OPCML

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.67459014
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66965594
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.60333976
4neuron cell-cell adhesion (GO:0007158)5.54399737
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.48941133
6sodium ion export (GO:0071436)5.36215286
7locomotory exploration behavior (GO:0035641)5.31463417
8synaptic vesicle exocytosis (GO:0016079)5.28649788
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.25660655
10protein localization to synapse (GO:0035418)5.23057630
11regulation of glutamate receptor signaling pathway (GO:1900449)5.16195990
12glutamate secretion (GO:0014047)5.05189241
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.89486372
14glutamate receptor signaling pathway (GO:0007215)4.85014127
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81245606
16synaptic vesicle maturation (GO:0016188)4.80985197
17regulation of synaptic vesicle exocytosis (GO:2000300)4.80557458
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.77374025
19synaptic transmission, glutamatergic (GO:0035249)4.66466860
20exploration behavior (GO:0035640)4.62051694
21neuronal action potential propagation (GO:0019227)4.60217226
22presynaptic membrane assembly (GO:0097105)4.53587341
23neuron-neuron synaptic transmission (GO:0007270)4.47219775
24L-amino acid import (GO:0043092)4.37384844
25neurotransmitter-gated ion channel clustering (GO:0072578)4.35055839
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.30979536
27regulation of synaptic vesicle transport (GO:1902803)4.30762819
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.30511263
29postsynaptic membrane organization (GO:0001941)4.26674977
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.24596392
31presynaptic membrane organization (GO:0097090)4.13936466
32regulation of neuronal synaptic plasticity (GO:0048168)4.11140255
33neuronal ion channel clustering (GO:0045161)4.10337507
34neurotransmitter secretion (GO:0007269)4.09875095
35gamma-aminobutyric acid signaling pathway (GO:0007214)4.09282402
36potassium ion import (GO:0010107)4.01248787
37* neuron recognition (GO:0008038)3.99209282
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.96073703
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95218416
40amino acid import (GO:0043090)3.90622884
41axonal fasciculation (GO:0007413)3.84469927
42regulation of postsynaptic membrane potential (GO:0060078)3.80806745
43long-term memory (GO:0007616)3.80475242
44potassium ion homeostasis (GO:0055075)3.78372723
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.77934157
46long-term synaptic potentiation (GO:0060291)3.77407531
47positive regulation of synapse maturation (GO:0090129)3.77308829
48gamma-aminobutyric acid transport (GO:0015812)3.77063647
49cellular sodium ion homeostasis (GO:0006883)3.74544554
50dendritic spine morphogenesis (GO:0060997)3.74288502
51positive regulation of membrane potential (GO:0045838)3.70482348
52neuromuscular process controlling balance (GO:0050885)3.70263348
53layer formation in cerebral cortex (GO:0021819)3.70145490
54proline transport (GO:0015824)3.68107978
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67257424
56cell communication by electrical coupling (GO:0010644)3.66596891
57regulation of synapse structural plasticity (GO:0051823)3.65072351
58regulation of synaptic plasticity (GO:0048167)3.59570688
59axon ensheathment in central nervous system (GO:0032291)3.59449129
60central nervous system myelination (GO:0022010)3.59449129
61regulation of voltage-gated calcium channel activity (GO:1901385)3.54358683
62response to histamine (GO:0034776)3.53541200
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.53231522
64regulation of dendritic spine morphogenesis (GO:0061001)3.52441463
65startle response (GO:0001964)3.52100674
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51486472
67transmission of nerve impulse (GO:0019226)3.47945449
68synaptic vesicle endocytosis (GO:0048488)3.46645714
69negative regulation of dendrite morphogenesis (GO:0050774)3.45070748
70positive regulation of neurotransmitter secretion (GO:0001956)3.43811520
71neurotransmitter transport (GO:0006836)3.40735774
72regulation of neurotransmitter secretion (GO:0046928)3.39664640
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31064779
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29186251
75behavioral fear response (GO:0001662)3.28497041
76behavioral defense response (GO:0002209)3.28497041
77establishment of mitochondrion localization (GO:0051654)3.27984890
78cerebellar granule cell differentiation (GO:0021707)3.25044916
79regulation of ARF protein signal transduction (GO:0032012)3.24785310
80synapse assembly (GO:0007416)3.19190628
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19038447
82membrane depolarization (GO:0051899)3.18699502
83learning (GO:0007612)3.18288441
84regulation of dendritic spine development (GO:0060998)3.17397843
85innervation (GO:0060384)3.16852586
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16360785
87dendrite morphogenesis (GO:0048813)3.16295945
88regulation of vesicle fusion (GO:0031338)3.15917542
89positive regulation of neurotransmitter transport (GO:0051590)3.15505516
90cellular potassium ion homeostasis (GO:0030007)3.13607680
91neuromuscular process (GO:0050905)3.12402987
92regulation of neurotransmitter levels (GO:0001505)3.12352491
93cerebellar Purkinje cell differentiation (GO:0021702)3.12064680
94neuromuscular process controlling posture (GO:0050884)3.11992004
95regulation of synapse maturation (GO:0090128)3.11292406
96regulation of neurotransmitter transport (GO:0051588)3.11217565
97fear response (GO:0042596)3.10898250
98cell communication involved in cardiac conduction (GO:0086065)3.10670440
99positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10592272
100adult walking behavior (GO:0007628)3.08866390
101positive regulation of synapse assembly (GO:0051965)3.08520245
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08391124
103cell differentiation in hindbrain (GO:0021533)3.07677469
104neurotransmitter uptake (GO:0001504)3.07367411
105detection of calcium ion (GO:0005513)3.04564544
106acidic amino acid transport (GO:0015800)3.03196538
107synaptic transmission (GO:0007268)3.02796057
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02158024
109regulation of synaptic transmission (GO:0050804)3.01556549
110positive regulation of synaptic transmission (GO:0050806)3.00786319
111auditory behavior (GO:0031223)2.99913274
112membrane hyperpolarization (GO:0060081)2.97335849
113activation of protein kinase A activity (GO:0034199)2.97023354
114regulation of glutamate secretion (GO:0014048)2.96259382
115central nervous system projection neuron axonogenesis (GO:0021952)2.95909259
116membrane depolarization during action potential (GO:0086010)2.95618769
117behavioral response to cocaine (GO:0048148)2.94488473
118response to auditory stimulus (GO:0010996)2.93244281
119regulation of respiratory system process (GO:0044065)2.91708088
120positive regulation of dendritic spine development (GO:0060999)2.90353505
121mechanosensory behavior (GO:0007638)2.90133352
122synapse organization (GO:0050808)2.89088805
123cochlea development (GO:0090102)2.88518083
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.87931610
125negative regulation of neurotransmitter transport (GO:0051589)2.87929403
126vesicle transport along microtubule (GO:0047496)2.86907384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13829543
2* GBX2_23144817_ChIP-Seq_PC3_Human4.24001695
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12188624
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08313537
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98846822
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63658867
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59482250
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59482250
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.54776548
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51758784
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50963967
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.50453440
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42169195
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36077685
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.33571217
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32905803
17DROSHA_22980978_ChIP-Seq_HELA_Human2.21564174
18TAF15_26573619_Chip-Seq_HEK293_Human2.17401047
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14400341
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10899528
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.08629652
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.08387834
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08090372
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07693997
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06792582
26* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03805530
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03019533
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.00260434
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87465802
30SMAD4_21799915_ChIP-Seq_A2780_Human1.86444228
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84320062
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82890579
33* AR_21572438_ChIP-Seq_LNCaP_Human1.80519327
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78794924
35* P300_19829295_ChIP-Seq_ESCs_Human1.75225535
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69488415
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65354799
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63582406
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60081709
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55800397
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.53286325
42ZNF274_21170338_ChIP-Seq_K562_Hela1.51545497
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.50690531
44FUS_26573619_Chip-Seq_HEK293_Human1.47965463
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45463180
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.44165333
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44120740
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43842532
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42670163
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.41834354
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40735193
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40701804
53* AR_25329375_ChIP-Seq_VCAP_Human1.39968784
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39072220
55IGF1R_20145208_ChIP-Seq_DFB_Human1.38293875
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37610052
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37110500
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34839274
59* STAT3_23295773_ChIP-Seq_U87_Human1.33047478
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29866530
61RNF2_27304074_Chip-Seq_NSC_Mouse1.27225721
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27103251
63VDR_22108803_ChIP-Seq_LS180_Human1.25181999
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21209167
65TCF4_23295773_ChIP-Seq_U87_Human1.21168295
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.19764213
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.19284976
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18928432
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.17785060
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17004177
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16703424
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16507299
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15442525
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13774952
75* PRDM14_20953172_ChIP-Seq_ESCs_Human1.13556105
76* AR_19668381_ChIP-Seq_PC3_Human1.13477372
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13231204
78TP53_16413492_ChIP-PET_HCT116_Human1.12030670
79RUNX2_22187159_ChIP-Seq_PCA_Human1.11978419
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11715596
81ER_23166858_ChIP-Seq_MCF-7_Human1.10954364
82AHR_22903824_ChIP-Seq_MCF-7_Human1.10709265
83TP53_18474530_ChIP-ChIP_U2OS_Human1.09720786
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.09278906
85KDM2B_26808549_Chip-Seq_K562_Human1.07710228
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06830966
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06599466
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06564929
89JUN_21703547_ChIP-Seq_K562_Human1.06490013
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.06361818
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06318051
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06249409
93* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03439665
94* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03439665
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01034473
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.00232636
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99300075
98ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98894843
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98366919
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.97663037
101SOX9_26525672_Chip-Seq_HEART_Mouse0.96984422
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96423911
103* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96125588
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95884111
105* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95316280
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94415236
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94037656
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93834049
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.92278004
110* KDM2B_26808549_Chip-Seq_REH_Human0.91669657
111BCAT_22108803_ChIP-Seq_LS180_Human0.91145112
112P53_22387025_ChIP-Seq_ESCs_Mouse0.91003412
113CMYC_18555785_Chip-Seq_ESCs_Mouse0.90921040
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.90464830
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89141366
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88990526
117* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86907790
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85242873
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84074850
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83182783
121* SMAD4_21741376_ChIP-Seq_HESCs_Human0.83075906
122CTCF_27219007_Chip-Seq_Bcells_Human0.82629388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.19543565
2MP0003880_abnormal_central_pattern5.42337055
3MP0003635_abnormal_synaptic_transmissio4.16457525
4MP0004270_analgesia3.73700903
5MP0009745_abnormal_behavioral_response3.53862165
6MP0002063_abnormal_learning/memory/cond3.41807738
7MP0001968_abnormal_touch/_nociception3.30045394
8MP0002064_seizures3.21516676
9MP0009046_muscle_twitch3.13905628
10MP0002572_abnormal_emotion/affect_behav2.97915643
11MP0002736_abnormal_nociception_after2.72728174
12MP0002734_abnormal_mechanical_nocicepti2.67620515
13MP0002272_abnormal_nervous_system2.66754500
14MP0001486_abnormal_startle_reflex2.59598705
15MP0002735_abnormal_chemical_nociception2.56309109
16MP0005423_abnormal_somatic_nervous2.47421920
17MP0001501_abnormal_sleep_pattern2.47116320
18MP0001440_abnormal_grooming_behavior2.40547156
19MP0002067_abnormal_sensory_capabilities2.12116897
20MP0000778_abnormal_nervous_system2.06745903
21MP0002733_abnormal_thermal_nociception1.99539783
22MP0009780_abnormal_chondrocyte_physiolo1.95474003
23MP0001970_abnormal_pain_threshold1.93711659
24MP0002184_abnormal_innervation1.90576761
25MP0002557_abnormal_social/conspecific_i1.82769486
26MP0006276_abnormal_autonomic_nervous1.82720819
27MP0004924_abnormal_behavior1.78585670
28MP0005386_behavior/neurological_phenoty1.78585670
29MP0003329_amyloid_beta_deposits1.71817479
30MP0008569_lethality_at_weaning1.68647882
31MP0001529_abnormal_vocalization1.68135064
32MP0001188_hyperpigmentation1.66211958
33MP0005646_abnormal_pituitary_gland1.64003472
34MP0002822_catalepsy1.63734028
35MP0003879_abnormal_hair_cell1.63435701
36MP0003787_abnormal_imprinting1.63289444
37MP0004858_abnormal_nervous_system1.62097755
38MP0004811_abnormal_neuron_physiology1.59704246
39MP0001984_abnormal_olfaction1.57792431
40MP0005645_abnormal_hypothalamus_physiol1.50169406
41MP0000955_abnormal_spinal_cord1.49876772
42MP0004142_abnormal_muscle_tone1.40896424
43MP0002066_abnormal_motor_capabilities/c1.40323725
44MP0002882_abnormal_neuron_morphology1.40200102
45MP0001905_abnormal_dopamine_level1.40172711
46MP0003123_paternal_imprinting1.32524124
47MP0002909_abnormal_adrenal_gland1.22844238
48MP0004885_abnormal_endolymph1.22722732
49MP0003633_abnormal_nervous_system1.20083089
50MP0003122_maternal_imprinting1.16834063
51MP0001502_abnormal_circadian_rhythm1.16728000
52MP0004145_abnormal_muscle_electrophysio1.14302964
53MP0004742_abnormal_vestibular_system1.12099418
54MP0002152_abnormal_brain_morphology1.09295524
55MP0002837_dystrophic_cardiac_calcinosis1.08802563
56MP0003631_nervous_system_phenotype1.07351149
57MP0002876_abnormal_thyroid_physiology1.04285397
58MP0004147_increased_porphyrin_level1.00636459
59MP0001963_abnormal_hearing_physiology0.96503140
60MP0008872_abnormal_physiological_respon0.92538475
61MP0005551_abnormal_eye_electrophysiolog0.92491555
62MP0002069_abnormal_eating/drinking_beha0.90072001
63MP0002229_neurodegeneration0.89207286
64MP0000751_myopathy0.88043802
65MP0003121_genomic_imprinting0.87881948
66MP0008874_decreased_physiological_sensi0.87842994
67MP0004484_altered_response_of0.87533582
68MP0010386_abnormal_urinary_bladder0.87485448
69MP0005409_darkened_coat_color0.86825968
70MP0001348_abnormal_lacrimal_gland0.86676513
71MP0000569_abnormal_digit_pigmentation0.85640620
72MP0001986_abnormal_taste_sensitivity0.84902389
73MP0005171_absent_coat_pigmentation0.84370347
74MP0002638_abnormal_pupillary_reflex0.84352166
75MP0008877_abnormal_DNA_methylation0.83930408
76MP0004085_abnormal_heartbeat0.82624557
77MP0000631_abnormal_neuroendocrine_gland0.82103910
78MP0005623_abnormal_meninges_morphology0.80241424
79MP0002752_abnormal_somatic_nervous0.78773980
80MP0005535_abnormal_body_temperature0.78494737
81MP0003632_abnormal_nervous_system0.78212363
82MP0001177_atelectasis0.78019630
83MP0004215_abnormal_myocardial_fiber0.77979067
84MP0000920_abnormal_myelination0.75128353
85MP0003634_abnormal_glial_cell0.73797092
86MP0005394_taste/olfaction_phenotype0.73516605
87MP0005499_abnormal_olfactory_system0.73516605
88MP0001664_abnormal_digestion0.72904911
89MP0000604_amyloidosis0.71406522
90MP0001485_abnormal_pinna_reflex0.67690916
91MP0000026_abnormal_inner_ear0.66201337
92MP0002102_abnormal_ear_morphology0.65241063
93MP0006292_abnormal_olfactory_placode0.64823925
94MP0001299_abnormal_eye_distance/0.62354670
95MP0004130_abnormal_muscle_cell0.62278303
96MP0010768_mortality/aging0.60256882
97MP0004510_myositis0.58574234
98MP0004233_abnormal_muscle_weight0.58046443
99MP0003283_abnormal_digestive_organ0.57271381
100MP0005167_abnormal_blood-brain_barrier0.56618310
101MP0003690_abnormal_glial_cell0.56395877
102MP0003861_abnormal_nervous_system0.55444458
103MP0001943_abnormal_respiration0.55434875
104MP0003646_muscle_fatigue0.54094551
105MP0000013_abnormal_adipose_tissue0.52975166
106MP0003137_abnormal_impulse_conducting0.52579140
107MP0000579_abnormal_nail_morphology0.52481718
108MP0002082_postnatal_lethality0.51667159
109MP0010770_preweaning_lethality0.51667159
110MP0010769_abnormal_survival0.51403358
111MP0004043_abnormal_pH_regulation0.50982392
112MP0003956_abnormal_body_size0.50262901
113MP0003075_altered_response_to0.49253109
114MP0000015_abnormal_ear_pigmentation0.48899428
115MP0003938_abnormal_ear_development0.48774397
116MP0002090_abnormal_vision0.48512038
117MP0001346_abnormal_lacrimal_gland0.47268556

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.58140639
2Focal seizures (HP:0007359)5.93038429
3Myokymia (HP:0002411)5.87997703
4Epileptic encephalopathy (HP:0200134)5.59298855
5Atonic seizures (HP:0010819)5.16206972
6Febrile seizures (HP:0002373)5.02362240
7Visual hallucinations (HP:0002367)4.95103156
8Hyperventilation (HP:0002883)4.89364743
9Absence seizures (HP:0002121)4.48236814
10Progressive cerebellar ataxia (HP:0002073)4.40175457
11Broad-based gait (HP:0002136)4.26908388
12Dialeptic seizures (HP:0011146)4.18918943
13Generalized tonic-clonic seizures (HP:0002069)4.06825758
14Gaze-evoked nystagmus (HP:0000640)3.52822142
15Excessive salivation (HP:0003781)3.45225174
16Drooling (HP:0002307)3.45225174
17Poor eye contact (HP:0000817)3.37061908
18Action tremor (HP:0002345)3.25105507
19Supranuclear gaze palsy (HP:0000605)3.20314199
20Amblyopia (HP:0000646)3.18162379
21Absent speech (HP:0001344)3.16219917
22Impaired vibration sensation in the lower limbs (HP:0002166)3.08137940
23Dysdiadochokinesis (HP:0002075)3.03815905
24Truncal ataxia (HP:0002078)3.02753977
25Cerebral hypomyelination (HP:0006808)3.00552347
26Obstructive sleep apnea (HP:0002870)2.98064628
27Impaired social interactions (HP:0000735)2.93822767
28Abnormal social behavior (HP:0012433)2.93822767
29Dysmetria (HP:0001310)2.93543236
30Mutism (HP:0002300)2.91298444
31Epileptiform EEG discharges (HP:0011182)2.90215084
32Diplopia (HP:0000651)2.88720079
33Abnormality of binocular vision (HP:0011514)2.88720079
34Progressive inability to walk (HP:0002505)2.81438024
35Urinary bladder sphincter dysfunction (HP:0002839)2.81130945
36Cerebral inclusion bodies (HP:0100314)2.81129131
37Inability to walk (HP:0002540)2.79883284
38Abnormal eating behavior (HP:0100738)2.78276794
39Protruding tongue (HP:0010808)2.77717008
40Ankle clonus (HP:0011448)2.71890689
41Fetal akinesia sequence (HP:0001989)2.71244064
42Anxiety (HP:0000739)2.70693790
43Annular pancreas (HP:0001734)2.69239442
44Depression (HP:0000716)2.68526911
45Abnormality of the corticospinal tract (HP:0002492)2.64017972
46Neurofibrillary tangles (HP:0002185)2.63693094
47Hemiparesis (HP:0001269)2.63683163
48EEG with generalized epileptiform discharges (HP:0011198)2.63085974
49Craniofacial dystonia (HP:0012179)2.62807085
50Genetic anticipation (HP:0003743)2.62201752
51Scanning speech (HP:0002168)2.58402120
52Impaired smooth pursuit (HP:0007772)2.54729210
53Insidious onset (HP:0003587)2.51898138
54Termporal pattern (HP:0011008)2.51898138
55Sleep apnea (HP:0010535)2.50994356
56Polyphagia (HP:0002591)2.50493191
57Postural instability (HP:0002172)2.48068649
58Blue irides (HP:0000635)2.46469697
59Hypsarrhythmia (HP:0002521)2.42984171
60Apathy (HP:0000741)2.41703511
61Tetraplegia (HP:0002445)2.40284020
62Neuronal loss in central nervous system (HP:0002529)2.39075709
63Stereotypic behavior (HP:0000733)2.38933706
64Spastic gait (HP:0002064)2.37543257
65Abnormality of salivation (HP:0100755)2.36821543
66Gait imbalance (HP:0002141)2.34833473
67Urinary urgency (HP:0000012)2.31720637
68Papilledema (HP:0001085)2.29183529
69Akinesia (HP:0002304)2.27045465
70Bradykinesia (HP:0002067)2.26474005
71Generalized myoclonic seizures (HP:0002123)2.26376493
72Limb dystonia (HP:0002451)2.25053363
73Spastic tetraparesis (HP:0001285)2.21518377
74Morphological abnormality of the pyramidal tract (HP:0002062)2.19505656
75Abnormality of ocular smooth pursuit (HP:0000617)2.18378184
76Peripheral hypomyelination (HP:0007182)2.17372803
77Pheochromocytoma (HP:0002666)2.17292244
78Inappropriate behavior (HP:0000719)2.15695146
79Clonus (HP:0002169)2.15006685
80Diminished motivation (HP:0000745)2.14807727
81Fair hair (HP:0002286)2.13223425
82Abnormality of the lower motor neuron (HP:0002366)2.13215251
83Impaired vibratory sensation (HP:0002495)2.13096396
84Generalized hypopigmentation of hair (HP:0011358)2.12860493
85Status epilepticus (HP:0002133)2.11571110
86Amyotrophic lateral sclerosis (HP:0007354)2.11450547
87Lower limb muscle weakness (HP:0007340)2.06169210
88Megalencephaly (HP:0001355)2.04228758
89Torticollis (HP:0000473)2.04159064
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.02699145
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02699145
92Intention tremor (HP:0002080)1.99856464
93CNS hypomyelination (HP:0003429)1.98437587
94Focal dystonia (HP:0004373)1.97543616
95Widely spaced teeth (HP:0000687)1.94771481
96Dysmetric saccades (HP:0000641)1.91724294
97Neuroendocrine neoplasm (HP:0100634)1.91344799
98Gait ataxia (HP:0002066)1.90917951
99Specific learning disability (HP:0001328)1.90891743
100Insomnia (HP:0100785)1.88363905
101Rigidity (HP:0002063)1.87725909
102Delusions (HP:0000746)1.86928202
103Incomplete penetrance (HP:0003829)1.86813210
104Prolonged QT interval (HP:0001657)1.84993163
105Medial flaring of the eyebrow (HP:0010747)1.84501297
106Agitation (HP:0000713)1.83764192
107Hemiplegia (HP:0002301)1.83643569
108Absent/shortened dynein arms (HP:0200106)1.82989665
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.82989665
110Esotropia (HP:0000565)1.82345669
111Congenital primary aphakia (HP:0007707)1.81579399
112Hyperthyroidism (HP:0000836)1.81551460
113Spastic tetraplegia (HP:0002510)1.81198978
114Thickened helices (HP:0000391)1.80717141
115Exotropia (HP:0000577)1.80230658
116Clumsiness (HP:0002312)1.79771613
117Psychosis (HP:0000709)1.79233210
118Lower limb amyotrophy (HP:0007210)1.78032474
119Gastroesophageal reflux (HP:0002020)1.76924994
120Rapidly progressive (HP:0003678)1.74652395
121Abnormal EKG (HP:0003115)1.72649137
122Abnormality of saccadic eye movements (HP:0000570)1.72153369
123Memory impairment (HP:0002354)1.70814704
124Hypoplasia of the corpus callosum (HP:0002079)1.68971078
125Ventricular fibrillation (HP:0001663)1.65165065
126Lower limb asymmetry (HP:0100559)1.63499764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.52361959
2EPHA44.41107970
3CASK3.84523635
4MARK13.48094712
5MAP3K43.23835343
6MAP3K93.14847012
7MAP2K73.06173351
8MAP3K122.53937006
9MINK12.43360246
10DAPK22.41281485
11RIPK42.29085883
12MAP2K42.03201959
13PLK21.99780549
14NTRK21.91434840
15TNIK1.89354023
16DAPK11.78622087
17PRPF4B1.67154689
18MAPK131.66614553
19PAK61.65715266
20CDK191.59322667
21KSR11.56583944
22PNCK1.53029177
23KSR21.43800703
24SIK21.42892500
25CDK51.40897723
26GRK51.39107448
27FES1.38071508
28NTRK11.34083671
29PRKCG1.29190992
30CAMKK11.28367944
31BMPR21.20000284
32CAMK2A1.17992789
33OXSR11.04535314
34CCNB11.03778912
35RIPK11.03712513
36CAMK2B1.01854104
37ARAF1.01632852
38PTK2B0.96163466
39TYRO30.95016304
40PHKG10.94369819
41PHKG20.94369819
42AKT30.92101139
43CAMKK20.90083406
44UHMK10.87849788
45PRKD30.87474544
46ALK0.86935248
47MAP3K130.85275543
48NME10.81018354
49CDK180.80469083
50FGR0.79805707
51SGK4940.79779999
52SGK2230.79779999
53CAMK10.79651068
54STK380.77838332
55MAP3K20.77019783
56CDK150.76536398
57LATS20.76200779
58DYRK20.75995121
59CDK140.75582349
60SGK20.74887686
61FGFR20.73970324
62CSNK1G20.73614047
63SGK10.73096865
64DYRK1A0.71184643
65SIK30.70976066
66MAP3K60.70388100
67PRKCE0.69582720
68RAF10.68906005
69STK110.67229588
70CDK11A0.65520828
71WNK10.64014784
72GRK70.61794425
73PAK30.61387209
74RET0.57721497
75CAMK1G0.55325156
76MARK20.54983445
77CAMK2D0.54363043
78PINK10.53408019
79PKN10.50216064
80MUSK0.46884495
81WNK30.46589673
82TNK20.46559659
83SGK30.46287531
84PDK10.46069388
85PRKCZ0.45719931
86CAMK1D0.44811432
87FER0.44288042
88CAMK2G0.44082150
89NEK60.43502399
90PRKCH0.43072587
91PDPK10.42584252
92MAP3K110.42509166
93FYN0.42370680
94MAPK120.41840572
95CSNK1D0.41610471
96BCR0.41406217
97LIMK10.39635027
98RPS6KA30.38763816
99ERBB30.36216895
100PRKCA0.35825816
101ROCK20.34517563
102BRSK10.33718603
103BRAF0.33690683
104PRKCB0.33579877
105ADRBK20.32651708
106MAPK100.32477436
107MAP2K10.32065874
108CAMK40.31638536
109MAP3K10.31269441
110PRKACA0.31177151
111PRKG10.31112022
112CDK30.30852263
113DAPK30.30502660
114ADRBK10.30458344
115MAPK80.28602103
116CSNK1A1L0.27427815
117IRAK20.26470329
118RPS6KB10.26017263
119CSNK1A10.25529038

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.33853073
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27241055
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97088072
4Long-term potentiation_Homo sapiens_hsa047202.85644121
5Circadian entrainment_Homo sapiens_hsa047132.79758912
6Glutamatergic synapse_Homo sapiens_hsa047242.74957967
7GABAergic synapse_Homo sapiens_hsa047272.68341482
8Morphine addiction_Homo sapiens_hsa050322.61860986
9Amphetamine addiction_Homo sapiens_hsa050312.56915316
10Olfactory transduction_Homo sapiens_hsa047402.51413217
11Salivary secretion_Homo sapiens_hsa049702.24239640
12Dopaminergic synapse_Homo sapiens_hsa047282.21202913
13Taste transduction_Homo sapiens_hsa047422.03554887
14Collecting duct acid secretion_Homo sapiens_hsa049662.00205702
15Long-term depression_Homo sapiens_hsa047301.92926853
16Serotonergic synapse_Homo sapiens_hsa047261.92041139
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91690957
18Insulin secretion_Homo sapiens_hsa049111.86511587
19Cholinergic synapse_Homo sapiens_hsa047251.84399134
20Renin secretion_Homo sapiens_hsa049241.81898745
21Gastric acid secretion_Homo sapiens_hsa049711.80014996
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73285671
23Calcium signaling pathway_Homo sapiens_hsa040201.72236823
24Oxytocin signaling pathway_Homo sapiens_hsa049211.66625028
25Cocaine addiction_Homo sapiens_hsa050301.50693684
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50164723
27Axon guidance_Homo sapiens_hsa043601.38869093
28GnRH signaling pathway_Homo sapiens_hsa049121.37501182
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35039716
30Gap junction_Homo sapiens_hsa045401.33836591
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29606170
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25522729
33cAMP signaling pathway_Homo sapiens_hsa040241.25004394
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23178638
35Vibrio cholerae infection_Homo sapiens_hsa051101.18810081
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16444682
37Estrogen signaling pathway_Homo sapiens_hsa049151.08577815
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06740845
39Type II diabetes mellitus_Homo sapiens_hsa049301.05117741
40Vitamin B6 metabolism_Homo sapiens_hsa007501.04622910
41ErbB signaling pathway_Homo sapiens_hsa040121.03941814
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02649262
43Melanogenesis_Homo sapiens_hsa049161.00850259
44Glioma_Homo sapiens_hsa052141.00422738
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00050527
46Cardiac muscle contraction_Homo sapiens_hsa042600.97059974
47Phototransduction_Homo sapiens_hsa047440.93528883
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.91114227
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86464160
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83486585
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78809746
52Bile secretion_Homo sapiens_hsa049760.78626893
53Pancreatic secretion_Homo sapiens_hsa049720.77552456
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77538040
55Alzheimers disease_Homo sapiens_hsa050100.77054696
56Oocyte meiosis_Homo sapiens_hsa041140.75208249
57Choline metabolism in cancer_Homo sapiens_hsa052310.73989311
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73242979
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.70164321
60Oxidative phosphorylation_Homo sapiens_hsa001900.69790169
61Dorso-ventral axis formation_Homo sapiens_hsa043200.69541203
62MAPK signaling pathway_Homo sapiens_hsa040100.68880009
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66994548
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66105513
65Thyroid hormone synthesis_Homo sapiens_hsa049180.66022585
66Dilated cardiomyopathy_Homo sapiens_hsa054140.64012982
67Ras signaling pathway_Homo sapiens_hsa040140.60883726
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60167545
69African trypanosomiasis_Homo sapiens_hsa051430.54448028
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53317146
71VEGF signaling pathway_Homo sapiens_hsa043700.51600386
72Glucagon signaling pathway_Homo sapiens_hsa049220.51045964
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.51011999
74Rap1 signaling pathway_Homo sapiens_hsa040150.48663235
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47606072
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.46907209
77Wnt signaling pathway_Homo sapiens_hsa043100.46155406
78Rheumatoid arthritis_Homo sapiens_hsa053230.46148779
79Type I diabetes mellitus_Homo sapiens_hsa049400.46147179
80Alcoholism_Homo sapiens_hsa050340.44516806
81Fatty acid biosynthesis_Homo sapiens_hsa000610.41972710
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41636047
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41094101
84Prion diseases_Homo sapiens_hsa050200.39961790
85Inositol phosphate metabolism_Homo sapiens_hsa005620.39386481
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38326417
87Circadian rhythm_Homo sapiens_hsa047100.37996568
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37191413
89Ovarian steroidogenesis_Homo sapiens_hsa049130.35507676
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35460686
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35245979
92Parkinsons disease_Homo sapiens_hsa050120.34229757
93Mineral absorption_Homo sapiens_hsa049780.34057739
94Renal cell carcinoma_Homo sapiens_hsa052110.32900321
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31499458
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31455753
97Tight junction_Homo sapiens_hsa045300.30620008
98Phagosome_Homo sapiens_hsa041450.30114130
99Endometrial cancer_Homo sapiens_hsa052130.30000034
100Hippo signaling pathway_Homo sapiens_hsa043900.29281506
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28460168
102Huntingtons disease_Homo sapiens_hsa050160.28373446
103Endocytosis_Homo sapiens_hsa041440.27886444
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27409341
105mTOR signaling pathway_Homo sapiens_hsa041500.27231117
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26760466
107Insulin signaling pathway_Homo sapiens_hsa049100.26146370
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24909424
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22434988
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20486205
111AMPK signaling pathway_Homo sapiens_hsa041520.19248303
112Arginine biosynthesis_Homo sapiens_hsa002200.18586266
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16372145

Most similar genes based on co-expression Upload to Enrichr

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