NUSAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.89260855
2protein localization to chromosome, centromeric region (GO:0071459)6.16601648
3* mitotic sister chromatid segregation (GO:0000070)6.00252233
4kinetochore organization (GO:0051383)5.87043534
5mitotic metaphase plate congression (GO:0007080)5.84377886
6* sister chromatid segregation (GO:0000819)5.75784545
7* mitotic chromosome condensation (GO:0007076)5.56654640
8attachment of spindle microtubules to kinetochore (GO:0008608)5.47393468
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.37552941
10metaphase plate congression (GO:0051310)5.35752934
11establishment of chromosome localization (GO:0051303)5.06958768
12kinetochore assembly (GO:0051382)4.96155852
13CENP-A containing nucleosome assembly (GO:0034080)4.93999521
14DNA unwinding involved in DNA replication (GO:0006268)4.88510602
15regulation of spindle organization (GO:0090224)4.85554714
16chromatin remodeling at centromere (GO:0031055)4.84338898
17meiotic chromosome segregation (GO:0045132)4.68419817
18DNA replication-independent nucleosome organization (GO:0034724)4.48113895
19DNA replication-independent nucleosome assembly (GO:0006336)4.48113895
20DNA replication-dependent nucleosome organization (GO:0034723)4.38602788
21DNA replication-dependent nucleosome assembly (GO:0006335)4.38602788
22regulation of mitotic spindle organization (GO:0060236)4.36395722
23spindle checkpoint (GO:0031577)4.35424282
24protein localization to chromosome (GO:0034502)4.34097044
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.32921158
26mitotic nuclear envelope disassembly (GO:0007077)4.29805494
27nuclear pore organization (GO:0006999)4.27816124
28nuclear pore complex assembly (GO:0051292)4.23555467
29regulation of chromosome segregation (GO:0051983)4.23106884
30DNA replication checkpoint (GO:0000076)4.21757819
31positive regulation of chromosome segregation (GO:0051984)4.21331916
32positive regulation of mitotic sister chromatid separation (GO:1901970)4.19582298
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.19582298
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.19582298
35histone exchange (GO:0043486)4.17513339
36spindle assembly checkpoint (GO:0071173)4.14108527
37* chromosome segregation (GO:0007059)4.12350181
38DNA strand elongation involved in DNA replication (GO:0006271)4.11266078
39establishment of integrated proviral latency (GO:0075713)4.10692712
40mitotic sister chromatid cohesion (GO:0007064)4.01702160
41DNA replication initiation (GO:0006270)4.00846876
42negative regulation of chromosome segregation (GO:0051985)4.00512635
43nuclear envelope disassembly (GO:0051081)3.99711603
44membrane disassembly (GO:0030397)3.99711603
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.97448748
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.97168201
47negative regulation of sister chromatid segregation (GO:0033046)3.97168201
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.97168201
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.97168201
50mitotic recombination (GO:0006312)3.95977948
51mitotic spindle assembly checkpoint (GO:0007094)3.91964160
52microtubule depolymerization (GO:0007019)3.91067127
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.89929015
54DNA strand elongation (GO:0022616)3.89612824
55telomere maintenance via semi-conservative replication (GO:0032201)3.88509877
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.87445033
57mitotic spindle checkpoint (GO:0071174)3.86123580
58DNA topological change (GO:0006265)3.85645159
59regulation of sister chromatid cohesion (GO:0007063)3.84601626
60regulation of mitotic sister chromatid separation (GO:0010965)3.82938827
61regulation of mitotic sister chromatid segregation (GO:0033047)3.82938827
62regulation of sister chromatid segregation (GO:0033045)3.82938827
63* chromosome condensation (GO:0030261)3.82100770
64chromatin assembly or disassembly (GO:0006333)3.81926580
65regulation of DNA endoreduplication (GO:0032875)3.75934662
66regulation of telomere maintenance via telomerase (GO:0032210)3.75496795
67telomere maintenance via recombination (GO:0000722)3.65752835
68DNA duplex unwinding (GO:0032508)3.53129754
69DNA geometric change (GO:0032392)3.52837809
70resolution of meiotic recombination intermediates (GO:0000712)3.52719255
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47951152
72ATP-dependent chromatin remodeling (GO:0043044)3.47585758
73regulation of centrosome cycle (GO:0046605)3.46812713
74double-strand break repair via nonhomologous end joining (GO:0006303)3.46611123
75non-recombinational repair (GO:0000726)3.46611123
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.40452427
77replication fork processing (GO:0031297)3.39382428
78microtubule polymerization or depolymerization (GO:0031109)3.39302641
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38109282
80negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.35231775
81* DNA packaging (GO:0006323)3.34739293
82* DNA conformation change (GO:0071103)3.31918773
83DNA strand renaturation (GO:0000733)3.31216565
84centriole replication (GO:0007099)3.31090047
85DNA double-strand break processing (GO:0000729)3.30928502
86telomere maintenance via telomere lengthening (GO:0010833)3.28430554
87regulation of exit from mitosis (GO:0007096)3.25234618
88ventricular cardiac muscle cell development (GO:0055015)3.24688419
89mitotic G2/M transition checkpoint (GO:0044818)3.24291969
90negative regulation of cell division (GO:0051782)3.22863944
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22672552
92negative regulation of cell cycle G2/M phase transition (GO:1902750)3.21352057
93regulation of histone H3-K9 methylation (GO:0051570)3.20301298
94nucleotide-excision repair, DNA gap filling (GO:0006297)3.18921236
95pore complex assembly (GO:0046931)3.18289486
96DNA ligation (GO:0006266)3.17905169
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17847226
98negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.16076605
99regulation of double-strand break repair via homologous recombination (GO:0010569)3.13737890
100negative regulation of nuclear division (GO:0051784)3.13534448
101mitotic cell cycle (GO:0000278)3.12967516
102mitotic spindle organization (GO:0007052)3.12624230
103negative regulation of DNA-dependent DNA replication (GO:2000104)3.11997644
104negative regulation of mitosis (GO:0045839)3.10974153
105spindle assembly involved in mitosis (GO:0090307)3.07573904
106nuclear envelope organization (GO:0006998)3.06800094
107regulation of centriole replication (GO:0046599)3.05513257
108chromatin assembly (GO:0031497)3.04065191
109protein K6-linked ubiquitination (GO:0085020)3.01096013
110histone-serine phosphorylation (GO:0035404)2.96769677
111formation of translation preinitiation complex (GO:0001731)2.93330275
112regulation of double-strand break repair (GO:2000779)2.92471871
113negative regulation of telomerase activity (GO:0051974)2.91169369
114* chromosome organization (GO:0051276)2.91141721
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.90907652
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90907652
117mitotic DNA integrity checkpoint (GO:0044774)2.90702103
118mitotic nuclear division (GO:0007067)2.88439669
119mitotic cell cycle checkpoint (GO:0007093)2.88218202
120ribosomal small subunit assembly (GO:0000028)2.87031820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human7.99486132
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.09349499
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.78885547
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.37871831
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84977799
6AR_21909140_ChIP-Seq_LNCAP_Human2.84705121
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.77446720
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57159437
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51642496
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37985047
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.31412980
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.30662311
13* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.27488130
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.27449448
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17184806
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15857848
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11059324
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07384551
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04479824
20XRN2_22483619_ChIP-Seq_HELA_Human2.00522963
21E2F7_22180533_ChIP-Seq_HELA_Human10.3629763
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87375377
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.84586624
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83966219
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83531324
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.82116249
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82016599
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80218311
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.77345093
30VDR_23849224_ChIP-Seq_CD4+_Human1.72469609
31FOXP3_21729870_ChIP-Seq_TREG_Human1.71852568
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67807772
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66000058
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60192361
35MYC_22102868_ChIP-Seq_BL_Human1.58256316
36TTF2_22483619_ChIP-Seq_HELA_Human1.57328626
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56304745
38CIITA_25753668_ChIP-Seq_RAJI_Human1.55805111
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53324016
40DCP1A_22483619_ChIP-Seq_HELA_Human1.51580000
41ELK1_19687146_ChIP-ChIP_HELA_Human1.48059402
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43754426
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43222069
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36631340
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36119209
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34147678
47KDM5A_27292631_Chip-Seq_BREAST_Human1.33902731
48GABP_19822575_ChIP-Seq_HepG2_Human1.32593652
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32139708
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.25942923
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24628103
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24628103
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24628103
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24466129
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23445400
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23244536
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22731398
58* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22537812
59* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18396314
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.18391032
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17713166
62* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15865900
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15852070
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14640569
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13974243
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12431103
67* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09966727
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07047340
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.06920114
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05260619
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03343618
72* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02109891
73EWS_26573619_Chip-Seq_HEK293_Human1.02001153
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00384398
75YY1_21170310_ChIP-Seq_MESCs_Mouse0.99166479
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97920711
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96806309
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95639440
79MYC_18940864_ChIP-ChIP_HL60_Human0.94515892
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94086275
81* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93327930
82SOX17_20123909_ChIP-Seq_XEN_Mouse0.93056786
83TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91361231
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90264203
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89842670
86VDR_21846776_ChIP-Seq_THP-1_Human0.88725958
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88195861
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88036188
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87319990
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85847711
91RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85511553
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85339038
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82442569
94TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82066358
95TFEB_21752829_ChIP-Seq_HELA_Human0.81310781
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80944970
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80493670
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78638496
99IRF1_19129219_ChIP-ChIP_H3396_Human0.77469373
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76422074
101FUS_26573619_Chip-Seq_HEK293_Human0.76362178
102* SOX2_16153702_ChIP-ChIP_HESCs_Human0.76098005
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75292455
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74022927
105* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73233226
106SPI1_23547873_ChIP-Seq_NB4_Human0.73137662
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72979177
108* NANOG_16153702_ChIP-ChIP_HESCs_Human0.72827565
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71488956
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.65689192
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.64588857
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.61331321
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.61230260
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.60319566
115CHD1_26751641_Chip-Seq_LNCaP_Human0.59199571
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.58069020
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.57052549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.36154562
2MP0010094_abnormal_chromosome_stability4.97793004
3MP0003111_abnormal_nucleus_morphology4.86386702
4* MP0003077_abnormal_cell_cycle4.24381501
5* MP0004957_abnormal_blastocyst_morpholog4.18614832
6MP0008057_abnormal_DNA_replication4.05847559
7MP0008007_abnormal_cellular_replicative2.84545682
8MP0008058_abnormal_DNA_repair2.73455363
9MP0003123_paternal_imprinting2.54171103
10MP0000350_abnormal_cell_proliferation2.37223921
11* MP0008932_abnormal_embryonic_tissue2.35261405
12MP0009697_abnormal_copulation2.26589507
13MP0001730_embryonic_growth_arrest2.24541148
14MP0002396_abnormal_hematopoietic_system2.20860377
15MP0003121_genomic_imprinting2.15083118
16MP0010307_abnormal_tumor_latency2.06109963
17MP0001672_abnormal_embryogenesis/_devel1.97338888
18MP0005380_embryogenesis_phenotype1.97338888
19MP0008877_abnormal_DNA_methylation1.90305417
20MP0010352_gastrointestinal_tract_polyps1.89041364
21* MP0001697_abnormal_embryo_size1.73071707
22MP0003984_embryonic_growth_retardation1.72528804
23MP0002088_abnormal_embryonic_growth/wei1.69562574
24MP0010030_abnormal_orbit_morphology1.67189795
25MP0000490_abnormal_crypts_of1.66586473
26* MP0002085_abnormal_embryonic_tissue1.66244752
27MP0003890_abnormal_embryonic-extraembry1.65266182
28MP0003718_maternal_effect1.65060454
29MP0003136_yellow_coat_color1.62745266
30MP0000372_irregular_coat_pigmentation1.59359446
31MP0002086_abnormal_extraembryonic_tissu1.53769113
32MP0003315_abnormal_perineum_morphology1.53105563
33MP0002084_abnormal_developmental_patter1.51538214
34* MP0002080_prenatal_lethality1.51005664
35MP0003786_premature_aging1.50385670
36MP0000313_abnormal_cell_death1.47728509
37MP0004808_abnormal_hematopoietic_stem1.47021585
38MP0006292_abnormal_olfactory_placode1.46383683
39MP0002019_abnormal_tumor_incidence1.44486595
40MP0005076_abnormal_cell_differentiation1.40770247
41MP0004197_abnormal_fetal_growth/weight/1.39698329
42MP0004264_abnormal_extraembryonic_tissu1.39526869
43MP0003787_abnormal_imprinting1.37886441
44MP0001346_abnormal_lacrimal_gland1.32169483
45MP0002210_abnormal_sex_determination1.24068438
46MP0005171_absent_coat_pigmentation1.21616201
47MP0003705_abnormal_hypodermis_morpholog1.20275225
48MP0000566_synostosis1.20141759
49MP0002697_abnormal_eye_size1.18932285
50MP0001293_anophthalmia1.15061295
51MP0002234_abnormal_pharynx_morphology1.13504398
52MP0001929_abnormal_gametogenesis1.11728077
53MP0000703_abnormal_thymus_morphology1.10724332
54MP0001145_abnormal_male_reproductive1.08797762
55MP0003806_abnormal_nucleotide_metabolis1.08240048
56MP0003567_abnormal_fetal_cardiomyocyte1.05425635
57MP0003937_abnormal_limbs/digits/tail_de1.04082974
58MP0001529_abnormal_vocalization1.00808474
59MP0002233_abnormal_nose_morphology0.98512100
60MP0002398_abnormal_bone_marrow0.97914502
61MP0000653_abnormal_sex_gland0.97816554
62MP0001119_abnormal_female_reproductive0.96464983
63MP0006035_abnormal_mitochondrial_morpho0.96294445
64MP0006072_abnormal_retinal_apoptosis0.95904833
65MP0002722_abnormal_immune_system0.93319537
66MP0005397_hematopoietic_system_phenotyp0.92341536
67MP0001545_abnormal_hematopoietic_system0.92341536
68MP0000358_abnormal_cell_content/0.92086448
69MP0005408_hypopigmentation0.89906119
70MP0003763_abnormal_thymus_physiology0.87536780
71MP0006054_spinal_hemorrhage0.86799244
72MP0000689_abnormal_spleen_morphology0.85745149
73MP0002092_abnormal_eye_morphology0.85225703
74MP0009703_decreased_birth_body0.84879992
75MP0002932_abnormal_joint_morphology0.82912621
76MP0006036_abnormal_mitochondrial_physio0.82313987
77MP0009053_abnormal_anal_canal0.81073791
78MP0002111_abnormal_tail_morphology0.79881248
79MP0003698_abnormal_male_reproductive0.79442983
80MP0002653_abnormal_ependyma_morphology0.77877715
81MP0009672_abnormal_birth_weight0.77553045
82MP0000432_abnormal_head_morphology0.77395594
83MP0003119_abnormal_digestive_system0.77275601
84MP0002009_preneoplasia0.76081460
85MP0002102_abnormal_ear_morphology0.76028704
86MP0003938_abnormal_ear_development0.75654233
87MP0001286_abnormal_eye_development0.75581884
88MP0009333_abnormal_splenocyte_physiolog0.74292843
89MP0002877_abnormal_melanocyte_morpholog0.74200819
90MP0003935_abnormal_craniofacial_develop0.74172197
91MP0005391_vision/eye_phenotype0.73948769
92MP0000647_abnormal_sebaceous_gland0.73923230
93MP0001849_ear_inflammation0.73351967
94MP0003656_abnormal_erythrocyte_physiolo0.71952327
95MP0005023_abnormal_wound_healing0.71416042
96MP0005384_cellular_phenotype0.71329116
97MP0002429_abnormal_blood_cell0.71255620
98MP0003186_abnormal_redox_activity0.70764829
99MP0008995_early_reproductive_senescence0.69433839
100MP0000858_altered_metastatic_potential0.69344479
101MP0005621_abnormal_cell_physiology0.69097509
102MP0000428_abnormal_craniofacial_morphol0.68977040
103MP0005395_other_phenotype0.68558441
104MP0009278_abnormal_bone_marrow0.68039342
105MP0003699_abnormal_female_reproductive0.68033247
106MP0002161_abnormal_fertility/fecundity0.67937817
107MP0003941_abnormal_skin_development0.67839446
108MP0003755_abnormal_palate_morphology0.66869788
109MP0005389_reproductive_system_phenotype0.65835442
110MP0002925_abnormal_cardiovascular_devel0.65014419
111MP0005248_abnormal_Harderian_gland0.64882103
112MP0000049_abnormal_middle_ear0.63561280
113MP0002938_white_spotting0.63163640
114MP0003385_abnormal_body_wall0.63142718
115MP0005075_abnormal_melanosome_morpholog0.62967810
116MP0002114_abnormal_axial_skeleton0.62320105
117MP0001919_abnormal_reproductive_system0.61949993
118MP0004147_increased_porphyrin_level0.61132534
119MP0002095_abnormal_skin_pigmentation0.60955669
120MP0009379_abnormal_foot_pigmentation0.60756294
121MP0002160_abnormal_reproductive_system0.60308113
122MP0001915_intracranial_hemorrhage0.58056236
123MP0000537_abnormal_urethra_morphology0.57755799
124MP0000716_abnormal_immune_system0.57530255
125MP0003861_abnormal_nervous_system0.57107774
126MP0008789_abnormal_olfactory_epithelium0.56655540
127MP0003943_abnormal_hepatobiliary_system0.56373606
128MP0000383_abnormal_hair_follicle0.56320069
129MP0001727_abnormal_embryo_implantation0.56028947
130MP0000477_abnormal_intestine_morphology0.55910873
131MP0005499_abnormal_olfactory_system0.54904279
132MP0005394_taste/olfaction_phenotype0.54904279

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.34783075
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.22627698
3Meckel diverticulum (HP:0002245)3.71524810
4Abnormality of chromosome stability (HP:0003220)3.71078786
5Nephroblastoma (Wilms tumor) (HP:0002667)3.56168062
6Abnormality of the ileum (HP:0001549)3.52599555
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.52192869
8Volvulus (HP:0002580)3.50072535
9Duodenal stenosis (HP:0100867)3.47584473
10Small intestinal stenosis (HP:0012848)3.47584473
11Impulsivity (HP:0100710)3.46389952
12Abnormal lung lobation (HP:0002101)3.44664822
13Reticulocytopenia (HP:0001896)3.43540228
14Abnormality of the preputium (HP:0100587)3.42882571
15Increased nuchal translucency (HP:0010880)3.37060907
16Embryonal renal neoplasm (HP:0011794)3.31800923
17Colon cancer (HP:0003003)3.22358988
18Medulloblastoma (HP:0002885)3.21085250
19Birth length less than 3rd percentile (HP:0003561)3.19782154
20Rhabdomyosarcoma (HP:0002859)3.14092637
21Ependymoma (HP:0002888)3.13995681
22Patellar aplasia (HP:0006443)3.13830243
23Myelodysplasia (HP:0002863)3.08534096
24Hypochromic microcytic anemia (HP:0004840)2.97692863
25Aplasia/Hypoplasia of the patella (HP:0006498)2.91414062
26Sloping forehead (HP:0000340)2.86784091
27Abnormality of the duodenum (HP:0002246)2.78961640
28Breast hypoplasia (HP:0003187)2.70125987
29Carpal bone hypoplasia (HP:0001498)2.57759777
30Ectopic kidney (HP:0000086)2.57537282
31Neoplasm of striated muscle (HP:0009728)2.54211418
32Selective tooth agenesis (HP:0001592)2.51436917
33Absent radius (HP:0003974)2.51382376
34Abnormality of chromosome segregation (HP:0002916)2.51296852
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.49542392
36Abnormality of the labia minora (HP:0012880)2.47753134
37Supernumerary spleens (HP:0009799)2.47349878
38Cafe-au-lait spot (HP:0000957)2.40588287
39Abnormality of the carotid arteries (HP:0005344)2.40245395
40Oral leukoplakia (HP:0002745)2.37620703
41Atresia of the external auditory canal (HP:0000413)2.36775484
42Bone marrow hypocellularity (HP:0005528)2.32771238
43Absent forearm bone (HP:0003953)2.32327761
44Aplasia involving forearm bones (HP:0009822)2.32327761
45Aplastic anemia (HP:0001915)2.30076153
46Short 4th metacarpal (HP:0010044)2.28205792
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28205792
48Proximal placement of thumb (HP:0009623)2.24685286
4911 pairs of ribs (HP:0000878)2.20279569
50Absent thumb (HP:0009777)2.20062713
51Facial hemangioma (HP:0000329)2.19868481
52Deviation of the thumb (HP:0009603)2.19535856
53Triphalangeal thumb (HP:0001199)2.17546367
54Abnormal number of incisors (HP:0011064)2.17170423
55Abnormality of cells of the erythroid lineage (HP:0012130)2.16713726
56Astrocytoma (HP:0009592)2.16235753
57Abnormality of the astrocytes (HP:0100707)2.16235753
58Clubbing of toes (HP:0100760)2.15540730
59Tracheoesophageal fistula (HP:0002575)2.15003360
60Bilateral microphthalmos (HP:0007633)2.11930823
61Neoplasm of the colon (HP:0100273)2.11070113
62Abnormal number of erythroid precursors (HP:0012131)2.10727178
63Duplicated collecting system (HP:0000081)2.09572372
64Degeneration of anterior horn cells (HP:0002398)2.06578827
65Abnormality of the anterior horn cell (HP:0006802)2.06578827
66Multiple enchondromatosis (HP:0005701)2.05471305
67Hypoplastic pelvis (HP:0008839)2.03465262
68Abnormality of the heme biosynthetic pathway (HP:0010472)2.03145683
69Rib fusion (HP:0000902)2.01284316
70Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99211395
71Missing ribs (HP:0000921)1.99153521
72Agnosia (HP:0010524)1.99020640
73Prominent nose (HP:0000448)1.98597563
74Long clavicles (HP:0000890)1.98108984
75Duplication of thumb phalanx (HP:0009942)1.97126839
76Glioma (HP:0009733)1.96647548
77Abnormality of the renal collecting system (HP:0004742)1.96093669
78Short thumb (HP:0009778)1.95605268
79Cortical dysplasia (HP:0002539)1.93553035
80High pitched voice (HP:0001620)1.92356056
81Abnormality of DNA repair (HP:0003254)1.91425371
82Embryonal neoplasm (HP:0002898)1.91050575
83Neoplasm of the pancreas (HP:0002894)1.90872632
84Neoplasm of the oral cavity (HP:0100649)1.90528806
85Basal cell carcinoma (HP:0002671)1.88073580
86Deep philtrum (HP:0002002)1.86604956
87Combined immunodeficiency (HP:0005387)1.84721206
88Horseshoe kidney (HP:0000085)1.84243417
89Overlapping toe (HP:0001845)1.83712021
90Broad palm (HP:0001169)1.83117606
91Premature ovarian failure (HP:0008209)1.83067733
92Gastrointestinal carcinoma (HP:0002672)1.82588565
93Malignant gastrointestinal tract tumors (HP:0006749)1.82588565
94Irregular epiphyses (HP:0010582)1.80544999
95Pallor (HP:0000980)1.80506848
96Ovarian neoplasm (HP:0100615)1.79594538
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78864144
98Squamous cell carcinoma (HP:0002860)1.78043608
99Arteriovenous malformation (HP:0100026)1.77935960
100Microretrognathia (HP:0000308)1.77732138
101High anterior hairline (HP:0009890)1.77039855
102Cleft eyelid (HP:0000625)1.76864456
103Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76862509
104Short middle phalanx of the 5th finger (HP:0004220)1.76769657
105Holoprosencephaly (HP:0001360)1.76006883
106Acute necrotizing encephalopathy (HP:0006965)1.75626715
107Abdominal situs inversus (HP:0003363)1.75476748
108Abnormality of abdominal situs (HP:0011620)1.75476748
109Abnormality of glycolysis (HP:0004366)1.75403400
110Trismus (HP:0000211)1.74848795
111Abnormality of the septum pellucidum (HP:0007375)1.74472019
112Choanal atresia (HP:0000453)1.73101991
113Oligodactyly (hands) (HP:0001180)1.71239264
114Abnormality of cochlea (HP:0000375)1.70659623
115Renal duplication (HP:0000075)1.70056350
116Absent septum pellucidum (HP:0001331)1.69446918
117Broad distal phalanx of finger (HP:0009836)1.67116827
118Acute encephalopathy (HP:0006846)1.66554198
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64633313
120Abnormal mitochondria in muscle tissue (HP:0008316)1.64091345
121Increased hepatocellular lipid droplets (HP:0006565)1.62628400
122Increased serum pyruvate (HP:0003542)1.62238971
123Small hand (HP:0200055)1.60837236
124Oligodactyly (HP:0012165)1.59643011
125Microvesicular hepatic steatosis (HP:0001414)1.58748615
126Intestinal polyposis (HP:0200008)1.58729070
127Septo-optic dysplasia (HP:0100842)1.58152231
128Abnormality of the fetal cardiovascular system (HP:0010948)1.57611885
129Abnormal umbilical cord blood vessels (HP:0011403)1.57611885
130Single umbilical artery (HP:0001195)1.57611885
131Pancytopenia (HP:0001876)1.57216595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.31367630
2CDC74.55240734
3WEE13.85813801
4NEK23.76614529
5TTK3.58828432
6CDK123.56155105
7BRSK22.80528506
8VRK22.57960505
9PLK12.54547155
10NEK12.52635150
11STK102.47648296
12EIF2AK12.28082380
13BRSK12.26659274
14SRPK12.14521028
15* AURKB2.09512841
16CHEK22.04535416
17CCNB11.98949609
18PLK41.86844416
19STK41.75183196
20MELK1.72536451
21PLK31.69191943
22ACVR1B1.68004941
23TAF11.66876956
24TLK11.66007187
25CDK71.65239997
26CDK41.54838908
27AURKA1.54027036
28MAP3K81.54002069
29EEF2K1.53989681
30ATR1.53460796
31VRK11.47595374
32CHEK11.43906288
33RPS6KB21.38898923
34MAP3K101.33915346
35MKNK11.27644079
36PNCK1.21948367
37RPS6KA41.19212134
38DYRK31.14429521
39GRK61.13623125
40CDK61.10505673
41TRIM281.10424227
42PASK1.09529663
43TESK21.07825658
44PBK1.01703341
45MST40.98872606
46* ATM0.98815445
47PAK40.92017111
48CDK20.91214933
49STK30.90348415
50MKNK20.86799764
51EIF2AK20.83577375
52BRD40.83118186
53* CDK10.80774144
54SMG10.77376857
55EIF2AK30.75803466
56ZAK0.73138802
57CSF1R0.71666807
58CDK80.69651484
59PLK20.69467148
60PIM10.68695122
61PDK20.65938247
62BMPR1B0.65084872
63NME20.63329047
64SCYL20.61449510
65TGFBR10.61352601
66TSSK60.61019658
67PKN20.60717623
68CLK10.60697909
69LRRK20.57502922
70WNK30.56408513
71BRAF0.56262567
72TNIK0.54012115
73NME10.52925068
74PAK10.50864770
75CDK90.50508193
76BCR0.48489207
77FLT30.47826078
78AKT20.45992161
79LATS10.44365775
80CSNK2A10.43538311
81CDK30.42294803
82ERBB30.42082680
83MAP4K10.40035103
84MARK30.39995145
85STK160.39704655
86ALK0.38678904
87CDK140.37331114
88CSNK2A20.36170274
89ERBB40.34859755
90MTOR0.34547912
91UHMK10.33492840
92PRKCI0.32935344
93RPS6KA50.32623990
94EPHA20.32612000
95MAPK140.31422667
96MAPKAPK30.30341228
97MAPK110.29443993
98PRKDC0.28827983
99AKT10.26568228
100MINK10.26277449
101CSNK1G10.25161386
102CSNK1G30.24656247
103YES10.24618830
104DYRK20.24178781
105DYRK1B0.24109084
106FGFR10.23237753
107MAPKAPK20.22962199
108MAPKAPK50.21944813
109ERBB20.21778301
110PKN10.21760170
111MST1R0.21381533
112MAPK10.20495366
113CSNK1E0.20277499
114CSNK1D0.20245840
115GSK3B0.19137133
116NUAK10.18217147
117STK38L0.17961306
118CDK11A0.17461858
119CDK150.17352768
120GRK50.16049231
121NEK90.15678431
122CDK180.15426374
123MOS0.15028943
124MET0.14727826
125STK390.14332341
126CHUK0.14138090
127CSNK1A1L0.14007015
128TESK10.13109028

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88690518
2Mismatch repair_Homo sapiens_hsa034304.31868400
3Cell cycle_Homo sapiens_hsa041103.77771632
4Homologous recombination_Homo sapiens_hsa034403.47867113
5Base excision repair_Homo sapiens_hsa034103.26493456
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19881935
7Spliceosome_Homo sapiens_hsa030403.11241572
8RNA transport_Homo sapiens_hsa030133.07313552
9Fanconi anemia pathway_Homo sapiens_hsa034602.94802225
10Nucleotide excision repair_Homo sapiens_hsa034202.74378055
11Ribosome_Homo sapiens_hsa030102.60533535
12Non-homologous end-joining_Homo sapiens_hsa034502.47679546
13One carbon pool by folate_Homo sapiens_hsa006702.20149078
14p53 signaling pathway_Homo sapiens_hsa041152.07109652
15RNA degradation_Homo sapiens_hsa030182.06995116
16RNA polymerase_Homo sapiens_hsa030202.06194733
17mRNA surveillance pathway_Homo sapiens_hsa030152.04983306
18Basal transcription factors_Homo sapiens_hsa030221.97076691
19Systemic lupus erythematosus_Homo sapiens_hsa053221.96428477
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95132716
21Pyrimidine metabolism_Homo sapiens_hsa002401.85786426
22Proteasome_Homo sapiens_hsa030501.70262650
23Oocyte meiosis_Homo sapiens_hsa041141.60149853
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.57654240
25Protein export_Homo sapiens_hsa030601.54797174
26Vitamin B6 metabolism_Homo sapiens_hsa007501.33767264
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31616409
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30193927
29Viral carcinogenesis_Homo sapiens_hsa052031.27226120
30Parkinsons disease_Homo sapiens_hsa050121.21084313
31Pyruvate metabolism_Homo sapiens_hsa006201.19597924
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19226636
33MicroRNAs in cancer_Homo sapiens_hsa052061.18911206
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18267694
35Herpes simplex infection_Homo sapiens_hsa051681.12215865
36Oxidative phosphorylation_Homo sapiens_hsa001901.09991259
37Huntingtons disease_Homo sapiens_hsa050161.09848858
38Epstein-Barr virus infection_Homo sapiens_hsa051691.06426710
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03734980
40HTLV-I infection_Homo sapiens_hsa051661.01923813
41Propanoate metabolism_Homo sapiens_hsa006400.99661072
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99641025
43Carbon metabolism_Homo sapiens_hsa012000.94830921
44Steroid biosynthesis_Homo sapiens_hsa001000.91599591
45Small cell lung cancer_Homo sapiens_hsa052220.90328075
46Purine metabolism_Homo sapiens_hsa002300.87477597
47Primary immunodeficiency_Homo sapiens_hsa053400.87107222
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86316556
49Alcoholism_Homo sapiens_hsa050340.85180843
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83644290
51Thyroid cancer_Homo sapiens_hsa052160.81666745
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80754853
53Colorectal cancer_Homo sapiens_hsa052100.76661186
54Fatty acid elongation_Homo sapiens_hsa000620.76340426
55Antigen processing and presentation_Homo sapiens_hsa046120.76092000
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72247300
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67620156
58Basal cell carcinoma_Homo sapiens_hsa052170.64144097
59Pentose phosphate pathway_Homo sapiens_hsa000300.63012216
60Chronic myeloid leukemia_Homo sapiens_hsa052200.59521207
61Apoptosis_Homo sapiens_hsa042100.59158113
62Alzheimers disease_Homo sapiens_hsa050100.58363324
63Pancreatic cancer_Homo sapiens_hsa052120.58331089
64Hippo signaling pathway_Homo sapiens_hsa043900.58150613
65TGF-beta signaling pathway_Homo sapiens_hsa043500.57930595
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56571712
67Notch signaling pathway_Homo sapiens_hsa043300.56263249
68Hepatitis B_Homo sapiens_hsa051610.55520775
69Selenocompound metabolism_Homo sapiens_hsa004500.52991760
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52390354
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52241371
72Non-small cell lung cancer_Homo sapiens_hsa052230.50379969
73mTOR signaling pathway_Homo sapiens_hsa041500.49959801
74Bladder cancer_Homo sapiens_hsa052190.49300369
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48789135
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48747632
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46991010
78Adherens junction_Homo sapiens_hsa045200.46661010
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46525948
80Pathways in cancer_Homo sapiens_hsa052000.46029651
81N-Glycan biosynthesis_Homo sapiens_hsa005100.46010785
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44026248
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42517484
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.40671593
85Lysine degradation_Homo sapiens_hsa003100.40538307
86FoxO signaling pathway_Homo sapiens_hsa040680.39286710
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.39245671
88Metabolic pathways_Homo sapiens_hsa011000.38728344
89Measles_Homo sapiens_hsa051620.37377059
90Hematopoietic cell lineage_Homo sapiens_hsa046400.36449751
91Biosynthesis of amino acids_Homo sapiens_hsa012300.34607624
92Influenza A_Homo sapiens_hsa051640.34317433
93Prostate cancer_Homo sapiens_hsa052150.33498661
94Legionellosis_Homo sapiens_hsa051340.33420380
95Hedgehog signaling pathway_Homo sapiens_hsa043400.33400966
96Sulfur relay system_Homo sapiens_hsa041220.32427951
97Viral myocarditis_Homo sapiens_hsa054160.32378742
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31930799
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.31895278
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31635064
101Shigellosis_Homo sapiens_hsa051310.30762202
102Fatty acid metabolism_Homo sapiens_hsa012120.29482153
103B cell receptor signaling pathway_Homo sapiens_hsa046620.28742070
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26604253
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.25535482
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.25442993
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.25361922
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.25044047
109Wnt signaling pathway_Homo sapiens_hsa043100.23955921
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23954461
111HIF-1 signaling pathway_Homo sapiens_hsa040660.23368982
112Fructose and mannose metabolism_Homo sapiens_hsa000510.23359685
113Arachidonic acid metabolism_Homo sapiens_hsa005900.23281459
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22878471
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21951022
116Proteoglycans in cancer_Homo sapiens_hsa052050.21473607
117Endometrial cancer_Homo sapiens_hsa052130.21030001
118Acute myeloid leukemia_Homo sapiens_hsa052210.20564394
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20086858
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18732366
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18173095
122T cell receptor signaling pathway_Homo sapiens_hsa046600.16623364
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15913854
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15715175
125Melanoma_Homo sapiens_hsa052180.15376183
126Glutathione metabolism_Homo sapiens_hsa004800.15278324
127Linoleic acid metabolism_Homo sapiens_hsa005910.14796052
128Folate biosynthesis_Homo sapiens_hsa007900.14649803
129Butanoate metabolism_Homo sapiens_hsa006500.13864286
130Arginine and proline metabolism_Homo sapiens_hsa003300.13311740
131Leishmaniasis_Homo sapiens_hsa051400.12907911
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11881140
133Fatty acid degradation_Homo sapiens_hsa000710.01592921

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