NUTM2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.30168379
2regulation of ARF GTPase activity (GO:0032312)4.03849818
3mannose metabolic process (GO:0006013)3.70172675
4negative regulation of myotube differentiation (GO:0010832)3.56212884
5histone H3-K36 demethylation (GO:0070544)3.51725581
6positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.37592529
7regulation of RNA export from nucleus (GO:0046831)3.32345446
8regulation of nucleobase-containing compound transport (GO:0032239)3.12342962
9histone lysine demethylation (GO:0070076)3.00966938
10glucocorticoid receptor signaling pathway (GO:0042921)2.98606258
11definitive hemopoiesis (GO:0060216)2.98580914
12insulin-like growth factor receptor signaling pathway (GO:0048009)2.98446266
13corticosteroid receptor signaling pathway (GO:0031958)2.97570247
14histone H3-K9 demethylation (GO:0033169)2.96980105
15histone demethylation (GO:0016577)2.96288861
16regulation of ARF protein signal transduction (GO:0032012)2.95377155
17positive regulation of gamma-delta T cell activation (GO:0046645)2.94855066
18regulation of histone H3-K27 methylation (GO:0061085)2.91011703
19cytoplasmic mRNA processing body assembly (GO:0033962)2.90608278
20response to muramyl dipeptide (GO:0032495)2.87470269
21positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.86560520
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80760361
23cytoskeletal anchoring at plasma membrane (GO:0007016)2.79328620
24monoubiquitinated protein deubiquitination (GO:0035520)2.77659329
25peptidyl-threonine phosphorylation (GO:0018107)2.75334736
26histone H3-K4 trimethylation (GO:0080182)2.74800371
27regulation of NFAT protein import into nucleus (GO:0051532)2.74550209
28regulation of gamma-delta T cell activation (GO:0046643)2.70555172
29cell-substrate adherens junction assembly (GO:0007045)2.69674332
30focal adhesion assembly (GO:0048041)2.69674332
31negative regulation of fatty acid transport (GO:2000192)2.69016778
32regulation of necroptotic process (GO:0060544)2.65950925
33interkinetic nuclear migration (GO:0022027)2.65076354
34regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64478603
35histone H3-K4 methylation (GO:0051568)2.62570733
36striated muscle atrophy (GO:0014891)2.61553360
37skeletal muscle adaptation (GO:0043501)2.60812795
38adherens junction assembly (GO:0034333)2.59739417
39peptidyl-threonine modification (GO:0018210)2.59382756
40regulation of gamma-delta T cell differentiation (GO:0045586)2.50887731
41positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.50789579
42histone lysine methylation (GO:0034968)2.48519458
43histone H3-K9 modification (GO:0061647)2.47667010
44cell-substrate junction assembly (GO:0007044)2.46750894
45protein demethylation (GO:0006482)2.45091726
46protein dealkylation (GO:0008214)2.45091726
47embryonic process involved in female pregnancy (GO:0060136)2.45088633
48maintenance of gastrointestinal epithelium (GO:0030277)2.43828029
49detection of molecule of bacterial origin (GO:0032490)2.43548761
50positive regulation of CREB transcription factor activity (GO:0032793)2.41049941
51intracellular estrogen receptor signaling pathway (GO:0030520)2.38040483
52iron ion import (GO:0097286)2.36529615
533-UTR-mediated mRNA stabilization (GO:0070935)2.36395822
54nerve growth factor signaling pathway (GO:0038180)2.32256951
55response to laminar fluid shear stress (GO:0034616)2.31561593
56epithelial structure maintenance (GO:0010669)2.30196037
57response to epidermal growth factor (GO:0070849)2.29912128
58nuclear pore complex assembly (GO:0051292)2.28190490
59embryonic retina morphogenesis in camera-type eye (GO:0060059)2.27009356
60receptor catabolic process (GO:0032801)2.26805871
61positive regulation of granulocyte differentiation (GO:0030854)2.26760532
62positive regulation of Rap GTPase activity (GO:0032854)2.26425342
63cellular response to epidermal growth factor stimulus (GO:0071364)2.24903837
64cellular response to ethanol (GO:0071361)2.24480243
65regulation of fatty acid beta-oxidation (GO:0031998)2.22111959
66regulation of cholesterol homeostasis (GO:2000188)2.21700487
67hypotonic response (GO:0006971)2.21446308
68semaphorin-plexin signaling pathway (GO:0071526)2.21079335
69apoptotic process involved in morphogenesis (GO:0060561)2.19451242
70regulation of response to osmotic stress (GO:0047484)2.16852965
71phospholipid scrambling (GO:0017121)2.16482962
72positive regulation of myotube differentiation (GO:0010831)2.16442582
73muscle atrophy (GO:0014889)2.14581447
74negative regulation of granulocyte differentiation (GO:0030853)2.14117752
75protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.13964330
76germinal center formation (GO:0002467)2.12820052
77TOR signaling (GO:0031929)2.11576215
78megakaryocyte development (GO:0035855)2.10535834
79negative regulation of striated muscle cell differentiation (GO:0051154)2.10275999
80positive regulation of histone deacetylation (GO:0031065)2.09645705
81stress granule assembly (GO:0034063)2.09288539
82regulation of leukocyte degranulation (GO:0043300)2.08856075
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.08327915
84embryonic camera-type eye morphogenesis (GO:0048596)2.06332341
85granulocyte differentiation (GO:0030851)2.06190325
86peptidyl-lysine dimethylation (GO:0018027)2.05799590
87coronary vasculature morphogenesis (GO:0060977)2.05788356
88histone H4 deacetylation (GO:0070933)2.05383073
89positive regulation of protein deacetylation (GO:0090312)2.04954531
90cerebellar Purkinje cell differentiation (GO:0021702)2.04941595
91negative regulation of Ras protein signal transduction (GO:0046580)2.04729189
92osteoblast development (GO:0002076)2.04647358
93B cell receptor signaling pathway (GO:0050853)2.04015045
94phospholipid translocation (GO:0045332)2.03715622
95lipid translocation (GO:0034204)2.03715622
96establishment of protein localization to Golgi (GO:0072600)2.02789309
97dosage compensation (GO:0007549)2.02517132
98cell volume homeostasis (GO:0006884)2.02433058
99cell-cell junction maintenance (GO:0045217)2.00012547
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.99953689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM2B_26808549_Chip-Seq_SUP-B15_Human2.75950936
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69182499
3MYC_22102868_ChIP-Seq_BL_Human2.64309851
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55192174
5TCF7_22412390_ChIP-Seq_EML_Mouse2.49412748
6KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.47902744
7VDR_21846776_ChIP-Seq_THP-1_Human2.44878443
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.37399307
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37050817
10DROSHA_22980978_ChIP-Seq_HELA_Human2.30142205
11KDM2B_26808549_Chip-Seq_DND41_Human2.29159163
12GATA1_22025678_ChIP-Seq_K562_Human2.21655527
13KDM2B_26808549_Chip-Seq_K562_Human2.15099742
14SCL_19346495_ChIP-Seq_HPC-7_Human2.12559870
15GATA1_19941826_ChIP-Seq_K562_Human2.07055586
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05279318
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.03915570
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03086813
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.95495652
20GATA1_19941827_ChIP-Seq_MEL_Mouse1.93501689
21SPI1_23127762_ChIP-Seq_K562_Human1.89736013
22LXR_22292898_ChIP-Seq_THP-1_Human1.83103227
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.82819617
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.81019721
25VDR_24763502_ChIP-Seq_THP-1_Human1.72770976
26SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71330274
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70292217
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65790550
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.64071927
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62188485
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59437217
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58519329
33MAF_26560356_Chip-Seq_TH1_Human1.56750853
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54745892
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53918596
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52753588
37RACK7_27058665_Chip-Seq_MCF-7_Human1.52742873
38GATA2_19941826_ChIP-Seq_K562_Human1.52698526
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51067990
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.49058596
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48476761
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46726772
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45634958
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45402408
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45284387
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43498320
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.42841787
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42793353
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41546172
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.35914162
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35696276
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35561211
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34301963
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33217001
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32460793
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30496892
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29949444
58SMC4_20622854_ChIP-Seq_HELA_Human1.28716556
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25046175
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25016445
61CREB1_26743006_Chip-Seq_LNCaP_Human1.24439420
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22804206
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22565947
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22540848
65UTX_26944678_Chip-Seq_JUKART_Human1.22535131
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.22269047
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20899419
68MAF_26560356_Chip-Seq_TH2_Human1.20766324
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19379843
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19129234
71RUNX_20019798_ChIP-Seq_JUKART_Human1.18882139
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17554769
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.16731626
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.15317685
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.15317685
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09011410
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08744210
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04372475
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04125546
80AHR_22903824_ChIP-Seq_MCF-7_Human1.03669076
81NCOR1_26117541_ChIP-Seq_K562_Human1.03123429
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.01355891
83TP53_23651856_ChIP-Seq_MEFs_Mouse1.01002770
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.00462440
85VDR_24787735_ChIP-Seq_THP-1_Human0.99768781
86AR_21572438_ChIP-Seq_LNCaP_Human0.99540017
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99176032
88GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98936376
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97796137
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97399032
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97200574
92P68_20966046_ChIP-Seq_HELA_Human0.96477662
93PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96019079
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95572638
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94702473
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94647825
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94138267
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93020514
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92911834
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91618174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.89126059
2MP0005076_abnormal_cell_differentiation3.56154917
3MP0005409_darkened_coat_color3.23955510
4MP0005451_abnormal_body_composition2.68974419
5MP0003656_abnormal_erythrocyte_physiolo2.58697480
6MP0003091_abnormal_cell_migration2.36927042
7MP0003172_abnormal_lysosome_physiology2.35828272
8MP0002822_catalepsy2.34905594
9MP0002396_abnormal_hematopoietic_system2.32856935
10MP0003300_gastrointestinal_ulcer2.26216118
11MP0008057_abnormal_DNA_replication2.24627919
12MP0009278_abnormal_bone_marrow2.21266685
13MP0008260_abnormal_autophagy2.05795546
14MP0004510_myositis2.03275622
15MP0003303_peritoneal_inflammation1.98194009
16MP0004808_abnormal_hematopoietic_stem1.96960016
17MP0005083_abnormal_biliary_tract1.90310027
18MP0003045_fibrosis1.88227461
19MP0003763_abnormal_thymus_physiology1.85690921
20MP0005058_abnormal_lysosome_morphology1.85443411
21MP0004130_abnormal_muscle_cell1.78662859
22MP0001545_abnormal_hematopoietic_system1.74060880
23MP0005397_hematopoietic_system_phenotyp1.74060880
24MP0008004_abnormal_stomach_pH1.71782860
25MP0003566_abnormal_cell_adhesion1.64130068
26MP0000751_myopathy1.57987341
27MP0003828_pulmonary_edema1.57087455
28MP0004233_abnormal_muscle_weight1.49351955
29MP0004381_abnormal_hair_follicle1.47395601
30MP0003436_decreased_susceptibility_to1.46563517
31MP0003453_abnormal_keratinocyte_physiol1.46491655
32MP0000747_muscle_weakness1.45005490
33MP0000759_abnormal_skeletal_muscle1.39396151
34MP0000733_abnormal_muscle_development1.39179103
35MP0009840_abnormal_foam_cell1.36594927
36MP0000465_gastrointestinal_hemorrhage1.35214885
37MP0004087_abnormal_muscle_fiber1.34299946
38MP0001849_ear_inflammation1.33317114
39MP0003279_aneurysm1.32067048
40MP0010630_abnormal_cardiac_muscle1.29700665
41MP0009115_abnormal_fat_cell1.28941744
42MP0004036_abnormal_muscle_relaxation1.27800976
43MP0005621_abnormal_cell_physiology1.26492785
44MP0004947_skin_inflammation1.24734892
45MP0003329_amyloid_beta_deposits1.24475628
46MP0008961_abnormal_basal_metabolism1.24352474
47MP0005275_abnormal_skin_tensile1.21094118
48MP0003879_abnormal_hair_cell1.20043778
49MP0002998_abnormal_bone_remodeling1.18351080
50MP0002249_abnormal_larynx_morphology1.14538453
51MP0001915_intracranial_hemorrhage1.11237090
52MP0000749_muscle_degeneration1.10730023
53MP0002009_preneoplasia1.10229258
54MP0008438_abnormal_cutaneous_collagen1.07425359
55MP0006138_congestive_heart_failure1.06532266
56MP0003866_abnormal_defecation1.03652886
57MP0003690_abnormal_glial_cell1.03649208
58MP0005257_abnormal_intraocular_pressure0.97472329
59MP0000703_abnormal_thymus_morphology0.96621076
60MP0005310_abnormal_salivary_gland0.96330841
61MP0010368_abnormal_lymphatic_system0.96009892
62MP0010155_abnormal_intestine_physiology0.94057257
63MP0002970_abnormal_white_adipose0.92891510
64MP0003191_abnormal_cellular_cholesterol0.92667873
65MP0009931_abnormal_skin_appearance0.92369537
66MP0002971_abnormal_brown_adipose0.92265846
67MP0002269_muscular_atrophy0.89671594
68MP0002925_abnormal_cardiovascular_devel0.89623504
69MP0002332_abnormal_exercise_endurance0.88365306
70MP0002398_abnormal_bone_marrow0.87544870
71MP0002089_abnormal_postnatal_growth/wei0.86345963
72MP0002106_abnormal_muscle_physiology0.85964689
73MP0002419_abnormal_innate_immunity0.85065838
74MP0001958_emphysema0.84248243
75MP0004084_abnormal_cardiac_muscle0.83834600
76MP0000767_abnormal_smooth_muscle0.83391769
77MP0001348_abnormal_lacrimal_gland0.82499381
78MP0002168_other_aberrant_phenotype0.82027182
79MP0002896_abnormal_bone_mineralization0.81071157
80MP0000383_abnormal_hair_follicle0.79715422
81MP0005464_abnormal_platelet_physiology0.79146159
82MP0002108_abnormal_muscle_morphology0.79031314
83MP0004185_abnormal_adipocyte_glucose0.78006995
84MP0000685_abnormal_immune_system0.77377703
85MP0004264_abnormal_extraembryonic_tissu0.76307886
86MP0005666_abnormal_adipose_tissue0.75461030
87MP0005375_adipose_tissue_phenotype0.73448848
88MP0002405_respiratory_system_inflammati0.73384636
89MP0005334_abnormal_fat_pad0.72795876
90MP0003632_abnormal_nervous_system0.72182155
91MP0002086_abnormal_extraembryonic_tissu0.71798145
92MP0002722_abnormal_immune_system0.70702804
93MP0003646_muscle_fatigue0.70365406
94MP0005369_muscle_phenotype0.70178132
95MP0002877_abnormal_melanocyte_morpholog0.69724713
96MP0003948_abnormal_gas_homeostasis0.69705567
97MP0002127_abnormal_cardiovascular_syste0.67960450
98MP0000604_amyloidosis0.66194259
99MP0001800_abnormal_humoral_immune0.65624927
100MP0000266_abnormal_heart_morphology0.65569761

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.91610099
2Broad face (HP:0000283)3.27631881
3Obstructive sleep apnea (HP:0002870)3.08678294
4Dysmetric saccades (HP:0000641)2.85475370
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.83217674
6Cerebral aneurysm (HP:0004944)2.73925514
7Thin bony cortex (HP:0002753)2.71754609
8Long eyelashes (HP:0000527)2.56844930
9Hyperacusis (HP:0010780)2.54711103
10Centrally nucleated skeletal muscle fibers (HP:0003687)2.33886486
11Aortic aneurysm (HP:0004942)2.32266601
12Increased connective tissue (HP:0009025)2.30920867
13Abnormality of the columella (HP:0009929)2.29252902
14Colitis (HP:0002583)2.25393320
15Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.21152422
16Hemorrhage of the eye (HP:0011885)2.20298354
17Dislocated radial head (HP:0003083)2.17154892
18Narrow palate (HP:0000189)2.15797339
19Aneurysm (HP:0002617)2.11744580
20Genetic anticipation (HP:0003743)2.02577484
21Mitral valve prolapse (HP:0001634)2.02100840
22Mask-like facies (HP:0000298)2.00651540
23Self-mutilation (HP:0000742)1.99882797
24Heterotopia (HP:0002282)1.99714336
25Onion bulb formation (HP:0003383)1.98423932
26Abnormality of the radial head (HP:0003995)1.96513176
27Hyperkalemia (HP:0002153)1.91470114
28Difficulty running (HP:0009046)1.90722813
29Sparse lateral eyebrow (HP:0005338)1.87148883
30Ankyloglossia (HP:0010296)1.86878998
31Macroorchidism (HP:0000053)1.86378137
32Distal lower limb amyotrophy (HP:0008944)1.86112875
33Abnormality of the distal phalanx of the thumb (HP:0009617)1.85780056
34Slow saccadic eye movements (HP:0000514)1.83448225
35Exercise-induced myalgia (HP:0003738)1.82747383
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82405374
37Abnormality of the thoracic spine (HP:0100711)1.79866645
38Flat acetabular roof (HP:0003180)1.79535795
39Poikilocytosis (HP:0004447)1.77908788
40Reticulocytosis (HP:0001923)1.76975256
41Abnormal cortical bone morphology (HP:0003103)1.76573538
42Acute lymphatic leukemia (HP:0006721)1.73525646
43Prolonged bleeding time (HP:0003010)1.73177117
44Persistence of primary teeth (HP:0006335)1.72227912
45Disproportionate tall stature (HP:0001519)1.71754751
46Urethral obstruction (HP:0000796)1.71699899
47Spondylolisthesis (HP:0003302)1.71525938
48Increased variability in muscle fiber diameter (HP:0003557)1.70918357
49Difficulty climbing stairs (HP:0003551)1.69830129
50Germ cell neoplasia (HP:0100728)1.66962029
51Overgrowth (HP:0001548)1.66805496
52Sandal gap (HP:0001852)1.66391228
53Distal upper limb amyotrophy (HP:0007149)1.66036147
54Upper limb amyotrophy (HP:0009129)1.66036147
55Thoracic kyphosis (HP:0002942)1.65133208
56Muscle fiber splitting (HP:0003555)1.64792277
57Genu recurvatum (HP:0002816)1.63510651
58Relative macrocephaly (HP:0004482)1.63134516
59Decreased motor nerve conduction velocity (HP:0003431)1.63035052
60Ulnar bowing (HP:0003031)1.63014744
61Increased cerebral lipofuscin (HP:0011813)1.62654363
62Tapered finger (HP:0001182)1.62555214
63Autoimmune thrombocytopenia (HP:0001973)1.61560632
64Hyporeflexia of lower limbs (HP:0002600)1.61363962
65Lip pit (HP:0100267)1.61329881
66Dilatation of the ascending aorta (HP:0005111)1.59965761
67Broad palm (HP:0001169)1.59769380
68Prominent nose (HP:0000448)1.59275455
69Bowel incontinence (HP:0002607)1.59147445
70Cellulitis (HP:0100658)1.58843705
71Thick eyebrow (HP:0000574)1.58209018
72Truncal obesity (HP:0001956)1.57071778
73Gingivitis (HP:0000230)1.56437799
74Gastrointestinal inflammation (HP:0004386)1.56117387
75Smooth philtrum (HP:0000319)1.54824409
76Asymmetry of the thorax (HP:0001555)1.54433507
77Lower limb amyotrophy (HP:0007210)1.54174864
78Aortic dissection (HP:0002647)1.54036191
79Postural instability (HP:0002172)1.53871820
80Inflammation of the large intestine (HP:0002037)1.51252708
81Laryngomalacia (HP:0001601)1.51087020
82Increased neuronal autofluorescent lipopigment (HP:0002074)1.50370996
83Eczematoid dermatitis (HP:0000976)1.50173879
84Acute myeloid leukemia (HP:0004808)1.49474836
85EMG: neuropathic changes (HP:0003445)1.49253467
86Neonatal hypoglycemia (HP:0001998)1.48612956
87Segmental peripheral demyelination/remyelination (HP:0003481)1.48467649
88Tented upper lip vermilion (HP:0010804)1.46465229
89Bronchomalacia (HP:0002780)1.45310919
90Syringomyelia (HP:0003396)1.45307423
91Spinal cord lesions (HP:0100561)1.45307423
92Advanced eruption of teeth (HP:0006288)1.44666770
93Tracheomalacia (HP:0002779)1.44448308
94Deeply set eye (HP:0000490)1.44248307
95Atrophic scars (HP:0001075)1.44001000
96Mild short stature (HP:0003502)1.43763462
97Abnormal large intestine physiology (HP:0012700)1.43480506
98Long palpebral fissure (HP:0000637)1.43277543
99Polycythemia (HP:0001901)1.42648944
100Abnormality of skeletal muscle fiber size (HP:0012084)1.42524973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.34770385
2TRIB33.68484857
3PRPF4B2.97395071
4ICK2.88839882
5EEF2K2.36016278
6BRD42.20600299
7CAMK1D1.88548362
8MARK21.85686629
9SIK21.84174011
10AKT31.78925446
11MAP3K71.77216658
12RIPK11.69036856
13SIK11.68977836
14CAMK1G1.67070221
15WNK11.66834237
16MAP2K31.59487745
17BLK1.58696246
18MAP3K131.52253991
19PKN21.49108122
20MTOR1.49082890
21CDC42BPA1.46626376
22ERN11.46610662
23TTN1.46413730
24MAP3K101.45250652
25RIPK41.40387385
26FGFR41.31876682
27PDGFRA1.24714533
28SGK31.21027201
29SGK21.16034093
30SMG11.15311169
31TAOK11.13286314
32FGFR31.10991516
33MAP3K61.07011217
34KSR21.04555375
35RET1.01027971
36TRPM70.99464531
37ZAP700.97496256
38STK380.93867890
39HIPK20.93129351
40MST1R0.91084942
41LATS10.86517978
42SGK2230.85721115
43SGK4940.85721115
44PDGFRB0.83934159
45MAP3K20.83790488
46RPS6KA20.83779850
47MAP3K10.82788167
48DDR20.82306021
49CAMKK10.81963675
50RPS6KC10.81412255
51RPS6KL10.81412255
52BTK0.79544804
53MAP4K10.77653236
54PRKAA20.76516596
55MAPK120.75593306
56MAP3K140.75353876
57MELK0.74710803
58TYRO30.74313928
59MAPK110.73186346
60CAMK40.72060714
61OBSCN0.71426987
62RPS6KA60.69871843
63ACVR1B0.67341690
64TNK20.64706971
65HCK0.63400071
66PDPK10.62147997
67MAP3K30.61830257
68PRKD20.61751734
69EPHB10.60975836
70SGK10.60123222
71TAOK20.58464211
72CSF1R0.57086647
73KIT0.56292653
74PIK3CG0.54989631
75JAK10.54344032
76FRK0.54267058
77PRKAA10.53095333
78ERBB20.51319004
79JAK20.51315153
80PDK10.51033816
81CSK0.49910954
82MARK30.48956559
83MATK0.48806148
84FGR0.48108493
85EPHA30.47681975
86MAPK100.47483007
87FES0.47365506
88PTK60.47293408
89CDK60.47188998
90CDK40.46803977
91CHUK0.46657951
92TAOK30.45731520
93LATS20.43622963
94SYK0.42150376
95BMX0.40612559
96NEK20.40135666
97RPS6KA10.37794671
98NLK0.37791386
99TYK20.37495842
100RPS6KB10.36975547

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052211.98671200
2Chronic myeloid leukemia_Homo sapiens_hsa052201.91327174
3Non-small cell lung cancer_Homo sapiens_hsa052231.72236722
4Other glycan degradation_Homo sapiens_hsa005111.68819120
5mTOR signaling pathway_Homo sapiens_hsa041501.54318706
6B cell receptor signaling pathway_Homo sapiens_hsa046621.54256223
7Endometrial cancer_Homo sapiens_hsa052131.52069531
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47996996
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43264736
10Thyroid hormone signaling pathway_Homo sapiens_hsa049191.39643934
11Pancreatic cancer_Homo sapiens_hsa052121.37124953
12VEGF signaling pathway_Homo sapiens_hsa043701.36799455
13Notch signaling pathway_Homo sapiens_hsa043301.34790444
14ErbB signaling pathway_Homo sapiens_hsa040121.33526100
15Osteoclast differentiation_Homo sapiens_hsa043801.32274383
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31328910
17Dorso-ventral axis formation_Homo sapiens_hsa043201.30600622
18Lysine degradation_Homo sapiens_hsa003101.30291776
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30070834
20Glioma_Homo sapiens_hsa052141.26845518
21Choline metabolism in cancer_Homo sapiens_hsa052311.26841432
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23966545
23Renal cell carcinoma_Homo sapiens_hsa052111.23273288
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.23255622
25Type II diabetes mellitus_Homo sapiens_hsa049301.23106534
26Prolactin signaling pathway_Homo sapiens_hsa049171.22086168
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21422307
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21214817
29GnRH signaling pathway_Homo sapiens_hsa049121.20340888
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19901453
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.18578854
32Inositol phosphate metabolism_Homo sapiens_hsa005621.15339729
33Platelet activation_Homo sapiens_hsa046111.13188869
34Long-term potentiation_Homo sapiens_hsa047201.11553397
35Prostate cancer_Homo sapiens_hsa052151.11147875
36Estrogen signaling pathway_Homo sapiens_hsa049151.10601435
37Insulin signaling pathway_Homo sapiens_hsa049101.07398058
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06137422
39FoxO signaling pathway_Homo sapiens_hsa040681.04246723
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03980634
41Insulin resistance_Homo sapiens_hsa049311.02784582
42MicroRNAs in cancer_Homo sapiens_hsa052061.01919380
43Focal adhesion_Homo sapiens_hsa045100.99100947
44ABC transporters_Homo sapiens_hsa020100.97826318
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.97471502
46T cell receptor signaling pathway_Homo sapiens_hsa046600.97142965
47Colorectal cancer_Homo sapiens_hsa052100.97026503
48TNF signaling pathway_Homo sapiens_hsa046680.95902161
49Small cell lung cancer_Homo sapiens_hsa052220.92869485
50AMPK signaling pathway_Homo sapiens_hsa041520.92854345
51Amoebiasis_Homo sapiens_hsa051460.90802601
52Adherens junction_Homo sapiens_hsa045200.90756388
53Hepatitis B_Homo sapiens_hsa051610.90572294
54Bladder cancer_Homo sapiens_hsa052190.87929082
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87065649
56Toxoplasmosis_Homo sapiens_hsa051450.86635402
57MAPK signaling pathway_Homo sapiens_hsa040100.86520633
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85800037
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.85283380
60Thyroid cancer_Homo sapiens_hsa052160.85072178
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84084903
62Hepatitis C_Homo sapiens_hsa051600.83945991
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.83020312
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82879965
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81565422
66Cholinergic synapse_Homo sapiens_hsa047250.81348758
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80513374
68Dilated cardiomyopathy_Homo sapiens_hsa054140.79830959
69Malaria_Homo sapiens_hsa051440.78273149
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.78239436
71Apoptosis_Homo sapiens_hsa042100.78053416
72Leishmaniasis_Homo sapiens_hsa051400.76466941
73Oxytocin signaling pathway_Homo sapiens_hsa049210.76445080
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.76218951
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.75941721
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74874336
77Influenza A_Homo sapiens_hsa051640.73832650
78Proteoglycans in cancer_Homo sapiens_hsa052050.73446806
79Tuberculosis_Homo sapiens_hsa051520.73398406
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.73393117
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.72489783
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69307950
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69269900
84ECM-receptor interaction_Homo sapiens_hsa045120.68077609
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66312912
86Chemokine signaling pathway_Homo sapiens_hsa040620.64037097
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63668615
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63480988
89Measles_Homo sapiens_hsa051620.63041603
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61966926
91Rap1 signaling pathway_Homo sapiens_hsa040150.60945183
92HIF-1 signaling pathway_Homo sapiens_hsa040660.60922857
93Gap junction_Homo sapiens_hsa045400.60702025
94Long-term depression_Homo sapiens_hsa047300.60422979
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59387172
96Viral carcinogenesis_Homo sapiens_hsa052030.57890934
97Endocytosis_Homo sapiens_hsa041440.55893955
98Gastric acid secretion_Homo sapiens_hsa049710.53098182
99cAMP signaling pathway_Homo sapiens_hsa040240.51818932
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.51724149

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