001529_abnormal_vocalization1.47588299
35MP0002405_respiratory_system_inflammati1.46769367
36MP0000049_abnormal_middle_ear1.40399631
37MP0001800_abnormal_humoral_immune1.35509683
38MP0002233_abnormal_nose_morphology1.33033729
39MP0001879_abnormal_lymphatic_vessel1.28206030
40MP0003385_abnormal_body_wall1.27167820
41MP0002166_altered_tumor_susceptibility1.23437344
42MP0002160_abnormal_reproductive_system1.23399075
43MP0005409_darkened_coat_color1.21429279
44MP0002398_abnormal_bone_marrow1.16995320
45MP0003077_abnormal_cell_cycle1.14842220
46MP0002420_abnormal_adaptive_immunity1.14260689
47MP0001944_abnormal_pancreas_morphology1.13686648
48MP0010368_abnormal_lymphatic_system1.13072600
49MP0005000_abnormal_immune_tolerance1.12157724
50MP0001819_abnormal_immune_cell1.09439161
51MP0002092_abnormal_eye_morphology1.09300966
52MP0002108_abnormal_muscle_morphology1.07376125
53MP0003868_abnormal_feces_composition1.06970094
54MP0001502_abnormal_circadian_rhythm1.05909096
55MP0003935_abnormal_craniofacial_develop1.03707291
56MP0001835_abnormal_antigen_presentation1.03514738
57MP0002148_abnormal_hypersensitivity_rea1.03033957
58MP0005385_cardiovascular_system_phenoty1.02831855
59MP0001544_abnormal_cardiovascular_syste1.02831855
60MP0000716_abnormal_immune_system1.01566126
61MP0000465_gastrointestinal_hemorrhage1.01550561
62MP0003693_abnormal_embryo_hatching1.00769997
63MP0002098_abnormal_vibrissa_morphology0.99372201
64MP0005187_abnormal_penis_morphology0.95699043
65MP0010386_abnormal_urinary_bladder0.95044258
66MP0008770_decreased_survivor_rate0.89452327
67MP0009785_altered_susceptibility_to0.87293648
68MP0000477_abnormal_intestine_morphology0.87212392
69MP0002138_abnormal_hepatobiliary_system0.85979612
70MP0000627_abnormal_mammary_gland0.82372542
71MP0003724_increased_susceptibility_to0.81219868
72MP0002127_abnormal_cardiovascular_syste0.80708020
73MP0002638_abnormal_pupillary_reflex0.80388590
74MP0006036_abnormal_mitochondrial_physio0.80137456
75MP0000490_abnormal_crypts_of0.78054315
76MP0001790_abnormal_immune_system0.77176672
77MP0005387_immune_system_phenotype0.77176672
78MP0005397_hematopoietic_system_phenotyp0.76779052
79MP0001545_abnormal_hematopoietic_system0.76779052
80MP0004084_abnormal_cardiac_muscle0.75797378
81MP0000689_abnormal_spleen_morphology0.74699349
82MP0003936_abnormal_reproductive_system0.74392276
83MP0002998_abnormal_bone_remodeling0.73893311
84MP0000462_abnormal_digestive_system0.73311957
85MP0010630_abnormal_cardiac_muscle0.73269059
86MP0005025_abnormal_response_to0.72684199
87MP0009250_abnormal_appendicular_skeleto0.72303039
88MP0001984_abnormal_olfaction0.71187851
89MP0001845_abnormal_inflammatory_respons0.69477539
90MP0004087_abnormal_muscle_fiber0.68272162
91MP0006072_abnormal_retinal_apoptosis0.67888863
92MP0005174_abnormal_tail_pigmentation0.67331452
93MP0005464_abnormal_platelet_physiology0.66994798
94MP0002452_abnormal_antigen_presenting0.66880533
95MP0001243_abnormal_dermal_layer0.64696858
96MP0005391_vision/eye_phenotype0.64164806
97MP0004947_skin_inflammation0.63831455
98MP0000759_abnormal_skeletal_muscle0.62586712
99MP0000537_abnormal_urethra_morphology0.62569616
100MP0002429_abnormal_blood_cell0.62041753

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)8.21884881
2B lymphocytopenia (HP:0010976)7.27808224
3Thyroiditis (HP:0100646)6.73283782
4Hypoplasia of the thymus (HP:0000778)6.41083464
5Abnormality of B cell number (HP:0010975)6.40827584
6Panhypogammaglobulinemia (HP:0003139)6.21955401
7Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)6.20568589
8Reduced antithrombin III activity (HP:0001976)5.90779047
9Severe combined immunodeficiency (HP:0004430)5.73873989
10Thoracic kyphosis (HP:0002942)5.37901404
11High anterior hairline (HP:0009890)5.07253708
12Aplasia/Hypoplasia involving the sinuses (HP:0009120)5.04939003
13Abnormality of the frontal sinuses (HP:0002687)5.03337411
14Combined immunodeficiency (HP:0005387)4.69070626
15Eosinophilia (HP:0001880)4.50224302
16Unsteady gait (HP:0002317)4.17097855
17Hypoproteinemia (HP:0003075)3.93488803
18Acute lymphatic leukemia (HP:0006721)3.89889272
19T lymphocytopenia (HP:0005403)3.89143918
20Lower limb hyperreflexia (HP:0002395)3.86641408
21Facial hemangioma (HP:0000329)3.71926353
22Aplasia cutis congenita (HP:0001057)3.71076471
23Granulocytopenia (HP:0001913)3.68770770
24Abnormality of the thoracic spine (HP:0100711)3.68200091
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.64740863
26Hypothermia (HP:0002045)3.56618630
27Thoracolumbar scoliosis (HP:0002944)3.50660917
28Abnormality of T cell number (HP:0011839)3.34790936
29Recurrent viral infections (HP:0004429)3.33120511
30Abnormality of eosinophils (HP:0001879)3.21111756
31Median cleft lip (HP:0000161)3.17194515
32Recurrent fungal infections (HP:0002841)3.14307442
33Oligodontia (HP:0000677)3.13895569
34Abnormality of the intrinsic pathway (HP:0010989)3.07009241
35Capillary hemangiomas (HP:0005306)2.93042519
36Basal ganglia calcification (HP:0002135)2.91112968
37Sensory axonal neuropathy (HP:0003390)2.80367336
38Abnormality of the incisor (HP:0000676)2.72950733
39IgG deficiency (HP:0004315)2.69683065
40Atonic seizures (HP:0010819)2.63008955
41Self-mutilation (HP:0000742)2.61105662
42Benign neoplasm of the central nervous system (HP:0100835)2.56764057
43Abnormality of the lumbar spine (HP:0100712)2.50246027
44Erythroderma (HP:0001019)2.48388979
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42576612
46High pitched voice (HP:0001620)2.39941521
47Absent thumb (HP:0009777)2.36383825
48Protruding tongue (HP:0010808)2.33322514
49Multiple lipomas (HP:0001012)2.31010061
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.28662197
51Skin tags (HP:0010609)2.27262875
52Carpal bone hypoplasia (HP:0001498)2.26125590
53Colitis (HP:0002583)2.16770532
54Broad nasal tip (HP:0000455)2.11954408
55Thyroid-stimulating hormone excess (HP:0002925)2.11644053
56Chronic diarrhea (HP:0002028)2.07272360
57Preauricular skin tag (HP:0000384)2.05508920
58Abnormality of the ileum (HP:0001549)1.98036390
59Prominent nose (HP:0000448)1.97656094
60Abnormality of the basal ganglia (HP:0002134)1.96673600
61Abnormality of T cells (HP:0002843)1.94450572
62Abnormality of the thymus (HP:0000777)1.92812959
63Hyporeflexia of lower limbs (HP:0002600)1.90720721
64Thickened helices (HP:0000391)1.89083978
65Coxa valga (HP:0002673)1.88222902
66Intellectual disability, progressive (HP:0006887)1.87720428
67Asymmetry of the thorax (HP:0001555)1.86236760
68Leukocytosis (HP:0001974)1.86112023
69Aplasia/Hypoplasia of the thymus (HP:0010515)1.85748622
70Squamous cell carcinoma (HP:0002860)1.82352348
71Abnormality of the shoulder girdle musculature (HP:0001435)1.81809378
72Small epiphyses (HP:0010585)1.81149025
73Popliteal pterygium (HP:0009756)1.79160723
74Abnormality of lateral ventricle (HP:0030047)1.75654301
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.73607618
76IgM deficiency (HP:0002850)1.72645099
77Meningioma (HP:0002858)1.71308104
78Hypoplasia of the maxilla (HP:0000327)1.70625600
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69332026
80Abnormal protein N-linked glycosylation (HP:0012347)1.69332026
81Abnormal protein glycosylation (HP:0012346)1.69332026
82Abnormal glycosylation (HP:0012345)1.69332026
83Skull defect (HP:0001362)1.68990586
84Ketosis (HP:0001946)1.66011754
85Recurrent sinusitis (HP:0011108)1.64155839
86Ureteral duplication (HP:0000073)1.63758451
87Abnormality of endocrine pancreas physiology (HP:0012093)1.62897833
88Abnormality of the pancreatic islet cells (HP:0006476)1.62897833
89Papilledema (HP:0001085)1.62227269
90Poor head control (HP:0002421)1.59178238
91Xerostomia (HP:0000217)1.58289130
92Syringomyelia (HP:0003396)1.57612362
93Spinal cord lesions (HP:0100561)1.57612362
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.56530109
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.56530109
96Inflammation of the large intestine (HP:0002037)1.56179486
97Global brain atrophy (HP:0002283)1.55278187
98Abnormality of cochlea (HP:0000375)1.54721790
99IgA deficiency (HP:0002720)1.53029130
100Recurrent cutaneous fungal infections (HP:0011370)1.52292645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK6.14792485
2CSNK1A1L4.78861666
3CSNK1G34.59353461
4MAP2K73.98188875
5MARK33.88175852
6CSNK1G13.73497539
7CSNK1G23.64435973
8ZAP703.27490054
9NEK23.07879874
10MAP3K102.77737767
11TLK12.24956533
12BMPR1B2.10726928
13ZAK2.10656524
14FRK1.89301440
15DYRK31.75647163
16PINK11.68381267
17RPS6KA41.66513872
18CDK31.65940878
19PDGFRB1.62278251
20FGFR21.59149051
21ICK1.58559193
22EIF2AK31.50981928
23SGK2231.47202782
24SGK4941.47202782
25CDK121.45320203
26MELK1.42781175
27PRKCQ1.17624626
28TGFBR11.17103918
29EEF2K1.13778132
30MAP3K11.13426719
31MAP4K11.12595902
32MAP3K131.08199190
33NME21.04858364
34CDK81.00307960
35STK41.00284823
36RPS6KB10.99155081
37WEE10.94993740
38LATS10.91666710
39SGK20.88920603
40MAP3K90.87694159
41ARAF0.86914531
42BTK0.86292751
43VRK10.82419210
44CSNK1A10.78401930
45RET0.74519170
46SYK0.74174979
47MAP3K50.70404106
48MTOR0.62244761
49OBSCN0.62112799
50HIPK20.61543233
51RPS6KA50.60731578
52FES0.59683709
53CSNK1D0.57338501
54CAMK40.56181082
55ATM0.55681727
56CDC70.54947271
57MAPK120.54490843
58MST1R0.52344508
59GRK60.50330501
60MINK10.48662815
61MAP3K80.48177865
62SGK30.46664037
63MAPK110.43917772
64PKN20.43282138
65TIE10.40991241
66AKT20.34308970
67RPS6KA20.34002433
68PDPK10.33794492
69MOS0.32980002
70FGFR30.32453730
71CDK70.30795369
72DYRK20.29531840
73PAK10.29467253
74DAPK30.28997937
75MAPK150.28150707
76AURKA0.27934697
77AURKB0.25081912
78MAP3K20.24958429
79TRIB30.23909546
80CDK140.23873226
81HCK0.23267367
82RPS6KC10.23123287
83RPS6KL10.23123287
84MAP3K30.22385118
85PDK10.21402769
86CDK50.20416668
87IRAK20.20062886
88MAPK90.19121330
89CDK90.19102371
90PLK10.19056728
91MAPKAPK30.18726819
92RPS6KA10.17966905
93PRKAA10.17827782
94PRKCB0.16924476
95ADRBK20.16574037
96PIK3CG0.15279637
97RPS6KA60.15264114
98MAPK130.13498658
99EGFR0.12219547
100MAPK100.11594899

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.63016683
2Systemic lupus erythematosus_Homo sapiens_hsa053223.64362364
3Alcoholism_Homo sapiens_hsa050343.58386474
4Renin secretion_Homo sapiens_hsa049242.68932889
5* Olfactory transduction_Homo sapiens_hsa047402.68682580
6Thyroid cancer_Homo sapiens_hsa052162.51572467
7T cell receptor signaling pathway_Homo sapiens_hsa046602.47440368
8Glioma_Homo sapiens_hsa052142.43179533
9Endometrial cancer_Homo sapiens_hsa052132.30146772
10Oxytocin signaling pathway_Homo sapiens_hsa049212.19879850
11Melanogenesis_Homo sapiens_hsa049162.10357217
12Primary immunodeficiency_Homo sapiens_hsa053402.10293908
13Salivary secretion_Homo sapiens_hsa049702.04647072
14DNA replication_Homo sapiens_hsa030302.02555102
15Long-term potentiation_Homo sapiens_hsa047202.01873961
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.96901328
17Amphetamine addiction_Homo sapiens_hsa050311.90989389
18Gastric acid secretion_Homo sapiens_hsa049711.84446332
19cGMP-PKG signaling pathway_Homo sapiens_hsa040221.82367165
20B cell receptor signaling pathway_Homo sapiens_hsa046621.67629858
21Circadian entrainment_Homo sapiens_hsa047131.54966484
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52679504
23Estrogen signaling pathway_Homo sapiens_hsa049151.51122526
24Prostate cancer_Homo sapiens_hsa052151.46331553
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.41099441
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37819098
27Hematopoietic cell lineage_Homo sapiens_hsa046401.37613356
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35949925
29Pertussis_Homo sapiens_hsa051331.33280051
30Oocyte meiosis_Homo sapiens_hsa041141.32322555
31GnRH signaling pathway_Homo sapiens_hsa049121.32105694
32Glucagon signaling pathway_Homo sapiens_hsa049221.29549338
33Acute myeloid leukemia_Homo sapiens_hsa052211.25312889
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25088454
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14734138
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13991443
37Hepatitis B_Homo sapiens_hsa051611.13201029
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.12165325
39Dopaminergic synapse_Homo sapiens_hsa047281.11294758
40Wnt signaling pathway_Homo sapiens_hsa043101.08163491
41Viral carcinogenesis_Homo sapiens_hsa052031.07820096
42Calcium signaling pathway_Homo sapiens_hsa040201.07333804
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02778093
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99262002
45Non-small cell lung cancer_Homo sapiens_hsa052230.95332116
46Insulin signaling pathway_Homo sapiens_hsa049100.94445263
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.91992657
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91594624
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88502948
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87819864
51Circadian rhythm_Homo sapiens_hsa047100.87489258
52Basal cell carcinoma_Homo sapiens_hsa052170.83931526
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.82251035
54AMPK signaling pathway_Homo sapiens_hsa041520.78198792
55Colorectal cancer_Homo sapiens_hsa052100.76882097
56Rap1 signaling pathway_Homo sapiens_hsa040150.75129448
57TGF-beta signaling pathway_Homo sapiens_hsa043500.74203946
58FoxO signaling pathway_Homo sapiens_hsa040680.72465565
59Fanconi anemia pathway_Homo sapiens_hsa034600.72284429
60Ras signaling pathway_Homo sapiens_hsa040140.68987628
61Adherens junction_Homo sapiens_hsa045200.68919762
62cAMP signaling pathway_Homo sapiens_hsa040240.67185332
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66591334
64Melanoma_Homo sapiens_hsa052180.65170437
65Chemical carcinogenesis_Homo sapiens_hsa052040.64423518
66mTOR signaling pathway_Homo sapiens_hsa041500.61379250
67Tuberculosis_Homo sapiens_hsa051520.61094881
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58846708
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58462057
70PPAR signaling pathway_Homo sapiens_hsa033200.57482166
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55757943
72Apoptosis_Homo sapiens_hsa042100.52757970
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52240097
74Taste transduction_Homo sapiens_hsa047420.50902791
75Hedgehog signaling pathway_Homo sapiens_hsa043400.49698587
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49520162
77Pyrimidine metabolism_Homo sapiens_hsa002400.46753541
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44026091
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42658888
80Hippo signaling pathway_Homo sapiens_hsa043900.39620169
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37107150
82HTLV-I infection_Homo sapiens_hsa051660.36662378
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35848999
84Cholinergic synapse_Homo sapiens_hsa047250.35107902
85Measles_Homo sapiens_hsa051620.35039920
86Arachidonic acid metabolism_Homo sapiens_hsa005900.34286525
87beta-Alanine metabolism_Homo sapiens_hsa004100.33919136
88Axon guidance_Homo sapiens_hsa043600.32021068
89Herpes simplex infection_Homo sapiens_hsa051680.30554466
90Dorso-ventral axis formation_Homo sapiens_hsa043200.27140716
91Gap junction_Homo sapiens_hsa045400.26639202
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25937361
93MAPK signaling pathway_Homo sapiens_hsa040100.25884670
94Basal transcription factors_Homo sapiens_hsa030220.25286143
95Type II diabetes mellitus_Homo sapiens_hsa049300.25023086
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24263097
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24026095
98Hepatitis C_Homo sapiens_hsa051600.22577566
99Choline metabolism in cancer_Homo sapiens_hsa052310.22371371
100Pancreatic secretion_Homo sapiens_hsa049720.21511204

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