OMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.56912760
2cytochrome complex assembly (GO:0017004)4.03864061
3DNA double-strand break processing (GO:0000729)3.57216917
4interkinetic nuclear migration (GO:0022027)3.50232638
5protein complex biogenesis (GO:0070271)3.35840509
6mitochondrial respiratory chain complex assembly (GO:0033108)3.30128557
7synapsis (GO:0007129)3.21999887
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15972773
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15972773
10regulation of protein glycosylation (GO:0060049)3.14846177
11cilium or flagellum-dependent cell motility (GO:0001539)3.12385371
12sulfur amino acid catabolic process (GO:0000098)3.06752317
13antigen processing and presentation of endogenous antigen (GO:0019883)3.02124151
14peptidyl-histidine modification (GO:0018202)2.94642041
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94008626
16heart process (GO:0003015)2.92124156
17heart contraction (GO:0060047)2.92124156
18response to interferon-beta (GO:0035456)2.88568863
19cellular ketone body metabolic process (GO:0046950)2.87099553
20phosphorylated carbohydrate dephosphorylation (GO:0046838)2.86845540
21inositol phosphate dephosphorylation (GO:0046855)2.86845540
22somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85454486
23isotype switching (GO:0045190)2.85454486
24somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85454486
25positive regulation of glycoprotein biosynthetic process (GO:0010560)2.85332808
26cellular response to interferon-beta (GO:0035458)2.85182472
27reciprocal DNA recombination (GO:0035825)2.81334535
28reciprocal meiotic recombination (GO:0007131)2.81334535
29inositol phosphate catabolic process (GO:0071545)2.81289565
30oxidative phosphorylation (GO:0006119)2.81150200
31dopamine transport (GO:0015872)2.80304893
32S-adenosylmethionine metabolic process (GO:0046500)2.80180777
33replication fork processing (GO:0031297)2.78250847
34NADH dehydrogenase complex assembly (GO:0010257)2.77674326
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77674326
36mitochondrial respiratory chain complex I assembly (GO:0032981)2.77674326
37water-soluble vitamin biosynthetic process (GO:0042364)2.75409314
38L-phenylalanine metabolic process (GO:0006558)2.75172121
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75172121
40protein prenylation (GO:0018342)2.74323637
41prenylation (GO:0097354)2.74323637
42cytidine deamination (GO:0009972)2.74093294
43cytidine metabolic process (GO:0046087)2.74093294
44cytidine catabolic process (GO:0006216)2.74093294
45polyketide metabolic process (GO:0030638)2.70083822
46doxorubicin metabolic process (GO:0044598)2.70083822
47daunorubicin metabolic process (GO:0044597)2.70083822
48mitochondrial DNA replication (GO:0006264)2.68907474
49regulation of B cell receptor signaling pathway (GO:0050855)2.68835791
50regulation of glucokinase activity (GO:0033131)2.68647478
51regulation of hexokinase activity (GO:1903299)2.68647478
52positive regulation of chemokine secretion (GO:0090197)2.67162812
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65821345
54axoneme assembly (GO:0035082)2.64917945
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64722732
56L-phenylalanine catabolic process (GO:0006559)2.64722732
57lactate metabolic process (GO:0006089)2.64512544
58positive regulation of granulocyte differentiation (GO:0030854)2.62867185
59adenosine metabolic process (GO:0046085)2.62858600
60polyol catabolic process (GO:0046174)2.62115084
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61610324
62DNA deamination (GO:0045006)2.61355633
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.59995034
64valine metabolic process (GO:0006573)2.59436457
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.58452069
66short-chain fatty acid metabolic process (GO:0046459)2.56728085
67mitochondrial RNA metabolic process (GO:0000959)2.56107891
68nucleotide transmembrane transport (GO:1901679)2.55965769
69recombinational repair (GO:0000725)2.55700156
70piRNA metabolic process (GO:0034587)2.55157716
71cilium movement (GO:0003341)2.54980809
72double-strand break repair via homologous recombination (GO:0000724)2.54769474
73IMP metabolic process (GO:0046040)2.53534930
74regulation of mitotic spindle checkpoint (GO:1903504)2.53512902
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53512902
76male meiosis I (GO:0007141)2.53253620
77tryptophan catabolic process (GO:0006569)2.52714818
78indole-containing compound catabolic process (GO:0042436)2.52714818
79indolalkylamine catabolic process (GO:0046218)2.52714818
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.50772885
81aromatic amino acid family catabolic process (GO:0009074)2.49222607
82centriole replication (GO:0007099)2.49020764
83organic cation transport (GO:0015695)2.48416255
84cellular glucuronidation (GO:0052695)2.46946782
85AMP metabolic process (GO:0046033)2.46683338
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46313840
87mannosylation (GO:0097502)2.46162595
88branched-chain amino acid metabolic process (GO:0009081)2.46047032
89tryptophan metabolic process (GO:0006568)2.46020568
90pinocytosis (GO:0006907)2.42397797
91platelet dense granule organization (GO:0060155)2.42017491
92ketone body metabolic process (GO:1902224)2.41472553
93fatty acid beta-oxidation (GO:0006635)2.41332213
94epithelial cilium movement (GO:0003351)2.40265018
95DNA catabolic process, exonucleolytic (GO:0000738)2.40036492
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.39221730
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.39221730
98cellular response to exogenous dsRNA (GO:0071360)2.39059425
99autophagic vacuole fusion (GO:0000046)2.38733227
100termination of RNA polymerase III transcription (GO:0006386)2.38372452
101transcription elongation from RNA polymerase III promoter (GO:0006385)2.38372452
102IMP biosynthetic process (GO:0006188)2.38128469
103lysine catabolic process (GO:0006554)2.37882548
104lysine metabolic process (GO:0006553)2.37882548
105glucose 6-phosphate metabolic process (GO:0051156)2.37689429
106rRNA methylation (GO:0031167)2.37688498
107histone mRNA catabolic process (GO:0071044)2.37560667
108ubiquinone metabolic process (GO:0006743)2.37546336
109electron transport chain (GO:0022900)2.36975445
110positive regulation of gamma-delta T cell activation (GO:0046645)2.36123792
111carnitine metabolic process (GO:0009437)2.36118861
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.35628637
113organelle membrane fusion (GO:0090174)2.35571218
114immunoglobulin mediated immune response (GO:0016064)2.35477784
115amino-acid betaine metabolic process (GO:0006577)2.35014044
116ATP synthesis coupled proton transport (GO:0015986)2.34031842
117energy coupled proton transport, down electrochemical gradient (GO:0015985)2.34031842
118regulation of chemokine secretion (GO:0090196)2.33828225
119regulation of mitochondrial translation (GO:0070129)2.33026471
120respiratory electron transport chain (GO:0022904)2.32642777
121purine-containing compound salvage (GO:0043101)2.32517060
122xenobiotic catabolic process (GO:0042178)2.32517043
123homocysteine metabolic process (GO:0050667)2.31717479
124fatty acid oxidation (GO:0019395)2.31634612
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.30352134
126kynurenine metabolic process (GO:0070189)2.30334920
127viral transcription (GO:0019083)2.29711094
128positive regulation of histone H3-K4 methylation (GO:0051571)2.29602854
129rRNA modification (GO:0000154)2.29011102
130lipopolysaccharide metabolic process (GO:0008653)2.28266558
131pseudouridine synthesis (GO:0001522)2.27884208
132cotranslational protein targeting to membrane (GO:0006613)2.27436657
133protein targeting to ER (GO:0045047)2.26052883
134translational termination (GO:0006415)2.25982535
135lipid oxidation (GO:0034440)2.25219817
136response to nitrosative stress (GO:0051409)2.25143994
137L-fucose catabolic process (GO:0042355)2.23375345
138fucose catabolic process (GO:0019317)2.23375345
139L-fucose metabolic process (GO:0042354)2.23375345
140negative regulation of JUN kinase activity (GO:0043508)2.23050620
141maturation of SSU-rRNA (GO:0030490)2.22707202
142telomere maintenance via semi-conservative replication (GO:0032201)2.22079134
143quinone biosynthetic process (GO:1901663)2.20744193
144ubiquinone biosynthetic process (GO:0006744)2.20744193
145glyoxylate metabolic process (GO:0046487)2.19655774
146positive regulation of interferon-alpha production (GO:0032727)2.19400594
147protein localization to endoplasmic reticulum (GO:0070972)2.18873635
148phospholipid efflux (GO:0033700)2.17884052
149regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.17722337
150telomere maintenance via recombination (GO:0000722)2.17516031
151glucuronate metabolic process (GO:0019585)2.16999606
152uronic acid metabolic process (GO:0006063)2.16999606
153hepatocyte apoptotic process (GO:0097284)2.16465476
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.15831689
155B cell mediated immunity (GO:0019724)2.14256392
156fatty acid catabolic process (GO:0009062)2.14096864
157positive regulation of B cell differentiation (GO:0045579)2.13254813
158pteridine-containing compound biosynthetic process (GO:0042559)2.12548895
159translational elongation (GO:0006414)2.12381433
160purine nucleobase biosynthetic process (GO:0009113)2.11504690
161establishment of protein localization to endoplasmic reticulum (GO:0072599)2.11087312
162proteasome assembly (GO:0043248)2.11015843
163reactive oxygen species biosynthetic process (GO:1903409)2.10919113
164sulfur amino acid metabolic process (GO:0000096)2.10372462
165pyrimidine ribonucleoside catabolic process (GO:0046133)2.10345149
166ribosomal small subunit biogenesis (GO:0042274)2.09833167
167chaperone mediated protein folding requiring cofactor (GO:0051085)2.08228390
168regulation of superoxide anion generation (GO:0032928)2.08093185
169serine family amino acid biosynthetic process (GO:0009070)2.07507355
170regulation of interferon-alpha production (GO:0032647)2.05435699
171nucleobase biosynthetic process (GO:0046112)2.04984225
172necroptotic process (GO:0070266)2.04847078
173signal peptide processing (GO:0006465)2.04025094
174flavonoid metabolic process (GO:0009812)2.03797419
175branched-chain amino acid catabolic process (GO:0009083)2.03359651
176cysteine metabolic process (GO:0006534)2.02926202
177regulation of interferon-beta biosynthetic process (GO:0045357)2.02896269
178negative regulation of phagocytosis (GO:0050765)2.01291602
179toxin transport (GO:1901998)2.00066919
180respiratory chain complex IV assembly (GO:0008535)1.99417838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.02317795
2E2F7_22180533_ChIP-Seq_HELA_Human4.31222582
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.38016451
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.82495724
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79454850
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74667111
7VDR_22108803_ChIP-Seq_LS180_Human2.62259463
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58778354
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58254937
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.49818519
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44523066
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.41852471
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.36182228
14GATA1_22025678_ChIP-Seq_K562_Human2.30638409
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.29877826
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29858317
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21961900
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.21377499
19ZNF274_21170338_ChIP-Seq_K562_Hela2.20857743
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19659346
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.18987385
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18515177
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17640478
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.16978185
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14043829
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.13838607
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.04142487
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01683716
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.93219591
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91231173
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.87117018
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84911158
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81144424
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.79976978
35* FUS_26573619_Chip-Seq_HEK293_Human1.78848327
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77009461
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76992420
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74945701
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71889598
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71604679
41VDR_23849224_ChIP-Seq_CD4+_Human1.71288513
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70300004
43IGF1R_20145208_ChIP-Seq_DFB_Human1.67697223
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66398502
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64936005
46EWS_26573619_Chip-Seq_HEK293_Human1.64908295
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.64426936
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63736336
49ER_23166858_ChIP-Seq_MCF-7_Human1.63429812
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63253099
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.62791807
52SCL_19346495_ChIP-Seq_HPC-7_Human1.62707958
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.61178286
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60029861
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59914313
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59372114
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.57863204
58* SPI1_23547873_ChIP-Seq_NB4_Human1.57248749
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56230172
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55347624
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54223154
62* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52741280
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51985005
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51360875
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47176685
66GATA3_26560356_Chip-Seq_TH2_Human1.47085945
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46240810
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45463008
69FOXP3_21729870_ChIP-Seq_TREG_Human1.44321429
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42118499
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41861513
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41459481
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41429710
74* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41370566
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41315242
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40233393
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39601111
78P300_19829295_ChIP-Seq_ESCs_Human1.39436806
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38503039
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37856477
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37530803
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36242731
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.30474491
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29781293
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.29689123
86NANOG_19829295_ChIP-Seq_ESCs_Human1.29683159
87SOX2_19829295_ChIP-Seq_ESCs_Human1.29683159
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28939770
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28900098
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28791892
91BCAT_22108803_ChIP-Seq_LS180_Human1.28154749
92AR_21909140_ChIP-Seq_LNCAP_Human1.27681351
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25499392
94TP53_22573176_ChIP-Seq_HFKS_Human1.23627190
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23034753
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21988817
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21901829
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21886618
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21828883
100AR_20517297_ChIP-Seq_VCAP_Human1.21561407
101* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21248461
102* FOXA1_25329375_ChIP-Seq_VCAP_Human1.21248461
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.19531110
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19130477
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18311164
106SALL4_22934838_ChIP-ChIP_CD34+_Human1.17709439
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16812396
108HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15875823
109DCP1A_22483619_ChIP-Seq_HELA_Human1.15471768
110ELK1_19687146_ChIP-ChIP_HELA_Human1.15128676
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14036502
112CDX2_22108803_ChIP-Seq_LS180_Human1.13449359
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12678609
114MYC_18940864_ChIP-ChIP_HL60_Human1.12316629
115MYB_26560356_Chip-Seq_TH1_Human1.11308263
116XRN2_22483619_ChIP-Seq_HELA_Human1.11071211
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.10792440
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10529950
119P53_22387025_ChIP-Seq_ESCs_Mouse1.10295948
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10144138
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10038726
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09491046
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09266853
124* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09216110
125* CBP_20019798_ChIP-Seq_JUKART_Human1.09216110
126RUNX1_22412390_ChIP-Seq_EML_Mouse1.09002012
127VDR_21846776_ChIP-Seq_THP-1_Human1.08100098
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08049048
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07723079
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07498016
131TAF15_26573619_Chip-Seq_HEK293_Human1.07281447
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07242015
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06793512
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06646224
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06420945
136* GABP_19822575_ChIP-Seq_HepG2_Human1.06269179
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05105040
138MYB_26560356_Chip-Seq_TH2_Human1.05031705
139P300_18555785_Chip-Seq_ESCs_Mouse1.04653402
140* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04603331
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.04069984
142MYC_22102868_ChIP-Seq_BL_Human1.04028797
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03538794
144E2F1_18555785_Chip-Seq_ESCs_Mouse1.03310730
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03178621
146OCT4_18555785_Chip-Seq_ESCs_Mouse1.02642013
147* PHF8_20622853_ChIP-Seq_HELA_Human1.02430597
148E2F1_21310950_ChIP-Seq_MCF-7_Human1.01608813
149CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01303960
150* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01069949
151SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00991029
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00666529
153SOX2_18555785_Chip-Seq_ESCs_Mouse1.00493853
154CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00195232
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99039740
156UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98932519
157* RBPJ_21746931_ChIP-Seq_IB4_Human0.98501478
158TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98466651
159CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98049063
160GBX2_23144817_ChIP-Seq_PC3_Human0.97549141
161* ETV1_20927104_ChIP-Seq_GIST48_Human0.97205527
162* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93628637
163KDM5A_27292631_Chip-Seq_BREAST_Human0.92032496
164* MAF_26560356_Chip-Seq_TH1_Human0.91636779
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91387928
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90982274
167STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89042898
168* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87853049
169MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87785017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.49468615
2MP0003806_abnormal_nucleotide_metabolis2.77013015
3MP0008875_abnormal_xenobiotic_pharmacok2.74161499
4MP0002139_abnormal_hepatobiliary_system2.70652051
5MP0008877_abnormal_DNA_methylation2.59840233
6MP0002396_abnormal_hematopoietic_system2.56141918
7MP0001835_abnormal_antigen_presentation2.51608073
8MP0005360_urolithiasis2.49526698
9MP0005085_abnormal_gallbladder_physiolo2.38135238
10MP0005365_abnormal_bile_salt2.37247029
11MP0003186_abnormal_redox_activity2.35049366
12MP0000372_irregular_coat_pigmentation2.29034843
13MP0009840_abnormal_foam_cell2.12713046
14MP0004147_increased_porphyrin_level1.98664690
15MP0009785_altered_susceptibility_to1.90012140
16MP0003724_increased_susceptibility_to1.87037345
17MP0005671_abnormal_response_to1.86354808
18MP0003786_premature_aging1.84502063
19MP0003787_abnormal_imprinting1.84226481
20MP0005058_abnormal_lysosome_morphology1.81849527
21MP0003191_abnormal_cellular_cholesterol1.78496958
22MP0001853_heart_inflammation1.72346058
23MP0005645_abnormal_hypothalamus_physiol1.71099190
24MP0001873_stomach_inflammation1.58867350
25MP0005174_abnormal_tail_pigmentation1.57696741
26MP0005025_abnormal_response_to1.57000637
27MP0002009_preneoplasia1.53932527
28MP0006035_abnormal_mitochondrial_morpho1.53894513
29MP0003436_decreased_susceptibility_to1.52214690
30MP0003646_muscle_fatigue1.51374670
31MP0003693_abnormal_embryo_hatching1.51140360
32MP0002277_abnormal_respiratory_mucosa1.49973037
33MP0000685_abnormal_immune_system1.49887362
34MP0002148_abnormal_hypersensitivity_rea1.49467924
35MP0001800_abnormal_humoral_immune1.49417745
36MP0006072_abnormal_retinal_apoptosis1.49188051
37MP0003763_abnormal_thymus_physiology1.48306573
38MP0001666_abnormal_nutrient_absorption1.46780877
39MP0002419_abnormal_innate_immunity1.45053832
40MP0010155_abnormal_intestine_physiology1.44790578
41MP0004043_abnormal_pH_regulation1.44510013
42MP0000013_abnormal_adipose_tissue1.43659765
43MP0008995_early_reproductive_senescence1.43204199
44MP0009697_abnormal_copulation1.43065763
45MP0002132_abnormal_respiratory_system1.42648944
46MP0006036_abnormal_mitochondrial_physio1.41698207
47MP0002166_altered_tumor_susceptibility1.39328006
48MP0002452_abnormal_antigen_presenting1.39266553
49MP0004782_abnormal_surfactant_physiolog1.38662910
50MP0005319_abnormal_enzyme/_coenzyme1.37085989
51MP0005636_abnormal_mineral_homeostasis1.36147315
52MP0005397_hematopoietic_system_phenotyp1.35524887
53MP0001545_abnormal_hematopoietic_system1.35524887
54MP0002723_abnormal_immune_serum1.34741456
55MP0005253_abnormal_eye_physiology1.34629404
56MP0000427_abnormal_hair_cycle1.32883168
57MP0008469_abnormal_protein_level1.31230569
58MP0002095_abnormal_skin_pigmentation1.31215574
59MP0005379_endocrine/exocrine_gland_phen1.30345272
60MP0001764_abnormal_homeostasis1.29871324
61MP0008057_abnormal_DNA_replication1.29732981
62MP0002693_abnormal_pancreas_physiology1.28614397
63MP0010094_abnormal_chromosome_stability1.28234138
64MP0010329_abnormal_lipoprotein_level1.27692360
65MP0005075_abnormal_melanosome_morpholog1.27471937
66MP0005310_abnormal_salivary_gland1.26804590
67MP0002102_abnormal_ear_morphology1.24591016
68MP0003252_abnormal_bile_duct1.24521928
69MP0002638_abnormal_pupillary_reflex1.24117043
70MP0000689_abnormal_spleen_morphology1.23423852
71MP0002405_respiratory_system_inflammati1.23278041
72MP0005551_abnormal_eye_electrophysiolog1.23109742
73MP0005464_abnormal_platelet_physiology1.22938746
74MP0002420_abnormal_adaptive_immunity1.22878156
75MP0001819_abnormal_immune_cell1.22751836
76MP0005000_abnormal_immune_tolerance1.21525191
77MP0001986_abnormal_taste_sensitivity1.20276112
78MP0000609_abnormal_liver_physiology1.19895655
79MP0001845_abnormal_inflammatory_respons1.19557254
80MP0004145_abnormal_muscle_electrophysio1.17993523
81MP0000490_abnormal_crypts_of1.17237961
82MP0000343_altered_response_to1.17148437
83MP0010307_abnormal_tumor_latency1.17044452
84MP0005387_immune_system_phenotype1.16846738
85MP0001790_abnormal_immune_system1.16846738
86MP0006054_spinal_hemorrhage1.16813159
87MP0002398_abnormal_bone_marrow1.15688335
88MP0005389_reproductive_system_phenotype1.15412107
89MP0008872_abnormal_physiological_respon1.13462210
90MP0001661_extended_life_span1.13318547
91MP0008007_abnormal_cellular_replicative1.12770040
92MP0005332_abnormal_amino_acid1.12733465
93MP0000465_gastrointestinal_hemorrhage1.12362573
94MP0000716_abnormal_immune_system1.11727849
95MP0004215_abnormal_myocardial_fiber1.11667979
96MP0002722_abnormal_immune_system1.11596313
97MP0002163_abnormal_gland_morphology1.11562975
98MP0004808_abnormal_hematopoietic_stem1.11446525
99MP0004084_abnormal_cardiac_muscle1.10802279
100MP0009764_decreased_sensitivity_to1.10771224
101MP0000015_abnormal_ear_pigmentation1.10260529
102MP0002877_abnormal_melanocyte_morpholog1.08108315
103MP0000749_muscle_degeneration1.08088038
104MP0002429_abnormal_blood_cell1.07811097
105MP0003828_pulmonary_edema1.06386100
106MP0009643_abnormal_urine_homeostasis1.05379821
107MP0003077_abnormal_cell_cycle1.05155857
108MP0005646_abnormal_pituitary_gland1.04721712
109MP0005408_hypopigmentation1.02150254
110MP0005584_abnormal_enzyme/coenzyme_acti1.02046387
111MP0004264_abnormal_extraembryonic_tissu1.01703742
112MP0000598_abnormal_liver_morphology1.00259309
113MP0002876_abnormal_thyroid_physiology1.00249073
114MP0002138_abnormal_hepatobiliary_system0.98575662
115MP0005266_abnormal_metabolism0.98023996
116MP0004957_abnormal_blastocyst_morpholog0.97894351
117MP0002938_white_spotting0.97231487
118MP0004484_altered_response_of0.96776463
119MP0005220_abnormal_exocrine_pancreas0.96500266
120MP0002006_tumorigenesis0.96465725
121MP0003011_delayed_dark_adaptation0.95945600
122MP0009333_abnormal_splenocyte_physiolog0.95844079
123MP0006082_CNS_inflammation0.95625547
124MP0002909_abnormal_adrenal_gland0.93603254
125MP0004019_abnormal_vitamin_homeostasis0.92922473
126MP0002160_abnormal_reproductive_system0.92855056
127MP0005084_abnormal_gallbladder_morpholo0.92705393
128MP0009763_increased_sensitivity_to0.92125615
129MP0005670_abnormal_white_adipose0.90645129
130MP0001765_abnormal_ion_homeostasis0.90222443
131MP0003279_aneurysm0.90159077
132MP0001919_abnormal_reproductive_system0.89685320
133MP0005451_abnormal_body_composition0.89360265
134MP0003656_abnormal_erythrocyte_physiolo0.88661109
135MP0010352_gastrointestinal_tract_polyps0.88484071
136MP0005395_other_phenotype0.86759628
137MP0010368_abnormal_lymphatic_system0.86627809
138MP0002837_dystrophic_cardiac_calcinosis0.85777985
139MP0003866_abnormal_defecation0.85485167
140MP0001929_abnormal_gametogenesis0.84888753
141MP0004947_skin_inflammation0.83918154
142MP0003566_abnormal_cell_adhesion0.82370939
143MP0008058_abnormal_DNA_repair0.82193810
144MP0003195_calcinosis0.81663432
145MP0003718_maternal_effect0.81534251
146MP0004036_abnormal_muscle_relaxation0.80294808
147MP0002019_abnormal_tumor_incidence0.79632114
148MP0002118_abnormal_lipid_homeostasis0.79346291
149MP0001944_abnormal_pancreas_morphology0.78702552
150MP0000383_abnormal_hair_follicle0.77950980

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)3.57026647
2Abnormality of fatty-acid metabolism (HP:0004359)3.40223912
3Thrombocytosis (HP:0001894)3.36700155
4Hypoglycemic coma (HP:0001325)3.30311644
5Pancreatic cysts (HP:0001737)3.19164120
6Hepatic necrosis (HP:0002605)3.12719292
7Abnormality of the renal cortex (HP:0011035)3.09500914
8Intrahepatic cholestasis (HP:0001406)3.05079352
9Pancreatic fibrosis (HP:0100732)3.02787023
10Dicarboxylic aciduria (HP:0003215)2.99552606
11Abnormality of dicarboxylic acid metabolism (HP:0010995)2.99552606
12Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98788936
13Nausea (HP:0002018)2.94576273
14Acute necrotizing encephalopathy (HP:0006965)2.91146641
15Recurrent abscess formation (HP:0002722)2.85757959
16Abnormality of midbrain morphology (HP:0002418)2.85196029
17Molar tooth sign on MRI (HP:0002419)2.85196029
18Progressive macrocephaly (HP:0004481)2.81451476
19Renal cortical cysts (HP:0000803)2.76682774
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71909113
21Abnormality of methionine metabolism (HP:0010901)2.68599316
22Aplastic anemia (HP:0001915)2.68293618
23True hermaphroditism (HP:0010459)2.67424971
24Petechiae (HP:0000967)2.66684782
25Recurrent bacterial skin infections (HP:0005406)2.64285944
26Pustule (HP:0200039)2.61613862
27Hyperammonemia (HP:0001987)2.58743630
28Thyroiditis (HP:0100646)2.57916514
29Proximal tubulopathy (HP:0000114)2.53826299
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51455273
31Abnormal mitochondria in muscle tissue (HP:0008316)2.51395676
32Systemic lupus erythematosus (HP:0002725)2.51092670
33Hypothermia (HP:0002045)2.50997746
34Abnormal number of erythroid precursors (HP:0012131)2.50162066
35Hepatocellular necrosis (HP:0001404)2.47815402
36Congenital stationary night blindness (HP:0007642)2.45799655
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45646347
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45646347
39IgM deficiency (HP:0002850)2.41430233
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40913693
41Rhabdomyolysis (HP:0003201)2.39988505
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39654513
43Nephronophthisis (HP:0000090)2.39014328
44Abnormality of the pons (HP:0007361)2.34359422
45Chronic hepatic failure (HP:0100626)2.34156554
46Hyperinsulinemic hypoglycemia (HP:0000825)2.32204703
47Cerebral palsy (HP:0100021)2.30866802
48Abnormality of cells of the erythroid lineage (HP:0012130)2.30091003
49Abnormal biliary tract physiology (HP:0012439)2.28595040
50Bile duct proliferation (HP:0001408)2.28595040
51Abnormal rod and cone electroretinograms (HP:0008323)2.28207321
52Xanthomatosis (HP:0000991)2.27029173
53Abnormality of chromosome stability (HP:0003220)2.26200745
54Increased muscle lipid content (HP:0009058)2.26138412
55Hypobetalipoproteinemia (HP:0003563)2.25902517
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.25414901
57Ketoacidosis (HP:0001993)2.23666928
58Abnormality of the intrinsic pathway (HP:0010989)2.23053610
59Type II lissencephaly (HP:0007260)2.22786988
60Elevated erythrocyte sedimentation rate (HP:0003565)2.18222823
61Chronic diarrhea (HP:0002028)2.18084447
62Prolonged partial thromboplastin time (HP:0003645)2.17605858
63Abnormal ciliary motility (HP:0012262)2.17233072
64Glycosuria (HP:0003076)2.16896510
65Abnormality of urine glucose concentration (HP:0011016)2.16896510
66Hypoplasia of the pons (HP:0012110)2.16742074
67Methylmalonic acidemia (HP:0002912)2.15747281
68Increased hepatocellular lipid droplets (HP:0006565)2.14770739
69Bronchiectasis (HP:0002110)2.14530438
70Increased serum lactate (HP:0002151)2.14431936
71Hyperbilirubinemia (HP:0002904)2.14393029
72Hypoglycemic seizures (HP:0002173)2.13147863
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.11910685
74Absent/shortened dynein arms (HP:0200106)2.11910685
75Abnormality of the renal medulla (HP:0100957)2.11799717
76Autoimmune hemolytic anemia (HP:0001890)2.09101759
77Abnormal respiratory motile cilium physiology (HP:0012261)2.08966168
78Abnormal protein N-linked glycosylation (HP:0012347)2.08745983
79Abnormal protein glycosylation (HP:0012346)2.08745983
80Abnormal glycosylation (HP:0012345)2.08745983
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08745983
82Cerebellar dysplasia (HP:0007033)2.06945023
83Vacuolated lymphocytes (HP:0001922)2.06002864
84Abolished electroretinogram (ERG) (HP:0000550)2.05904114
85Furrowed tongue (HP:0000221)2.05510671
86Abnormality of macular pigmentation (HP:0008002)2.05147633
87Metabolic acidosis (HP:0001942)2.04862204
88Severe combined immunodeficiency (HP:0004430)2.02806274
89Increased CSF lactate (HP:0002490)2.02444711
90Neoplasm of the adrenal gland (HP:0100631)2.02369464
91Eczematoid dermatitis (HP:0000976)2.01683909
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01555316
93Large for gestational age (HP:0001520)2.00786996
94Rhinitis (HP:0012384)2.00523966
95Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00510282
96Increased intramyocellular lipid droplets (HP:0012240)2.00242411
97Abnormal respiratory motile cilium morphology (HP:0005938)2.00048990
98Abnormal respiratory epithelium morphology (HP:0012253)2.00048990
99Recurrent gram-negative bacterial infections (HP:0005420)1.99003716
100Cerebral edema (HP:0002181)1.98935416
101Exercise-induced muscle cramps (HP:0003710)1.98889772
102Fat malabsorption (HP:0002630)1.97236117
103Lipid accumulation in hepatocytes (HP:0006561)1.97072338
104Medial flaring of the eyebrow (HP:0010747)1.96997408
105Lethargy (HP:0001254)1.96365077
106Lactic acidosis (HP:0003128)1.96147286
107Hyperglycinuria (HP:0003108)1.95717376
108Abnormality of T cell physiology (HP:0011840)1.94007731
109Tubulointerstitial nephritis (HP:0001970)1.93933320
110Hypolipoproteinemia (HP:0010981)1.93217222
111Myositis (HP:0100614)1.92714513
112Abnormality of the prostate (HP:0008775)1.92313890
113Hepatosplenomegaly (HP:0001433)1.92024448
114Joint hemorrhage (HP:0005261)1.91325611
115Male pseudohermaphroditism (HP:0000037)1.91124598
116Hypomagnesemia (HP:0002917)1.91116612
117Complement deficiency (HP:0004431)1.90537886
118Reduced antithrombin III activity (HP:0001976)1.89458649
119Acute hepatic failure (HP:0006554)1.89132334
120Palpitations (HP:0001962)1.87824837
121Abnormality of alanine metabolism (HP:0010916)1.87147917
122Hyperalaninemia (HP:0003348)1.87147917
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87147917
124Ventricular tachycardia (HP:0004756)1.87105562
125Abnormality of serum amino acid levels (HP:0003112)1.86663587
126Respiratory failure (HP:0002878)1.86303396
127Abnormality of B cell number (HP:0010975)1.85968809
128Abnormality of vitamin B metabolism (HP:0004340)1.85929524
129Ketosis (HP:0001946)1.85830602
130Abnormality of the common coagulation pathway (HP:0010990)1.85427020
131Mitochondrial inheritance (HP:0001427)1.85415653
132Myoglobinuria (HP:0002913)1.85158910
133Abnormal drinking behavior (HP:0030082)1.85052250
134Polydipsia (HP:0001959)1.85052250
135Increased serum ferritin (HP:0003281)1.84880350
136Attenuation of retinal blood vessels (HP:0007843)1.84835489
137IgG deficiency (HP:0004315)1.84211354
138Autoimmune thrombocytopenia (HP:0001973)1.83988877
139Oral leukoplakia (HP:0002745)1.83960167
140Reticulocytopenia (HP:0001896)1.83954584
141Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83350832
142Methylmalonic aciduria (HP:0012120)1.83039547
143Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.82077196
144Abnormality of iron homeostasis (HP:0011031)1.81899741
145Abnormality of the left ventricular outflow tract (HP:0011103)1.81678858
146Subaortic stenosis (HP:0001682)1.81678858
147Periodontitis (HP:0000704)1.81448698
148Hyperlipoproteinemia (HP:0010980)1.80898328
149Congenital hepatic fibrosis (HP:0002612)1.80709210
150Steatorrhea (HP:0002570)1.79797882
151Abnormality of pyrimidine metabolism (HP:0004353)1.79229960
152Conjugated hyperbilirubinemia (HP:0002908)1.78892013
153B lymphocytopenia (HP:0010976)1.77464679
154Pancytopenia (HP:0001876)1.76939790
155Type I transferrin isoform profile (HP:0003642)1.76580400
156Hypoalphalipoproteinemia (HP:0003233)1.76409320
157Lipoatrophy (HP:0100578)1.75953989
158Decreased central vision (HP:0007663)1.75728796
159Abnormality of T cells (HP:0002843)1.75661668
160Stomatitis (HP:0010280)1.75295209
161Abnormality of nucleobase metabolism (HP:0010932)1.75140252
162Hyperglycinemia (HP:0002154)1.75126184
163Neoplasm of the adrenal cortex (HP:0100641)1.74908071
164Abnormal spermatogenesis (HP:0008669)1.74439504
165Tubular atrophy (HP:0000092)1.74082530
166Exertional dyspnea (HP:0002875)1.73993937
167Deep venous thrombosis (HP:0002625)1.73574689
168Acute encephalopathy (HP:0006846)1.73505375
169Abnormality of purine metabolism (HP:0004352)1.73095397
170Abnormality of glycine metabolism (HP:0010895)1.70529382
171Abnormality of serine family amino acid metabolism (HP:0010894)1.70529382
172Right ventricular cardiomyopathy (HP:0011663)1.70405200
173Esophageal neoplasm (HP:0100751)1.70297721
174Neoplasm of head and neck (HP:0012288)1.70297721
175Poor head control (HP:0002421)1.70239075
176Neonatal death (HP:0003811)1.69857604
177Abnormality of transition element cation homeostasis (HP:0011030)1.69742965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.21786502
2BCKDK2.97182014
3BMPR1B2.35807976
4FLT32.26564389
5PIK3CA2.20407688
6MAP2K32.15378416
7KIT2.14668255
8TYK22.11378651
9IRAK42.10768885
10MAP4K22.05539090
11OXSR12.04422304
12MAP4K12.04023445
13TEC2.03782720
14TGFBR12.02396367
15TAOK31.95843545
16GRK11.94671226
17TGFBR21.93713314
18ADRBK21.91536746
19IRAK31.87594619
20PBK1.83882491
21NEK91.80934502
22STK101.73059552
23TLK11.70978909
24NME21.70902272
25ACVR1B1.69506289
26STK391.68821743
27TBK11.65645391
28MAP3K141.59357613
29MKNK21.55627743
30STK161.55125297
31WNK31.54865605
32ZAK1.51391180
33TXK1.50324346
34BTK1.49617615
35BMPR21.46145892
36MYLK1.45573719
37TIE11.44890672
38ZAP701.44412223
39JAK31.39740711
40PIM21.39340489
41EIF2AK11.38158647
42TSSK61.29521125
43PKN21.27247013
44OBSCN1.25468041
45MAP3K31.20005242
46CSF1R1.19702610
47ERBB31.18556220
48IKBKE1.14501220
49FRK1.13497956
50TTN1.12633093
51WEE11.11309391
52RPS6KB21.10862682
53KDR1.10159701
54MAP3K61.10036961
55MAP2K61.07815811
56STK241.06953714
57MST1R1.05002594
58IKBKB1.04730636
59WNK41.04330748
60RPS6KA40.99910874
61PIM10.98159131
62PDK20.96338016
63STK30.96134935
64VRK10.96017044
65EIF2AK20.95169716
66MAP3K110.94154319
67PLK30.91696003
68ITK0.91537532
69PIK3CG0.88093964
70EIF2AK30.87152509
71TAF10.84257625
72PHKG20.83005911
73PHKG10.83005911
74PINK10.82913929
75LRRK20.82133234
76CAMKK20.81948149
77TTK0.81920450
78PLK40.81730899
79NUAK10.80037182
80MAP3K20.79475798
81NLK0.79336417
82MATK0.79302663
83PTK2B0.78278237
84RPS6KA50.77555171
85JAK10.76969002
86STK40.75416502
87CSNK1G10.74179934
88AURKB0.73348847
89PRKG20.71834826
90INSRR0.71825080
91LYN0.71618271
92PRKAA20.71385460
93NEK10.70767782
94PRKCQ0.70494146
95PASK0.70378554
96TRIM280.69785729
97ATR0.69678532
98GRK60.69407694
99CDK190.69369237
100TRPM70.68525524
101FGFR20.68200575
102MAPK150.67723552
103PLK10.67542592
104LCK0.67235047
105CHUK0.66782015
106MARK30.64456448
107STK38L0.64067218
108GRK70.63038337
109NME10.62844131
110MAP2K20.62682277
111SYK0.62310145
112TNK20.62102220
113PTK60.61908222
114MAP3K80.61405742
115BUB10.61102352
116CDK40.60881829
117CDK80.60254134
118PRKCE0.60140526
119RIPK40.59585563
120RPS6KA60.59162387
121SRPK10.58258347
122IRAK10.56702173
123ABL20.56638276
124ATM0.54670355
125CDC70.54033748
126MAP3K50.53560289
127MAPKAPK50.53231423
128SCYL20.53108038
129ILK0.52490693
130RPS6KL10.51690682
131RPS6KC10.51690682
132CSNK1G30.51127300
133JAK20.50992621
134BRSK20.50622426
135CDK70.50159614
136FES0.50001929
137MKNK10.49495209
138TNIK0.48779464
139FGFR30.46980906
140PDK30.46902453
141PDK40.46902453
142MELK0.46644217
143ADRBK10.45981678
144MAP3K120.45735604
145FGFR40.45510966
146VRK20.45449200
147MUSK0.44310434
148FER0.44083964
149MAPK130.43091278
150PAK30.42069787
151MAP3K40.38980906

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.70929378
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39572281
3Sulfur relay system_Homo sapiens_hsa041222.34149683
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22605078
5DNA replication_Homo sapiens_hsa030302.10018223
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94880483
7Ribosome_Homo sapiens_hsa030101.87284237
8Selenocompound metabolism_Homo sapiens_hsa004501.85776074
9Fatty acid degradation_Homo sapiens_hsa000711.79941915
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.78686358
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77844860
12Caffeine metabolism_Homo sapiens_hsa002321.76309174
13One carbon pool by folate_Homo sapiens_hsa006701.68337868
14Folate biosynthesis_Homo sapiens_hsa007901.67647499
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66922632
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.65634674
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64314582
18Type I diabetes mellitus_Homo sapiens_hsa049401.58608803
19Propanoate metabolism_Homo sapiens_hsa006401.57198468
20Chemical carcinogenesis_Homo sapiens_hsa052041.56211603
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55265961
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52973115
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51943812
24Peroxisome_Homo sapiens_hsa041461.50270619
25Base excision repair_Homo sapiens_hsa034101.49401170
26Basal transcription factors_Homo sapiens_hsa030221.48938043
27Nitrogen metabolism_Homo sapiens_hsa009101.47301987
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45462657
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42253459
30Mismatch repair_Homo sapiens_hsa034301.41036604
31Starch and sucrose metabolism_Homo sapiens_hsa005001.40687464
32Tryptophan metabolism_Homo sapiens_hsa003801.39172781
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37357456
34Non-homologous end-joining_Homo sapiens_hsa034501.37247605
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36379675
36Homologous recombination_Homo sapiens_hsa034401.35180328
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34917624
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34397446
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33581902
40Protein export_Homo sapiens_hsa030601.33370348
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29910122
42Proteasome_Homo sapiens_hsa030501.27765160
43Staphylococcus aureus infection_Homo sapiens_hsa051501.26966077
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25616895
45Regulation of autophagy_Homo sapiens_hsa041401.23200973
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.19211674
47beta-Alanine metabolism_Homo sapiens_hsa004101.15662240
48Asthma_Homo sapiens_hsa053101.15640885
49Histidine metabolism_Homo sapiens_hsa003401.15398608
50Carbon metabolism_Homo sapiens_hsa012001.15187782
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14484802
52Autoimmune thyroid disease_Homo sapiens_hsa053201.12745238
53Graft-versus-host disease_Homo sapiens_hsa053321.10263717
54Galactose metabolism_Homo sapiens_hsa000521.10007893
55Allograft rejection_Homo sapiens_hsa053301.08048382
56Huntingtons disease_Homo sapiens_hsa050161.07541250
57Pyrimidine metabolism_Homo sapiens_hsa002401.07173526
58Pentose phosphate pathway_Homo sapiens_hsa000301.03048278
59Complement and coagulation cascades_Homo sapiens_hsa046101.02697673
60Glutathione metabolism_Homo sapiens_hsa004801.00699227
61Antigen processing and presentation_Homo sapiens_hsa046121.00334595
62Other glycan degradation_Homo sapiens_hsa005110.99434770
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.98845245
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96830951
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96167666
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95648739
67Primary immunodeficiency_Homo sapiens_hsa053400.95160713
68Fatty acid metabolism_Homo sapiens_hsa012120.93624463
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92310832
70Retinol metabolism_Homo sapiens_hsa008300.90147972
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.89613023
72Alzheimers disease_Homo sapiens_hsa050100.89117845
73Legionellosis_Homo sapiens_hsa051340.87975176
74RNA transport_Homo sapiens_hsa030130.87362967
75Fatty acid elongation_Homo sapiens_hsa000620.86958260
76Phototransduction_Homo sapiens_hsa047440.86370204
77Systemic lupus erythematosus_Homo sapiens_hsa053220.85658975
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85474041
79Biosynthesis of amino acids_Homo sapiens_hsa012300.83361499
80Fructose and mannose metabolism_Homo sapiens_hsa000510.83174525
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.82388847
82RNA polymerase_Homo sapiens_hsa030200.81815522
83ABC transporters_Homo sapiens_hsa020100.80816623
84Butanoate metabolism_Homo sapiens_hsa006500.80538743
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80443922
86Nucleotide excision repair_Homo sapiens_hsa034200.79289298
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79163860
88Circadian rhythm_Homo sapiens_hsa047100.79060183
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78946783
90Arachidonic acid metabolism_Homo sapiens_hsa005900.77756863
91Leishmaniasis_Homo sapiens_hsa051400.75471770
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.75031768
93Parkinsons disease_Homo sapiens_hsa050120.74821994
94PPAR signaling pathway_Homo sapiens_hsa033200.73379267
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73290640
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72296808
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71967528
98RNA degradation_Homo sapiens_hsa030180.71382650
99Olfactory transduction_Homo sapiens_hsa047400.71340501
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69840452
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.67734074
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67253233
103Herpes simplex infection_Homo sapiens_hsa051680.67240311
104Linoleic acid metabolism_Homo sapiens_hsa005910.65082424
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64922553
106Phenylalanine metabolism_Homo sapiens_hsa003600.63859372
107Oxidative phosphorylation_Homo sapiens_hsa001900.63563524
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62465758
109Ether lipid metabolism_Homo sapiens_hsa005650.60979534
110Arginine biosynthesis_Homo sapiens_hsa002200.60511492
111Metabolic pathways_Homo sapiens_hsa011000.59844141
112Arginine and proline metabolism_Homo sapiens_hsa003300.59492961
113Fat digestion and absorption_Homo sapiens_hsa049750.57628414
114Measles_Homo sapiens_hsa051620.56035374
115Spliceosome_Homo sapiens_hsa030400.55720758
116Vitamin digestion and absorption_Homo sapiens_hsa049770.54664287
117Vitamin B6 metabolism_Homo sapiens_hsa007500.54488776
118Hematopoietic cell lineage_Homo sapiens_hsa046400.53917249
119Pyruvate metabolism_Homo sapiens_hsa006200.53660270
120Tyrosine metabolism_Homo sapiens_hsa003500.53632958
121Purine metabolism_Homo sapiens_hsa002300.50860105
122Fanconi anemia pathway_Homo sapiens_hsa034600.49871592
123Cell cycle_Homo sapiens_hsa041100.49351170
124p53 signaling pathway_Homo sapiens_hsa041150.48781017
125Steroid biosynthesis_Homo sapiens_hsa001000.48208654
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47777100
127Sphingolipid metabolism_Homo sapiens_hsa006000.43710262
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42353416
129Rheumatoid arthritis_Homo sapiens_hsa053230.41627958

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