OLFML1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.04027422
2central nervous system myelination (GO:0022010)9.04027422
3keratan sulfate catabolic process (GO:0042340)6.84928766
4peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.72531476
5glomerular basement membrane development (GO:0032836)6.04364417
6L-phenylalanine catabolic process (GO:0006559)5.88446074
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.88446074
8fatty acid elongation (GO:0030497)5.86223874
9metanephric mesenchyme development (GO:0072075)5.79547184
10kidney mesenchyme development (GO:0072074)5.48026915
11cell migration involved in heart development (GO:0060973)5.35122834
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.20807955
13L-phenylalanine metabolic process (GO:0006558)5.20807955
14collagen fibril organization (GO:0030199)4.91309856
15myelin maintenance (GO:0043217)4.77828731
16extracellular fibril organization (GO:0043206)4.76554932
17mesenchymal-epithelial cell signaling (GO:0060638)4.63806433
18protein heterotrimerization (GO:0070208)4.61620436
19myelination (GO:0042552)4.49630030
20ensheathment of neurons (GO:0007272)4.47815579
21axon ensheathment (GO:0008366)4.47815579
22glomerular filtration (GO:0003094)4.36792783
23very long-chain fatty acid metabolic process (GO:0000038)4.17680206
24smooth muscle tissue development (GO:0048745)4.06054612
25fibril organization (GO:0097435)4.05557582
26aromatic amino acid family catabolic process (GO:0009074)4.04950880
27sequestering of extracellular ligand from receptor (GO:0035581)4.00998169
28positive regulation of gastrulation (GO:2000543)4.00285824
29alpha-linolenic acid metabolic process (GO:0036109)3.95192957
30regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.87885151
31long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.81251272
32bone trabecula formation (GO:0060346)3.79534896
33heme transport (GO:0015886)3.76763242
34L-serine metabolic process (GO:0006563)3.76058802
35renal filtration (GO:0097205)3.75976090
36fatty-acyl-CoA biosynthetic process (GO:0046949)3.67803861
37collagen metabolic process (GO:0032963)3.67270982
38collagen catabolic process (GO:0030574)3.65709331
39response to methylmercury (GO:0051597)3.64561729
40bile acid biosynthetic process (GO:0006699)3.63719439
41cell proliferation involved in metanephros development (GO:0072203)3.63257560
42dermatan sulfate biosynthetic process (GO:0030208)3.61019129
43regulation of lipoprotein metabolic process (GO:0050746)3.57917871
44fatty-acyl-CoA metabolic process (GO:0035337)3.53147605
45creatine metabolic process (GO:0006600)3.52494899
46extracellular matrix assembly (GO:0085029)3.51777270
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.50690832
48multicellular organismal macromolecule metabolic process (GO:0044259)3.49983019
49cell differentiation involved in metanephros development (GO:0072202)3.46564086
50dermatan sulfate metabolic process (GO:0030205)3.44421073
51multicellular organismal catabolic process (GO:0044243)3.43187082
52negative regulation of protein localization to cell surface (GO:2000009)3.43051766
53negative regulation of cartilage development (GO:0061037)3.42174808
54keratan sulfate biosynthetic process (GO:0018146)3.39653356
55multicellular organismal metabolic process (GO:0044236)3.38891366
56oligodendrocyte differentiation (GO:0048709)3.35027067
57long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.32905962
58negative regulation of chondrocyte differentiation (GO:0032331)3.30170054
59mesonephros development (GO:0001823)3.29708305
60cell proliferation involved in kidney development (GO:0072111)3.26166778
61positive regulation of odontogenesis (GO:0042482)3.26089695
62organ induction (GO:0001759)3.24598101
63cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.22952121
64acyl-CoA biosynthetic process (GO:0071616)3.22652975
65thioester biosynthetic process (GO:0035384)3.22652975
66sulfur amino acid catabolic process (GO:0000098)3.19083651
67cholesterol biosynthetic process (GO:0006695)3.18110252
68middle ear morphogenesis (GO:0042474)3.16999765
69glycerophospholipid catabolic process (GO:0046475)3.14500257
70import into cell (GO:0098657)3.13914172
71bile acid metabolic process (GO:0008206)3.13221211
72complement activation, alternative pathway (GO:0006957)3.12898948
73protein localization to cell surface (GO:0034394)3.12747362
74coenzyme catabolic process (GO:0009109)3.11583139
75extracellular matrix disassembly (GO:0022617)3.10942050
76mesenchymal cell differentiation involved in kidney development (GO:0072161)3.08095877
77mesenchymal cell differentiation involved in renal system development (GO:2001012)3.08095877
78long-chain fatty acid biosynthetic process (GO:0042759)3.06797370
79glyoxylate metabolic process (GO:0046487)3.06245168
80iron coordination entity transport (GO:1901678)3.06122856
81tyrosine metabolic process (GO:0006570)3.05154107
82keratan sulfate metabolic process (GO:0042339)3.03475185
83L-amino acid import (GO:0043092)3.03164949
84mesenchyme morphogenesis (GO:0072132)3.02639215
85endocrine hormone secretion (GO:0060986)3.01762655
86aspartate family amino acid catabolic process (GO:0009068)3.00940847
87regulation of cholesterol biosynthetic process (GO:0045540)2.99229415
88dicarboxylic acid catabolic process (GO:0043649)2.98221214
89regulation of cholesterol esterification (GO:0010872)2.96703134
90regulation of protein activation cascade (GO:2000257)2.94514709
91negative regulation of catenin import into nucleus (GO:0035414)2.94446602
92regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86483531
93regulation of complement activation (GO:0030449)2.86369733
94plasma lipoprotein particle clearance (GO:0034381)2.85451299
95high-density lipoprotein particle remodeling (GO:0034375)2.83904809
96lung vasculature development (GO:0060426)2.83752867
97acyl-CoA metabolic process (GO:0006637)2.82208390
98thioester metabolic process (GO:0035383)2.82208390
99short-chain fatty acid metabolic process (GO:0046459)2.82172173
100serine family amino acid biosynthetic process (GO:0009070)2.82132499
101regulation of triglyceride catabolic process (GO:0010896)2.81818432
102virion attachment to host cell (GO:0019062)2.81434926
103adhesion of symbiont to host cell (GO:0044650)2.81434926
104regulation of cholesterol metabolic process (GO:0090181)2.80805734
105mesenchymal cell differentiation (GO:0048762)2.80573684
106vascular endothelial growth factor signaling pathway (GO:0038084)2.80509986
107opsonization (GO:0008228)2.78806282
108response to dietary excess (GO:0002021)2.78701199
109cofactor catabolic process (GO:0051187)2.78451474
110head development (GO:0060322)2.78256466
111embryonic camera-type eye development (GO:0031076)2.77589433
112sterol biosynthetic process (GO:0016126)2.77371043
113tooth mineralization (GO:0034505)2.77315820
114response to lead ion (GO:0010288)2.77084724
115aromatic amino acid family metabolic process (GO:0009072)2.76722098
116positive regulation of oligodendrocyte differentiation (GO:0048714)2.76166047
117homocysteine metabolic process (GO:0050667)2.75637597
118regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.75364202
119smooth muscle cell differentiation (GO:0051145)2.74664280
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74335796
121type B pancreatic cell proliferation (GO:0044342)2.73601177
122axon extension involved in axon guidance (GO:0048846)2.72659796
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.72659796
124regulation of female gonad development (GO:2000194)2.72385561
125ethanol oxidation (GO:0006069)2.72349103
126regulation of organ formation (GO:0003156)2.71163637
127negative regulation of BMP signaling pathway (GO:0030514)2.70318652
128venous blood vessel morphogenesis (GO:0048845)2.70133724
129protein carboxylation (GO:0018214)2.69823620
130peptidyl-glutamic acid carboxylation (GO:0017187)2.69823620
131basement membrane organization (GO:0071711)2.69774389
132amyloid precursor protein metabolic process (GO:0042982)2.69078609
133apical protein localization (GO:0045176)2.68833947
134myelination in peripheral nervous system (GO:0022011)2.68536633
135peripheral nervous system axon ensheathment (GO:0032292)2.68536633
136non-canonical Wnt signaling pathway (GO:0035567)2.68535810
137reverse cholesterol transport (GO:0043691)2.68035008
138response to mercury ion (GO:0046689)2.67303016
139outflow tract septum morphogenesis (GO:0003148)2.67256292
140negative regulation of protein activation cascade (GO:2000258)2.67132107
141fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65904081
142extracellular matrix organization (GO:0030198)2.65493391
143vasculature development (GO:0001944)2.65212041
144extracellular structure organization (GO:0043062)2.64590491
145negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.64437122
146lymph vessel development (GO:0001945)2.63804930
147cellular ketone body metabolic process (GO:0046950)2.62931410
148response to lipoprotein particle (GO:0055094)2.62574047
149alpha-amino acid catabolic process (GO:1901606)2.62422836
150amyloid precursor protein catabolic process (GO:0042987)2.58906353
151cholesterol efflux (GO:0033344)2.58763761
152establishment of mitochondrion localization (GO:0051654)2.58654066
153cellular amino acid catabolic process (GO:0009063)2.58522961
154positive regulation of triglyceride lipase activity (GO:0061365)2.57987441
155positive regulation of lipoprotein lipase activity (GO:0051006)2.57987441
156acetyl-CoA metabolic process (GO:0006084)2.57863450
157asymmetric protein localization (GO:0008105)2.57069758
158endodermal cell differentiation (GO:0035987)2.56969359
159negative regulation of neurotransmitter transport (GO:0051589)2.56539375
160blood vessel maturation (GO:0001955)2.56384646
161positive regulation of cellular amine metabolic process (GO:0033240)2.55609652
162peptide cross-linking (GO:0018149)2.54895818
163glycine transport (GO:0015816)2.54062319
164negative regulation of complement activation (GO:0045916)2.54010987
165low-density lipoprotein particle remodeling (GO:0034374)2.53459484
166planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53385965
167mesenchymal cell proliferation (GO:0010463)2.52720896
168sulfur compound catabolic process (GO:0044273)2.52365422
169fibroblast migration (GO:0010761)2.52101735
170cellular response to cholesterol (GO:0071397)2.51251054
171endocardial cushion morphogenesis (GO:0003203)2.50783260
172negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.49469253
173response to redox state (GO:0051775)2.49427636
174neutral lipid biosynthetic process (GO:0046460)2.48428433
175acylglycerol biosynthetic process (GO:0046463)2.48428433
176regulation of collateral sprouting (GO:0048670)2.48313611
177negative regulation of embryonic development (GO:0045992)2.48108397
178cholesterol metabolic process (GO:0008203)2.48014446
179glycosaminoglycan catabolic process (GO:0006027)2.47732426
180triglyceride biosynthetic process (GO:0019432)2.47597767
181astrocyte development (GO:0014002)2.47586835
182endocardial cushion development (GO:0003197)2.46316717
183camera-type eye morphogenesis (GO:0048593)2.45964476
184regulation of plasminogen activation (GO:0010755)2.45835175
185extracellular regulation of signal transduction (GO:1900115)2.45443650
186extracellular negative regulation of signal transduction (GO:1900116)2.45443650
187paraxial mesoderm development (GO:0048339)2.41908043
188radial glial cell differentiation (GO:0060019)2.41281939
189cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40715268
190chondroitin sulfate catabolic process (GO:0030207)2.39561956
191positive regulation of cardiac muscle cell proliferation (GO:0060045)2.38896374
192muscle tissue development (GO:0060537)2.37154730
193negative regulation of hormone biosynthetic process (GO:0032353)2.35371578
194regulation of cartilage development (GO:0061035)2.35129950
195negative regulation of hormone metabolic process (GO:0032351)2.34867050
196retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34699082
197tonic smooth muscle contraction (GO:0014820)2.34037551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.34491657
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.11108261
3LXR_22158963_ChIP-Seq_LIVER_Mouse2.79089227
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.79036368
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.38026847
6GBX2_23144817_ChIP-Seq_PC3_Human2.37010875
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32396555
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10283873
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.09916237
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07891354
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06019097
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05991664
13AR_21572438_ChIP-Seq_LNCaP_Human2.04475225
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92508867
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88378904
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.80419105
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79750401
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79283054
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.76812117
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76640575
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72116638
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72116638
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70108191
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.69771964
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68053766
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64970954
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58890408
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56409617
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55727377
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55727377
31* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55491570
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.50631842
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48894508
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47306404
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.45605499
36TAF15_26573619_Chip-Seq_HEK293_Human1.43776126
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41702811
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40225841
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38665306
40DROSHA_22980978_ChIP-Seq_HELA_Human1.38002676
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.37140466
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36239002
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36239002
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36239002
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35892899
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35459346
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32612970
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31760285
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31219011
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.31001700
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.29367817
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29106713
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.27158478
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24214208
55HTT_18923047_ChIP-ChIP_STHdh_Human1.23353120
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21972940
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.21298477
58EZH2_22144423_ChIP-Seq_EOC_Human1.20380412
59CLOCK_20551151_ChIP-Seq_293T_Human1.19739397
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17751636
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15625305
62SA1_22415368_ChIP-Seq_MEFs_Mouse1.14534017
63BRD4_25478319_ChIP-Seq_HGPS_Human1.13907621
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13474252
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12958130
66BCAT_22108803_ChIP-Seq_LS180_Human1.12368685
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.11639052
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.09427676
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08944000
70SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08279491
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07828813
72ER_23166858_ChIP-Seq_MCF-7_Human1.07496861
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.07412011
74TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06251429
75* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05950793
76TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05772295
77* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05732234
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04699419
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04102799
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.04090995
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03662016
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03485441
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02697573
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02270691
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02191023
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00175484
87* SMAD3_21741376_ChIP-Seq_EPCs_Human0.98307869
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.97899853
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97598737
90RING1B_27294783_Chip-Seq_ESCs_Mouse0.97321639
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96634275
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95493235
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95262655
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94733578
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94729827
96P300_19829295_ChIP-Seq_ESCs_Human0.94420589
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94210732
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94178991
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93583199
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93389203
101SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93379805
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92723887
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92648280
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91880671
105EZH2_27294783_Chip-Seq_NPCs_Mouse0.91695582
106* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91505271
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90906994
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90829006
109* EOMES_21245162_ChIP-Seq_HESCs_Human0.90827522
110* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90753276
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.90459697
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90386606
113SMAD4_21799915_ChIP-Seq_A2780_Human0.90306876
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.90234115
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.90234115
116TP53_18474530_ChIP-ChIP_U2OS_Human0.90055141
117* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88729844
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.88522466
119CBX2_27304074_Chip-Seq_ESCs_Mouse0.88354202
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.88228471
121AHR_22903824_ChIP-Seq_MCF-7_Human0.87569114
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.86710637
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.86534644
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86475329
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84534127
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84395593
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83353191
128POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82831187
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81708239
130STAT3_23295773_ChIP-Seq_U87_Human0.80287593
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79123459
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78041188
133SOX2_19829295_ChIP-Seq_ESCs_Human0.77854972
134NANOG_19829295_ChIP-Seq_ESCs_Human0.77854972
135KDM2B_26808549_Chip-Seq_REH_Human0.76732432
136TP53_16413492_ChIP-PET_HCT116_Human0.76364485
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.76236561
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.75814092
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75542318
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75454426
141CJUN_26792858_Chip-Seq_BT549_Human0.74338575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.21184189
2MP0000920_abnormal_myelination3.83153612
3MP0005360_urolithiasis3.72472776
4MP0003950_abnormal_plasma_membrane3.29787034
5MP0003806_abnormal_nucleotide_metabolis3.23438771
6MP0005257_abnormal_intraocular_pressure3.19019362
7MP0003690_abnormal_glial_cell3.16854445
8MP0009840_abnormal_foam_cell3.16767729
9MP0008438_abnormal_cutaneous_collagen3.15343768
10MP0005365_abnormal_bile_salt3.09828157
11MP0010030_abnormal_orbit_morphology2.93841710
12MP0005085_abnormal_gallbladder_physiolo2.82694574
13MP0003279_aneurysm2.79675072
14MP0003329_amyloid_beta_deposits2.52107619
15MP0008875_abnormal_xenobiotic_pharmacok2.42458380
16MP0005171_absent_coat_pigmentation2.37501915
17MP0001542_abnormal_bone_strength2.28945510
18MP0003878_abnormal_ear_physiology2.15109728
19MP0005377_hearing/vestibular/ear_phenot2.15109728
20MP0003705_abnormal_hypodermis_morpholog2.01604706
21MP0003011_delayed_dark_adaptation1.97784042
22MP0000566_synostosis1.95895469
23MP0003195_calcinosis1.95566254
24MP0005332_abnormal_amino_acid1.91126002
25MP0002102_abnormal_ear_morphology1.88680090
26MP0004885_abnormal_endolymph1.84401055
27MP0004043_abnormal_pH_regulation1.83875836
28MP0010329_abnormal_lipoprotein_level1.80998152
29MP0006054_spinal_hemorrhage1.80217140
30MP0005503_abnormal_tendon_morphology1.80170977
31MP0001661_extended_life_span1.76354645
32MP0000751_myopathy1.70941654
33MP0003634_abnormal_glial_cell1.68818036
34MP0000604_amyloidosis1.65674964
35MP0003136_yellow_coat_color1.62825447
36MP0009250_abnormal_appendicular_skeleto1.60507955
37MP0003880_abnormal_central_pattern1.58678375
38MP0002118_abnormal_lipid_homeostasis1.58430650
39MP0000767_abnormal_smooth_muscle1.52068399
40MP0003252_abnormal_bile_duct1.49998077
41MP0004142_abnormal_muscle_tone1.49436976
42MP0005275_abnormal_skin_tensile1.48880547
43MP0004381_abnormal_hair_follicle1.48807805
44MP0001879_abnormal_lymphatic_vessel1.45794020
45MP0004270_analgesia1.44527688
46MP0001486_abnormal_startle_reflex1.41756942
47MP0002060_abnormal_skin_morphology1.35263775
48MP0002933_joint_inflammation1.35247669
49MP0005390_skeleton_phenotype1.35030192
50MP0001529_abnormal_vocalization1.32808715
51MP0003632_abnormal_nervous_system1.30236629
52MP0001666_abnormal_nutrient_absorption1.28764529
53MP0002272_abnormal_nervous_system1.27881408
54MP0000049_abnormal_middle_ear1.26910156
55MP0002295_abnormal_pulmonary_circulatio1.24434913
56MP0003191_abnormal_cellular_cholesterol1.24227037
57MP0000013_abnormal_adipose_tissue1.21303232
58MP0003942_abnormal_urinary_system1.20989786
59MP0003633_abnormal_nervous_system1.17756830
60MP0003631_nervous_system_phenotype1.17035486
61MP0001905_abnormal_dopamine_level1.16638685
62MP0000163_abnormal_cartilage_morphology1.16333516
63MP0000383_abnormal_hair_follicle1.13200563
64MP0003385_abnormal_body_wall1.12671112
65MP0001346_abnormal_lacrimal_gland1.11288568
66MP0010678_abnormal_skin_adnexa1.10104815
67MP0005584_abnormal_enzyme/coenzyme_acti1.09287970
68MP0000534_abnormal_ureter_morphology1.07012458
69MP0000778_abnormal_nervous_system1.06079265
70MP0002229_neurodegeneration1.05523552
71MP0004742_abnormal_vestibular_system1.04787447
72MP0004019_abnormal_vitamin_homeostasis1.04336320
73MP0002932_abnormal_joint_morphology1.03923296
74MP0000462_abnormal_digestive_system1.03896598
75MP0004134_abnormal_chest_morphology1.03533771
76MP0002108_abnormal_muscle_morphology1.02637103
77MP0001243_abnormal_dermal_layer1.02284057
78MP0000647_abnormal_sebaceous_gland1.02196564
79MP0002896_abnormal_bone_mineralization1.01390817
80MP0002064_seizures1.00800562
81MP0003283_abnormal_digestive_organ1.00099280
82MP0000579_abnormal_nail_morphology0.99996823
83MP0000639_abnormal_adrenal_gland0.99994259
84MP0005369_muscle_phenotype0.99443866
85MP0005083_abnormal_biliary_tract0.99346588
86MP0002115_abnormal_skeleton_extremities0.99260994
87MP0001177_atelectasis0.98555458
88MP0005410_abnormal_fertilization0.97735433
89MP0005023_abnormal_wound_healing0.96072161
90MP0000733_abnormal_muscle_development0.95251766
91MP0008260_abnormal_autophagy0.93872179
92MP0003115_abnormal_respiratory_system0.91127456
93MP0005058_abnormal_lysosome_morphology0.91086869
94MP0003186_abnormal_redox_activity0.91037404
95MP0004272_abnormal_basement_membrane0.90023148
96MP0009780_abnormal_chondrocyte_physiolo0.89432419
97MP0008569_lethality_at_weaning0.88826170
98MP0002127_abnormal_cardiovascular_syste0.88724855
99MP0000428_abnormal_craniofacial_morphol0.86608397
100MP0000003_abnormal_adipose_tissue0.86582118
101MP0002233_abnormal_nose_morphology0.86140970
102MP0005451_abnormal_body_composition0.85721358
103MP0005551_abnormal_eye_electrophysiolog0.85630813
104MP0003941_abnormal_skin_development0.84754031
105MP0001958_emphysema0.83809925
106MP0005197_abnormal_uvea_morphology0.82085862
107MP0005646_abnormal_pituitary_gland0.80940960
108MP0000230_abnormal_systemic_arterial0.80465071
109MP0003075_altered_response_to0.79685753
110MP0003567_abnormal_fetal_cardiomyocyte0.78349309
111MP0001502_abnormal_circadian_rhythm0.77555964
112MP0001485_abnormal_pinna_reflex0.77268437
113MP0002128_abnormal_blood_circulation0.76659744
114MP0002113_abnormal_skeleton_development0.76514347
115MP0002116_abnormal_craniofacial_bone0.76258238
116MP0003656_abnormal_erythrocyte_physiolo0.76015955
117MP0009697_abnormal_copulation0.75319147
118MP0002133_abnormal_respiratory_system0.75016797
119MP0005388_respiratory_system_phenotype0.75016797
120MP0005375_adipose_tissue_phenotype0.73296537
121MP0000609_abnormal_liver_physiology0.72975544
122MP0004084_abnormal_cardiac_muscle0.72888034
123MP0009384_cardiac_valve_regurgitation0.72220723
124MP0005647_abnormal_sex_gland0.71519647
125MP0005409_darkened_coat_color0.71478457
126MP0000747_muscle_weakness0.71181535
127MP0005670_abnormal_white_adipose0.71106416
128MP0002109_abnormal_limb_morphology0.71075093
129MP0000762_abnormal_tongue_morphology0.70968795
130MP0001614_abnormal_blood_vessel0.70118978
131MP0002249_abnormal_larynx_morphology0.70081412
132MP0000955_abnormal_spinal_cord0.69944978
133MP0001299_abnormal_eye_distance/0.69913639
134MP0001756_abnormal_urination0.69743479
135MP0002090_abnormal_vision0.69015331
136MP0002282_abnormal_trachea_morphology0.68442814
137MP0003879_abnormal_hair_cell0.68075006
138MP0005645_abnormal_hypothalamus_physiol0.67651982
139MP0000749_muscle_degeneration0.67087698
140MP0008775_abnormal_heart_ventricle0.66413754
141MP0005508_abnormal_skeleton_morphology0.66057468
142MP0005595_abnormal_vascular_smooth0.65979207
143MP0008789_abnormal_olfactory_epithelium0.65966529
144MP0005193_abnormal_anterior_eye0.65342288
145MP0000759_abnormal_skeletal_muscle0.65245376
146MP0005666_abnormal_adipose_tissue0.65128142
147MP0003755_abnormal_palate_morphology0.64782338
148MP0000613_abnormal_salivary_gland0.63904160
149MP0004147_increased_porphyrin_level0.63223216
150MP0005423_abnormal_somatic_nervous0.62614237
151MP0010368_abnormal_lymphatic_system0.62304378
152MP0005408_hypopigmentation0.62223561
153MP0002066_abnormal_motor_capabilities/c0.62101214
154MP0000467_abnormal_esophagus_morphology0.62042385
155MP0003935_abnormal_craniofacial_develop0.61799475
156MP0003868_abnormal_feces_composition0.61001549
157MP0005620_abnormal_muscle_contractility0.60999283
158MP0005195_abnormal_posterior_eye0.60843906
159MP0006138_congestive_heart_failure0.60573256
160MP0003091_abnormal_cell_migration0.60534664
161MP0003119_abnormal_digestive_system0.57176188
162MP0002114_abnormal_axial_skeleton0.56868460
163MP0001175_abnormal_lung_morphology0.56657516
164MP0001544_abnormal_cardiovascular_syste0.56295399
165MP0005385_cardiovascular_system_phenoty0.56295399
166MP0003938_abnormal_ear_development0.55451138
167MP0005164_abnormal_response_to0.54605077
168MP0005248_abnormal_Harderian_gland0.54131893
169MP0000026_abnormal_inner_ear0.53275769
170MP0000432_abnormal_head_morphology0.52847728
171MP0003718_maternal_effect0.52214920
172MP0010386_abnormal_urinary_bladder0.51462634
173MP0002135_abnormal_kidney_morphology0.50884362
174MP0005395_other_phenotype0.49168099

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.42779406
2Neurofibrillary tangles (HP:0002185)6.09065358
3Aortic dissection (HP:0002647)5.81805141
4Aortic aneurysm (HP:0004942)5.31052714
5Soft skin (HP:0000977)5.13332103
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.88223873
7Vascular tortuosity (HP:0004948)4.85405509
8Bladder diverticulum (HP:0000015)4.66686537
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.63310771
10Degeneration of the lateral corticospinal tracts (HP:0002314)4.63310771
11Cerebral inclusion bodies (HP:0100314)4.44853519
12Intrahepatic cholestasis (HP:0001406)4.38132728
13Arterial tortuosity (HP:0005116)4.05960315
14Xanthomatosis (HP:0000991)3.80832235
15Hyperlipoproteinemia (HP:0010980)3.68539543
16Ankle contracture (HP:0006466)3.65588570
17Peritonitis (HP:0002586)3.61115303
18Shallow orbits (HP:0000586)3.56719272
19Dilatation of the ascending aorta (HP:0005111)3.54552009
20Abnormality of the corticospinal tract (HP:0002492)3.53051043
21Deep venous thrombosis (HP:0002625)3.49015920
22Fragile skin (HP:0001030)3.47337215
23Atrophic scars (HP:0001075)3.45762143
24Type 1 muscle fiber predominance (HP:0003803)3.41572887
25Striae distensae (HP:0001065)3.39633692
26Glomerulonephritis (HP:0000099)3.38239714
27Cerebral hypomyelination (HP:0006808)3.31664145
28Parakeratosis (HP:0001036)3.30884548
29Wrist flexion contracture (HP:0001239)3.24769558
30Keratoconus (HP:0000563)3.20830982
31Increased corneal curvature (HP:0100692)3.20830982
32Complement deficiency (HP:0004431)3.15063581
33Genu recurvatum (HP:0002816)3.12359996
34Prolonged partial thromboplastin time (HP:0003645)3.12175913
35Hyperextensible skin (HP:0000974)3.08994690
36Abnormal auditory evoked potentials (HP:0006958)3.04618396
37Onion bulb formation (HP:0003383)2.99511973
38Mitral valve prolapse (HP:0001634)2.99329908
39Distal arthrogryposis (HP:0005684)2.99142059
40Round ear (HP:0100830)2.97819345
41Nephritis (HP:0000123)2.96439514
42Peripheral hypomyelination (HP:0007182)2.96431297
43Cervical subluxation (HP:0003308)2.94826699
44Blue sclerae (HP:0000592)2.94618130
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.94285519
46Wormian bones (HP:0002645)2.92689410
47Alacrima (HP:0000522)2.92530621
48Amyloidosis (HP:0011034)2.85779088
49Broad metatarsal (HP:0001783)2.85242533
50Abnormality of methionine metabolism (HP:0010901)2.82613396
51Abnormality of glycine metabolism (HP:0010895)2.80376432
52Abnormality of serine family amino acid metabolism (HP:0010894)2.80376432
53Axonal loss (HP:0003447)2.80091031
54Pulmonary artery stenosis (HP:0004415)2.77723207
55Bowel diverticulosis (HP:0005222)2.77113590
56Aplasia involving bones of the extremities (HP:0009825)2.77009421
57Aplasia involving bones of the upper limbs (HP:0009823)2.77009421
58Aplasia of the phalanges of the hand (HP:0009802)2.77009421
59Follicular hyperkeratosis (HP:0007502)2.75583932
60Supranuclear gaze palsy (HP:0000605)2.75464534
61Premature skin wrinkling (HP:0100678)2.74308214
62Vertebral compression fractures (HP:0002953)2.70199346
63Coronal craniosynostosis (HP:0004440)2.67482270
64Neonatal short-limb short stature (HP:0008921)2.66758526
65Systemic lupus erythematosus (HP:0002725)2.66314195
66Abnormality of dentin (HP:0010299)2.59912618
67Intention tremor (HP:0002080)2.58371519
68Wide anterior fontanel (HP:0000260)2.57744536
69Epidermoid cyst (HP:0200040)2.54638345
70Biconcave vertebral bodies (HP:0004586)2.54090190
71Osteoarthritis (HP:0002758)2.53731525
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51871257
73Joint laxity (HP:0001388)2.51346939
74Cerebral aneurysm (HP:0004944)2.50776422
75Hypophosphatemic rickets (HP:0004912)2.50688186
76Turricephaly (HP:0000262)2.47450317
77Limited hip movement (HP:0008800)2.46770187
78Vascular calcification (HP:0004934)2.46366435
79Scanning speech (HP:0002168)2.44663456
80Methylmalonic acidemia (HP:0002912)2.44068938
81Abnormality of the anterior chamber (HP:0000593)2.43788376
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.41969661
83Aplasia of the musculature (HP:0100854)2.41869239
84Aortic valve stenosis (HP:0001650)2.41238959
85Cardiovascular calcification (HP:0011915)2.41065250
86Overgrowth (HP:0001548)2.41014675
87Spondylolisthesis (HP:0003302)2.40562109
88Megalencephaly (HP:0001355)2.39485752
89Spastic paraparesis (HP:0002313)2.39380942
90Spinal rigidity (HP:0003306)2.39048498
91Osteolytic defects of the phalanges of the hand (HP:0009771)2.38891747
92Osteolytic defects of the hand bones (HP:0009699)2.38891747
93Joint stiffness (HP:0001387)2.38358698
94Humeroradial synostosis (HP:0003041)2.37763992
95Synostosis involving the elbow (HP:0003938)2.37763992
96Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37251973
97Cerebral hemorrhage (HP:0001342)2.36140574
98Calcaneovalgus deformity (HP:0001848)2.35883595
99Hip contracture (HP:0003273)2.33758296
100Hypobetalipoproteinemia (HP:0003563)2.31916603
101Absent phalangeal crease (HP:0006109)2.30727518
102Deformed tarsal bones (HP:0008119)2.29486800
103Hypoalphalipoproteinemia (HP:0003233)2.29447828
104Abnormality of the phalanges of the 2nd finger (HP:0009541)2.28882279
105Ectopia lentis (HP:0001083)2.28393500
106Aneurysm (HP:0002617)2.28103180
107Termporal pattern (HP:0011008)2.27393743
108Insidious onset (HP:0003587)2.27393743
109Abnormal delivery (HP:0001787)2.27014836
110Narrow nasal bridge (HP:0000446)2.26549543
111Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23860112
112Hyperammonemia (HP:0001987)2.22468282
113Ketosis (HP:0001946)2.22170029
114Segmental peripheral demyelination/remyelination (HP:0003481)2.21291041
115Leukodystrophy (HP:0002415)2.20899672
116Decreased lacrimation (HP:0000633)2.18792229
117Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.18334530
118Clumsiness (HP:0002312)2.15090405
119CNS hypomyelination (HP:0003429)2.14851794
120Abnormality of the middle phalanges of the toes (HP:0010183)2.14661113
121Hypolipoproteinemia (HP:0010981)2.14585415
122Venous insufficiency (HP:0005293)2.14479312
123Spastic gait (HP:0002064)2.13949850
124Fat malabsorption (HP:0002630)2.12074118
125Premature rupture of membranes (HP:0001788)2.12027485
126Sensory axonal neuropathy (HP:0003390)2.11910899
127Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.11857140
128Abnormality of fatty-acid metabolism (HP:0004359)2.11118358
129Infantile muscular hypotonia (HP:0008947)2.10835036
130Peripheral demyelination (HP:0011096)2.07867438
131Corneal dystrophy (HP:0001131)2.06889336
132Mitral stenosis (HP:0001718)2.06031412
133Anterior segment dysgenesis (HP:0007700)2.05477155
134Paraparesis (HP:0002385)2.05285501
135Ulnar deviation of the wrist (HP:0003049)2.05227440
136Thickened helices (HP:0000391)2.04418959
137Slender build (HP:0001533)2.03479609
138Increased variability in muscle fiber diameter (HP:0003557)2.02012788
139Prolonged neonatal jaundice (HP:0006579)2.00791148
140Aortic regurgitation (HP:0001659)2.00401027
141Pancreatic islet-cell hyperplasia (HP:0004510)2.00285542
142Hyperglycinemia (HP:0002154)1.98719916
143Anteriorly placed anus (HP:0001545)1.96910122
144Emphysema (HP:0002097)1.96606060
145Torticollis (HP:0000473)1.95431017
146Hyperglycinuria (HP:0003108)1.95163325
147Partial duplication of the phalanx of hand (HP:0009999)1.94626515
148White forelock (HP:0002211)1.94594635
149Mild short stature (HP:0003502)1.93089087
150Venous abnormality (HP:0002624)1.92981739
151Steatorrhea (HP:0002570)1.92768650
152Thin bony cortex (HP:0002753)1.91851186
153Abnormality of complement system (HP:0005339)1.91464061
154Hypoglycemic coma (HP:0001325)1.90931876
155Hypoplasia of the iris (HP:0007676)1.90779597
156Camptodactyly of toe (HP:0001836)1.90756305
157Joint hemorrhage (HP:0005261)1.90435648
158Hepatosplenomegaly (HP:0001433)1.89334180
159Patchy hypopigmentation of hair (HP:0011365)1.88078420
160Recurrent corneal erosions (HP:0000495)1.88067988
161Muscle fiber splitting (HP:0003555)1.86932768
162Delayed CNS myelination (HP:0002188)1.86604454
163Abnormal gallbladder physiology (HP:0012438)1.86274020
164Cholecystitis (HP:0001082)1.86274020
165Abnormal finger flexion creases (HP:0006143)1.86061091
166Spastic tetraparesis (HP:0001285)1.85810168
167Broad ribs (HP:0000885)1.85327506
168Myokymia (HP:0002411)1.85205200
169Conjugated hyperbilirubinemia (HP:0002908)1.85131471
170Confusion (HP:0001289)1.85118768
171Breech presentation (HP:0001623)1.84541835
172Abnormal gallbladder morphology (HP:0012437)1.84480202
173Dysmetria (HP:0001310)1.83493444
174Congenital ichthyosiform erythroderma (HP:0007431)1.81292595
175Choreoathetosis (HP:0001266)1.81287619
176Deviation of the hallux (HP:0010051)1.76560681
177Hallux valgus (HP:0001822)1.75844165
178Delayed cranial suture closure (HP:0000270)1.75574759
179Ovoid vertebral bodies (HP:0003300)1.74465879
180Flat cornea (HP:0007720)1.72697564
181Inguinal hernia (HP:0000023)1.71385551
182Mildly elevated creatine phosphokinase (HP:0008180)1.71270861
183Thin skin (HP:0000963)1.68797237
184Broad toe (HP:0001837)1.67753268
185Gingival overgrowth (HP:0000212)1.66921637
186Preaxial foot polydactyly (HP:0001841)1.66818075
187Abnormality of the acetabulum (HP:0003170)1.64654453
188Aplasia/Hypoplasia of the hallux (HP:0008362)1.63970162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.16763877
2MYLK3.97689100
3FGFR23.87203281
4TGFBR23.64671455
5OXSR13.52578461
6PDGFRA3.19446929
7LATS13.17352355
8PKN13.06561849
9EPHB12.89470293
10BCKDK2.38887840
11MET2.32529888
12RIPK12.28307938
13INSRR2.08480403
14EPHB22.06006811
15MAPKAPK52.01627684
16KIT1.95631799
17SIK11.94893570
18NEK91.93527692
19PBK1.91953265
20GRK51.91779133
21MOS1.90614352
22BCR1.86871167
23WNK41.86169737
24LIMK11.84815319
25CSNK1A1L1.77258826
26STK38L1.73849974
27SGK2231.70927045
28SGK4941.70927045
29CSNK1G31.70205182
30MAPKAPK31.69019385
31TGFBR11.67576886
32NEK61.63686459
33CAMK2B1.57023091
34PHKG21.55534809
35PHKG11.55534809
36NTRK11.53321748
37PAK21.52800622
38STK31.50227403
39NLK1.49604223
40CSNK1G11.49567140
41PRPF4B1.48765704
42WNK11.47477863
43DMPK1.41800574
44GRK11.41771117
45ROCK21.41681732
46ADRBK11.38111682
47CASK1.37670795
48LATS21.34925389
49CSNK1G21.33645743
50PIK3CG1.32631417
51UHMK11.30409589
52AKT31.28962415
53CAMK2D1.27903139
54CAMK2G1.27672473
55PRKD31.25130443
56PAK61.23680863
57FRK1.23213203
58EPHA41.20790320
59ERN11.20627742
60ADRBK21.19842887
61MST41.18409490
62GRK71.15525527
63PRKCH1.10263730
64PINK11.09835728
65CDC42BPA1.08093969
66STK381.07861660
67MAP3K61.05890137
68PDGFRB1.05711627
69PRKD11.02349511
70CAMK1G1.00812977
71EPHA31.00801978
72FGR0.99664065
73BMPR1B0.99342873
74ERBB40.98604606
75DYRK20.97378186
76CDK190.96666437
77NTRK20.96237787
78CAMK1D0.94434485
79PTK20.94129650
80MAP2K20.92732299
81LMTK20.90578816
82FER0.90282620
83TESK20.90274786
84NME10.89898351
85MAP2K10.89818079
86ACVR1B0.89703551
87PDK20.89696808
88STK240.89515023
89ABL20.89003316
90CAMK2A0.88663156
91CLK10.88276130
92PRKCQ0.86922415
93TRIB30.86005246
94GSK3A0.85492270
95MARK20.84893521
96EEF2K0.82453542
97ARAF0.81306875
98PRKCE0.75883833
99ROCK10.72311994
100DDR20.72135634
101TRPM70.71650624
102MAP3K130.70776756
103PIK3CA0.70330824
104MAP3K70.67826350
105MUSK0.67213565
106TIE10.66675335
107IRAK20.65699910
108PAK30.65597026
109MAPK120.64832419
110TESK10.64741460
111PRKD20.64202425
112CDK50.63702660
113MAPK150.63668951
114PDPK10.61787092
115PRKG10.61604359
116RPS6KA20.60501205
117ERBB30.60117084
118MARK10.59857587
119RET0.58179258
120MAPK70.57770039
121FGFR40.56436514
122MAPK40.55623643
123MST1R0.54624394
124TYK20.53381199
125ICK0.52483727
126BMX0.52410770
127PRKACB0.50388496
128PTK2B0.50078494
129CAMK10.49164995
130FGFR30.48591439
131CSNK1A10.48583217
132NTRK30.48395484
133FLT30.48057085
134FYN0.48055550
135CSNK1D0.47807062
136TNIK0.47599596
137TYRO30.47010351
138FGFR10.46334421
139RPS6KA60.46260317
140RPS6KC10.45881328
141RPS6KL10.45881328
142DAPK30.45819012
143MAPK10.45619660
144DAPK20.45216751
145PRKAA20.44596477
146CDK140.43623443
147MTOR0.42558647
148PRKACA0.41796316
149CDK150.41273630
150MELK0.40964212
151TTN0.40033773
152ILK0.39264416
153PRKCZ0.38374425
154PNCK0.38035913
155MAPK130.34927070
156CDK180.34867220
157CSK0.33817495
158PRKACG0.33285876
159INSR0.32086628
160PTK60.29628478
161OBSCN0.28971524
162CDK11A0.28908970

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.16010492
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.56307959
3Fatty acid elongation_Homo sapiens_hsa000623.40722295
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.14055099
5Steroid biosynthesis_Homo sapiens_hsa001002.64910417
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.63385486
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41293902
8Vitamin B6 metabolism_Homo sapiens_hsa007502.40106522
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29304912
10Focal adhesion_Homo sapiens_hsa045102.28126066
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.26194049
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25558206
13Histidine metabolism_Homo sapiens_hsa003402.22771176
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20547801
15Sulfur metabolism_Homo sapiens_hsa009202.19530720
16Propanoate metabolism_Homo sapiens_hsa006402.15926714
17Fatty acid metabolism_Homo sapiens_hsa012122.01491702
18Butanoate metabolism_Homo sapiens_hsa006501.97163668
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93737458
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87247382
21Arginine biosynthesis_Homo sapiens_hsa002201.85860167
22Amoebiasis_Homo sapiens_hsa051461.83214964
23Fatty acid degradation_Homo sapiens_hsa000711.82888854
24Complement and coagulation cascades_Homo sapiens_hsa046101.79398247
25Dilated cardiomyopathy_Homo sapiens_hsa054141.78433893
26PPAR signaling pathway_Homo sapiens_hsa033201.74362890
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73692407
28Peroxisome_Homo sapiens_hsa041461.71204372
29Basal cell carcinoma_Homo sapiens_hsa052171.70223616
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68067325
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.63391851
32Tryptophan metabolism_Homo sapiens_hsa003801.62217668
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60537282
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58697228
35Hedgehog signaling pathway_Homo sapiens_hsa043401.55110413
36Chemical carcinogenesis_Homo sapiens_hsa052041.53254721
37TGF-beta signaling pathway_Homo sapiens_hsa043501.49806342
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.49726645
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43654277
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43630580
41Circadian rhythm_Homo sapiens_hsa047101.40816943
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37948631
43Ether lipid metabolism_Homo sapiens_hsa005651.37662347
44Retinol metabolism_Homo sapiens_hsa008301.36453651
45Renin secretion_Homo sapiens_hsa049241.33078605
46Arginine and proline metabolism_Homo sapiens_hsa003301.32347833
47beta-Alanine metabolism_Homo sapiens_hsa004101.32123033
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30596542
49Tyrosine metabolism_Homo sapiens_hsa003501.25822602
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24581625
51Fatty acid biosynthesis_Homo sapiens_hsa000611.22733098
52Vitamin digestion and absorption_Homo sapiens_hsa049771.20245606
53Folate biosynthesis_Homo sapiens_hsa007901.18392011
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16633105
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14889249
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11328603
57Linoleic acid metabolism_Homo sapiens_hsa005911.09961589
58Proteoglycans in cancer_Homo sapiens_hsa052051.09776365
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09619602
60Bile secretion_Homo sapiens_hsa049761.06684347
61Dorso-ventral axis formation_Homo sapiens_hsa043201.05351821
62Pyruvate metabolism_Homo sapiens_hsa006201.04373215
63Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04226516
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03250203
65Staphylococcus aureus infection_Homo sapiens_hsa051500.99745164
66Melanoma_Homo sapiens_hsa052180.98488599
67Renin-angiotensin system_Homo sapiens_hsa046140.98287041
68Pathways in cancer_Homo sapiens_hsa052000.95589733
69Phenylalanine metabolism_Homo sapiens_hsa003600.94443625
70Wnt signaling pathway_Homo sapiens_hsa043100.92431961
71Melanogenesis_Homo sapiens_hsa049160.91890413
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89249360
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87907331
74Small cell lung cancer_Homo sapiens_hsa052220.87867617
75Glutathione metabolism_Homo sapiens_hsa004800.87452069
76Pertussis_Homo sapiens_hsa051330.87219137
77ABC transporters_Homo sapiens_hsa020100.84723952
78Hippo signaling pathway_Homo sapiens_hsa043900.84356709
79Caffeine metabolism_Homo sapiens_hsa002320.82347233
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78896917
81Gap junction_Homo sapiens_hsa045400.78865643
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76043917
83Fat digestion and absorption_Homo sapiens_hsa049750.75926061
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75287789
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75141202
86Glycerolipid metabolism_Homo sapiens_hsa005610.75092673
87Calcium signaling pathway_Homo sapiens_hsa040200.70580304
88Ras signaling pathway_Homo sapiens_hsa040140.68112626
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.67583975
90Arachidonic acid metabolism_Homo sapiens_hsa005900.66628448
91Biosynthesis of amino acids_Homo sapiens_hsa012300.64876926
92Starch and sucrose metabolism_Homo sapiens_hsa005000.64083128
93Sulfur relay system_Homo sapiens_hsa041220.63880068
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.61122223
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60767670
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56926679
97Carbon metabolism_Homo sapiens_hsa012000.56144004
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.55269557
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55084973
100Phototransduction_Homo sapiens_hsa047440.52500446
101Oxytocin signaling pathway_Homo sapiens_hsa049210.52097726
102Axon guidance_Homo sapiens_hsa043600.50876177
103Rap1 signaling pathway_Homo sapiens_hsa040150.50690277
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50274112
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50262655
106Serotonergic synapse_Homo sapiens_hsa047260.49219521
107Metabolic pathways_Homo sapiens_hsa011000.48811787
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47720087
109Sphingolipid metabolism_Homo sapiens_hsa006000.47465412
110Prion diseases_Homo sapiens_hsa050200.46998103
111GABAergic synapse_Homo sapiens_hsa047270.46988708
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46785193
113cAMP signaling pathway_Homo sapiens_hsa040240.45671976
114Ovarian steroidogenesis_Homo sapiens_hsa049130.43520920
115Taste transduction_Homo sapiens_hsa047420.42152260
116Protein export_Homo sapiens_hsa030600.39163229
117Long-term depression_Homo sapiens_hsa047300.39069954
118Cocaine addiction_Homo sapiens_hsa050300.37129484
119Lysosome_Homo sapiens_hsa041420.36636745
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36565197
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.34057981
122Circadian entrainment_Homo sapiens_hsa047130.33150743
123Lysine degradation_Homo sapiens_hsa003100.32993048
124Glutamatergic synapse_Homo sapiens_hsa047240.32919513
125Adherens junction_Homo sapiens_hsa045200.30718458
126Oxidative phosphorylation_Homo sapiens_hsa001900.30586255
127Mineral absorption_Homo sapiens_hsa049780.28019680
128ECM-receptor interaction_Homo sapiens_hsa045120.23599340
129Alzheimers disease_Homo sapiens_hsa050100.21609502
130Protein digestion and absorption_Homo sapiens_hsa049740.19102297
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18785265
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.18523888
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18272857
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.17495276
135Pentose phosphate pathway_Homo sapiens_hsa000300.17038321
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15114247
137Selenocompound metabolism_Homo sapiens_hsa004500.14817909
138Malaria_Homo sapiens_hsa051440.14782162
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14308761
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13919552
141Tight junction_Homo sapiens_hsa045300.13891375
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13843897
143Morphine addiction_Homo sapiens_hsa050320.13063629
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.13053112
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.10076873
146Parkinsons disease_Homo sapiens_hsa050120.08247243
147Thyroid hormone synthesis_Homo sapiens_hsa049180.07785974

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