OGFRL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)6.16432046
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.52463120
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.43567483
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.43567483
5modulation by symbiont of host immune response (GO:0052553)5.43567483
6positive regulation by symbiont of host defense response (GO:0052509)5.43567483
7modulation by symbiont of host defense response (GO:0052031)5.43567483
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.43567483
9detection of molecule of bacterial origin (GO:0032490)5.36082055
10presynaptic membrane assembly (GO:0097105)5.34827419
11vocalization behavior (GO:0071625)5.16572902
12macrophage activation involved in immune response (GO:0002281)5.13505352
13neuron cell-cell adhesion (GO:0007158)5.06120826
14ionotropic glutamate receptor signaling pathway (GO:0035235)5.03990148
15positive regulation of gamma-delta T cell activation (GO:0046645)5.01903163
16protein localization to synapse (GO:0035418)4.95039181
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88322652
18response to peptidoglycan (GO:0032494)4.78358955
19presynaptic membrane organization (GO:0097090)4.74864572
20postsynaptic membrane organization (GO:0001941)4.59617531
21glutamate receptor signaling pathway (GO:0007215)4.52589728
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.49485780
23synaptic vesicle exocytosis (GO:0016079)4.48430843
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.48077014
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.47907915
26regulation of glutamate receptor signaling pathway (GO:1900449)4.42614430
27regulation of short-term neuronal synaptic plasticity (GO:0048172)4.41040386
28microglial cell activation (GO:0001774)4.35127579
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.33902818
30neutrophil activation involved in immune response (GO:0002283)4.31746957
31negative regulation of interleukin-12 production (GO:0032695)4.30994194
32detection of external biotic stimulus (GO:0098581)4.23867839
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22805406
34detection of other organism (GO:0098543)4.17969874
35regulation of interferon-beta biosynthetic process (GO:0045357)4.17343995
36macrophage activation (GO:0042116)4.04703342
37synaptic transmission, glutamatergic (GO:0035249)3.98612307
38cellular extravasation (GO:0045123)3.94983010
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93640126
40neuron-neuron synaptic transmission (GO:0007270)3.92046674
41gamma-aminobutyric acid transport (GO:0015812)3.91715421
42locomotory exploration behavior (GO:0035641)3.90969092
43positive regulation of membrane potential (GO:0045838)3.90542445
44response to host immune response (GO:0052572)3.82228678
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82228678
46regulation of synaptic vesicle exocytosis (GO:2000300)3.76712044
47long-term memory (GO:0007616)3.73360606
48detection of biotic stimulus (GO:0009595)3.73090049
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70761271
50positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.70453746
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69950671
52regulation of postsynaptic membrane potential (GO:0060078)3.66782544
53glutamate secretion (GO:0014047)3.64588163
54regulation of B cell receptor signaling pathway (GO:0050855)3.62296212
55transmission of nerve impulse (GO:0019226)3.58088640
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.58012727
57response to host (GO:0075136)3.58012727
58response to host defenses (GO:0052200)3.58012727
59positive regulation of cellular amide metabolic process (GO:0034250)3.55955132
60synaptic vesicle maturation (GO:0016188)3.52992547
61detection of bacterium (GO:0016045)3.52019403
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.51963818
63neuron recognition (GO:0008038)3.51050881
64regulation of gamma-delta T cell activation (GO:0046643)3.50597122
65exploration behavior (GO:0035640)3.48858284
66neurotransmitter secretion (GO:0007269)3.45051161
67myeloid cell activation involved in immune response (GO:0002275)3.42620442
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42208532
69regulation of protein kinase A signaling (GO:0010738)3.41768736
70lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40945622
71regulation of synaptic vesicle transport (GO:1902803)3.40088374
72regulation of vesicle fusion (GO:0031338)3.39201252
73regulation of neuronal synaptic plasticity (GO:0048168)3.36042015
74antigen processing and presentation of endogenous antigen (GO:0019883)3.35934963
75neurotransmitter-gated ion channel clustering (GO:0072578)3.35524945
76neutrophil mediated immunity (GO:0002446)3.33589041
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32894605
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.32530821
79positive regulation of macrophage cytokine production (GO:0060907)3.31613179
80positive regulation of dendritic spine development (GO:0060999)3.31511511
81neutrophil activation (GO:0042119)3.29013376
82short-term memory (GO:0007614)3.26918443
83response to muramyl dipeptide (GO:0032495)3.26762580
84regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25802349
85regulation of mast cell degranulation (GO:0043304)3.24029506
86regulation of macrophage cytokine production (GO:0010935)3.23307551
87positive regulation of mast cell activation (GO:0033005)3.22588056
88granulocyte activation (GO:0036230)3.18918949
89response to histamine (GO:0034776)3.18548226
90membrane depolarization (GO:0051899)3.17687038
91dendritic spine morphogenesis (GO:0060997)3.17639320
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.17281470
93righting reflex (GO:0060013)3.16989693
94regulation of T-helper 2 cell differentiation (GO:0045628)3.15219669
95startle response (GO:0001964)3.14265455
96negative regulation of lymphocyte mediated immunity (GO:0002707)3.13510838
97regulation of leukocyte degranulation (GO:0043300)3.12791015
98regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12130149
99positive regulation of dendritic spine morphogenesis (GO:0061003)3.11780115
100neurotransmitter transport (GO:0006836)3.11164606
101regulation of synaptic transmission, GABAergic (GO:0032228)3.10173192
102positive regulation of synapse assembly (GO:0051965)3.09763359
103negative regulation of T cell mediated immunity (GO:0002710)3.09063622
104synapse assembly (GO:0007416)3.08669568
105leukocyte aggregation (GO:0070486)3.08086638
106regulation of synaptic transmission, glutamatergic (GO:0051966)3.07831558
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07640851
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06004646
109regulation of dendritic spine development (GO:0060998)3.05667786
110T-helper 1 type immune response (GO:0042088)3.05305711
111germinal center formation (GO:0002467)3.04962252
112positive regulation of neurotransmitter secretion (GO:0001956)3.04929954
113regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04619122
114negative regulation of interleukin-17 production (GO:0032700)3.03855730
115regulation of dendritic spine morphogenesis (GO:0061001)3.03003569
116regulation of mast cell activation involved in immune response (GO:0033006)3.00964300
117production of molecular mediator involved in inflammatory response (GO:0002532)2.99812644
118positive regulation of mast cell activation involved in immune response (GO:0033008)2.98768067
119positive regulation of mast cell degranulation (GO:0043306)2.98768067
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98226166
121positive regulation of interferon-alpha production (GO:0032727)2.97773889
122regulation of gamma-delta T cell differentiation (GO:0045586)2.97703078
123regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97179757
124regulation of interferon-alpha production (GO:0032647)2.96801050
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96350084
126negative regulation of erythrocyte differentiation (GO:0045647)2.96281016
127regulation of synaptic plasticity (GO:0048167)2.95415177
128immunoglobulin mediated immune response (GO:0016064)2.95224525
129cerebellar Purkinje cell differentiation (GO:0021702)2.94774103
130myeloid leukocyte mediated immunity (GO:0002444)2.92668531
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90392952
132negative regulation of leukocyte mediated immunity (GO:0002704)2.90356974
133adult walking behavior (GO:0007628)2.89880828
134learning (GO:0007612)2.89195584
135long-term synaptic potentiation (GO:0060291)2.88127192
136regulation of glutamate secretion (GO:0014048)2.86197242
137respiratory burst (GO:0045730)2.85360243
138regulation of mast cell activation (GO:0033003)2.85121036
139regulation of neurotransmitter secretion (GO:0046928)2.83907988
140positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82619035
141regulation of neurotransmitter levels (GO:0001505)2.82013900
142cerebellar granule cell differentiation (GO:0021707)2.81837383
143neuron remodeling (GO:0016322)2.81068677
144G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.80961101
145positive regulation of toll-like receptor signaling pathway (GO:0034123)2.80642535
146negative regulation of type 2 immune response (GO:0002829)2.79911941
147interferon-gamma-mediated signaling pathway (GO:0060333)2.78285732
148regulation of regulated secretory pathway (GO:1903305)2.78080570
149B cell receptor signaling pathway (GO:0050853)2.77957090
150defense response to protozoan (GO:0042832)2.77866184
151neuromuscular process controlling posture (GO:0050884)2.77849708
152axonal fasciculation (GO:0007413)2.77201465
153positive regulation of leukocyte degranulation (GO:0043302)2.73774139
154membrane hyperpolarization (GO:0060081)2.73701542
155negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.73331337
156positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72397333
157mating behavior (GO:0007617)2.72124120
158detection of calcium ion (GO:0005513)2.72097934
159serotonin receptor signaling pathway (GO:0007210)2.71394673
160L-amino acid import (GO:0043092)2.71174952
161behavioral response to cocaine (GO:0048148)2.69532724
162positive regulation of neurotransmitter transport (GO:0051590)2.69361662
163membrane assembly (GO:0071709)2.68861903
164layer formation in cerebral cortex (GO:0021819)2.68504490
165myeloid leukocyte activation (GO:0002274)2.66966800
166regulation of beta-amyloid formation (GO:1902003)2.66862025
167synaptic transmission (GO:0007268)2.66708879
168antigen processing and presentation via MHC class Ib (GO:0002475)2.66644472
169type I interferon signaling pathway (GO:0060337)2.66398485
170cellular response to type I interferon (GO:0071357)2.66398485
171behavioral defense response (GO:0002209)2.66326316
172behavioral fear response (GO:0001662)2.66326316
173response to interleukin-15 (GO:0070672)2.66051481
174intraspecies interaction between organisms (GO:0051703)2.64906956
175social behavior (GO:0035176)2.64906956
176regulation of synapse structural plasticity (GO:0051823)2.64539529
177response to type I interferon (GO:0034340)2.63943786
178regulation of synapse assembly (GO:0051963)2.63721420
179regulation of respiratory system process (GO:0044065)2.62929388
180mechanosensory behavior (GO:0007638)2.62676547
181regulation of synaptic transmission (GO:0050804)2.60865527
182negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60106190
183fear response (GO:0042596)2.59810877
184negative regulation of cell killing (GO:0031342)2.59405995
185negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59405995
186positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.59118379
187neutrophil chemotaxis (GO:0030593)2.57400270
188protein localization to endosome (GO:0036010)2.55481771
189regulation of interleukin-8 biosynthetic process (GO:0045414)2.55451498
190regulation of type 2 immune response (GO:0002828)2.54699018
191response to protozoan (GO:0001562)2.54290399
192positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54214997
193regulation of tolerance induction (GO:0002643)2.54070376
194regulation of amyloid precursor protein catabolic process (GO:1902991)2.51958286
195negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51669850
196neutrophil migration (GO:1990266)2.50556430
197negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.49967892
198positive regulation of type 2 immune response (GO:0002830)2.49605705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.35422284
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.38792720
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.06150713
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.83411287
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.70070735
6GBX2_23144817_ChIP-Seq_PC3_Human3.64590448
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.38614441
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36028010
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29493352
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.28544215
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12377700
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08520297
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03180002
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00586535
15TAF15_26573619_Chip-Seq_HEK293_Human2.93144737
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89716310
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84829335
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.75960681
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73822573
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70616425
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63154437
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63043267
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63043267
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60025328
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56439165
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.51817817
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.45374680
28AR_21572438_ChIP-Seq_LNCaP_Human2.37175262
29RUNX_20019798_ChIP-Seq_JUKART_Human2.35486968
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33098954
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32692375
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29596284
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24266108
34SPI1_23127762_ChIP-Seq_K562_Human2.23445846
35SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18788291
36* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15671883
37EGR1_19374776_ChIP-ChIP_THP-1_Human2.14828792
38SCL_19346495_ChIP-Seq_HPC-7_Human2.13511612
39VDR_24787735_ChIP-Seq_THP-1_Human2.12734153
40EZH2_27294783_Chip-Seq_ESCs_Mouse2.12365514
41REST_21632747_ChIP-Seq_MESCs_Mouse2.08189479
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07251818
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05695048
44RNF2_27304074_Chip-Seq_ESCs_Mouse2.04097376
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01500839
46VDR_24763502_ChIP-Seq_THP-1_Human2.01327479
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01019887
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99510902
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97126901
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95852805
51* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94777299
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90336053
53IGF1R_20145208_ChIP-Seq_DFB_Human1.83405509
54SPI1_23547873_ChIP-Seq_NB4_Human1.82801101
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79592378
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78931776
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78100091
58DROSHA_22980978_ChIP-Seq_HELA_Human1.77898173
59P300_19829295_ChIP-Seq_ESCs_Human1.76997130
60SMAD4_21799915_ChIP-Seq_A2780_Human1.71322669
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.71123269
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68787593
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68712594
64GATA1_22025678_ChIP-Seq_K562_Human1.68186105
65VDR_21846776_ChIP-Seq_THP-1_Human1.66259165
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64495930
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.60419083
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.59156973
69TCF7_22412390_ChIP-Seq_EML_Mouse1.55732073
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55114526
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.53787578
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53426319
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53118068
74MYB_26560356_Chip-Seq_TH2_Human1.52926954
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.52805976
76* RARB_27405468_Chip-Seq_BRAIN_Mouse1.50405947
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50147003
78* GATA2_21666600_ChIP-Seq_HMVEC_Human1.48565692
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48496868
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47278438
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.47168637
82* PU_27001747_Chip-Seq_BMDM_Mouse1.46898429
83VDR_22108803_ChIP-Seq_LS180_Human1.46709321
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.45094149
85MAF_26560356_Chip-Seq_TH1_Human1.45021898
86* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43786414
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43393970
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43356243
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42613352
90RNF2_27304074_Chip-Seq_NSC_Mouse1.41376975
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41310415
92ER_23166858_ChIP-Seq_MCF-7_Human1.39794000
93AR_25329375_ChIP-Seq_VCAP_Human1.39534636
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39140172
95KDM2B_26808549_Chip-Seq_DND41_Human1.38050955
96FUS_26573619_Chip-Seq_HEK293_Human1.36368388
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34767039
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34319740
99* FLI1_27457419_Chip-Seq_LIVER_Mouse1.32021345
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31760637
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29172771
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.29080933
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28254591
104* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23049435
105* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22822861
106MYB_26560356_Chip-Seq_TH1_Human1.22551640
107* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21826225
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21741806
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21550938
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20797534
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20670184
112* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20101412
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19963439
114* E2F1_18555785_Chip-Seq_ESCs_Mouse1.16302693
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15970561
116TP53_18474530_ChIP-ChIP_U2OS_Human1.15175334
117GATA1_19941826_ChIP-Seq_K562_Human1.14209392
118* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14200556
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13921116
120* P53_22387025_ChIP-Seq_ESCs_Mouse1.13605029
121STAT3_23295773_ChIP-Seq_U87_Human1.13249179
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12559128
123* GATA3_27048872_Chip-Seq_THYMUS_Human1.11581039
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11485604
125RUNX2_22187159_ChIP-Seq_PCA_Human1.11287826
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.10951011
127TCF4_23295773_ChIP-Seq_U87_Human1.10916226
128KDM2B_26808549_Chip-Seq_JURKAT_Human1.10027549
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09219963
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09003161
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08932219
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08792369
133UTX_26944678_Chip-Seq_JUKART_Human1.08216849
134* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08185431
135* CMYC_18555785_Chip-Seq_ESCs_Mouse1.07439610
136BCAT_22108803_ChIP-Seq_LS180_Human1.07283144
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06874352
138* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06338510
139* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05344596
140KDM2B_26808549_Chip-Seq_K562_Human1.04658584
141* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03443802
142NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03219851
143* P300_18555785_Chip-Seq_ESCs_Mouse1.03090228
144ESR2_21235772_ChIP-Seq_MCF-7_Human1.02736170
145* KDM2B_26808549_Chip-Seq_REH_Human1.02333155
146ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01439094
147CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01063664
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99910286
149TP53_16413492_ChIP-PET_HCT116_Human0.99780636
150* SOX2_18555785_Chip-Seq_ESCs_Mouse0.98969812
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.98348737
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98049611
153GATA2_19941826_ChIP-Seq_K562_Human0.97882484
154* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97794506
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.97526727
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97262500
157* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97249179
158* NMYC_18555785_Chip-Seq_ESCs_Mouse0.96802225
159CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96712059
160* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96269395
161* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96040694
162* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95912883
163ZNF274_21170338_ChIP-Seq_K562_Hela0.95844517
164TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94284524
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94284524
166P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94279125
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93966626
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.93739370
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93437757
170* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93178787
171LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91097426
172* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89693243
173ELK3_25401928_ChIP-Seq_HUVEC_Human0.89510971
174* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89257368
175* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89002233
176CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88340746
177MYC_22102868_ChIP-Seq_BL_Human0.87460815
178MAF_26560356_Chip-Seq_TH2_Human0.85658009
179GATA3_26560356_Chip-Seq_TH2_Human0.85080877
180STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84834112
181BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84291587
182FOXO3_23340844_ChIP-Seq_DLD1_Human0.84182880
183ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78855021
184ESR1_20079471_ChIP-ChIP_T-47D_Human0.78567688
185VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78418660
186GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77339247
187TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75756482
188* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74918153
189RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73981121
190STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73623245
191SOX9_24532713_ChIP-Seq_HFSC_Mouse0.73370993
192TBX20_22080862_ChIP-Seq_HEART_Mouse0.72681971
193TBX20_22328084_ChIP-Seq_HEART_Mouse0.72681971
194CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72169136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.34322003
2MP0004859_abnormal_synaptic_plasticity4.64200568
3MP0003635_abnormal_synaptic_transmissio3.52255920
4MP0003436_decreased_susceptibility_to3.47860056
5MP0009046_muscle_twitch3.34052312
6MP0001968_abnormal_touch/_nociception3.32198384
7MP0001835_abnormal_antigen_presentation3.23656469
8MP0009745_abnormal_behavioral_response3.22194765
9MP0001188_hyperpigmentation3.16759051
10MP0003136_yellow_coat_color3.06831601
11MP0002064_seizures2.96368657
12MP0005409_darkened_coat_color2.95940577
13MP0004270_analgesia2.83685213
14MP0006082_CNS_inflammation2.81635694
15MP0002419_abnormal_innate_immunity2.81630582
16MP0003300_gastrointestinal_ulcer2.80924508
17MP0003690_abnormal_glial_cell2.64055198
18MP0002272_abnormal_nervous_system2.60760743
19MP0001486_abnormal_startle_reflex2.60661183
20MP0002063_abnormal_learning/memory/cond2.56543926
21MP0003191_abnormal_cellular_cholesterol2.55795774
22MP0009785_altered_susceptibility_to2.49319247
23MP0002572_abnormal_emotion/affect_behav2.40146763
24MP0005000_abnormal_immune_tolerance2.39680879
25MP0002735_abnormal_chemical_nociception2.38653450
26MP0002734_abnormal_mechanical_nocicepti2.38544998
27MP0005025_abnormal_response_to2.36670194
28MP0000569_abnormal_digit_pigmentation2.34588497
29MP0002736_abnormal_nociception_after2.31184945
30MP0003172_abnormal_lysosome_physiology2.29829776
31MP0005423_abnormal_somatic_nervous2.27836688
32MP0002148_abnormal_hypersensitivity_rea2.27692873
33MP0001800_abnormal_humoral_immune2.23286915
34MP0005671_abnormal_response_to2.21739030
35MP0009379_abnormal_foot_pigmentation2.16197477
36MP0002067_abnormal_sensory_capabilities2.12328463
37MP0005387_immune_system_phenotype2.11502884
38MP0001790_abnormal_immune_system2.11502884
39MP0008260_abnormal_autophagy2.10562092
40MP0002452_abnormal_antigen_presenting2.10033262
41MP0002723_abnormal_immune_serum2.09546684
42MP0003828_pulmonary_edema2.09025524
43MP0000685_abnormal_immune_system2.07564257
44MP0001533_abnormal_skeleton_physiology2.07166986
45MP0001970_abnormal_pain_threshold2.06150588
46MP0006276_abnormal_autonomic_nervous2.05817101
47MP0001501_abnormal_sleep_pattern2.05813962
48MP0005058_abnormal_lysosome_morphology1.97453135
49MP0002733_abnormal_thermal_nociception1.95755658
50MP0002420_abnormal_adaptive_immunity1.93408457
51MP0001819_abnormal_immune_cell1.91993846
52MP0001440_abnormal_grooming_behavior1.87944573
53MP0005451_abnormal_body_composition1.86055048
54MP0005464_abnormal_platelet_physiology1.81038680
55MP0004947_skin_inflammation1.79491769
56MP0008569_lethality_at_weaning1.78583805
57MP0004381_abnormal_hair_follicle1.77553530
58MP0000604_amyloidosis1.72196296
59MP0004142_abnormal_muscle_tone1.71014213
60MP0009764_decreased_sensitivity_to1.69393478
61MP0005174_abnormal_tail_pigmentation1.68834756
62MP0009278_abnormal_bone_marrow1.63132191
63MP0004742_abnormal_vestibular_system1.58277574
64MP0002998_abnormal_bone_remodeling1.55397941
65MP0002184_abnormal_innervation1.54798956
66MP0002557_abnormal_social/conspecific_i1.54368653
67MP0002405_respiratory_system_inflammati1.53846386
68MP0000015_abnormal_ear_pigmentation1.51465037
69MP0003091_abnormal_cell_migration1.51188614
70MP0005164_abnormal_response_to1.47159438
71MP0005166_decreased_susceptibility_to1.46839450
72MP0000858_altered_metastatic_potential1.46742441
73MP0001845_abnormal_inflammatory_respons1.44806421
74MP0001905_abnormal_dopamine_level1.41693936
75MP0000343_altered_response_to1.39361371
76MP0002876_abnormal_thyroid_physiology1.39259411
77MP0000716_abnormal_immune_system1.39149529
78MP0000778_abnormal_nervous_system1.38050733
79MP0001986_abnormal_taste_sensitivity1.37529229
80MP0002332_abnormal_exercise_endurance1.37109449
81MP0001545_abnormal_hematopoietic_system1.36271864
82MP0005397_hematopoietic_system_phenotyp1.36271864
83MP0003448_altered_tumor_morphology1.35773720
84MP0003763_abnormal_thymus_physiology1.35770523
85MP0008004_abnormal_stomach_pH1.35051533
86MP0003183_abnormal_peptide_metabolism1.35036112
87MP0002822_catalepsy1.34323561
88MP0002398_abnormal_bone_marrow1.32599040
89MP0005167_abnormal_blood-brain_barrier1.32461677
90MP0004924_abnormal_behavior1.29590221
91MP0005386_behavior/neurological_phenoty1.29590221
92MP0003879_abnormal_hair_cell1.27714706
93MP0002877_abnormal_melanocyte_morpholog1.27106518
94MP0001851_eye_inflammation1.26052156
95MP0010155_abnormal_intestine_physiology1.25836622
96MP0000465_gastrointestinal_hemorrhage1.25213101
97MP0002102_abnormal_ear_morphology1.22385123
98MP0001853_heart_inflammation1.21867566
99MP0004130_abnormal_muscle_cell1.21445426
100MP0006292_abnormal_olfactory_placode1.20086540
101MP0000920_abnormal_myelination1.18523331
102MP0003656_abnormal_erythrocyte_physiolo1.18229579
103MP0002066_abnormal_motor_capabilities/c1.18125923
104MP0001984_abnormal_olfaction1.16024697
105MP0008469_abnormal_protein_level1.14385158
106MP0002882_abnormal_neuron_morphology1.13607454
107MP0005645_abnormal_hypothalamus_physiol1.12409737
108MP0004811_abnormal_neuron_physiology1.10927634
109MP0003329_amyloid_beta_deposits1.08280355
110MP0001348_abnormal_lacrimal_gland1.07198296
111MP0003633_abnormal_nervous_system1.07088348
112MP0003705_abnormal_hypodermis_morpholog1.06992087
113MP0004510_myositis1.06952904
114MP0008874_decreased_physiological_sensi1.06877877
115MP0003453_abnormal_keratinocyte_physiol1.06834678
116MP0005551_abnormal_eye_electrophysiolog1.05646754
117MP0001529_abnormal_vocalization1.03980187
118MP0002722_abnormal_immune_system1.03203948
119MP0001958_emphysema1.03167901
120MP0003303_peritoneal_inflammation1.02090035
121MP0000689_abnormal_spleen_morphology1.01817343
122MP0001502_abnormal_circadian_rhythm1.01476720
123MP0003866_abnormal_defecation1.01198587
124MP0000955_abnormal_spinal_cord1.01085011
125MP0002429_abnormal_blood_cell1.00992071
126MP0002254_reproductive_system_inflammat1.00156082
127MP0005646_abnormal_pituitary_gland0.99925362
128MP0001963_abnormal_hearing_physiology0.98905366
129MP0004484_altered_response_of0.96211873
130MP0003045_fibrosis0.94211158
131MP0002229_neurodegeneration0.93306420
132MP0002277_abnormal_respiratory_mucosa0.93266087
133MP0004885_abnormal_endolymph0.91561365
134MP0005310_abnormal_salivary_gland0.89807981
135MP0008872_abnormal_physiological_respon0.89664020
136MP0002166_altered_tumor_susceptibility0.88797887
137MP0002095_abnormal_skin_pigmentation0.86320991
138MP0003631_nervous_system_phenotype0.85875611
139MP0002638_abnormal_pupillary_reflex0.85754593
140MP0004808_abnormal_hematopoietic_stem0.85415858
141MP0005379_endocrine/exocrine_gland_phen0.84637861
142MP0004145_abnormal_muscle_electrophysio0.81724426
143MP0005390_skeleton_phenotype0.80412039
144MP0000249_abnormal_blood_vessel0.80200295
145MP0005535_abnormal_body_temperature0.79244355
146MP0009333_abnormal_splenocyte_physiolog0.79161351
147MP0001346_abnormal_lacrimal_gland0.79005251
148MP0003566_abnormal_cell_adhesion0.78572694
149MP0005388_respiratory_system_phenotype0.78326814
150MP0002133_abnormal_respiratory_system0.78326814
151MP0002163_abnormal_gland_morphology0.78281866
152MP0003787_abnormal_imprinting0.77433433
153MP0000703_abnormal_thymus_morphology0.76876393
154MP0002752_abnormal_somatic_nervous0.76636256
155MP0002152_abnormal_brain_morphology0.75494061
156MP0003724_increased_susceptibility_to0.74306182
157MP0003221_abnormal_cardiomyocyte_apopto0.74004187
158MP0005595_abnormal_vascular_smooth0.73932770
159MP0006054_spinal_hemorrhage0.73351458
160MP0005076_abnormal_cell_differentiation0.73147345
161MP0002006_tumorigenesis0.72767372
162MP0002132_abnormal_respiratory_system0.72750682
163MP0000026_abnormal_inner_ear0.72566859
164MP0001664_abnormal_digestion0.71897002
165MP0009763_increased_sensitivity_to0.71631892
166MP0001485_abnormal_pinna_reflex0.70892822
167MP0001177_atelectasis0.70257718
168MP0009840_abnormal_foam_cell0.69649153
169MP0002009_preneoplasia0.68553360
170MP0010352_gastrointestinal_tract_polyps0.68488991
171MP0002396_abnormal_hematopoietic_system0.68440942
172MP0005171_absent_coat_pigmentation0.67908627
173MP0010386_abnormal_urinary_bladder0.67452322
174MP0003938_abnormal_ear_development0.64564330
175MP0002909_abnormal_adrenal_gland0.61836785
176MP0002069_abnormal_eating/drinking_beha0.60716916
177MP0004147_increased_porphyrin_level0.59222739
178MP0000631_abnormal_neuroendocrine_gland0.58375987
179MP0003632_abnormal_nervous_system0.56310585
180MP0004883_abnormal_blood_vessel0.56255890
181MP0002138_abnormal_hepatobiliary_system0.56085120
182MP0003075_altered_response_to0.53727830
183MP0004858_abnormal_nervous_system0.53506408
184MP0003634_abnormal_glial_cell0.52928680

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.65370005
2Eczematoid dermatitis (HP:0000976)5.43308331
3Recurrent bacterial skin infections (HP:0005406)5.38046966
4Focal seizures (HP:0007359)5.09541293
5Febrile seizures (HP:0002373)5.05596652
6Recurrent abscess formation (HP:0002722)5.05156797
7Atonic seizures (HP:0010819)4.86415955
8Orchitis (HP:0100796)4.85807189
9Myokymia (HP:0002411)4.73953920
10Optic neuritis (HP:0100653)4.71835221
11Retrobulbar optic neuritis (HP:0100654)4.71835221
12Myositis (HP:0100614)4.65836332
13Abnormality of macrophages (HP:0004311)4.41674180
14Epileptic encephalopathy (HP:0200134)4.35060644
15Visual hallucinations (HP:0002367)4.24161579
16Progressive cerebellar ataxia (HP:0002073)4.07819883
17Absence seizures (HP:0002121)3.95991083
18Recurrent gram-negative bacterial infections (HP:0005420)3.90099126
19Dialeptic seizures (HP:0011146)3.81692105
20Gaze-evoked nystagmus (HP:0000640)3.70384749
21Broad-based gait (HP:0002136)3.69083523
22Hyperventilation (HP:0002883)3.63701566
23Abnormality of the axillary hair (HP:0100134)3.59523772
24Abnormality of secondary sexual hair (HP:0009888)3.59523772
25Progressive inability to walk (HP:0002505)3.51129938
26Keratoconjunctivitis sicca (HP:0001097)3.49650856
27Generalized tonic-clonic seizures (HP:0002069)3.47386501
28Mediastinal lymphadenopathy (HP:0100721)3.47276117
29Stomatitis (HP:0010280)3.43092457
30Abnormality of glycolipid metabolism (HP:0010969)3.42656140
31Abnormality of liposaccharide metabolism (HP:0010968)3.42656140
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.42656140
33Recurrent skin infections (HP:0001581)3.36712388
34Gingivitis (HP:0000230)3.30921649
35Recurrent fungal infections (HP:0002841)3.23696821
36Absent speech (HP:0001344)3.22235557
37Gastrointestinal infarctions (HP:0005244)3.21058570
38Amyloidosis (HP:0011034)3.18284648
39Spontaneous hematomas (HP:0007420)3.17788333
40Keratoconjunctivitis (HP:0001096)3.14529802
41T lymphocytopenia (HP:0005403)3.10183086
42Action tremor (HP:0002345)3.08687838
43Obstructive sleep apnea (HP:0002870)3.06221811
44Elevated erythrocyte sedimentation rate (HP:0003565)2.94359573
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.92066853
46Absent/shortened dynein arms (HP:0200106)2.92066853
47Abnormal sex determination (HP:0012244)2.90146142
48Sex reversal (HP:0012245)2.90146142
49Dysmetria (HP:0001310)2.90095834
50Scanning speech (HP:0002168)2.84537492
51Abnormality of T cell number (HP:0011839)2.82198276
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.81689565
53Meningitis (HP:0001287)2.78563411
54Increased cerebral lipofuscin (HP:0011813)2.78157380
55Peritonitis (HP:0002586)2.77223569
56Inability to walk (HP:0002540)2.74979306
57Chronic mucocutaneous candidiasis (HP:0002728)2.74836455
58Arterial thrombosis (HP:0004420)2.73638435
59Dysdiadochokinesis (HP:0002075)2.72489129
60Cellulitis (HP:0100658)2.71733925
61Hemoptysis (HP:0002105)2.63960775
62Vasculitis (HP:0002633)2.61221249
63Pulmonary infiltrates (HP:0002113)2.60752432
64Disinhibition (HP:0000734)2.58899718
65Amblyopia (HP:0000646)2.55975665
66Truncal ataxia (HP:0002078)2.55781211
67Loss of speech (HP:0002371)2.52786901
68Poor eye contact (HP:0000817)2.49492871
69Gingival bleeding (HP:0000225)2.49484922
70Supranuclear gaze palsy (HP:0000605)2.49266055
71Urticaria (HP:0001025)2.48273723
72Chest pain (HP:0100749)2.48122154
73Hemiparesis (HP:0001269)2.47465222
74Encephalitis (HP:0002383)2.45786545
75Abnormal ciliary motility (HP:0012262)2.45362703
76Dysostosis multiplex (HP:0000943)2.41741518
77Episodic fever (HP:0001954)2.39467568
78Excessive salivation (HP:0003781)2.38923296
79Drooling (HP:0002307)2.38923296
80Diplopia (HP:0000651)2.37660424
81Abnormality of binocular vision (HP:0011514)2.37660424
82Slow saccadic eye movements (HP:0000514)2.37186339
83Increased IgE level (HP:0003212)2.36099103
84Mutism (HP:0002300)2.35185569
85Fair hair (HP:0002286)2.31166568
86Esotropia (HP:0000565)2.30229298
87Generalized myoclonic seizures (HP:0002123)2.29824544
88Agammaglobulinemia (HP:0004432)2.29122124
89Recurrent viral infections (HP:0004429)2.27878026
90Pulmonary embolism (HP:0002204)2.27650309
91Subacute progressive viral hepatitis (HP:0006572)2.26870588
92Anxiety (HP:0000739)2.26018017
93Peripheral hypomyelination (HP:0007182)2.24461811
94Impaired social interactions (HP:0000735)2.23945774
95Abnormal social behavior (HP:0012433)2.23945774
96Sleep apnea (HP:0010535)2.23803372
97Genetic anticipation (HP:0003743)2.20116735
98Vertigo (HP:0002321)2.18155597
99Epistaxis (HP:0000421)2.18145446
100Leukocytosis (HP:0001974)2.17536269
101Optic disc pallor (HP:0000543)2.16902718
102Gangrene (HP:0100758)2.15473642
103Interstitial pulmonary disease (HP:0006530)2.14974883
104Generalized hypopigmentation of hair (HP:0011358)2.14801282
105Neurofibrillary tangles (HP:0002185)2.14701896
106Neuronal loss in central nervous system (HP:0002529)2.13048087
107Nonprogressive disorder (HP:0003680)2.12101896
108Papilledema (HP:0001085)2.12065888
109Prolonged bleeding time (HP:0003010)2.11709772
110Abnormal eating behavior (HP:0100738)2.11214168
111Abnormal delayed hypersensitivity skin test (HP:0002963)2.11057422
112Hemiplegia (HP:0002301)2.10592675
113Osteomyelitis (HP:0002754)2.09735130
114Abnormality of the endocardium (HP:0004306)2.09292500
115Retinal dysplasia (HP:0007973)2.08856716
116Depression (HP:0000716)2.08850231
117Postural instability (HP:0002172)2.07802967
118Status epilepticus (HP:0002133)2.07350321
119Increased neuronal autofluorescent lipopigment (HP:0002074)2.04611410
120Bile duct proliferation (HP:0001408)2.03054813
121Abnormal biliary tract physiology (HP:0012439)2.03054813
122Iris hypopigmentation (HP:0007730)2.03048584
123Myocardial infarction (HP:0001658)2.02102746
124Split foot (HP:0001839)1.99472020
125Stereotypic behavior (HP:0000733)1.98771630
126Abnormal respiratory motile cilium physiology (HP:0012261)1.97089363
127Blue irides (HP:0000635)1.95236427
128Abnormal respiratory motile cilium morphology (HP:0005938)1.92891038
129Abnormal respiratory epithelium morphology (HP:0012253)1.92891038
130Anorexia (HP:0002039)1.92607964
131Protruding tongue (HP:0010808)1.91963712
132Systemic lupus erythematosus (HP:0002725)1.91058137
133Urinary bladder sphincter dysfunction (HP:0002839)1.90117214
134Apathy (HP:0000741)1.89186222
135Ocular albinism (HP:0001107)1.89124492
136Abnormality of salivation (HP:0100755)1.88159129
137Thickened helices (HP:0000391)1.87830093
138Abnormality of the peritoneum (HP:0002585)1.87581611
139Thyroid-stimulating hormone excess (HP:0002925)1.87156532
140Glomerulopathy (HP:0100820)1.86981824
141Autoimmune thrombocytopenia (HP:0001973)1.86933688
142Inflammation of the large intestine (HP:0002037)1.86519814
143Impaired smooth pursuit (HP:0007772)1.84617431
144Urinary glycosaminoglycan excretion (HP:0003541)1.84369322
145Mucopolysacchariduria (HP:0008155)1.84369322
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84286125
147Abnormality of polysaccharide metabolism (HP:0011012)1.84286125
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84286125
149Sepsis (HP:0100806)1.83838045
150Cerebral inclusion bodies (HP:0100314)1.83450401
151Increased CSF protein (HP:0002922)1.83301677
152Abnormality of the pleura (HP:0002103)1.83142413
153Viral hepatitis (HP:0006562)1.82644453
154Segmental peripheral demyelination/remyelination (HP:0003481)1.81395592
155Ulnar claw (HP:0001178)1.81327850
156Colitis (HP:0002583)1.81216630
157Obstructive lung disease (HP:0006536)1.80745331
158Chronic obstructive pulmonary disease (HP:0006510)1.80745331
159Hyperthyroidism (HP:0000836)1.80615685
160Diminished motivation (HP:0000745)1.80033992
161Difficulty running (HP:0009046)1.79100513
162Attenuation of retinal blood vessels (HP:0007843)1.78832874
163Hypothermia (HP:0002045)1.78647703
164Limb dystonia (HP:0002451)1.77869854
165Impaired vibration sensation in the lower limbs (HP:0002166)1.77867203
166Psychosis (HP:0000709)1.77501633
167Sensory axonal neuropathy (HP:0003390)1.77121130
168Hematochezia (HP:0002573)1.75590807
169Gastrointestinal inflammation (HP:0004386)1.75578115
170Alacrima (HP:0000522)1.75460775
171Fetal akinesia sequence (HP:0001989)1.75226468
172Periodontitis (HP:0000704)1.75045309
173Memory impairment (HP:0002354)1.74023780
174Widely spaced teeth (HP:0000687)1.73190827
175Testicular neoplasm (HP:0010788)1.72587602
176Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71839323
177Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70524742
178Rapidly progressive (HP:0003678)1.69388215
179Vacuolated lymphocytes (HP:0001922)1.68980957
180Optic nerve hypoplasia (HP:0000609)1.67646206
181Parakeratosis (HP:0001036)1.66868770
182Polyphagia (HP:0002591)1.66408144
183Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65726114
184Clumsiness (HP:0002312)1.64542443
185Intention tremor (HP:0002080)1.63503258
186Horizontal nystagmus (HP:0000666)1.60528936
187Inappropriate behavior (HP:0000719)1.59996886
188Recurrent cutaneous fungal infections (HP:0011370)1.59807012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.11416989
2NTRK33.54503845
3RIPK43.09841640
4TNIK3.04181575
5EPHA42.79839550
6MAP3K122.77072530
7MKNK22.65913317
8FES2.65528286
9MAP2K32.60967361
10TYK22.56331798
11MAP2K72.51056078
12CSK2.38244163
13CDK192.10990376
14PNCK1.93737335
15MAP3K91.90187073
16MAP3K41.88613032
17MAP3K131.87553162
18JAK11.82843367
19ZAP701.75610552
20MINK11.70953944
21JAK31.69184172
22ERN11.69129274
23RIPK11.67876563
24MAP2K41.66743979
25MAP4K11.63777370
26MAP3K31.61173834
27MUSK1.57907396
28EPHB11.57170805
29JAK21.55628332
30GRK51.51286248
31TGFBR21.49451518
32PHKG21.43955067
33PHKG11.43955067
34IKBKE1.43353231
35BMPR21.42314783
36IRAK31.34623637
37DAPK21.33524478
38BLK1.32767261
39HCK1.31467939
40FGR1.30107864
41MAP3K11.28246033
42SIK21.26914117
43TBK11.25383645
44MAPK131.23383579
45MOS1.23149147
46TAOK11.19864647
47CAMKK21.18692774
48BTK1.18472730
49SGK31.16837572
50OXSR11.16353599
51CDK51.10592515
52MAP3K111.08708701
53TXK1.08474851
54TLK11.07789074
55NTRK11.07197709
56ARAF1.05616232
57CAMK2A1.04759337
58CSF1R1.04463080
59CAMK2B1.03807635
60PRPF4B1.02847519
61MKNK11.02469832
62TAOK21.00716239
63MARK21.00095659
64LYN0.99159280
65GRK70.98922611
66PLK20.98312105
67NTRK20.98055107
68CAMK10.96690849
69TNK20.96339509
70PKN10.94185173
71DYRK1A0.93286637
72STK390.92269343
73KSR10.90351060
74STK110.89914907
75PAK60.88860161
76DAPK10.88677839
77TRIB30.88216703
78MARK10.87339189
79UHMK10.87115849
80MAPKAPK50.87068494
81FGFR30.85721488
82PIK3CG0.83378409
83LCK0.80193053
84STK380.77067733
85CAMKK10.76252864
86IRAK40.75064520
87MAP3K50.74599449
88NME10.74548092
89FER0.74354142
90WNK10.74244838
91ADRBK20.73811983
92INSRR0.72826748
93PDGFRB0.72344419
94RET0.71745773
95KSR20.70866256
96PRKCG0.70052538
97STK100.69214302
98CDK60.68677686
99MARK30.68574391
100CDC42BPA0.68491867
101PRKCE0.68084598
102MAP3K140.67688911
103PTK2B0.67503900
104MAPK70.65120474
105KIT0.64783090
106STK160.62463807
107IKBKB0.61612686
108CAMK2D0.61325848
109LRRK20.60862715
110NEK90.60785017
111MAP3K60.60516957
112SIK30.60181150
113ITK0.60172174
114IRAK20.59932578
115TEC0.57541132
116PRKD20.56624246
117SGK10.56497168
118SYK0.55126799
119RAF10.54047113
120IRAK10.53808667
121NEK60.53808186
122TTN0.53403267
123BMPR1B0.52672368
124CAMK2G0.50813488
125HIPK20.49922668
126CAMK1G0.49349271
127PTK60.47232530
128PRKG10.45857877
129YES10.45764007
130TAOK30.45634170
131CDK30.45359637
132TRPM70.45201925
133PRKCQ0.43636060
134SGK4940.42850558
135SGK2230.42850558
136ROCK20.42791649
137PRKAA20.41662998
138FYN0.41244758
139MATK0.40747449
140MAPK120.39653834
141GRK60.39495188
142PDK10.39387544
143DYRK1B0.38928849
144CLK10.38277340
145PDPK10.38173944
146SGK20.38148960
147MAP3K20.38112481
148CDK140.37824462
149CSNK1G20.37568820
150PRKACA0.36889880
151BCR0.36303806
152CAMK40.34049444
153RPS6KC10.33519510
154RPS6KL10.33519510

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26586795
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.93655218
3Glutamatergic synapse_Homo sapiens_hsa047242.70510732
4GABAergic synapse_Homo sapiens_hsa047272.66750831
5Morphine addiction_Homo sapiens_hsa050322.66087013
6Leishmaniasis_Homo sapiens_hsa051402.53877233
7Synaptic vesicle cycle_Homo sapiens_hsa047212.50373417
8Long-term potentiation_Homo sapiens_hsa047202.41044997
9Circadian entrainment_Homo sapiens_hsa047132.33534646
10Taste transduction_Homo sapiens_hsa047422.29089454
11Olfactory transduction_Homo sapiens_hsa047402.21185290
12Salivary secretion_Homo sapiens_hsa049702.19037691
13Long-term depression_Homo sapiens_hsa047302.17933281
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14700817
15Staphylococcus aureus infection_Homo sapiens_hsa051502.06604325
16Serotonergic synapse_Homo sapiens_hsa047262.06225286
17Amphetamine addiction_Homo sapiens_hsa050312.05413144
18Dopaminergic synapse_Homo sapiens_hsa047281.80156936
19Calcium signaling pathway_Homo sapiens_hsa040201.78792307
20Malaria_Homo sapiens_hsa051441.77304500
21Phototransduction_Homo sapiens_hsa047441.74431512
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74020232
23Renin secretion_Homo sapiens_hsa049241.72596966
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71919669
25Cholinergic synapse_Homo sapiens_hsa047251.65272313
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64733735
27Gastric acid secretion_Homo sapiens_hsa049711.64330969
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64240499
29Collecting duct acid secretion_Homo sapiens_hsa049661.55606221
30Legionellosis_Homo sapiens_hsa051341.54479559
31Oxytocin signaling pathway_Homo sapiens_hsa049211.47368195
32Toxoplasmosis_Homo sapiens_hsa051451.46506683
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45002893
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.43861214
35Insulin secretion_Homo sapiens_hsa049111.42135319
36TNF signaling pathway_Homo sapiens_hsa046681.41883659
37GnRH signaling pathway_Homo sapiens_hsa049121.38662783
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38252477
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36287645
40Graft-versus-host disease_Homo sapiens_hsa053321.36120311
41Measles_Homo sapiens_hsa051621.32586100
42Acute myeloid leukemia_Homo sapiens_hsa052211.31636668
43Influenza A_Homo sapiens_hsa051641.30639560
44Phagosome_Homo sapiens_hsa041451.28742178
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26603066
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26326029
47Pertussis_Homo sapiens_hsa051331.23554060
48Other glycan degradation_Homo sapiens_hsa005111.22643303
49Non-small cell lung cancer_Homo sapiens_hsa052231.22571410
50cAMP signaling pathway_Homo sapiens_hsa040241.21836742
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21404712
52Oxidative phosphorylation_Homo sapiens_hsa001901.20842686
53Cocaine addiction_Homo sapiens_hsa050301.20097372
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.18597028
55Salmonella infection_Homo sapiens_hsa051321.17861381
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15073636
57Lysosome_Homo sapiens_hsa041421.14781732
58Hematopoietic cell lineage_Homo sapiens_hsa046401.14325387
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11857864
60Alzheimers disease_Homo sapiens_hsa050101.10197608
61Hepatitis B_Homo sapiens_hsa051611.10014716
62Cardiac muscle contraction_Homo sapiens_hsa042601.09398946
63Chronic myeloid leukemia_Homo sapiens_hsa052201.08729503
64Renal cell carcinoma_Homo sapiens_hsa052111.07754658
65African trypanosomiasis_Homo sapiens_hsa051431.07328448
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06760719
67Leukocyte transendothelial migration_Homo sapiens_hsa046701.06737795
68Axon guidance_Homo sapiens_hsa043601.06692022
69Pancreatic cancer_Homo sapiens_hsa052121.05355897
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02097845
71Hepatitis C_Homo sapiens_hsa051600.99898431
72Melanogenesis_Homo sapiens_hsa049160.99604606
73Prolactin signaling pathway_Homo sapiens_hsa049170.99588956
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99291775
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99214766
76Amoebiasis_Homo sapiens_hsa051460.98989209
77Gap junction_Homo sapiens_hsa045400.98030274
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97362582
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96957220
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93293556
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91488916
82Viral myocarditis_Homo sapiens_hsa054160.89169186
83Antigen processing and presentation_Homo sapiens_hsa046120.88350088
84Apoptosis_Homo sapiens_hsa042100.87970209
85ErbB signaling pathway_Homo sapiens_hsa040120.87665641
86Pancreatic secretion_Homo sapiens_hsa049720.87544676
87Type I diabetes mellitus_Homo sapiens_hsa049400.84660617
88Estrogen signaling pathway_Homo sapiens_hsa049150.84257581
89Shigellosis_Homo sapiens_hsa051310.82898638
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82527439
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.82391253
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.82257460
93Dorso-ventral axis formation_Homo sapiens_hsa043200.80527187
94MAPK signaling pathway_Homo sapiens_hsa040100.80320535
95Endometrial cancer_Homo sapiens_hsa052130.79461183
96Herpes simplex infection_Homo sapiens_hsa051680.78076554
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76838815
98FoxO signaling pathway_Homo sapiens_hsa040680.76755895
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.76400998
100Endocytosis_Homo sapiens_hsa041440.75920014
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75633745
102mTOR signaling pathway_Homo sapiens_hsa041500.75067732
103Vibrio cholerae infection_Homo sapiens_hsa051100.74811513
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.74137566
105Choline metabolism in cancer_Homo sapiens_hsa052310.72609629
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72143122
107Parkinsons disease_Homo sapiens_hsa050120.71962765
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.70371713
109Rheumatoid arthritis_Homo sapiens_hsa053230.70192947
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67837390
111Type II diabetes mellitus_Homo sapiens_hsa049300.67226009
112Ras signaling pathway_Homo sapiens_hsa040140.67037890
113Chemokine signaling pathway_Homo sapiens_hsa040620.66672468
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65518193
115Ether lipid metabolism_Homo sapiens_hsa005650.65469119
116HIF-1 signaling pathway_Homo sapiens_hsa040660.64886787
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63411311
118Glioma_Homo sapiens_hsa052140.63375591
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62954564
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.60063769
121Prion diseases_Homo sapiens_hsa050200.59814600
122Notch signaling pathway_Homo sapiens_hsa043300.58421236
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57619034
124Primary immunodeficiency_Homo sapiens_hsa053400.57331095
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54279388
126Proteoglycans in cancer_Homo sapiens_hsa052050.52852463
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51473001
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50385883
129Inositol phosphate metabolism_Homo sapiens_hsa005620.49918084
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48628668
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46597576
132Thyroid hormone synthesis_Homo sapiens_hsa049180.45524314
133VEGF signaling pathway_Homo sapiens_hsa043700.43768965
134B cell receptor signaling pathway_Homo sapiens_hsa046620.43539624
135Huntingtons disease_Homo sapiens_hsa050160.43228434
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40949771
137Sphingolipid metabolism_Homo sapiens_hsa006000.40821523
138Allograft rejection_Homo sapiens_hsa053300.40250173
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40126677
140Osteoclast differentiation_Homo sapiens_hsa043800.40054089
141Rap1 signaling pathway_Homo sapiens_hsa040150.39987814
142Asthma_Homo sapiens_hsa053100.39587399
143Platelet activation_Homo sapiens_hsa046110.38240401
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.37379251
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36121694
146Autoimmune thyroid disease_Homo sapiens_hsa053200.34267547
147Ovarian steroidogenesis_Homo sapiens_hsa049130.33819912
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33554240
149Wnt signaling pathway_Homo sapiens_hsa043100.33314025
150Circadian rhythm_Homo sapiens_hsa047100.33007271
151Tuberculosis_Homo sapiens_hsa051520.31728223
152Alcoholism_Homo sapiens_hsa050340.30812484
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29226222
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28825636
155Glucagon signaling pathway_Homo sapiens_hsa049220.27524204
156T cell receptor signaling pathway_Homo sapiens_hsa046600.25830774

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