OPRL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70182781
2neuron cell-cell adhesion (GO:0007158)5.65176739
3vocalization behavior (GO:0071625)5.57301884
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.56300995
5response to peptidoglycan (GO:0032494)5.39973098
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.28466773
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.28466773
8modulation by symbiont of host immune response (GO:0052553)5.28466773
9positive regulation by symbiont of host defense response (GO:0052509)5.28466773
10modulation by symbiont of host defense response (GO:0052031)5.28466773
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.28466773
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.23591440
13negative regulation of cell killing (GO:0031342)5.23591440
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.14616798
15synaptic vesicle exocytosis (GO:0016079)5.09920539
16regulation of glutamate receptor signaling pathway (GO:1900449)5.06893532
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.03057823
18protein localization to synapse (GO:0035418)5.00791925
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94182835
20neutrophil activation involved in immune response (GO:0002283)4.94026653
21positive regulation of gamma-delta T cell activation (GO:0046645)4.92141530
22synaptic vesicle maturation (GO:0016188)4.74943617
23macrophage activation involved in immune response (GO:0002281)4.73622669
24glutamate secretion (GO:0014047)4.73225383
25locomotory exploration behavior (GO:0035641)4.71793368
26regulation of synaptic vesicle exocytosis (GO:2000300)4.68936947
27detection of other organism (GO:0098543)4.64527779
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.62516974
29detection of bacterium (GO:0016045)4.49108705
30neuron recognition (GO:0008038)4.48881624
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42800437
32antigen processing and presentation of endogenous antigen (GO:0019883)4.34757071
33neurotransmitter secretion (GO:0007269)4.33412025
34glutamate receptor signaling pathway (GO:0007215)4.29313072
35exploration behavior (GO:0035640)4.26482153
36dendritic spine morphogenesis (GO:0060997)4.25018340
37neuronal action potential propagation (GO:0019227)4.21683992
38cellular extravasation (GO:0045123)4.21045731
39layer formation in cerebral cortex (GO:0021819)4.18058666
40regulation of synaptic vesicle transport (GO:1902803)4.15645324
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.13837185
42postsynaptic membrane organization (GO:0001941)4.13155541
43synaptic vesicle docking involved in exocytosis (GO:0016081)4.10351667
44regulation of mast cell degranulation (GO:0043304)4.07842377
45axonal fasciculation (GO:0007413)4.05827369
46synaptic transmission, glutamatergic (GO:0035249)4.02081433
47detection of external biotic stimulus (GO:0098581)3.96899042
48regulation of myeloid leukocyte mediated immunity (GO:0002886)3.96596652
49regulation of B cell receptor signaling pathway (GO:0050855)3.94922778
50neuron-neuron synaptic transmission (GO:0007270)3.93126988
51respiratory burst (GO:0045730)3.92125492
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.91353362
53presynaptic membrane assembly (GO:0097105)3.88285837
54leukocyte migration involved in inflammatory response (GO:0002523)3.87648370
55regulation of neuronal synaptic plasticity (GO:0048168)3.86317067
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85648006
57negative regulation of erythrocyte differentiation (GO:0045647)3.82743151
58detection of molecule of bacterial origin (GO:0032490)3.81023339
59leukocyte aggregation (GO:0070486)3.78282573
60microglial cell activation (GO:0001774)3.77693820
61regulation of mast cell activation involved in immune response (GO:0033006)3.76223229
62neutrophil activation (GO:0042119)3.76189456
63negative regulation of interleukin-12 production (GO:0032695)3.75710157
64regulation of leukocyte degranulation (GO:0043300)3.75380781
65positive regulation of mast cell activation (GO:0033005)3.73912640
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.73499686
67neurotransmitter transport (GO:0006836)3.69885742
68proline transport (GO:0015824)3.69568419
69regulation of regulated secretory pathway (GO:1903305)3.68427216
70neurotransmitter-gated ion channel clustering (GO:0072578)3.67303513
71regulation of synapse structural plasticity (GO:0051823)3.66919105
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66678347
73transmission of nerve impulse (GO:0019226)3.66306068
74response to muramyl dipeptide (GO:0032495)3.64082429
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.63609619
76response to host immune response (GO:0052572)3.63609619
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.63347697
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62269437
79immunoglobulin mediated immune response (GO:0016064)3.62149050
80presynaptic membrane organization (GO:0097090)3.62080301
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60403593
82response to histamine (GO:0034776)3.60400825
83positive regulation of synapse assembly (GO:0051965)3.58403357
84neutrophil mediated immunity (GO:0002446)3.57554892
85macrophage activation (GO:0042116)3.56941114
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54071398
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.53218043
88regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52722772
89myeloid cell activation involved in immune response (GO:0002275)3.49184566
90detection of biotic stimulus (GO:0009595)3.48056025
91regulation of postsynaptic membrane potential (GO:0060078)3.48044844
92positive regulation of mast cell degranulation (GO:0043306)3.46731846
93positive regulation of mast cell activation involved in immune response (GO:0033008)3.46731846
94long-term memory (GO:0007616)3.46531914
95negative regulation of leukocyte mediated immunity (GO:0002704)3.46028806
96cerebellar Purkinje cell differentiation (GO:0021702)3.45936239
97regulation of T-helper 2 cell differentiation (GO:0045628)3.45933017
98gamma-aminobutyric acid transport (GO:0015812)3.43899086
99positive regulation of membrane potential (GO:0045838)3.42456507
100negative regulation of microtubule polymerization (GO:0031115)3.41818128
101granulocyte activation (GO:0036230)3.40989587
102regulation of interferon-beta biosynthetic process (GO:0045357)3.40915290
103cell migration in hindbrain (GO:0021535)3.39070966
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38699946
105regulation of vesicle fusion (GO:0031338)3.37100677
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37069980
107regulation of mast cell activation (GO:0033003)3.36931212
108regulation of neurotransmitter levels (GO:0001505)3.36886465
109regulation of gamma-delta T cell activation (GO:0046643)3.34328956
110B cell receptor signaling pathway (GO:0050853)3.32243269
111regulation of synaptic transmission, glutamatergic (GO:0051966)3.31717121
112auditory behavior (GO:0031223)3.29163068
113regulation of glutamate secretion (GO:0014048)3.28861988
114activation of protein kinase A activity (GO:0034199)3.27078542
115germinal center formation (GO:0002467)3.26568622
116dendrite morphogenesis (GO:0048813)3.24311856
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24176742
118negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23682475
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23297197
120response to host (GO:0075136)3.23297197
121response to host defenses (GO:0052200)3.23297197
122synapse assembly (GO:0007416)3.22819795
123regulation of neurotransmitter secretion (GO:0046928)3.21479166
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.21454584
125synaptic vesicle endocytosis (GO:0048488)3.20799070
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20373538
127righting reflex (GO:0060013)3.20198892
128startle response (GO:0001964)3.18189410
129intraspecies interaction between organisms (GO:0051703)3.17017977
130social behavior (GO:0035176)3.17017977
131myeloid leukocyte mediated immunity (GO:0002444)3.14796900
132membrane depolarization (GO:0051899)3.14446984
133regulation of respiratory system process (GO:0044065)3.14048130
134mating behavior (GO:0007617)3.12600922
135regulation of dendritic spine morphogenesis (GO:0061001)3.12553194
136positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11296424
137central nervous system projection neuron axonogenesis (GO:0021952)3.11078588
138membrane hyperpolarization (GO:0060081)3.10998526
139long-term synaptic potentiation (GO:0060291)3.09801001
140response to interleukin-15 (GO:0070672)3.09773323
141response to auditory stimulus (GO:0010996)3.09690022
142positive regulation of regulated secretory pathway (GO:1903307)3.09163268
143membrane depolarization during action potential (GO:0086010)3.08930464
144neuromuscular process controlling posture (GO:0050884)3.08196789
145regulation of synaptic plasticity (GO:0048167)3.08049904
146positive regulation of B cell differentiation (GO:0045579)3.05259194
147regulation of synapse assembly (GO:0051963)3.04883625
148negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04788245
149pyrimidine nucleobase catabolic process (GO:0006208)3.04703622
150behavioral fear response (GO:0001662)3.03433825
151behavioral defense response (GO:0002209)3.03433825
152negative regulation of type 2 immune response (GO:0002829)3.02449226
153neuronal ion channel clustering (GO:0045161)3.01518355
154learning (GO:0007612)3.00876989
155positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.00660332
156prepulse inhibition (GO:0060134)3.00457227
157fear response (GO:0042596)2.98802796
158synapse organization (GO:0050808)2.98391279
159regulation of neurotransmitter transport (GO:0051588)2.96732454
160synaptic transmission (GO:0007268)2.96604567
161positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.95258303
162positive regulation of synapse maturation (GO:0090129)2.94836756
163regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94432285
164mechanosensory behavior (GO:0007638)2.93607449
165regulation of respiratory gaseous exchange (GO:0043576)2.92056297
166cellular potassium ion homeostasis (GO:0030007)2.91447151
167positive regulation of neurotransmitter secretion (GO:0001956)2.91137217
168innervation (GO:0060384)2.90747276
169positive regulation of neurotransmitter transport (GO:0051590)2.90255721
170leukocyte degranulation (GO:0043299)2.90062294
171negative regulation of T cell mediated immunity (GO:0002710)2.89473034
172regulation of ARF protein signal transduction (GO:0032012)2.86739197
173regulation of B cell differentiation (GO:0045577)2.83494556
174defense response to protozoan (GO:0042832)2.82959788
175regulation of gamma-delta T cell differentiation (GO:0045586)2.82083553
176cellular response to interleukin-15 (GO:0071350)2.81565005
177positive regulation of cellular amide metabolic process (GO:0034250)2.77946615
178lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76648848
179regulation of amyloid precursor protein catabolic process (GO:1902991)2.74005151
180interferon-gamma-mediated signaling pathway (GO:0060333)2.72228012
181negative regulation of phagocytosis (GO:0050765)2.69910784
182positive regulation of Rap GTPase activity (GO:0032854)2.65570741
183negative regulation of interleukin-6 production (GO:0032715)2.64943810
184negative regulation of cytokine production involved in immune response (GO:0002719)2.63724889
185regulation of type 2 immune response (GO:0002828)2.63370954
186neutrophil chemotaxis (GO:0030593)2.62904353
187regulation of macrophage cytokine production (GO:0010935)2.61714183
188positive regulation of type 2 immune response (GO:0002830)2.60922323
189production of molecular mediator involved in inflammatory response (GO:0002532)2.59850827
190negative regulation of toll-like receptor signaling pathway (GO:0034122)2.58350906
191positive thymic T cell selection (GO:0045059)2.58018826
192regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56989674
193actin filament polymerization (GO:0030041)2.56851742
194B cell mediated immunity (GO:0019724)2.55763018
195neutrophil migration (GO:1990266)2.55657066
196positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55420678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.70900632
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.00796378
3GBX2_23144817_ChIP-Seq_PC3_Human3.82018403
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.71739515
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14026851
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13485394
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06401831
8VDR_21846776_ChIP-Seq_THP-1_Human3.02548984
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99731590
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.96818591
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.88996883
12REST_21632747_ChIP-Seq_MESCs_Mouse2.78674525
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76738811
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.72035904
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66052914
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66052914
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65333048
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62737493
19VDR_24763502_ChIP-Seq_THP-1_Human2.58121417
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56236194
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.51830947
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49563550
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43400703
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40584740
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.40375912
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.38206433
27TAF15_26573619_Chip-Seq_HEK293_Human2.37342272
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37131532
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35816927
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35031477
31SPI1_23127762_ChIP-Seq_K562_Human2.34808794
32LXR_22292898_ChIP-Seq_THP-1_Human2.30167105
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.29566578
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26610891
35EZH2_27294783_Chip-Seq_ESCs_Mouse2.21527880
36* REST_18959480_ChIP-ChIP_MESCs_Mouse2.20024515
37SCL_19346495_ChIP-Seq_HPC-7_Human2.19831595
38KDM2B_26808549_Chip-Seq_DND41_Human2.17341472
39RNF2_27304074_Chip-Seq_ESCs_Mouse2.17186256
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16852508
41CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14144061
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12576499
43DROSHA_22980978_ChIP-Seq_HELA_Human2.11176821
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07791153
45RARB_27405468_Chip-Seq_BRAIN_Mouse2.06950638
46IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06155404
47CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01192551
48SPI1_23547873_ChIP-Seq_NB4_Human2.00352851
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99629443
50MYC_22102868_ChIP-Seq_BL_Human1.98933988
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.96928122
52AR_21572438_ChIP-Seq_LNCaP_Human1.96308311
53TCF7_22412390_ChIP-Seq_EML_Mouse1.94722454
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93432859
55UTX_26944678_Chip-Seq_JUKART_Human1.91294876
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90568120
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89507137
58MAF_26560356_Chip-Seq_TH1_Human1.87196467
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86022375
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78054539
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77540713
62RUNX_20019798_ChIP-Seq_JUKART_Human1.77091490
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73340022
64* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72628635
65IGF1R_20145208_ChIP-Seq_DFB_Human1.71627928
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70517741
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.70313425
68SMAD4_21799915_ChIP-Seq_A2780_Human1.68405727
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.68156264
70MAF_26560356_Chip-Seq_TH2_Human1.66076182
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63089795
72ZNF274_21170338_ChIP-Seq_K562_Hela1.60184044
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56196331
74P300_19829295_ChIP-Seq_ESCs_Human1.56189736
75BCL6_27268052_Chip-Seq_Bcells_Human1.56110463
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55640207
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55509028
78KDM2B_26808549_Chip-Seq_K562_Human1.54302830
79RNF2_27304074_Chip-Seq_NSC_Mouse1.53683176
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52875339
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52775941
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52704529
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50305366
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49580467
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47426090
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.47085752
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46869497
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.45641134
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.45417972
90P68_20966046_ChIP-Seq_HELA_Human1.43570385
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43057690
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42718252
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.41529843
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40680731
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38659591
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37414504
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36780214
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.36549024
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36044589
100BCOR_27268052_Chip-Seq_Bcells_Human1.35889478
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35279273
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34928222
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34536425
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34055527
105VDR_24787735_ChIP-Seq_THP-1_Human1.32928549
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.32761864
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32635957
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.32290266
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31823901
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31235286
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30397087
112AR_25329375_ChIP-Seq_VCAP_Human1.29417593
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27811699
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.27681364
115SMC4_20622854_ChIP-Seq_HELA_Human1.26417749
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26299850
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25080454
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24882739
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24665646
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.23489826
121FUS_26573619_Chip-Seq_HEK293_Human1.23429542
122MYB_26560356_Chip-Seq_TH2_Human1.22777998
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21211845
124* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21082762
125GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20787420
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18746650
127ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18547699
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15313526
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15008421
130VDR_22108803_ChIP-Seq_LS180_Human1.14896744
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14773806
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14101438
133P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13954304
134FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13700650
135OCT4_19829295_ChIP-Seq_ESCs_Human1.13461627
136STAT3_23295773_ChIP-Seq_U87_Human1.13181434
137GATA1_19941826_ChIP-Seq_K562_Human1.13146212
138* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12711639
139GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11331873
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11077972
141MYB_26560356_Chip-Seq_TH1_Human1.10954839
142CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10492217
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09980998
144CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09703078
145* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09681331
146AR_19668381_ChIP-Seq_PC3_Human1.09183756
147SPI1_20517297_ChIP-Seq_HL60_Human1.08959119
148RING1B_27294783_Chip-Seq_NPCs_Mouse1.08835686
149CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08554977
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07080452
151RUNX2_22187159_ChIP-Seq_PCA_Human1.05977219
152ER_23166858_ChIP-Seq_MCF-7_Human1.05965225
153RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05684464
154GATA3_27048872_Chip-Seq_THYMUS_Human1.05198107
155* TCF4_23295773_ChIP-Seq_U87_Human1.03516428
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03200805
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02710009
158ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02589849
159DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00355507
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99653191
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99653191
162* TET1_21451524_ChIP-Seq_MESCs_Mouse0.99219769
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98928588
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98558294
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.98124628
166JUN_21703547_ChIP-Seq_K562_Human0.97329717
167SMAD_19615063_ChIP-ChIP_OVARY_Human0.96310446
168E2F1_20622854_ChIP-Seq_HELA_Human0.95897919
169VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95625781
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95620800
171PRDM14_20953172_ChIP-Seq_ESCs_Human0.94946717
172TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94446261
173SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94264095
174GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94173257
175EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93681331
176WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93015644
177CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92826471
178NANOG_18555785_Chip-Seq_ESCs_Mouse0.91995881
179NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91872700
180AHR_22903824_ChIP-Seq_MCF-7_Human0.91570843
181CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91028341
182SMAD3_21741376_ChIP-Seq_ESCs_Human0.88599336
183KDM2B_26808549_Chip-Seq_REH_Human0.86769968
184RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84885973
185CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84710985
186ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84631173
187TP53_18474530_ChIP-ChIP_U2OS_Human0.83941261
188MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83889966
189CBP_20019798_ChIP-Seq_JUKART_Human0.83599763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.61049818
2MP0004859_abnormal_synaptic_plasticity5.32818372
3MP0003724_increased_susceptibility_to4.10602196
4MP0003303_peritoneal_inflammation3.96058000
5* MP0003635_abnormal_synaptic_transmissio3.88381569
6MP0003436_decreased_susceptibility_to3.78521454
7MP0004270_analgesia3.30091421
8MP0005423_abnormal_somatic_nervous3.25023091
9* MP0009745_abnormal_behavioral_response3.24376587
10* MP0002063_abnormal_learning/memory/cond3.18908539
11MP0001835_abnormal_antigen_presentation3.16080954
12MP0002064_seizures3.01131322
13MP0009046_muscle_twitch2.88707939
14MP0002419_abnormal_innate_immunity2.88043386
15MP0006276_abnormal_autonomic_nervous2.87882640
16* MP0002572_abnormal_emotion/affect_behav2.83239462
17* MP0001968_abnormal_touch/_nociception2.82988186
18MP0003172_abnormal_lysosome_physiology2.58842291
19MP0005025_abnormal_response_to2.55183994
20* MP0002734_abnormal_mechanical_nocicepti2.49253906
21MP0001440_abnormal_grooming_behavior2.46801893
22MP0002272_abnormal_nervous_system2.46002458
23MP0003122_maternal_imprinting2.44747544
24MP0001486_abnormal_startle_reflex2.42744986
25MP0005000_abnormal_immune_tolerance2.41181023
26MP0002736_abnormal_nociception_after2.40841577
27MP0001529_abnormal_vocalization2.30552345
28MP0003191_abnormal_cellular_cholesterol2.28321171
29MP0001800_abnormal_humoral_immune2.24703083
30MP0005387_immune_system_phenotype2.23594739
31MP0001790_abnormal_immune_system2.23594739
32MP0001501_abnormal_sleep_pattern2.17147192
33MP0000778_abnormal_nervous_system2.15694331
34MP0002420_abnormal_adaptive_immunity2.15084880
35MP0002822_catalepsy2.14310955
36MP0002723_abnormal_immune_serum2.13801208
37MP0009278_abnormal_bone_marrow2.13150400
38MP0001819_abnormal_immune_cell2.11770266
39MP0006082_CNS_inflammation2.10604639
40MP0005464_abnormal_platelet_physiology2.09862609
41MP0005671_abnormal_response_to2.09610988
42* MP0002067_abnormal_sensory_capabilities2.07152663
43MP0009785_altered_susceptibility_to2.05605838
44MP0002184_abnormal_innervation2.03867488
45MP0002452_abnormal_antigen_presenting2.03570684
46* MP0002733_abnormal_thermal_nociception2.01573532
47MP0000685_abnormal_immune_system1.99909451
48MP0008260_abnormal_autophagy1.98636823
49MP0005645_abnormal_hypothalamus_physiol1.95489674
50* MP0002735_abnormal_chemical_nociception1.93969779
51* MP0001970_abnormal_pain_threshold1.93627755
52MP0005386_behavior/neurological_phenoty1.90879326
53MP0004924_abnormal_behavior1.90879326
54MP0001986_abnormal_taste_sensitivity1.90721264
55MP0003787_abnormal_imprinting1.88220582
56MP0002557_abnormal_social/conspecific_i1.87261593
57MP0001533_abnormal_skeleton_physiology1.83205961
58MP0003075_altered_response_to1.79581945
59MP0005058_abnormal_lysosome_morphology1.78477917
60MP0002148_abnormal_hypersensitivity_rea1.68731194
61MP0004142_abnormal_muscle_tone1.67624616
62MP0004510_myositis1.61843800
63MP0004811_abnormal_neuron_physiology1.61604351
64MP0001984_abnormal_olfaction1.60808946
65MP0003183_abnormal_peptide_metabolism1.58654247
66* MP0001905_abnormal_dopamine_level1.58423506
67MP0003329_amyloid_beta_deposits1.57537298
68MP0002405_respiratory_system_inflammati1.57173386
69MP0003300_gastrointestinal_ulcer1.56307268
70MP0000465_gastrointestinal_hemorrhage1.55234254
71MP0008569_lethality_at_weaning1.54762411
72MP0005646_abnormal_pituitary_gland1.52737381
73MP0002132_abnormal_respiratory_system1.51813371
74MP0003690_abnormal_glial_cell1.51190728
75MP0000716_abnormal_immune_system1.50906468
76MP0002398_abnormal_bone_marrow1.50529222
77MP0001545_abnormal_hematopoietic_system1.49170003
78MP0005397_hematopoietic_system_phenotyp1.49170003
79MP0000955_abnormal_spinal_cord1.48095312
80MP0001502_abnormal_circadian_rhythm1.47635492
81MP0009780_abnormal_chondrocyte_physiolo1.46553465
82MP0003879_abnormal_hair_cell1.45767500
83MP0002909_abnormal_adrenal_gland1.44907077
84MP0005310_abnormal_salivary_gland1.44123213
85MP0002882_abnormal_neuron_morphology1.42778709
86MP0002066_abnormal_motor_capabilities/c1.40946274
87MP0004858_abnormal_nervous_system1.35457797
88MP0010386_abnormal_urinary_bladder1.34634137
89MP0003828_pulmonary_edema1.32058777
90MP0001845_abnormal_inflammatory_respons1.31462590
91MP0003866_abnormal_defecation1.28763021
92MP0003763_abnormal_thymus_physiology1.28623191
93MP0002102_abnormal_ear_morphology1.28599925
94MP0000751_myopathy1.25000933
95MP0001188_hyperpigmentation1.21419277
96MP0004947_skin_inflammation1.20382017
97MP0002837_dystrophic_cardiac_calcinosis1.17308633
98MP0000689_abnormal_spleen_morphology1.17260382
99MP0002722_abnormal_immune_system1.16297166
100MP0002152_abnormal_brain_morphology1.14898579
101MP0003121_genomic_imprinting1.14793414
102MP0002429_abnormal_blood_cell1.14254237
103MP0000569_abnormal_digit_pigmentation1.13148166
104MP0002638_abnormal_pupillary_reflex1.11772377
105MP0008469_abnormal_protein_level1.10782110
106MP0004742_abnormal_vestibular_system1.08288628
107MP0005166_decreased_susceptibility_to1.07637306
108MP0009764_decreased_sensitivity_to1.07258479
109MP0010155_abnormal_intestine_physiology1.06495996
110MP0002396_abnormal_hematopoietic_system1.05332697
111MP0003633_abnormal_nervous_system1.04247247
112MP0000013_abnormal_adipose_tissue1.02568614
113MP0001851_eye_inflammation1.01080887
114MP0004381_abnormal_hair_follicle1.00191444
115MP0000631_abnormal_neuroendocrine_gland0.99051937
116MP0008872_abnormal_physiological_respon0.97401945
117MP0000920_abnormal_myelination0.97207908
118MP0000015_abnormal_ear_pigmentation0.96943919
119MP0002876_abnormal_thyroid_physiology0.96187346
120MP0000703_abnormal_thymus_morphology0.95875235
121MP0005551_abnormal_eye_electrophysiolog0.95087942
122MP0002069_abnormal_eating/drinking_beha0.94145414
123MP0003123_paternal_imprinting0.92186069
124MP0002998_abnormal_bone_remodeling0.91636672
125MP0003631_nervous_system_phenotype0.91323061
126MP0002229_neurodegeneration0.91232946
127MP0004885_abnormal_endolymph0.88454704
128MP0002752_abnormal_somatic_nervous0.87476105
129MP0004145_abnormal_muscle_electrophysio0.86503588
130MP0005451_abnormal_body_composition0.86366816
131MP0005377_hearing/vestibular/ear_phenot0.86262783
132MP0003878_abnormal_ear_physiology0.86262783
133MP0008961_abnormal_basal_metabolism0.84366967
134MP0005535_abnormal_body_temperature0.83904896
135MP0008004_abnormal_stomach_pH0.83373161
136MP0004883_abnormal_blood_vessel0.83321815
137* MP0001963_abnormal_hearing_physiology0.82398233
138MP0005499_abnormal_olfactory_system0.82251930
139MP0005394_taste/olfaction_phenotype0.82251930
140MP0002277_abnormal_respiratory_mucosa0.80824016
141MP0002653_abnormal_ependyma_morphology0.79213954
142MP0006072_abnormal_retinal_apoptosis0.78254150
143MP0004085_abnormal_heartbeat0.77563968
144MP0005410_abnormal_fertilization0.77410796
145MP0005409_darkened_coat_color0.76313585
146MP0000343_altered_response_to0.73075112
147MP0009333_abnormal_splenocyte_physiolog0.72825684
148MP0003634_abnormal_glial_cell0.72125422
149MP0008874_decreased_physiological_sensi0.70687426
150MP0000858_altered_metastatic_potential0.69677646
151MP0003137_abnormal_impulse_conducting0.66432849
152MP0004215_abnormal_myocardial_fiber0.66293434
153MP0001943_abnormal_respiration0.66085820
154MP0002751_abnormal_autonomic_nervous0.65080278
155MP0003861_abnormal_nervous_system0.64711967
156MP0001177_atelectasis0.63060001
157MP0000026_abnormal_inner_ear0.62927312
158MP0003632_abnormal_nervous_system0.60649386
159MP0000604_amyloidosis0.60392582
160MP0001664_abnormal_digestion0.59259966
161MP0004484_altered_response_of0.57678647
162MP0002090_abnormal_vision0.57458734
163MP0002082_postnatal_lethality0.56804532
164MP0010770_preweaning_lethality0.56804532
165MP0001485_abnormal_pinna_reflex0.56787164
166MP0010769_abnormal_survival0.55132914
167MP0005253_abnormal_eye_physiology0.52895858
168MP0010768_mortality/aging0.52500957
169MP0003956_abnormal_body_size0.51277526
170MP0000538_abnormal_urinary_bladder0.50332265

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.35464652
2Myokymia (HP:0002411)6.11653873
3Eczematoid dermatitis (HP:0000976)5.59552477
4Focal seizures (HP:0007359)5.55859561
5Recurrent abscess formation (HP:0002722)5.47211520
6Recurrent bacterial skin infections (HP:0005406)5.36616902
7Atonic seizures (HP:0010819)4.97799469
8Abnormality of macrophages (HP:0004311)4.94156928
9Visual hallucinations (HP:0002367)4.76385611
10Myositis (HP:0100614)4.66658727
11Febrile seizures (HP:0002373)4.52171321
12Epileptic encephalopathy (HP:0200134)4.50529645
13Absence seizures (HP:0002121)4.40777531
14Recurrent gram-negative bacterial infections (HP:0005420)4.30262573
15Obstructive lung disease (HP:0006536)4.24752168
16Chronic obstructive pulmonary disease (HP:0006510)4.24752168
17Orchitis (HP:0100796)4.21350690
18Stomatitis (HP:0010280)4.09711339
19Progressive cerebellar ataxia (HP:0002073)4.04119513
20Generalized tonic-clonic seizures (HP:0002069)3.95945685
21Dialeptic seizures (HP:0011146)3.91285437
22Optic neuritis (HP:0100653)3.91164538
23Retrobulbar optic neuritis (HP:0100654)3.91164538
24Elevated erythrocyte sedimentation rate (HP:0003565)3.84004562
25Mediastinal lymphadenopathy (HP:0100721)3.83672321
26Polyphagia (HP:0002591)3.74145070
27Recurrent fungal infections (HP:0002841)3.71392115
28Recurrent skin infections (HP:0001581)3.71030680
29Broad-based gait (HP:0002136)3.64651227
30Meningitis (HP:0001287)3.63741484
31Hypochromic microcytic anemia (HP:0004840)3.56084217
32Amblyopia (HP:0000646)3.54322595
33Cellulitis (HP:0100658)3.48344432
34Supranuclear gaze palsy (HP:0000605)3.47753481
35Recurrent cutaneous fungal infections (HP:0011370)3.46672289
36Chronic mucocutaneous candidiasis (HP:0002728)3.46672289
37Abnormal eating behavior (HP:0100738)3.46129141
38Gingivitis (HP:0000230)3.37986587
39Ankle clonus (HP:0011448)3.30998797
40Limb dystonia (HP:0002451)3.29281084
41Mutism (HP:0002300)3.20785992
42Gastrointestinal infarctions (HP:0005244)3.20444933
43Impaired vibration sensation in the lower limbs (HP:0002166)3.16000925
44Poor eye contact (HP:0000817)3.12457731
45Hyperventilation (HP:0002883)3.11290461
46Episodic fever (HP:0001954)3.07850619
47Amyloidosis (HP:0011034)3.07812992
48Urticaria (HP:0001025)3.07278914
49Failure to thrive in infancy (HP:0001531)3.04162553
50Prolonged bleeding time (HP:0003010)3.03666100
51Progressive inability to walk (HP:0002505)3.01556756
52Spontaneous hematomas (HP:0007420)2.98349810
53Excessive salivation (HP:0003781)2.96772912
54Drooling (HP:0002307)2.96772912
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.90652554
56Encephalitis (HP:0002383)2.86017817
57Anxiety (HP:0000739)2.84844454
58Increased cerebral lipofuscin (HP:0011813)2.83950439
59Truncal ataxia (HP:0002078)2.83370118
60Chest pain (HP:0100749)2.81065430
61Action tremor (HP:0002345)2.80889862
62Vasculitis (HP:0002633)2.80297115
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.79932391
64Depression (HP:0000716)2.79549378
65Increased IgE level (HP:0003212)2.78604837
66Hypochromic anemia (HP:0001931)2.77282709
67Impaired social interactions (HP:0000735)2.74330275
68Abnormal social behavior (HP:0012433)2.74330275
69Keratoconjunctivitis sicca (HP:0001097)2.71339200
70Urinary bladder sphincter dysfunction (HP:0002839)2.68730457
71Hemiparesis (HP:0001269)2.64396764
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64049901
73Neuronal loss in central nervous system (HP:0002529)2.63649227
74Hemoptysis (HP:0002105)2.63065109
75Gaze-evoked nystagmus (HP:0000640)2.62858614
76Urinary urgency (HP:0000012)2.60792934
77Epileptiform EEG discharges (HP:0011182)2.57486122
78Dysmetria (HP:0001310)2.55634081
79Dysdiadochokinesis (HP:0002075)2.53321831
80Spastic gait (HP:0002064)2.51965945
81Papilledema (HP:0001085)2.49132545
82Petechiae (HP:0000967)2.47712168
83Insidious onset (HP:0003587)2.47323556
84Termporal pattern (HP:0011008)2.47323556
85Inability to walk (HP:0002540)2.46616377
86EEG with generalized epileptiform discharges (HP:0011198)2.45431061
87Abnormality of the corticospinal tract (HP:0002492)2.44681796
88Keratoconjunctivitis (HP:0001096)2.44430352
89Epistaxis (HP:0000421)2.43806612
90Esotropia (HP:0000565)2.43486816
91Cerebral inclusion bodies (HP:0100314)2.43143512
92Agitation (HP:0000713)2.40308193
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.39789890
94Loss of speech (HP:0002371)2.38885663
95Gait imbalance (HP:0002141)2.38532250
96Gingival bleeding (HP:0000225)2.38239877
97Pheochromocytoma (HP:0002666)2.36355187
98Neurofibrillary tangles (HP:0002185)2.35371123
99Abnormal hair whorl (HP:0010721)2.33428523
100Abnormality of glycolipid metabolism (HP:0010969)2.32053704
101Abnormality of liposaccharide metabolism (HP:0010968)2.32053704
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.32053704
103Fetal akinesia sequence (HP:0001989)2.31658473
104Protruding tongue (HP:0010808)2.31514422
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31302632
106Exotropia (HP:0000577)2.30722830
107Hypsarrhythmia (HP:0002521)2.27758763
108Specific learning disability (HP:0001328)2.27316144
109Amyotrophic lateral sclerosis (HP:0007354)2.26472077
110Pulmonary embolism (HP:0002204)2.23941195
111Osteomyelitis (HP:0002754)2.23023798
112Pulmonary infiltrates (HP:0002113)2.22796175
113Postural instability (HP:0002172)2.22738924
114Slow saccadic eye movements (HP:0000514)2.21645695
115Increased IgM level (HP:0003496)2.20738218
116Purpura (HP:0000979)2.20725740
117Torticollis (HP:0000473)2.18066273
118Poor suck (HP:0002033)2.17993101
119Hypoventilation (HP:0002791)2.16606911
120Hyperthyroidism (HP:0000836)2.16580046
121Abnormality of binocular vision (HP:0011514)2.15999484
122Diplopia (HP:0000651)2.15999484
123Sleep apnea (HP:0010535)2.15892735
124Stereotypic behavior (HP:0000733)2.14405506
125Lower limb muscle weakness (HP:0007340)2.14265278
126Gastrointestinal inflammation (HP:0004386)2.13835681
127Leukocytosis (HP:0001974)2.12814712
128Bradykinesia (HP:0002067)2.10792625
129Inflammation of the large intestine (HP:0002037)2.10748123
130Disinhibition (HP:0000734)2.10458830
131Hemiplegia (HP:0002301)2.10334237
132Megalencephaly (HP:0001355)2.10311465
133Hypoplasia of the brainstem (HP:0002365)2.09462791
134Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09462791
135Vertigo (HP:0002321)2.09228191
136Sepsis (HP:0100806)2.08988086
137Hepatosplenomegaly (HP:0001433)2.08918179
138Neuroendocrine neoplasm (HP:0100634)2.08689015
139Peritonitis (HP:0002586)2.08093654
140Scanning speech (HP:0002168)2.07598141
141Recurrent viral infections (HP:0004429)2.07234306
142Focal dystonia (HP:0004373)2.05997329
143Psychosis (HP:0000709)2.05972983
144Blue irides (HP:0000635)2.05172938
145Abnormality of the labia minora (HP:0012880)2.04559943
146Absent speech (HP:0001344)2.04448257
147Impaired smooth pursuit (HP:0007772)2.04279496
148Peripheral hypomyelination (HP:0007182)2.03835522
149Arterial thrombosis (HP:0004420)2.03103873
150Abnormality of the heme biosynthetic pathway (HP:0010472)2.02312128
151Akinesia (HP:0002304)2.01521439
152Genetic anticipation (HP:0003743)2.00638913
153Memory impairment (HP:0002354)1.98661230
154Abnormality of salivation (HP:0100755)1.97991792
155Panhypogammaglobulinemia (HP:0003139)1.97621763
156Narrow nasal bridge (HP:0000446)1.97546843
157Abnormality of the pleura (HP:0002103)1.96980627
158Agammaglobulinemia (HP:0004432)1.96091531
159Abnormality of the lower motor neuron (HP:0002366)1.95657035
160Microcytic anemia (HP:0001935)1.94702371
161Dysostosis multiplex (HP:0000943)1.94599500
162Generalized myoclonic seizures (HP:0002123)1.94062652
163Hypothermia (HP:0002045)1.91080147
164Status epilepticus (HP:0002133)1.90824634
165Craniofacial dystonia (HP:0012179)1.90003597
166Cheilitis (HP:0100825)1.89896053
167Annular pancreas (HP:0001734)1.88931027
168Abnormality of the peritoneum (HP:0002585)1.86725642
169Anorexia (HP:0002039)1.85128974
170Abnormality of the endocardium (HP:0004306)1.84066541
171Lissencephaly (HP:0001339)1.83931986
172Obstructive sleep apnea (HP:0002870)1.82908775
173Diminished motivation (HP:0000745)1.82901233
174Progressive macrocephaly (HP:0004481)1.82038896
175Delusions (HP:0000746)1.82036344
176Congenital primary aphakia (HP:0007707)1.81581174
177Rapidly progressive (HP:0003678)1.81350357
178Abnormality of ocular smooth pursuit (HP:0000617)1.80877993
179Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80644889
180Degeneration of the lateral corticospinal tracts (HP:0002314)1.80644889
181Impaired vibratory sensation (HP:0002495)1.80543357
182Acute necrotizing encephalopathy (HP:0006965)1.79721697
183Dynein arm defect of respiratory motile cilia (HP:0012255)1.78415080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.69353011
2MARK14.27013851
3MAP3K93.51534964
4MAP3K43.30071119
5EPHA43.27085374
6MAP4K13.16096377
7MAP3K122.93137155
8MAP2K72.88545960
9CASK2.83946469
10BLK2.79882349
11MAP3K112.75045411
12MINK12.62867458
13NTRK22.60666233
14ERN12.47490981
15MAP2K32.38613405
16IRAK42.30232080
17PNCK2.13616299
18TNIK2.10141274
19MAPK132.08652008
20MAP2K42.05613126
21DAPK22.01606856
22TYK21.90949755
23CSK1.90795431
24PAK61.89778736
25GRK61.67065662
26NTRK11.66225103
27KSR11.63654605
28CDK191.62864895
29BTK1.60396636
30SIK21.59614320
31ZAP701.57577902
32SYK1.56396422
33EPHB11.56237104
34UHMK11.47557030
35GRK51.47038700
36HCK1.46707400
37CDK51.45497474
38PLK21.38340361
39DAPK11.38075520
40MAP3K11.34466267
41KSR21.34458127
42ARAF1.34386770
43TESK21.30954335
44RIPK41.29655513
45MAP3K31.26417542
46JAK31.25107269
47PHKG11.20988282
48PHKG21.20988282
49CAMKK11.19402386
50CSF1R1.18525204
51PRKCG1.15595326
52JAK21.14644249
53LYN1.12040456
54PDK11.10845321
55WNK31.09871472
56TRIB31.09573481
57KIT1.08324835
58FES1.07639606
59MAPK121.07417036
60CAMK2A1.06261694
61PRPF4B1.04183209
62LATS21.02583342
63CAMKK21.02526209
64GRK71.00378913
65PAK30.98522982
66PRKD30.93204132
67OXSR10.92336390
68TYRO30.91204516
69ITK0.90431204
70CAMK2B0.90316732
71CDK180.89573013
72NME10.88756546
73TBK10.86750330
74LCK0.86420738
75CDK150.85451569
76CDK140.84822881
77TAOK20.82289169
78CSNK1G20.80941114
79JAK10.80760987
80DYRK20.78408809
81DYRK1A0.76655766
82STK110.73378714
83STK380.73271873
84SGK2230.73168734
85SGK4940.73168734
86CDK11A0.72796962
87MARK30.71107118
88TXK0.70754393
89DYRK1B0.69670660
90MAP3K20.66559103
91BCR0.66161167
92TEC0.65801823
93PRKD20.65771372
94CAMK10.65021730
95IKBKE0.64442252
96SIK30.64348058
97BCKDK0.64236343
98MATK0.63991988
99ADRBK20.63921551
100MAP3K140.62601799
101ADRBK10.62204011
102PTK60.61713007
103PRKCE0.57809490
104RET0.57713350
105LIMK10.56638578
106PRKCZ0.55930345
107SGK10.55845217
108CCNB10.55384528
109TNK20.55032736
110CAMK40.53945183
111LMTK20.53818222
112PTK2B0.53768800
113TESK10.53715995
114SGK30.52182553
115RAF10.51876142
116BMPR20.51803102
117MARK20.51152407
118TAOK30.50822614
119FGR0.50774719
120ERBB30.50363064
121CAMK1G0.50198769
122MAP3K70.47756630
123MAP3K50.47461953
124CAMK2D0.47268485
125BRAF0.47205172
126CAMK2G0.46815517
127YES10.46187205
128SGK20.46060478
129RPS6KC10.46011029
130RPS6KL10.46011029
131CSNK1G30.44022939
132FER0.43926060
133IRAK20.43576494
134MAP3K130.43088884
135PRKCQ0.43072906
136MAP3K60.41727999
137PRKCH0.40155133
138RPS6KA20.39863687
139RPS6KA30.39798955
140CAMK1D0.39273888
141TAOK10.39054910
142PRKG20.38191101
143CDC42BPA0.37458998
144FYN0.36839925
145AKT30.35820935
146ROCK20.34554186
147PRKACA0.34206524
148PDPK10.33817409
149MAPK100.33014676
150PRKCB0.32237621
151FGFR20.31948008
152DAPK30.31866834

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.38999366
2Synaptic vesicle cycle_Homo sapiens_hsa047213.49643943
3GABAergic synapse_Homo sapiens_hsa047272.78943338
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77291291
5Leishmaniasis_Homo sapiens_hsa051402.54938554
6Glutamatergic synapse_Homo sapiens_hsa047242.51995955
7Osteoclast differentiation_Homo sapiens_hsa043802.51128462
8Amphetamine addiction_Homo sapiens_hsa050312.51063552
9Circadian entrainment_Homo sapiens_hsa047132.50883678
10Olfactory transduction_Homo sapiens_hsa047402.50054740
11Long-term potentiation_Homo sapiens_hsa047202.49707782
12Morphine addiction_Homo sapiens_hsa050322.48108905
13Dopaminergic synapse_Homo sapiens_hsa047282.25235596
14Staphylococcus aureus infection_Homo sapiens_hsa051502.24125374
15Collecting duct acid secretion_Homo sapiens_hsa049662.13380160
16Taste transduction_Homo sapiens_hsa047422.12092613
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.10758671
18Tuberculosis_Homo sapiens_hsa051522.06267723
19B cell receptor signaling pathway_Homo sapiens_hsa046622.04520272
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02104713
21Cocaine addiction_Homo sapiens_hsa050301.92402469
22Serotonergic synapse_Homo sapiens_hsa047261.91912321
23Salivary secretion_Homo sapiens_hsa049701.89974082
24Cholinergic synapse_Homo sapiens_hsa047251.88025901
25Insulin secretion_Homo sapiens_hsa049111.87960876
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85067069
27Renin secretion_Homo sapiens_hsa049241.79410201
28Allograft rejection_Homo sapiens_hsa053301.75287443
29Graft-versus-host disease_Homo sapiens_hsa053321.73247986
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71248650
31Oxidative phosphorylation_Homo sapiens_hsa001901.71090660
32Long-term depression_Homo sapiens_hsa047301.68345040
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64541445
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64191913
35Gastric acid secretion_Homo sapiens_hsa049711.63254300
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63253694
37Acute myeloid leukemia_Homo sapiens_hsa052211.61905718
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60982337
39Oxytocin signaling pathway_Homo sapiens_hsa049211.59352215
40Autoimmune thyroid disease_Homo sapiens_hsa053201.59347239
41Cardiac muscle contraction_Homo sapiens_hsa042601.55813533
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54355133
43Calcium signaling pathway_Homo sapiens_hsa040201.50872523
44Chemokine signaling pathway_Homo sapiens_hsa040621.49256141
45Gap junction_Homo sapiens_hsa045401.44519269
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39136374
47Vibrio cholerae infection_Homo sapiens_hsa051101.38011229
48* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37274295
49Axon guidance_Homo sapiens_hsa043601.36030145
50Malaria_Homo sapiens_hsa051441.35963163
51Parkinsons disease_Homo sapiens_hsa050121.35877605
52Alzheimers disease_Homo sapiens_hsa050101.35767982
53GnRH signaling pathway_Homo sapiens_hsa049121.35407309
54Other glycan degradation_Homo sapiens_hsa005111.28554453
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26755429
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24517773
57Viral myocarditis_Homo sapiens_hsa054161.14339108
58Estrogen signaling pathway_Homo sapiens_hsa049151.13754204
59Toxoplasmosis_Homo sapiens_hsa051451.13182615
60Antigen processing and presentation_Homo sapiens_hsa046121.12232774
61T cell receptor signaling pathway_Homo sapiens_hsa046601.11661170
62Hematopoietic cell lineage_Homo sapiens_hsa046401.10068498
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09534147
64cAMP signaling pathway_Homo sapiens_hsa040241.09347097
65Platelet activation_Homo sapiens_hsa046111.06093879
66Asthma_Homo sapiens_hsa053101.03979220
67Influenza A_Homo sapiens_hsa051641.03572033
68Primary immunodeficiency_Homo sapiens_hsa053401.01921200
69Salmonella infection_Homo sapiens_hsa051321.01545398
70ErbB signaling pathway_Homo sapiens_hsa040121.01077978
71Lysosome_Homo sapiens_hsa041421.00995590
72Type II diabetes mellitus_Homo sapiens_hsa049301.00567354
73Legionellosis_Homo sapiens_hsa051340.97527310
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97339910
75Melanogenesis_Homo sapiens_hsa049160.97267847
76Huntingtons disease_Homo sapiens_hsa050160.96723950
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94341265
78Phototransduction_Homo sapiens_hsa047440.94314812
79Glioma_Homo sapiens_hsa052140.93871868
80Measles_Homo sapiens_hsa051620.91416093
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89900053
82Pertussis_Homo sapiens_hsa051330.88723105
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.86910314
84Shigellosis_Homo sapiens_hsa051310.85690491
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.85222185
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.84983855
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84904291
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84087557
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82003631
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81123916
91Chronic myeloid leukemia_Homo sapiens_hsa052200.79718972
92Oocyte meiosis_Homo sapiens_hsa041140.78714964
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.78145099
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.77402645
95Notch signaling pathway_Homo sapiens_hsa043300.75883878
96Prolactin signaling pathway_Homo sapiens_hsa049170.75281913
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74842229
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.73708699
99Hepatitis B_Homo sapiens_hsa051610.73070281
100Hepatitis C_Homo sapiens_hsa051600.71244464
101Herpes simplex infection_Homo sapiens_hsa051680.70473966
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68730717
103TNF signaling pathway_Homo sapiens_hsa046680.68120438
104Dilated cardiomyopathy_Homo sapiens_hsa054140.68017137
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.67727755
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.66665435
107MAPK signaling pathway_Homo sapiens_hsa040100.66503167
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66116147
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65940517
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64757733
111Thyroid hormone synthesis_Homo sapiens_hsa049180.62292697
112Pancreatic cancer_Homo sapiens_hsa052120.62242827
113Dorso-ventral axis formation_Homo sapiens_hsa043200.61875487
114Pancreatic secretion_Homo sapiens_hsa049720.60866418
115Alcoholism_Homo sapiens_hsa050340.59123954
116Prion diseases_Homo sapiens_hsa050200.58300511
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57167878
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54788998
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.54131780
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54042781
121Ras signaling pathway_Homo sapiens_hsa040140.53835995
122Choline metabolism in cancer_Homo sapiens_hsa052310.53578093
123Glucagon signaling pathway_Homo sapiens_hsa049220.52881389
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52583569
125VEGF signaling pathway_Homo sapiens_hsa043700.48029557
126Type I diabetes mellitus_Homo sapiens_hsa049400.47287597
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46560200
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45019735
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44690594
130Renal cell carcinoma_Homo sapiens_hsa052110.43439713
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.43035157
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42502705
133Wnt signaling pathway_Homo sapiens_hsa043100.42245878
134Circadian rhythm_Homo sapiens_hsa047100.41480321
135Rheumatoid arthritis_Homo sapiens_hsa053230.40503478
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39367505
137Phagosome_Homo sapiens_hsa041450.38491069
138Insulin signaling pathway_Homo sapiens_hsa049100.37611785
139Endometrial cancer_Homo sapiens_hsa052130.35922636
140Rap1 signaling pathway_Homo sapiens_hsa040150.35655872
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34252595
142Butanoate metabolism_Homo sapiens_hsa006500.32760254
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31924052
144Inositol phosphate metabolism_Homo sapiens_hsa005620.31854805
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30275474
146African trypanosomiasis_Homo sapiens_hsa051430.28868868
147Ovarian steroidogenesis_Homo sapiens_hsa049130.28581613
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27149720
149Endocytosis_Homo sapiens_hsa041440.25286563
150Colorectal cancer_Homo sapiens_hsa052100.24641232
151Non-small cell lung cancer_Homo sapiens_hsa052230.22809800

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