NUTM2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.13106947
2mannose metabolic process (GO:0006013)4.79213703
3regulation of ARF GTPase activity (GO:0032312)4.12913755
4histone H3-K36 demethylation (GO:0070544)4.12242217
5positive regulation of CREB transcription factor activity (GO:0032793)3.88159857
6positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.81988928
7positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.78707515
8response to muramyl dipeptide (GO:0032495)3.64908964
9positive regulation of gamma-delta T cell activation (GO:0046645)3.42199677
10negative regulation of myotube differentiation (GO:0010832)3.30842235
11maintenance of gastrointestinal epithelium (GO:0030277)3.20363242
12positive regulation of histone deacetylation (GO:0031065)3.17954458
13focal adhesion assembly (GO:0048041)3.12055222
14cell-substrate adherens junction assembly (GO:0007045)3.12055222
15histone H3-K4 trimethylation (GO:0080182)3.11133824
16histone H3-K4 methylation (GO:0051568)3.08492162
17cell-substrate junction assembly (GO:0007044)3.08442787
18regulation of gamma-delta T cell activation (GO:0046643)3.05996155
19apoptotic process involved in morphogenesis (GO:0060561)3.03323181
20adherens junction assembly (GO:0034333)3.03192244
21negative regulation of granulocyte differentiation (GO:0030853)3.01232297
22regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.96622338
23cellular response to virus (GO:0098586)2.96464770
24negative regulation of fatty acid transport (GO:2000192)2.95298539
25regulation of NFAT protein import into nucleus (GO:0051532)2.94414429
26histone lysine demethylation (GO:0070076)2.92868006
27positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.91859437
28regulation of gamma-delta T cell differentiation (GO:0045586)2.85423108
29cellular response to epidermal growth factor stimulus (GO:0071364)2.83531019
30regulation of G0 to G1 transition (GO:0070316)2.80095001
31epithelial structure maintenance (GO:0010669)2.79234948
323-UTR-mediated mRNA stabilization (GO:0070935)2.79132665
33histone demethylation (GO:0016577)2.78996476
34insulin-like growth factor receptor signaling pathway (GO:0048009)2.76825632
35positive regulation of protein deacetylation (GO:0090312)2.74501017
36thymic T cell selection (GO:0045061)2.72700088
37regulation of necroptotic process (GO:0060544)2.72573293
38response to laminar fluid shear stress (GO:0034616)2.72447423
39histone H3-K9 modification (GO:0061647)2.71491301
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70222789
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69193334
42response to peptidoglycan (GO:0032494)2.68676867
43corticosteroid receptor signaling pathway (GO:0031958)2.66034695
44regulation of MHC class I biosynthetic process (GO:0045343)2.61130683
45glucocorticoid receptor signaling pathway (GO:0042921)2.60916714
46barbed-end actin filament capping (GO:0051016)2.59700178
47hemidesmosome assembly (GO:0031581)2.58571680
48detection of molecule of bacterial origin (GO:0032490)2.56843492
49response to epidermal growth factor (GO:0070849)2.54798079
50interkinetic nuclear migration (GO:0022027)2.54374366
51B cell receptor signaling pathway (GO:0050853)2.52812878
52modulation by symbiont of host cellular process (GO:0044068)2.52560308
53activation of Rac GTPase activity (GO:0032863)2.51862766
54negative regulation of cell size (GO:0045792)2.51824446
55histone lysine methylation (GO:0034968)2.50907953
56response to fluid shear stress (GO:0034405)2.50000283
57positive thymic T cell selection (GO:0045059)2.47486987
58endothelial cell chemotaxis (GO:0035767)2.46068844
59macrophage activation involved in immune response (GO:0002281)2.45827358
60regulation of ARF protein signal transduction (GO:0032012)2.44826988
61regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44660984
62positive regulation of protein kinase C signaling (GO:0090037)2.44533133
63modulation by virus of host process (GO:0019054)2.41143031
64regulation of nucleobase-containing compound transport (GO:0032239)2.38768525
65striated muscle atrophy (GO:0014891)2.36394513
66germinal center formation (GO:0002467)2.35657241
67T cell selection (GO:0045058)2.34504493
68regulation of leukocyte degranulation (GO:0043300)2.33129245
69antigen processing and presentation of endogenous antigen (GO:0019883)2.31809921
70regulation of response to osmotic stress (GO:0047484)2.31807667
71skeletal muscle adaptation (GO:0043501)2.31461232
72protein dealkylation (GO:0008214)2.31340954
73protein demethylation (GO:0006482)2.31340954
74low-density lipoprotein particle clearance (GO:0034383)2.30417696
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30273734
76positive regulation by organism of defense response of other organism involved in symbiotic interact2.30273734
77modulation by symbiont of host immune response (GO:0052553)2.30273734
78positive regulation by symbiont of host defense response (GO:0052509)2.30273734
79modulation by symbiont of host defense response (GO:0052031)2.30273734
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30273734
81regulation of RNA export from nucleus (GO:0046831)2.30255143
82regulation of histone H3-K27 methylation (GO:0061085)2.29885242
83N-terminal protein amino acid acetylation (GO:0006474)2.29818718
84activation of JUN kinase activity (GO:0007257)2.29248525
85detection of bacterium (GO:0016045)2.27586015
86positive regulation of blood vessel endothelial cell migration (GO:0043536)2.27479468
87peptidyl-lysine dimethylation (GO:0018027)2.27209436
88regulation of granulocyte differentiation (GO:0030852)2.27069816
89negative regulation of viral release from host cell (GO:1902187)2.27016138
90detection of other organism (GO:0098543)2.26124198
91cellular extravasation (GO:0045123)2.25292970
92intracellular estrogen receptor signaling pathway (GO:0030520)2.24961827
93megakaryocyte development (GO:0035855)2.23625166
94regulation of mast cell degranulation (GO:0043304)2.23624799
95positive regulation of granulocyte differentiation (GO:0030854)2.22741342
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.22705411
97detection of external biotic stimulus (GO:0098581)2.22526241
98CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.21891172
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21378095
100cell volume homeostasis (GO:0006884)2.21208858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.47026682
2MYC_22102868_ChIP-Seq_BL_Human3.23515384
3KDM2B_26808549_Chip-Seq_SUP-B15_Human3.06061545
4KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.71855424
5LXR_22292898_ChIP-Seq_THP-1_Human2.57378433
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55652216
7TCF7_22412390_ChIP-Seq_EML_Mouse2.53597207
8KDM2B_26808549_Chip-Seq_DND41_Human2.51510319
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.46138208
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.44890833
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.40854999
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.33582263
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30508677
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.28947613
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.27375600
16SCL_19346495_ChIP-Seq_HPC-7_Human2.23880075
17VDR_24763502_ChIP-Seq_THP-1_Human2.22358476
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13699590
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13518830
20RACK7_27058665_Chip-Seq_MCF-7_Human2.07352776
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06090106
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00369083
23KDM2B_26808549_Chip-Seq_K562_Human1.98938111
24MAF_26560356_Chip-Seq_TH1_Human1.98685837
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.95140632
26DROSHA_22980978_ChIP-Seq_HELA_Human1.93013768
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92896689
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.90438366
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.82409199
30KDM2B_26808549_Chip-Seq_JURKAT_Human1.81351292
31MAF_26560356_Chip-Seq_TH2_Human1.79263175
32GATA1_22025678_ChIP-Seq_K562_Human1.77206433
33GATA1_19941826_ChIP-Seq_K562_Human1.74407566
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.73506175
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72191616
36SPI1_23127762_ChIP-Seq_K562_Human1.67207444
37P68_20966046_ChIP-Seq_HELA_Human1.66591554
38UTX_26944678_Chip-Seq_JUKART_Human1.66507570
39GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63416169
40SMC4_20622854_ChIP-Seq_HELA_Human1.62276496
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55537501
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.54320365
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49218578
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.49029025
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49010078
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45968353
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45637413
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42096821
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42007116
50CREB1_26743006_Chip-Seq_LNCaP_Human1.40627003
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39171182
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38088553
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38034050
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35822546
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35096603
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34631334
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.34472424
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33280881
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30787272
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29983023
61BCOR_27268052_Chip-Seq_Bcells_Human1.29805283
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28118207
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.27347920
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25655513
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24882979
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23764504
67TP53_22127205_ChIP-Seq_IMR90_Human1.22048756
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21517428
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21341211
70NCOR1_26117541_ChIP-Seq_K562_Human1.20885853
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19890131
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19055635
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18442067
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18050922
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17963932
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15989760
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14462819
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.13800036
79CTCF_27219007_Chip-Seq_Bcells_Human1.12793774
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12357614
81TP63_22573176_ChIP-Seq_HFKS_Human1.11822373
82RUNX_20019798_ChIP-Seq_JUKART_Human1.11014304
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09308997
84MYB_26560356_Chip-Seq_TH1_Human1.08419338
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.07513471
86GATA2_19941826_ChIP-Seq_K562_Human1.07319707
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.06854137
88BCL6_27268052_Chip-Seq_Bcells_Human1.04815637
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04622609
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04445871
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04218420
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02272306
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.00368519
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.00053718
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99932630
96OCT4_19829295_ChIP-Seq_ESCs_Human0.97205624
97PHF8_20622854_ChIP-Seq_HELA_Human0.95907465
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95429451
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94324060
100E2F1_20622854_ChIP-Seq_HELA_Human0.94055482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.20746362
2MP0005076_abnormal_cell_differentiation3.28050678
3MP0003303_peritoneal_inflammation3.02011515
4MP0009278_abnormal_bone_marrow2.69924627
5MP0005451_abnormal_body_composition2.59910802
6MP0003091_abnormal_cell_migration2.58227838
7MP0005409_darkened_coat_color2.54863939
8MP0003763_abnormal_thymus_physiology2.32988093
9MP0004233_abnormal_muscle_weight2.15414824
10MP0005058_abnormal_lysosome_morphology2.09422942
11MP0001849_ear_inflammation2.06527601
12MP0009840_abnormal_foam_cell2.01341917
13MP0004808_abnormal_hematopoietic_stem1.98482365
14MP0003436_decreased_susceptibility_to1.98324243
15MP0000465_gastrointestinal_hemorrhage1.97282168
16MP0003172_abnormal_lysosome_physiology1.95137078
17MP0008004_abnormal_stomach_pH1.88670075
18MP0003045_fibrosis1.85971067
19MP0003279_aneurysm1.84239837
20MP0002249_abnormal_larynx_morphology1.81956002
21MP0003300_gastrointestinal_ulcer1.69353088
22MP0004381_abnormal_hair_follicle1.69132449
23MP0003453_abnormal_keratinocyte_physiol1.67092527
24MP0001545_abnormal_hematopoietic_system1.63533551
25MP0005397_hematopoietic_system_phenotyp1.63533551
26MP0003566_abnormal_cell_adhesion1.63477967
27MP0003656_abnormal_erythrocyte_physiolo1.57902551
28MP0001835_abnormal_antigen_presentation1.54048578
29MP0000733_abnormal_muscle_development1.52003659
30MP0008260_abnormal_autophagy1.50357852
31MP0004947_skin_inflammation1.50156792
32MP0000685_abnormal_immune_system1.49137563
33MP0005083_abnormal_biliary_tract1.43251568
34MP0004510_myositis1.41545758
35MP0003879_abnormal_hair_cell1.40611370
36MP0002396_abnormal_hematopoietic_system1.38304536
37MP0000747_muscle_weakness1.35825860
38MP0000678_abnormal_parathyroid_gland1.34901119
39MP0001800_abnormal_humoral_immune1.34629748
40MP0001790_abnormal_immune_system1.31519692
41MP0005387_immune_system_phenotype1.31519692
42MP0000751_myopathy1.29521870
43MP0002998_abnormal_bone_remodeling1.27323815
44MP0003183_abnormal_peptide_metabolism1.26257525
45MP0003828_pulmonary_edema1.24287053
46MP0010155_abnormal_intestine_physiology1.23560194
47MP0002419_abnormal_innate_immunity1.23520191
48MP0002398_abnormal_bone_marrow1.20544743
49MP0005025_abnormal_response_to1.19464079
50MP0000759_abnormal_skeletal_muscle1.18197372
51MP0000703_abnormal_thymus_morphology1.14482893
52MP0001661_extended_life_span1.13267806
53MP0005621_abnormal_cell_physiology1.12368537
54MP0002452_abnormal_antigen_presenting1.10786725
55MP0002405_respiratory_system_inflammati1.08539468
56MP0003866_abnormal_defecation1.07899046
57MP0001958_emphysema1.07668443
58MP0010368_abnormal_lymphatic_system1.07606463
59MP0002420_abnormal_adaptive_immunity1.06932181
60MP0001819_abnormal_immune_cell1.04566090
61MP0005257_abnormal_intraocular_pressure1.03873467
62MP0005000_abnormal_immune_tolerance1.03671000
63MP0008438_abnormal_cutaneous_collagen1.02824858
64MP0004130_abnormal_muscle_cell1.02272101
65MP0003136_yellow_coat_color1.00767442
66MP0002723_abnormal_immune_serum0.99145068
67MP0002722_abnormal_immune_system0.98159254
68MP0001348_abnormal_lacrimal_gland0.97050071
69MP0001851_eye_inflammation0.96090203
70MP0000716_abnormal_immune_system0.95565489
71MP0005275_abnormal_skin_tensile0.91908138
72MP0002060_abnormal_skin_morphology0.91610562
73MP0005174_abnormal_tail_pigmentation0.91166444
74MP0009931_abnormal_skin_appearance0.88571860
75MP0000767_abnormal_smooth_muscle0.88371007
76MP0004087_abnormal_muscle_fiber0.86705423
77MP0005310_abnormal_salivary_gland0.86435466
78MP0001986_abnormal_taste_sensitivity0.85343663
79MP0005023_abnormal_wound_healing0.84483810
80MP0002429_abnormal_blood_cell0.84261795
81MP0000003_abnormal_adipose_tissue0.83723364
82MP0004185_abnormal_adipocyte_glucose0.83521766
83MP0000015_abnormal_ear_pigmentation0.81871280
84MP0009333_abnormal_splenocyte_physiolog0.81222643
85MP0005666_abnormal_adipose_tissue0.80798070
86MP0002896_abnormal_bone_mineralization0.79883520
87MP0000579_abnormal_nail_morphology0.79359668
88MP0001533_abnormal_skeleton_physiology0.78544010
89MP0008961_abnormal_basal_metabolism0.77545381
90MP0000689_abnormal_spleen_morphology0.77120493
91MP0005464_abnormal_platelet_physiology0.76428569
92MP0003191_abnormal_cellular_cholesterol0.76318903
93MP0004036_abnormal_muscle_relaxation0.76165111
94MP0005171_absent_coat_pigmentation0.75899207
95MP0010630_abnormal_cardiac_muscle0.75515667
96MP0001915_intracranial_hemorrhage0.74997027
97MP0005375_adipose_tissue_phenotype0.72663046
98MP0002925_abnormal_cardiovascular_devel0.72612973
99MP0002933_joint_inflammation0.72473130
100MP0000858_altered_metastatic_potential0.72344088

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.59899361
2Abnormality of the columella (HP:0009929)3.97854300
3Broad face (HP:0000283)3.88365639
4Thin bony cortex (HP:0002753)3.52339157
5Cerebral aneurysm (HP:0004944)3.31608619
6Obstructive sleep apnea (HP:0002870)3.30882375
7Long eyelashes (HP:0000527)3.12671971
8Hyperacusis (HP:0010780)2.93403686
9Hemorrhage of the eye (HP:0011885)2.81943158
10Colitis (HP:0002583)2.63229016
11Dysmetric saccades (HP:0000641)2.54954190
12Distal lower limb amyotrophy (HP:0008944)2.51375065
13Ulnar bowing (HP:0003031)2.48965313
14Urethral obstruction (HP:0000796)2.46854097
15Autoimmune thrombocytopenia (HP:0001973)2.37914278
16Dislocated radial head (HP:0003083)2.37106821
17Lip pit (HP:0100267)2.33844515
18Increased connective tissue (HP:0009025)2.32939110
19Spondylolisthesis (HP:0003302)2.30785939
20Self-mutilation (HP:0000742)2.22741596
21Mask-like facies (HP:0000298)2.22509232
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16889696
23Abnormality of the distal phalanx of the thumb (HP:0009617)2.16853983
24Cellulitis (HP:0100658)2.15896780
25Annular pancreas (HP:0001734)2.14201895
26Abnormality of the radial head (HP:0003995)2.12065832
27Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.11364282
28Sparse lateral eyebrow (HP:0005338)2.10258332
29Centrally nucleated skeletal muscle fibers (HP:0003687)2.09734975
30Genetic anticipation (HP:0003743)2.08700550
31Aneurysm (HP:0002617)2.08089799
32Prominent nose (HP:0000448)2.06905132
33Distal upper limb amyotrophy (HP:0007149)2.02944431
34Upper limb amyotrophy (HP:0009129)2.02944431
35Malnutrition (HP:0004395)2.02757087
36Disproportionate tall stature (HP:0001519)2.01774808
37Emphysema (HP:0002097)2.01608391
38Thoracic kyphosis (HP:0002942)2.01522406
39Aortic aneurysm (HP:0004942)2.00114889
40Atrophic scars (HP:0001075)1.99386671
41Gastrointestinal inflammation (HP:0004386)1.99037821
42Narrow palate (HP:0000189)1.97420699
43Natal tooth (HP:0000695)1.92832871
44Flat occiput (HP:0005469)1.92498348
45Inflammation of the large intestine (HP:0002037)1.91902522
46Abnormality of the thoracic spine (HP:0100711)1.91135930
47Genu recurvatum (HP:0002816)1.86666775
48Eczematoid dermatitis (HP:0000976)1.85826581
49Mitral valve prolapse (HP:0001634)1.85371322
50Increased cerebral lipofuscin (HP:0011813)1.83686676
51Flat acetabular roof (HP:0003180)1.82470879
52Depressed nasal tip (HP:0000437)1.81857618
53Milia (HP:0001056)1.80769153
54Fragile skin (HP:0001030)1.80141761
55Cervical subluxation (HP:0003308)1.79792933
56Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76604890
57Abnormality of polysaccharide metabolism (HP:0011012)1.76604890
58Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76604890
59Prolonged bleeding time (HP:0003010)1.75093733
60Easy fatigability (HP:0003388)1.74728822
61Asymmetric septal hypertrophy (HP:0001670)1.72247644
62Long palpebral fissure (HP:0000637)1.71934048
63Tibial bowing (HP:0002982)1.71793640
64Intestinal fistula (HP:0100819)1.71461021
65Increased neuronal autofluorescent lipopigment (HP:0002074)1.70391662
66Thin ribs (HP:0000883)1.70231252
67Difficulty climbing stairs (HP:0003551)1.69717602
68Dysostosis multiplex (HP:0000943)1.68155720
69Urinary glycosaminoglycan excretion (HP:0003541)1.67762144
70Mucopolysacchariduria (HP:0008155)1.67762144
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.67083569
72Congenital hip dislocation (HP:0001374)1.65995112
73Facial hemangioma (HP:0000329)1.65757125
74Hypertriglyceridemia (HP:0002155)1.65714965
75Lower limb amyotrophy (HP:0007210)1.65586963
76Onion bulb formation (HP:0003383)1.64363365
77Protrusio acetabuli (HP:0003179)1.63778159
78Laryngomalacia (HP:0001601)1.63134819
79Tented upper lip vermilion (HP:0010804)1.62486702
80Mildly elevated creatine phosphokinase (HP:0008180)1.62470087
81Short chin (HP:0000331)1.60829950
82Abnormal cortical bone morphology (HP:0003103)1.60428381
83Increased variability in muscle fiber diameter (HP:0003557)1.58038677
84Ulnar deviation of the wrist (HP:0003049)1.56791332
85Ankyloglossia (HP:0010296)1.53460064
86Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.52870105
87Abnormality of the aortic arch (HP:0012303)1.52523467
88Enlarged epiphyses (HP:0010580)1.51593559
89Hyperkalemia (HP:0002153)1.51473873
90Joint laxity (HP:0001388)1.51410741
91Dilatation of the ascending aorta (HP:0005111)1.50849388
92Spontaneous hematomas (HP:0007420)1.49362114
93Ureteral stenosis (HP:0000071)1.48358648
94Hypoplasia of the iris (HP:0007676)1.48209530
95Increased IgE level (HP:0003212)1.47245618
96Germ cell neoplasia (HP:0100728)1.47134277
97Short nail (HP:0001799)1.47101893
98Exercise-induced myalgia (HP:0003738)1.46996611
99Abnormality of the nasal mucosa (HP:0000433)1.46497847
100Macroorchidism (HP:0000053)1.46158595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.57790368
2CDK124.35070497
3PRPF4B3.16822448
4ERN12.96181947
5ICK2.84247482
6EEF2K2.38083689
7SIK12.29887564
8MST1R2.06731270
9RIPK12.05236295
10CDC42BPA1.88114665
11BLK1.86908668
12MAP3K101.83245530
13PKN21.83201991
14MAP2K31.81608422
15MARK21.78368016
16CAMK1D1.70547886
17SMG11.68708835
18SIK21.59689362
19TTN1.59590476
20MTOR1.52437313
21MAP4K11.52287890
22ZAP701.49292448
23PRKD21.44704047
24BRD41.27943180
25MAPK151.26366841
26MAP3K71.26126913
27MAP3K131.22285424
28RIPK41.19539083
29CAMK1G1.13070581
30BTK1.10236054
31WNK11.07111375
32MAPK111.03058445
33IRAK31.00968821
34FGFR41.00443179
35TNK20.97967273
36TAOK10.93515794
37MELK0.92620090
38PTK60.90710786
39RPS6KA20.89419756
40EPHB10.89004231
41BMX0.87734119
42INSRR0.87137710
43TAOK20.85208212
44TYK20.84651102
45FES0.84209850
46PDGFRA0.83580477
47HIPK20.83015276
48RPS6KC10.82769388
49RPS6KL10.82769388
50NEK20.82097425
51TRPM70.81721810
52PDPK10.80216038
53MAP3K30.78967225
54MAPK120.78542940
55DDR20.77158322
56SGK30.77028796
57AKT30.76516816
58MARK30.74956256
59TBK10.74009220
60WNK40.73597509
61HCK0.72695788
62MAP3K10.72327214
63RPS6KA60.71604112
64JAK10.70335411
65RET0.69771070
66PDGFRB0.68940289
67MAP3K140.68686310
68PRKCH0.68200650
69CAMKK10.67211421
70CHUK0.67132951
71TESK20.65114037
72MAP3K60.64845534
73CDK40.64177969
74IRAK40.64171487
75CSK0.60941882
76CAMK40.60008389
77GRK60.58748010
78MET0.54765230
79MAP2K60.54261997
80PDK10.54057660
81NME10.52132046
82CSF1R0.52063968
83SIK30.51632688
84FGFR30.51540177
85JAK30.50421945
86SGK20.50303848
87NLK0.49478073
88TYRO30.48264311
89SYK0.47867526
90PRKAA20.47299168
91MAPK70.46802445
92PRKAA10.42626523
93IRAK20.40631575
94STK380.40286040
95JAK20.39070033
96PIK3CG0.37961513
97TGFBR20.37262284
98NTRK10.37029218
99CDK190.36832923
100MAPK80.36783354

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.12095528
2Notch signaling pathway_Homo sapiens_hsa043301.92691268
3Other glycan degradation_Homo sapiens_hsa005111.88049183
4B cell receptor signaling pathway_Homo sapiens_hsa046621.84295107
5Chronic myeloid leukemia_Homo sapiens_hsa052201.82379961
6Lysine degradation_Homo sapiens_hsa003101.72151183
7Osteoclast differentiation_Homo sapiens_hsa043801.56389011
8Non-small cell lung cancer_Homo sapiens_hsa052231.56115039
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.49896227
10VEGF signaling pathway_Homo sapiens_hsa043701.43569504
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43384874
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41173709
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33497554
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32814185
15TNF signaling pathway_Homo sapiens_hsa046681.28229606
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28106950
17mTOR signaling pathway_Homo sapiens_hsa041501.27948993
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.27529517
19Endometrial cancer_Homo sapiens_hsa052131.20308877
20Pancreatic cancer_Homo sapiens_hsa052121.19281872
21Toxoplasmosis_Homo sapiens_hsa051451.17459222
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16787232
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.15680593
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15543286
25Hepatitis B_Homo sapiens_hsa051611.15058186
26Platelet activation_Homo sapiens_hsa046111.14428482
27Inositol phosphate metabolism_Homo sapiens_hsa005621.14313502
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13042640
29Influenza A_Homo sapiens_hsa051641.12909326
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10746898
31Small cell lung cancer_Homo sapiens_hsa052221.10577286
32Prostate cancer_Homo sapiens_hsa052151.08840964
33GnRH signaling pathway_Homo sapiens_hsa049121.08339728
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07042372
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05364849
36Bladder cancer_Homo sapiens_hsa052191.05127964
37Glioma_Homo sapiens_hsa052141.04836651
38Estrogen signaling pathway_Homo sapiens_hsa049151.04825550
39Choline metabolism in cancer_Homo sapiens_hsa052311.04666827
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.04629421
41T cell receptor signaling pathway_Homo sapiens_hsa046601.04138035
42Focal adhesion_Homo sapiens_hsa045101.03324660
43Insulin resistance_Homo sapiens_hsa049311.02850274
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02397573
45ErbB signaling pathway_Homo sapiens_hsa040121.01609229
46Apoptosis_Homo sapiens_hsa042101.00864196
47Leishmaniasis_Homo sapiens_hsa051401.00041601
48Renal cell carcinoma_Homo sapiens_hsa052110.99678163
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99355262
50ABC transporters_Homo sapiens_hsa020100.95637788
51MicroRNAs in cancer_Homo sapiens_hsa052060.95314433
52ECM-receptor interaction_Homo sapiens_hsa045120.94811469
53Hepatitis C_Homo sapiens_hsa051600.94753810
54Prolactin signaling pathway_Homo sapiens_hsa049170.92217660
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91788764
56Amoebiasis_Homo sapiens_hsa051460.91493051
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.90785460
58Measles_Homo sapiens_hsa051620.89899761
59Malaria_Homo sapiens_hsa051440.87518903
60FoxO signaling pathway_Homo sapiens_hsa040680.87477713
61Type II diabetes mellitus_Homo sapiens_hsa049300.86889276
62Tuberculosis_Homo sapiens_hsa051520.85031830
63Insulin signaling pathway_Homo sapiens_hsa049100.84820679
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.83578305
65Viral carcinogenesis_Homo sapiens_hsa052030.83399181
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82444940
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82072793
68Herpes simplex infection_Homo sapiens_hsa051680.80964308
69HTLV-I infection_Homo sapiens_hsa051660.80894348
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80602028
71MAPK signaling pathway_Homo sapiens_hsa040100.79668895
72Colorectal cancer_Homo sapiens_hsa052100.79100767
73Fructose and mannose metabolism_Homo sapiens_hsa000510.76138816
74Thyroid cancer_Homo sapiens_hsa052160.75207003
75Proteoglycans in cancer_Homo sapiens_hsa052050.75079214
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74553506
77Primary immunodeficiency_Homo sapiens_hsa053400.74445247
78Dorso-ventral axis formation_Homo sapiens_hsa043200.74296341
79Adherens junction_Homo sapiens_hsa045200.73233274
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.70974574
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.70866572
82Lysosome_Homo sapiens_hsa041420.68449493
83Hematopoietic cell lineage_Homo sapiens_hsa046400.68140963
84Staphylococcus aureus infection_Homo sapiens_hsa051500.67848998
85AMPK signaling pathway_Homo sapiens_hsa041520.67056698
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65770474
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.62433232
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61384133
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60539103
90Long-term potentiation_Homo sapiens_hsa047200.60275409
91Pathways in cancer_Homo sapiens_hsa052000.59891865
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.59452359
93Cholinergic synapse_Homo sapiens_hsa047250.58807286
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58103410
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58044555
96Chemokine signaling pathway_Homo sapiens_hsa040620.57828347
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57108864
98Dilated cardiomyopathy_Homo sapiens_hsa054140.55678567
99HIF-1 signaling pathway_Homo sapiens_hsa040660.55528231
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53981501

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