OFCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primary amino compound metabolic process (GO:1901160)9.87789912
2brain morphogenesis (GO:0048854)9.86262397
3fatty acid elongation (GO:0030497)9.30919084
4long-chain fatty acid biosynthetic process (GO:0042759)8.89668788
5dopamine biosynthetic process (GO:0042416)8.40810116
6regulation of synaptic transmission, dopaminergic (GO:0032225)8.36059608
7toxin metabolic process (GO:0009404)8.29773783
8negative regulation of neural precursor cell proliferation (GO:2000178)7.12018259
9monoamine transport (GO:0015844)7.00290164
10indolalkylamine metabolic process (GO:0006586)6.45927551
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.06376196
12negative regulation of organ growth (GO:0046621)5.96407411
13vasoconstriction (GO:0042310)5.53371892
14fatty-acyl-CoA biosynthetic process (GO:0046949)5.49001408
15cellular biogenic amine biosynthetic process (GO:0042401)5.32180442
16amine biosynthetic process (GO:0009309)5.32180442
17multicellular organismal aging (GO:0010259)5.30424424
18catecholamine biosynthetic process (GO:0042423)5.19417699
19catechol-containing compound biosynthetic process (GO:0009713)5.19417699
20long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.13811411
21indole-containing compound metabolic process (GO:0042430)5.12601479
22piRNA metabolic process (GO:0034587)4.97072260
23DNA methylation involved in gamete generation (GO:0043046)4.83544893
24intraspecies interaction between organisms (GO:0051703)4.63017423
25social behavior (GO:0035176)4.63017423
26tachykinin receptor signaling pathway (GO:0007217)4.55882790
27cilium or flagellum-dependent cell motility (GO:0001539)4.49571739
28fatty-acyl-CoA metabolic process (GO:0035337)4.48289313
29protein polyglutamylation (GO:0018095)4.35778179
30acyl-CoA biosynthetic process (GO:0071616)4.35739388
31thioester biosynthetic process (GO:0035384)4.35739388
32multicellular organism reproduction (GO:0032504)4.35379064
33regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.34196931
34oxygen transport (GO:0015671)4.29329738
35tryptophan catabolic process (GO:0006569)4.22312522
36indole-containing compound catabolic process (GO:0042436)4.22312522
37indolalkylamine catabolic process (GO:0046218)4.22312522
38neuromuscular process controlling posture (GO:0050884)4.13319576
39phenol-containing compound biosynthetic process (GO:0046189)4.00397718
40negative regulation of synaptic transmission (GO:0050805)3.99834996
41photoreceptor cell maintenance (GO:0045494)3.96234571
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.90722175
43peptidyl-arginine omega-N-methylation (GO:0035247)3.81729800
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.80983424
45acrosome reaction (GO:0007340)3.76543699
46regulation of meiosis I (GO:0060631)3.71448291
47male meiosis (GO:0007140)3.64591207
48cellular ketone body metabolic process (GO:0046950)3.62963418
49centriole replication (GO:0007099)3.62785358
50regulation of neurotransmitter levels (GO:0001505)3.56328523
51neurotransmitter transport (GO:0006836)3.55639810
52sperm motility (GO:0030317)3.54597022
53regulation of cilium movement (GO:0003352)3.54053241
54response to pheromone (GO:0019236)3.51771422
55tryptophan metabolic process (GO:0006568)3.49654477
56NAD biosynthetic process (GO:0009435)3.48969621
57layer formation in cerebral cortex (GO:0021819)3.43829733
58protein localization to cilium (GO:0061512)3.38882054
59axoneme assembly (GO:0035082)3.37836808
60positive regulation of gastrulation (GO:2000543)3.36908644
61ketone body metabolic process (GO:1902224)3.35666506
62male meiosis I (GO:0007141)3.35190585
63epithelial cilium movement (GO:0003351)3.32520685
64platelet dense granule organization (GO:0060155)3.30265821
65cholesterol biosynthetic process (GO:0006695)3.28359536
66reflex (GO:0060004)3.26257239
67dopamine metabolic process (GO:0042417)3.25002720
68regulation of acrosome reaction (GO:0060046)3.22279761
69heart valve formation (GO:0003188)3.21214370
70kynurenine metabolic process (GO:0070189)3.19790491
71establishment of protein localization to Golgi (GO:0072600)3.19313510
72cellular biogenic amine catabolic process (GO:0042402)3.18828715
73amine catabolic process (GO:0009310)3.18828715
74cilium organization (GO:0044782)3.18162802
75regulation of synaptic vesicle transport (GO:1902803)3.14829628
76opioid receptor signaling pathway (GO:0038003)3.14595494
77cilium morphogenesis (GO:0060271)3.14468518
78negative regulation of telomere maintenance (GO:0032205)3.12552679
79cilium assembly (GO:0042384)3.12490518
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11966115
81regulation of synaptic vesicle exocytosis (GO:2000300)3.10251426
82peptidyl-arginine N-methylation (GO:0035246)3.09767966
83peptidyl-arginine methylation (GO:0018216)3.09767966
84nonmotile primary cilium assembly (GO:0035058)3.06971755
85sperm-egg recognition (GO:0035036)3.06722096
86interkinetic nuclear migration (GO:0022027)3.04763334
87cilium movement (GO:0003341)3.04746617
88detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.04674818
89detection of temperature stimulus involved in sensory perception (GO:0050961)3.04674818
90reciprocal meiotic recombination (GO:0007131)3.04625199
91reciprocal DNA recombination (GO:0035825)3.04625199
92regulation of transmission of nerve impulse (GO:0051969)3.04468745
93secondary metabolic process (GO:0019748)3.03055339
94protein K11-linked deubiquitination (GO:0035871)3.00474185
95oocyte development (GO:0048599)2.97893957
96peptidyl-arginine modification (GO:0018195)2.94348105
97retinal cone cell development (GO:0046549)2.92752886
98very long-chain fatty acid metabolic process (GO:0000038)2.92467561
99centriole assembly (GO:0098534)2.91762297
100synaptic vesicle maturation (GO:0016188)2.90877584
101synapsis (GO:0007129)2.90540126
102regulation of rhodopsin mediated signaling pathway (GO:0022400)2.90143796
103gamma-aminobutyric acid transport (GO:0015812)2.88735398
104GTP biosynthetic process (GO:0006183)2.88547020
105regulation of female gonad development (GO:2000194)2.88315093
106benzene-containing compound metabolic process (GO:0042537)2.87427416
107sterol biosynthetic process (GO:0016126)2.86068939
108DNA integration (GO:0015074)2.85884644
109activation of protein kinase A activity (GO:0034199)2.85822480
110synaptic vesicle exocytosis (GO:0016079)2.85439782
111rhodopsin mediated signaling pathway (GO:0016056)2.85422520
112detection of mechanical stimulus involved in sensory perception (GO:0050974)2.83275860
113proline transport (GO:0015824)2.82843620
114aromatic amino acid family catabolic process (GO:0009074)2.82369042
115keratinocyte proliferation (GO:0043616)2.78214071
116regulation of telomere maintenance (GO:0032204)2.77755557
117reproduction (GO:0000003)2.76890469
118righting reflex (GO:0060013)2.75753674
119retinal metabolic process (GO:0042574)2.75663460
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74868722
121protein targeting to Golgi (GO:0000042)2.73178401
122DNA double-strand break processing (GO:0000729)2.73081828
123positive regulation of digestive system process (GO:0060456)2.72059066
124replication fork processing (GO:0031297)2.71865969
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71730883
126positive regulation of uterine smooth muscle contraction (GO:0070474)2.69804419
127negative regulation of calcium ion transport into cytosol (GO:0010523)2.67972027
128sulfation (GO:0051923)2.67909590
129UTP biosynthetic process (GO:0006228)2.67705111
130sensory perception of smell (GO:0007608)2.66350733
131neuronal action potential (GO:0019228)2.66317261
132behavioral response to nicotine (GO:0035095)2.65673993
133synaptic vesicle transport (GO:0048489)2.65146682
134establishment of synaptic vesicle localization (GO:0097480)2.65146682
135meiosis I (GO:0007127)2.64729221
136regulation of cAMP-dependent protein kinase activity (GO:2000479)2.63177703
137aggressive behavior (GO:0002118)2.62738259
138retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62236086
139triglyceride biosynthetic process (GO:0019432)2.61725400
140neural tube formation (GO:0001841)2.60416613
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59515983
142pyrimidine dimer repair (GO:0006290)2.59074180
143cell-cell recognition (GO:0009988)2.58918461
144nicotinamide nucleotide biosynthetic process (GO:0019359)2.57749407
145pyridine nucleotide biosynthetic process (GO:0019363)2.57749407
146UTP metabolic process (GO:0046051)2.57020093
147xenobiotic catabolic process (GO:0042178)2.56372997
148phosphatidylinositol acyl-chain remodeling (GO:0036149)2.56217243
149negative regulation of glycogen metabolic process (GO:0070874)2.55493493
150CTP biosynthetic process (GO:0006241)2.55015187
151CTP metabolic process (GO:0046036)2.55015187
152neuron cell-cell adhesion (GO:0007158)2.54922758
153response to methylmercury (GO:0051597)2.53949741
154oxidative demethylation (GO:0070989)2.53949114
155pyrimidine nucleotide catabolic process (GO:0006244)2.53633928
156neuronal action potential propagation (GO:0019227)2.53483739
157intraciliary transport (GO:0042073)2.53020258
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52991519
159photoreceptor cell development (GO:0042461)2.52319406
160regulation of hippo signaling (GO:0035330)2.52176889
161neutral lipid biosynthetic process (GO:0046460)2.51272767
162acylglycerol biosynthetic process (GO:0046463)2.51272767
163regulation of glutamate secretion (GO:0014048)2.51184160
164multi-organism behavior (GO:0051705)2.51090229
165spermatid development (GO:0007286)2.50389372
166positive regulation of protein homodimerization activity (GO:0090073)2.49905618
167neurotransmitter secretion (GO:0007269)2.49670138
168startle response (GO:0001964)2.49420185
169regulation of blood vessel size (GO:0050880)2.48586080
170S-adenosylmethionine metabolic process (GO:0046500)2.47587502
171single fertilization (GO:0007338)2.47263381
172adaptation of signaling pathway (GO:0023058)2.46497720
173histone arginine methylation (GO:0034969)2.44955888
174regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.44937790
175detection of light stimulus involved in visual perception (GO:0050908)2.44872452
176detection of light stimulus involved in sensory perception (GO:0050962)2.44872452
177regulation of tube size (GO:0035150)2.44142704
178negative regulation of synaptic transmission, GABAergic (GO:0032229)2.42611655
179pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.41966576
180gamma-aminobutyric acid signaling pathway (GO:0007214)2.39910202
181neuron recognition (GO:0008038)2.39670785
182cellular response to drug (GO:0035690)2.38961839
183cellular response to alkaloid (GO:0071312)2.36821808
184cellular response to retinoic acid (GO:0071300)2.35907725
185pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.35561471
186left/right pattern formation (GO:0060972)2.35276460
187regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31910216
188relaxation of smooth muscle (GO:0044557)2.30281684
189glutamate secretion (GO:0014047)2.29483132
190alkaloid metabolic process (GO:0009820)14.5825261
191serotonin metabolic process (GO:0042428)11.8522165
192thalamus development (GO:0021794)11.6080195
193neurotransmitter uptake (GO:0001504)10.9796845
194response to insecticide (GO:0017085)10.1650898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.58244753
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.34469499
3GATA1_22025678_ChIP-Seq_K562_Human3.19807378
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77486593
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68256698
6ZNF274_21170338_ChIP-Seq_K562_Hela2.63919604
7IGF1R_20145208_ChIP-Seq_DFB_Human2.52385505
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48309725
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47437672
10* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47357109
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40588142
12EZH2_22144423_ChIP-Seq_EOC_Human2.40144140
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33559212
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28956757
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28956757
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26266349
17FUS_26573619_Chip-Seq_HEK293_Human2.18999432
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18404273
19VDR_22108803_ChIP-Seq_LS180_Human2.15071167
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12416768
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06597188
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05395969
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.05029071
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04535840
25ER_23166858_ChIP-Seq_MCF-7_Human2.03493516
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03225269
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01188768
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99502521
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.99379225
30EWS_26573619_Chip-Seq_HEK293_Human1.96904396
31GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.95051932
32CBP_20019798_ChIP-Seq_JUKART_Human1.88927991
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.88927991
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87302681
35GBX2_23144817_ChIP-Seq_PC3_Human1.86488272
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82891233
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80989867
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78721046
39TAF15_26573619_Chip-Seq_HEK293_Human1.76265596
40STAT3_23295773_ChIP-Seq_U87_Human1.73649324
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72333923
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69897376
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66528997
44TCF4_23295773_ChIP-Seq_U87_Human1.64935101
45* REST_21632747_ChIP-Seq_MESCs_Mouse1.63761011
46RXR_22108803_ChIP-Seq_LS180_Human1.61369730
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61092221
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.59338799
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58671589
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56310585
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56157710
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54957646
53DROSHA_22980978_ChIP-Seq_HELA_Human1.53114578
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51305283
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.50599035
56IRF1_19129219_ChIP-ChIP_H3396_Human1.50019850
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49976343
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.49174655
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47839117
60* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46485846
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.45913872
62AR_21572438_ChIP-Seq_LNCaP_Human1.45642520
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.44210197
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.43359147
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43173411
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43173411
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42465077
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40546676
69P300_19829295_ChIP-Seq_ESCs_Human1.39730162
70SOX2_19829295_ChIP-Seq_ESCs_Human1.38944574
71NANOG_19829295_ChIP-Seq_ESCs_Human1.38944574
72TCF4_22108803_ChIP-Seq_LS180_Human1.38505689
73RUNX2_22187159_ChIP-Seq_PCA_Human1.36324337
74TP53_22573176_ChIP-Seq_HFKS_Human1.35656500
75* RNF2_27304074_Chip-Seq_NSC_Mouse1.34339731
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33826299
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.32075073
78* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31531672
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.31296089
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30642616
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.25818738
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25132060
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25052592
84SMAD4_21799915_ChIP-Seq_A2780_Human1.24486944
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.23006155
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21996578
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21824037
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.21824037
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.21613118
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.20377232
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.20276038
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19711777
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.17436723
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16970515
95NCOR_22424771_ChIP-Seq_293T_Human1.16667414
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16647206
97AR_20517297_ChIP-Seq_VCAP_Human1.16088665
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.16017716
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15941760
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15010895
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.14752137
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13740976
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13685149
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10520170
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09259114
106AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08282585
107* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07745037
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07330373
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07228805
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.06607988
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06229308
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05055670
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.04862454
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04848729
115CDX2_22108803_ChIP-Seq_LS180_Human1.04845552
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03032405
117* FLI1_21867929_ChIP-Seq_TH2_Mouse1.02970911
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02361478
119P53_22387025_ChIP-Seq_ESCs_Mouse1.02128061
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01619935
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00799564
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00707144
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99968201
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.99870778
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99442885
126AR_25329375_ChIP-Seq_VCAP_Human0.98464756
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.98190560
128* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97663878
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.97545799
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97501564
131TP53_16413492_ChIP-PET_HCT116_Human0.96875238
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96413713
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95815800
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95315499
135MYC_18940864_ChIP-ChIP_HL60_Human0.94430754
136BCAT_22108803_ChIP-Seq_LS180_Human0.93585061
137HOXB7_26014856_ChIP-Seq_BT474_Human0.93566813
138ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90749385
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90542853
140CTCF_27219007_Chip-Seq_Bcells_Human0.90108148
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.89246708
142TP53_18474530_ChIP-ChIP_U2OS_Human0.88648182
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88026609
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87703111
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86344867
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84751950
147AHR_22903824_ChIP-Seq_MCF-7_Human0.84187816
148JUN_21703547_ChIP-Seq_K562_Human0.83753028
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.82030230
150SMAD_19615063_ChIP-ChIP_OVARY_Human0.80663709
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78950195
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78847407
153RING1B_27294783_Chip-Seq_NPCs_Mouse0.78725281
154VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77605788
155TAL1_26923725_Chip-Seq_HPCs_Mouse0.76774776
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76480796
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76011298
158TET1_21490601_ChIP-Seq_MESCs_Mouse0.75854083
159PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75189586
160TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74944129
161KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74572758
162VDR_24787735_ChIP-Seq_THP-1_Human0.73269730
163TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72327998
164PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71795231
165NANOG_18555785_Chip-Seq_ESCs_Mouse0.71373772
166CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.71207884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001501_abnormal_sleep_pattern7.27414806
2MP0008775_abnormal_heart_ventricle4.46713585
3MP0006276_abnormal_autonomic_nervous4.37362224
4MP0002138_abnormal_hepatobiliary_system3.76974702
5MP0002733_abnormal_thermal_nociception3.66856621
6MP0004859_abnormal_synaptic_plasticity3.50466642
7MP0005535_abnormal_body_temperature3.16311948
8MP0005410_abnormal_fertilization3.12451371
9MP0003329_amyloid_beta_deposits3.06495665
10MP0005330_cardiomyopathy2.98779780
11MP0000372_irregular_coat_pigmentation2.97210127
12MP0006292_abnormal_olfactory_placode2.80393408
13MP0002272_abnormal_nervous_system2.77554433
14MP0003011_delayed_dark_adaptation2.76477753
15MP0000569_abnormal_digit_pigmentation2.72295388
16MP0004742_abnormal_vestibular_system2.68025719
17MP0004145_abnormal_muscle_electrophysio2.61205009
18MP0003123_paternal_imprinting2.38432120
19MP0003195_calcinosis2.36578471
20MP0001486_abnormal_startle_reflex2.36193017
21MP0003635_abnormal_synaptic_transmissio2.36185609
22MP0002572_abnormal_emotion/affect_behav2.31784253
23MP0005646_abnormal_pituitary_gland2.30376790
24MP0004381_abnormal_hair_follicle2.19991181
25MP0003879_abnormal_hair_cell2.12306732
26MP0000427_abnormal_hair_cycle2.11571212
27MP0002063_abnormal_learning/memory/cond2.11109705
28MP0003718_maternal_effect2.02400292
29MP0004142_abnormal_muscle_tone2.00617758
30MP0003122_maternal_imprinting2.00525005
31MP0000604_amyloidosis1.92011107
32MP0003136_yellow_coat_color1.88923970
33MP0008872_abnormal_physiological_respon1.84891924
34MP0002064_seizures1.79958819
35MP0004270_analgesia1.77519420
36MP0004924_abnormal_behavior1.76611745
37MP0005386_behavior/neurological_phenoty1.76611745
38MP0005075_abnormal_melanosome_morpholog1.76589487
39MP0001905_abnormal_dopamine_level1.76105883
40MP0009046_muscle_twitch1.75165149
41MP0008004_abnormal_stomach_pH1.69090769
42MP0002796_impaired_skin_barrier1.68576086
43MP0003698_abnormal_male_reproductive1.68559907
44MP0005174_abnormal_tail_pigmentation1.65534881
45MP0005503_abnormal_tendon_morphology1.62767180
46MP0009745_abnormal_behavioral_response1.62307766
47MP0002938_white_spotting1.62017342
48MP0004043_abnormal_pH_regulation1.61256964
49MP0002909_abnormal_adrenal_gland1.60223142
50MP0002736_abnormal_nociception_after1.59070319
51MP0001929_abnormal_gametogenesis1.59062632
52MP0005645_abnormal_hypothalamus_physiol1.58838750
53MP0006054_spinal_hemorrhage1.58278548
54MP0003880_abnormal_central_pattern1.56519572
55MP0004147_increased_porphyrin_level1.55629164
56MP0002102_abnormal_ear_morphology1.51012629
57MP0001968_abnormal_touch/_nociception1.47537483
58MP0002067_abnormal_sensory_capabilities1.47322233
59MP0010386_abnormal_urinary_bladder1.44837671
60MP0002210_abnormal_sex_determination1.41605787
61MP0001440_abnormal_grooming_behavior1.40737409
62MP0001986_abnormal_taste_sensitivity1.40445695
63MP0003632_abnormal_nervous_system1.39583232
64MP0005253_abnormal_eye_physiology1.35726720
65MP0000383_abnormal_hair_follicle1.33930799
66MP0008057_abnormal_DNA_replication1.31521817
67MP0002928_abnormal_bile_duct1.30078034
68MP0008877_abnormal_DNA_methylation1.28331267
69MP0008058_abnormal_DNA_repair1.27480641
70MP0002557_abnormal_social/conspecific_i1.26777630
71MP0002160_abnormal_reproductive_system1.25769525
72MP0002184_abnormal_innervation1.23957871
73MP0000013_abnormal_adipose_tissue1.23444930
74MP0002095_abnormal_skin_pigmentation1.22935678
75MP0004510_myositis1.21912145
76MP0001963_abnormal_hearing_physiology1.19960795
77MP0002876_abnormal_thyroid_physiology1.19602298
78MP0005220_abnormal_exocrine_pancreas1.19142025
79MP0002653_abnormal_ependyma_morphology1.18798776
80MP0004130_abnormal_muscle_cell1.18315246
81MP0000015_abnormal_ear_pigmentation1.16650981
82MP0002066_abnormal_motor_capabilities/c1.15564331
83MP0003787_abnormal_imprinting1.15101536
84MP0008789_abnormal_olfactory_epithelium1.14877715
85MP0003724_increased_susceptibility_to1.14577647
86MP0002882_abnormal_neuron_morphology1.14492511
87MP0005171_absent_coat_pigmentation1.13751474
88MP0001485_abnormal_pinna_reflex1.12793681
89MP0000653_abnormal_sex_gland1.12603515
90MP0008875_abnormal_xenobiotic_pharmacok1.11749798
91MP0002735_abnormal_chemical_nociception1.10667288
92MP0002234_abnormal_pharynx_morphology1.09847867
93MP0001502_abnormal_circadian_rhythm1.06835054
94MP0000631_abnormal_neuroendocrine_gland1.05777197
95MP0001529_abnormal_vocalization1.05537729
96MP0002132_abnormal_respiratory_system1.05282756
97MP0001324_abnormal_eye_pigmentation1.04577058
98MP0004185_abnormal_adipocyte_glucose1.04259354
99MP0005310_abnormal_salivary_gland1.02727216
100MP0009780_abnormal_chondrocyte_physiolo1.02552308
101MP0005167_abnormal_blood-brain_barrier1.01792090
102MP0000026_abnormal_inner_ear1.00831095
103MP0005083_abnormal_biliary_tract1.00383399
104MP0001145_abnormal_male_reproductive1.00291235
105MP0002229_neurodegeneration0.99729019
106MP0003252_abnormal_bile_duct0.99531738
107MP0002972_abnormal_cardiac_muscle0.97468699
108MP0003075_altered_response_to0.96048773
109MP0001970_abnormal_pain_threshold0.95625166
110MP0004085_abnormal_heartbeat0.94506503
111MP0003121_genomic_imprinting0.93864159
112MP0003878_abnormal_ear_physiology0.93811878
113MP0005377_hearing/vestibular/ear_phenot0.93811878
114MP0000747_muscle_weakness0.93674393
115MP0003950_abnormal_plasma_membrane0.93582474
116MP0003283_abnormal_digestive_organ0.90915902
117MP0000751_myopathy0.90613303
118MP0005394_taste/olfaction_phenotype0.89904426
119MP0005499_abnormal_olfactory_system0.89904426
120MP0000920_abnormal_myelination0.87504318
121MP0005620_abnormal_muscle_contractility0.86642106
122MP0006035_abnormal_mitochondrial_morpho0.85008477
123MP0005195_abnormal_posterior_eye0.84153898
124MP0005395_other_phenotype0.83862480
125MP0005647_abnormal_sex_gland0.83205734
126MP0010329_abnormal_lipoprotein_level0.82564977
127MP0005389_reproductive_system_phenotype0.81011102
128MP0004885_abnormal_endolymph0.80999606
129MP0005085_abnormal_gallbladder_physiolo0.80735505
130MP0000778_abnormal_nervous_system0.80584646
131MP0001664_abnormal_digestion0.78950224
132MP0001764_abnormal_homeostasis0.78673535
133MP0008995_early_reproductive_senescence0.77331366
134MP0005379_endocrine/exocrine_gland_phen0.76511280
135MP0003183_abnormal_peptide_metabolism0.76405902
136MP0000647_abnormal_sebaceous_gland0.75077850
137MP0003303_peritoneal_inflammation0.71269261
138MP0003631_nervous_system_phenotype0.67991638
139MP0005084_abnormal_gallbladder_morpholo0.63839037
140MP0002971_abnormal_brown_adipose0.63086218
141MP0000230_abnormal_systemic_arterial0.62059635
142MP0002837_dystrophic_cardiac_calcinosis0.61583610
143MP0003938_abnormal_ear_development0.60024510
144MP0002638_abnormal_pupillary_reflex0.59425304
145MP0001851_eye_inflammation0.58831771
146MP0000639_abnormal_adrenal_gland0.57680041
147MP0009697_abnormal_copulation0.56282442
148MP0001984_abnormal_olfaction0.56056701
149MP0008874_decreased_physiological_sensi0.55600275
150MP0000955_abnormal_spinal_cord0.54565550
151MP0002118_abnormal_lipid_homeostasis0.53045716
152MP0002752_abnormal_somatic_nervous0.52537223
153MP0003953_abnormal_hormone_level0.50866066
154MP0005670_abnormal_white_adipose0.50626487
155MP0005551_abnormal_eye_electrophysiolog0.50437871
156MP0008569_lethality_at_weaning0.50430271
157MP0002163_abnormal_gland_morphology0.50408476
158MP0002090_abnormal_vision0.47915156
159MP0005408_hypopigmentation0.47856604

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)9.98563344
2Limb hypertonia (HP:0002509)9.90805377
3Pancreatic cysts (HP:0001737)4.70141087
4Pancreatic fibrosis (HP:0100732)4.66656337
5Increased hepatocellular lipid droplets (HP:0006565)4.62804383
6True hermaphroditism (HP:0010459)4.61952386
7Lipid accumulation in hepatocytes (HP:0006561)4.29120238
8Spinal muscular atrophy (HP:0007269)4.20990915
9Increased intramyocellular lipid droplets (HP:0012240)3.99399321
10Abnormality of midbrain morphology (HP:0002418)3.98512171
11Molar tooth sign on MRI (HP:0002419)3.98512171
12Nephronophthisis (HP:0000090)3.95351431
13Congenital stationary night blindness (HP:0007642)3.92669478
14Medial flaring of the eyebrow (HP:0010747)3.59555597
15Abnormality of the renal medulla (HP:0100957)3.57088829
16Increased muscle lipid content (HP:0009058)3.53972767
17Cystic liver disease (HP:0006706)3.43634514
18Decreased central vision (HP:0007663)3.37533063
19Choreoathetosis (HP:0001266)3.33026390
20Abnormality of the renal cortex (HP:0011035)3.25732732
21Aplasia/Hypoplasia of the tongue (HP:0010295)3.16144146
22Attenuation of retinal blood vessels (HP:0007843)3.15462534
23Renal Fanconi syndrome (HP:0001994)3.14776417
24Supranuclear gaze palsy (HP:0000605)3.12221132
25Abnormal rod and cone electroretinograms (HP:0008323)3.09988904
26Systemic lupus erythematosus (HP:0002725)3.09603795
27Gastroesophageal reflux (HP:0002020)3.06835163
28Gait imbalance (HP:0002141)3.06739421
29Chronic hepatic failure (HP:0100626)3.04564824
30Neurofibrillary tangles (HP:0002185)3.01505860
31Keratoconus (HP:0000563)2.99998789
32Increased corneal curvature (HP:0100692)2.99998789
33Congenital primary aphakia (HP:0007707)2.97824622
34Nephrogenic diabetes insipidus (HP:0009806)2.95394896
35Hypotension (HP:0002615)2.88445112
36Congenital hepatic fibrosis (HP:0002612)2.79271130
37Type II lissencephaly (HP:0007260)2.75584319
38Agitation (HP:0000713)2.74282854
39Cerebral inclusion bodies (HP:0100314)2.62314371
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.61873990
41Poor suck (HP:0002033)2.61808795
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60890103
43Exertional dyspnea (HP:0002875)2.58705382
44Congenital sensorineural hearing impairment (HP:0008527)2.57239359
45J-shaped sella turcica (HP:0002680)2.56723330
46Renal cortical cysts (HP:0000803)2.56022567
47Focal seizures (HP:0007359)2.54809376
48Sclerocornea (HP:0000647)2.52546083
49Bony spicule pigmentary retinopathy (HP:0007737)2.52541569
50Abnormal biliary tract physiology (HP:0012439)2.52411790
51Bile duct proliferation (HP:0001408)2.52411790
52Postaxial foot polydactyly (HP:0001830)2.51020646
53Pigmentary retinal degeneration (HP:0001146)2.48703992
54Abolished electroretinogram (ERG) (HP:0000550)2.46918614
55Genetic anticipation (HP:0003743)2.46783423
56Hypokinesia (HP:0002375)2.46009947
57Frequent falls (HP:0002359)2.45832319
58Genital tract atresia (HP:0001827)2.45164563
59Abnormality of the pupil (HP:0000615)2.45001698
60Spastic paraparesis (HP:0002313)2.44242852
61Focal motor seizures (HP:0011153)2.38243842
62Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37505217
63Oligomenorrhea (HP:0000876)2.37277731
64Gaze-evoked nystagmus (HP:0000640)2.36314085
65Generalized hypotonia (HP:0001290)2.36305702
66Irritability (HP:0000737)2.34241835
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33770655
68Upper limb muscle weakness (HP:0003484)2.33626613
69Atonic seizures (HP:0010819)2.31574811
70Mitral stenosis (HP:0001718)2.31407023
71Muscular hypotonia of the trunk (HP:0008936)2.31099806
72Polydipsia (HP:0001959)2.30206383
73Abnormal drinking behavior (HP:0030082)2.30206383
74Polyphagia (HP:0002591)2.29598835
75Abnormality of macular pigmentation (HP:0008002)2.29110763
76Furrowed tongue (HP:0000221)2.27535040
77Arterial tortuosity (HP:0005116)2.27026045
78Male pseudohermaphroditism (HP:0000037)2.24167851
79Emotional lability (HP:0000712)2.22722031
80Vaginal atresia (HP:0000148)2.22615904
81Fair hair (HP:0002286)2.20850038
82Anencephaly (HP:0002323)2.20242993
83Glomerulonephritis (HP:0000099)2.18786301
84Tubulointerstitial nephritis (HP:0001970)2.16254501
85Poor coordination (HP:0002370)2.15449295
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13932636
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13729104
88Difficulty running (HP:0009046)2.13638777
89Myokymia (HP:0002411)2.13080169
90Cerebral hemorrhage (HP:0001342)2.11975660
91Abnormality of complement system (HP:0005339)2.11696088
92Hyperventilation (HP:0002883)2.11606982
93Dyschromatopsia (HP:0007641)2.11530334
94Severe visual impairment (HP:0001141)2.09797569
95Spontaneous abortion (HP:0005268)2.08923772
96Absent/shortened dynein arms (HP:0200106)2.08026879
97Dynein arm defect of respiratory motile cilia (HP:0012255)2.08026879
98Retinitis pigmentosa (HP:0000510)2.07698423
99Azoospermia (HP:0000027)2.07630994
100Progressive cerebellar ataxia (HP:0002073)2.06870446
101Complement deficiency (HP:0004431)2.06589097
102Retinal dysplasia (HP:0007973)2.05548299
103Partial agenesis of the corpus callosum (HP:0001338)2.03756302
104Amyloidosis (HP:0011034)2.02417992
105Prostate neoplasm (HP:0100787)2.02318402
106Deep venous thrombosis (HP:0002625)2.01483858
107Methylmalonic aciduria (HP:0012120)2.01253876
108Hypothermia (HP:0002045)13.4200315
109Abnormal pupillary function (HP:0007686)11.3168851
110Generalized tonic-clonic seizures (HP:0002069)1.99548692
111Cone-rod dystrophy (HP:0000548)1.99387174
112Visual hallucinations (HP:0002367)1.98590468
113Short tibia (HP:0005736)1.98457339
114Astigmatism (HP:0000483)1.97579085
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96230621
116Myoclonus (HP:0001336)1.95605140
117Abnormal ciliary motility (HP:0012262)1.95472931
118Progressive inability to walk (HP:0002505)1.94700210
119Vascular tortuosity (HP:0004948)1.94609912
120Respiratory difficulties (HP:0002880)1.94096075
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93774430
122Abnormal protein N-linked glycosylation (HP:0012347)1.93774430
123Abnormal protein glycosylation (HP:0012346)1.93774430
124Abnormal glycosylation (HP:0012345)1.93774430
125Amelogenesis imperfecta (HP:0000705)1.93658895
126Xanthomatosis (HP:0000991)1.89627729
127Decreased circulating renin level (HP:0003351)1.87770089
128Postaxial hand polydactyly (HP:0001162)1.87744138
129Lissencephaly (HP:0001339)1.87429265
130Dialeptic seizures (HP:0011146)1.87349267
131Abnormality of the labia minora (HP:0012880)1.86139620
132Peritonitis (HP:0002586)1.85804008
133Generalized hypopigmentation of hair (HP:0011358)1.84246930
134Large earlobe (HP:0009748)1.84018700
135Hypoplasia of the fovea (HP:0007750)1.83559243
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.83559243
137Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83056717
138Vertebral hypoplasia (HP:0008417)1.83056717
139Prominent nasal bridge (HP:0000426)1.82667745
140Anomalous pulmonary venous return (HP:0010772)1.81834792
141EMG: neuropathic changes (HP:0003445)1.79775515
142Oculomotor apraxia (HP:0000657)1.79393913
143Polyuria (HP:0000103)1.78827017
144Widely spaced teeth (HP:0000687)1.77774246
145Tubular atrophy (HP:0000092)1.75945390
146Volvulus (HP:0002580)1.75689526
147Preaxial hand polydactyly (HP:0001177)1.74590099
148Abnormal respiratory motile cilium morphology (HP:0005938)1.73699679
149Abnormal respiratory epithelium morphology (HP:0012253)1.73699679
150Tubulointerstitial abnormality (HP:0001969)1.73243230
151Increased CSF lactate (HP:0002490)1.72636455
152Dyskinesia (HP:0100660)1.72528687
153Concave nail (HP:0001598)1.72213744
154Generalized aminoaciduria (HP:0002909)1.71834657
155Cerebellar dysplasia (HP:0007033)1.71826086
156Absent speech (HP:0001344)1.71084596
157Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70611141
158Occipital encephalocele (HP:0002085)1.70391231
159Obstructive sleep apnea (HP:0002870)1.68536957
160Diminished movement (HP:0002374)1.67786271
161Sloping forehead (HP:0000340)1.67396360
162Febrile seizures (HP:0002373)1.65375564
163Wrist flexion contracture (HP:0001239)1.65010773
164Absence seizures (HP:0002121)1.64969394
165Epileptic encephalopathy (HP:0200134)1.63693286
166Abnormal eating behavior (HP:0100738)1.63102913
167Paraparesis (HP:0002385)1.62312385
168Calf muscle hypertrophy (HP:0008981)1.60763108
169Esotropia (HP:0000565)1.60456520
170Tachypnea (HP:0002789)1.58727753
171Abnormality of renal resorption (HP:0011038)1.58087096
172Abnormality of the lumbar spine (HP:0100712)1.57712305
173Methylmalonic acidemia (HP:0002912)1.55806014
174Broad distal phalanx of finger (HP:0009836)1.54447838
175Enlarged penis (HP:0000040)1.54170176
176Abnormality of the pulmonary veins (HP:0011718)1.53827456
177Septate vagina (HP:0001153)1.52178920
178Hyperphosphaturia (HP:0003109)1.51670255
179Sleep apnea (HP:0010535)1.50620981
180Failure to thrive in infancy (HP:0001531)1.50540341
181Late onset (HP:0003584)1.49815521
182Hypokalemic alkalosis (HP:0001949)1.48374461
183Vertebral arch anomaly (HP:0008438)1.48344944
184Anosmia (HP:0000458)1.47795551
185Leukodystrophy (HP:0002415)1.47197993
186Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.47085075
187Abnormality of the axillary hair (HP:0100134)1.46856846
188Abnormality of secondary sexual hair (HP:0009888)1.46856846
189Centrally nucleated skeletal muscle fibers (HP:0003687)1.45357333
190Acute necrotizing encephalopathy (HP:0006965)1.45028355
191Cervical subluxation (HP:0003308)1.44717875
192Palpitations (HP:0001962)1.44032584
193Long toe (HP:0010511)1.43662135
194Glycosuria (HP:0003076)1.43425499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.34612571
2NTRK33.63826672
3UHMK13.33101318
4PNCK3.26616218
5MAP4K23.02661862
6MINK12.96562892
7ACVR1B2.96302844
8TAOK32.90975752
9BMPR1B2.61173734
10CAMK2A2.52259317
11ADRBK22.49842351
12MAPKAPK52.44601876
13EPHA42.42901374
14ZAK2.40971499
15TRIB32.40334402
16LMTK22.18472927
17SIK22.18034365
18STK38L2.14902389
19INSRR2.14574785
20MAP3K42.08712895
21WNK32.06890539
22TNIK2.01156240
23NTRK12.00620060
24CDK191.91832487
25MAP2K41.88872059
26PAK31.88159125
27MUSK1.87913290
28TLK11.86582505
29MST1R1.83605362
30STK391.78004928
31DMPK1.77804403
32EPHB11.70097780
33MAP3K91.66849379
34MAP4K11.59053654
35FLT31.56072488
36RIPK41.54608677
37GRK11.48677536
38LATS21.48035664
39CLK11.45905916
40PRKG11.44289236
41PTK2B1.41412827
42PLK21.40746956
43CSNK1G31.39120304
44PLK41.37596589
45MKNK21.36499286
46MARK11.35678462
47CAMK1G1.35274673
48EEF2K1.31774548
49MAPK121.29948815
50CSNK1G21.21971103
51CSNK1G11.21314910
52RIPK11.19812093
53VRK11.19586347
54LATS11.18963127
55TRIM281.18477280
56PRKCE1.16598124
57NUAK11.16460765
58FES1.14489448
59PHKG11.09620338
60PHKG21.09620338
61STK111.09327475
62TEC1.08816695
63BCKDK1.05365455
64PDPK11.04998941
65ALK1.03809898
66PKN11.03106722
67CASK1.00304490
68MAPK91.00223495
69CDK50.98600647
70LRRK20.98193962
71NTRK20.96769434
72FER0.96063643
73MARK20.94655856
74SRPK10.93683014
75PINK10.92697782
76PDK10.92129321
77PRKCZ0.89231649
78PIK3CG0.89024262
79OXSR10.88830125
80DAPK20.87458833
81MAPK130.84491914
82CAMK40.83887330
83NME10.82145000
84PAK60.80373304
85MAP2K70.79242170
86MAP3K20.78651781
87GRK70.78275416
88SIK10.77991566
89WEE10.77950595
90MST40.77212742
91BRSK20.77141292
92CAMK10.76222825
93STK30.75731580
94TAF10.72530720
95PRKCG0.72366454
96TYRO30.71808030
97MKNK10.70820577
98CCNB10.69046128
99ERBB30.68869235
100WNK40.67406916
101BCR0.67096800
102STK380.66772298
103GRK60.66584988
104KIT0.65268653
105IRAK10.64753374
106CAMK1D0.64719249
107CDK140.64461989
108NME20.64456214
109MET0.64372568
110ROCK20.63979636
111MAP3K130.63921408
112SCYL20.63186868
113MAPK30.63179827
114MAPK40.63093187
115PRKCA0.61758317
116ADRBK10.61659491
117MAPK70.60684705
118FGR0.60580521
119TGFBR10.60326569
120GRK50.59495709
121PRKCH0.58064242
122TNK20.58039814
123TTN0.57455179
124ILK0.57105283
125BMX0.56749811
126STK240.55737411
127ERN10.54958072
128MAP2K10.54445692
129PKN20.54334339
130DDR20.54163855
131CAMKK20.53889874
132IKBKB0.53364752
133PTK60.51858022
134RPS6KA20.51383727
135BLK0.50733665
136FYN0.46425084
137PRKCI0.45244977
138TXK0.45098219
139RET0.44550280
140TIE10.44266101
141ATR0.43266532
142MAP3K120.42284684
143STK160.41517106
144JAK20.41459724
145PIK3CA0.40384866
146CSNK1E0.39024845
147CSF1R0.38883729
148MARK30.38867872
149CSNK1D0.38808430
150PRKACA0.38148381
151PLK30.38044560
152PRKAA10.37376209
153PRKG20.37340988
154PDGFRB0.37127523
155EIF2AK30.37027888
156CDK30.36613826
157CHUK0.35941738
158MAPK10.35916002
159MAPKAPK30.34581355
160RPS6KA50.33838470
161CAMKK10.33772191
162FGFR20.33409944
163RPS6KA30.33402643
164CSNK1A1L0.32113886
165DYRK1A0.31377960
166PRKCQ0.31246125
167PLK10.30234823
168PRKD10.29100979
169ATM0.28743939
170PRKCB0.28178129

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.63739245
2Histidine metabolism_Homo sapiens_hsa003405.17102894
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.70600161
4Fatty acid elongation_Homo sapiens_hsa000624.15204440
5Phototransduction_Homo sapiens_hsa047443.58278234
6Sulfur relay system_Homo sapiens_hsa041223.48889600
7Serotonergic synapse_Homo sapiens_hsa047263.29632543
8Steroid biosynthesis_Homo sapiens_hsa001003.16101183
9Tyrosine metabolism_Homo sapiens_hsa003502.82801444
10Tryptophan metabolism_Homo sapiens_hsa003802.56908191
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.56728889
12Cocaine addiction_Homo sapiens_hsa050302.51951532
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.41407132
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30024799
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15674878
16Homologous recombination_Homo sapiens_hsa034402.09145685
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08214248
18Nitrogen metabolism_Homo sapiens_hsa009102.07259553
19Fatty acid metabolism_Homo sapiens_hsa012121.97605748
20Fatty acid biosynthesis_Homo sapiens_hsa000611.84082640
21Amphetamine addiction_Homo sapiens_hsa050311.81640382
22ABC transporters_Homo sapiens_hsa020101.81194069
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80622756
24Basal transcription factors_Homo sapiens_hsa030221.78566012
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68574669
26Fanconi anemia pathway_Homo sapiens_hsa034601.64262887
27Ether lipid metabolism_Homo sapiens_hsa005651.64197588
28Dopaminergic synapse_Homo sapiens_hsa047281.53175096
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52079360
30Caffeine metabolism_Homo sapiens_hsa002321.49583237
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46570250
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38417649
33Selenocompound metabolism_Homo sapiens_hsa004501.32301835
34Butanoate metabolism_Homo sapiens_hsa006501.30521422
35Synaptic vesicle cycle_Homo sapiens_hsa047211.25581642
36Staphylococcus aureus infection_Homo sapiens_hsa051501.22687195
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15050667
38Arachidonic acid metabolism_Homo sapiens_hsa005901.13036772
39GABAergic synapse_Homo sapiens_hsa047271.11681520
40Regulation of autophagy_Homo sapiens_hsa041401.07435221
41Non-homologous end-joining_Homo sapiens_hsa034501.06355240
42Pentose phosphate pathway_Homo sapiens_hsa000301.01730704
43RNA polymerase_Homo sapiens_hsa030200.95995398
44beta-Alanine metabolism_Homo sapiens_hsa004100.95978149
45One carbon pool by folate_Homo sapiens_hsa006700.95241217
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93453206
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.89147810
48Purine metabolism_Homo sapiens_hsa002300.89006421
49Calcium signaling pathway_Homo sapiens_hsa040200.84245279
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.83100186
51Fatty acid degradation_Homo sapiens_hsa000710.80259349
52Salivary secretion_Homo sapiens_hsa049700.80179038
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79370424
54Collecting duct acid secretion_Homo sapiens_hsa049660.78638800
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.77530597
56Gap junction_Homo sapiens_hsa045400.75324154
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73831992
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73290048
59Morphine addiction_Homo sapiens_hsa050320.73223215
60Renin secretion_Homo sapiens_hsa049240.72439026
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72089082
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72070809
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71923165
64Dorso-ventral axis formation_Homo sapiens_hsa043200.70414611
65Oxidative phosphorylation_Homo sapiens_hsa001900.69919567
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69626894
67Glutamatergic synapse_Homo sapiens_hsa047240.69479133
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69074287
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68911605
70Metabolic pathways_Homo sapiens_hsa011000.67300630
71Pancreatic secretion_Homo sapiens_hsa049720.66054258
72Protein export_Homo sapiens_hsa030600.65665416
73Ovarian steroidogenesis_Homo sapiens_hsa049130.64310844
74Mismatch repair_Homo sapiens_hsa034300.64081594
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.63972923
76GnRH signaling pathway_Homo sapiens_hsa049120.63612163
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.63256415
78Sphingolipid metabolism_Homo sapiens_hsa006000.63012832
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.62980514
80RNA degradation_Homo sapiens_hsa030180.62919457
81Huntingtons disease_Homo sapiens_hsa050160.62718847
82Pyrimidine metabolism_Homo sapiens_hsa002400.60780247
83Long-term depression_Homo sapiens_hsa047300.60347653
84Cardiac muscle contraction_Homo sapiens_hsa042600.58410986
85PPAR signaling pathway_Homo sapiens_hsa033200.58184149
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57724590
87Asthma_Homo sapiens_hsa053100.56355036
88Glycerolipid metabolism_Homo sapiens_hsa005610.56338298
89Circadian entrainment_Homo sapiens_hsa047130.55860966
90Nicotine addiction_Homo sapiens_hsa050330.55139892
91Oxytocin signaling pathway_Homo sapiens_hsa049210.53510510
92Oocyte meiosis_Homo sapiens_hsa041140.52664776
93Glutathione metabolism_Homo sapiens_hsa004800.51852664
94Retinol metabolism_Homo sapiens_hsa008300.51530866
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50697794
96Linoleic acid metabolism_Homo sapiens_hsa005910.50602252
97Insulin secretion_Homo sapiens_hsa049110.49422715
98Olfactory transduction_Homo sapiens_hsa047400.49289079
99Base excision repair_Homo sapiens_hsa034100.47694070
100Circadian rhythm_Homo sapiens_hsa047100.47507649
101Type I diabetes mellitus_Homo sapiens_hsa049400.47454799
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46862297
103Estrogen signaling pathway_Homo sapiens_hsa049150.46584153
104Sulfur metabolism_Homo sapiens_hsa009200.45143919
105Parkinsons disease_Homo sapiens_hsa050120.44836549
106Cholinergic synapse_Homo sapiens_hsa047250.44140056
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43759997
108Alzheimers disease_Homo sapiens_hsa050100.43636126
109Peroxisome_Homo sapiens_hsa041460.42988770
110Fat digestion and absorption_Homo sapiens_hsa049750.41908777
111Taste transduction_Homo sapiens_hsa047420.41544880
112Complement and coagulation cascades_Homo sapiens_hsa046100.41082747
113Long-term potentiation_Homo sapiens_hsa047200.40024681
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39599549
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39005724
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38982422
117Gastric acid secretion_Homo sapiens_hsa049710.38766386
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37549309
119RNA transport_Homo sapiens_hsa030130.37404242
120Alcoholism_Homo sapiens_hsa050340.37143395
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37052193
122Phagosome_Homo sapiens_hsa041450.37046622
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36748145
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36250469
125Bile secretion_Homo sapiens_hsa049760.33286817
126N-Glycan biosynthesis_Homo sapiens_hsa005100.33100393
127Rheumatoid arthritis_Homo sapiens_hsa053230.32899714
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32547068
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.32232993
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32129450
131Vibrio cholerae infection_Homo sapiens_hsa051100.31570451
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31074728
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30391172
134Propanoate metabolism_Homo sapiens_hsa006400.28221105
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.27649174
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26309553
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26198698
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.22697395
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22166189
140Dilated cardiomyopathy_Homo sapiens_hsa054140.22045361
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21900431
142Pyruvate metabolism_Homo sapiens_hsa006200.21509757
143Chemical carcinogenesis_Homo sapiens_hsa052040.21432848
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19386951
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18966753
146MAPK signaling pathway_Homo sapiens_hsa040100.18526496
147Arginine and proline metabolism_Homo sapiens_hsa003300.18174053
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18107904
149Carbon metabolism_Homo sapiens_hsa012000.17873455
150Glucagon signaling pathway_Homo sapiens_hsa049220.15316136
151Salmonella infection_Homo sapiens_hsa051320.14895929
152Axon guidance_Homo sapiens_hsa043600.14453752
153Biosynthesis of amino acids_Homo sapiens_hsa012300.14178277
154Thyroid hormone synthesis_Homo sapiens_hsa049180.14048767
155Amoebiasis_Homo sapiens_hsa051460.13926193

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