OCM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of neurotransmitter secretion (GO:0046929)9.75387447
2negative regulation of amino acid transport (GO:0051956)9.71519221
3positive regulation of amino acid transport (GO:0051957)9.57968713
4positive regulation of catecholamine secretion (GO:0033605)8.92254584
5regulation of glutamate secretion (GO:0014048)7.39842974
6purine nucleobase biosynthetic process (GO:0009113)7.09192508
7mannose metabolic process (GO:0006013)7.07226320
8negative regulation of neurotransmitter transport (GO:0051589)6.92746588
9serotonin receptor signaling pathway (GO:0007210)6.34427676
10phenol-containing compound catabolic process (GO:0019336)6.28985075
11mitotic metaphase plate congression (GO:0007080)6.16283257
12negative regulation of calcium ion-dependent exocytosis (GO:0045955)6.01996427
13nucleobase biosynthetic process (GO:0046112)5.97602162
14opioid receptor signaling pathway (GO:0038003)5.87633620
15vitamin transmembrane transport (GO:0035461)5.86633192
16hormone catabolic process (GO:0042447)5.85313423
17ribosome assembly (GO:0042255)5.67388912
18branched-chain amino acid catabolic process (GO:0009083)5.65010643
19lung-associated mesenchyme development (GO:0060484)5.30789454
20Peyers patch development (GO:0048541)5.10997234
21mucosal-associated lymphoid tissue development (GO:0048537)5.10997234
22branched-chain amino acid metabolic process (GO:0009081)5.02427918
23regulation of spindle organization (GO:0090224)4.97031115
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.94171072
25ribosome biogenesis (GO:0042254)4.82977494
26pharyngeal system development (GO:0060037)4.72843542
27folic acid metabolic process (GO:0046655)4.67603591
28regulation of dopamine secretion (GO:0014059)4.58180340
29N-glycan processing (GO:0006491)4.55077443
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.55036418
31DNA replication checkpoint (GO:0000076)4.49948017
32regulation of membrane lipid distribution (GO:0097035)4.48380776
33folic acid transport (GO:0015884)4.46768574
34pyrimidine nucleotide catabolic process (GO:0006244)4.45957157
35metaphase plate congression (GO:0051310)4.44358093
36intestinal epithelial cell development (GO:0060576)4.39489649
37negative regulation of organic acid transport (GO:0032891)4.38064387
38termination of RNA polymerase III transcription (GO:0006386)4.37213988
39transcription elongation from RNA polymerase III promoter (GO:0006385)4.37213988
40thyroid hormone generation (GO:0006590)4.32347304
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32021363
42termination of RNA polymerase I transcription (GO:0006363)4.30370055
43transcription elongation from RNA polymerase I promoter (GO:0006362)4.29960439
44positive regulation of organic acid transport (GO:0032892)4.28574089
45regulation of amino acid transport (GO:0051955)4.22816174
467-methylguanosine mRNA capping (GO:0006370)4.19713699
47regulation of B cell receptor signaling pathway (GO:0050855)4.17044784
48rRNA modification (GO:0000154)4.10949180
49formation of translation preinitiation complex (GO:0001731)4.08778380
50negative regulation of amine transport (GO:0051953)4.08620372
51RNA capping (GO:0036260)4.05445110
527-methylguanosine RNA capping (GO:0009452)4.05445110
53transcription from RNA polymerase I promoter (GO:0006360)4.04938437
54protein localization to kinetochore (GO:0034501)4.02151329
55negative regulation of cAMP-mediated signaling (GO:0043951)3.99217062
56base-excision repair, AP site formation (GO:0006285)3.84865400
57muscle cell fate commitment (GO:0042693)3.84697982
58positive regulation of chromosome segregation (GO:0051984)3.78728132
59thyroid hormone metabolic process (GO:0042403)3.78371299
60transcription initiation from RNA polymerase I promoter (GO:0006361)3.77950514
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.75815555
62long-term synaptic potentiation (GO:0060291)3.74174929
63diterpenoid biosynthetic process (GO:0016102)3.73129164
64positive regulation of granulocyte differentiation (GO:0030854)3.73128539
65mature B cell differentiation involved in immune response (GO:0002313)3.70684927
66positive regulation of amine transport (GO:0051954)3.69469752
67negative regulation of erythrocyte differentiation (GO:0045647)3.65988675
68labyrinthine layer development (GO:0060711)3.65451581
69regulation of G0 to G1 transition (GO:0070316)3.64504456
70regulation of mitotic spindle organization (GO:0060236)3.62521145
71blastocyst development (GO:0001824)3.61921035
72negative regulation of protein tyrosine kinase activity (GO:0061099)3.61287368
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59450579
74modified amino acid transport (GO:0072337)3.57982456
75meiosis I (GO:0007127)3.57381731
76GMP metabolic process (GO:0046037)3.55557779
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54890876
78actin filament capping (GO:0051693)3.53804036
79ribonucleoprotein complex biogenesis (GO:0022613)3.51654807
80neutrophil activation involved in immune response (GO:0002283)3.47865182
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.46689376
82proteasome assembly (GO:0043248)3.45266963
83establishment of chromosome localization (GO:0051303)3.44526032
84autophagic vacuole assembly (GO:0000045)3.43556789
85transcription elongation from RNA polymerase II promoter (GO:0006368)3.41687149
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40288443
87spindle checkpoint (GO:0031577)3.39718913
88regulation of translation in response to stress (GO:0043555)3.38844118
89regulation of RNA export from nucleus (GO:0046831)3.38594279
90DNA-templated transcription, elongation (GO:0006354)3.38383490
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37102208
92protein localization to chromosome, centromeric region (GO:0071459)3.36918060
93urogenital system development (GO:0001655)3.35231103
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32001354
95polyamine biosynthetic process (GO:0006596)3.31245984
96maturation of SSU-rRNA (GO:0030490)3.30309459
97histone H2A monoubiquitination (GO:0035518)3.29398217
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27867725
99CDP-diacylglycerol metabolic process (GO:0046341)3.27217737
100regulation of exit from mitosis (GO:0007096)3.26330930
101regulation of transforming growth factor beta2 production (GO:0032909)3.25497838
102regulation of chromosome segregation (GO:0051983)3.23196827
103histone H4-K8 acetylation (GO:0043982)3.22944781
104histone H4-K5 acetylation (GO:0043981)3.22944781
105negative regulation of glycoprotein biosynthetic process (GO:0010561)3.22883438
106mature B cell differentiation (GO:0002335)3.21593418
107glycine metabolic process (GO:0006544)3.18640031
108behavioral response to ethanol (GO:0048149)3.18220029
109spliceosomal snRNP assembly (GO:0000387)3.17622549
110male meiosis I (GO:0007141)3.17614863
111maturation of 5.8S rRNA (GO:0000460)3.16236952
112regulation of cardioblast differentiation (GO:0051890)3.16221155
113rRNA processing (GO:0006364)3.15086582
114positive regulation of viral transcription (GO:0050434)3.12701342
115terpenoid biosynthetic process (GO:0016114)3.12628012
116negative regulation of fibroblast apoptotic process (GO:2000270)3.12101721
117mitotic spindle checkpoint (GO:0071174)3.10434012
118amine biosynthetic process (GO:0009309)3.09979975
119cellular biogenic amine biosynthetic process (GO:0042401)3.09979975
120pantothenate metabolic process (GO:0015939)3.09823303
121serine family amino acid catabolic process (GO:0009071)3.09169934
122epithelial cell fate commitment (GO:0072148)3.08289154
123rRNA methylation (GO:0031167)3.07610880
124rRNA metabolic process (GO:0016072)3.07364781
125positive regulation of gamma-delta T cell activation (GO:0046645)3.07215982
126antigen processing and presentation of endogenous antigen (GO:0019883)3.07141309
127regulation of mast cell degranulation (GO:0043304)3.06818630
128S-adenosylmethionine metabolic process (GO:0046500)3.06388758
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06281796
130piRNA metabolic process (GO:0034587)3.05950747
131pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.01530457
132SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.00819758
133cullin deneddylation (GO:0010388)3.00792973
134positive regulation of ligase activity (GO:0051351)2.99981421
135negative regulation of protein oligomerization (GO:0032460)2.99538219
136synaptonemal complex assembly (GO:0007130)2.99189377
137ventricular cardiac muscle cell development (GO:0055015)2.99141596
138CENP-A containing nucleosome assembly (GO:0034080)2.97013924
139DNA-dependent DNA replication (GO:0006261)2.96914654
140response to parathyroid hormone (GO:0071107)2.95258756
141L-methionine salvage (GO:0071267)2.95145049
142L-methionine biosynthetic process (GO:0071265)2.95145049
143amino acid salvage (GO:0043102)2.95145049
144attachment of spindle microtubules to kinetochore (GO:0008608)2.95134695
145protein localization to chromosome (GO:0034502)2.94466508
146early endosome to late endosome transport (GO:0045022)2.94407538
147guanosine-containing compound biosynthetic process (GO:1901070)2.93448444
148histone H2A ubiquitination (GO:0033522)2.93337487
149histone exchange (GO:0043486)2.92618730
150antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91432316
151negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90823284
152negative regulation of cell killing (GO:0031342)2.90823284
153histone-serine phosphorylation (GO:0035404)2.90332799
154mitotic spindle assembly checkpoint (GO:0007094)2.89968606
155regulation of double-strand break repair via homologous recombination (GO:0010569)2.89189050
156positive regulation of autophagy (GO:0010508)2.89040408
157regulation of mast cell activation involved in immune response (GO:0033006)2.88992185
158negative regulation of chromosome segregation (GO:0051985)2.88261777
159monoubiquitinated protein deubiquitination (GO:0035520)2.86587570
160regulation of granulocyte differentiation (GO:0030852)2.86193157
161biotin metabolic process (GO:0006768)2.85804627
162negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85742040
163protein deneddylation (GO:0000338)2.84884252
164pathway-restricted SMAD protein phosphorylation (GO:0060389)2.81561555
165outer ear morphogenesis (GO:0042473)2.80192119
166definitive hemopoiesis (GO:0060216)2.79456568
167microtubule nucleation (GO:0007020)2.78103844
168positive regulation of cAMP-mediated signaling (GO:0043950)2.75988559
169tolerance induction (GO:0002507)2.75222392
170regulation of protein glycosylation (GO:0060049)2.75026305
171negative regulation of actin filament depolymerization (GO:0030835)2.71051789
172regulation of mast cell activation (GO:0033003)2.70060814
173negative regulation of mast cell activation (GO:0033004)2.68714501
174regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68430670
175negative thymic T cell selection (GO:0045060)2.66801399
176positive thymic T cell selection (GO:0045059)2.65851768
177maintenance of protein location in nucleus (GO:0051457)2.65783437
178negative T cell selection (GO:0043383)2.65530574
179activated T cell proliferation (GO:0050798)2.65474852
180negative regulation of activin receptor signaling pathway (GO:0032926)2.61758151
181histone H4-K16 acetylation (GO:0043984)2.60626042
182protein K48-linked deubiquitination (GO:0071108)2.55550073
183positive regulation of interleukin-1 beta secretion (GO:0050718)2.54786765
184autophagic vacuole fusion (GO:0000046)2.54777355
185regulation of histone H3-K27 methylation (GO:0061085)2.53576308
186regulation of leukocyte degranulation (GO:0043300)2.53318603
187negative regulation of exocytosis (GO:0045920)2.52743499
188positive regulation of RNA splicing (GO:0033120)2.51332012
189leukocyte aggregation (GO:0070486)2.51271506
190ether lipid metabolic process (GO:0046485)2.47700025
191neutrophil activation (GO:0042119)2.45098495
192negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44910830
193antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44566970
194positive T cell selection (GO:0043368)2.40933008
195regulation of Golgi to plasma membrane protein transport (GO:0042996)2.40453483
196regulation of interleukin-1 beta secretion (GO:0050706)2.40251768
197cellular response to interleukin-15 (GO:0071350)2.39775044
198phospholipid scrambling (GO:0017121)10.2496868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.04324953
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.30266438
3IGF1R_20145208_ChIP-Seq_DFB_Human4.41945801
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.24713301
5E2F7_22180533_ChIP-Seq_HELA_Human4.14651489
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.69724955
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.62617065
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.60311160
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57748998
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.47480420
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.41799308
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.37480994
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31524550
14AR_21909140_ChIP-Seq_LNCAP_Human3.30360851
15GABP_17652178_ChIP-ChIP_JURKAT_Human3.20376170
16IRF8_22096565_ChIP-ChIP_GC-B_Human3.07694736
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07684204
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.90264484
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.61737933
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58259055
21ZNF263_19887448_ChIP-Seq_K562_Human2.53966336
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48415044
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47053153
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46485023
25ZNF274_21170338_ChIP-Seq_K562_Hela2.40176409
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39136074
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32847897
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32414678
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24219354
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.21539720
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.13152021
32VDR_23849224_ChIP-Seq_CD4+_Human2.06415973
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04766974
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00532428
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96899797
36XRN2_22483619_ChIP-Seq_HELA_Human1.94141123
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91751722
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90985292
39RUNX_20019798_ChIP-Seq_JUKART_Human1.89523457
40GABP_19822575_ChIP-Seq_HepG2_Human1.88056601
41SCL_19346495_ChIP-Seq_HPC-7_Human1.86270894
42RNF2_27304074_Chip-Seq_NSC_Mouse1.82566649
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76755041
44VDR_22108803_ChIP-Seq_LS180_Human1.75648453
45EWS_26573619_Chip-Seq_HEK293_Human1.75356498
46ER_23166858_ChIP-Seq_MCF-7_Human1.74921795
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74222694
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73917592
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.73741497
50GBX2_23144817_ChIP-Seq_PC3_Human1.69715913
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67408475
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.63563664
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.62166626
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61998776
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60549718
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59492607
57KDM5A_27292631_Chip-Seq_BREAST_Human1.59043952
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58310514
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.57961249
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57140228
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56669615
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.55926859
63DCP1A_22483619_ChIP-Seq_HELA_Human1.54384261
64GATA3_27048872_Chip-Seq_THYMUS_Human1.53084710
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51728497
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51523636
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.51504348
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50091360
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.48897405
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48275670
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48275670
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48275670
73TP53_22573176_ChIP-Seq_HFKS_Human1.47566795
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45612390
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45067126
76HTT_18923047_ChIP-ChIP_STHdh_Human1.43686660
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43207668
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.42038791
79* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39429018
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39237150
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39160577
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37600311
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36974867
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.36736081
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36033967
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.35508286
87TTF2_22483619_ChIP-Seq_HELA_Human1.32872851
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32710560
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.30758151
90DROSHA_22980978_ChIP-Seq_HELA_Human1.29937040
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29749098
92GATA3_26560356_Chip-Seq_TH1_Human1.29011103
93SPI1_23547873_ChIP-Seq_NB4_Human1.28717184
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27066717
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25635025
96GATA3_26560356_Chip-Seq_TH2_Human1.25605679
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22864401
98P300_19829295_ChIP-Seq_ESCs_Human1.19278557
99AR_21572438_ChIP-Seq_LNCaP_Human1.19157503
100FOXP3_21729870_ChIP-Seq_TREG_Human1.16749848
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16650597
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15558879
103MYB_26560356_Chip-Seq_TH2_Human1.14399952
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13109252
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12670196
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12421408
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11047762
108NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10669491
109REST_21632747_ChIP-Seq_MESCs_Mouse1.09645792
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09406234
111VDR_24787735_ChIP-Seq_THP-1_Human1.08372503
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08347061
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06454236
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.06064221
115NANOG_21062744_ChIP-ChIP_HESCs_Human1.05782724
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05370751
117ELK1_19687146_ChIP-ChIP_HELA_Human1.05060917
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.04674852
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04520134
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04356425
121RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04231486
122EZH2_22144423_ChIP-Seq_EOC_Human1.04119164
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03460012
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02651249
125TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02313741
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02169508
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02064858
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01504441
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00735362
130ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99290039
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99052540
132* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98868888
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98706409
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98389877
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98321086
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98013907
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97902742
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97852677
139SOX2_19829295_ChIP-Seq_ESCs_Human0.97648052
140NANOG_19829295_ChIP-Seq_ESCs_Human0.97648052
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97581748
142KDM2B_26808549_Chip-Seq_REH_Human0.97553990
143MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97512986
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97463443
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96791660
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96736724
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96249629
148POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95993255
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95745351
150NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95745351
151TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95255078
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95250052
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95250052
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95170143
155TAL1_26923725_Chip-Seq_HPCs_Mouse0.94255398
156RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94063106
157STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92280673
158SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92159776
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91678337
160KAP1_27257070_Chip-Seq_ESCs_Mouse0.91117497
161VDR_24763502_ChIP-Seq_THP-1_Human0.90971080
162BCAT_22108803_ChIP-Seq_LS180_Human0.90407903
163TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90230710
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89769432
165TAF15_26573619_Chip-Seq_HEK293_Human0.89736237
166ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89500194
167OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89293867
168RXR_22108803_ChIP-Seq_LS180_Human0.88109288
169SMAD_19615063_ChIP-ChIP_OVARY_Human0.87685371
170SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87652060
171SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87090530
172PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86928564
173NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86870248
174SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86420137
175TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85669178
176FOXH1_21741376_ChIP-Seq_ESCs_Human0.85226943
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84383030
178EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83143336
179FLI1_27457419_Chip-Seq_LIVER_Mouse0.82713728
180NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82531935
181REST_18959480_ChIP-ChIP_MESCs_Mouse0.81986372
182SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81609379
183RUNX2_22187159_ChIP-Seq_PCA_Human0.80872527
184MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80793363
185OCT1_27270436_Chip-Seq_PROSTATE_Human0.80703756
186CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80348175
187POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80167345
188SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78369165
189ESR1_21235772_ChIP-Seq_MCF-7_Human0.78070091
190ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77129070
191SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76339394
192SOX17_20123909_ChIP-Seq_XEN_Mouse0.75859951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell7.11682092
2MP0003693_abnormal_embryo_hatching5.54823659
3MP0002822_catalepsy5.16807949
4MP0008961_abnormal_basal_metabolism4.93762273
5MP0003878_abnormal_ear_physiology4.63963676
6MP0005377_hearing/vestibular/ear_phenot4.63963676
7MP0008260_abnormal_autophagy3.75929528
8MP0003656_abnormal_erythrocyte_physiolo3.62576131
9MP0003111_abnormal_nucleus_morphology3.59007604
10MP0003718_maternal_effect3.43171034
11MP0001485_abnormal_pinna_reflex3.42179723
12MP0003868_abnormal_feces_composition3.33088501
13MP0003123_paternal_imprinting3.25946252
14MP0004957_abnormal_blastocyst_morpholog3.25428134
15MP0002234_abnormal_pharynx_morphology2.89489492
16MP0000678_abnormal_parathyroid_gland2.63429937
17MP0002735_abnormal_chemical_nociception2.60988147
18MP0000026_abnormal_inner_ear2.58628157
19MP0001968_abnormal_touch/_nociception2.50579093
20MP0003077_abnormal_cell_cycle2.44159395
21MP0003763_abnormal_thymus_physiology2.41222460
22* MP0001963_abnormal_hearing_physiology2.37879031
23MP0009278_abnormal_bone_marrow2.37328591
24MP0003938_abnormal_ear_development2.35104367
25MP0010094_abnormal_chromosome_stability2.21109331
26MP0004782_abnormal_surfactant_physiolog2.16412892
27MP0004808_abnormal_hematopoietic_stem2.09913893
28MP0003724_increased_susceptibility_to2.06931278
29MP0005646_abnormal_pituitary_gland2.02360441
30MP0004885_abnormal_endolymph2.00446027
31MP0003880_abnormal_central_pattern1.92387486
32MP0001730_embryonic_growth_arrest1.84870190
33MP0001800_abnormal_humoral_immune1.83381555
34MP0003941_abnormal_skin_development1.80604638
35MP0009840_abnormal_foam_cell1.75299669
36MP0002249_abnormal_larynx_morphology1.74292380
37MP0003183_abnormal_peptide_metabolism1.72885058
38MP0002733_abnormal_thermal_nociception1.71531479
39MP0004859_abnormal_synaptic_plasticity1.70266316
40MP0008932_abnormal_embryonic_tissue1.69784647
41MP0005671_abnormal_response_to1.69652363
42MP0005248_abnormal_Harderian_gland1.67395226
43MP0005387_immune_system_phenotype1.66816059
44MP0001790_abnormal_immune_system1.66816059
45MP0008058_abnormal_DNA_repair1.66657499
46MP0005000_abnormal_immune_tolerance1.61969477
47MP0001835_abnormal_antigen_presentation1.55269430
48MP0001529_abnormal_vocalization1.54993502
49MP0008007_abnormal_cellular_replicative1.53727793
50MP0008057_abnormal_DNA_replication1.51933624
51MP0001664_abnormal_digestion1.48853691
52MP0000681_abnormal_thyroid_gland1.45359683
53MP0008995_early_reproductive_senescence1.44713165
54MP0003436_decreased_susceptibility_to1.43122127
55MP0001672_abnormal_embryogenesis/_devel1.42334638
56MP0005380_embryogenesis_phenotype1.42334638
57MP0002405_respiratory_system_inflammati1.40955817
58MP0002653_abnormal_ependyma_morphology1.40780815
59MP0003786_premature_aging1.37648273
60MP0001986_abnormal_taste_sensitivity1.35300220
61MP0000534_abnormal_ureter_morphology1.32712728
62MP0001819_abnormal_immune_cell1.32574044
63MP0008569_lethality_at_weaning1.32191219
64MP0002420_abnormal_adaptive_immunity1.32125074
65MP0000920_abnormal_myelination1.31960264
66MP0001919_abnormal_reproductive_system1.31811801
67MP0001501_abnormal_sleep_pattern1.31692547
68MP0009745_abnormal_behavioral_response1.31311809
69MP0002452_abnormal_antigen_presenting1.31296240
70MP0000350_abnormal_cell_proliferation1.28682975
71MP0006054_spinal_hemorrhage1.28298812
72MP0001970_abnormal_pain_threshold1.27695387
73MP0002102_abnormal_ear_morphology1.27248493
74MP0008877_abnormal_DNA_methylation1.26448992
75MP0002723_abnormal_immune_serum1.22036741
76MP0004264_abnormal_extraembryonic_tissu1.21417749
77MP0003984_embryonic_growth_retardation1.19138585
78MP0005451_abnormal_body_composition1.17353752
79MP0001697_abnormal_embryo_size1.16410626
80MP0002088_abnormal_embryonic_growth/wei1.16373811
81MP0002419_abnormal_innate_immunity1.16139864
82MP0000383_abnormal_hair_follicle1.15460576
83MP0004142_abnormal_muscle_tone1.13297924
84MP0003567_abnormal_fetal_cardiomyocyte1.12873295
85MP0002085_abnormal_embryonic_tissue1.12655782
86MP0002148_abnormal_hypersensitivity_rea1.11491176
87MP0003828_pulmonary_edema1.11455767
88MP0000465_gastrointestinal_hemorrhage1.11296713
89MP0001849_ear_inflammation1.10509373
90MP0009765_abnormal_xenobiotic_induced1.10463167
91MP0002398_abnormal_bone_marrow1.10383494
92MP0000703_abnormal_thymus_morphology1.09622050
93MP0000490_abnormal_crypts_of1.09084586
94MP0000689_abnormal_spleen_morphology1.08980624
95MP0000516_abnormal_urinary_system1.07904674
96MP0005367_renal/urinary_system_phenotyp1.07904674
97MP0005167_abnormal_blood-brain_barrier1.07555603
98MP0000716_abnormal_immune_system1.07375138
99MP0003315_abnormal_perineum_morphology1.05830760
100MP0002210_abnormal_sex_determination1.05730341
101MP0009053_abnormal_anal_canal1.05379264
102MP0005395_other_phenotype1.04405419
103MP0009764_decreased_sensitivity_to1.04260154
104MP0001542_abnormal_bone_strength1.04069809
105MP0002080_prenatal_lethality1.03911959
106MP0010678_abnormal_skin_adnexa1.02527388
107MP0000428_abnormal_craniofacial_morphol1.01874199
108MP0002736_abnormal_nociception_after1.00905507
109MP0003866_abnormal_defecation1.00495322
110MP0005025_abnormal_response_to1.00417189
111MP0003119_abnormal_digestive_system0.98648137
112MP0004484_altered_response_of0.97468775
113MP0003937_abnormal_limbs/digits/tail_de0.96666331
114MP0003221_abnormal_cardiomyocyte_apopto0.96045019
115MP0003942_abnormal_urinary_system0.94535283
116MP0002233_abnormal_nose_morphology0.94166834
117MP0001764_abnormal_homeostasis0.93584747
118MP0009333_abnormal_splenocyte_physiolog0.93167228
119MP0002876_abnormal_thyroid_physiology0.93043057
120MP0001851_eye_inflammation0.92873458
121MP0002722_abnormal_immune_system0.92384955
122MP0005508_abnormal_skeleton_morphology0.90971059
123MP0008872_abnormal_physiological_respon0.90054965
124MP0010030_abnormal_orbit_morphology0.89799050
125MP0002086_abnormal_extraembryonic_tissu0.89712581
126MP0001873_stomach_inflammation0.89384784
127MP0009785_altered_susceptibility_to0.89037168
128MP0002063_abnormal_learning/memory/cond0.88988322
129MP0001929_abnormal_gametogenesis0.88903888
130MP0002084_abnormal_developmental_patter0.88851232
131MP0001145_abnormal_male_reproductive0.88437489
132MP0004019_abnormal_vitamin_homeostasis0.85869965
133MP0001661_extended_life_span0.85446018
134MP0004215_abnormal_myocardial_fiber0.82979343
135MP0004924_abnormal_behavior0.82974840
136MP0005386_behavior/neurological_phenoty0.82974840
137MP0006082_CNS_inflammation0.82501915
138MP0000653_abnormal_sex_gland0.82258938
139MP0003633_abnormal_nervous_system0.81957642
140MP0001845_abnormal_inflammatory_respons0.81874992
141MP0001286_abnormal_eye_development0.81685429
142MP0005464_abnormal_platelet_physiology0.79043260
143MP0002009_preneoplasia0.78960265
144MP0003635_abnormal_synaptic_transmissio0.78794753
145MP0002429_abnormal_blood_cell0.78291984
146MP0002111_abnormal_tail_morphology0.78122241
147MP0002064_seizures0.77572496
148MP0005551_abnormal_eye_electrophysiolog0.77356217
149MP0002572_abnormal_emotion/affect_behav0.76224104
150MP0004084_abnormal_cardiac_muscle0.73888186
151MP0002138_abnormal_hepatobiliary_system0.73492033
152MP0002277_abnormal_respiratory_mucosa0.73267579
153MP0002163_abnormal_gland_morphology0.73106449
154MP0003755_abnormal_palate_morphology0.72433844
155MP0000647_abnormal_sebaceous_gland0.71595038
156MP0008874_decreased_physiological_sensi0.69895810
157MP0000579_abnormal_nail_morphology0.69732761
158MP0005645_abnormal_hypothalamus_physiol0.68434511
159MP0002396_abnormal_hematopoietic_system0.67705522
160MP0005166_decreased_susceptibility_to0.65562481
161MP0009672_abnormal_birth_weight0.65524428
162MP0001293_anophthalmia0.65066108
163MP0010307_abnormal_tumor_latency0.64746586
164MP0000049_abnormal_middle_ear0.64560323
165MP0006292_abnormal_olfactory_placode0.63740241
166MP0000566_synostosis0.63734352
167MP0005389_reproductive_system_phenotype0.63107283
168MP0000750_abnormal_muscle_regeneration0.62618699
169MP0000432_abnormal_head_morphology0.62137608
170MP0004197_abnormal_fetal_growth/weight/0.61392494
171MP0010155_abnormal_intestine_physiology0.60894536
172MP0001486_abnormal_startle_reflex0.60641749
173MP0001545_abnormal_hematopoietic_system0.59363404
174MP0005397_hematopoietic_system_phenotyp0.59363404
175MP0003699_abnormal_female_reproductive0.59071696
176MP0002161_abnormal_fertility/fecundity0.58882966
177MP0001533_abnormal_skeleton_physiology0.58678971
178MP0002557_abnormal_social/conspecific_i0.57874766
179MP0005535_abnormal_body_temperature0.57776347
180MP0009250_abnormal_appendicular_skeleto0.57379260
181MP0002067_abnormal_sensory_capabilities0.56914359
182MP0005408_hypopigmentation0.56756292
183MP0000537_abnormal_urethra_morphology0.55665557
184MP0004742_abnormal_vestibular_system0.55454714
185MP0001905_abnormal_dopamine_level0.55448030
186MP0001756_abnormal_urination0.54865054
187MP0006138_congestive_heart_failure0.54571166
188MP0001346_abnormal_lacrimal_gland0.54560758
189MP0000613_abnormal_salivary_gland0.54200714
190MP0002092_abnormal_eye_morphology0.53951105

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.62106935
2Irregular epiphyses (HP:0010582)6.34760492
3Abnormality of the renal collecting system (HP:0004742)5.21135854
4Absent rod-and cone-mediated responses on ERG (HP:0007688)5.07919757
5Hyperglycinemia (HP:0002154)5.01666234
6Hyperglycinuria (HP:0003108)4.83634952
7Short 1st metacarpal (HP:0010034)4.79291606
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.79291606
9Ketosis (HP:0001946)4.62758092
10Birth length less than 3rd percentile (HP:0003561)4.33697449
11Vitreoretinal degeneration (HP:0000655)4.33088233
12Abnormality of the common coagulation pathway (HP:0010990)4.27617297
13Stomatitis (HP:0010280)4.27230273
14Abnormality of the 1st metacarpal (HP:0010009)4.24228074
15Breast hypoplasia (HP:0003187)4.21626928
16Small epiphyses (HP:0010585)4.12947964
17Severe Myopia (HP:0011003)4.10485838
18Impulsivity (HP:0100710)4.06992996
19Cerebral hypomyelination (HP:0006808)4.01843118
20Thyroid-stimulating hormone excess (HP:0002925)3.91639193
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.86280925
22Absent epiphyses (HP:0010577)3.86280925
23Genu varum (HP:0002970)3.85915453
24Myositis (HP:0100614)3.84312224
25Menorrhagia (HP:0000132)3.76954971
26Abnormality of serine family amino acid metabolism (HP:0010894)3.73825108
27Abnormality of glycine metabolism (HP:0010895)3.73825108
28Abnormality of the intrinsic pathway (HP:0010989)3.73111271
29Large for gestational age (HP:0001520)3.58557466
30Carpal bone hypoplasia (HP:0001498)3.54980003
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.54917423
32Fused cervical vertebrae (HP:0002949)3.50104564
33Glossoptosis (HP:0000162)3.39779125
34Abnormal rod and cone electroretinograms (HP:0008323)3.35068876
35Hypoplastic ischia (HP:0003175)3.34712630
36Rough bone trabeculation (HP:0100670)3.27520340
37Oral leukoplakia (HP:0002745)3.26855860
38Short phalanx of the thumb (HP:0009660)3.25254958
39Patellar aplasia (HP:0006443)3.21203109
40Flattened epiphyses (HP:0003071)3.18328296
41Panhypogammaglobulinemia (HP:0003139)3.17857943
42Pancreatitis (HP:0001733)3.14180032
43Aplasia/Hypoplasia of the patella (HP:0006498)3.13365456
44Cerebral edema (HP:0002181)3.09191106
45Elevated erythrocyte sedimentation rate (HP:0003565)3.07145911
46Enlarged epiphyses (HP:0010580)3.04041071
47Mild short stature (HP:0003502)3.03972180
48Papilledema (HP:0001085)2.98418126
49Abnormality of the umbilical cord (HP:0010881)2.97593608
50Mixed hearing impairment (HP:0000410)2.97028815
51Limb hypertonia (HP:0002509)2.91770484
52Prolonged neonatal jaundice (HP:0006579)2.85482143
53Ureteral duplication (HP:0000073)2.82789355
54Orchitis (HP:0100796)2.79086653
55Abnormality of the ischium (HP:0003174)2.78899072
56Delayed epiphyseal ossification (HP:0002663)2.77999231
57Duplicated collecting system (HP:0000081)2.75464008
58Methylmalonic acidemia (HP:0002912)2.74258877
59Gout (HP:0001997)2.70775728
60Neonatal respiratory distress (HP:0002643)2.69524920
61Abnormal pancreas size (HP:0012094)2.67948363
62Entropion (HP:0000621)2.66999148
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.64888266
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.62980547
65Epistaxis (HP:0000421)2.61874004
66Constricted visual fields (HP:0001133)2.54802699
67Premature rupture of membranes (HP:0001788)2.53186727
68CNS hypomyelination (HP:0003429)2.52450464
69Abnormality of the labia minora (HP:0012880)2.51494942
70Recurrent fungal infections (HP:0002841)2.51460078
71Episodic fever (HP:0001954)2.50196060
72Encephalitis (HP:0002383)2.49147755
73Absent/shortened dynein arms (HP:0200106)2.46439337
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.46439337
75Abnormal trabecular bone morphology (HP:0100671)2.45566234
76Abnormality of the aortic arch (HP:0012303)2.45174520
77Abnormality of glycolipid metabolism (HP:0010969)2.44740789
78Abnormality of liposaccharide metabolism (HP:0010968)2.44740789
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.44740789
80Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.43945828
81Vertebral hypoplasia (HP:0008417)2.43945828
82J-shaped sella turcica (HP:0002680)2.43838781
83Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.43378198
84Muscle fiber splitting (HP:0003555)2.40976240
85Patent foramen ovale (HP:0001655)2.39541623
86Broad alveolar ridges (HP:0000187)2.39179853
87Attenuation of retinal blood vessels (HP:0007843)2.38225287
88Retrobulbar optic neuritis (HP:0100654)2.38196193
89Optic neuritis (HP:0100653)2.38196193
90Abnormality of serum amino acid levels (HP:0003112)2.37750421
91Oligodactyly (hands) (HP:0001180)2.34534755
92Congenital, generalized hypertrichosis (HP:0004540)2.32014677
93Eczematoid dermatitis (HP:0000976)2.31456637
94Sparse eyelashes (HP:0000653)2.30574965
95Abnormalities of placenta or umbilical cord (HP:0001194)2.28152610
96Multiple enchondromatosis (HP:0005701)2.26930719
97Alopecia of scalp (HP:0002293)2.25421020
98Mediastinal lymphadenopathy (HP:0100721)2.24970269
99Stenosis of the external auditory canal (HP:0000402)2.24945061
100Morphological abnormality of the inner ear (HP:0011390)2.24758645
101Focal motor seizures (HP:0011153)2.24231165
102Microretrognathia (HP:0000308)2.23217969
103Widely spaced teeth (HP:0000687)2.22637978
104Death in infancy (HP:0001522)2.21581401
105Pancreatic islet-cell hyperplasia (HP:0004510)2.21352287
106Medial flaring of the eyebrow (HP:0010747)2.21183103
107Bundle branch block (HP:0011710)2.20088264
108Chronic mucocutaneous candidiasis (HP:0002728)2.18641492
109Recurrent cutaneous fungal infections (HP:0011370)2.18641492
110Bell-shaped thorax (HP:0001591)2.17528115
111Oligodactyly (HP:0012165)2.16892013
112Hypoplasia of the thymus (HP:0000778)2.16195716
113Oligodontia (HP:0000677)2.16162047
114Progressive muscle weakness (HP:0003323)2.16056349
115Secondary amenorrhea (HP:0000869)2.15590747
116Atrioventricular block (HP:0001678)2.15368657
117Abnormal spermatogenesis (HP:0008669)2.15335978
118Split foot (HP:0001839)2.14108132
119Intestinal atresia (HP:0011100)2.12016163
120Meningitis (HP:0001287)2.11166683
121Abnormality of the vertebral endplates (HP:0005106)2.11110123
122Agitation (HP:0000713)2.10203321
123Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08869766
124Short hallux (HP:0010109)2.08626878
125Gastrointestinal infarctions (HP:0005244)2.05201410
126Delusions (HP:0000746)2.04909554
127Ventricular fibrillation (HP:0001663)2.04548040
128Abnormality of the epiphysis of the femoral head (HP:0010574)2.03583935
129Synostosis of carpal bones (HP:0005048)2.03414620
130Choroideremia (HP:0001139)2.03147907
131Methylmalonic aciduria (HP:0012120)2.01942004
132Stillbirth (HP:0003826)2.01015899
133Recurrent bacterial skin infections (HP:0005406)2.00625791
134Tetraplegia (HP:0002445)2.00408621
135Keratoconjunctivitis sicca (HP:0001097)2.00022259
136Osteoarthritis (HP:0002758)1.98467208
137Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.98304557
138Abnormality of femoral epiphyses (HP:0006499)1.98304557
139Aplasia/Hypoplasia of the hallux (HP:0008362)1.98197146
140Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98045675
141Breast aplasia (HP:0100783)1.97372891
142Tented upper lip vermilion (HP:0010804)1.95499161
143Polyphagia (HP:0002591)1.94430516
144Increased hepatocellular lipid droplets (HP:0006565)1.93931770
145Long foot (HP:0001833)1.93810438
146Capillary hemangiomas (HP:0005306)1.93558712
147Abnormality of the distal phalanges of the toes (HP:0010182)1.92994342
148Abnormality of the prostate (HP:0008775)1.92651019
149Hypoproteinemia (HP:0003075)1.92631518
150Aplasia/Hypoplasia of the breasts (HP:0010311)1.91052282
151Chronic obstructive pulmonary disease (HP:0006510)1.91008586
152Obstructive lung disease (HP:0006536)1.91008586
153Mesangial abnormality (HP:0001966)1.90810024
154Abnormality of the pubic bones (HP:0003172)1.90726693
155Aplasia/hypoplasia of the uterus (HP:0008684)1.90534509
156Agammaglobulinemia (HP:0004432)1.90072009
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87679997
158Azoospermia (HP:0000027)1.86992209
159Increased intramyocellular lipid droplets (HP:0012240)1.86825965
160Aplasia involving forearm bones (HP:0009822)1.86401393
161Absent forearm bone (HP:0003953)1.86401393
162Abnormality of the femoral head (HP:0003368)1.86388399
163Absent radius (HP:0003974)1.85767797
164Restlessness (HP:0000711)1.85617757
165Bicornuate uterus (HP:0000813)1.84830490
166Congenital malformation of the right heart (HP:0011723)1.83632664
167Double outlet right ventricle (HP:0001719)1.83632664
168Premature ovarian failure (HP:0008209)1.83112503
169Papillary thyroid carcinoma (HP:0002895)1.82840788
170Hypochromic microcytic anemia (HP:0004840)1.81613383
171Adrenal hypoplasia (HP:0000835)1.80721851
172Optic disc pallor (HP:0000543)1.79823647
173Severe combined immunodeficiency (HP:0004430)1.79397274
174Vertebral clefting (HP:0008428)1.78914438
175Brittle hair (HP:0002299)1.77866149
176Volvulus (HP:0002580)1.77105961
177Keratoconjunctivitis (HP:0001096)1.77071147
178Carpal synostosis (HP:0009702)1.76184133
179Recurrent abscess formation (HP:0002722)1.75260131
180Abnormality of T cells (HP:0002843)1.73957087
181Dyskinesia (HP:0100660)1.73547071
182Short nail (HP:0001799)1.73046452
183Pancreatic fibrosis (HP:0100732)1.72938215
184Abnormality of the anterior horn cell (HP:0006802)1.72782430
185Degeneration of anterior horn cells (HP:0002398)1.72782430
186Facial hemangioma (HP:0000329)1.72750719
187Ureteral stenosis (HP:0000071)1.72296766
188Spontaneous hematomas (HP:0007420)1.71946313
189Cellulitis (HP:0100658)1.70472072
190Renal Fanconi syndrome (HP:0001994)1.69463001
191IgG deficiency (HP:0004315)1.68155408
192Morphological abnormality of the middle ear (HP:0008609)1.65467585
193Lethargy (HP:0001254)1.65341753
194Recurrent skin infections (HP:0001581)1.64063599
195Granulocytopenia (HP:0001913)1.63292442
196Increased muscle lipid content (HP:0009058)1.61739351
197Lip pit (HP:0100267)1.60606536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.15398485
2DDR25.11667391
3WEE14.58768730
4TSSK62.97609799
5AKT32.97186099
6EPHA22.61850285
7NEK22.55117178
8EIF2AK12.49787313
9CCNB12.47657240
10NME22.33978836
11BRSK22.33804854
12PNCK2.32490188
13PLK32.29694822
14MKNK22.21536960
15SRPK12.17562500
16STK162.16065053
17BCKDK14.2985338
18DYRK31.99581415
19PLK41.98309133
20TTK1.91565576
21MAP4K11.90680796
22EIF2AK31.88268008
23STK38L1.80415132
24NEK11.78957098
25PLK11.76430516
26LATS21.76308142
27ADRBK21.73502488
28ARAF1.73036886
29LATS11.72690110
30PDK31.67262435
31PDK41.67262435
32TXK1.65561789
33TAOK31.63511926
34STK31.61144886
35BRSK11.57770476
36MKNK11.53747202
37MAPK131.51375254
38ERN11.42238331
39PDK21.41580115
40NME11.30048105
41BRAF1.22852013
42AURKB1.20796826
43IRAK31.20610461
44PRKG21.18615798
45ACVR1B1.17403576
46TGFBR21.16060029
47CHEK21.13845995
48MAP4K21.12181894
49PIM21.12163509
50PRKCI1.06433566
51NUAK11.03245163
52FES1.02160412
53TESK21.00544883
54ALK0.97488625
55ZAK0.96504851
56MAP3K60.95469453
57ZAP700.91931616
58AURKA0.90148257
59TNK20.86919485
60STK240.86918994
61SIK20.86523822
62MARK30.83204899
63FRK0.79654915
64MAP2K60.77496048
65CHEK10.74151239
66CSNK1G10.73931004
67EPHA30.72163398
68CSNK1G30.71500252
69IKBKE0.70863969
70ITK0.68801045
71CDK40.68604061
72SYK0.68374042
73BTK0.67607967
74WNK30.66888971
75EPHA40.66447395
76CAMKK20.65278708
77PINK10.64776975
78GRK60.62852401
79MELK0.62562438
80ABL10.60797836
81HCK0.60554034
82TEC0.60185250
83CSNK1E0.59511067
84KIT0.59477569
85CSK0.58800153
86EIF2AK20.57695687
87LCK0.57496869
88EPHB10.57071259
89CDC70.56574054
90CSNK1G20.55257648
91JAK30.55054770
92PRKD20.54771276
93MAP3K110.54341800
94MAP3K80.54025627
95NTRK30.53774129
96PAK10.52974145
97RIPK40.52509922
98CDK70.52212675
99PLK20.51494184
100CSNK1A1L0.51222271
101MAP2K20.49529717
102NTRK20.49389600
103CDK30.49052353
104CDK20.49008706
105PRKCG0.46877949
106ADRBK10.46603286
107CSNK2A20.46026568
108CHUK0.44752235
109RPS6KA40.44330303
110IKBKB0.43963764
111CSNK2A10.43800955
112SIK30.43477250
113PIM10.42802416
114STK390.42778850
115GRK10.42356802
116CDK60.41786877
117MAP2K30.41758286
118DYRK20.41424170
119PRKCQ0.40537420
120PRKAA10.40522997
121IRAK40.40453039
122PRKCE0.39790344
123CLK10.39621067
124PRKCZ0.39539352
125MATK0.38718559
126ERBB30.38106016
127BLK0.37812924
128CASK0.37547820
129MAP3K30.35971887
130TYK20.34990761
131PRKCD0.34841910
132INSR0.34798147
133JAK10.34668461
134CAMK40.34362425
135CDK10.33939643
136VRK10.33394239
137MAP3K90.33108707
138MAPKAPK20.32013339
139RAF10.31819257
140LYN0.31213910
141CSNK1A10.30745395
142STK110.30745222
143PAK40.30526497
144PRKCH0.29206132
145MAP3K100.27557909
146JAK20.27390307
147NEK60.27329098
148MST40.27308692
149OXSR10.26957513
150MAPK70.26756220
151FYN0.26745979
152CAMK2G0.25972385
153CAMKK10.25864408
154SGK10.25534108
155NEK90.25293286
156TBK10.25134153
157RET0.24379473
158STK40.23414901
159ATR0.22604608
160MAP2K40.22512013
161STK380.22151102
162PASK0.21977596
163DYRK1A0.21941347
164PRKCB0.21782921
165BMPR20.21478144
166CSF1R0.20766112
167DYRK1B0.20455898
168SGK20.20328996
169MAP3K10.20178230
170TRIB30.20050440
171ABL20.19568789
172NLK0.19240959
173FLT30.18895281
174MAPK30.18868285
175MAPK100.17168131
176GRK70.16683560
177MARK10.16233412
178PAK60.13953233
179CDK190.13684215
180ATM0.13138644
181TAOK10.12818900
182MAP3K50.11955994

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.06793099
2RNA polymerase_Homo sapiens_hsa030205.15156474
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.59168080
4RNA transport_Homo sapiens_hsa030133.47374932
5Proteasome_Homo sapiens_hsa030503.47298088
6Propanoate metabolism_Homo sapiens_hsa006403.21032630
7Regulation of autophagy_Homo sapiens_hsa041402.96917673
8Primary immunodeficiency_Homo sapiens_hsa053402.90614871
9Cell cycle_Homo sapiens_hsa041102.54299294
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.52193905
11Basal transcription factors_Homo sapiens_hsa030222.49480148
12Pyrimidine metabolism_Homo sapiens_hsa002402.39478403
13Spliceosome_Homo sapiens_hsa030402.17737180
14Graft-versus-host disease_Homo sapiens_hsa053322.03318279
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02135047
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98276816
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96061338
18Allograft rejection_Homo sapiens_hsa053301.92536941
19Autoimmune thyroid disease_Homo sapiens_hsa053201.91595042
20Vitamin digestion and absorption_Homo sapiens_hsa049771.87262672
21Olfactory transduction_Homo sapiens_hsa047401.86134174
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.81436264
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80885516
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75376885
25Starch and sucrose metabolism_Homo sapiens_hsa005001.70880723
26DNA replication_Homo sapiens_hsa030301.67773066
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67316370
28Folate biosynthesis_Homo sapiens_hsa007901.67000741
29Nucleotide excision repair_Homo sapiens_hsa034201.64536831
30Purine metabolism_Homo sapiens_hsa002301.64177730
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62504893
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60792156
33p53 signaling pathway_Homo sapiens_hsa041151.57051233
34Asthma_Homo sapiens_hsa053101.51454369
35Ribosome_Homo sapiens_hsa030101.47933107
36Salivary secretion_Homo sapiens_hsa049701.47126087
37Oocyte meiosis_Homo sapiens_hsa041141.47029011
38Pentose phosphate pathway_Homo sapiens_hsa000301.45397106
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44369207
40Homologous recombination_Homo sapiens_hsa034401.43181198
41Type I diabetes mellitus_Homo sapiens_hsa049401.41275448
42T cell receptor signaling pathway_Homo sapiens_hsa046601.40341371
43Osteoclast differentiation_Homo sapiens_hsa043801.37183762
44Staphylococcus aureus infection_Homo sapiens_hsa051501.30881127
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30317893
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28501361
47Renin secretion_Homo sapiens_hsa049241.26453558
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26301272
49Hippo signaling pathway_Homo sapiens_hsa043901.21992630
50Morphine addiction_Homo sapiens_hsa050321.20478194
51Base excision repair_Homo sapiens_hsa034101.19793322
52Mismatch repair_Homo sapiens_hsa034301.19637042
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.17657395
54Serotonergic synapse_Homo sapiens_hsa047261.17311721
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16219308
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.15060680
57B cell receptor signaling pathway_Homo sapiens_hsa046621.13964293
58Platelet activation_Homo sapiens_hsa046111.13048359
59mRNA surveillance pathway_Homo sapiens_hsa030151.12541352
60Protein digestion and absorption_Homo sapiens_hsa049741.12469242
61Calcium signaling pathway_Homo sapiens_hsa040201.12350317
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11124366
63Phototransduction_Homo sapiens_hsa047441.09847695
64Circadian entrainment_Homo sapiens_hsa047131.09587856
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09477609
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09086327
67Hematopoietic cell lineage_Homo sapiens_hsa046401.08753775
68Leishmaniasis_Homo sapiens_hsa051401.07790182
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07717255
70Taste transduction_Homo sapiens_hsa047421.07550237
71Tuberculosis_Homo sapiens_hsa051521.04355258
72Circadian rhythm_Homo sapiens_hsa047101.03060611
73N-Glycan biosynthesis_Homo sapiens_hsa005101.02107063
74Epstein-Barr virus infection_Homo sapiens_hsa051691.01066751
75Nicotine addiction_Homo sapiens_hsa050331.00799042
76cAMP signaling pathway_Homo sapiens_hsa040240.97827443
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94920423
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89795957
79Long-term depression_Homo sapiens_hsa047300.87840972
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83482641
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83276152
82Viral myocarditis_Homo sapiens_hsa054160.83155299
83Histidine metabolism_Homo sapiens_hsa003400.82269143
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79997450
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.79282701
86Biosynthesis of amino acids_Homo sapiens_hsa012300.78964069
87Fanconi anemia pathway_Homo sapiens_hsa034600.78775481
88RNA degradation_Homo sapiens_hsa030180.78751024
89beta-Alanine metabolism_Homo sapiens_hsa004100.78022906
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77911889
91Arginine and proline metabolism_Homo sapiens_hsa003300.77816027
92African trypanosomiasis_Homo sapiens_hsa051430.76313990
93Fructose and mannose metabolism_Homo sapiens_hsa000510.76256600
94Legionellosis_Homo sapiens_hsa051340.76129985
95TGF-beta signaling pathway_Homo sapiens_hsa043500.73787917
96ABC transporters_Homo sapiens_hsa020100.73254797
97Measles_Homo sapiens_hsa051620.72538856
98Malaria_Homo sapiens_hsa051440.72140548
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71129772
100Linoleic acid metabolism_Homo sapiens_hsa005910.71035997
101Chemokine signaling pathway_Homo sapiens_hsa040620.70046346
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69542267
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69424149
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66194334
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63930571
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.63340961
107Hedgehog signaling pathway_Homo sapiens_hsa043400.60590162
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60558536
109VEGF signaling pathway_Homo sapiens_hsa043700.60354728
110Tight junction_Homo sapiens_hsa045300.59982949
111Toxoplasmosis_Homo sapiens_hsa051450.58385672
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.57384724
113Glutamatergic synapse_Homo sapiens_hsa047240.57138181
114Mineral absorption_Homo sapiens_hsa049780.57065820
115Basal cell carcinoma_Homo sapiens_hsa052170.56971380
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.56555022
117Cholinergic synapse_Homo sapiens_hsa047250.55411380
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54547562
119Fat digestion and absorption_Homo sapiens_hsa049750.53888162
120Rheumatoid arthritis_Homo sapiens_hsa053230.53261545
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52202080
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51891329
123Amphetamine addiction_Homo sapiens_hsa050310.51553808
124TNF signaling pathway_Homo sapiens_hsa046680.51254582
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50732988
126Renin-angiotensin system_Homo sapiens_hsa046140.50500780
127Retinol metabolism_Homo sapiens_hsa008300.50221974
128Sphingolipid metabolism_Homo sapiens_hsa006000.50148646
129mTOR signaling pathway_Homo sapiens_hsa041500.49269111
130Glutathione metabolism_Homo sapiens_hsa004800.49063105
131Wnt signaling pathway_Homo sapiens_hsa043100.48125153
132Arachidonic acid metabolism_Homo sapiens_hsa005900.45856195
133Influenza A_Homo sapiens_hsa051640.45675485
134Prolactin signaling pathway_Homo sapiens_hsa049170.44705546
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44141561
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44086309
137Endocytosis_Homo sapiens_hsa041440.44030219
138Herpes simplex infection_Homo sapiens_hsa051680.43802148
139Cocaine addiction_Homo sapiens_hsa050300.43785352
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43716554
141Chemical carcinogenesis_Homo sapiens_hsa052040.42940605
142Ether lipid metabolism_Homo sapiens_hsa005650.41820564
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.41520576
144Metabolic pathways_Homo sapiens_hsa011000.41404181
145Selenocompound metabolism_Homo sapiens_hsa004500.39854567
146FoxO signaling pathway_Homo sapiens_hsa040680.37664289
147ECM-receptor interaction_Homo sapiens_hsa045120.36869434
148Dorso-ventral axis formation_Homo sapiens_hsa043200.36569359
149Dopaminergic synapse_Homo sapiens_hsa047280.36246786
150Renal cell carcinoma_Homo sapiens_hsa052110.35686995
151Phenylalanine metabolism_Homo sapiens_hsa003600.35459076
152Acute myeloid leukemia_Homo sapiens_hsa052210.33945043
153Peroxisome_Homo sapiens_hsa041460.33585218
154Antigen processing and presentation_Homo sapiens_hsa046120.33005787
155Sulfur relay system_Homo sapiens_hsa041220.31681134
1562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30707793
157Intestinal immune network for IgA production_Homo sapiens_hsa046720.30496530
158Carbon metabolism_Homo sapiens_hsa012000.30464984
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30261993
160HTLV-I infection_Homo sapiens_hsa051660.24705547
161Thyroid cancer_Homo sapiens_hsa052160.24461595
162Lysosome_Homo sapiens_hsa041420.24428397
163Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24007637
164Glycerolipid metabolism_Homo sapiens_hsa005610.21999289
165Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21343557
166Collecting duct acid secretion_Homo sapiens_hsa049660.20336294
167Galactose metabolism_Homo sapiens_hsa000520.19842806
168Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19542867
169Inositol phosphate metabolism_Homo sapiens_hsa005620.18761661
170Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15985993
171Prostate cancer_Homo sapiens_hsa052150.15962277
172Small cell lung cancer_Homo sapiens_hsa052220.13418626
173MicroRNAs in cancer_Homo sapiens_hsa052060.12357488
174Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12247631
175Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10035058
176Fatty acid biosynthesis_Homo sapiens_hsa000610.08206334
177Viral carcinogenesis_Homo sapiens_hsa052030.07478302
178Melanoma_Homo sapiens_hsa052180.05908322
179Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05246565
180Butanoate metabolism_Homo sapiens_hsa006500.02111501
181Pathways in cancer_Homo sapiens_hsa052000.00345770
182Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0150196
183Choline metabolism in cancer_Homo sapiens_hsa05231-0.0092500

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