OLIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)7.55723089
2myelination (GO:0042552)7.22072595
3ensheathment of neurons (GO:0007272)7.21781858
4axon ensheathment (GO:0008366)7.21781858
5fatty acid elongation (GO:0030497)6.82800971
6oligodendrocyte differentiation (GO:0048709)5.57278371
7dermatan sulfate biosynthetic process (GO:0030208)5.35850045
8long-chain fatty acid biosynthetic process (GO:0042759)5.27169740
9astrocyte differentiation (GO:0048708)5.23778694
10negative regulation of neurotransmitter secretion (GO:0046929)5.21199671
11cellular potassium ion homeostasis (GO:0030007)5.20414773
12potassium ion import (GO:0010107)5.09368065
13dermatan sulfate metabolic process (GO:0030205)5.03209838
14positive regulation of oligodendrocyte differentiation (GO:0048714)4.93571705
15sodium ion export (GO:0071436)4.90828777
16exploration behavior (GO:0035640)4.90104723
17potassium ion homeostasis (GO:0055075)4.79906112
18synaptic vesicle maturation (GO:0016188)4.78660562
19creatine metabolic process (GO:0006600)4.76803099
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.66867946
21chondroitin sulfate catabolic process (GO:0030207)4.65045344
22negative regulation of neurotransmitter transport (GO:0051589)4.63112000
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61337151
24presynaptic membrane assembly (GO:0097105)4.56261794
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.54174622
26myelin maintenance (GO:0043217)4.53486920
27eye photoreceptor cell differentiation (GO:0001754)4.52680507
28photoreceptor cell differentiation (GO:0046530)4.52680507
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48272115
30presynaptic membrane organization (GO:0097090)4.45605462
31cholesterol biosynthetic process (GO:0006695)4.44401990
32asymmetric protein localization (GO:0008105)4.38603259
33positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.33689940
34apical protein localization (GO:0045176)4.33519271
35astrocyte development (GO:0014002)4.32186773
36synaptic vesicle exocytosis (GO:0016079)4.31508280
37neuron cell-cell adhesion (GO:0007158)4.31042221
38regulation of synaptic vesicle exocytosis (GO:2000300)4.30566757
39L-amino acid import (GO:0043092)4.18372056
40negative regulation of protein localization to cell surface (GO:2000009)4.16499391
41glycerophospholipid catabolic process (GO:0046475)4.15442238
42substantia nigra development (GO:0021762)4.15252587
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.12209781
44glutamate secretion (GO:0014047)4.08378671
45vocalization behavior (GO:0071625)4.07761194
46nephron tubule formation (GO:0072079)4.03719250
47positive regulation of osteoblast proliferation (GO:0033690)4.02751095
48neurotransmitter-gated ion channel clustering (GO:0072578)3.97198691
49adhesion of symbiont to host cell (GO:0044650)3.95553469
50virion attachment to host cell (GO:0019062)3.95553469
51peptidyl-tyrosine autophosphorylation (GO:0038083)3.91954958
52regulation of neuronal synaptic plasticity (GO:0048168)3.91078180
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89894887
54regulation of collateral sprouting (GO:0048670)3.88303817
55establishment of mitochondrion localization (GO:0051654)3.88244490
56acidic amino acid transport (GO:0015800)3.88170910
57sterol biosynthetic process (GO:0016126)3.84644554
58myelination in peripheral nervous system (GO:0022011)3.81784651
59peripheral nervous system axon ensheathment (GO:0032292)3.81784651
60negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.78970610
61amino acid import (GO:0043090)3.75323461
62synaptic transmission, glutamatergic (GO:0035249)3.66574942
63regulation of synapse structural plasticity (GO:0051823)3.66262215
64transmission of nerve impulse (GO:0019226)3.65399333
65regulation of short-term neuronal synaptic plasticity (GO:0048172)3.64721211
66regulation of synaptic vesicle transport (GO:1902803)3.64495920
67regulation of glutamate receptor signaling pathway (GO:1900449)3.62568491
68auditory behavior (GO:0031223)3.55915282
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.53966719
70neuromuscular process controlling balance (GO:0050885)3.52574829
71mechanosensory behavior (GO:0007638)3.52227390
72long-term synaptic potentiation (GO:0060291)3.52019811
73response to lipoprotein particle (GO:0055094)3.52009963
74negative regulation of axonogenesis (GO:0050771)3.50376806
75long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.48860383
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47832109
77neurotransmitter secretion (GO:0007269)3.47801940
78positive regulation of glial cell differentiation (GO:0045687)3.43863098
79positive regulation of gliogenesis (GO:0014015)3.41552807
80cerebellar Purkinje cell layer development (GO:0021680)3.40904177
81import into cell (GO:0098657)3.39162793
82isoprenoid biosynthetic process (GO:0008299)3.37330827
83cerebral cortex radially oriented cell migration (GO:0021799)3.36015343
84L-glutamate transport (GO:0015813)3.35783742
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.35736993
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31791709
87negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30897622
88regulation of neurotransmitter uptake (GO:0051580)3.28709104
89response to methylmercury (GO:0051597)3.26197304
90glutamate receptor signaling pathway (GO:0007215)3.25662152
91Leydig cell differentiation (GO:0033327)3.25544910
92protein palmitoylation (GO:0018345)3.24662843
93cellular sodium ion homeostasis (GO:0006883)3.24302601
94protein localization to synapse (GO:0035418)3.23961030
95adult walking behavior (GO:0007628)3.23411908
96negative regulation of axon extension (GO:0030517)3.23321289
97regulation of synaptic transmission, glutamatergic (GO:0051966)3.21037603
98regulation of axon regeneration (GO:0048679)3.20792766
99regulation of neuron projection regeneration (GO:0070570)3.20792766
100positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.17784569
101response to redox state (GO:0051775)3.16833307
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16556735
103glial cell differentiation (GO:0010001)3.16086590
104regulation of respiratory system process (GO:0044065)3.15418143
105cerebellar granule cell differentiation (GO:0021707)3.15125860
106regulation of ARF protein signal transduction (GO:0032012)3.13241103
107positive regulation of action potential (GO:0045760)3.12926719
108response to auditory stimulus (GO:0010996)3.12434828
109neuron projection regeneration (GO:0031102)3.11002353
110long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.10569177
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09459150
112regulation of synaptic plasticity (GO:0048167)3.07311369
113enteric nervous system development (GO:0048484)3.06334486
114cell communication by electrical coupling (GO:0010644)3.05284837
115neuronal ion channel clustering (GO:0045161)3.03982729
116cellular response to epinephrine stimulus (GO:0071872)3.03089806
117regulation of female receptivity (GO:0045924)3.02555866
118adenosine receptor signaling pathway (GO:0001973)3.02448609
119regulation of beta-amyloid formation (GO:1902003)3.02361605
120peripheral nervous system development (GO:0007422)3.01563663
121neurotransmitter transport (GO:0006836)3.00168268
122fatty-acyl-CoA biosynthetic process (GO:0046949)2.98627894
123cGMP-mediated signaling (GO:0019934)2.97620592
124amyloid precursor protein metabolic process (GO:0042982)2.96861272
125positive regulation of membrane potential (GO:0045838)2.96593522
126glycosylceramide metabolic process (GO:0006677)2.93939165
127gamma-aminobutyric acid transport (GO:0015812)2.93506092
128membrane hyperpolarization (GO:0060081)2.93282804
129membrane tubulation (GO:0097320)2.92985819
130limb bud formation (GO:0060174)2.92389192
131adhesion of symbiont to host (GO:0044406)2.92220778
132regulation of neurotransmitter levels (GO:0001505)2.90832479
133regulation of neurotransmitter transport (GO:0051588)2.90005055
134axon development (GO:0061564)2.87492518
135glial cell development (GO:0021782)2.86606068
136membrane assembly (GO:0071709)2.83080208
137negative regulation of JUN kinase activity (GO:0043508)2.81353431
138very long-chain fatty acid metabolic process (GO:0000038)2.81206049
139neuronal action potential propagation (GO:0019227)2.79610788
140regulation of oligodendrocyte differentiation (GO:0048713)2.79526050
141magnesium ion transport (GO:0015693)2.79186900
142L-serine transport (GO:0015825)2.78084707
143neural nucleus development (GO:0048857)2.76950281
144nerve growth factor signaling pathway (GO:0038180)2.73612213
145fatty-acyl-CoA metabolic process (GO:0035337)2.72540442
146regulation of gliogenesis (GO:0014013)2.71789573
147neurotransmitter catabolic process (GO:0042135)2.70467547
148neuron remodeling (GO:0016322)2.66145510
149peptidyl-cysteine modification (GO:0018198)2.65656096
150response to epinephrine (GO:0071871)2.64011415
151activated T cell proliferation (GO:0050798)2.62034956
152dendrite morphogenesis (GO:0048813)2.61359862
153positive regulation of neurological system process (GO:0031646)2.59877237
154locomotory exploration behavior (GO:0035641)2.55525470
155regulation of glial cell differentiation (GO:0045685)2.54251018
156cellular response to monoamine stimulus (GO:0071868)2.52006375
157cellular response to catecholamine stimulus (GO:0071870)2.52006375
158leukocyte migration involved in inflammatory response (GO:0002523)2.51943718
159neuron recognition (GO:0008038)2.51407900
160Sertoli cell development (GO:0060009)2.50864387
161dendritic spine morphogenesis (GO:0060997)2.50670985
162neurotransmitter uptake (GO:0001504)2.49453210
163lateral sprouting from an epithelium (GO:0060601)2.48895170
164acyl-CoA biosynthetic process (GO:0071616)2.45527826
165thioester biosynthetic process (GO:0035384)2.45527826
166nucleotide transmembrane transport (GO:1901679)2.41285689
167interleukin-6-mediated signaling pathway (GO:0070102)2.38476005
168ear development (GO:0043583)2.37872100
169axon ensheathment in central nervous system (GO:0032291)10.4833541
170central nervous system myelination (GO:0022010)10.4833541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.59508455
2EZH2_22144423_ChIP-Seq_EOC_Human3.00446385
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.81307984
4* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.67959412
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62648853
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59459461
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56871525
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.46108462
9AR_21572438_ChIP-Seq_LNCaP_Human2.39252258
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33270613
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33270613
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32179788
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24486836
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.23397363
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23316457
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14883743
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.12080612
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09199715
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08213793
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07496667
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05582215
22TAF15_26573619_Chip-Seq_HEK293_Human2.04522794
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03981014
24* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01899027
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95211749
26* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91391842
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89955269
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87959351
29DROSHA_22980978_ChIP-Seq_HELA_Human1.86751341
30* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74809022
31* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69326506
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67272432
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64984874
34KDM2B_26808549_Chip-Seq_K562_Human1.64393264
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.63961890
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62943853
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62916126
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.61450226
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.58645951
40ER_23166858_ChIP-Seq_MCF-7_Human1.56267555
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55521966
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.55126388
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.54383111
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50733657
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50040757
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48828495
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47328849
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45258544
49REST_21632747_ChIP-Seq_MESCs_Mouse1.42859740
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42755651
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42687342
52* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40343943
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38886203
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36359178
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34598500
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33772712
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33290263
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.33042164
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29178297
60VDR_22108803_ChIP-Seq_LS180_Human1.24288238
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23480693
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22568561
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22097005
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21930613
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.21164233
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.20968301
67LXR_22292898_ChIP-Seq_THP-1_Human1.19543238
68FUS_26573619_Chip-Seq_HEK293_Human1.18784911
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.18723154
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16934593
71SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.13729473
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13159339
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12731597
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12137908
75P300_19829295_ChIP-Seq_ESCs_Human1.11905020
76* REST_18959480_ChIP-ChIP_MESCs_Mouse1.11497439
77STAT3_23295773_ChIP-Seq_U87_Human1.10675401
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06656431
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.03756335
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03417102
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02946384
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.02553576
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02240524
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01877049
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00596281
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99787211
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99663395
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99663395
89CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99056891
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99013338
91SMAD4_21799915_ChIP-Seq_A2780_Human0.98986283
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98441820
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97458714
94POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97192036
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96381820
96BP1_19119308_ChIP-ChIP_Hs578T_Human0.95856019
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95663731
98ZNF274_21170338_ChIP-Seq_K562_Hela0.95243827
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95163214
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94364442
101SOX2_21211035_ChIP-Seq_LN229_Gbm0.94008719
102TCF4_23295773_ChIP-Seq_U87_Human0.93972135
103AR_19668381_ChIP-Seq_PC3_Human0.93940348
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93783862
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93782910
106EOMES_21245162_ChIP-Seq_HESCs_Human0.93450258
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.92838338
108KLF4_19829295_ChIP-Seq_ESCs_Human0.92750712
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92718144
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.92346427
111RNF2_27304074_Chip-Seq_NSC_Mouse0.92327682
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92264797
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.92234850
114CTCF_27219007_Chip-Seq_Bcells_Human0.92033110
115OCT4_19829295_ChIP-Seq_ESCs_Human0.91849969
116AHR_22903824_ChIP-Seq_MCF-7_Human0.91451519
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91113298
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90899896
119TAL1_26923725_Chip-Seq_HPCs_Mouse0.90556812
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90187407
121KDM2B_26808549_Chip-Seq_DND41_Human0.88645973
122RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88521423
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88125109
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88041270
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87954932
126CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87857542
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87317868
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87105773
129SMC4_20622854_ChIP-Seq_HELA_Human0.86738233
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86557561
131* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86443366
132* TP53_20018659_ChIP-ChIP_R1E_Mouse0.85238558
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84739301
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.84315457
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82722762
136TBL1_22424771_ChIP-Seq_293T_Human0.82656030
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81694906
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81147945
139* KDM2B_26808549_Chip-Seq_JURKAT_Human0.80972545
140DPY_21335234_ChIP-Seq_ESCs_Mouse0.80576825
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80571660
142TP53_23651856_ChIP-Seq_MEFs_Mouse0.80135242
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72469329
144MYC_19915707_ChIP-ChIP_AK7_Human0.70765042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.42451304
2MP0003880_abnormal_central_pattern4.25955238
3MP0004270_analgesia3.43558391
4MP0003690_abnormal_glial_cell3.20276734
5MP0004885_abnormal_endolymph3.05058434
6MP0004859_abnormal_synaptic_plasticity2.95093591
7MP0003950_abnormal_plasma_membrane2.86190991
8MP0003329_amyloid_beta_deposits2.64969489
9MP0003136_yellow_coat_color2.64323149
10MP0000778_abnormal_nervous_system2.63923550
11MP0005171_absent_coat_pigmentation2.62918905
12* MP0003634_abnormal_glial_cell2.61906448
13MP0001486_abnormal_startle_reflex2.59130081
14MP0004742_abnormal_vestibular_system2.56995187
15MP0005167_abnormal_blood-brain_barrier2.53069141
16MP0002272_abnormal_nervous_system2.50265635
17MP0004142_abnormal_muscle_tone2.49788001
18MP0002064_seizures2.46671834
19MP0001529_abnormal_vocalization2.36164685
20MP0001485_abnormal_pinna_reflex2.32297568
21MP0001905_abnormal_dopamine_level2.25609692
22MP0005423_abnormal_somatic_nervous2.24551363
23MP0003635_abnormal_synaptic_transmissio2.14158784
24MP0009745_abnormal_behavioral_response2.02744504
25MP0002653_abnormal_ependyma_morphology1.99133844
26MP0003632_abnormal_nervous_system1.87057676
27MP0003183_abnormal_peptide_metabolism1.83526931
28MP0005409_darkened_coat_color1.79750482
29MP0002734_abnormal_mechanical_nocicepti1.77844680
30MP0009046_muscle_twitch1.75932760
31MP0002229_neurodegeneration1.75457445
32MP0003879_abnormal_hair_cell1.70611145
33MP0010678_abnormal_skin_adnexa1.67505020
34MP0000462_abnormal_digestive_system1.66416453
35* MP0000955_abnormal_spinal_cord1.61848005
36MP0003075_altered_response_to1.56679503
37MP0002063_abnormal_learning/memory/cond1.54320051
38MP0000383_abnormal_hair_follicle1.53104991
39MP0005451_abnormal_body_composition1.51626683
40* MP0002882_abnormal_neuron_morphology1.50303687
41MP0002572_abnormal_emotion/affect_behav1.49937673
42MP0005410_abnormal_fertilization1.48282982
43MP0002067_abnormal_sensory_capabilities1.44078444
44MP0004134_abnormal_chest_morphology1.43665559
45MP0005623_abnormal_meninges_morphology1.43004387
46MP0001299_abnormal_eye_distance/1.42202391
47MP0001440_abnormal_grooming_behavior1.38708917
48MP0004381_abnormal_hair_follicle1.36476292
49MP0002066_abnormal_motor_capabilities/c1.36064058
50MP0005551_abnormal_eye_electrophysiolog1.30794956
51MP0008569_lethality_at_weaning1.30580869
52MP0001963_abnormal_hearing_physiology1.26649269
53MP0000604_amyloidosis1.24630970
54MP0003631_nervous_system_phenotype1.23861549
55MP0001986_abnormal_taste_sensitivity1.23039091
56MP0003787_abnormal_imprinting1.22391276
57MP0002752_abnormal_somatic_nervous1.21509355
58MP0001970_abnormal_pain_threshold1.17045823
59MP0000467_abnormal_esophagus_morphology1.15587278
60MP0002733_abnormal_thermal_nociception1.15451012
61MP0003172_abnormal_lysosome_physiology1.15085265
62MP0005386_behavior/neurological_phenoty1.12580470
63MP0004924_abnormal_behavior1.12580470
64MP0001968_abnormal_touch/_nociception1.11295837
65MP0002736_abnormal_nociception_after1.09074118
66MP0002909_abnormal_adrenal_gland1.09060455
67MP0003938_abnormal_ear_development1.08294821
68* MP0002152_abnormal_brain_morphology1.08039245
69MP0004130_abnormal_muscle_cell1.03825885
70MP0000747_muscle_weakness1.03748731
71MP0000647_abnormal_sebaceous_gland1.00233063
72MP0001661_extended_life_span0.99921329
73MP0004043_abnormal_pH_regulation0.98612037
74MP0003633_abnormal_nervous_system0.98133407
75MP0001346_abnormal_lacrimal_gland0.97994633
76MP0006276_abnormal_autonomic_nervous0.95675306
77MP0003937_abnormal_limbs/digits/tail_de0.94246957
78MP0000026_abnormal_inner_ear0.92894932
79MP0004858_abnormal_nervous_system0.91899961
80MP0005195_abnormal_posterior_eye0.91729838
81MP0002557_abnormal_social/conspecific_i0.89686845
82MP0002184_abnormal_innervation0.87717528
83MP0000566_synostosis0.87457655
84MP0005166_decreased_susceptibility_to0.86590055
85MP0000579_abnormal_nail_morphology0.85852109
86MP0000631_abnormal_neuroendocrine_gland0.85789170
87MP0000762_abnormal_tongue_morphology0.85107167
88MP0001177_atelectasis0.84569902
89MP0006072_abnormal_retinal_apoptosis0.84162788
90MP0009250_abnormal_appendicular_skeleto0.81419294
91MP0005645_abnormal_hypothalamus_physiol0.80438027
92MP0004811_abnormal_neuron_physiology0.79779731
93MP0002822_catalepsy0.78794517
94MP0004147_increased_porphyrin_level0.76273142
95MP0002638_abnormal_pupillary_reflex0.76239495
96MP0004145_abnormal_muscle_electrophysio0.75668917
97MP0008874_decreased_physiological_sensi0.75624135
98MP0002069_abnormal_eating/drinking_beha0.73742802
99MP0005253_abnormal_eye_physiology0.73039169
100MP0001502_abnormal_circadian_rhythm0.72848074
101* MP0003861_abnormal_nervous_system0.72255339
102MP0001851_eye_inflammation0.71787305
103MP0003806_abnormal_nucleotide_metabolis0.71684950
104MP0009278_abnormal_bone_marrow0.71631457
105MP0002735_abnormal_chemical_nociception0.71253482
106MP0008260_abnormal_autophagy0.70830436
107MP0005646_abnormal_pituitary_gland0.70205196
108MP0002090_abnormal_vision0.70131374
109MP0001943_abnormal_respiration0.69680192
110MP0001984_abnormal_olfaction0.65307629
111MP0005535_abnormal_body_temperature0.65096021
112MP0009780_abnormal_chondrocyte_physiolo0.63287653
113MP0001340_abnormal_eyelid_morphology0.63223773
114MP0004185_abnormal_adipocyte_glucose0.63094250
115MP0001501_abnormal_sleep_pattern0.63033927
116MP0005408_hypopigmentation0.62828817
117MP0001348_abnormal_lacrimal_gland0.61576644
118MP0009384_cardiac_valve_regurgitation0.58371085
119MP0002133_abnormal_respiratory_system0.57987230
120MP0002249_abnormal_larynx_morphology0.55355747
121MP0005595_abnormal_vascular_smooth0.53600398
122MP0005388_respiratory_system_phenotype0.52570094
123MP0001958_emphysema0.50157906
124MP0001731_abnormal_postnatal_growth0.48734168
125MP0010769_abnormal_survival0.48704536
126MP0003283_abnormal_digestive_organ0.47930525
127MP0003956_abnormal_body_size0.47314628
128MP0003123_paternal_imprinting0.46568722
129MP0010770_preweaning_lethality0.45053114
130MP0002082_postnatal_lethality0.45053114
131MP0009379_abnormal_foot_pigmentation0.44914505
132MP0010768_mortality/aging0.44895306
133MP0002089_abnormal_postnatal_growth/wei0.44220606
134MP0003137_abnormal_impulse_conducting0.43639104

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.24880148
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.24880148
3Neurofibrillary tangles (HP:0002185)6.16576240
4Sensory axonal neuropathy (HP:0003390)5.24293168
5Peripheral hypomyelination (HP:0007182)5.09219672
6Diplopia (HP:0000651)5.05311735
7Abnormality of binocular vision (HP:0011514)5.05311735
8Abnormality of the corticospinal tract (HP:0002492)4.79821075
9Parakeratosis (HP:0001036)4.57186255
10Cerebral inclusion bodies (HP:0100314)4.48885412
11Obstructive sleep apnea (HP:0002870)4.15950930
12Cerebral hypomyelination (HP:0006808)3.98839806
13Supranuclear gaze palsy (HP:0000605)3.87905171
14Hemiplegia (HP:0002301)3.78249520
15Spastic gait (HP:0002064)3.69122799
16Focal seizures (HP:0007359)3.67480056
17Abnormal auditory evoked potentials (HP:0006958)3.62918501
18Alacrima (HP:0000522)3.55501564
19Abnormal eating behavior (HP:0100738)3.54057719
20Onion bulb formation (HP:0003383)3.53037237
21Intention tremor (HP:0002080)3.44528121
22Akinesia (HP:0002304)3.41043182
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38904591
24Oligodactyly (hands) (HP:0001180)3.35995101
25Abnormality of the pulmonary veins (HP:0011718)3.29069622
26Myokymia (HP:0002411)3.23733420
27Dysmetria (HP:0001310)3.16960028
28Retinal dysplasia (HP:0007973)3.14278374
29Febrile seizures (HP:0002373)3.06442918
30Generalized tonic-clonic seizures (HP:0002069)3.06399381
31Megalencephaly (HP:0001355)3.04699378
32Hemiparesis (HP:0001269)3.03660065
33Insidious onset (HP:0003587)3.02707250
34Termporal pattern (HP:0011008)3.02707250
35Mutism (HP:0002300)3.01342292
36Hypoplastic pelvis (HP:0008839)3.00392542
37Ankle clonus (HP:0011448)2.96476973
38Spastic paraparesis (HP:0002313)2.96083687
39Absent septum pellucidum (HP:0001331)2.95626689
40Insomnia (HP:0100785)2.86020227
41Morphological abnormality of the inner ear (HP:0011390)2.85662768
42Split foot (HP:0001839)2.83178766
43Decreased lacrimation (HP:0000633)2.79697921
44Abnormality of cochlea (HP:0000375)2.78064262
45Premature skin wrinkling (HP:0100678)2.75856561
46Thickened helices (HP:0000391)2.75808024
47Leukodystrophy (HP:0002415)2.73117327
48Limb dystonia (HP:0002451)2.67476393
49Slow saccadic eye movements (HP:0000514)2.65885581
50Postural instability (HP:0002172)2.64755294
51Truncal ataxia (HP:0002078)2.60121828
52Anteriorly placed anus (HP:0001545)2.58387608
53Sleep apnea (HP:0010535)2.55967883
54Coronal craniosynostosis (HP:0004440)2.55614396
55Synostosis involving the elbow (HP:0003938)2.55154593
56Humeroradial synostosis (HP:0003041)2.55154593
57Septo-optic dysplasia (HP:0100842)2.54920280
58Apathy (HP:0000741)2.54222822
59Neuronal loss in central nervous system (HP:0002529)2.52901989
60Scanning speech (HP:0002168)2.51736544
61Increased circulating renin level (HP:0000848)2.51506215
62Papilledema (HP:0001085)2.51345940
63Abnormality of the septum pellucidum (HP:0007375)2.47423493
64Increased serum pyruvate (HP:0003542)2.46294401
65Abnormality of glycolysis (HP:0004366)2.46294401
66Rigidity (HP:0002063)2.45999180
67Clumsiness (HP:0002312)2.45013778
68Hypoplasia of the iris (HP:0007676)2.42436747
69CNS hypomyelination (HP:0003429)2.41795279
70Urinary bladder sphincter dysfunction (HP:0002839)2.41073123
71Pheochromocytoma (HP:0002666)2.40537143
72Aplasia involving bones of the extremities (HP:0009825)2.36597147
73Aplasia involving bones of the upper limbs (HP:0009823)2.36597147
74Aplasia of the phalanges of the hand (HP:0009802)2.36597147
75Truncus arteriosus (HP:0001660)2.36561939
76Torticollis (HP:0000473)2.32809848
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31015487
78Partial agenesis of the corpus callosum (HP:0001338)2.30672952
79Diminished motivation (HP:0000745)2.29733566
80Congenital ichthyosiform erythroderma (HP:0007431)2.28404981
81Depression (HP:0000716)2.27416736
82Relative macrocephaly (HP:0004482)2.23018421
83Abnormality of the diencephalon (HP:0010662)2.22083759
84Anxiety (HP:0000739)2.20879398
85Oligodactyly (HP:0012165)2.20819965
86Abnormality of the periventricular white matter (HP:0002518)2.20815189
87Lower limb muscle weakness (HP:0007340)2.19254904
88Rapidly progressive (HP:0003678)2.17794295
89Muscle fiber splitting (HP:0003555)2.17661919
90Absence seizures (HP:0002121)2.17631940
91Abnormality of the 4th metacarpal (HP:0010012)2.17339455
92Tetraplegia (HP:0002445)2.16604426
93Autoamputation (HP:0001218)2.13808485
94Ankyloglossia (HP:0010296)2.12869055
95White forelock (HP:0002211)2.12868119
96Bradykinesia (HP:0002067)2.11644134
97Cerebral hemorrhage (HP:0001342)2.11229454
98Overriding aorta (HP:0002623)2.10161810
99Neuroendocrine neoplasm (HP:0100634)2.08827792
100Cupped ear (HP:0000378)2.06156650
101Paraparesis (HP:0002385)2.05926077
102Patchy hypopigmentation of hair (HP:0011365)2.04760223
103Delusions (HP:0000746)2.04397357
104Esophageal atresia (HP:0002032)2.04328438
105Progressive cerebellar ataxia (HP:0002073)2.02116031
106Visual hallucinations (HP:0002367)2.01481257
107Action tremor (HP:0002345)2.01147952
108Spastic tetraparesis (HP:0001285)2.00917783
109Infantile muscular hypotonia (HP:0008947)2.00767207
110Hyporeflexia of lower limbs (HP:0002600)2.00433636
111Atonic seizures (HP:0010819)1.98931405
112Hypomagnesemia (HP:0002917)1.98710108
113Stridor (HP:0010307)1.98656797
114Metabolic alkalosis (HP:0200114)1.96871294
115Stereotypic behavior (HP:0000733)1.96681577
116Hyperacusis (HP:0010780)1.96587040
117Hyperparathyroidism (HP:0000843)1.96492133
118Chin dimple (HP:0010751)1.95824044
119Clonus (HP:0002169)1.93621036
120Polyphagia (HP:0002591)1.93609124
121Dialeptic seizures (HP:0011146)1.93404768
122Urethral obstruction (HP:0000796)1.92278828
123Anomalous pulmonary venous return (HP:0010772)1.92207103
124Urinary incontinence (HP:0000020)1.90831624
125Bowel incontinence (HP:0002607)1.90631493
126Segmental peripheral demyelination/remyelination (HP:0003481)1.90269635
127Elfin facies (HP:0004428)1.89834100
128Adrenal hypoplasia (HP:0000835)1.89243992
129Axonal loss (HP:0003447)1.89218964
130Urinary urgency (HP:0000012)1.87482553
131Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87160208
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85373168
133Turricephaly (HP:0000262)1.84869792
134Partial duplication of thumb phalanx (HP:0009944)1.84357971
135Abnormality of the middle phalanges of the toes (HP:0010183)1.83402350
136Foot dorsiflexor weakness (HP:0009027)1.82734534
137Type II lissencephaly (HP:0007260)1.82596196
138Annular pancreas (HP:0001734)1.82078821
139Diminished movement (HP:0002374)1.81528826
140Hypokalemic alkalosis (HP:0001949)1.80571590
141Decreased motor nerve conduction velocity (HP:0003431)1.79457766
142Abnormal large intestine physiology (HP:0012700)1.79160937
143Choreoathetosis (HP:0001266)1.78557199
144Abnormality of the foot musculature (HP:0001436)1.78288504
145Barrel-shaped chest (HP:0001552)1.76630646
146Hyperventilation (HP:0002883)1.76179261
147Distal sensory impairment (HP:0002936)1.75907096
148Morphological abnormality of the pyramidal tract (HP:0002062)1.75881156
149Hammertoe (HP:0001765)1.75151870
150Methylmalonic acidemia (HP:0002912)1.74704702
151Generalized myoclonic seizures (HP:0002123)1.73969831
152Focal dystonia (HP:0004373)1.73846100
153Poor speech (HP:0002465)1.73822678
154Dementia (HP:0000726)1.73500122
155Epileptic encephalopathy (HP:0200134)1.71724695
156Memory impairment (HP:0002354)1.71304149
157Steppage gait (HP:0003376)1.67050921
158Dysdiadochokinesis (HP:0002075)1.65929348
159Focal motor seizures (HP:0011153)1.65849239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.71545621
2OXSR14.32449567
3EPHB13.01253600
4TNIK2.85632287
5TNK22.85182105
6CDK192.82388829
7BCR2.64256964
8PKN12.36003204
9ICK2.27656930
10LIMK12.17794590
11WNK42.17493828
12MET2.14188258
13PBK2.12929670
14NEK62.09643960
15CSNK1G31.98884709
16TYRO31.92268496
17FGFR21.90366975
18CSNK1A1L1.88950718
19UHMK11.85827380
20CASK1.83656221
21DAPK21.83373651
22PAK61.82969546
23NTRK11.82814843
24MAPKAPK51.79639604
25WNK11.74431753
26PRPF4B1.65189232
27ROCK21.64851600
28TESK21.59783074
29EPHA41.59501972
30PNCK1.58398949
31CAMKK11.56225837
32CSNK1G21.55793067
33CSNK1G11.54785647
34MARK11.49374012
35FGR1.48298415
36SGK21.45529980
37CAMK2B1.36863195
38RIPK11.35446396
39RIPK41.31208528
40CLK11.17098048
41CAMK2D1.15047654
42SIK21.14152811
43CDK141.10825918
44SGK31.10636535
45ERBB41.09299615
46PAK31.08389769
47MAPK121.01018962
48PINK10.99128096
49CDK150.98839938
50NTRK20.96069815
51CDK50.95295998
52SGK10.94287057
53PHKG20.93994023
54PHKG10.93994023
55CDK180.92671741
56IRAK20.92008642
57PDGFRA0.91701337
58CAMK2G0.91504337
59CDK11A0.90919035
60PLK20.87441138
61SGK2230.87393242
62SGK4940.87393242
63ALK0.82694741
64PDGFRB0.81916029
65DYRK20.79892058
66PRKCG0.79864175
67PRKCQ0.77985482
68CAMK2A0.76769710
69CAMK10.75619407
70KSR20.75456650
71ARAF0.75171554
72MUSK0.73953342
73FES0.73176807
74MAPK150.70514941
75MARK20.69883828
76LMTK20.69499193
77RAF10.68665235
78MST40.67078211
79STK380.65973665
80PRKD10.64605142
81FYN0.64474549
82IRAK10.63814942
83BMX0.63578936
84PRKCZ0.63133445
85GRK50.61733681
86CSNK1D0.56789611
87PRKCE0.56492332
88PDPK10.55656567
89PRKCH0.53225153
90STK110.52582894
91MAPK130.51096325
92CAMK40.50713965
93JAK20.50308915
94PIK3CA0.50176750
95MAP2K40.48469568
96PRKD30.48080151
97NTRK30.48037210
98PDK10.47552556
99CAMK1G0.44893646
100MAP3K130.43892106
101ROCK10.43292136
102RPS6KA30.43276198
103DMPK0.42537806
104PRKG10.41243463
105MAP3K90.40171747
106GSK3A0.39100064
107DYRK1A0.38611508
108DDR20.37867521
109MAP3K10.37390226
110CSNK1A10.37248823
111JAK10.36783528
112PAK10.35889025
113MOS0.34335930
114CDK30.34333615
115PRKACB0.34284928
116RPS6KB10.33591768
117BMPR20.32202772
118BMPR1B0.31644337
119MAP2K10.31186732
120KSR10.30573187
121RPS6KA50.30206114
122TRPM70.29587884
123MAP3K110.29535441
124MAPK40.28616183
125MAPK100.28358605
126INSR0.27386560
127PRKG20.26690203
128ERBB20.26241135
129MKNK10.26202762
130CSK0.25182327
131MINK10.24856697
132MAPK70.24142855
133MAP3K20.23307830
134SRC0.23048312
135RET0.21907636

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.04308268
2Steroid biosynthesis_Homo sapiens_hsa001004.56595272
3Fatty acid elongation_Homo sapiens_hsa000623.94361061
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.66782951
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.76646465
6Ether lipid metabolism_Homo sapiens_hsa005652.73028772
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.68923465
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60862368
9Insulin secretion_Homo sapiens_hsa049112.39700485
10Axon guidance_Homo sapiens_hsa043602.15633065
11Nitrogen metabolism_Homo sapiens_hsa009102.03604734
12Sulfur metabolism_Homo sapiens_hsa009201.87292415
13Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.69261173
14Sphingolipid metabolism_Homo sapiens_hsa006001.67700967
15Vitamin B6 metabolism_Homo sapiens_hsa007501.62073543
16Butanoate metabolism_Homo sapiens_hsa006501.60609055
17Oxidative phosphorylation_Homo sapiens_hsa001901.55554490
18Glutamatergic synapse_Homo sapiens_hsa047241.54736148
19GABAergic synapse_Homo sapiens_hsa047271.53761917
20Estrogen signaling pathway_Homo sapiens_hsa049151.50477787
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50418419
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40749638
23Renal cell carcinoma_Homo sapiens_hsa052111.37077363
24Bile secretion_Homo sapiens_hsa049761.33122874
25Glioma_Homo sapiens_hsa052141.32196692
26Protein export_Homo sapiens_hsa030601.29323936
27Serotonergic synapse_Homo sapiens_hsa047261.28495157
28Long-term depression_Homo sapiens_hsa047301.20649230
29Notch signaling pathway_Homo sapiens_hsa043301.18548751
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17175042
31Morphine addiction_Homo sapiens_hsa050321.16686066
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15703055
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14215096
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11490697
35Linoleic acid metabolism_Homo sapiens_hsa005911.11228941
36Tight junction_Homo sapiens_hsa045301.10866850
37Parkinsons disease_Homo sapiens_hsa050121.10602865
38GnRH signaling pathway_Homo sapiens_hsa049121.09697800
39Alzheimers disease_Homo sapiens_hsa050101.07706870
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05483789
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05454334
42Arginine and proline metabolism_Homo sapiens_hsa003301.05299189
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.03447985
44Sphingolipid signaling pathway_Homo sapiens_hsa040711.02352687
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01579320
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.00409195
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99187985
48Nicotine addiction_Homo sapiens_hsa050330.97090638
49Cocaine addiction_Homo sapiens_hsa050300.95310971
50Circadian entrainment_Homo sapiens_hsa047130.94086633
51Taste transduction_Homo sapiens_hsa047420.93247155
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92820004
53Fatty acid metabolism_Homo sapiens_hsa012120.92312864
54Endocytosis_Homo sapiens_hsa041440.91606438
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91603837
56ErbB signaling pathway_Homo sapiens_hsa040120.91037465
57Histidine metabolism_Homo sapiens_hsa003400.90839274
58beta-Alanine metabolism_Homo sapiens_hsa004100.89596745
59Vibrio cholerae infection_Homo sapiens_hsa051100.87567277
60VEGF signaling pathway_Homo sapiens_hsa043700.87559906
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86882819
62Rap1 signaling pathway_Homo sapiens_hsa040150.83335730
63Thyroid hormone synthesis_Homo sapiens_hsa049180.82689963
64Dorso-ventral axis formation_Homo sapiens_hsa043200.81837135
65Endometrial cancer_Homo sapiens_hsa052130.81126687
66Cardiac muscle contraction_Homo sapiens_hsa042600.79811909
67Dopaminergic synapse_Homo sapiens_hsa047280.79451891
68Salivary secretion_Homo sapiens_hsa049700.79068295
69Cholinergic synapse_Homo sapiens_hsa047250.77571584
70Ras signaling pathway_Homo sapiens_hsa040140.77159149
71Synaptic vesicle cycle_Homo sapiens_hsa047210.75950328
72Fatty acid biosynthesis_Homo sapiens_hsa000610.75912589
73Gastric acid secretion_Homo sapiens_hsa049710.75490692
74Hedgehog signaling pathway_Homo sapiens_hsa043400.75081955
75Gap junction_Homo sapiens_hsa045400.74962377
76Collecting duct acid secretion_Homo sapiens_hsa049660.74531145
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73470768
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71393219
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67756066
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.66585953
81Inositol phosphate metabolism_Homo sapiens_hsa005620.65519943
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61423153
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.59809839
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59399652
85Choline metabolism in cancer_Homo sapiens_hsa052310.59373288
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59034650
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58930015
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58639702
89Non-small cell lung cancer_Homo sapiens_hsa052230.58279649
90Olfactory transduction_Homo sapiens_hsa047400.57764086
91Ovarian steroidogenesis_Homo sapiens_hsa049130.57391505
92Phototransduction_Homo sapiens_hsa047440.56563250
93Propanoate metabolism_Homo sapiens_hsa006400.54826799
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54760958
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54249198
96mTOR signaling pathway_Homo sapiens_hsa041500.53959873
97Amphetamine addiction_Homo sapiens_hsa050310.52796786
98Prion diseases_Homo sapiens_hsa050200.52758917
99Renin secretion_Homo sapiens_hsa049240.52483059
100Type II diabetes mellitus_Homo sapiens_hsa049300.52440207
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51195320
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49471529
103Huntingtons disease_Homo sapiens_hsa050160.49011615
104cAMP signaling pathway_Homo sapiens_hsa040240.49011488
105Chemokine signaling pathway_Homo sapiens_hsa040620.48891996
106Glutathione metabolism_Homo sapiens_hsa004800.47809915
107Lysosome_Homo sapiens_hsa041420.46532194
108Rheumatoid arthritis_Homo sapiens_hsa053230.46360866
109Circadian rhythm_Homo sapiens_hsa047100.46245041
110Pancreatic secretion_Homo sapiens_hsa049720.46193105
111Chronic myeloid leukemia_Homo sapiens_hsa052200.44682816
112PPAR signaling pathway_Homo sapiens_hsa033200.43540926
113Colorectal cancer_Homo sapiens_hsa052100.42927380
114Oxytocin signaling pathway_Homo sapiens_hsa049210.42708607
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42678685
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42664135
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42405637
118Autoimmune thyroid disease_Homo sapiens_hsa053200.42380306
119ECM-receptor interaction_Homo sapiens_hsa045120.41866984
120Long-term potentiation_Homo sapiens_hsa047200.41602660
121AMPK signaling pathway_Homo sapiens_hsa041520.39746658
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38829200
123Wnt signaling pathway_Homo sapiens_hsa043100.38550767
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38431988
125Melanogenesis_Homo sapiens_hsa049160.37472173
126Oocyte meiosis_Homo sapiens_hsa041140.37357390
127Alcoholism_Homo sapiens_hsa050340.35906994
128Arachidonic acid metabolism_Homo sapiens_hsa005900.35433119
129MAPK signaling pathway_Homo sapiens_hsa040100.33847323
130Basal cell carcinoma_Homo sapiens_hsa052170.33475978
131Prolactin signaling pathway_Homo sapiens_hsa049170.33048223
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32840900
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.32793214
134Phagosome_Homo sapiens_hsa041450.32407845
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32275405
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31596526
137Calcium signaling pathway_Homo sapiens_hsa040200.31269845
138Platelet activation_Homo sapiens_hsa046110.31030551
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30582983
140Osteoclast differentiation_Homo sapiens_hsa043800.27629983

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