NXF2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)8.02884952
2cilium movement (GO:0003341)7.43864951
3epithelial cilium movement (GO:0003351)7.08416768
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.39315095
5microtubule depolymerization (GO:0007019)5.58785893
6male meiosis (GO:0007140)5.55843276
7DNA methylation involved in gamete generation (GO:0043046)5.41703803
8axoneme assembly (GO:0035082)5.29840120
9synapsis (GO:0007129)5.27036775
10homocysteine metabolic process (GO:0050667)5.23619739
11chromosome condensation (GO:0030261)5.18416796
12sperm motility (GO:0030317)5.09082368
13piRNA metabolic process (GO:0034587)5.05313934
14acrosome reaction (GO:0007340)5.00323493
15regulation of cilium movement (GO:0003352)4.87094394
16rRNA methylation (GO:0031167)4.81339612
17cysteine metabolic process (GO:0006534)4.71121779
18spermatid development (GO:0007286)4.68065052
19chromosome organization involved in meiosis (GO:0070192)4.63282380
20DNA packaging (GO:0006323)4.62253615
21centriole assembly (GO:0098534)4.51006584
22microtubule polymerization or depolymerization (GO:0031109)4.45209456
23male meiosis I (GO:0007141)4.42359851
24synaptonemal complex assembly (GO:0007130)4.34082880
25binding of sperm to zona pellucida (GO:0007339)4.31238253
26left/right pattern formation (GO:0060972)4.18071381
27histone H3-K9 demethylation (GO:0033169)4.16473025
28microtubule nucleation (GO:0007020)4.08200767
29folic acid-containing compound biosynthetic process (GO:0009396)4.04227850
30sperm-egg recognition (GO:0035036)4.03683484
31ventricular system development (GO:0021591)4.02800183
32rRNA modification (GO:0000154)4.02076421
33fusion of sperm to egg plasma membrane (GO:0007342)3.96066462
34meiotic nuclear division (GO:0007126)3.94045904
35protein polyglutamylation (GO:0018095)3.89344829
36centriole replication (GO:0007099)3.88854588
37spermatid nucleus differentiation (GO:0007289)3.74699957
38synaptonemal complex organization (GO:0070193)3.69896898
39meiosis I (GO:0007127)3.61473939
40sperm capacitation (GO:0048240)3.60080104
41microtubule bundle formation (GO:0001578)3.58203359
42spermatogenesis (GO:0007283)3.52940474
43male gamete generation (GO:0048232)3.52087097
44L-serine metabolic process (GO:0006563)3.45597152
45intraciliary transport (GO:0042073)3.43177684
46regulation of microtubule-based movement (GO:0060632)3.36544290
47sulfur amino acid catabolic process (GO:0000098)3.29378289
48cell-cell recognition (GO:0009988)3.28403793
49organic cation transport (GO:0015695)3.27694042
50gamete generation (GO:0007276)3.27250622
51ribosome biogenesis (GO:0042254)3.26485811
52meiotic cell cycle process (GO:1903046)3.19365934
53cilium organization (GO:0044782)3.14368046
54diterpenoid biosynthetic process (GO:0016102)3.13929123
55cilium assembly (GO:0042384)3.07802472
56sex differentiation (GO:0007548)3.06845783
57DNA synthesis involved in DNA repair (GO:0000731)3.04808356
58multicellular organism reproduction (GO:0032504)3.03133640
59plasma membrane fusion (GO:0045026)3.02705293
60negative regulation of inclusion body assembly (GO:0090084)3.00311867
61polyamine biosynthetic process (GO:0006596)3.00152423
62serine family amino acid biosynthetic process (GO:0009070)2.99684299
63regulation of histone H3-K9 methylation (GO:0051570)2.97397307
64meiotic chromosome segregation (GO:0045132)2.96853847
65left/right axis specification (GO:0070986)2.96269363
66mitotic chromosome condensation (GO:0007076)2.94262830
67histone exchange (GO:0043486)2.93405891
68negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.91975656
69folic acid-containing compound metabolic process (GO:0006760)2.90837347
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86724721
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86724721
72fertilization (GO:0009566)2.85395071
73placenta development (GO:0001890)2.83436480
74vitamin transmembrane transport (GO:0035461)2.82328370
75single strand break repair (GO:0000012)2.81925938
76protein-DNA complex disassembly (GO:0032986)2.81360508
77nucleosome disassembly (GO:0006337)2.81360508
78nuclear pore complex assembly (GO:0051292)2.79876932
79histone H3-K36 demethylation (GO:0070544)2.77633283
80acrosome assembly (GO:0001675)2.75652895
81single fertilization (GO:0007338)2.72606334
82positive regulation of endothelial cell differentiation (GO:0045603)2.71014427
83gene silencing by RNA (GO:0031047)2.68429874
84DNA methylation (GO:0006306)2.65433312
85DNA alkylation (GO:0006305)2.65433312
86germ cell development (GO:0007281)2.64671457
87ribosomal small subunit assembly (GO:0000028)2.63020258
88tetrahydrofolate metabolic process (GO:0046653)2.62165376
89microtubule-based movement (GO:0007018)2.60827324
90negative regulation of DNA biosynthetic process (GO:2000279)2.60693693
91histone H4-K12 acetylation (GO:0043983)2.60581498
92male sex determination (GO:0030238)2.59430554
93multicellular organismal reproductive process (GO:0048609)2.59366377
94regulation of translational fidelity (GO:0006450)2.57896379
95chaperone-mediated protein complex assembly (GO:0051131)2.57005206
96RNA localization (GO:0006403)2.56572263
97sister chromatid cohesion (GO:0007062)2.53428087
98gonadal mesoderm development (GO:0007506)10.2948487
99axonemal dynein complex assembly (GO:0070286)10.1623240
100cilium or flagellum-dependent cell motility (GO:0001539)10.0586235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.02872835
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.41389026
3E2F7_22180533_ChIP-Seq_HELA_Human4.28139688
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.98954325
5VDR_22108803_ChIP-Seq_LS180_Human3.17188655
6GATA1_22025678_ChIP-Seq_K562_Human2.84086857
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.31218373
8AR_21909140_ChIP-Seq_LNCAP_Human2.29714138
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14880752
10IGF1R_20145208_ChIP-Seq_DFB_Human2.03274527
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02023264
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.00020301
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.91588892
14P68_20966046_ChIP-Seq_HELA_Human1.90242910
15YY1_22570637_ChIP-Seq_MALME-3M_Human1.82286650
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81936600
17PHF8_20622854_ChIP-Seq_HELA_Human1.77655716
18ZNF274_21170338_ChIP-Seq_K562_Hela1.75282618
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74571681
20E2F1_17053090_ChIP-ChIP_MCF-7_Human1.72141286
21FUS_26573619_Chip-Seq_HEK293_Human1.70210226
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.69490437
23GATA1_19941826_ChIP-Seq_K562_Human1.67531868
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.65475248
25SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.61201999
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.56146780
27SMC4_20622854_ChIP-Seq_HELA_Human1.54745917
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53854959
29NCOR1_26117541_ChIP-Seq_K562_Human1.48832172
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46385749
31KDM5A_27292631_Chip-Seq_BREAST_Human1.44581537
32GATA2_19941826_ChIP-Seq_K562_Human1.43713063
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40962631
34ZNF263_19887448_ChIP-Seq_K562_Human1.40790243
35E2F1_20622854_ChIP-Seq_HELA_Human1.39283147
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38543756
37OCT4_20526341_ChIP-Seq_ESCs_Human1.38400835
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36076377
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35639377
40STAT1_20625510_ChIP-Seq_HELA_Human1.34616643
41TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.32517234
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31836350
43XRN2_22483619_ChIP-Seq_HELA_Human1.28854309
44DROSHA_22980978_ChIP-Seq_HELA_Human1.27591853
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27554863
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26010275
47GABP_19822575_ChIP-Seq_HepG2_Human1.24316839
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23344414
49CBP_20019798_ChIP-Seq_JUKART_Human1.22529602
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22529602
51P300_27268052_Chip-Seq_Bcells_Human1.22215803
52CTCF_27219007_Chip-Seq_Bcells_Human1.21676462
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19594462
54ERA_21632823_ChIP-Seq_H3396_Human1.18532648
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18439464
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.17577921
57CTCF_20526341_ChIP-Seq_ESCs_Human1.16051592
58PHF8_20622853_ChIP-Seq_HELA_Human1.14208013
59TTF2_22483619_ChIP-Seq_HELA_Human1.13685621
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12865693
61NCOR_22424771_ChIP-Seq_293T_Human1.12761530
62RAC3_21632823_ChIP-Seq_H3396_Human1.11790562
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10725846
64ERG_20517297_ChIP-Seq_VCAP_Human1.10559774
65TP63_22573176_ChIP-Seq_HFKS_Human1.09937535
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.08319409
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07867063
68CHD1_26751641_Chip-Seq_LNCaP_Human1.06421831
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04564088
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04450905
71MYC_19829295_ChIP-Seq_ESCs_Human1.02963495
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02538101
73OCT1_27270436_Chip-Seq_PROSTATE_Human1.02336956
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02053442
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01417939
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.01093761
77ER_23166858_ChIP-Seq_MCF-7_Human1.00926377
78ETV1_20927104_ChIP-Seq_GIST48_Human1.00786137
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99955747
80TET1_21490601_ChIP-Seq_MESCs_Mouse0.99581111
81AR_21572438_ChIP-Seq_LNCaP_Human0.99409944
82ETS1_20019798_ChIP-Seq_JURKAT_Human0.99024789
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98705646
84RNF2_27304074_Chip-Seq_NSC_Mouse0.97890367
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97629653
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97562049
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97462354
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96412584
89SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95458495
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94979403
91CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94542058
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93883714
93* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93545539
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93037634
95RBPJ_21746931_ChIP-Seq_IB4_Human0.92187959
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91996028
97BCOR_27268052_Chip-Seq_Bcells_Human0.91870319
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90999127
99HOXB7_26014856_ChIP-Seq_BT474_Human0.90985786
100MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90892030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.98460150
2MP0005410_abnormal_fertilization4.07875210
3MP0003698_abnormal_male_reproductive3.09799636
4MP0003786_premature_aging3.03294106
5MP0001929_abnormal_gametogenesis3.00569024
6MP0003693_abnormal_embryo_hatching2.65263591
7MP0002210_abnormal_sex_determination2.64293578
8MP0002132_abnormal_respiratory_system2.62179220
9MP0000678_abnormal_parathyroid_gland2.46655075
10MP0004147_increased_porphyrin_level2.38899381
11MP0005646_abnormal_pituitary_gland2.22986376
12MP0003136_yellow_coat_color2.22368589
13MP0003718_maternal_effect2.17343130
14MP0001145_abnormal_male_reproductive2.13213053
15MP0000566_synostosis2.09327764
16MP0008058_abnormal_DNA_repair2.07964111
17MP0005377_hearing/vestibular/ear_phenot1.96292875
18MP0003878_abnormal_ear_physiology1.96292875
19MP0005670_abnormal_white_adipose1.93087472
20MP0000653_abnormal_sex_gland1.93051238
21MP0008877_abnormal_DNA_methylation1.91498531
22MP0005083_abnormal_biliary_tract1.84252946
23MP0002161_abnormal_fertility/fecundity1.76650294
24MP0004233_abnormal_muscle_weight1.73651246
25MP0002160_abnormal_reproductive_system1.68657893
26MP0002653_abnormal_ependyma_morphology1.60188892
27MP0008789_abnormal_olfactory_epithelium1.55539866
28MP0003111_abnormal_nucleus_morphology1.51472301
29MP0000383_abnormal_hair_follicle1.44003549
30MP0003315_abnormal_perineum_morphology1.42283322
31MP0003890_abnormal_embryonic-extraembry1.38068821
32MP0005394_taste/olfaction_phenotype1.34724421
33MP0005499_abnormal_olfactory_system1.34724421
34MP0003656_abnormal_erythrocyte_physiolo1.33357253
35MP0005647_abnormal_sex_gland1.27147245
36MP0003077_abnormal_cell_cycle1.24157137
37MP0004043_abnormal_pH_regulation1.20591705
38MP0010094_abnormal_chromosome_stability1.18182080
39MP0000534_abnormal_ureter_morphology1.17798704
40MP0000647_abnormal_sebaceous_gland1.17632942
41MP0002249_abnormal_larynx_morphology1.14263230
42MP0009697_abnormal_copulation1.13557777
43MP0002282_abnormal_trachea_morphology1.12995496
44MP0005636_abnormal_mineral_homeostasis1.12857043
45MP0005395_other_phenotype1.12575591
46MP0008775_abnormal_heart_ventricle1.05052135
47MP0004133_heterotaxia1.04580042
48MP0002736_abnormal_nociception_after1.04380497
49MP0001346_abnormal_lacrimal_gland1.03496495
50MP0004957_abnormal_blastocyst_morpholog0.98593577
51MP0000631_abnormal_neuroendocrine_gland0.98264378
52MP0001661_extended_life_span0.96583623
53MP0004019_abnormal_vitamin_homeostasis0.96033554
54MP0005389_reproductive_system_phenotype0.92049780
55MP0002084_abnormal_developmental_patter0.90417703
56MP0010678_abnormal_skin_adnexa0.89238062
57MP0003183_abnormal_peptide_metabolism0.87805587
58MP0000516_abnormal_urinary_system0.85785422
59MP0005367_renal/urinary_system_phenotyp0.85785422
60MP0002229_neurodegeneration0.85441826
61MP0001944_abnormal_pancreas_morphology0.84059784
62MP0003699_abnormal_female_reproductive0.82901479
63MP0005451_abnormal_body_composition0.82725672
64MP0001968_abnormal_touch/_nociception0.81643253
65MP0003123_paternal_imprinting0.78817549
66MP0001730_embryonic_growth_arrest0.78427754
67MP0001984_abnormal_olfaction0.77452138
68MP0005253_abnormal_eye_physiology0.77304143
69MP0005645_abnormal_hypothalamus_physiol0.76877754
70MP0002269_muscular_atrophy0.75543802
71MP0004145_abnormal_muscle_electrophysio0.75321822
72MP0002085_abnormal_embryonic_tissue0.75105624
73MP0003942_abnormal_urinary_system0.74129740
74MP0002735_abnormal_chemical_nociception0.71834249
75MP0005551_abnormal_eye_electrophysiolog0.71680830
76MP0005220_abnormal_exocrine_pancreas0.70673635
77MP0003936_abnormal_reproductive_system0.69496200
78MP0008932_abnormal_embryonic_tissue0.69380241
79MP0005360_urolithiasis0.68965795
80MP0005332_abnormal_amino_acid0.66805273
81MP0003045_fibrosis0.66116336
82MP0005076_abnormal_cell_differentiation0.65994784
83MP0002080_prenatal_lethality0.65829138
84MP0000026_abnormal_inner_ear0.65408521
85MP0009703_decreased_birth_body0.63933537
86MP0001764_abnormal_homeostasis0.63892073
87MP0002938_white_spotting0.62417230
88MP0005310_abnormal_salivary_gland0.59453097
89MP0001502_abnormal_circadian_rhythm0.59053793
90MP0000013_abnormal_adipose_tissue0.58658095
91MP0002095_abnormal_skin_pigmentation0.58654170
92MP0006035_abnormal_mitochondrial_morpho0.58373795
93MP0003937_abnormal_limbs/digits/tail_de0.58372402
94MP0004185_abnormal_adipocyte_glucose0.58354688
95MP0001119_abnormal_female_reproductive0.57335932
96MP0010307_abnormal_tumor_latency0.57107012
97MP0000427_abnormal_hair_cycle0.56998905
98MP0003861_abnormal_nervous_system0.56885627
99MP0003119_abnormal_digestive_system0.56542144
100MP0001697_abnormal_embryo_size0.55624363

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.03207005
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.95221962
3Absent/shortened dynein arms (HP:0200106)7.95221962
4Abnormal respiratory epithelium morphology (HP:0012253)7.71526320
5Abnormal respiratory motile cilium morphology (HP:0005938)7.71526320
6Abnormal respiratory motile cilium physiology (HP:0012261)7.29788522
7Abnormal ciliary motility (HP:0012262)7.26156057
8Rhinitis (HP:0012384)5.69723661
9Tubulointerstitial nephritis (HP:0001970)4.69267933
10Chronic bronchitis (HP:0004469)4.41028460
11Bronchiectasis (HP:0002110)4.07782145
12Nasal polyposis (HP:0100582)4.02609662
13Infertility (HP:0000789)3.81394116
14Chronic hepatic failure (HP:0100626)3.53585897
15Cystic liver disease (HP:0006706)3.48889502
16Male infertility (HP:0003251)3.35696933
17Abnormal gallbladder physiology (HP:0012438)3.05352838
18Cholecystitis (HP:0001082)3.05352838
19Esophageal varix (HP:0002040)2.97840248
20Abnormality of the nasal mucosa (HP:0000433)2.97220302
21Reticulocytosis (HP:0001923)2.71830181
22Hypoplasia of the uterus (HP:0000013)2.70914248
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68828979
24Abnormality of alanine metabolism (HP:0010916)2.68828979
25Hyperalaninemia (HP:0003348)2.68828979
26Impulsivity (HP:0100710)2.66816998
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.56430560
28Pancreatic fibrosis (HP:0100732)2.55218025
29Occipital encephalocele (HP:0002085)2.46842805
30Abnormality of homocysteine metabolism (HP:0010919)2.41992224
31Homocystinuria (HP:0002156)2.41992224
32Nephronophthisis (HP:0000090)2.40551545
33Chronic otitis media (HP:0000389)2.36266419
34Cone-rod dystrophy (HP:0000548)2.35077092
35Birth length less than 3rd percentile (HP:0003561)2.32696337
36Atelectasis (HP:0100750)2.19562849
37Tubulointerstitial abnormality (HP:0001969)2.13228478
38Chronic sinusitis (HP:0011109)2.13222073
39Unilateral renal agenesis (HP:0000122)2.12710329
40Recurrent sinusitis (HP:0011108)2.12282381
41Polycythemia (HP:0001901)2.09939435
42Abnormality of reticulocytes (HP:0004312)2.09667135
43Severe visual impairment (HP:0001141)2.09394559
44Back pain (HP:0003418)2.04309187
45Bell-shaped thorax (HP:0001591)2.00722843
46True hermaphroditism (HP:0010459)1.98589520
47Aplasia/hypoplasia of the uterus (HP:0008684)1.98285883
48Attenuation of retinal blood vessels (HP:0007843)1.95954119
49Constricted visual fields (HP:0001133)1.94958169
50Short nail (HP:0001799)1.93480447
51Pancreatic cysts (HP:0001737)1.91917808
52Male pseudohermaphroditism (HP:0000037)1.90481959
53Anencephaly (HP:0002323)1.90354903
54Abnormality of the renal medulla (HP:0100957)1.88075315
55Abdominal situs inversus (HP:0003363)1.86594719
56Abnormality of abdominal situs (HP:0011620)1.86594719
57Cholelithiasis (HP:0001081)1.86433250
58Osteomalacia (HP:0002749)1.84289659
59Spontaneous hematomas (HP:0007420)1.82715209
60Hypoparathyroidism (HP:0000829)1.78897076
61Recurrent otitis media (HP:0000403)1.75680048
62Portal hypertension (HP:0001409)1.72349691
63Nephrogenic diabetes insipidus (HP:0009806)1.71685577
64Abnormal sex determination (HP:0012244)1.70718372
65Sex reversal (HP:0012245)1.70718372
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70175077
67Congenital sensorineural hearing impairment (HP:0008527)1.69372219
68Bronchitis (HP:0012387)1.66818497
69Abnormality of sulfur amino acid metabolism (HP:0004339)1.66788123
70Bony spicule pigmentary retinopathy (HP:0007737)1.66013859
71Aplasia/Hypoplasia of the sternum (HP:0006714)1.65922788
72Abnormality of the hepatic vasculature (HP:0006707)1.64847759
73Hyperkalemia (HP:0002153)1.64614682
74Ileus (HP:0002595)1.64549647
75Diaphragmatic weakness (HP:0009113)1.63395922
76Congenital primary aphakia (HP:0007707)1.62679218
77Poor coordination (HP:0002370)1.62258121
78Hypoplastic labia majora (HP:0000059)1.58221544
79Gait imbalance (HP:0002141)1.57708426
80Abnormal gallbladder morphology (HP:0012437)1.57393937
81Chromsome breakage (HP:0040012)1.54826030
82Molar tooth sign on MRI (HP:0002419)1.54318897
83Abnormality of midbrain morphology (HP:0002418)1.54318897
84Gonadotropin excess (HP:0000837)1.54128790
85Bowel incontinence (HP:0002607)1.54114698
86Hyperbilirubinemia (HP:0002904)1.54073074
87Myocardial infarction (HP:0001658)1.54065562
88Abnormality of macular pigmentation (HP:0008002)1.53922928
89Visceral angiomatosis (HP:0100761)1.53342234
90Broad distal phalanx of finger (HP:0009836)1.52679028
91Hyperuricemia (HP:0002149)1.52117926
92Increased purine levels (HP:0004368)1.52117926
93Breast hypoplasia (HP:0003187)1.51336121
94Arteriovenous malformation (HP:0100026)1.50378320
95Sclerocornea (HP:0000647)1.48921486
96Medial flaring of the eyebrow (HP:0010747)1.48102638
97Truncal obesity (HP:0001956)1.48099752
98Azoospermia (HP:0000027)1.47148488
99Sloping forehead (HP:0000340)1.46993706
100Abnormality of dental color (HP:0011073)1.45366818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.54068642
2MAPK153.79782733
3PLK43.61827245
4RPS6KB23.42942066
5PRKD33.24471921
6INSRR2.92942127
7WNK42.76123046
8ICK2.73764352
9CDC72.68037913
10EEF2K2.59296995
11TTK2.15963144
12TSSK62.15383806
13NME12.04249111
14MET1.97994625
15BRD41.94264427
16STK391.86073647
17CAMK1G1.81999310
18PINK11.81752234
19PTK2B1.72449654
20FGR1.58093038
21AKT31.52760308
22BMX1.51313823
23OXSR11.47106811
24PLK21.39691177
25CDK121.35232898
26CDK71.33855980
27EIF2AK11.33385991
28MAP3K41.30814876
29KSR21.24973293
30MST41.24117407
31TRIB31.19056596
32NTRK31.18845819
33CDK91.16103911
34WEE11.15816677
35NEK61.06701093
36SGK21.05243786
37MAP3K31.03219512
38SGK2231.02631190
39SGK4941.02631190
40EPHA21.01725674
41AURKA0.95378432
42SIK10.95186658
43JAK30.94033929
44CCNB10.90285819
45NEK20.89586192
46RPS6KB10.88916742
47PKN20.86082872
48BRSK20.84697837
49PLK10.84291173
50CHEK20.83015379
51MAP2K70.82370902
52SGK30.77902193
53BMPR20.77722569
54JAK20.77341378
55ATR0.76195449
56KSR10.73817909
57MTOR0.73815913
58STK380.73360779
59PASK0.72037666
60MAP3K20.71991437
61CHEK10.70362160
62BRSK10.70229270
63MAP2K30.69902268
64MAP3K70.69171255
65MAP4K20.67140664
66MARK30.66997036
67MST1R0.64121048
68PRKCI0.63180001
69RET0.62676924
70ACVR1B0.58221871
71CDK20.55261022
72MAP2K10.54458265
73MAP3K80.54431870
74ATM0.52443339
75RAF10.51013772
76PAK20.50499435
77CDK10.50370377
78SGK10.43575656
79MAPK130.42602570
80BRAF0.42564363
81PRKAA20.42266101
82CDK30.39555144
83STK100.39463352
84RIPK40.37498571
85RPS6KA10.36807330
86CSNK1E0.36104509
87AKT10.35346901
88MAP3K110.34245849
89NTRK20.33255824
90AKT20.31027993
91PBK0.29984201
92STK40.28736794
93PTK60.27858488
94PAK10.27813661
95STK38L0.27755317
96LMTK20.26393102
97PDPK10.24753605
98CAMK1D0.24689872
99GSK3B0.24554466
100PRKAA10.24390654

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.22279433
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.72417179
3* mRNA surveillance pathway_Homo sapiens_hsa030152.68871599
4* RNA transport_Homo sapiens_hsa030132.61370439
5Fatty acid biosynthesis_Homo sapiens_hsa000612.50618898
6Phenylalanine metabolism_Homo sapiens_hsa003602.32319736
7* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16945248
8Basal transcription factors_Homo sapiens_hsa030222.08778641
9Biosynthesis of amino acids_Homo sapiens_hsa012302.04900708
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99426389
11Arginine biosynthesis_Homo sapiens_hsa002201.96596892
12Pyruvate metabolism_Homo sapiens_hsa006201.96045366
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.94048271
14Olfactory transduction_Homo sapiens_hsa047401.92015940
15Nicotine addiction_Homo sapiens_hsa050331.86862104
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78338274
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.64589407
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.63911190
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61952456
20Nucleotide excision repair_Homo sapiens_hsa034201.59809679
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57208085
22Fanconi anemia pathway_Homo sapiens_hsa034601.53818293
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53729829
24Selenocompound metabolism_Homo sapiens_hsa004501.53583091
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47706596
26Taste transduction_Homo sapiens_hsa047421.47403456
27Tyrosine metabolism_Homo sapiens_hsa003501.37011805
28Arginine and proline metabolism_Homo sapiens_hsa003301.32696927
29DNA replication_Homo sapiens_hsa030301.32630902
30Butanoate metabolism_Homo sapiens_hsa006501.32128868
31Carbon metabolism_Homo sapiens_hsa012001.29112204
32Propanoate metabolism_Homo sapiens_hsa006401.27211507
33Collecting duct acid secretion_Homo sapiens_hsa049661.24746879
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23089571
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22346288
36Huntingtons disease_Homo sapiens_hsa050161.21932029
37Spliceosome_Homo sapiens_hsa030401.19225134
38Fatty acid metabolism_Homo sapiens_hsa012121.18512972
39Hedgehog signaling pathway_Homo sapiens_hsa043401.17350457
40Cell cycle_Homo sapiens_hsa041101.17138582
41Sulfur relay system_Homo sapiens_hsa041221.15478542
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12991417
43Homologous recombination_Homo sapiens_hsa034401.07042441
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06932271
45RNA degradation_Homo sapiens_hsa030181.06837623
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.01430351
47Linoleic acid metabolism_Homo sapiens_hsa005910.99579301
48Mismatch repair_Homo sapiens_hsa034300.99279808
49Oocyte meiosis_Homo sapiens_hsa041140.98396232
50ABC transporters_Homo sapiens_hsa020100.98201654
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96424658
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96380376
53Synaptic vesicle cycle_Homo sapiens_hsa047210.95696704
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94138577
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89024397
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87967666
57Vitamin digestion and absorption_Homo sapiens_hsa049770.85266674
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83421222
59beta-Alanine metabolism_Homo sapiens_hsa004100.83026292
60Chemical carcinogenesis_Homo sapiens_hsa052040.83009988
61mTOR signaling pathway_Homo sapiens_hsa041500.82304074
62Histidine metabolism_Homo sapiens_hsa003400.81518637
63Retinol metabolism_Homo sapiens_hsa008300.81486026
64Type II diabetes mellitus_Homo sapiens_hsa049300.76756481
65Base excision repair_Homo sapiens_hsa034100.71796168
66Purine metabolism_Homo sapiens_hsa002300.71625195
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71540844
68GABAergic synapse_Homo sapiens_hsa047270.71271141
69Peroxisome_Homo sapiens_hsa041460.67313401
70Glutathione metabolism_Homo sapiens_hsa004800.66096308
71Choline metabolism in cancer_Homo sapiens_hsa052310.62926636
72Metabolic pathways_Homo sapiens_hsa011000.62389142
73Sulfur metabolism_Homo sapiens_hsa009200.60549551
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.55185626
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51183822
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49316506
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47012417
78Thyroid cancer_Homo sapiens_hsa052160.46225488
79Insulin signaling pathway_Homo sapiens_hsa049100.45742624
80Regulation of autophagy_Homo sapiens_hsa041400.45550526
81AMPK signaling pathway_Homo sapiens_hsa041520.45349471
82Alcoholism_Homo sapiens_hsa050340.44811100
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44669548
84Fatty acid degradation_Homo sapiens_hsa000710.43506914
85Phototransduction_Homo sapiens_hsa047440.40537487
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40153328
87ErbB signaling pathway_Homo sapiens_hsa040120.39324512
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.38268645
89Serotonergic synapse_Homo sapiens_hsa047260.37811929
90Ether lipid metabolism_Homo sapiens_hsa005650.37578916
91Pentose phosphate pathway_Homo sapiens_hsa000300.37506328
92N-Glycan biosynthesis_Homo sapiens_hsa005100.36604759
93Morphine addiction_Homo sapiens_hsa050320.36065113
94Amphetamine addiction_Homo sapiens_hsa050310.35965187
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32025811
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31706218
97Prostate cancer_Homo sapiens_hsa052150.31493705
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31142647
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28992792
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28567468

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