OASL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* type I interferon signaling pathway (GO:0060337)6.01387357
2* cellular response to type I interferon (GO:0071357)6.01387357
3* response to type I interferon (GO:0034340)5.93325104
4regulation of vitamin D biosynthetic process (GO:0060556)5.16210424
5regulation of interferon-alpha production (GO:0032647)5.09763205
6regulation of chronic inflammatory response (GO:0002676)5.07948168
7regulation of T-helper 1 cell differentiation (GO:0045625)5.00297191
8cellular response to interferon-alpha (GO:0035457)4.81543261
9* negative regulation of viral genome replication (GO:0045071)4.74852252
10negative regulation of interleukin-12 production (GO:0032695)4.72503300
11positive regulation of interferon-alpha production (GO:0032727)4.48281301
12response to interferon-alpha (GO:0035455)4.45888306
13response to peptidoglycan (GO:0032494)4.45345746
14regulation of cytokine secretion involved in immune response (GO:0002739)4.20111173
15lipopolysaccharide-mediated signaling pathway (GO:0031663)4.18392294
16regulation of vitamin metabolic process (GO:0030656)4.10570809
17positive regulation of type 2 immune response (GO:0002830)3.94165054
18positive regulation of chemokine biosynthetic process (GO:0045080)3.92882155
19positive regulation of heat generation (GO:0031652)3.89341097
20negative regulation of cytokine production involved in immune response (GO:0002719)3.84852493
21macrophage activation involved in immune response (GO:0002281)3.84009089
22NIK/NF-kappaB signaling (GO:0038061)3.81419670
23regulation of fever generation (GO:0031620)3.78159457
24regulation of chemokine biosynthetic process (GO:0045073)3.78023977
25regulation of type I interferon-mediated signaling pathway (GO:0060338)3.73110981
26positive regulation of gamma-delta T cell activation (GO:0046645)3.70781026
27* interferon-gamma-mediated signaling pathway (GO:0060333)3.67444331
28response to interferon-beta (GO:0035456)3.61895078
29immunoglobulin mediated immune response (GO:0016064)3.58834082
30myeloid dendritic cell differentiation (GO:0043011)3.54476123
31positive regulation of interferon-beta production (GO:0032728)3.53539262
32defense response to protozoan (GO:0042832)3.53462518
33cellular response to exogenous dsRNA (GO:0071360)3.53242867
34branching involved in labyrinthine layer morphogenesis (GO:0060670)3.50500915
35regulation of podosome assembly (GO:0071801)3.49605328
36cellular response to virus (GO:0098586)3.49470279
37regulation of type 2 immune response (GO:0002828)3.45525560
38response to protozoan (GO:0001562)3.41167622
39positive regulation of defense response to virus by host (GO:0002230)3.41064418
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.39182126
41regulation of RIG-I signaling pathway (GO:0039535)3.37894662
42regulation of interferon-beta biosynthetic process (GO:0045357)3.36338476
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30214200
44germinal center formation (GO:0002467)3.29318791
45positive regulation of NF-kappaB import into nucleus (GO:0042346)3.28913273
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26647356
47* negative regulation of viral process (GO:0048525)3.26383265
48negative regulation of cell killing (GO:0031342)3.26142324
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.26142324
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25023879
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25023879
52positive regulation by organism of defense response of other organism involved in symbiotic interact3.25023879
53modulation by symbiont of host immune response (GO:0052553)3.25023879
54positive regulation by symbiont of host defense response (GO:0052509)3.25023879
55modulation by symbiont of host defense response (GO:0052031)3.25023879
56* regulation of viral genome replication (GO:0045069)3.21442067
57T cell migration (GO:0072678)3.21013160
58* defense response to virus (GO:0051607)3.19819122
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19763989
60regulation of mononuclear cell migration (GO:0071675)3.18174129
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.16123061
62cellular response to interferon-beta (GO:0035458)3.14317314
63regulation of interleukin-12 production (GO:0032655)3.11886848
64negative regulation of type I interferon production (GO:0032480)3.11156825
65granulocyte activation (GO:0036230)3.10555305
66negative regulation of T cell mediated immunity (GO:0002710)3.08707109
67lymphocyte chemotaxis (GO:0048247)3.08435215
68negative regulation of production of molecular mediator of immune response (GO:0002701)3.07644349
69neutrophil activation involved in immune response (GO:0002283)3.07594125
70regulation of immunoglobulin secretion (GO:0051023)3.07370046
71positive regulation of acute inflammatory response (GO:0002675)3.07183352
72regulation of T-helper cell differentiation (GO:0045622)3.06478037
73positive regulation of nitric oxide biosynthetic process (GO:0045429)3.06318071
74T-helper 1 type immune response (GO:0042088)3.04477921
75myeloid dendritic cell activation (GO:0001773)3.04273895
76regulation of membrane protein ectodomain proteolysis (GO:0051043)3.03964510
77positive regulation of toll-like receptor signaling pathway (GO:0034123)3.03908526
78regulation of T-helper 2 cell differentiation (GO:0045628)3.02332641
79negative regulation of myeloid cell apoptotic process (GO:0033033)3.01798981
80detection of other organism (GO:0098543)3.00553540
81* cellular response to interferon-gamma (GO:0071346)3.00083032
82regulation of interleukin-8 biosynthetic process (GO:0045414)2.99785789
83regulation of nitric oxide biosynthetic process (GO:0045428)2.99510849
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.98829724
85negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97756803
86regulation of T cell tolerance induction (GO:0002664)2.97530081
87cellular response to lipopolysaccharide (GO:0071222)2.97027900
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.95630121
89positive regulation of interleukin-6 production (GO:0032755)2.94051002
90antigen processing and presentation of endogenous antigen (GO:0019883)2.93648913
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91574541
92cellular response to molecule of bacterial origin (GO:0071219)2.90922822
93regulation of defense response to virus by host (GO:0050691)2.89399832
94regulation of heat generation (GO:0031650)2.89224634
95* response to interferon-gamma (GO:0034341)2.89009146
96interferon-gamma secretion (GO:0072643)2.88792614
97negative regulation of nitric oxide biosynthetic process (GO:0045019)2.88627549
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87659301
99negative regulation of type 2 immune response (GO:0002829)2.87346499
100regulation of antigen processing and presentation (GO:0002577)2.86184075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.81384601
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.76865565
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.45027864
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.67386533
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.20570050
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.90958785
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61151467
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.52915517
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31595620
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04361629
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.01103718
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.97399703
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91733360
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.87143305
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.83386106
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81295875
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62795407
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39524676
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19397714
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09507541
21GATA1_22025678_ChIP-Seq_K562_Human2.03058227
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01666224
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01569106
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91525045
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75774628
26MYB_26560356_Chip-Seq_TH2_Human1.73330815
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.71698971
28SPI1_23547873_ChIP-Seq_NB4_Human1.68391496
29VDR_24763502_ChIP-Seq_THP-1_Human1.68191292
30* MAF_26560356_Chip-Seq_TH1_Human1.67694529
31VDR_24787735_ChIP-Seq_THP-1_Human1.66766599
32RUNX_20019798_ChIP-Seq_JUKART_Human1.65207280
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61420810
34SPI1_23127762_ChIP-Seq_K562_Human1.57995214
35VDR_21846776_ChIP-Seq_THP-1_Human1.48592632
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47638829
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46384112
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39000872
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37062986
40MYB_26560356_Chip-Seq_TH1_Human1.36764945
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.36481297
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31043109
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30494347
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30256783
45SCL_19346495_ChIP-Seq_HPC-7_Human1.29547754
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24882637
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24627411
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24594839
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23018843
50UTX_26944678_Chip-Seq_JUKART_Human1.20851711
51GATA3_26560356_Chip-Seq_TH2_Human1.20224507
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19432614
53PU_27001747_Chip-Seq_BMDM_Mouse1.18750176
54MAF_26560356_Chip-Seq_TH2_Human1.18416508
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16600584
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.16475056
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.15403369
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.15344765
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14183194
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14149235
61GATA3_27048872_Chip-Seq_THYMUS_Human1.13781459
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12637253
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11527364
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11176204
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10025666
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09861072
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08041819
68EGR1_19032775_ChIP-ChIP_M12_Human1.07566971
69KDM2B_26808549_Chip-Seq_DND41_Human1.00901178
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00144190
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00014397
72TCF7_22412390_ChIP-Seq_EML_Mouse0.99902735
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99732716
74GATA1_19941827_ChIP-Seq_MEL_Mouse0.97354276
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97116630
76GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96878999
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94563338
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94098626
79RXR_22158963_ChIP-Seq_LIVER_Mouse0.93341060
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92988379
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91696111
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90683941
83PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88412554
84LXR_22292898_ChIP-Seq_THP-1_Human0.87893763
85ESR1_21235772_ChIP-Seq_MCF-7_Human0.87457816
86GATA1_19941826_ChIP-Seq_K562_Human0.85689804
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80222199
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77758884
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75570978
90* SOX2_20726797_ChIP-Seq_SW620_Human0.75382966
91LXR_22158963_ChIP-Seq_LIVER_Mouse0.75280125
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75071706
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74904679
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74904679
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74904679
96* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74360422
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73765079
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72098329
99* STAT1_20625510_ChIP-Seq_HELA_Human0.71605694
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69845698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.57673396
2MP0003724_increased_susceptibility_to4.24588921
3MP0006082_CNS_inflammation4.07896487
4MP0009785_altered_susceptibility_to3.84698737
5MP0003436_decreased_susceptibility_to3.65652668
6MP0001835_abnormal_antigen_presentation3.50863319
7MP0002148_abnormal_hypersensitivity_rea3.45446570
8MP0004510_myositis3.05351257
9MP0005671_abnormal_response_to2.95978254
10MP0005000_abnormal_immune_tolerance2.94032505
11MP0005387_immune_system_phenotype2.82676651
12MP0001790_abnormal_immune_system2.82676651
13MP0005025_abnormal_response_to2.76983416
14MP0003300_gastrointestinal_ulcer2.52602861
15MP0002419_abnormal_innate_immunity2.50825528
16MP0001800_abnormal_humoral_immune2.40825735
17MP0002723_abnormal_immune_serum2.38367796
18MP0009764_decreased_sensitivity_to2.34723860
19MP0002452_abnormal_antigen_presenting2.26677521
20MP0004947_skin_inflammation2.26392491
21MP0001533_abnormal_skeleton_physiology2.14342537
22MP0005058_abnormal_lysosome_morphology2.09011632
23MP0002139_abnormal_hepatobiliary_system2.01786129
24MP0005451_abnormal_body_composition2.00459261
25MP0008004_abnormal_stomach_pH1.98750273
26MP0010155_abnormal_intestine_physiology1.98485203
27MP0003075_altered_response_to1.97346095
28MP0001819_abnormal_immune_cell1.93275712
29MP0002420_abnormal_adaptive_immunity1.92564157
30MP0002332_abnormal_exercise_endurance1.85621399
31MP0000685_abnormal_immune_system1.84739413
32MP0001845_abnormal_inflammatory_respons1.84552534
33MP0008469_abnormal_protein_level1.75789487
34MP0001853_heart_inflammation1.74370883
35MP0009333_abnormal_splenocyte_physiolog1.70742064
36MP0009840_abnormal_foam_cell1.68012131
37MP0003195_calcinosis1.63996571
38MP0000343_altered_response_to1.58423117
39MP0002405_respiratory_system_inflammati1.57227552
40MP0003453_abnormal_keratinocyte_physiol1.55801456
41MP0009278_abnormal_bone_marrow1.53205916
42MP0003448_altered_tumor_morphology1.49953467
43MP0003806_abnormal_nucleotide_metabolis1.45405345
44MP0002254_reproductive_system_inflammat1.43971579
45MP0000716_abnormal_immune_system1.41506277
46MP0006054_spinal_hemorrhage1.38224648
47MP0005310_abnormal_salivary_gland1.36390319
48MP0005166_decreased_susceptibility_to1.34227802
49MP0003191_abnormal_cellular_cholesterol1.33578993
50MP0005397_hematopoietic_system_phenotyp1.31753224
51MP0001545_abnormal_hematopoietic_system1.31753224
52MP0003763_abnormal_thymus_physiology1.27974613
53MP0002398_abnormal_bone_marrow1.26159666
54MP0000858_altered_metastatic_potential1.26016522
55MP0005167_abnormal_blood-brain_barrier1.21125428
56MP0003690_abnormal_glial_cell1.20229617
57MP0009763_increased_sensitivity_to1.16950362
58MP0002998_abnormal_bone_remodeling1.15124032
59MP0003172_abnormal_lysosome_physiology1.12338139
60MP0005164_abnormal_response_to1.11090181
61MP0005464_abnormal_platelet_physiology1.10931446
62MP0000604_amyloidosis1.08679288
63MP0003656_abnormal_erythrocyte_physiolo1.07952283
64MP0002429_abnormal_blood_cell1.06613500
65MP0002138_abnormal_hepatobiliary_system1.03789385
66MP0000689_abnormal_spleen_morphology1.01171817
67MP0002722_abnormal_immune_system0.99431334
68MP0009765_abnormal_xenobiotic_induced0.90355553
69MP0001501_abnormal_sleep_pattern0.89715163
70MP0005390_skeleton_phenotype0.88622399
71MP0003091_abnormal_cell_migration0.86560552
72MP0001542_abnormal_bone_strength0.86414681
73MP0005165_increased_susceptibility_to0.84565151
74MP0004883_abnormal_blood_vessel0.77710047
75MP0001663_abnormal_digestive_system0.77312947
76MP0003646_muscle_fatigue0.75909964
77MP0002933_joint_inflammation0.74992937
78MP0005666_abnormal_adipose_tissue0.73993127
79MP0005023_abnormal_wound_healing0.73881519
80MP0008874_decreased_physiological_sensi0.71760198
81MP0002277_abnormal_respiratory_mucosa0.71300994
82MP0001873_stomach_inflammation0.70898903
83MP0003045_fibrosis0.70487789
84MP0005535_abnormal_body_temperature0.68428951
85MP0000920_abnormal_myelination0.68280989
86MP0004808_abnormal_hematopoietic_stem0.66073257
87MP0008260_abnormal_autophagy0.63912810
88MP0005266_abnormal_metabolism0.63362919
89MP0003183_abnormal_peptide_metabolism0.62049752
90MP0002877_abnormal_melanocyte_morpholog0.61927493
91MP0003221_abnormal_cardiomyocyte_apopto0.59198458
92MP0001851_eye_inflammation0.58535945
93MP0000249_abnormal_blood_vessel0.58219378
94MP0000465_gastrointestinal_hemorrhage0.55958484
95MP0000609_abnormal_liver_physiology0.55945981
96MP0005647_abnormal_sex_gland0.55788812
97MP0005319_abnormal_enzyme/_coenzyme0.54680574
98MP0003866_abnormal_defecation0.53619286
99MP0010352_gastrointestinal_tract_polyps0.53106267
100MP0000703_abnormal_thymus_morphology0.52411511

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.30588268
2Optic neuritis (HP:0100653)6.30588268
3Orchitis (HP:0100796)6.15905398
4Myositis (HP:0100614)5.58635920
5Abnormality of glycolipid metabolism (HP:0010969)5.21660220
6Abnormality of liposaccharide metabolism (HP:0010968)5.21660220
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.21660220
8Stomatitis (HP:0010280)4.98506551
9Abnormality of macrophages (HP:0004311)4.88394144
10Recurrent bacterial skin infections (HP:0005406)4.72660716
11Keratoconjunctivitis sicca (HP:0001097)4.46134353
12Eczematoid dermatitis (HP:0000976)4.42504736
13Recurrent abscess formation (HP:0002722)4.26120526
14Keratoconjunctivitis (HP:0001096)4.09988169
15Mediastinal lymphadenopathy (HP:0100721)3.98708868
16Systemic lupus erythematosus (HP:0002725)3.93486287
17Elevated erythrocyte sedimentation rate (HP:0003565)3.88602736
18Increased IgM level (HP:0003496)3.80042480
19Loss of speech (HP:0002371)3.73587768
20Autoimmune thrombocytopenia (HP:0001973)3.67200465
21Vacuolated lymphocytes (HP:0001922)3.58572956
22Gangrene (HP:0100758)3.52212365
23Vasculitis (HP:0002633)3.51043365
24Pulmonary infiltrates (HP:0002113)3.50495935
25Autoimmune hemolytic anemia (HP:0001890)3.37577726
26T lymphocytopenia (HP:0005403)3.29660880
27Disinhibition (HP:0000734)3.28038458
28Parakeratosis (HP:0001036)3.25303019
29Dysostosis multiplex (HP:0000943)3.24721119
30Abnormality of T cell number (HP:0011839)3.22170016
31Recurrent gram-negative bacterial infections (HP:0005420)3.17833443
32Recurrent viral infections (HP:0004429)3.14935639
33Increased cerebral lipofuscin (HP:0011813)3.11139672
34Encephalitis (HP:0002383)3.04345999
35Hypergammaglobulinemia (HP:0010702)3.00705679
36Hemoptysis (HP:0002105)3.00283210
37Recurrent fungal infections (HP:0002841)2.97845057
38Increased IgE level (HP:0003212)2.92709673
39Arterial thrombosis (HP:0004420)2.92030796
40Interstitial pulmonary disease (HP:0006530)2.86103189
41Recurrent skin infections (HP:0001581)2.84924433
42Increased serum ferritin (HP:0003281)2.76837604
43Meningitis (HP:0001287)2.72564673
44Anorexia (HP:0002039)2.71264907
45Gastrointestinal infarctions (HP:0005244)2.64912264
46Joint swelling (HP:0001386)2.63810162
47Nuclear cataract (HP:0100018)2.63166449
48Abnormality of polysaccharide metabolism (HP:0011012)2.60287160
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60287160
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60287160
51Abnormality of the pleura (HP:0002103)2.59476421
52Chronic obstructive pulmonary disease (HP:0006510)2.57385428
53Obstructive lung disease (HP:0006536)2.57385428
54Abnormality of the pericardium (HP:0001697)2.56198687
55Amyloidosis (HP:0011034)2.52706931
56Mutism (HP:0002300)2.51905019
57Gingivitis (HP:0000230)2.51691494
58Basal ganglia calcification (HP:0002135)2.48610219
59Polyneuropathy (HP:0001271)2.48355587
60Hematochezia (HP:0002573)2.45150640
61Urticaria (HP:0001025)2.40447794
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.40208090
63Leukocytosis (HP:0001974)2.39708924
64Urinary glycosaminoglycan excretion (HP:0003541)2.39461481
65Mucopolysacchariduria (HP:0008155)2.39461481
66Progressive neurologic deterioration (HP:0002344)2.37017959
67Pulmonary embolism (HP:0002204)2.36087490
68Episodic fever (HP:0001954)2.33138078
69Keratitis (HP:0000491)2.32072916
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.31353998
71Acne (HP:0001061)2.27054458
72Purpura (HP:0000979)2.26821230
73Abnormality of iron homeostasis (HP:0011031)2.25058413
74Neurofibrillary tangles (HP:0002185)2.24167262
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23671135
76Glomerulonephritis (HP:0000099)2.19612117
77Glomerulopathy (HP:0100820)2.18234192
78Vertigo (HP:0002321)2.16933927
79Abnormality of B cell number (HP:0010975)2.13729050
80Abnormality of the endocardium (HP:0004306)2.11494468
81Chronic otitis media (HP:0000389)2.11207685
82Hepatosplenomegaly (HP:0001433)2.10394497
83Recurrent bronchitis (HP:0002837)2.09409392
84Chronic mucocutaneous candidiasis (HP:0002728)2.07123286
85Recurrent cutaneous fungal infections (HP:0011370)2.07123286
86Petechiae (HP:0000967)2.06792007
87Nausea (HP:0002018)2.04934060
88Abnormality of T cells (HP:0002843)2.03223619
89Axonal loss (HP:0003447)2.02881035
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02585140
91Arthralgia (HP:0002829)2.02146294
92Eosinophilia (HP:0001880)2.02101760
93Pustule (HP:0200039)1.97651022
94Memory impairment (HP:0002354)1.95821586
95B lymphocytopenia (HP:0010976)1.94442785
96Apathy (HP:0000741)1.93545671
97Nasal polyposis (HP:0100582)1.93256407
98Peritonitis (HP:0002586)1.89346958
99Granulocytopenia (HP:0001913)1.88457392
100Diminished motivation (HP:0000745)1.84932767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.86332441
2GRK73.25982529
3MAP3K143.25179259
4TYK23.17406104
5IKBKE3.16633156
6TBK13.13804746
7RIPK13.04131424
8IRAK43.00739402
9TAOK22.80847929
10TXK2.51273391
11MAP4K12.50859743
12NME22.39458315
13RIPK42.38777210
14BLK2.24080946
15IKBKB2.23749555
16MAP3K32.17879967
17MATK2.15636906
18PRPF4B2.15016819
19JAK32.09902950
20DDR22.08033246
21BMPR22.05617721
22MAP3K112.05432931
23JAK11.98649862
24CSK1.92655439
25TAOK11.90967806
26PIM21.87902856
27MOS1.77514908
28MAP2K31.58949219
29ERN11.57172693
30IRAK11.55830795
31FGR1.45345246
32IRAK21.37434907
33ZAP701.32280932
34CHUK1.28708469
35ADRBK21.26500323
36TGFBR21.20118107
37JAK21.15552825
38STK101.07367698
39CDC42BPA1.04936135
40FGFR41.03290568
41LYN1.02907056
42MAP3K11.02287293
43SYK0.99503086
44MAP3K130.97731807
45LCK0.96156421
46TESK20.90922239
47MAP3K50.89349539
48EPHB10.86740183
49BTK0.82288888
50KIT0.80173700
51HCK0.79755153
52CLK10.79279611
53HIPK20.77966664
54EPHA30.74913144
55SIK30.73027034
56ACVR1B0.71631800
57PIM10.68176928
58MARK30.67941293
59MAP2K60.67526153
60FES0.66471505
61CSF1R0.62702255
62ABL20.62377797
63TYRO30.59791920
64TNK20.58781417
65ARAF0.56789949
66FGFR30.54391616
67BMX0.51372932
68LATS20.51130823
69DYRK30.51125347
70TAOK30.50828205
71PKN10.46747339
72ITK0.46369240
73EIF2AK20.40033909
74MAPK40.36253934
75PDK10.36236952
76DAPK20.34674157
77TESK10.34543850
78CAMKK20.28801054
79MAPK70.28270373
80EGFR0.27824144
81ABL10.27316909
82FYN0.27092133
83CDK60.26987213
84INSR0.25257548
85STK240.24230370
86TEC0.24167306
87MAPK110.23615908
88MAPKAPK20.23269564
89DYRK1B0.22576902
90PDPK10.22335198
91PRKCQ0.22280292
92PRKCD0.21782624
93PDGFRB0.20750776
94PAK40.18921528
95PDGFRA0.16287565
96MAP3K60.15547784
97TRIB30.14946334
98MST40.14629477
99CDK40.14628329
100SIK20.11446520

Predicted pathways (KEGG)

RankGene SetZ-score
1Toll-like receptor signaling pathway_Homo sapiens_hsa046203.29883339
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.21581266
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.88970614
4Allograft rejection_Homo sapiens_hsa053302.82624375
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.80878412
6Graft-versus-host disease_Homo sapiens_hsa053322.62818548
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.62297107
8Osteoclast differentiation_Homo sapiens_hsa043802.61859992
9Leishmaniasis_Homo sapiens_hsa051402.49404378
10Malaria_Homo sapiens_hsa051442.47222399
11TNF signaling pathway_Homo sapiens_hsa046682.40571341
12African trypanosomiasis_Homo sapiens_hsa051432.35268349
13Rheumatoid arthritis_Homo sapiens_hsa053232.35116319
14Asthma_Homo sapiens_hsa053102.29748932
15Autoimmune thyroid disease_Homo sapiens_hsa053202.27058466
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24142702
17Staphylococcus aureus infection_Homo sapiens_hsa051502.23728177
18Influenza A_Homo sapiens_hsa051642.20693197
19Measles_Homo sapiens_hsa051622.18041278
20Legionellosis_Homo sapiens_hsa051342.12783290
21Pertussis_Homo sapiens_hsa051332.05373618
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.95807760
23Tuberculosis_Homo sapiens_hsa051521.89157902
24Type I diabetes mellitus_Homo sapiens_hsa049401.84095631
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.83673437
26Other glycan degradation_Homo sapiens_hsa005111.79690321
27Herpes simplex infection_Homo sapiens_hsa051681.77202472
28Hepatitis C_Homo sapiens_hsa051601.70785125
29Salmonella infection_Homo sapiens_hsa051321.68747680
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66508641
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.57249907
32Toxoplasmosis_Homo sapiens_hsa051451.55042655
33Primary immunodeficiency_Homo sapiens_hsa053401.54685076
34Antigen processing and presentation_Homo sapiens_hsa046121.53785725
35Hematopoietic cell lineage_Homo sapiens_hsa046401.51256448
36Lysosome_Homo sapiens_hsa041421.42454388
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37035609
38Chemokine signaling pathway_Homo sapiens_hsa040621.25064762
39Hepatitis B_Homo sapiens_hsa051611.24670853
40Viral myocarditis_Homo sapiens_hsa054161.18815833
41T cell receptor signaling pathway_Homo sapiens_hsa046601.12664895
42B cell receptor signaling pathway_Homo sapiens_hsa046621.11753199
43Prion diseases_Homo sapiens_hsa050201.11246562
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.08386389
45Shigellosis_Homo sapiens_hsa051311.04518491
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99363378
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97635750
48Apoptosis_Homo sapiens_hsa042100.95308112
49Phagosome_Homo sapiens_hsa041450.91536172
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.85931842
51Acute myeloid leukemia_Homo sapiens_hsa052210.81548218
52Amoebiasis_Homo sapiens_hsa051460.80568699
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78696090
54Epstein-Barr virus infection_Homo sapiens_hsa051690.77986745
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77102578
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75898409
57Prolactin signaling pathway_Homo sapiens_hsa049170.74837470
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74315212
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72940672
60Complement and coagulation cascades_Homo sapiens_hsa046100.65787393
61Bladder cancer_Homo sapiens_hsa052190.65368735
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59119715
63VEGF signaling pathway_Homo sapiens_hsa043700.58172204
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56247229
65Type II diabetes mellitus_Homo sapiens_hsa049300.52514472
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44345219
67Sphingolipid metabolism_Homo sapiens_hsa006000.44201229
68Sulfur metabolism_Homo sapiens_hsa009200.43757456
69HTLV-I infection_Homo sapiens_hsa051660.40572409
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.38437074
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37964543
72Viral carcinogenesis_Homo sapiens_hsa052030.37915439
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30744467
74Collecting duct acid secretion_Homo sapiens_hsa049660.30509931
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.29943455
76Systemic lupus erythematosus_Homo sapiens_hsa053220.29139365
77Insulin resistance_Homo sapiens_hsa049310.26393344
78Tryptophan metabolism_Homo sapiens_hsa003800.26081915
79HIF-1 signaling pathway_Homo sapiens_hsa040660.25450979
80Pancreatic cancer_Homo sapiens_hsa052120.25202627
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.24637367
82Chronic myeloid leukemia_Homo sapiens_hsa052200.24502215
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.24272664
84Endocytosis_Homo sapiens_hsa041440.23354648
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23200750
86FoxO signaling pathway_Homo sapiens_hsa040680.21218552
87Notch signaling pathway_Homo sapiens_hsa043300.20084103
88Dorso-ventral axis formation_Homo sapiens_hsa043200.18076916
89MAPK signaling pathway_Homo sapiens_hsa040100.18007474
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17919382
91PPAR signaling pathway_Homo sapiens_hsa033200.15151068
92Galactose metabolism_Homo sapiens_hsa000520.14823316
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14768918
94Small cell lung cancer_Homo sapiens_hsa052220.10174908
95Platelet activation_Homo sapiens_hsa046110.08222645
96Folate biosynthesis_Homo sapiens_hsa007900.07933016
97Fructose and mannose metabolism_Homo sapiens_hsa000510.07736138
98Caffeine metabolism_Homo sapiens_hsa002320.07427556
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.06454718
100Mineral absorption_Homo sapiens_hsa049780.05798709

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