NXPE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transmembrane transport (GO:1902358)9.72291245
2sulfate transport (GO:0008272)8.11174237
3positive regulation of respiratory burst (GO:0060267)8.08278719
4cilium movement (GO:0003341)7.64630815
5ventricular system development (GO:0021591)6.85992681
6intestinal absorption (GO:0050892)6.49329128
7sperm capacitation (GO:0048240)6.46146255
8oligosaccharide biosynthetic process (GO:0009312)6.37220708
9cellular glucuronidation (GO:0052695)6.36998713
10positive regulation of fatty acid beta-oxidation (GO:0032000)6.35312681
11bundle of His cell to Purkinje myocyte communication (GO:0086069)6.29421384
12positive regulation of synaptic transmission, GABAergic (GO:0032230)6.20351309
13uronic acid metabolic process (GO:0006063)6.02258315
14glucuronate metabolic process (GO:0019585)6.02258315
15axoneme assembly (GO:0035082)5.92403592
16regulation of respiratory burst (GO:0060263)5.86679750
17renal system process involved in regulation of blood volume (GO:0001977)5.72958985
18regulation of guanylate cyclase activity (GO:0031282)5.62760635
19glucocorticoid biosynthetic process (GO:0006704)5.58074933
20flavonoid metabolic process (GO:0009812)5.52661463
21ethanol oxidation (GO:0006069)5.40996758
22left/right axis specification (GO:0070986)5.37713926
23calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.35919908
24axonemal dynein complex assembly (GO:0070286)5.29348573
25one-carbon metabolic process (GO:0006730)5.29150252
26negative regulation of myotube differentiation (GO:0010832)5.26872473
27cilium or flagellum-dependent cell motility (GO:0001539)5.24444428
28regulation of intracellular pH (GO:0051453)5.19860481
29transcytosis (GO:0045056)5.12479749
30epithelial cilium movement (GO:0003351)5.10510381
31positive regulation of fatty acid oxidation (GO:0046321)4.99890883
32bile acid and bile salt transport (GO:0015721)4.93310379
33regulation of vitamin metabolic process (GO:0030656)4.87999485
34regulation of cellular pH (GO:0030641)4.78986017
35desmosome organization (GO:0002934)4.75721327
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.59356779
37purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.59356779
38sulfur amino acid catabolic process (GO:0000098)4.55197723
39receptor guanylyl cyclase signaling pathway (GO:0007168)4.54969311
40maintenance of gastrointestinal epithelium (GO:0030277)4.50164744
41O-glycan processing (GO:0016266)4.43949421
42one-carbon compound transport (GO:0019755)4.41718420
43ethanol metabolic process (GO:0006067)4.25748505
44labyrinthine layer development (GO:0060711)4.24509800
45lymph vessel development (GO:0001945)4.23654536
46sulfur compound transport (GO:0072348)4.16635224
47regulation of pH (GO:0006885)4.16556573
48protein localization to endosome (GO:0036010)4.15776686
49cellular response to pH (GO:0071467)4.13951765
50GTP biosynthetic process (GO:0006183)4.13621142
51positive regulation of pseudopodium assembly (GO:0031274)4.11267812
52regulation of systemic arterial blood pressure by hormone (GO:0001990)4.08828971
53regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.08828971
54endocrine process (GO:0050886)4.08828971
55UDP-N-acetylglucosamine metabolic process (GO:0006047)4.08077023
56renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.06898776
57regulation of fatty acid beta-oxidation (GO:0031998)4.05487871
58cGMP-mediated signaling (GO:0019934)3.99494039
59nucleoside diphosphate phosphorylation (GO:0006165)3.89521407
60regulation of cholesterol homeostasis (GO:2000188)3.85592905
61positive regulation of systemic arterial blood pressure (GO:0003084)3.83195174
62protoporphyrinogen IX metabolic process (GO:0046501)3.78389406
63intestinal epithelial cell development (GO:0060576)3.76422203
64response to methylmercury (GO:0051597)3.76233089
65ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.75047214
66nucleoside bisphosphate biosynthetic process (GO:0033866)3.75047214
67purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.75047214
68cellular monovalent inorganic cation homeostasis (GO:0030004)3.74073479
69pyrimidine-containing compound transmembrane transport (GO:0072531)3.69089790
70response to acidic pH (GO:0010447)3.68778491
71actin filament depolymerization (GO:0030042)3.68489433
72regulation of pseudopodium assembly (GO:0031272)3.68307266
73thrombin receptor signaling pathway (GO:0070493)3.67218448
74UTP metabolic process (GO:0046051)3.66336224
75monovalent inorganic cation homeostasis (GO:0055067)3.63874428
76cellular ketone body metabolic process (GO:0046950)3.61869216
77nucleoside diphosphate biosynthetic process (GO:0009133)3.61550004
78UTP biosynthetic process (GO:0006228)3.61227986
79negative regulation of leukocyte chemotaxis (GO:0002689)3.59644693
80endothelium development (GO:0003158)3.58343647
81protoporphyrinogen IX biosynthetic process (GO:0006782)3.55848264
82positive regulation of guanylate cyclase activity (GO:0031284)3.51153771
83endothelial cell morphogenesis (GO:0001886)3.50428420
84sodium ion homeostasis (GO:0055078)3.49144427
85excretion (GO:0007588)3.47023253
86nucleotide-sugar biosynthetic process (GO:0009226)3.45656414
87intermediate filament organization (GO:0045109)3.41891556
88regulation of systemic arterial blood pressure (GO:0003073)3.41217580
89ventricular cardiac muscle cell action potential (GO:0086005)3.39355747
90peptidyl-tyrosine autophosphorylation (GO:0038083)3.38040443
91regulation of cGMP biosynthetic process (GO:0030826)3.37889453
92positive regulation of cellular response to insulin stimulus (GO:1900078)3.37311522
93drug transmembrane transport (GO:0006855)3.33260882
94central nervous system myelination (GO:0022010)3.31739247
95axon ensheathment in central nervous system (GO:0032291)3.31739247
96digestive system process (GO:0022600)3.29923991
97nerve growth factor signaling pathway (GO:0038180)3.26685381
98auditory receptor cell differentiation (GO:0042491)3.25544525
99fucosylation (GO:0036065)3.25368241
100positive regulation of response to oxidative stress (GO:1902884)3.24395874
101positive regulation of cellular response to oxidative stress (GO:1900409)3.24395874
102epithelial structure maintenance (GO:0010669)3.24156831
103microtubule bundle formation (GO:0001578)3.21630219
104receptor recycling (GO:0001881)3.21223962
105regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.20412423
106regulation of pigment cell differentiation (GO:0050932)3.19517591
107regulation of viral release from host cell (GO:1902186)3.18904920
108response to food (GO:0032094)3.17493551
109ketone body metabolic process (GO:1902224)3.16642315
110cellular response to cAMP (GO:0071320)3.16540637
111blood vessel maturation (GO:0001955)3.15286221
112lipid translocation (GO:0034204)3.12245098
113phospholipid translocation (GO:0045332)3.12245098
114negative regulation of keratinocyte proliferation (GO:0010839)3.11040190
115epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08227591
116gap junction assembly (GO:0016264)3.05900422
117membrane hyperpolarization (GO:0060081)3.05113452
118lymphangiogenesis (GO:0001946)3.04758955
119multicellular organismal aging (GO:0010259)3.04700151
120glomerular filtration (GO:0003094)3.04481459
121negative regulation of inclusion body assembly (GO:0090084)3.03775798
122glucocorticoid metabolic process (GO:0008211)3.03074986
123cytoskeletal anchoring at plasma membrane (GO:0007016)3.02733952
124phenylpropanoid metabolic process (GO:0009698)2.97106522
125motile cilium assembly (GO:0044458)2.96851572
126positive regulation of lipid catabolic process (GO:0050996)2.96216551
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.96111666
128chloride transmembrane transport (GO:1902476)2.95419124
129inorganic anion transmembrane transport (GO:0098661)2.94916646
130gas transport (GO:0015669)2.94830373
131protein localization to cell surface (GO:0034394)2.94237975
132activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.91391400
133fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.89849212
134retina vasculature morphogenesis in camera-type eye (GO:0061299)2.81743562
135vascular endothelial growth factor signaling pathway (GO:0038084)2.80318847
136regulation of macrophage chemotaxis (GO:0010758)2.72745515
137renal filtration (GO:0097205)2.68517264
138membrane assembly (GO:0071709)2.67501655
139positive regulation of vasculogenesis (GO:2001214)2.61493231
140positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.60999089
141L-amino acid import (GO:0043092)2.59908719
142cilium organization (GO:0044782)2.58833596
143establishment of nucleus localization (GO:0040023)2.56361440
144positive regulation of Rap GTPase activity (GO:0032854)2.54565646
145regulation of glucose import in response to insulin stimulus (GO:2001273)2.46966685
146negative regulation of neurotransmitter secretion (GO:0046929)2.46469131
147cilium morphogenesis (GO:0060271)2.46439989
148SMAD protein complex assembly (GO:0007183)2.46273228
149substrate-independent telencephalic tangential migration (GO:0021826)2.45474295
150substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.45474295
151regulation of endothelial cell differentiation (GO:0045601)2.44611276
152regulation of Rap GTPase activity (GO:0032317)2.44278098
153locomotory exploration behavior (GO:0035641)2.43704307
154erythrocyte maturation (GO:0043249)2.42861219
155import into cell (GO:0098657)2.41593491
156synaptic vesicle maturation (GO:0016188)2.40453221
157intraciliary transport (GO:0042073)2.37145247
158microtubule-based movement (GO:0007018)2.36463888
159brain morphogenesis (GO:0048854)2.34907698
160protein targeting to plasma membrane (GO:0072661)2.34280973
161establishment of endothelial barrier (GO:0061028)2.33816259
162regulation of vasculogenesis (GO:2001212)2.33770458
163regulation of cardiac muscle cell contraction (GO:0086004)2.33724001
164negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32893215
165bicarbonate transport (GO:0015701)2.32450687
166asymmetric protein localization (GO:0008105)2.31629569
167ovulation from ovarian follicle (GO:0001542)2.31614365
168glomerular epithelial cell development (GO:0072310)2.30509195
169nucleotide phosphorylation (GO:0046939)2.29010703
170negative regulation of neurotransmitter transport (GO:0051589)2.28889711
171clathrin coat assembly (GO:0048268)2.28258021
172oligodendrocyte differentiation (GO:0048709)2.24566073
173porphyrin-containing compound biosynthetic process (GO:0006779)2.23706847
174axon ensheathment (GO:0008366)2.23689313
175ensheathment of neurons (GO:0007272)2.23689313
176regulation of sarcomere organization (GO:0060297)2.23672612
177photoreceptor cell differentiation (GO:0046530)2.23537750
178eye photoreceptor cell differentiation (GO:0001754)2.23537750
179camera-type eye morphogenesis (GO:0048593)2.22836557
180myelination (GO:0042552)2.22571288
181endothelial cell differentiation (GO:0045446)2.22325532
182response to nerve growth factor (GO:1990089)2.21533850
183cellular response to nerve growth factor stimulus (GO:1990090)2.21533850
184Rap protein signal transduction (GO:0032486)2.21497934
185angiogenesis involved in wound healing (GO:0060055)2.20514882
186cilium assembly (GO:0042384)2.19957412
187regulation of p38MAPK cascade (GO:1900744)2.18848652
188positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.17182059
189cell migration involved in sprouting angiogenesis (GO:0002042)2.16879202
190cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.16174510
191amino acid import (GO:0043090)2.15518596
192vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.14886189
193CTP biosynthetic process (GO:0006241)2.14844823
194CTP metabolic process (GO:0046036)2.14844823
195tetrapyrrole biosynthetic process (GO:0033014)2.13699833
196leukocyte migration involved in inflammatory response (GO:0002523)2.13524164
197positive regulation of macrophage cytokine production (GO:0060907)2.12498708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human6.67785754
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.57675862
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.00380818
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.99544549
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.93813661
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.85742365
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.77898245
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.73058726
9GATA6_25053715_ChIP-Seq_YYC3_Human2.71128214
10GATA4_25053715_ChIP-Seq_YYC3_Human2.61494608
11AR_21572438_ChIP-Seq_LNCaP_Human2.61167876
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60945157
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50506972
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.23947664
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13919922
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09774646
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08662506
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05490972
19TCF4_18268006_ChIP-ChIP_LS174T_Human2.04251958
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04126699
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04107301
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03090280
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.98107389
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96454967
25GATA1_22025678_ChIP-Seq_K562_Human1.96294363
26GATA1_19941826_ChIP-Seq_K562_Human1.96076294
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.93543876
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93422789
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88724689
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80362237
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77745311
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76832680
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74960605
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.73144140
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73045336
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72555434
37KLF5_25053715_ChIP-Seq_YYC3_Human1.72414465
38FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.72130092
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68751108
40GBX2_23144817_ChIP-Seq_PC3_Human1.68106808
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67766678
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.67715045
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67283029
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65942984
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65806548
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.64996355
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.64631927
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.64103333
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62958383
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61615096
51RXR_22108803_ChIP-Seq_LS180_Human1.60328843
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.60096773
53ZNF263_19887448_ChIP-Seq_K562_Human1.59595867
54RACK7_27058665_Chip-Seq_MCF-7_Human1.58505482
55CDX2_22108803_ChIP-Seq_LS180_Human1.56911286
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56867328
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56867328
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56738796
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.55353084
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.54896390
61DROSHA_22980978_ChIP-Seq_HELA_Human1.54067645
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53280091
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53134335
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52454874
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51208596
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49608969
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49060189
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.48491414
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47022294
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45709375
71CLOCK_20551151_ChIP-Seq_293T_Human1.45341880
72TAF15_26573619_Chip-Seq_HEK293_Human1.44603241
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44467790
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42052035
75P300_19829295_ChIP-Seq_ESCs_Human1.41647855
76SMAD4_21799915_ChIP-Seq_A2780_Human1.41608709
77AHR_22903824_ChIP-Seq_MCF-7_Human1.41608531
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41462819
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40570758
80BCAT_22108803_ChIP-Seq_LS180_Human1.40293720
81GATA2_19941826_ChIP-Seq_K562_Human1.40136494
82FOXA1_25552417_ChIP-Seq_VCAP_Human1.39029258
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38935651
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.36387993
85CJUN_26792858_Chip-Seq_BT549_Human1.35567657
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34933032
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34933032
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34203515
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34191115
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32658813
91TP53_16413492_ChIP-PET_HCT116_Human1.32386111
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31797785
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.31442517
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30643341
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29739469
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.29651006
97CEBPB_22108803_ChIP-Seq_LS180_Human1.29150458
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28798722
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.28112869
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26088928
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25504993
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25243822
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24535017
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24292985
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24216033
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23919649
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22688598
108TP53_18474530_ChIP-ChIP_U2OS_Human1.22439194
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21360601
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20589757
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20252976
112ER_23166858_ChIP-Seq_MCF-7_Human1.16686155
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.16342826
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16320856
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14439158
116KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.14358396
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13081371
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11096289
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.09961719
120NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09097188
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08268349
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07709892
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07493661
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07361617
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07247023
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05628121
127AR_25329375_ChIP-Seq_VCAP_Human1.05075321
128LXR_22292898_ChIP-Seq_THP-1_Human1.04353299
129SMAD4_21741376_ChIP-Seq_HESCs_Human1.03989418
130FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02744575
131RING1B_27294783_Chip-Seq_ESCs_Mouse1.01709417
132GATA3_24758297_ChIP-Seq_MCF-7_Human1.01639974
133P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01039301
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.00547171
135STAT3_23295773_ChIP-Seq_U87_Human1.00500422
136FOXA2_19822575_ChIP-Seq_HepG2_Human1.00353101
137AR_21909140_ChIP-Seq_LNCAP_Human1.00308016
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99714252
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99159851
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98867056
141TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98209524
142CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97538104
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96476235
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95726499
145HNF4A_19822575_ChIP-Seq_HepG2_Human0.94775537
146SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94140219
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93905079
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93535337
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93317418
150SOX2_20726797_ChIP-Seq_SW620_Human0.93263363
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92964270
152STAT1_20625510_ChIP-Seq_HELA_Human0.91728972
153GATA1_19941827_ChIP-Seq_MEL_Mouse0.91405512
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90927690
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.90142466
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.89329956
157EZH2_22144423_ChIP-Seq_EOC_Human0.89324995
158PRDM14_20953172_ChIP-Seq_ESCs_Human0.87354653
159STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87242067
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86693130
161SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85951886
162SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84138103
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82343785
164CREB1_26743006_Chip-Seq_LNCaP_Human0.82259845
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.80951212
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.78550960
167TP63_22573176_ChIP-Seq_HFKS_Human0.78189097
168PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77826594
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76238592
170E2F1_20622854_ChIP-Seq_HELA_Human0.75943227
171UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75293073
172OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75014820
173FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74145460
174SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74126933
175RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73830321
176SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73550785
177SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73550785
178NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72105059
179ERG_21242973_ChIP-ChIP_JURKAT_Human0.71864738
180KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.71700396
181KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.71700396
182KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.71700396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.20929651
2MP0004043_abnormal_pH_regulation5.29960468
3MP0004147_increased_porphyrin_level4.39836485
4MP0003866_abnormal_defecation4.22637784
5MP0006054_spinal_hemorrhage3.82295907
6MP0005623_abnormal_meninges_morphology3.73695662
7MP0010352_gastrointestinal_tract_polyps3.71662096
8MP0001879_abnormal_lymphatic_vessel3.39236082
9MP0003656_abnormal_erythrocyte_physiolo3.36231933
10MP0010368_abnormal_lymphatic_system3.23876044
11MP0005167_abnormal_blood-brain_barrier3.21409735
12MP0001664_abnormal_digestion2.93339583
13MP0001765_abnormal_ion_homeostasis2.91906770
14MP0003868_abnormal_feces_composition2.89774469
15MP0008004_abnormal_stomach_pH2.86834445
16MP0000477_abnormal_intestine_morphology2.80049307
17MP0000490_abnormal_crypts_of2.75825633
18MP0004264_abnormal_extraembryonic_tissu2.68222460
19MP0005085_abnormal_gallbladder_physiolo2.63886068
20MP0009379_abnormal_foot_pigmentation2.55641711
21MP0002138_abnormal_hepatobiliary_system2.45151483
22MP0004859_abnormal_synaptic_plasticity2.41990678
23MP0010155_abnormal_intestine_physiology2.40997807
24MP0004272_abnormal_basement_membrane2.40182961
25MP0001873_stomach_inflammation2.28849900
26MP0005365_abnormal_bile_salt2.27348583
27MP0003724_increased_susceptibility_to2.08824487
28MP0003690_abnormal_glial_cell2.07393539
29MP0005636_abnormal_mineral_homeostasis2.01347280
30MP0003950_abnormal_plasma_membrane2.00216888
31MP0003136_yellow_coat_color1.97493907
32MP0002796_impaired_skin_barrier1.90661063
33MP0010234_abnormal_vibrissa_follicle1.87221280
34MP0003303_peritoneal_inflammation1.85005022
35MP0001440_abnormal_grooming_behavior1.82206321
36MP0005670_abnormal_white_adipose1.80986973
37MP0008775_abnormal_heart_ventricle1.78945018
38MP0000566_synostosis1.77728997
39MP0003880_abnormal_central_pattern1.76927417
40MP0004215_abnormal_myocardial_fiber1.71444572
41MP0003045_fibrosis1.69018916
42MP0001851_eye_inflammation1.60844537
43MP0001501_abnormal_sleep_pattern1.58636318
44MP0003283_abnormal_digestive_organ1.58119709
45MP0004270_analgesia1.55307391
46MP0002736_abnormal_nociception_after1.54793282
47MP0000537_abnormal_urethra_morphology1.54730225
48MP0004484_altered_response_of1.53563385
49MP0002098_abnormal_vibrissa_morphology1.50247784
50MP0000462_abnormal_digestive_system1.47789941
51MP0005409_darkened_coat_color1.47428277
52MP0002734_abnormal_mechanical_nocicepti1.44438157
53MP0001663_abnormal_digestive_system1.44176908
54MP0001968_abnormal_touch/_nociception1.43496260
55MP0001958_emphysema1.42739076
56MP0003828_pulmonary_edema1.40761270
57MP0000678_abnormal_parathyroid_gland1.39219007
58MP0003635_abnormal_synaptic_transmissio1.38741811
59MP0005171_absent_coat_pigmentation1.38730988
60MP0000230_abnormal_systemic_arterial1.38186987
61MP0000467_abnormal_esophagus_morphology1.37762900
62MP0000749_muscle_degeneration1.37395238
63MP0009046_muscle_twitch1.37361945
64MP0000920_abnormal_myelination1.35382160
65MP0009745_abnormal_behavioral_response1.33614822
66MP0009780_abnormal_chondrocyte_physiolo1.32920758
67MP0002064_seizures1.29878456
68MP0003300_gastrointestinal_ulcer1.28452521
69MP0004782_abnormal_surfactant_physiolog1.27925419
70MP0003279_aneurysm1.26810034
71MP0003693_abnormal_embryo_hatching1.25848191
72MP0003252_abnormal_bile_duct1.24810543
73MP0004510_myositis1.24195327
74MP0005501_abnormal_skin_physiology1.22670140
75MP0001666_abnormal_nutrient_absorption1.19325831
76MP0002254_reproductive_system_inflammat1.19144769
77MP0002332_abnormal_exercise_endurance1.18742735
78MP0004084_abnormal_cardiac_muscle1.18204871
79MP0005165_increased_susceptibility_to1.17961206
80MP0003633_abnormal_nervous_system1.17509383
81MP0001486_abnormal_startle_reflex1.16897705
82MP0003183_abnormal_peptide_metabolism1.15964554
83MP0005381_digestive/alimentary_phenotyp1.13120773
84MP0004036_abnormal_muscle_relaxation1.12995067
85MP0005595_abnormal_vascular_smooth1.12872295
86MP0003075_altered_response_to1.12581905
87MP0002166_altered_tumor_susceptibility1.12512622
88MP0005164_abnormal_response_to1.12192422
89MP0005451_abnormal_body_composition1.12031738
90MP0003705_abnormal_hypodermis_morpholog1.11642827
91MP0004085_abnormal_heartbeat1.11131010
92MP0002133_abnormal_respiratory_system1.10073244
93MP0005388_respiratory_system_phenotype1.10073244
94MP0005310_abnormal_salivary_gland1.09925101
95MP0004885_abnormal_endolymph1.09280193
96MP0004883_abnormal_blood_vessel1.08501243
97MP0003634_abnormal_glial_cell1.07919288
98MP0004145_abnormal_muscle_electrophysio1.02580006
99MP0003091_abnormal_cell_migration1.02377834
100MP0002006_tumorigenesis1.02342574
101MP0005187_abnormal_penis_morphology1.02128167
102MP0006138_congestive_heart_failure1.02079068
103MP0002735_abnormal_chemical_nociception1.00963519
104MP0001756_abnormal_urination1.00799056
105MP0002136_abnormal_kidney_physiology0.99653687
106MP0002295_abnormal_pulmonary_circulatio0.99653228
107MP0002272_abnormal_nervous_system0.99273292
108MP0000778_abnormal_nervous_system0.96370072
109MP0004858_abnormal_nervous_system0.96079892
110MP0009643_abnormal_urine_homeostasis0.95933959
111MP0001970_abnormal_pain_threshold0.95394991
112MP0000013_abnormal_adipose_tissue0.95213538
113MP0003329_amyloid_beta_deposits0.95196297
114MP0001849_ear_inflammation0.95191270
115MP0000465_gastrointestinal_hemorrhage0.93898367
116MP0005257_abnormal_intraocular_pressure0.93065863
117MP0001188_hyperpigmentation0.92141222
118MP0000751_myopathy0.91157133
119MP0003879_abnormal_hair_cell0.91140112
120MP0003567_abnormal_fetal_cardiomyocyte0.90795452
121MP0002063_abnormal_learning/memory/cond0.89513152
122MP0010678_abnormal_skin_adnexa0.89484340
123MP0000767_abnormal_smooth_muscle0.89294958
124MP0002925_abnormal_cardiovascular_devel0.89060153
125MP0000747_muscle_weakness0.87142033
126MP0002572_abnormal_emotion/affect_behav0.87129855
127MP0003631_nervous_system_phenotype0.85542445
128MP0005666_abnormal_adipose_tissue0.84915344
129MP0002876_abnormal_thyroid_physiology0.84672031
130MP0002132_abnormal_respiratory_system0.82244913
131MP0005319_abnormal_enzyme/_coenzyme0.81589846
132MP0005646_abnormal_pituitary_gland0.81401709
133MP0002009_preneoplasia0.79108897
134MP0002128_abnormal_blood_circulation0.78721991
135MP0009785_altered_susceptibility_to0.78616826
136MP0001485_abnormal_pinna_reflex0.77239316
137MP0008874_decreased_physiological_sensi0.76677878
138MP0001216_abnormal_epidermal_layer0.75821699
139MP0005620_abnormal_muscle_contractility0.75737330
140MP0005166_decreased_susceptibility_to0.75189911
141MP0001727_abnormal_embryo_implantation0.71208820
142MP0000249_abnormal_blood_vessel0.70247246
143MP0000377_abnormal_hair_follicle0.70162099
144MP0003315_abnormal_perineum_morphology0.69673700
145MP0000470_abnormal_stomach_morphology0.69370043
146MP0005386_behavior/neurological_phenoty0.68102865
147MP0004924_abnormal_behavior0.68102865
148MP0008872_abnormal_physiological_respon0.68040642
149MP0001544_abnormal_cardiovascular_syste0.66363931
150MP0005385_cardiovascular_system_phenoty0.66363931
151MP0002972_abnormal_cardiac_muscle0.65886189
152MP0004947_skin_inflammation0.65811242
153MP0003453_abnormal_keratinocyte_physiol0.65800639
154MP0004185_abnormal_adipocyte_glucose0.65431677
155MP0002733_abnormal_thermal_nociception0.65134968
156MP0000343_altered_response_to0.64624856
157MP0002896_abnormal_bone_mineralization0.63251954
158MP0006082_CNS_inflammation0.62742286
159MP0002277_abnormal_respiratory_mucosa0.61555023
160MP0005025_abnormal_response_to0.60843644
161MP0005076_abnormal_cell_differentiation0.60152179
162MP0000609_abnormal_liver_physiology0.59948084
163MP0002118_abnormal_lipid_homeostasis0.57737511
164MP0005058_abnormal_lysosome_morphology0.56009582
165MP0002971_abnormal_brown_adipose0.53150535
166MP0000762_abnormal_tongue_morphology0.51870609
167MP0002932_abnormal_joint_morphology0.49982126
168MP0008875_abnormal_xenobiotic_pharmacok0.49068567
169MP0000613_abnormal_salivary_gland0.48180287
170MP0001845_abnormal_inflammatory_respons0.48097743
171MP0003953_abnormal_hormone_level0.48073496
172MP0003191_abnormal_cellular_cholesterol0.47255731
173MP0002822_catalepsy0.47051146
174MP0009333_abnormal_splenocyte_physiolog0.45848598
175MP0009115_abnormal_fat_cell0.44652994
176MP0000627_abnormal_mammary_gland0.43411714

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)8.53585017
2Abnormal respiratory motile cilium physiology (HP:0012261)8.32612204
3Abnormality of renin-angiotensin system (HP:0000847)8.32379232
4Rhinitis (HP:0012384)7.13826431
5Abnormal ciliary motility (HP:0012262)6.98608777
6Flat acetabular roof (HP:0003180)6.93903169
7Abnormality of chloride homeostasis (HP:0011422)6.70563037
8Hyperaldosteronism (HP:0000859)6.17777510
9Chronic bronchitis (HP:0004469)5.94613617
10Alkalosis (HP:0001948)5.75430585
11Hyponatremia (HP:0002902)5.13610029
12Neonatal short-limb short stature (HP:0008921)5.13364033
13Abnormal respiratory epithelium morphology (HP:0012253)4.74851851
14Abnormal respiratory motile cilium morphology (HP:0005938)4.74851851
15Right ventricular cardiomyopathy (HP:0011663)4.71607407
16Flat capital femoral epiphysis (HP:0003370)4.61582976
17Abnormality of the distal phalanx of the thumb (HP:0009617)4.58998877
18Flattened epiphyses (HP:0003071)4.57246867
19Hypokalemia (HP:0002900)4.37320450
20Dynein arm defect of respiratory motile cilia (HP:0012255)4.27648847
21Absent/shortened dynein arms (HP:0200106)4.27648847
22Abnormality of potassium homeostasis (HP:0011042)4.07358275
23Abdominal distention (HP:0003270)4.01144187
24Abnormality of sodium homeostasis (HP:0010931)3.88290676
25Spinal cord compression (HP:0002176)3.81360248
26Hyperkalemia (HP:0002153)3.77255695
27Visceral angiomatosis (HP:0100761)3.64485270
28Breech presentation (HP:0001623)3.62097425
29Conjugated hyperbilirubinemia (HP:0002908)3.60852788
30Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52848886
31Broad distal phalanx of finger (HP:0009836)3.52768734
32Intrahepatic cholestasis (HP:0001406)3.52284704
33Abnormality of the nasal mucosa (HP:0000433)3.51420467
34Abnormal umbilical cord blood vessels (HP:0011403)3.48337133
35Single umbilical artery (HP:0001195)3.48337133
36Abnormality of the fetal cardiovascular system (HP:0010948)3.48337133
37Pancreatic fibrosis (HP:0100732)3.47527726
38Abnormality of the heme biosynthetic pathway (HP:0010472)3.44827256
39Abnormal tarsal ossification (HP:0008369)3.39087944
40Hemangiomatosis (HP:0007461)3.33486406
41Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.27029739
42Vertebral hypoplasia (HP:0008417)3.27029739
43Bronchiectasis (HP:0002110)3.26097594
44Large earlobe (HP:0009748)3.25719847
45Adrenal overactivity (HP:0002717)3.24817983
46Hemorrhage of the eye (HP:0011885)3.12263487
47Nasal polyposis (HP:0100582)3.11747407
48Symphalangism affecting the phalanges of the hand (HP:0009773)3.09695026
49Vertebral clefting (HP:0008428)3.09166332
50Irregular epiphyses (HP:0010582)3.01722491
51Abnormal vertebral ossification (HP:0100569)3.00442086
52True hermaphroditism (HP:0010459)2.98727569
53Bile duct proliferation (HP:0001408)2.95854658
54Abnormal biliary tract physiology (HP:0012439)2.95854658
55Abnormal cartilage morphology (HP:0002763)2.92371422
56Pili torti (HP:0003777)2.91792394
57Bronchitis (HP:0012387)2.89114778
58Polycythemia (HP:0001901)2.76655489
59Abnormality of the 1st metacarpal (HP:0010009)2.76424522
60Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.71335804
61Abnormal biliary tract morphology (HP:0012440)2.66845709
62Syncope (HP:0001279)2.64716757
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64166088
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.64166088
65Abnormality of carpal bone ossification (HP:0006257)2.62807860
66Chronic sinusitis (HP:0011109)2.61006602
67Diaphragmatic weakness (HP:0009113)2.61001790
68Back pain (HP:0003418)2.58316235
69Tubulointerstitial nephritis (HP:0001970)2.45057034
70Aortic aneurysm (HP:0004942)2.42406392
71Termporal pattern (HP:0011008)2.40538528
72Insidious onset (HP:0003587)2.40538528
73Villous atrophy (HP:0011473)2.39813117
74Abnormality of small intestinal villus morphology (HP:0011472)2.39813117
75Abnormality of binocular vision (HP:0011514)2.38943459
76Diplopia (HP:0000651)2.38943459
77Dehydration (HP:0001944)2.35418309
78Short middle phalanx of finger (HP:0005819)2.35167929
79Aplasia/hypoplasia of the femur (HP:0005613)2.33642846
80Abnormal hair laboratory examination (HP:0003328)2.31264049
81Abnormal foot bone ossification (HP:0010675)2.31085812
82Hoarse voice (HP:0001609)2.30105778
83Abnormality of dentin (HP:0010299)2.23904553
84Recurrent sinusitis (HP:0011108)2.21889367
85Hip contracture (HP:0003273)2.18333014
86Congenital sensorineural hearing impairment (HP:0008527)2.16606692
87Abnormality of the umbilical cord (HP:0010881)2.14873490
88Short phalanx of the thumb (HP:0009660)2.14608320
89Poikilocytosis (HP:0004447)2.12599450
90Aplasia involving bones of the extremities (HP:0009825)2.10884480
91Aplasia involving bones of the upper limbs (HP:0009823)2.10884480
92Aplasia of the phalanges of the hand (HP:0009802)2.10884480
93Palpitations (HP:0001962)2.10429966
94Abnormal hand bone ossification (HP:0010660)2.09763429
95Reticulocytosis (HP:0001923)2.08276011
96Cystic liver disease (HP:0006706)2.08047420
97Abnormal ossification of hand bones (HP:0005921)2.07355997
98Vascular tortuosity (HP:0004948)2.05286636
99Hyperparathyroidism (HP:0000843)2.03426912
100Renal tubular acidosis (HP:0001947)2.03292887
101Megalencephaly (HP:0001355)2.02247604
102Increased variability in muscle fiber diameter (HP:0003557)2.01494564
103Occipital encephalocele (HP:0002085)2.01266629
104Hyperactive renin-angiotensin system (HP:0000841)11.9832096
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7587526
106Increased density of long bones (HP:0006392)1.98862317
107Neoplasm of head and neck (HP:0012288)1.98554971
108Esophageal neoplasm (HP:0100751)1.98554971
109Ileus (HP:0002595)1.97430270
110Metabolic alkalosis (HP:0200114)1.95683277
111Recurrent otitis media (HP:0000403)1.94200830
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.94032554
113Postaxial foot polydactyly (HP:0001830)1.93286464
114Pancreatic cysts (HP:0001737)1.92716484
115Lower limb muscle weakness (HP:0007340)1.91679272
116Tubular atrophy (HP:0000092)1.86873247
117Severe short stature (HP:0003510)1.86267958
118Stillbirth (HP:0003826)1.85840247
119Curly hair (HP:0002212)1.85089838
120Abnormality of the corticospinal tract (HP:0002492)1.84212433
121Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.82530767
122Biliary tract neoplasm (HP:0100574)1.82428591
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81782909
124Dicarboxylic aciduria (HP:0003215)1.81782909
125Medial flaring of the eyebrow (HP:0010747)1.80999483
126Congenital hepatic fibrosis (HP:0002612)1.80641144
127Papilledema (HP:0001085)1.80457207
128Cerebral hemorrhage (HP:0001342)1.80145681
129Abnormality of the phalanges of the hallux (HP:0010057)1.80085497
130Asplenia (HP:0001746)1.79429411
131Abnormality of the acetabulum (HP:0003170)1.79252253
132Difficulty running (HP:0009046)1.78738067
133Focal motor seizures (HP:0011153)1.78567578
134Fibular hypoplasia (HP:0003038)1.78387742
135Anencephaly (HP:0002323)1.78334780
136Hyporeflexia of lower limbs (HP:0002600)1.78322588
137Late onset (HP:0003584)1.78146987
138Renal salt wasting (HP:0000127)1.77405287
139Bundle branch block (HP:0011710)1.76541560
140Urinary urgency (HP:0000012)1.75168708
141Gait imbalance (HP:0002141)1.74100437
142Genital tract atresia (HP:0001827)1.72304422
143Rectal prolapse (HP:0002035)1.71290887
144Nephronophthisis (HP:0000090)1.69729429
145Hypotension (HP:0002615)1.69088333
146Congenital primary aphakia (HP:0007707)1.67862628
147Abnormality of the vitamin B12 metabolism (HP:0004341)1.67521453
148Lower limb amyotrophy (HP:0007210)1.67290418
149Aplasia/Hypoplasia of the spleen (HP:0010451)1.67014568
150Hemiplegia (HP:0002301)1.66374092
151Fat malabsorption (HP:0002630)1.66222773
152Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.65339886
153Intention tremor (HP:0002080)1.64014423
154Neurofibrillary tangles (HP:0002185)1.63566106
155Cupped ribs (HP:0000887)1.62888878
156Thin bony cortex (HP:0002753)1.62840304
157Cone-rod dystrophy (HP:0000548)1.61835758
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60685091
159Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.60250437
160Short 1st metacarpal (HP:0010034)1.60250437
161Exercise-induced myalgia (HP:0003738)1.60054605
162Malnutrition (HP:0004395)1.59484981
163Chronic diarrhea (HP:0002028)1.59036500
164Hematochezia (HP:0002573)1.58653262
165Bronchomalacia (HP:0002780)1.58395018
166Petechiae (HP:0000967)1.57560796
167Abnormality of skeletal muscle fiber size (HP:0012084)1.56898694
168Rimmed vacuoles (HP:0003805)1.56001158
169Hip dysplasia (HP:0001385)1.55930424
170Hyperammonemia (HP:0001987)1.55845609
171Stage 5 chronic kidney disease (HP:0003774)1.55742343
172Arterial tortuosity (HP:0005116)1.55667637
173Polydipsia (HP:0001959)1.55495072
174Abnormal drinking behavior (HP:0030082)1.55495072
175Molar tooth sign on MRI (HP:0002419)1.55072174
176Abnormality of midbrain morphology (HP:0002418)1.55072174
177Mildly elevated creatine phosphokinase (HP:0008180)1.54921644
178Ventricular fibrillation (HP:0001663)1.54296143
179Symptomatic seizures (HP:0011145)1.52960101
180Abnormality of vitamin B metabolism (HP:0004340)1.52912040
181Short nail (HP:0001799)1.52835167
182Supernumerary spleens (HP:0009799)1.52486321
183Deviation of the thumb (HP:0009603)1.52374570
184Protuberant abdomen (HP:0001538)1.52124747
185Neoplasm of the rectum (HP:0100743)1.52049598
186Eczematoid dermatitis (HP:0000976)1.52045270
187Full cheeks (HP:0000293)1.51386281
188Hemiparesis (HP:0001269)1.51381327
189Urinary bladder sphincter dysfunction (HP:0002839)1.51158476
190Amelogenesis imperfecta (HP:0000705)1.50702025
191Scanning speech (HP:0002168)1.50502734
192Short hallux (HP:0010109)1.48525731
193Bowel incontinence (HP:0002607)1.47807550
194Broad metatarsal (HP:0001783)1.46799174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA7.00079810
2EPHA26.11087308
3MAPK156.10811946
4MST1R5.92102169
5ACVR1B5.14864434
6TIE14.30879726
7PNCK3.40524876
8DMPK3.17186100
9PTK2B2.52978966
10KDR2.49268038
11STK102.16212748
12GRK12.08947540
13MAP3K101.98278223
14TGFBR21.97093900
15STK391.95233030
16LMTK21.78259217
17WNK41.76585616
18STK241.72325821
19FER1.59962343
20OXSR11.59282951
21ERN11.55948198
22EPHB11.44091008
23SCYL21.41498601
24TESK21.34221382
25MAP2K21.33479163
26CASK1.33244250
27MAPKAPK51.32220995
28DAPK21.29314639
29PHKG11.28817351
30PHKG21.28817351
31GRK51.19835032
32LRRK21.18677374
33PTK21.17056002
34NTRK31.14946476
35TESK11.11226563
36EPHA41.10500865
37KSR21.10255258
38ROCK21.05031985
39NTRK11.04103310
40MYLK1.03931510
41MAP3K121.03467841
42FES1.03060324
43TTN1.01793984
44CAMKK21.00428654
45CDK81.00212858
46MAP2K10.97353124
47SIK10.96710964
48MAP3K20.95100448
49TRIB30.93853529
50ABL20.93044703
51PRKD10.92726582
52PAK30.91540946
53RIPK40.90554026
54MET0.90537276
55VRK10.89332128
56DDR20.88937177
57PAK20.87913440
58MST40.87147832
59PTK60.83255940
60GSK3A0.82463303
61NLK0.82107944
62PDK20.81730532
63SGK2230.80394664
64SGK4940.80394664
65BCR0.80041319
66CDK50.79075371
67PRPF4B0.79032011
68ERBB20.78951771
69PKN10.76084989
70FGR0.75915162
71MAP2K60.75839847
72CSK0.75622629
73MAPK120.74288775
74PRKAA20.72701912
75TAOK10.72296008
76CAMKK10.71398889
77PRKCQ0.69928204
78PRKCE0.69022212
79RIPK10.68966252
80MOS0.68143546
81CDC42BPA0.66864249
82RET0.66280793
83MAPK110.64935100
84PRKCH0.64487081
85PDPK10.63483464
86CAMK2A0.63391525
87MAPKAPK30.63308820
88ITK0.62979389
89ROCK10.62683589
90PAK40.59191879
91SRC0.57546381
92MAP3K40.57303904
93NTRK20.57238974
94RPS6KA20.56807105
95CDK30.55954720
96MAPK70.55168580
97MATK0.54397632
98FGFR40.54339874
99SGK30.53969024
100WNK10.51910444
101TGFBR10.50654747
102CDK90.49594519
103GRK70.49555167
104FGFR20.49375945
105CAMK2B0.49345848
106MAP3K10.48869263
107SGK20.48681130
108CDK190.48597953
109MAP3K90.48561177
110MAPKAPK20.47775363
111PAK60.47527733
112TNIK0.47150395
113SGK10.46564204
114PRKCI0.45758727
115CLK10.45640204
116PDK10.45023448
117EPHA30.44753687
118STK110.44523791
119EPHB20.44131809
120PRKG20.43559197
121SMG10.43536284
122MAP3K130.42128312
123FYN0.41550758
124CSNK1A1L0.40680681
125INSR0.40624576
126TEC0.40322898
127PRKG10.40031903
128BMX0.39821030
129MAPK130.39798470
130CDK140.39661174
131CAMK2D0.38508948
132FGFR30.33557534
133CSNK1A10.33233482
134PRKACG0.31403522
135YES10.28825097
136PRKCA0.27824487
137GRK60.23286085
138NME10.21502971
139PRKAA10.17824805
140TYK20.17602425
141PKN20.13905290
142LYN0.13417379
143DYRK1B0.12977727
144ZAP700.12832701
145KSR10.11899410
146PDGFRA0.11788539
147PRKCB0.10817833
148PRKCD0.09974815
149JAK20.09716787
150RPS6KL10.09202993
151RPS6KC10.09202993
152RPS6KB10.07760286
153IGF1R0.07156759
154BMPR20.06738986
155MAP3K140.06124520
156STK30.04598199
157NEK60.04486159
158NME20.04363079

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.09323431
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.14774075
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.72440119
4Nitrogen metabolism_Homo sapiens_hsa009102.50324729
5Caffeine metabolism_Homo sapiens_hsa002322.30241312
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26217168
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00221644
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91252204
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83179171
10Fatty acid degradation_Homo sapiens_hsa000711.81400891
11Dorso-ventral axis formation_Homo sapiens_hsa043201.80326580
12Gastric acid secretion_Homo sapiens_hsa049711.73702963
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.67407483
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67008065
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.61532563
16Retinol metabolism_Homo sapiens_hsa008301.56758596
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53523074
18Renin secretion_Homo sapiens_hsa049241.51015021
19GABAergic synapse_Homo sapiens_hsa047271.50740551
20Circadian entrainment_Homo sapiens_hsa047131.50361312
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49633595
22Renal cell carcinoma_Homo sapiens_hsa052111.47757843
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44196130
24Fat digestion and absorption_Homo sapiens_hsa049751.43050090
25Salivary secretion_Homo sapiens_hsa049701.42039927
26Histidine metabolism_Homo sapiens_hsa003401.42002983
27Morphine addiction_Homo sapiens_hsa050321.41422916
28Sulfur relay system_Homo sapiens_hsa041221.38009182
29Glutamatergic synapse_Homo sapiens_hsa047241.35022835
30PPAR signaling pathway_Homo sapiens_hsa033201.33380620
31Estrogen signaling pathway_Homo sapiens_hsa049151.31736374
32Amphetamine addiction_Homo sapiens_hsa050311.30882411
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30699372
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29623949
35Axon guidance_Homo sapiens_hsa043601.29499154
36Long-term potentiation_Homo sapiens_hsa047201.28529078
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26964253
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25672949
39Starch and sucrose metabolism_Homo sapiens_hsa005001.24873479
40Focal adhesion_Homo sapiens_hsa045101.23136627
41Gap junction_Homo sapiens_hsa045401.22961306
42Oxytocin signaling pathway_Homo sapiens_hsa049211.22894822
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.22883624
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19035056
45Other glycan degradation_Homo sapiens_hsa005111.18956048
46Arginine biosynthesis_Homo sapiens_hsa002201.16552233
47Dilated cardiomyopathy_Homo sapiens_hsa054141.16192394
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15842802
49Chemical carcinogenesis_Homo sapiens_hsa052041.15423538
50Olfactory transduction_Homo sapiens_hsa047401.13193772
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.12533239
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12145915
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11232207
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08542473
55cAMP signaling pathway_Homo sapiens_hsa040241.08387208
56Cholinergic synapse_Homo sapiens_hsa047251.08133548
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07348930
58Long-term depression_Homo sapiens_hsa047301.06580591
59Dopaminergic synapse_Homo sapiens_hsa047281.05973303
60GnRH signaling pathway_Homo sapiens_hsa049121.04034216
61Insulin secretion_Homo sapiens_hsa049111.03777197
62Ovarian steroidogenesis_Homo sapiens_hsa049131.03160339
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03059593
64Alcoholism_Homo sapiens_hsa050341.02175075
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01789486
66Cocaine addiction_Homo sapiens_hsa050301.01523006
67Rap1 signaling pathway_Homo sapiens_hsa040151.00981169
68Nicotine addiction_Homo sapiens_hsa050331.00147744
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99723416
70Pancreatic secretion_Homo sapiens_hsa049720.99532292
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98913266
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98689548
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.98140304
74Adherens junction_Homo sapiens_hsa045200.97777862
75Butanoate metabolism_Homo sapiens_hsa006500.97004683
76Malaria_Homo sapiens_hsa051440.96924172
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.96551645
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95730804
79Melanogenesis_Homo sapiens_hsa049160.95601722
80ECM-receptor interaction_Homo sapiens_hsa045120.94846834
81Platelet activation_Homo sapiens_hsa046110.94784337
82B cell receptor signaling pathway_Homo sapiens_hsa046620.94607886
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.94503962
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93916214
85Tight junction_Homo sapiens_hsa045300.93779454
86Choline metabolism in cancer_Homo sapiens_hsa052310.92488794
87Calcium signaling pathway_Homo sapiens_hsa040200.90878492
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90537309
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89837239
90Circadian rhythm_Homo sapiens_hsa047100.89696356
91Serotonergic synapse_Homo sapiens_hsa047260.89110645
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87338264
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87039909
94Arginine and proline metabolism_Homo sapiens_hsa003300.82980244
95Proteoglycans in cancer_Homo sapiens_hsa052050.82794455
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81558325
97MAPK signaling pathway_Homo sapiens_hsa040100.80931358
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78952157
99Ras signaling pathway_Homo sapiens_hsa040140.78784357
100Glioma_Homo sapiens_hsa052140.77712658
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.77263013
102Thyroid hormone synthesis_Homo sapiens_hsa049180.77210703
103Salmonella infection_Homo sapiens_hsa051320.76627079
104VEGF signaling pathway_Homo sapiens_hsa043700.76127025
105Tryptophan metabolism_Homo sapiens_hsa003800.76033357
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75539025
107Fructose and mannose metabolism_Homo sapiens_hsa000510.75117353
108African trypanosomiasis_Homo sapiens_hsa051430.74332028
109Prostate cancer_Homo sapiens_hsa052150.73689940
110Propanoate metabolism_Homo sapiens_hsa006400.71390004
111Synaptic vesicle cycle_Homo sapiens_hsa047210.70991073
112Hematopoietic cell lineage_Homo sapiens_hsa046400.70013245
113Systemic lupus erythematosus_Homo sapiens_hsa053220.69594219
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69391867
115Endocytosis_Homo sapiens_hsa041440.68727091
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66981667
117Insulin resistance_Homo sapiens_hsa049310.66189114
118Fatty acid metabolism_Homo sapiens_hsa012120.63781369
119Mineral absorption_Homo sapiens_hsa049780.63689655
120Osteoclast differentiation_Homo sapiens_hsa043800.61393075
121Sphingolipid metabolism_Homo sapiens_hsa006000.59676266
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59078324
123Glycerolipid metabolism_Homo sapiens_hsa005610.57995337
124ErbB signaling pathway_Homo sapiens_hsa040120.57473791
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56872350
126Hepatitis C_Homo sapiens_hsa051600.56465670
127Hippo signaling pathway_Homo sapiens_hsa043900.55784503
128Bile secretion_Homo sapiens_hsa049760.55704500
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55609127
130Pyruvate metabolism_Homo sapiens_hsa006200.55461385
131Wnt signaling pathway_Homo sapiens_hsa043100.55347034
132Amoebiasis_Homo sapiens_hsa051460.54592068
133Vibrio cholerae infection_Homo sapiens_hsa051100.54441813
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.54128124
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52758200
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.52355985
137Type II diabetes mellitus_Homo sapiens_hsa049300.52159858
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49076137
139Tyrosine metabolism_Homo sapiens_hsa003500.48947935
140Galactose metabolism_Homo sapiens_hsa000520.46892878
141Renin-angiotensin system_Homo sapiens_hsa046140.37469558
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33080826
143Peroxisome_Homo sapiens_hsa041460.31657409
144Carbon metabolism_Homo sapiens_hsa012000.30213849
145Protein digestion and absorption_Homo sapiens_hsa049740.29719466
146Glutathione metabolism_Homo sapiens_hsa004800.28616594
147Thyroid cancer_Homo sapiens_hsa052160.23615344
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18265649
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.16811287
150Arachidonic acid metabolism_Homo sapiens_hsa005900.11938013
151Metabolic pathways_Homo sapiens_hsa011000.11121395
152Phenylalanine metabolism_Homo sapiens_hsa003600.10027199
153Ether lipid metabolism_Homo sapiens_hsa005650.08042347
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.07477952
155Pertussis_Homo sapiens_hsa051330.05611612
156Inositol phosphate metabolism_Homo sapiens_hsa005620.04973771
157Collecting duct acid secretion_Homo sapiens_hsa049660.04692046
158Taste transduction_Homo sapiens_hsa047420.03156697
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.02836980
160Shigellosis_Homo sapiens_hsa05131-0.0378417
161HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0340213
162Linoleic acid metabolism_Homo sapiens_hsa00591-0.0325187
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0291559
164Allograft rejection_Homo sapiens_hsa05330-0.0197394
165Fatty acid elongation_Homo sapiens_hsa00062-0.0088799

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