NUS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.16890391
2nuclear pore organization (GO:0006999)6.17408110
3regulation of NFAT protein import into nucleus (GO:0051532)5.46529356
4drug transmembrane transport (GO:0006855)5.07151340
5urate metabolic process (GO:0046415)5.04552353
6response to nerve growth factor (GO:1990089)5.02351660
7cellular response to nerve growth factor stimulus (GO:1990090)5.02351660
8pore complex assembly (GO:0046931)5.02293881
9regulation of RNA export from nucleus (GO:0046831)4.91502566
10lysine catabolic process (GO:0006554)4.77017883
11lysine metabolic process (GO:0006553)4.77017883
12regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.58570402
13mitotic chromosome condensation (GO:0007076)4.56569018
14negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.50709766
15regulation of mitotic spindle organization (GO:0060236)4.44201520
16aminoglycoside antibiotic metabolic process (GO:0030647)4.36678272
17regulation of nucleobase-containing compound transport (GO:0032239)4.32704793
18DNA unwinding involved in DNA replication (GO:0006268)4.32086605
19ribosome assembly (GO:0042255)4.10471913
20phosphate ion transport (GO:0006817)4.07365148
21drug catabolic process (GO:0042737)4.05310723
22drug transport (GO:0015893)4.03850890
23histone H3-K36 demethylation (GO:0070544)3.85844227
24positive regulation of SMAD protein import into nucleus (GO:0060391)3.81649783
25nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.78199479
26protein complex localization (GO:0031503)3.72718522
27cellular protein complex localization (GO:0034629)3.67835863
28exogenous drug catabolic process (GO:0042738)3.67524888
29protein localization to endosome (GO:0036010)3.66713472
30phosphate ion transmembrane transport (GO:0035435)3.63142609
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60518927
32mitotic sister chromatid cohesion (GO:0007064)3.58579285
33formation of translation preinitiation complex (GO:0001731)3.57681545
34cysteine metabolic process (GO:0006534)3.57111273
35heterochromatin organization (GO:0070828)3.52360588
36mitotic metaphase plate congression (GO:0007080)3.50919343
37sister chromatid cohesion (GO:0007062)3.50431252
38protein export from nucleus (GO:0006611)3.47307004
39regulation of spindle organization (GO:0090224)3.42980382
40Golgi transport vesicle coating (GO:0048200)3.40330659
41COPI coating of Golgi vesicle (GO:0048205)3.40330659
42proline biosynthetic process (GO:0006561)3.38812082
43protein localization to chromosome, centromeric region (GO:0071459)3.38793605
44sister chromatid segregation (GO:0000819)3.36515299
45cell adhesion mediated by integrin (GO:0033627)3.36416780
46membrane disassembly (GO:0030397)3.30815121
47nuclear envelope disassembly (GO:0051081)3.30815121
48mitotic nuclear envelope disassembly (GO:0007077)3.23304255
49folic acid-containing compound biosynthetic process (GO:0009396)3.21628305
50nucleoside diphosphate catabolic process (GO:0009134)3.19938828
51mitotic sister chromatid segregation (GO:0000070)3.14437450
52regulation of heat generation (GO:0031650)3.09877809
53establishment of nucleus localization (GO:0040023)3.08587000
54mRNA stabilization (GO:0048255)3.07880991
55RNA stabilization (GO:0043489)3.07880991
56organic cation transport (GO:0015695)3.06774326
57protein localization to kinetochore (GO:0034501)3.01081662
58oxidative phosphorylation (GO:0006119)3.00955860
59IMP biosynthetic process (GO:0006188)2.97052385
60IMP metabolic process (GO:0046040)2.96695028
61positive regulation of chromosome segregation (GO:0051984)2.96624324
62regulation of transcription from RNA polymerase III promoter (GO:0006359)2.95655425
63regulation of translational fidelity (GO:0006450)2.93521364
64glutamate metabolic process (GO:0006536)2.92900819
65regulation of actin nucleation (GO:0051125)2.92655511
66myelination in peripheral nervous system (GO:0022011)2.92411435
67peripheral nervous system axon ensheathment (GO:0032292)2.92411435
68COPII vesicle coating (GO:0048208)2.90892999
69glutamine metabolic process (GO:0006541)2.90157050
70quaternary ammonium group transport (GO:0015697)2.87128117
71regulation of sister chromatid cohesion (GO:0007063)2.86036437
72negative regulation of DNA repair (GO:0045738)2.84242010
73DNA replication initiation (GO:0006270)2.83551519
74dicarboxylic acid biosynthetic process (GO:0043650)2.83339971
75response to mercury ion (GO:0046689)2.82653608
76regulation of clathrin-mediated endocytosis (GO:2000369)2.81888482
77excretion (GO:0007588)2.80777219
78glyoxylate metabolic process (GO:0046487)2.80604434
79metaphase plate congression (GO:0051310)2.80213370
80aspartate family amino acid catabolic process (GO:0009068)2.80075584
81establishment of chromosome localization (GO:0051303)2.77324195
82apoptotic cell clearance (GO:0043277)2.76652594
83short-chain fatty acid metabolic process (GO:0046459)2.75499463
84establishment of integrated proviral latency (GO:0075713)2.75142194
85homocysteine metabolic process (GO:0050667)2.70356445
86tricarboxylic acid metabolic process (GO:0072350)2.70331946
87response to growth hormone (GO:0060416)2.68419803
88regulation of glucose import in response to insulin stimulus (GO:2001273)2.68153715
89nuclear envelope organization (GO:0006998)2.66278355
90dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66192220
91paraxial mesoderm development (GO:0048339)2.65192538
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63875850
93renal absorption (GO:0070293)2.63284725
94chromosome condensation (GO:0030261)2.62281224
95pre-miRNA processing (GO:0031054)2.61373878
96positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.61254141
97positive regulation of cell cycle G2/M phase transition (GO:1902751)2.61254141
98regulation of translational termination (GO:0006449)2.59218002
99regulation of SMAD protein import into nucleus (GO:0060390)2.57514807
100regulation of response to osmotic stress (GO:0047484)2.55622261
101aromatic amino acid family catabolic process (GO:0009074)2.54726832
102negative regulation of receptor activity (GO:2000272)2.53951060
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53875319
104cellular ketone body metabolic process (GO:0046950)2.53623759
105cerebral cortex radially oriented cell migration (GO:0021799)2.52705123
106focal adhesion assembly (GO:0048041)2.52029100
107cell-substrate adherens junction assembly (GO:0007045)2.52029100
108proline transport (GO:0015824)2.51445879
109regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.50146762
110cellular modified amino acid catabolic process (GO:0042219)2.49993336
111DNA topological change (GO:0006265)2.49934684
112DNA duplex unwinding (GO:0032508)2.49285916
113metanephric nephron epithelium development (GO:0072243)2.49228903
114growth hormone receptor signaling pathway (GO:0060396)2.48993753
115valine metabolic process (GO:0006573)2.48717459
116embryonic process involved in female pregnancy (GO:0060136)2.48572000
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48184797
118DNA strand elongation involved in DNA replication (GO:0006271)2.47754206
119indole-containing compound catabolic process (GO:0042436)2.47730003
120indolalkylamine catabolic process (GO:0046218)2.47730003
121tryptophan catabolic process (GO:0006569)2.47730003
122cellular response to vitamin D (GO:0071305)2.47133439
123regulation of chromosome segregation (GO:0051983)2.45778635
124DNA strand elongation (GO:0022616)2.44756634
125adenine nucleotide transport (GO:0051503)2.44436131
126transcytosis (GO:0045056)2.43931526
1274-hydroxyproline metabolic process (GO:0019471)2.43506194
128DNA-dependent DNA replication (GO:0006261)2.43413859
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43085613
130L-phenylalanine metabolic process (GO:0006558)2.43085613
131nuclear export (GO:0051168)2.42956220
132positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.42360221
133positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.42360221
134positive regulation of mitotic sister chromatid separation (GO:1901970)2.42360221
135metanephric nephron tubule development (GO:0072234)2.42126735
136metanephric tubule development (GO:0072170)2.42126735
137sodium ion export (GO:0071436)2.42016441
138peptidyl-threonine modification (GO:0018210)2.41972853
139modified amino acid transport (GO:0072337)2.41872432
140negative regulation of fibroblast apoptotic process (GO:2000270)2.41343595
141histone H2A monoubiquitination (GO:0035518)2.40743714
142cellular potassium ion homeostasis (GO:0030007)2.39963064
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.39506155
144regulation of DNA damage checkpoint (GO:2000001)2.38138776
145tryptophan metabolic process (GO:0006568)2.38109655
146pinocytosis (GO:0006907)2.38072889
147vitamin D metabolic process (GO:0042359)2.37787365
148purine ribonucleotide transport (GO:0015868)2.37640804
149erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.36747758
150L-phenylalanine catabolic process (GO:0006559)2.36747758
151layer formation in cerebral cortex (GO:0021819)2.36516481
152low-density lipoprotein particle clearance (GO:0034383)2.36042111
153regulation of early endosome to late endosome transport (GO:2000641)2.35507822
154kynurenine metabolic process (GO:0070189)2.33812956
155amino-acid betaine metabolic process (GO:0006577)2.33511372
1562-oxoglutarate metabolic process (GO:0006103)2.31337120
157regulation of cholesterol homeostasis (GO:2000188)2.31310492
158regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31217548
159cellular response to vitamin (GO:0071295)2.31109411
160positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.30987129
161clathrin coat assembly (GO:0048268)2.29549186
162hypotonic response (GO:0006971)2.27167498
163toxin transport (GO:1901998)2.26212466
164maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25645004
165cell migration involved in sprouting angiogenesis (GO:0002042)2.22739709
166stress fiber assembly (GO:0043149)2.22598109
167positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.21577079
168membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.20953446
169serine family amino acid catabolic process (GO:0009071)2.20690145
170amino-acid betaine transport (GO:0015838)2.20330975
171carnitine transport (GO:0015879)2.20330975
172cytoplasmic mRNA processing body assembly (GO:0033962)2.18518254
173urea metabolic process (GO:0019627)2.17695906
174urea cycle (GO:0000050)2.17695906
175positive regulation of glycolytic process (GO:0045821)2.15761432
176vitamin transport (GO:0051180)2.15289648
177ketone body metabolic process (GO:1902224)2.15286300
178regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.14965549
179insulin-like growth factor receptor signaling pathway (GO:0048009)2.14771678
180negative regulation of fatty acid transport (GO:2000192)2.14515461
181neurotransmitter biosynthetic process (GO:0042136)2.13614493
182fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.09997751
183response to magnesium ion (GO:0032026)2.09468038
184metanephric epithelium development (GO:0072207)2.09139299
185regulation of hippo signaling (GO:0035330)2.07976266
186alanine transport (GO:0032328)2.07958680
187peptide catabolic process (GO:0043171)2.07914191
188regulation of cholesterol storage (GO:0010885)2.07029218
189response to phenylpropanoid (GO:0080184)2.06953032
190bone resorption (GO:0045453)2.06945338
191cellular response to growth hormone stimulus (GO:0071378)2.06846394
192negative regulation of lipid transport (GO:0032369)2.06366835
193surfactant homeostasis (GO:0043129)2.05605630
194endocytic recycling (GO:0032456)2.04931932
195wound healing, spreading of epidermal cells (GO:0035313)2.04574910
196hippo signaling (GO:0035329)2.04173580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.76399585
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.86018634
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.87317598
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.23133880
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02674655
6AR_21909140_ChIP-Seq_LNCAP_Human2.94415352
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90305917
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.89410908
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.64137460
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61830113
11MYC_22102868_ChIP-Seq_BL_Human2.52021713
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.48795578
13* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.45403958
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45197291
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43914434
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29599642
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.28063978
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27538861
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.27345263
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.25975244
21CLOCK_20551151_ChIP-Seq_293T_Human2.25354831
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12395755
23ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06692485
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03093864
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99926996
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98421834
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97473409
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95013358
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93305322
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93305322
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93305322
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92678463
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.91971221
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.90396425
35ZNF263_19887448_ChIP-Seq_K562_Human1.88706010
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86830830
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81700232
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76707375
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71977082
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.70530302
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.70174302
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70067878
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69655869
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69040383
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69040383
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66295217
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.64551686
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64478213
49RXR_22108803_ChIP-Seq_LS180_Human1.63359536
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63057363
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59547915
52* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.56912824
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56396532
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55588857
55CJUN_26792858_Chip-Seq_BT549_Human1.53303262
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51578780
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.49526384
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.45589334
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44152212
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.42465462
61SOX2_20726797_ChIP-Seq_SW620_Human1.40841045
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40603378
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40585363
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40331560
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39637009
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39278558
67TFEB_21752829_ChIP-Seq_HELA_Human1.38307867
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38025230
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36729056
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.34648169
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33885069
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.32995558
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32755716
74CHD1_26751641_Chip-Seq_LNCaP_Human1.32715753
75* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32378434
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.31082254
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28365728
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26621748
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26439854
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26059410
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.25894282
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25626542
83TP53_18474530_ChIP-ChIP_U2OS_Human1.25111501
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23828971
85* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23611254
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23518060
87TP53_16413492_ChIP-PET_HCT116_Human1.23132314
88AHR_22903824_ChIP-Seq_MCF-7_Human1.22995461
89* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22258281
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21174081
91DCP1A_22483619_ChIP-Seq_HELA_Human1.19825621
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19506272
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19334168
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18861008
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.18788376
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17498793
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16956609
98TP63_23658742_ChIP-Seq_EP156T_Human1.15429571
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.11389750
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.10525077
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09998718
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.09903548
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.09763953
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09739279
105GATA4_25053715_ChIP-Seq_YYC3_Human1.08648430
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08281761
107VDR_24787735_ChIP-Seq_THP-1_Human1.07205880
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06908516
109* TTF2_22483619_ChIP-Seq_HELA_Human1.05965829
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05942095
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.05337045
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03554101
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03094140
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03065604
115XRN2_22483619_ChIP-Seq_HELA_Human1.02945535
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02869941
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02853675
118CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02524269
119KDM2B_26808549_Chip-Seq_K562_Human1.02281298
120* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02272528
121GATA6_25053715_ChIP-Seq_YYC3_Human1.02114967
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01529510
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01529510
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00961357
125E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00411455
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00181524
127MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00141114
128UBF1/2_26484160_Chip-Seq_HMECs_Human1.00128296
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00037879
130ATF3_27146783_Chip-Seq_COLON_Human0.99800423
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99683644
132TCF7_22412390_ChIP-Seq_EML_Mouse0.99529354
133* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99389665
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99184450
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99181571
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98753761
137* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98237939
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.97692510
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97650075
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97426322
141* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97336707
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97152530
143BRD4_25478319_ChIP-Seq_HGPS_Human0.96779119
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96581196
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95809202
146STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94986019
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94038416
148PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93963530
149FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93641002
150ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93524323
151SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93523669
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93073960
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92931052
154KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92123548
155* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92058973
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91572293
157TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90931835
158AR_21572438_ChIP-Seq_LNCaP_Human0.90793576
159RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90758640
160JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90384030
161TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89991959
162IRF8_27001747_Chip-Seq_BMDM_Mouse0.89984939
163DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89913436
164HNF4A_19822575_ChIP-Seq_HepG2_Human0.89387390
165NCOR1_26117541_ChIP-Seq_K562_Human0.88452920
166EGR1_19374776_ChIP-ChIP_THP-1_Human0.88296299
167* CDX2_22108803_ChIP-Seq_LS180_Human0.87578973
168FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86957705
169TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84787650
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83635273
171NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83055301
172NANOG_21062744_ChIP-ChIP_HESCs_Human0.80531791
173THAP11_20581084_ChIP-Seq_MESCs_Mouse0.80356880
174SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79531698
175ELK1_19687146_ChIP-ChIP_HELA_Human0.79025644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.34289705
2MP0003705_abnormal_hypodermis_morpholog3.75655620
3MP0002139_abnormal_hepatobiliary_system3.65892584
4MP0010234_abnormal_vibrissa_follicle3.58386940
5MP0004043_abnormal_pH_regulation3.40548314
6MP0003693_abnormal_embryo_hatching3.05735256
7MP0003300_gastrointestinal_ulcer3.02549369
8MP0004957_abnormal_blastocyst_morpholog2.98513373
9MP0008057_abnormal_DNA_replication2.92166152
10MP0003195_calcinosis2.83266661
11MP0003252_abnormal_bile_duct2.67581324
12MP0005332_abnormal_amino_acid2.64605777
13MP0002138_abnormal_hepatobiliary_system2.64577423
14MP0003941_abnormal_skin_development2.64329769
15MP0004019_abnormal_vitamin_homeostasis2.62557989
16MP0003111_abnormal_nucleus_morphology2.61224304
17MP0001730_embryonic_growth_arrest2.46109936
18MP0005085_abnormal_gallbladder_physiolo2.38167668
19MP0005451_abnormal_body_composition2.29436735
20MP0009780_abnormal_chondrocyte_physiolo2.11761419
21MP0001765_abnormal_ion_homeostasis2.11557954
22MP0010352_gastrointestinal_tract_polyps2.11399911
23MP0008260_abnormal_autophagy2.10790604
24MP0009643_abnormal_urine_homeostasis2.10117223
25MP0010094_abnormal_chromosome_stability2.08730104
26MP0003077_abnormal_cell_cycle2.00677256
27MP0001756_abnormal_urination2.00034891
28MP0002796_impaired_skin_barrier1.96719292
29MP0008932_abnormal_embryonic_tissue1.95733347
30MP0005058_abnormal_lysosome_morphology1.91471155
31MP0005167_abnormal_blood-brain_barrier1.90916964
32MP0003303_peritoneal_inflammation1.88709996
33MP0010307_abnormal_tumor_latency1.81117828
34MP0001958_emphysema1.75530721
35MP0000350_abnormal_cell_proliferation1.74626754
36MP0003890_abnormal_embryonic-extraembry1.68739738
37MP0003283_abnormal_digestive_organ1.68146110
38MP0005380_embryogenesis_phenotype1.67242372
39MP0001672_abnormal_embryogenesis/_devel1.67242372
40MP0002136_abnormal_kidney_physiology1.67229462
41MP0002896_abnormal_bone_mineralization1.65703169
42MP0002086_abnormal_extraembryonic_tissu1.64958991
43MP0005365_abnormal_bile_salt1.63746663
44MP0008438_abnormal_cutaneous_collagen1.63162184
45MP0008961_abnormal_basal_metabolism1.63023014
46MP0001697_abnormal_embryo_size1.62021307
47MP0008875_abnormal_xenobiotic_pharmacok1.61871621
48MP0004272_abnormal_basement_membrane1.58398866
49MP0002088_abnormal_embryonic_growth/wei1.55390639
50MP0002877_abnormal_melanocyte_morpholog1.54544937
51MP0003984_embryonic_growth_retardation1.53804130
52MP0004782_abnormal_surfactant_physiolog1.53742247
53MP0000762_abnormal_tongue_morphology1.52357404
54MP0002080_prenatal_lethality1.51506931
55MP0009672_abnormal_birth_weight1.51463223
56MP0004808_abnormal_hematopoietic_stem1.51327258
57MP0002697_abnormal_eye_size1.50526986
58MP0002085_abnormal_embryonic_tissue1.45896999
59MP0005076_abnormal_cell_differentiation1.45606846
60MP0008007_abnormal_cellular_replicative1.42892740
61MP0002084_abnormal_developmental_patter1.42761816
62MP0004859_abnormal_synaptic_plasticity1.42086024
63MP0002249_abnormal_larynx_morphology1.40007179
64MP0003191_abnormal_cellular_cholesterol1.39419239
65MP0002009_preneoplasia1.37298366
66MP0002168_other_aberrant_phenotype1.37287425
67MP0005623_abnormal_meninges_morphology1.35755796
68MP0003566_abnormal_cell_adhesion1.34672254
69MP0003075_altered_response_to1.33787750
70MP0005501_abnormal_skin_physiology1.30673515
71MP0000604_amyloidosis1.30022284
72MP0001216_abnormal_epidermal_layer1.28733353
73MP0005636_abnormal_mineral_homeostasis1.28244233
74MP0001849_ear_inflammation1.28087606
75MP0002396_abnormal_hematopoietic_system1.27355189
76MP0005248_abnormal_Harderian_gland1.25990280
77MP0001881_abnormal_mammary_gland1.25813997
78MP0004264_abnormal_extraembryonic_tissu1.25228186
79MP0004858_abnormal_nervous_system1.24168354
80MP0005166_decreased_susceptibility_to1.21666088
81MP0002998_abnormal_bone_remodeling1.21334113
82MP0003091_abnormal_cell_migration1.19494196
83MP0002233_abnormal_nose_morphology1.18761560
84MP0000428_abnormal_craniofacial_morphol1.18578756
85MP0000432_abnormal_head_morphology1.17873842
86MP0003935_abnormal_craniofacial_develop1.17498033
87MP0004233_abnormal_muscle_weight1.16759415
88MP0003567_abnormal_fetal_cardiomyocyte1.16028259
89MP0003045_fibrosis1.15711441
90MP0009697_abnormal_copulation1.13912485
91MP0003172_abnormal_lysosome_physiology1.12733130
92MP0005084_abnormal_gallbladder_morpholo1.12313830
93MP0001666_abnormal_nutrient_absorption1.11887912
94MP0006054_spinal_hemorrhage1.11762463
95MP0002928_abnormal_bile_duct1.11171094
96MP0005621_abnormal_cell_physiology1.10876571
97MP0003950_abnormal_plasma_membrane1.09084429
98MP0010329_abnormal_lipoprotein_level1.08545496
99MP0009053_abnormal_anal_canal1.08380413
100MP0003329_amyloid_beta_deposits1.07887387
101MP0005584_abnormal_enzyme/coenzyme_acti1.06375184
102MP0004197_abnormal_fetal_growth/weight/1.06168909
103MP0002060_abnormal_skin_morphology1.05147829
104MP0004185_abnormal_adipocyte_glucose1.04680560
105MP0005535_abnormal_body_temperature1.02139900
106MP0000313_abnormal_cell_death1.02076315
107MP0010368_abnormal_lymphatic_system1.01175008
108MP0000490_abnormal_crypts_of0.97903063
109MP0005319_abnormal_enzyme/_coenzyme0.97118035
110MP0000678_abnormal_parathyroid_gland0.96123983
111MP0005666_abnormal_adipose_tissue0.95298844
112MP0002295_abnormal_pulmonary_circulatio0.95169420
113MP0000537_abnormal_urethra_morphology0.93901040
114MP0000538_abnormal_urinary_bladder0.93798652
115MP0002118_abnormal_lipid_homeostasis0.92659693
116MP0000609_abnormal_liver_physiology0.91396200
117MP0004130_abnormal_muscle_cell0.90722865
118MP0001177_atelectasis0.89953986
119MP0009250_abnormal_appendicular_skeleto0.89255958
120MP0000627_abnormal_mammary_gland0.88660648
121MP0008004_abnormal_stomach_pH0.87390165
122MP0005384_cellular_phenotype0.87016253
123MP0002254_reproductive_system_inflammat0.86858568
124MP0009764_decreased_sensitivity_to0.86719643
125MP0000613_abnormal_salivary_gland0.86439405
126MP0005023_abnormal_wound_healing0.84546846
127MP0010630_abnormal_cardiac_muscle0.84542541
128MP0003942_abnormal_urinary_system0.84367702
129MP0003755_abnormal_palate_morphology0.83922414
130MP0002909_abnormal_adrenal_gland0.83168784
131MP0003943_abnormal_hepatobiliary_system0.82456031
132MP0003221_abnormal_cardiomyocyte_apopto0.82103764
133MP0001286_abnormal_eye_development0.81671494
134MP0009703_decreased_birth_body0.81024891
135MP0003937_abnormal_limbs/digits/tail_de0.79819899
136MP0005375_adipose_tissue_phenotype0.79546715
137MP0002925_abnormal_cardiovascular_devel0.79319640
138MP0004270_analgesia0.79078315
139MP0003878_abnormal_ear_physiology0.78648790
140MP0005377_hearing/vestibular/ear_phenot0.78648790
141MP0000049_abnormal_middle_ear0.78476974
142MP0000003_abnormal_adipose_tissue0.78312499
143MP0003385_abnormal_body_wall0.77992062
144MP0005164_abnormal_response_to0.77959510
145MP0009931_abnormal_skin_appearance0.77504580
146MP0002092_abnormal_eye_morphology0.76921975
147MP0004484_altered_response_of0.76409402
148MP0000013_abnormal_adipose_tissue0.75393456
149MP0005257_abnormal_intraocular_pressure0.75346484
150MP0001293_anophthalmia0.73265543
151MP0005083_abnormal_biliary_tract0.72886309
152MP0001533_abnormal_skeleton_physiology0.72553895
153MP0000579_abnormal_nail_morphology0.72189942
154MP0003115_abnormal_respiratory_system0.72051120
155MP0008058_abnormal_DNA_repair0.71657358
156MP0004885_abnormal_endolymph0.70921718
157MP0000230_abnormal_systemic_arterial0.70878083
158MP0002135_abnormal_kidney_morphology0.69702121
159MP0001879_abnormal_lymphatic_vessel0.69360634
160MP0001299_abnormal_eye_distance/0.68941608
161MP0003448_altered_tumor_morphology0.68745130
162MP0000858_altered_metastatic_potential0.68679890
163MP0002115_abnormal_skeleton_extremities0.67878938
164MP0003795_abnormal_bone_structure0.67450443
165MP0005275_abnormal_skin_tensile0.67325740
166MP0005395_other_phenotype0.66876442
167MP0000377_abnormal_hair_follicle0.65909947
168MP0002089_abnormal_postnatal_growth/wei0.65068669
169MP0002822_catalepsy0.64672946
170MP0003690_abnormal_glial_cell0.62486163
171MP0001915_intracranial_hemorrhage0.62003010
172MP0003868_abnormal_feces_composition0.61797881
173MP0000598_abnormal_liver_morphology0.60756728
174MP0009384_cardiac_valve_regurgitation0.60196371
175MP0002078_abnormal_glucose_homeostasis0.58790569
176MP0003453_abnormal_keratinocyte_physiol0.58364775
177MP0010386_abnormal_urinary_bladder0.56937694

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)4.74697080
2Metabolic alkalosis (HP:0200114)4.59364960
3Abnormality of chloride homeostasis (HP:0011422)4.54957913
4Gout (HP:0001997)4.51115394
5Hyperactive renin-angiotensin system (HP:0000841)4.50433786
6Increased circulating renin level (HP:0000848)4.49962991
7Hypokalemic alkalosis (HP:0001949)4.38082805
8Abnormality of the intrinsic pathway (HP:0010989)4.23555689
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.02501468
10Long nose (HP:0003189)3.49333988
11Polyuria (HP:0000103)3.35530951
12Abnormal urine output (HP:0012590)3.31610011
13Abnormality of renal excretion (HP:0011036)3.30758402
14Hypomagnesemia (HP:0002917)3.29502206
15Increased purine levels (HP:0004368)3.29102251
16Hyperuricemia (HP:0002149)3.29102251
17Abnormality of purine metabolism (HP:0004352)3.27922893
18Abnormality of proline metabolism (HP:0010907)3.24331661
19Hydroxyprolinuria (HP:0003080)3.24331661
20Overlapping toe (HP:0001845)3.22478408
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08769333
22Proximal tubulopathy (HP:0000114)3.08298803
23Chromsome breakage (HP:0040012)2.98980276
24Ankyloglossia (HP:0010296)2.91002863
25Tetany (HP:0001281)2.89782852
26Oligodontia (HP:0000677)2.86165974
27Abnormality of renin-angiotensin system (HP:0000847)2.85479324
28Conical tooth (HP:0000698)2.85403750
29Alkalosis (HP:0001948)2.82658359
30Abnormality of magnesium homeostasis (HP:0004921)2.75706275
31Achilles tendon contracture (HP:0001771)2.70797710
32Capillary hemangiomas (HP:0005306)2.67737552
33Hyperaldosteronism (HP:0000859)2.66863327
34Abnormal drinking behavior (HP:0030082)2.65196767
35Polydipsia (HP:0001959)2.65196767
36Hyperglycinuria (HP:0003108)2.60125564
37Bilateral sensorineural hearing impairment (HP:0008619)2.59176063
38Acute lymphatic leukemia (HP:0006721)2.57686275
39Syringomyelia (HP:0003396)2.53479223
40Spinal cord lesions (HP:0100561)2.53479223
41Deep philtrum (HP:0002002)2.53096659
42Thin bony cortex (HP:0002753)2.52623421
43Abnormality of the Achilles tendon (HP:0005109)2.51695973
44Ketoacidosis (HP:0001993)2.49647619
45Renal salt wasting (HP:0000127)2.47448750
46Pseudobulbar signs (HP:0002200)2.46967562
47Diastasis recti (HP:0001540)2.45538987
48Lymphangioma (HP:0100764)2.44569954
49Heterotopia (HP:0002282)2.43764098
50Neoplasm of the oral cavity (HP:0100649)2.43565675
51Hypercalciuria (HP:0002150)2.35586490
52Hypokalemia (HP:0002900)2.34484625
53Abnormality of nucleobase metabolism (HP:0010932)2.31777227
54Cardiovascular calcification (HP:0011915)2.30907103
55Abnormality of the salivary glands (HP:0010286)2.30682505
56Acute myeloid leukemia (HP:0004808)2.30613856
57Urinary glycosaminoglycan excretion (HP:0003541)2.29705727
58Mucopolysacchariduria (HP:0008155)2.29705727
59Absent eyebrow (HP:0002223)2.29438470
60Vascular calcification (HP:0004934)2.26060105
61Uterine leiomyosarcoma (HP:0002891)2.25710852
62Leiomyosarcoma (HP:0100243)2.25710852
63Sensorimotor neuropathy (HP:0007141)2.23339442
64Asymmetry of the thorax (HP:0001555)2.22725551
65Protrusio acetabuli (HP:0003179)2.21794217
66Axonal loss (HP:0003447)2.20373696
67Upper motor neuron abnormality (HP:0002127)2.19351691
68Myocardial infarction (HP:0001658)2.19144246
69Abnormality of potassium homeostasis (HP:0011042)2.19104135
70Subacute progressive viral hepatitis (HP:0006572)2.19014159
71Cervical subluxation (HP:0003308)2.18494092
72Type I transferrin isoform profile (HP:0003642)2.17442302
73Premature rupture of membranes (HP:0001788)2.17316099
74Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.16713185
75Abnormality of glycine metabolism (HP:0010895)2.14943442
76Abnormality of serine family amino acid metabolism (HP:0010894)2.14943442
77Gastrointestinal carcinoma (HP:0002672)2.14208950
78Malignant gastrointestinal tract tumors (HP:0006749)2.14208950
79Abnormality of oral frenula (HP:0000190)2.10993355
80Nephrolithiasis (HP:0000787)2.07915566
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07218566
82Abnormality of polysaccharide metabolism (HP:0011012)2.07218566
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07218566
84Dysostosis multiplex (HP:0000943)2.07131676
85Hypophosphatemia (HP:0002148)2.06830345
86Deep venous thrombosis (HP:0002625)2.04224462
87Nephroblastoma (Wilms tumor) (HP:0002667)2.03782983
88Metaphyseal cupping (HP:0003021)2.03661631
89Renal tubular acidosis (HP:0001947)2.01774407
90Xanthomatosis (HP:0000991)2.01636817
91Anal stenosis (HP:0002025)2.00407168
92Transitional cell carcinoma of the bladder (HP:0006740)2.00099976
93Cerebral aneurysm (HP:0004944)1.99990931
94Papilledema (HP:0001085)1.99855331
95Unilateral renal agenesis (HP:0000122)1.99321345
96Ketosis (HP:0001946)1.98775051
97Chondrocalcinosis (HP:0000934)1.98473441
98Arnold-Chiari malformation (HP:0002308)1.98224329
99Embryonal renal neoplasm (HP:0011794)1.97048773
100Esophageal varix (HP:0002040)1.96752090
101Wide nose (HP:0000445)1.96657736
102Focal segmental glomerulosclerosis (HP:0000097)1.96164707
103Increased nuchal translucency (HP:0010880)1.95681310
104Glomerulosclerosis (HP:0000096)1.93680341
105Rickets (HP:0002748)1.90316641
106Protuberant abdomen (HP:0001538)1.89512232
107Selective tooth agenesis (HP:0001592)1.88069107
108Abnormality of the lumbar spine (HP:0100712)1.86766799
109Mitral valve prolapse (HP:0001634)1.86482778
110Hand muscle atrophy (HP:0009130)1.86345487
111Hyperacusis (HP:0010780)1.86078946
112Deviation of the thumb (HP:0009603)1.86075641
113Disproportionate tall stature (HP:0001519)1.84420401
114Hematochezia (HP:0002573)1.83744164
115Upper limb amyotrophy (HP:0009129)1.83649763
116Distal upper limb amyotrophy (HP:0007149)1.83649763
117Insomnia (HP:0100785)1.83480429
118Skull defect (HP:0001362)1.83429152
119Abnormal foot bone ossification (HP:0010675)1.80132582
120Thin skin (HP:0000963)1.79692259
121Spastic diplegia (HP:0001264)1.79680267
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79620846
123Tubulointerstitial fibrosis (HP:0005576)1.79613129
124Potter facies (HP:0002009)1.79124538
125Facial shape deformation (HP:0011334)1.79124538
126Lower limb amyotrophy (HP:0007210)1.78902114
127Hepatocellular carcinoma (HP:0001402)1.78760403
128Abnormality of Sharpey fibers (HP:0100685)1.77805627
129Bladder neoplasm (HP:0009725)1.76080023
130Bladder carcinoma (HP:0002862)1.76080023
131Arterial tortuosity (HP:0005116)1.75406430
132Global brain atrophy (HP:0002283)1.74947963
133Vascular tortuosity (HP:0004948)1.73775520
134Broad palm (HP:0001169)1.73752274
135Progressive muscle weakness (HP:0003323)1.73312529
136Smooth philtrum (HP:0000319)1.72254687
137Vacuolated lymphocytes (HP:0001922)1.70753171
138Flat acetabular roof (HP:0003180)1.70506967
139Hyperphosphaturia (HP:0003109)1.70301341
140Preaxial foot polydactyly (HP:0001841)1.69936850
141Delayed epiphyseal ossification (HP:0002663)1.69689684
142Relative macrocephaly (HP:0004482)1.69421502
143Adrenal overactivity (HP:0002717)1.69418733
144Abnormal lung lobation (HP:0002101)1.69389577
145Glycosuria (HP:0003076)1.68200476
146Abnormality of urine glucose concentration (HP:0011016)1.68200476
147Aortic aneurysm (HP:0004942)1.68152559
148Macroorchidism (HP:0000053)1.67385532
149Disinhibition (HP:0000734)1.67354513
150Nonimmune hydrops fetalis (HP:0001790)1.66734983
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.66626523
152Back pain (HP:0003418)1.66379220
153Abnormality of glycolipid metabolism (HP:0010969)1.66042575
154Abnormality of liposaccharide metabolism (HP:0010968)1.66042575
155Abnormality of glycosphingolipid metabolism (HP:0004343)1.66042575
156Abnormality of the common coagulation pathway (HP:0010990)1.65842678
157Hyperammonemia (HP:0001987)1.65698218
158Genu recurvatum (HP:0002816)1.65353502
159Lower limb asymmetry (HP:0100559)1.65215239
160Hypoglycemic coma (HP:0001325)1.65190413
161Mitral stenosis (HP:0001718)1.64791872
162Rectal prolapse (HP:0002035)1.64787773
163Peritonitis (HP:0002586)1.64421577
164Proximal placement of thumb (HP:0009623)1.61403281
165Hepatoblastoma (HP:0002884)1.60659429
166Midface retrusion (HP:0011800)1.59759146
167Multiple enchondromatosis (HP:0005701)1.59469046
168Renal cell carcinoma (HP:0005584)1.58829890
169Multiple lipomas (HP:0001012)1.57990608
170Sandal gap (HP:0001852)1.57379592
171Breech presentation (HP:0001623)1.56546086
172Cubitus valgus (HP:0002967)1.55687805
173Uterine neoplasm (HP:0010784)1.54159458
174Transposition of the great arteries (HP:0001669)1.53733362
175Abnormal connection of the cardiac segments (HP:0011545)1.53733362
176Abnormal ventriculo-arterial connection (HP:0011563)1.53733362
177Short middle phalanx of the 5th finger (HP:0004220)1.51628395
178Advanced eruption of teeth (HP:0006288)1.51489411
179Abnormal protein glycosylation (HP:0012346)1.50085207
180Abnormal glycosylation (HP:0012345)1.50085207
181Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.50085207
182Abnormal protein N-linked glycosylation (HP:0012347)1.50085207
183Facial cleft (HP:0002006)1.49361990
184Insidious onset (HP:0003587)1.49139798
185Termporal pattern (HP:0011008)1.49139798
186Cortical dysplasia (HP:0002539)1.48518609
187Thoracic kyphosis (HP:0002942)1.48157737
188Abnormality of chromosome stability (HP:0003220)1.47858556
189Missing ribs (HP:0000921)1.47450570
190Abnormality of the thoracic spine (HP:0100711)1.46465217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.95716249
2CDK123.41716005
3WNK33.19712885
4FRK2.94120863
5LATS12.87046881
6CDC42BPA2.83203591
7TRIB32.44624513
8OXSR12.39841887
9PKN22.34416345
10LATS22.29409341
11TTK2.23489819
12BCR2.21102565
13PRPF4B2.09389537
14EIF2AK32.05972857
15EEF2K2.05537327
16SMG12.03585890
17MAP3K91.98789867
18MAP3K21.98264548
19IRAK31.97132460
20EIF2AK11.88269931
21KSR21.80733758
22RIPK11.79331040
23ICK1.78488793
24CDC71.77086801
25MAP3K101.73877525
26BRD41.70861898
27ERN11.67055717
28PDGFRA1.65496472
29CDK31.63794087
30STK381.56875528
31STK38L1.52005955
32SCYL21.50987047
33MST1R1.46919814
34DDR21.46322888
35TAOK11.44709010
36STK241.40923905
37PBK1.40476254
38NME21.40171294
39STK31.34097133
40RIPK41.33349675
41FGFR41.33012503
42TSSK61.31756880
43NTRK31.31131249
44TNIK1.30975203
45PTK61.30627451
46TAF11.26280353
47WNK11.24823186
48NEK11.23938986
49NEK91.23568378
50MAP3K131.23232252
51BUB11.23036692
52MKNK11.22343694
53SIK11.21263323
54PRKD31.16498010
55MAP3K81.16232355
56NTRK11.15824044
57SIK21.15490606
58STK391.15086466
59RPS6KB21.14943932
60RPS6KA41.13160577
61ALK1.12935406
62SRPK11.12530392
63EPHA41.11016076
64SGK31.10727189
65RET1.10350585
66ERBB41.10089725
67EPHA21.08326954
68CAMKK11.07352480
69CLK11.06800514
70BMX1.06277833
71ABL21.06215002
72PTK21.06088422
73TAOK31.04358494
74FER1.02957843
75MINK10.99613284
76MOS0.97857597
77CDK70.96278726
78NEK20.95933596
79PAK30.95209429
80PRKCH0.93560852
81FGFR30.93347182
82MAP2K40.92918442
83EPHB20.91214716
84PASK0.88845632
85LRRK20.88200922
86MAP3K30.86313348
87MAP3K140.86073494
88MKNK20.86032300
89PDPK10.83304017
90CHEK10.82068893
91CDK60.81356452
92PLK40.81094435
93MELK0.79465679
94PDK20.79333015
95MTOR0.78631518
96PAK60.78308985
97PDGFRB0.76788283
98TGFBR20.76443398
99SGK4940.75828328
100SGK2230.75828328
101MAP3K10.75091715
102SIK30.74636803
103PDK10.74110759
104TAOK20.73361987
105BRSK20.72774998
106MAP3K40.71806585
107PLK20.71101212
108SGK20.70766690
109CSNK1G20.70187168
110CHEK20.70042008
111GSK3A0.69228154
112DMPK0.69103757
113PIK3CA0.68361570
114KSR10.67962729
115TYRO30.67646811
116WEE10.67141334
117MAP3K50.64725873
118ATM0.64692002
119JAK20.64419573
120MARK30.64367393
121SGK10.63761938
122BRAF0.63278617
123CDK40.63027483
124PTK2B0.62251456
125PLK30.61201489
126PLK10.60880985
127CAMK1G0.60577406
128MAP2K10.59983318
129STK100.58856115
130EPHB10.58629182
131TTN0.58518944
132PDK40.56693302
133PDK30.56693302
134YES10.56307998
135MARK10.54061626
136MET0.53308131
137CAMK1D0.52780182
138ARAF0.51986191
139FGFR10.51603307
140PNCK0.51047769
141MATK0.50590228
142FLT30.49489195
143PRKDC0.48766190
144PAK20.48059839
145EIF2AK20.46829517
146EGFR0.46615793
147PAK40.44511999
148JAK10.44118570
149STK110.43915994
150MAP3K60.41784924
151CDK20.41012288
152PRKAA10.41005420
153DAPK20.40060512
154INSR0.39793924
155CSNK1E0.39385097
156CDK10.37925139
157STK160.36466438

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.98670654
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.84588064
3DNA replication_Homo sapiens_hsa030302.51956607
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42629250
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17472295
6Thyroid cancer_Homo sapiens_hsa052162.15831542
7Cell cycle_Homo sapiens_hsa041102.12869177
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09677996
9RNA transport_Homo sapiens_hsa030132.08818741
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06952763
11Arginine biosynthesis_Homo sapiens_hsa002202.04020859
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04003819
13Butanoate metabolism_Homo sapiens_hsa006502.03797074
14Non-homologous end-joining_Homo sapiens_hsa034501.98879471
15Vitamin B6 metabolism_Homo sapiens_hsa007501.98701217
16mRNA surveillance pathway_Homo sapiens_hsa030151.89545266
17N-Glycan biosynthesis_Homo sapiens_hsa005101.89121143
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78978891
19Bile secretion_Homo sapiens_hsa049761.75089502
20Spliceosome_Homo sapiens_hsa030401.61233282
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59120761
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59058973
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48402115
24Mismatch repair_Homo sapiens_hsa034301.44752336
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44234550
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.42800019
27Other glycan degradation_Homo sapiens_hsa005111.41655256
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40232268
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38205106
30Tryptophan metabolism_Homo sapiens_hsa003801.37513331
31Propanoate metabolism_Homo sapiens_hsa006401.29402170
32Colorectal cancer_Homo sapiens_hsa052101.29100068
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28754394
34B cell receptor signaling pathway_Homo sapiens_hsa046621.28680568
35One carbon pool by folate_Homo sapiens_hsa006701.27007208
36Mineral absorption_Homo sapiens_hsa049781.25937161
37MicroRNAs in cancer_Homo sapiens_hsa052061.19927073
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17844968
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15092620
40Nucleotide excision repair_Homo sapiens_hsa034201.14811071
41Sphingolipid metabolism_Homo sapiens_hsa006001.10968645
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.10909489
43Prolactin signaling pathway_Homo sapiens_hsa049171.08023306
44Protein digestion and absorption_Homo sapiens_hsa049741.08020238
45PPAR signaling pathway_Homo sapiens_hsa033201.07285522
46Fatty acid degradation_Homo sapiens_hsa000711.07239767
47Acute myeloid leukemia_Homo sapiens_hsa052211.07037000
48Collecting duct acid secretion_Homo sapiens_hsa049661.06542871
49Sulfur metabolism_Homo sapiens_hsa009201.05763800
50Hepatitis B_Homo sapiens_hsa051611.01186978
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97953059
52Thyroid hormone synthesis_Homo sapiens_hsa049180.96546447
53Lysosome_Homo sapiens_hsa041420.95578184
54RNA degradation_Homo sapiens_hsa030180.94894977
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94278019
56Lysine degradation_Homo sapiens_hsa003100.93494684
57Vitamin digestion and absorption_Homo sapiens_hsa049770.93442633
58Dorso-ventral axis formation_Homo sapiens_hsa043200.92572166
59p53 signaling pathway_Homo sapiens_hsa041150.91147689
60Starch and sucrose metabolism_Homo sapiens_hsa005000.90754183
61Prion diseases_Homo sapiens_hsa050200.90690697
62Peroxisome_Homo sapiens_hsa041460.90104052
63Amoebiasis_Homo sapiens_hsa051460.89998601
64beta-Alanine metabolism_Homo sapiens_hsa004100.89707548
65Pentose phosphate pathway_Homo sapiens_hsa000300.87716848
66HTLV-I infection_Homo sapiens_hsa051660.86608786
67Glioma_Homo sapiens_hsa052140.86467908
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.86304341
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.85597466
70Gastric acid secretion_Homo sapiens_hsa049710.84478838
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.84193087
72Hepatitis C_Homo sapiens_hsa051600.83698340
73Pyruvate metabolism_Homo sapiens_hsa006200.82980428
74Fatty acid metabolism_Homo sapiens_hsa012120.82145111
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.82075455
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81178257
77Focal adhesion_Homo sapiens_hsa045100.80710569
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80210562
79Adherens junction_Homo sapiens_hsa045200.80095905
80TGF-beta signaling pathway_Homo sapiens_hsa043500.79710767
81mTOR signaling pathway_Homo sapiens_hsa041500.77811721
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77418056
83ECM-receptor interaction_Homo sapiens_hsa045120.76301335
84Synaptic vesicle cycle_Homo sapiens_hsa047210.76099644
85Insulin resistance_Homo sapiens_hsa049310.75883358
86Herpes simplex infection_Homo sapiens_hsa051680.74392906
87Shigellosis_Homo sapiens_hsa051310.73819786
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.73214098
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72828030
90Insulin signaling pathway_Homo sapiens_hsa049100.72588693
91Apoptosis_Homo sapiens_hsa042100.71966218
92Bladder cancer_Homo sapiens_hsa052190.71845971
93Steroid biosynthesis_Homo sapiens_hsa001000.71805725
94Epstein-Barr virus infection_Homo sapiens_hsa051690.71145947
95Proteoglycans in cancer_Homo sapiens_hsa052050.70134659
96Type II diabetes mellitus_Homo sapiens_hsa049300.69639585
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69368121
98Oocyte meiosis_Homo sapiens_hsa041140.69337216
99Viral carcinogenesis_Homo sapiens_hsa052030.69306458
100Biosynthesis of amino acids_Homo sapiens_hsa012300.68952412
101Long-term potentiation_Homo sapiens_hsa047200.68177430
102Measles_Homo sapiens_hsa051620.68048122
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67507798
104Cocaine addiction_Homo sapiens_hsa050300.67260281
105Pancreatic cancer_Homo sapiens_hsa052120.66392465
106Complement and coagulation cascades_Homo sapiens_hsa046100.65036831
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.64719399
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64528393
109Influenza A_Homo sapiens_hsa051640.64517205
110Renin-angiotensin system_Homo sapiens_hsa046140.63591856
111Osteoclast differentiation_Homo sapiens_hsa043800.60913990
112Renal cell carcinoma_Homo sapiens_hsa052110.60339996
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60278649
114Glycerolipid metabolism_Homo sapiens_hsa005610.60235800
115HIF-1 signaling pathway_Homo sapiens_hsa040660.60002838
116Staphylococcus aureus infection_Homo sapiens_hsa051500.58908319
117Choline metabolism in cancer_Homo sapiens_hsa052310.58487423
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58271207
119Chronic myeloid leukemia_Homo sapiens_hsa052200.58250594
120Hippo signaling pathway_Homo sapiens_hsa043900.57823912
121Base excision repair_Homo sapiens_hsa034100.57469424
122Renin secretion_Homo sapiens_hsa049240.57426999
123Tuberculosis_Homo sapiens_hsa051520.56974196
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56542133
125Pathways in cancer_Homo sapiens_hsa052000.56405064
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55199144
127Carbon metabolism_Homo sapiens_hsa012000.54613898
128Basal transcription factors_Homo sapiens_hsa030220.53652084
129Small cell lung cancer_Homo sapiens_hsa052220.52700031
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51966440
131Tight junction_Homo sapiens_hsa045300.51840080
132Estrogen signaling pathway_Homo sapiens_hsa049150.51294414
133Arginine and proline metabolism_Homo sapiens_hsa003300.51156607
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50988483
135Endometrial cancer_Homo sapiens_hsa052130.49538634
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49488721
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.47390039
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.47104475
139Salivary secretion_Homo sapiens_hsa049700.47085020
140Selenocompound metabolism_Homo sapiens_hsa004500.46644510
141Wnt signaling pathway_Homo sapiens_hsa043100.46522272
142Non-small cell lung cancer_Homo sapiens_hsa052230.45822497
143Dopaminergic synapse_Homo sapiens_hsa047280.45350196
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45218919
145TNF signaling pathway_Homo sapiens_hsa046680.44981656
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44648632
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44539264
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44312046
149GnRH signaling pathway_Homo sapiens_hsa049120.43929854
150Insulin secretion_Homo sapiens_hsa049110.43649805
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.43642810
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43602885
153Pyrimidine metabolism_Homo sapiens_hsa002400.42899653
154Phagosome_Homo sapiens_hsa041450.42724721
155Rap1 signaling pathway_Homo sapiens_hsa040150.42328381
156Fatty acid biosynthesis_Homo sapiens_hsa000610.42051190
157Melanoma_Homo sapiens_hsa052180.41920077
158ErbB signaling pathway_Homo sapiens_hsa040120.41751108
159Amphetamine addiction_Homo sapiens_hsa050310.41185693
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40988766
161Toxoplasmosis_Homo sapiens_hsa051450.40839242
162Prostate cancer_Homo sapiens_hsa052150.40259228
163Phenylalanine metabolism_Homo sapiens_hsa003600.40093102
164VEGF signaling pathway_Homo sapiens_hsa043700.40021082
165Vibrio cholerae infection_Homo sapiens_hsa051100.39835731
166Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39416284
167Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38954049

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