OLAH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine-containing compound transmembrane transport (GO:0072531)9.83405254
2fatty-acyl-CoA biosynthetic process (GO:0046949)8.33691365
3long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)8.16431005
4acyl-CoA biosynthetic process (GO:0071616)8.14784037
5thioester biosynthetic process (GO:0035384)8.14784037
6pattern specification involved in kidney development (GO:0061004)8.05057319
7regulation of sequestering of triglyceride (GO:0010889)7.91541973
8alpha-linolenic acid metabolic process (GO:0036109)7.82929050
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)7.51557415
10linoleic acid metabolic process (GO:0043651)6.96143608
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.74797727
12lactation (GO:0007595)6.59573672
13nucleoside transmembrane transport (GO:1901642)6.58927411
14fatty acid transmembrane transport (GO:1902001)6.40414678
15carnitine shuttle (GO:0006853)6.39354928
16positive regulation of p38MAPK cascade (GO:1900745)6.32917133
17long-chain fatty-acyl-CoA metabolic process (GO:0035336)6.20088336
18fatty-acyl-CoA metabolic process (GO:0035337)5.93339326
19mammary gland epithelial cell differentiation (GO:0060644)5.88899106
20negative regulation of execution phase of apoptosis (GO:1900118)5.85370324
21biotin metabolic process (GO:0006768)5.76731678
22ectoderm development (GO:0007398)5.53207401
23response to phenylpropanoid (GO:0080184)5.43321139
24secretion by tissue (GO:0032941)5.36761826
25nucleobase catabolic process (GO:0046113)5.27760462
26acetyl-CoA metabolic process (GO:0006084)5.25609304
27N-acetylneuraminate metabolic process (GO:0006054)5.09647498
28folic acid transport (GO:0015884)5.08274305
29nucleoside transport (GO:0015858)4.92091374
30embryonic process involved in female pregnancy (GO:0060136)4.90600839
31triglyceride biosynthetic process (GO:0019432)4.82841161
32zinc ion transport (GO:0006829)4.79640749
33carnitine transmembrane transport (GO:1902603)4.77435584
34regulation of apoptotic process involved in morphogenesis (GO:1902337)4.71735418
35tooth mineralization (GO:0034505)4.69936206
36intestinal cholesterol absorption (GO:0030299)4.69210844
37behavioral response to nicotine (GO:0035095)4.68806642
38acylglycerol biosynthetic process (GO:0046463)4.68124156
39neutral lipid biosynthetic process (GO:0046460)4.68124156
40coenzyme A biosynthetic process (GO:0015937)4.57981144
41O-glycan processing (GO:0016266)4.49242937
42body fluid secretion (GO:0007589)4.46264080
43segment specification (GO:0007379)4.40523852
44carnitine transport (GO:0015879)4.40485769
45amino-acid betaine transport (GO:0015838)4.40485769
46heme transport (GO:0015886)4.29853089
47lipid storage (GO:0019915)4.29724935
48long-chain fatty acid transport (GO:0015909)4.29596363
49regulation of p38MAPK cascade (GO:1900744)4.24629887
50DNA deamination (GO:0045006)4.17180065
51fucose catabolic process (GO:0019317)4.14010819
52L-fucose metabolic process (GO:0042354)4.14010819
53L-fucose catabolic process (GO:0042355)4.14010819
54positive regulation of lipid storage (GO:0010884)4.05112149
55urate metabolic process (GO:0046415)4.03458374
56intracellular lipid transport (GO:0032365)4.02192361
57positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.95576768
58copper ion transport (GO:0006825)3.93228364
59phospholipid homeostasis (GO:0055091)3.92822717
60fatty acid transport (GO:0015908)3.83021474
61positive regulation of macrophage cytokine production (GO:0060907)3.82590543
62cholesterol catabolic process (GO:0006707)3.82030288
63sterol catabolic process (GO:0016127)3.82030288
64oligosaccharide metabolic process (GO:0009311)3.75511100
65phagocytosis, recognition (GO:0006910)3.69530090
66Golgi transport vesicle coating (GO:0048200)3.67251625
67COPI coating of Golgi vesicle (GO:0048205)3.67251625
68transcytosis (GO:0045056)3.66488430
69response to pheromone (GO:0019236)3.66383512
70sialylation (GO:0097503)3.63168482
71thioester metabolic process (GO:0035383)3.61631581
72acyl-CoA metabolic process (GO:0006637)3.61631581
73regulation of penile erection (GO:0060405)3.61387908
74positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.60181691
75regulation of triglyceride metabolic process (GO:0090207)3.57524669
76iron coordination entity transport (GO:1901678)3.54541258
77regulation of triglyceride biosynthetic process (GO:0010866)3.53698728
78regulation of vasculogenesis (GO:2001212)3.53174476
79coenzyme A metabolic process (GO:0015936)3.49672392
80regulation of endothelial cell differentiation (GO:0045601)3.49340880
81cellular ketone body metabolic process (GO:0046950)3.46609746
82positive regulation of triglyceride metabolic process (GO:0090208)3.46232823
83folic acid metabolic process (GO:0046655)3.43243692
84regulation of acrosome reaction (GO:0060046)3.41108801
85regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.38630866
86regulation of phospholipid biosynthetic process (GO:0071071)3.36571161
87low-density lipoprotein particle clearance (GO:0034383)3.36244441
88regulation of triglyceride catabolic process (GO:0010896)3.35235547
89cofactor transport (GO:0051181)3.35200818
90vitamin A metabolic process (GO:0006776)3.33496795
91growth hormone receptor signaling pathway (GO:0060396)3.33105697
92regulation of clathrin-mediated endocytosis (GO:2000369)3.32681256
93positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28736029
94ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.28013865
95nucleoside bisphosphate biosynthetic process (GO:0033866)3.28013865
96purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.28013865
97triglyceride metabolic process (GO:0006641)3.25702093
98cellular response to vitamin D (GO:0071305)3.22926266
99water-soluble vitamin biosynthetic process (GO:0042364)3.21635404
100platelet dense granule organization (GO:0060155)3.20924344
101axoneme assembly (GO:0035082)3.19511552
102angiogenesis involved in wound healing (GO:0060055)3.19203513
103regulation of macrophage cytokine production (GO:0010935)3.17593056
104tryptophan catabolic process (GO:0006569)3.15773766
105indole-containing compound catabolic process (GO:0042436)3.15773766
106indolalkylamine catabolic process (GO:0046218)3.15773766
107acylglycerol metabolic process (GO:0006639)3.15486586
108kynurenine metabolic process (GO:0070189)3.14575947
109regulation of early endosome to late endosome transport (GO:2000641)3.12718239
110positive regulation of triglyceride lipase activity (GO:0061365)3.12232103
111positive regulation of lipoprotein lipase activity (GO:0051006)3.12232103
112quaternary ammonium group transport (GO:0015697)3.11721484
113neutral lipid metabolic process (GO:0006638)3.11271208
114localization within membrane (GO:0051668)3.10352566
115valine metabolic process (GO:0006573)3.08520409
116regulation of acyl-CoA biosynthetic process (GO:0050812)3.07667155
117detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.06935877
118ketone body metabolic process (GO:1902224)3.05496677
119galactose metabolic process (GO:0006012)3.04373708
120piRNA metabolic process (GO:0034587)3.04237127
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98814023
122intestinal absorption (GO:0050892)2.94742652
123indolalkylamine metabolic process (GO:0006586)2.94097115
124tryptophan metabolic process (GO:0006568)2.90322965
125mitochondrial calcium ion transport (GO:0006851)2.90132479
126multicellular organism reproduction (GO:0032504)2.88151869
127sulfation (GO:0051923)2.82424097
128detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.79886063
129gamma-aminobutyric acid transport (GO:0015812)2.79465490
130negative regulation of mast cell activation (GO:0033004)2.77758118
131basic amino acid transport (GO:0015802)2.77702656
132negative regulation of telomere maintenance (GO:0032205)2.76627258
133kidney morphogenesis (GO:0060993)2.70878677
134negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69513310
135respiratory chain complex IV assembly (GO:0008535)2.65717699
136mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63523050
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.63523050
138NADH dehydrogenase complex assembly (GO:0010257)2.63523050
139preassembly of GPI anchor in ER membrane (GO:0016254)2.61350330
140regulation of mesoderm development (GO:2000380)2.61008993
141nonmotile primary cilium assembly (GO:0035058)2.60877766
142pantothenate metabolic process (GO:0015939)2.60726867
143detection of light stimulus involved in sensory perception (GO:0050962)2.60440946
144detection of light stimulus involved in visual perception (GO:0050908)2.60440946
145phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.55749109
146protein complex biogenesis (GO:0070271)2.54053512
147regulation of hippo signaling (GO:0035330)2.52848775
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52691501
149RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52691501
150estrogen biosynthetic process (GO:0006703)2.52040308
151indole-containing compound metabolic process (GO:0042430)2.51984622
152positive regulation of toll-like receptor signaling pathway (GO:0034123)2.51143164
153regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50876014
154DNA methylation involved in gamete generation (GO:0043046)2.50182149
155atrial cardiac muscle cell action potential (GO:0086014)2.49966867
156negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47954259
157alanine transport (GO:0032328)2.47501468
158NAD biosynthetic process (GO:0009435)2.46703058
159branched-chain amino acid catabolic process (GO:0009083)2.46438011
160epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45304184
161cysteine metabolic process (GO:0006534)2.44342745
162mitochondrial respiratory chain complex assembly (GO:0033108)2.43806020
163somite development (GO:0061053)2.43772312
164protein polyglutamylation (GO:0018095)2.42477508
165branched-chain amino acid metabolic process (GO:0009081)2.42061454
166reflex (GO:0060004)2.42044534
167cellular response to ATP (GO:0071318)2.41813723
168regulation of rhodopsin mediated signaling pathway (GO:0022400)2.39227463
169neural tube formation (GO:0001841)2.39204549
170phosphatidylinositol acyl-chain remodeling (GO:0036149)2.39092133
171cilium morphogenesis (GO:0060271)2.38493204
172primary amino compound metabolic process (GO:1901160)2.38202937
173cytidine metabolic process (GO:0046087)2.36875879
174cytidine catabolic process (GO:0006216)2.36875879
175cytidine deamination (GO:0009972)2.36875879
176pseudouridine synthesis (GO:0001522)2.36107196
177epithelial cilium movement (GO:0003351)2.36096498
178negative regulation of transcription regulatory region DNA binding (GO:2000678)2.33919862
179L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.33753875
180oligosaccharide biosynthetic process (GO:0009312)12.8160091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse8.33110969
2ESR1_21235772_ChIP-Seq_MCF-7_Human5.77051175
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.56121900
4ESR2_21235772_ChIP-Seq_MCF-7_Human4.11380124
5ZNF274_21170338_ChIP-Seq_K562_Hela3.80596011
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.59222156
7VDR_22108803_ChIP-Seq_LS180_Human3.53083663
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.49689717
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.23526379
10CLOCK_20551151_ChIP-Seq_293T_Human3.05744153
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.95586683
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81923141
13AR_21572438_ChIP-Seq_LNCaP_Human2.69334974
14GBX2_23144817_ChIP-Seq_PC3_Human2.64568365
15EZH2_22144423_ChIP-Seq_EOC_Human2.63718767
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55677980
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.47746802
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.37127915
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35969797
20IGF1R_20145208_ChIP-Seq_DFB_Human2.35580722
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34552835
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19681741
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.17471995
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.16953772
25ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.07176107
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00463671
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95949854
28ZNF263_19887448_ChIP-Seq_K562_Human1.95050936
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.91334942
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90400934
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89431377
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89008778
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.87241638
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86706794
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.84508870
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84054840
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83833566
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.82598462
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81000217
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.79589581
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77207482
42FUS_26573619_Chip-Seq_HEK293_Human1.75650769
43TP53_22573176_ChIP-Seq_HFKS_Human1.72669896
44P300_19829295_ChIP-Seq_ESCs_Human1.72434123
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.71309100
46TAF15_26573619_Chip-Seq_HEK293_Human1.70846239
47ER_23166858_ChIP-Seq_MCF-7_Human1.70676196
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68762632
49EWS_26573619_Chip-Seq_HEK293_Human1.67867572
50SOX2_20726797_ChIP-Seq_SW620_Human1.67591690
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61282684
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.58403438
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.57068631
54NANOG_19829295_ChIP-Seq_ESCs_Human1.54759473
55SOX2_19829295_ChIP-Seq_ESCs_Human1.54759473
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52956586
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50913094
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48584853
59CBP_20019798_ChIP-Seq_JUKART_Human1.48584853
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45832808
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.44844659
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43295068
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.39920237
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39920237
65IRF1_19129219_ChIP-ChIP_H3396_Human1.39630638
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.38797587
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37810425
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.37113281
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36105632
70GATA4_25053715_ChIP-Seq_YYC3_Human1.35602081
71TCF4_23295773_ChIP-Seq_U87_Human1.33505137
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33046794
73STAT3_23295773_ChIP-Seq_U87_Human1.32408157
74REST_21632747_ChIP-Seq_MESCs_Mouse1.31408185
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31066511
76KLF5_25053715_ChIP-Seq_YYC3_Human1.30939256
77BCAT_22108803_ChIP-Seq_LS180_Human1.30925447
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29298691
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28086279
80AR_20517297_ChIP-Seq_VCAP_Human1.27932038
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27626735
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.27481991
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.27239505
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.26708865
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26351777
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24730351
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.23548308
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22045145
89GATA3_24758297_ChIP-Seq_MCF-7_Human1.21473262
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21110623
91* TCF4_22108803_ChIP-Seq_LS180_Human1.21013115
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20938865
93* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20478627
94NCOR_22424771_ChIP-Seq_293T_Human1.20365215
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19937004
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19742177
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19742177
98EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19612499
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18998314
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18621748
101HOXB7_26014856_ChIP-Seq_BT474_Human1.18583393
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18408489
103SMAD4_21799915_ChIP-Seq_A2780_Human1.16884755
104RUNX2_22187159_ChIP-Seq_PCA_Human1.15664051
105TAF2_19829295_ChIP-Seq_ESCs_Human1.15463888
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14269251
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.11888509
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11392971
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.11294958
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.11294958
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11171838
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10866926
113MYC_19829295_ChIP-Seq_ESCs_Human1.10628213
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09653331
115MYC_18940864_ChIP-ChIP_HL60_Human1.09605655
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08454489
117ATF3_27146783_Chip-Seq_COLON_Human1.08189232
118* TP63_23658742_ChIP-Seq_EP156T_Human1.08007016
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07955020
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07546224
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07473369
122ERA_21632823_ChIP-Seq_H3396_Human1.06975037
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05683735
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.05296269
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05141562
126P53_22387025_ChIP-Seq_ESCs_Mouse1.04807994
127FOXA1_25552417_ChIP-Seq_VCAP_Human1.04353007
128FOXH1_21741376_ChIP-Seq_EPCs_Human1.03293607
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03064366
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03007178
131* RXR_22108803_ChIP-Seq_LS180_Human1.02363468
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.01655958
133MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00666633
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.00445491
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.00399361
136* STAT3_18555785_Chip-Seq_ESCs_Mouse1.00199186
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99905356
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.99034480
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98983698
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98772669
141RACK7_27058665_Chip-Seq_MCF-7_Human0.98230561
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97800247
143CJUN_26792858_Chip-Seq_BT549_Human0.97756238
144* SMAD3_21741376_ChIP-Seq_EPCs_Human0.96337864
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96244226
146FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95923728
147AR_25329375_ChIP-Seq_VCAP_Human0.94976846
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.93529761
149TP53_16413492_ChIP-PET_HCT116_Human0.92174129
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90845135
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89044452
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88620112
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88135375
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88113632
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87991886
156SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87897434
157CHD1_26751641_Chip-Seq_LNCaP_Human0.87202100
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86728863
159TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85811287
160SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84659052
161P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84658297
162GATA1_19941826_ChIP-Seq_K562_Human0.83979098
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83836267
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83531844
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82870796
166ERG_20517297_ChIP-Seq_VCAP_Human0.82705881
167GATA2_19941826_ChIP-Seq_K562_Human0.79855904
168NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79394520
169TP53_18474530_ChIP-ChIP_U2OS_Human0.79102010
170FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78441535
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78324812
172HTT_18923047_ChIP-ChIP_STHdh_Human0.77063553
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77032106
174HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76812150
175ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76143703
176CDX2_22108803_ChIP-Seq_LS180_Human0.75857397
177EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75116268
178GATA6_25053715_ChIP-Seq_YYC3_Human0.74167634
179CREB1_26743006_Chip-Seq_LNCaP_Human0.74150371
180WDR5_24793694_ChIP-Seq_LNCAP_Human0.73272725
181NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73175859
182P53_21459846_ChIP-Seq_SAOS-2_Human0.72806120
183NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.70779365
184CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70707836
185SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.70038567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.51742723
2MP0000627_abnormal_mammary_gland3.56698475
3MP0003136_yellow_coat_color3.56350643
4MP0005083_abnormal_biliary_tract3.46983418
5MP0003303_peritoneal_inflammation3.31028220
6MP0003718_maternal_effect3.09793049
7MP0001873_stomach_inflammation3.06238288
8MP0004019_abnormal_vitamin_homeostasis2.95496501
9MP0004147_increased_porphyrin_level2.73777509
10MP0004130_abnormal_muscle_cell2.72993103
11MP0003300_gastrointestinal_ulcer2.71468925
12MP0004043_abnormal_pH_regulation2.63743434
13MP0005645_abnormal_hypothalamus_physiol2.45875547
14MP0002254_reproductive_system_inflammat2.42228290
15MP0003195_calcinosis2.36650600
16MP0005360_urolithiasis2.30056735
17MP0003011_delayed_dark_adaptation2.22614621
18MP0005085_abnormal_gallbladder_physiolo2.20211922
19MP0005551_abnormal_eye_electrophysiolog2.13072468
20MP0001881_abnormal_mammary_gland13.0150192
21MP0002796_impaired_skin_barrier1.99277879
22MP0008877_abnormal_DNA_methylation1.99214371
23MP0000569_abnormal_digit_pigmentation1.97282700
24MP0003705_abnormal_hypodermis_morpholog1.95779930
25MP0005395_other_phenotype1.83828584
26MP0003646_muscle_fatigue1.83381954
27MP0004264_abnormal_extraembryonic_tissu1.78879230
28MP0001986_abnormal_taste_sensitivity1.74143839
29MP0002139_abnormal_hepatobiliary_system1.69886166
30MP0001968_abnormal_touch/_nociception1.68116676
31MP0002876_abnormal_thyroid_physiology1.63670759
32MP0004142_abnormal_muscle_tone1.61786470
33MP0005410_abnormal_fertilization1.61522657
34MP0005646_abnormal_pituitary_gland1.58413434
35MP0008872_abnormal_physiological_respon1.54045338
36MP0005253_abnormal_eye_physiology1.51532933
37MP0002653_abnormal_ependyma_morphology1.50967637
38MP0001666_abnormal_nutrient_absorption1.48856021
39MP0002837_dystrophic_cardiac_calcinosis1.44748338
40MP0002118_abnormal_lipid_homeostasis1.42734659
41MP0009745_abnormal_behavioral_response1.41816095
42MP0001501_abnormal_sleep_pattern1.38937223
43MP0008875_abnormal_xenobiotic_pharmacok1.37490660
44MP0006072_abnormal_retinal_apoptosis1.37038071
45MP0003878_abnormal_ear_physiology1.35264787
46MP0005377_hearing/vestibular/ear_phenot1.35264787
47MP0001984_abnormal_olfaction1.35134901
48MP0005670_abnormal_white_adipose1.34876452
49MP0004185_abnormal_adipocyte_glucose1.34480714
50MP0005666_abnormal_adipose_tissue1.34467131
51MP0002272_abnormal_nervous_system1.31392621
52MP0002160_abnormal_reproductive_system1.31338228
53MP0004133_heterotaxia1.29035192
54MP0004885_abnormal_endolymph1.28042447
55MP0001664_abnormal_digestion1.27797088
56MP0002736_abnormal_nociception_after1.27298017
57MP0003787_abnormal_imprinting1.23232531
58MP0009046_muscle_twitch1.23156972
59MP0003890_abnormal_embryonic-extraembry1.19394489
60MP0001485_abnormal_pinna_reflex1.16019581
61MP0002098_abnormal_vibrissa_morphology1.15478292
62MP0004924_abnormal_behavior1.14020586
63MP0005386_behavior/neurological_phenoty1.14020586
64MP0009764_decreased_sensitivity_to1.12627848
65MP0000490_abnormal_crypts_of1.11336107
66MP0002277_abnormal_respiratory_mucosa1.10624103
67MP0000639_abnormal_adrenal_gland1.09621255
68MP0003880_abnormal_central_pattern1.09493227
69MP0000631_abnormal_neuroendocrine_gland1.08692455
70MP0001486_abnormal_startle_reflex1.07948549
71MP0005389_reproductive_system_phenotype1.07841551
72MP0006276_abnormal_autonomic_nervous1.07674187
73MP0010329_abnormal_lipoprotein_level1.06558374
74MP0005501_abnormal_skin_physiology1.05147429
75MP0001663_abnormal_digestive_system1.05106797
76MP0002971_abnormal_brown_adipose1.03933270
77MP0005174_abnormal_tail_pigmentation1.00058055
78MP0005332_abnormal_amino_acid0.98503701
79MP0009384_cardiac_valve_regurgitation0.97691129
80MP0005584_abnormal_enzyme/coenzyme_acti0.97230401
81MP0000377_abnormal_hair_follicle0.97008329
82MP0002938_white_spotting0.96477000
83MP0005448_abnormal_energy_balance0.95045582
84MP0008775_abnormal_heart_ventricle0.94424189
85MP0002168_other_aberrant_phenotype0.92548902
86MP0001849_ear_inflammation0.91940362
87MP0003950_abnormal_plasma_membrane0.91541560
88MP0002735_abnormal_chemical_nociception0.90973937
89MP0005084_abnormal_gallbladder_morpholo0.90732409
90MP0005381_digestive/alimentary_phenotyp0.90158943
91MP0008789_abnormal_olfactory_epithelium0.90111640
92MP0000230_abnormal_systemic_arterial0.89065518
93MP0005375_adipose_tissue_phenotype0.87920583
94MP0004742_abnormal_vestibular_system0.87501865
95MP0004145_abnormal_muscle_electrophysio0.86533083
96MP0002163_abnormal_gland_morphology0.86270172
97MP0002638_abnormal_pupillary_reflex0.85157923
98MP0003656_abnormal_erythrocyte_physiolo0.84931282
99MP0003936_abnormal_reproductive_system0.84257187
100MP0002064_seizures0.84082802
101MP0001919_abnormal_reproductive_system0.83412151
102MP0005636_abnormal_mineral_homeostasis0.81968437
103MP0002572_abnormal_emotion/affect_behav0.81875297
104MP0000609_abnormal_liver_physiology0.80560391
105MP0000538_abnormal_urinary_bladder0.80367357
106MP0003119_abnormal_digestive_system0.79682902
107MP0002396_abnormal_hematopoietic_system0.79390860
108MP0005408_hypopigmentation0.79135082
109MP0002557_abnormal_social/conspecific_i0.78798096
110MP0002970_abnormal_white_adipose0.78394246
111MP0005167_abnormal_blood-brain_barrier0.78390827
112MP0010678_abnormal_skin_adnexa0.78206881
113MP0002095_abnormal_skin_pigmentation0.77521153
114MP0002067_abnormal_sensory_capabilities0.77321463
115MP0002733_abnormal_thermal_nociception0.76343571
116MP0006292_abnormal_olfactory_placode0.75851436
117MP0005451_abnormal_body_composition0.75009950
118MP0001905_abnormal_dopamine_level0.74094096
119MP0005195_abnormal_posterior_eye0.73457216
120MP0004272_abnormal_basement_membrane0.73231235
121MP0005334_abnormal_fat_pad0.72405209
122MP0005379_endocrine/exocrine_gland_phen0.71357019
123MP0003137_abnormal_impulse_conducting0.70179904
124MP0002332_abnormal_exercise_endurance0.70050716
125MP0003698_abnormal_male_reproductive0.69722816
126MP0002009_preneoplasia0.69268089
127MP0001970_abnormal_pain_threshold0.68522723
128MP0000613_abnormal_salivary_gland0.67950298
129MP0001765_abnormal_ion_homeostasis0.66299625
130MP0008770_decreased_survivor_rate0.66199143
131MP0010386_abnormal_urinary_bladder0.66057935
132MP0004947_skin_inflammation0.65660307
133MP0002078_abnormal_glucose_homeostasis0.65043313
134MP0002229_neurodegeneration0.65036647
135MP0005365_abnormal_bile_salt0.64952156
136MP0003699_abnormal_female_reproductive0.60092381
137MP0010352_gastrointestinal_tract_polyps0.60049319
138MP0001851_eye_inflammation0.59954886
139MP0003566_abnormal_cell_adhesion0.59078496
140MP0003453_abnormal_keratinocyte_physiol0.58696627
141MP0006054_spinal_hemorrhage0.58494609
142MP0005452_abnormal_adipose_tissue0.56540673
143MP0009643_abnormal_urine_homeostasis0.55810224
144MP0001216_abnormal_epidermal_layer0.54919231
145MP0003690_abnormal_glial_cell0.53479779
146MP0003448_altered_tumor_morphology0.53224077
147MP0003075_altered_response_to0.51418918
148MP0000678_abnormal_parathyroid_gland0.50807738
149MP0005076_abnormal_cell_differentiation0.50010447
150MP0005023_abnormal_wound_healing0.49554457
151MP0001958_emphysema0.47112027
152MP0002896_abnormal_bone_mineralization0.46847524
153MP0003123_paternal_imprinting0.46770076
154MP0001529_abnormal_vocalization0.46739218
155MP0005165_increased_susceptibility_to0.44894633
156MP0005319_abnormal_enzyme/_coenzyme0.44671033
157MP0002282_abnormal_trachea_morphology0.43235408
158MP0008438_abnormal_cutaneous_collagen0.41933103
159MP0005535_abnormal_body_temperature0.41143836
160MP0003959_abnormal_lean_body0.40394417
161MP0003045_fibrosis0.40282856
162MP0005164_abnormal_response_to0.39736615
163MP0008873_increased_physiological_sensi0.36943231
164MP0003329_amyloid_beta_deposits0.36906454
165MP0000579_abnormal_nail_morphology0.36092170
166MP0001756_abnormal_urination0.35643484
167MP0002102_abnormal_ear_morphology0.34965829
168MP0009931_abnormal_skin_appearance0.34942628
169MP0005275_abnormal_skin_tensile0.34298217
170MP0000013_abnormal_adipose_tissue0.33665598
171MP0010771_integument_phenotype0.33613095
172MP0000427_abnormal_hair_cycle0.31751718
173MP0009278_abnormal_bone_marrow0.30762835
174MP0002088_abnormal_embryonic_growth/wei0.29683763

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of purine metabolism (HP:0004352)6.86430158
2Axonal loss (HP:0003447)6.01974339
3Amelogenesis imperfecta (HP:0000705)5.83266646
4Gout (HP:0001997)5.82648563
5Congenital ichthyosiform erythroderma (HP:0007431)5.75467416
6Metaphyseal dysplasia (HP:0100255)5.08335414
7Thin bony cortex (HP:0002753)4.90671154
8Abnormality of calcium-phosphate metabolism (HP:0100530)4.42868301
9Congenital stationary night blindness (HP:0007642)4.37186359
10Abnormality of nucleobase metabolism (HP:0010932)4.21546494
11Pancreatic cysts (HP:0001737)4.18622842
12Ectropion (HP:0000656)3.98860688
13Molar tooth sign on MRI (HP:0002419)3.97120743
14Abnormality of midbrain morphology (HP:0002418)3.97120743
15Enlarged epiphyses (HP:0010580)3.95536159
16Overgrowth (HP:0001548)3.82846945
17Stridor (HP:0010307)3.74865354
18Tubulointerstitial nephritis (HP:0001970)3.70202187
19Pancreatic fibrosis (HP:0100732)3.61329348
20Decreased circulating renin level (HP:0003351)3.58681245
21True hermaphroditism (HP:0010459)3.57340096
22Nephritis (HP:0000123)3.52678277
23Neurodegeneration (HP:0002180)3.49762299
24Abnormality of renal resorption (HP:0011038)3.48256778
25Abnormality of renal excretion (HP:0011036)3.42502796
26Pili torti (HP:0003777)3.38494980
27Cortical dysplasia (HP:0002539)3.36754547
28Curly hair (HP:0002212)3.34275569
29Protuberant abdomen (HP:0001538)3.32988104
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.25579810
31Subcapsular cataract (HP:0000523)3.24333906
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.23626477
33Abnormality of the renal cortex (HP:0011035)3.22201610
34Hyperglycinemia (HP:0002154)3.20998049
35Tubulointerstitial fibrosis (HP:0005576)3.20836845
36Nephronophthisis (HP:0000090)3.20029799
37Pendular nystagmus (HP:0012043)3.19262097
38Birth length less than 3rd percentile (HP:0003561)3.12995188
39Type II lissencephaly (HP:0007260)3.12628754
40Abnormality of the renal medulla (HP:0100957)3.08811808
41Aortic aneurysm (HP:0004942)3.02438109
42Ketoacidosis (HP:0001993)2.93776184
43Abnormal auditory evoked potentials (HP:0006958)2.92538300
44Arterial tortuosity (HP:0005116)2.91497791
45Epiphyseal dysplasia (HP:0002656)2.89809113
46Glomerulosclerosis (HP:0000096)2.84946082
47Attenuation of retinal blood vessels (HP:0007843)2.81098839
48Increased purine levels (HP:0004368)2.79058461
49Hyperuricemia (HP:0002149)2.79058461
50Hyperventilation (HP:0002883)2.77462530
51Hyperglycinuria (HP:0003108)2.70896961
52Deep venous thrombosis (HP:0002625)2.65424665
53Bone cyst (HP:0012062)2.64137050
54Widely patent fontanelles and sutures (HP:0004492)2.62650002
55Postnatal microcephaly (HP:0005484)2.60434079
56Vascular tortuosity (HP:0004948)2.58700251
57Inability to walk (HP:0002540)2.58122367
58Abnormality of transition element cation homeostasis (HP:0011030)2.57770891
59Abnormal biliary tract physiology (HP:0012439)2.53778000
60Bile duct proliferation (HP:0001408)2.53778000
61Increased serum pyruvate (HP:0003542)2.52740352
62Abnormality of glycolysis (HP:0004366)2.52740352
63Aortic dissection (HP:0002647)2.50533846
64Abnormality of the costochondral junction (HP:0000919)2.48068691
65Chorioretinal atrophy (HP:0000533)2.46540868
66Progressive inability to walk (HP:0002505)2.43567446
67Autoamputation (HP:0001218)2.41897933
68Tubular atrophy (HP:0000092)2.41784015
69Wide cranial sutures (HP:0010537)2.41742950
70Progressive cerebellar ataxia (HP:0002073)2.38653009
71Cystic liver disease (HP:0006706)2.37268872
72Chronic hepatic failure (HP:0100626)2.37262465
73Polydipsia (HP:0001959)2.37113914
74Abnormal drinking behavior (HP:0030082)2.37113914
75Congenital sensorineural hearing impairment (HP:0008527)2.37029588
76Turricephaly (HP:0000262)2.36025997
77Abnormality of vision evoked potentials (HP:0000649)2.35639837
78Enlarged penis (HP:0000040)2.35612049
79Large for gestational age (HP:0001520)2.34719151
803-Methylglutaconic aciduria (HP:0003535)2.34031674
81Genetic anticipation (HP:0003743)2.33379497
82Right ventricular cardiomyopathy (HP:0011663)2.33233828
83Delayed epiphyseal ossification (HP:0002663)2.32383895
84Renal salt wasting (HP:0000127)2.31753198
85Medial flaring of the eyebrow (HP:0010747)2.31158555
86Congenital, generalized hypertrichosis (HP:0004540)2.28663749
87Cerebral aneurysm (HP:0004944)2.25770267
88Ketosis (HP:0001946)2.25356560
89Long toe (HP:0010511)2.23903793
90Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23608701
91Lissencephaly (HP:0001339)2.22316559
92Sclerocornea (HP:0000647)2.21825743
93Abnormality of dental color (HP:0011073)2.21404664
94Spastic paraparesis (HP:0002313)2.21337103
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16872774
96Poor eye contact (HP:0000817)2.16531864
97Biliary tract neoplasm (HP:0100574)2.16184519
98Abnormality of serine family amino acid metabolism (HP:0010894)2.14537205
99Abnormality of glycine metabolism (HP:0010895)2.14537205
100Abnormality of alanine metabolism (HP:0010916)2.14502500
101Hyperalaninemia (HP:0003348)2.14502500
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14502500
103Hypokalemic alkalosis (HP:0001949)2.13297775
104Methylmalonic aciduria (HP:0012120)2.12622395
105Keratoconus (HP:0000563)2.12531116
106Increased corneal curvature (HP:0100692)2.12531116
107Polyuria (HP:0000103)2.11691710
108Irritability (HP:0000737)2.10845425
109Nephrolithiasis (HP:0000787)2.10646447
110Abnormal rod and cone electroretinograms (HP:0008323)2.10154380
111Methylmalonic acidemia (HP:0002912)2.09798058
112Furrowed tongue (HP:0000221)2.08738544
113Hypoplasia of dental enamel (HP:0006297)2.08620141
114Abnormality of the pons (HP:0007361)2.08049964
115Erythroderma (HP:0001019)2.07944483
116Cortical visual impairment (HP:0100704)2.07468278
117Decreased central vision (HP:0007663)2.06210929
118Premature loss of primary teeth (HP:0006323)2.03568780
119Abdominal distention (HP:0003270)2.03079603
120Hypoplasia of the pons (HP:0012110)2.02469156
121Microretrognathia (HP:0000308)2.02253400
122Abnormality of the dental pulp (HP:0006479)2.02170731
123Mitochondrial inheritance (HP:0001427)2.01577822
124Osteolytic defects of the phalanges of the hand (HP:0009771)2.00409491
125Osteolytic defects of the hand bones (HP:0009699)2.00409491
126Aneurysm (HP:0002617)1.99896550
127Gaze-evoked nystagmus (HP:0000640)1.99326585
128Conjunctival hamartoma (HP:0100780)1.97570666
129Stomatitis (HP:0010280)1.97478509
130Abnormality of renin-angiotensin system (HP:0000847)1.97426551
131Abnormality of the intrinsic pathway (HP:0010989)1.96306076
132Aplasia/hypoplasia of the uterus (HP:0008684)1.96095925
133Bilateral microphthalmos (HP:0007633)1.95949536
134Male pseudohermaphroditism (HP:0000037)1.95938013
135Striae distensae (HP:0001065)1.95849912
136Symptomatic seizures (HP:0011145)1.95757825
137Hyperactive renin-angiotensin system (HP:0000841)1.95321498
138Male infertility (HP:0003251)1.95001286
139Increased CSF lactate (HP:0002490)1.94686806
140Posterior subcapsular cataract (HP:0007787)1.93082674
141Epidermoid cyst (HP:0200040)1.92392117
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91900244
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.90159602
144Acute encephalopathy (HP:0006846)1.89973885
145Abnormal hair laboratory examination (HP:0003328)1.89666954
146Insulin-resistant diabetes mellitus (HP:0000831)1.89431992
147Asymmetry of the thorax (HP:0001555)1.89000983
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88133778
149Anencephaly (HP:0002323)1.87030748
150Rickets (HP:0002748)1.85058515
151Optic disc pallor (HP:0000543)1.83716290
152Renal cortical cysts (HP:0000803)1.83605571
153Polar cataract (HP:0010696)1.82940098
154Hyperaldosteronism (HP:0000859)1.82061221
155Abnormality of the anterior chamber (HP:0000593)1.81774487
156Acute necrotizing encephalopathy (HP:0006965)1.79994830
157Hypoplasia of the uterus (HP:0000013)1.79809647
158Cerebellar dysplasia (HP:0007033)1.79708826
159Peripheral demyelination (HP:0011096)1.78199412
160Hemiparesis (HP:0001269)1.78087434
161Optic nerve hypoplasia (HP:0000609)1.77908065
162Impaired social interactions (HP:0000735)1.77870884
163Abnormal social behavior (HP:0012433)1.77870884
164Severe muscular hypotonia (HP:0006829)1.77305698
165Agitation (HP:0000713)1.77264121
166Abolished electroretinogram (ERG) (HP:0000550)1.76461341
167Premature skin wrinkling (HP:0100678)1.76457386
168Bony spicule pigmentary retinopathy (HP:0007737)1.75904433
169Concave nail (HP:0001598)1.75899337
170Hepatocellular necrosis (HP:0001404)1.75887888
171Gait imbalance (HP:0002141)1.75705911
172Ankle clonus (HP:0011448)1.75342734
173Increased serum ferritin (HP:0003281)1.74634039
174Peripheral hypomyelination (HP:0007182)1.73271155
175Patellar aplasia (HP:0006443)1.72777490
176Tachypnea (HP:0002789)1.72414877
177Spastic tetraparesis (HP:0001285)1.72266514
178Alkalosis (HP:0001948)1.72237702
179Dynein arm defect of respiratory motile cilia (HP:0012255)1.71582164
180Absent/shortened dynein arms (HP:0200106)1.71582164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D5.43149973
2PKN25.08978677
3EEF2K4.98191417
4SIK14.42460971
5CAMK1G4.14998848
6BMPR1B3.68096157
7TRIB33.67878913
8ACVR1B3.58446861
9GRK13.49607736
10ADRBK23.33469105
11MAPKAPK32.83300175
12PDK32.77250878
13PDK42.77250878
14PINK12.56804349
15INSRR2.52862700
16WNK32.39586629
17LATS12.35041958
18ERN12.19447708
19MAP4K22.10328997
20PDK21.98305686
21CASK1.97765250
22TXK1.97232861
23ZAK1.92755977
24PTK61.85938537
25NME21.85483780
26TAOK31.84654013
27CAMKK21.79124166
28PRKAA21.74878668
29BCKDK1.70291543
30PIK3CA1.69880411
31OXSR11.66687800
32PDGFRB1.64952558
33RIPK11.63385990
34STK38L1.58367531
35MAP2K61.57312455
36MAPKAPK51.56298991
37RET1.51156665
38MAP3K41.51150157
39KSR21.50977711
40NUAK11.45260075
41TGFBR21.44023061
42TLK11.43418996
43MAP3K61.42291880
44TGFBR11.39581078
45TRPM71.39108489
46STK381.38727650
47EIF2AK31.37847422
48ADRBK11.35673377
49RPS6KB21.34677341
50ZAP701.32032772
51MAP3K91.31828186
52MKNK21.24176144
53PNCK1.23809520
54TRIM281.23474602
55ERBB41.23361427
56MAP3K71.23009959
57MAP2K71.17392068
58DYRK21.16813009
59MAPK151.15913667
60PRKCG1.11998106
61TSSK61.11753344
62LATS21.11484531
63PHKG21.10916489
64PHKG11.10916489
65IRAK11.10647090
66STK391.07502655
67PAK31.06120612
68EPHB11.02365602
69LRRK20.96601857
70MAP3K130.91954682
71PRKCE0.89548491
72PRKAA10.85866581
73WNK40.84986371
74BCR0.84296980
75MAPK120.83628680
76EPHA30.82854986
77BRSK20.80628680
78DAPK20.80090175
79STK30.78793359
80TIE10.78367546
81NME10.75341272
82DDR20.73871210
83TYRO30.72700417
84NTRK20.71875347
85STK160.70651079
86MARK10.69873536
87PIK3CG0.68211039
88NEK90.66982219
89JAK20.66712363
90IKBKB0.66495328
91CHUK0.66458840
92GRK70.64648453
93BMX0.63848400
94PTK20.62442096
95MAPK110.61517764
96RPS6KA50.61451601
97FRK0.61448511
98CAMK2A0.57401880
99FGR0.53455095
100MKNK10.52272038
101TAOK10.52257636
102PRKCQ0.52068386
103MAPK130.50972951
104MAP3K20.50503823
105MAP2K10.49704374
106PIM10.48708711
107TBK10.48278563
108GSK3A0.48179559
109PLK20.47215140
110VRK10.44883504
111IGF1R0.44834926
112PDPK10.44159406
113ARAF0.43899519
114RAF10.43794901
115PAK60.43686665
116ERBB30.43601527
117PRKCI0.43540090
118PRKACA0.43228621
119TEC0.43127631
120TNK20.42708933
121PDK10.42167176
122CAMK10.41685079
123MOS0.41162540
124ITK0.40829021
125FER0.39509683
126FLT30.38918452
127JAK30.38310611
128BTK0.38131464
129PLK40.37937452
130CSNK1G20.37438370
131STK110.37063263
132SGK2230.36033847
133SGK4940.36033847
134MET0.35460570
135BMPR20.35224521
136CSNK1A10.34649087
137NTRK30.33841031
138WEE10.33421935
139EIF2AK20.33302206
140KIT0.33247638
141CDK90.33225090
142PRKCA0.33081566
143MAP2K40.32326412
144JAK10.32273047
145RPS6KA20.31673143
146CSNK1G30.31284753
147DYRK30.30185550
148CSF1R0.29794788
149EIF2AK10.29616978
150TNIK0.29604894
151CSNK1G10.28807766
152LYN0.28181984
153RPS6KA60.27621201
154RPS6KB10.27561567
155EPHA40.27066736
156MTOR0.26982729
157CSNK2A20.25471384
158MAP3K10.24796477
159PRKD10.23737387
160BRAF0.22871642
161KSR10.22392516
162MATK0.21317419
163PRKCZ0.21141404
164PDGFRA0.21065787
165CDK80.20260233
166MUSK0.20138630
167CAMKK10.16521471
168PTK2B0.15799431
169EGFR0.15660184
170STK100.13147140
171PRKD30.12824466
172MELK0.11787428
173MYLK0.11561357
174SRC0.09732016
175ABL10.09335437
176ILK0.08343600
177ABL20.06676779

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fatty acid biosynthesis_Homo sapiens_hsa000615.10361511
2Galactose metabolism_Homo sapiens_hsa000523.92455238
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.75656470
4Nitrogen metabolism_Homo sapiens_hsa009102.97592880
5Fatty acid metabolism_Homo sapiens_hsa012122.90481716
6Propanoate metabolism_Homo sapiens_hsa006402.75742424
7Pyruvate metabolism_Homo sapiens_hsa006202.73417007
8Prolactin signaling pathway_Homo sapiens_hsa049172.34283409
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34045501
10Caffeine metabolism_Homo sapiens_hsa0023210.0532265
11Linoleic acid metabolism_Homo sapiens_hsa005911.96495009
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89673748
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.83770820
14PPAR signaling pathway_Homo sapiens_hsa033201.78159355
15Phototransduction_Homo sapiens_hsa047441.65545109
16Steroid biosynthesis_Homo sapiens_hsa001001.62796052
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60733183
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56029096
19Ether lipid metabolism_Homo sapiens_hsa005651.53701845
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.47690565
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38707302
22Oxidative phosphorylation_Homo sapiens_hsa001901.34621899
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.33061777
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32088976
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23362243
26N-Glycan biosynthesis_Homo sapiens_hsa005101.23355187
27Fatty acid elongation_Homo sapiens_hsa000621.19034006
28Sulfur relay system_Homo sapiens_hsa041221.17924026
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15727903
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14913270
31Protein export_Homo sapiens_hsa030601.14102300
32Fatty acid degradation_Homo sapiens_hsa000711.06237140
33Nicotine addiction_Homo sapiens_hsa050331.03493312
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.02876944
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02547947
36Parkinsons disease_Homo sapiens_hsa050120.96172015
37Carbon metabolism_Homo sapiens_hsa012000.91795230
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91229749
39RNA polymerase_Homo sapiens_hsa030200.90991903
40beta-Alanine metabolism_Homo sapiens_hsa004100.88405523
41Folate biosynthesis_Homo sapiens_hsa007900.87217553
42Histidine metabolism_Homo sapiens_hsa003400.87101493
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86247956
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85450995
45Selenocompound metabolism_Homo sapiens_hsa004500.84034498
46Arachidonic acid metabolism_Homo sapiens_hsa005900.83437765
47AMPK signaling pathway_Homo sapiens_hsa041520.83370514
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.83192128
49Peroxisome_Homo sapiens_hsa041460.82892697
50One carbon pool by folate_Homo sapiens_hsa006700.82104609
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81009345
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.79732734
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79363997
54Fat digestion and absorption_Homo sapiens_hsa049750.78417048
55Arginine biosynthesis_Homo sapiens_hsa002200.77635426
56Glycerolipid metabolism_Homo sapiens_hsa005610.76440064
57Morphine addiction_Homo sapiens_hsa050320.76390199
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70697267
59Basal transcription factors_Homo sapiens_hsa030220.69929159
60Insulin resistance_Homo sapiens_hsa049310.68925327
61Olfactory transduction_Homo sapiens_hsa047400.68234541
62Pancreatic cancer_Homo sapiens_hsa052120.66543209
63Taste transduction_Homo sapiens_hsa047420.64926708
64Vitamin digestion and absorption_Homo sapiens_hsa049770.62143054
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.60102518
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58172230
67Pentose phosphate pathway_Homo sapiens_hsa000300.56824454
68Purine metabolism_Homo sapiens_hsa002300.55903634
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.55841054
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55739638
71ABC transporters_Homo sapiens_hsa020100.55189775
72Huntingtons disease_Homo sapiens_hsa050160.54764701
73Chemical carcinogenesis_Homo sapiens_hsa052040.53369459
74Salivary secretion_Homo sapiens_hsa049700.53174976
75Homologous recombination_Homo sapiens_hsa034400.53132599
76Collecting duct acid secretion_Homo sapiens_hsa049660.53102120
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52227952
78GABAergic synapse_Homo sapiens_hsa047270.52199392
79Alzheimers disease_Homo sapiens_hsa050100.51353316
80mTOR signaling pathway_Homo sapiens_hsa041500.51096071
81Mineral absorption_Homo sapiens_hsa049780.51008145
82Biosynthesis of amino acids_Homo sapiens_hsa012300.50850503
83Butanoate metabolism_Homo sapiens_hsa006500.48944060
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46816908
85Regulation of autophagy_Homo sapiens_hsa041400.45484729
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45180731
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45101001
88Insulin signaling pathway_Homo sapiens_hsa049100.44793190
89Fanconi anemia pathway_Homo sapiens_hsa034600.44695926
90VEGF signaling pathway_Homo sapiens_hsa043700.44222021
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43947086
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43367294
93Cardiac muscle contraction_Homo sapiens_hsa042600.43010866
94Glucagon signaling pathway_Homo sapiens_hsa049220.43007589
95Serotonergic synapse_Homo sapiens_hsa047260.42543339
96Circadian entrainment_Homo sapiens_hsa047130.41528449
97Sulfur metabolism_Homo sapiens_hsa009200.40535970
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.39615086
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39312927
100Gastric acid secretion_Homo sapiens_hsa049710.38473224
101Circadian rhythm_Homo sapiens_hsa047100.38249342
102Insulin secretion_Homo sapiens_hsa049110.37982035
103Glutamatergic synapse_Homo sapiens_hsa047240.37083873
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36316756
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35782686
106Amoebiasis_Homo sapiens_hsa051460.35250975
107Ovarian steroidogenesis_Homo sapiens_hsa049130.33329935
108Chronic myeloid leukemia_Homo sapiens_hsa052200.31763103
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.31731201
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30315734
111Hepatitis C_Homo sapiens_hsa051600.30152494
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29641731
113RNA degradation_Homo sapiens_hsa030180.29419560
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28873028
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28431941
116Retinol metabolism_Homo sapiens_hsa008300.28058117
117Renal cell carcinoma_Homo sapiens_hsa052110.27542142
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27277039
119Bile secretion_Homo sapiens_hsa049760.25904672
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25568079
121Endocytosis_Homo sapiens_hsa041440.25233341
122Toxoplasmosis_Homo sapiens_hsa051450.24787737
123Colorectal cancer_Homo sapiens_hsa052100.24746355
124Pancreatic secretion_Homo sapiens_hsa049720.24606448
125Dorso-ventral axis formation_Homo sapiens_hsa043200.22922077
126Acute myeloid leukemia_Homo sapiens_hsa052210.21634640
127Tight junction_Homo sapiens_hsa045300.20739699
128Bladder cancer_Homo sapiens_hsa052190.20244815
129Ribosome_Homo sapiens_hsa030100.20092635
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19995297
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19808840
132Calcium signaling pathway_Homo sapiens_hsa040200.19135483
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18890352
134Arginine and proline metabolism_Homo sapiens_hsa003300.18433029
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17861723
136Glutathione metabolism_Homo sapiens_hsa004800.17700157
137Starch and sucrose metabolism_Homo sapiens_hsa005000.17588829
138Dopaminergic synapse_Homo sapiens_hsa047280.17336823
139Choline metabolism in cancer_Homo sapiens_hsa052310.16474611
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16275396
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16152776
142HIF-1 signaling pathway_Homo sapiens_hsa040660.15321782
143Lysosome_Homo sapiens_hsa041420.15190945
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14927662
145ECM-receptor interaction_Homo sapiens_hsa045120.14810649
146Small cell lung cancer_Homo sapiens_hsa052220.12329035
147Hepatitis B_Homo sapiens_hsa051610.11675412
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.11587095
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11468322
150ErbB signaling pathway_Homo sapiens_hsa040120.11115041
151Endometrial cancer_Homo sapiens_hsa052130.10876375
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09615289
153Rheumatoid arthritis_Homo sapiens_hsa053230.09143649
154Tryptophan metabolism_Homo sapiens_hsa003800.08935416
155FoxO signaling pathway_Homo sapiens_hsa040680.08919726
156Estrogen signaling pathway_Homo sapiens_hsa049150.08480044
157* Metabolic pathways_Homo sapiens_hsa011000.08432956
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08040670
159GnRH signaling pathway_Homo sapiens_hsa049120.07931209
160Focal adhesion_Homo sapiens_hsa045100.07877639
161Vibrio cholerae infection_Homo sapiens_hsa051100.06911832
162Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06598821
163Phospholipase D signaling pathway_Homo sapiens_hsa040720.05113467
164Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05005301
165SNARE interactions in vesicular transport_Homo sapiens_hsa041300.04921308
166Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.04475871

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