NUPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)7.54337101
2intestinal cholesterol absorption (GO:0030299)6.11035933
3protein retention in ER lumen (GO:0006621)5.79910700
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.58295887
5digestion (GO:0007586)5.39355855
6ethanol oxidation (GO:0006069)5.13072138
7primary alcohol catabolic process (GO:0034310)4.67484004
8sperm motility (GO:0030317)4.53967997
9cellular ketone body metabolic process (GO:0046950)4.29883276
10antibacterial humoral response (GO:0019731)4.09594786
11acrosome reaction (GO:0007340)4.08984490
12fusion of sperm to egg plasma membrane (GO:0007342)4.06178245
13antimicrobial humoral response (GO:0019730)3.92990145
14multicellular organismal water homeostasis (GO:0050891)3.85301563
15ethanol metabolic process (GO:0006067)3.81805929
16surfactant homeostasis (GO:0043129)3.81443403
17regulation of phospholipase A2 activity (GO:0032429)3.80736549
18ketone body metabolic process (GO:1902224)3.80507317
19endothelial cell chemotaxis (GO:0035767)3.76038777
20response to misfolded protein (GO:0051788)3.70840529
21ceramide catabolic process (GO:0046514)3.70747656
22cilium or flagellum-dependent cell motility (GO:0001539)3.70340399
23glycolipid catabolic process (GO:0019377)3.70091025
24atrioventricular valve morphogenesis (GO:0003181)3.68712608
25response to pheromone (GO:0019236)3.68681425
26peptidyl-proline hydroxylation (GO:0019511)3.68081453
27membrane lipid catabolic process (GO:0046466)3.65752993
28indole-containing compound catabolic process (GO:0042436)3.65676472
29indolalkylamine catabolic process (GO:0046218)3.65676472
30tryptophan catabolic process (GO:0006569)3.65676472
31COPI coating of Golgi vesicle (GO:0048205)3.65457851
32Golgi transport vesicle coating (GO:0048200)3.65457851
33multicellular organism reproduction (GO:0032504)3.58129393
34transcytosis (GO:0045056)3.56114715
35cobalamin metabolic process (GO:0009235)3.53387589
36extracellular regulation of signal transduction (GO:1900115)3.52421127
37extracellular negative regulation of signal transduction (GO:1900116)3.52421127
38regulation of sarcomere organization (GO:0060297)3.50411530
39positive regulation of heat generation (GO:0031652)3.48674662
40chemical homeostasis within a tissue (GO:0048875)3.46413397
41keratan sulfate catabolic process (GO:0042340)3.44160536
42NAD biosynthetic process (GO:0009435)3.41171284
43intestinal epithelial cell development (GO:0060576)3.37311687
44behavioral response to nicotine (GO:0035095)3.34228503
45positive regulation of p38MAPK cascade (GO:1900745)3.33667109
46kynurenine metabolic process (GO:0070189)3.30213349
47positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.29373577
48desmosome organization (GO:0002934)3.24641949
49calcium ion-dependent exocytosis (GO:0017156)3.22042264
50O-glycan processing (GO:0016266)3.21302264
51negative regulation of translation, ncRNA-mediated (GO:0040033)3.21000125
52regulation of translation, ncRNA-mediated (GO:0045974)3.21000125
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21000125
54multicellular organismal movement (GO:0050879)3.20038143
55musculoskeletal movement (GO:0050881)3.20038143
56valine metabolic process (GO:0006573)3.20032986
57signal peptide processing (GO:0006465)3.15561519
58regulation of fever generation (GO:0031620)3.15252221
59water homeostasis (GO:0030104)3.14188721
60positive regulation of osteoblast proliferation (GO:0033690)3.12200107
61bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11837904
62gamma-aminobutyric acid transport (GO:0015812)3.09511971
63regulation of heat generation (GO:0031650)3.08443223
64axonemal dynein complex assembly (GO:0070286)3.05877716
65antigen processing and presentation via MHC class Ib (GO:0002475)3.04825350
66protein hydroxylation (GO:0018126)3.03393883
67plasma membrane fusion (GO:0045026)2.99345558
68protein polyglutamylation (GO:0018095)2.98686225
69negative regulation of epidermal cell differentiation (GO:0045605)2.98423994
70interleukin-1-mediated signaling pathway (GO:0070498)2.96140168
71indolalkylamine metabolic process (GO:0006586)2.96041157
72tryptophan metabolic process (GO:0006568)2.92829196
73detection of molecule of bacterial origin (GO:0032490)2.92052528
74ER overload response (GO:0006983)2.91723167
75positive regulation of CREB transcription factor activity (GO:0032793)2.89466149
76cellular response to pH (GO:0071467)2.86021469
77reproduction (GO:0000003)2.84479275
78renal absorption (GO:0070293)2.82646431
79regulation of keratinocyte differentiation (GO:0045616)2.81625421
80detection of light stimulus involved in visual perception (GO:0050908)2.80875460
81detection of light stimulus involved in sensory perception (GO:0050962)2.80875460
82regulation of water loss via skin (GO:0033561)2.80223042
83sperm capacitation (GO:0048240)2.79881488
84peptide catabolic process (GO:0043171)2.79842477
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79556745
86alanine transport (GO:0032328)2.78551547
87negative regulation of systemic arterial blood pressure (GO:0003085)2.76181711
88apoptotic cell clearance (GO:0043277)2.76127311
89regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.75283804
90endoplasmic reticulum unfolded protein response (GO:0030968)2.75274091
91membrane depolarization during action potential (GO:0086010)2.73676662
92regulation of keratinocyte proliferation (GO:0010837)2.73132333
93cilium movement (GO:0003341)2.73119641
94multicellular organismal catabolic process (GO:0044243)2.72783799
95positive regulation of protein kinase C signaling (GO:0090037)2.71846517
96primary amino compound metabolic process (GO:1901160)2.71567207
97cellular response to unfolded protein (GO:0034620)2.70472688
98regulation of chemokine secretion (GO:0090196)2.70176257
99sphingolipid catabolic process (GO:0030149)2.69919796
100xenobiotic catabolic process (GO:0042178)2.69738054
101nicotinamide nucleotide biosynthetic process (GO:0019359)2.69710215
102pyridine nucleotide biosynthetic process (GO:0019363)2.69710215
103positive regulation of fatty acid oxidation (GO:0046321)2.69272534
104establishment of protein localization to Golgi (GO:0072600)2.68701568
105activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.68002580
106drug catabolic process (GO:0042737)2.66886770
107amine catabolic process (GO:0009310)2.66673745
108cellular biogenic amine catabolic process (GO:0042402)2.66673745
109mitochondrial calcium ion transport (GO:0006851)2.64314676
110epithelial cilium movement (GO:0003351)2.63359444
111epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62783633
112response to endoplasmic reticulum stress (GO:0034976)2.61933785
113establishment of skin barrier (GO:0061436)2.61317159
114regulation of cilium movement (GO:0003352)2.59526767
115negative regulation of chondrocyte differentiation (GO:0032331)2.58392257
116protein K48-linked deubiquitination (GO:0071108)2.56912282
117kidney mesenchyme development (GO:0072074)2.56059009
118prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.55669212
119multicellular organismal metabolic process (GO:0044236)2.54373103
120indole-containing compound metabolic process (GO:0042430)2.52748543
121spermatid development (GO:0007286)2.52641503
122motile cilium assembly (GO:0044458)2.51871249
123regulation of hippo signaling (GO:0035330)2.51728265
124glomerular visceral epithelial cell development (GO:0072015)2.51451079
125positive regulation of Rab GTPase activity (GO:0032851)2.51395216
126regulation of Rab GTPase activity (GO:0032313)2.51395216
127polyketide metabolic process (GO:0030638)2.50383109
128doxorubicin metabolic process (GO:0044598)2.50383109
129daunorubicin metabolic process (GO:0044597)2.50383109
130nucleotide-sugar biosynthetic process (GO:0009226)2.50367501
131ER-nucleus signaling pathway (GO:0006984)2.49640973
132wound healing, spreading of epidermal cells (GO:0035313)2.49220564
133UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48415539
134negative regulation of protein localization to cell surface (GO:2000009)2.48194147
135macroautophagy (GO:0016236)2.47881360
136coenzyme catabolic process (GO:0009109)2.47743144
137positive regulation of fatty acid beta-oxidation (GO:0032000)2.47550386
138response to acidic pH (GO:0010447)2.46935791
139positive regulation of nuclease activity (GO:0032075)2.46820275
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46780222
141regulation of interleukin-8 secretion (GO:2000482)2.46557959
142G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45844035
143collagen fibril organization (GO:0030199)2.44860533
144positive regulation of action potential (GO:0045760)2.43812018
145organic cation transport (GO:0015695)2.43796419
146cholesterol catabolic process (GO:0006707)2.43603985
147sterol catabolic process (GO:0016127)2.43603985
148retinoic acid metabolic process (GO:0042573)2.43164067
149lipoxygenase pathway (GO:0019372)2.43122050
150aromatic amino acid family catabolic process (GO:0009074)2.42597773
151cellular response to topologically incorrect protein (GO:0035967)2.42419624
152metanephric mesenchyme development (GO:0072075)2.42250464
153flavonoid metabolic process (GO:0009812)2.42084414
154negative regulation of sodium ion transport (GO:0010766)2.40787995
155cAMP catabolic process (GO:0006198)2.40591448
156extracellular matrix disassembly (GO:0022617)2.40499677
157neutrophil activation involved in immune response (GO:0002283)2.40124585
158dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.39683971
159regulation of transcription involved in cell fate commitment (GO:0060850)2.39304855
160intestinal absorption (GO:0050892)2.39089396
161reflex (GO:0060004)2.39079178
162wound healing, spreading of cells (GO:0044319)2.38648140
163positive regulation of histone deacetylation (GO:0031065)2.37997172
164negative regulation of Rho protein signal transduction (GO:0035024)2.37983329
165endocardial cushion development (GO:0003197)2.37300565
166endosome to pigment granule transport (GO:0043485)2.37041944
167endosome to melanosome transport (GO:0035646)2.37041944
168phenylpropanoid metabolic process (GO:0009698)2.36399391
169phosphatidylethanolamine biosynthetic process (GO:0006646)2.36376441
170collagen catabolic process (GO:0030574)2.34668543
171serotonin metabolic process (GO:0042428)2.34407291
172skeletal muscle adaptation (GO:0043501)2.33616406
173regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.31803143
174peristalsis (GO:0030432)2.30976461
175positive regulation of steroid biosynthetic process (GO:0010893)2.30852423
176oxidative demethylation (GO:0070989)2.30468620
177cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.29495691
178ganglion development (GO:0061548)2.29401190
179skin morphogenesis (GO:0043589)2.28016779
180urinary tract smooth muscle contraction (GO:0014848)2.27852790
181striated muscle atrophy (GO:0014891)2.27123129
182metanephric nephron tubule development (GO:0072234)2.26901319
183metanephric tubule development (GO:0072170)2.26901319
184negative regulation of epidermis development (GO:0045683)2.26772172
185collagen metabolic process (GO:0032963)2.26603303
186cell proliferation involved in kidney development (GO:0072111)2.25910805
187regulation of microtubule-based movement (GO:0060632)2.25816301
188response to follicle-stimulating hormone (GO:0032354)2.25333307
189regulation of nuclease activity (GO:0032069)2.24518421
190regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.22510909
191cyclic nucleotide catabolic process (GO:0009214)2.21692148
192appendage development (GO:0048736)2.21113052
193limb development (GO:0060173)2.21113052
194phosphatidylethanolamine metabolic process (GO:0046337)2.21022782
195respiratory tube development (GO:0030323)2.20975980
196phenol-containing compound catabolic process (GO:0019336)2.19944243
197axoneme assembly (GO:0035082)2.18873952
198exogenous drug catabolic process (GO:0042738)2.18465575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.16258879
2EZH2_22144423_ChIP-Seq_EOC_Human5.33667188
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.72621447
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.60633937
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.55370694
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.54721085
7* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.39183950
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21115287
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.00705652
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.80157295
11DROSHA_22980978_ChIP-Seq_HELA_Human2.66390601
12* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.63495227
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.61944329
14SOX2_20726797_ChIP-Seq_SW620_Human2.46304633
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24195284
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10230702
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04175079
18VDR_22108803_ChIP-Seq_LS180_Human1.99328546
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98733150
20* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.98691544
21CJUN_26792858_Chip-Seq_BT549_Human1.98624259
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.91614431
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.91614431
24GATA4_25053715_ChIP-Seq_YYC3_Human1.88784384
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86477483
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.86215750
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85765814
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.85266056
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82318900
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82318900
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.79732733
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78516459
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78258886
34GBX2_23144817_ChIP-Seq_PC3_Human1.78240029
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77088768
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.75233096
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74808539
38* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.69299737
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.64636052
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.61888239
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61376201
42TP53_18474530_ChIP-ChIP_U2OS_Human1.58928801
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56410148
44CLOCK_20551151_ChIP-Seq_293T_Human1.55932237
45AR_21572438_ChIP-Seq_LNCaP_Human1.53929945
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53762054
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53713804
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53439364
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.53256159
50ZNF274_21170338_ChIP-Seq_K562_Hela1.53021508
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52057583
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50950785
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50950785
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50950785
55GATA1_22025678_ChIP-Seq_K562_Human1.45106106
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44227784
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.42602671
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42185217
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41036408
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40518940
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40220248
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40220248
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.39614177
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37505823
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37505823
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36891271
67GATA3_24758297_ChIP-Seq_MCF-7_Human1.36051803
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35884737
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34655489
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34580562
71RXR_22108803_ChIP-Seq_LS180_Human1.33975277
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32825861
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32311100
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32092668
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.29657513
76* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28867083
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.28312639
78* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27999386
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27482414
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26335404
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24127323
82* GATA6_25053715_ChIP-Seq_YYC3_Human1.22697739
83REST_21632747_ChIP-Seq_MESCs_Mouse1.22442893
84AR_25329375_ChIP-Seq_VCAP_Human1.19581331
85* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19193607
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18658155
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18444431
88STAT3_23295773_ChIP-Seq_U87_Human1.16934545
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.16357977
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15190765
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.15184777
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14829117
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14701431
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14296889
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14234698
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14178425
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13702329
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13668527
99SMAD4_21799915_ChIP-Seq_A2780_Human1.13258882
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12971015
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12700127
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11979080
103CTCF_27219007_Chip-Seq_Bcells_Human1.11473811
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10845597
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10464342
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.09687091
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08482975
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08208673
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08085997
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07274971
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06512342
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.06032157
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05850112
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05818251
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05703555
116KLF5_25053715_ChIP-Seq_YYC3_Human1.05653579
117BCAT_22108803_ChIP-Seq_LS180_Human1.05519860
118IRF8_27001747_Chip-Seq_BMDM_Mouse1.03781973
119* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03658132
120ER_23166858_ChIP-Seq_MCF-7_Human1.03362162
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03113145
122ATF3_27146783_Chip-Seq_COLON_Human1.02069836
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00979925
124TCF4_23295773_ChIP-Seq_U87_Human1.00643108
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99898694
126IRF8_21731497_ChIP-ChIP_J774_Mouse0.99199113
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98520638
128LXR_22158963_ChIP-Seq_LIVER_Mouse0.98453022
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.98351568
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.97613799
131* TP63_23658742_ChIP-Seq_EP156T_Human0.97502061
132OCT4_20526341_ChIP-Seq_ESCs_Human0.97183151
133ERA_21632823_ChIP-Seq_H3396_Human0.97001655
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96063026
135VDR_24787735_ChIP-Seq_THP-1_Human0.95635066
136RACK7_27058665_Chip-Seq_MCF-7_Human0.95216846
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94754517
138GATA3_21878914_ChIP-Seq_MCF-7_Human0.94280381
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.93516775
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92660835
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92634433
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92566997
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92277937
144ERG_21242973_ChIP-ChIP_JURKAT_Human0.92088666
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.92046557
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.91818139
147CBP_20019798_ChIP-Seq_JUKART_Human0.91057433
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91057433
149BRD4_25478319_ChIP-Seq_HGPS_Human0.90925435
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90435046
151AHR_22903824_ChIP-Seq_MCF-7_Human0.90203464
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89749801
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88832060
154* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88488220
155P300_19829295_ChIP-Seq_ESCs_Human0.88417316
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88324812
157TP53_16413492_ChIP-PET_HCT116_Human0.88239927
158RUNX2_22187159_ChIP-Seq_PCA_Human0.88194216
159TP63_22573176_ChIP-Seq_HFKS_Human0.88125383
160OCT1_27270436_Chip-Seq_PROSTATE_Human0.87309215
161TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87138223
162RUNX_20019798_ChIP-Seq_JUKART_Human0.87060944
163* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86018795
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.85993460
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85658336
166MYC_19829295_ChIP-Seq_ESCs_Human0.85326198
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85213880
168KDM2B_26808549_Chip-Seq_REH_Human0.84654965
169TBX20_22328084_ChIP-Seq_HEART_Mouse0.83166982
170TBX20_22080862_ChIP-Seq_HEART_Mouse0.83166982
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82023220
172RXR_22158963_ChIP-Seq_LIVER_Mouse0.81448837
173STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80694405
174ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80634502
175WT1_19549856_ChIP-ChIP_CCG9911_Human0.80540293
176* FOXA1_25552417_ChIP-Seq_VCAP_Human0.79289483
177EGR1_19032775_ChIP-ChIP_M12_Human0.78914409
178ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78876680
179SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78378138
180IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78043554
181BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73657791
182TP53_20018659_ChIP-ChIP_R1E_Mouse0.73458097
183ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.73085864
184NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73007716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.40869210
2MP0005670_abnormal_white_adipose4.08762839
3MP0005410_abnormal_fertilization3.84554565
4MP0001666_abnormal_nutrient_absorption3.76195984
5MP0008438_abnormal_cutaneous_collagen3.57399985
6MP0003878_abnormal_ear_physiology3.49763932
7MP0005377_hearing/vestibular/ear_phenot3.49763932
8MP0005220_abnormal_exocrine_pancreas3.37786103
9MP0005275_abnormal_skin_tensile2.95058030
10MP0001501_abnormal_sleep_pattern2.72753539
11MP0003941_abnormal_skin_development2.62649250
12MP0005503_abnormal_tendon_morphology2.55010899
13MP0008004_abnormal_stomach_pH2.25117829
14MP0003879_abnormal_hair_cell2.23869494
15MP0003646_muscle_fatigue2.22496734
16MP0004264_abnormal_extraembryonic_tissu2.18926488
17MP0002277_abnormal_respiratory_mucosa2.15409414
18MP0006054_spinal_hemorrhage2.14051258
19MP0002735_abnormal_chemical_nociception2.14005163
20MP0001348_abnormal_lacrimal_gland2.05908562
21MP0005365_abnormal_bile_salt2.04155322
22MP0002876_abnormal_thyroid_physiology1.93985812
23MP0001485_abnormal_pinna_reflex1.91644328
24MP0005084_abnormal_gallbladder_morpholo1.88485741
25MP0003868_abnormal_feces_composition1.88128915
26MP0003279_aneurysm1.78675008
27MP0004782_abnormal_surfactant_physiolog1.77426887
28MP0003283_abnormal_digestive_organ1.76393711
29MP0003566_abnormal_cell_adhesion1.73248406
30MP0009745_abnormal_behavioral_response1.73210955
31MP0005551_abnormal_eye_electrophysiolog1.73058975
32MP0002060_abnormal_skin_morphology1.72506255
33MP0002132_abnormal_respiratory_system1.69561230
34MP0003011_delayed_dark_adaptation1.67088540
35MP0001542_abnormal_bone_strength1.64936474
36MP0002295_abnormal_pulmonary_circulatio1.64153528
37MP0001958_emphysema1.63826372
38MP0002733_abnormal_thermal_nociception1.63267847
39MP0010368_abnormal_lymphatic_system1.63033440
40MP0003705_abnormal_hypodermis_morpholog1.60420564
41MP0001440_abnormal_grooming_behavior1.54164112
42MP0008875_abnormal_xenobiotic_pharmacok1.53503125
43MP0004130_abnormal_muscle_cell1.52773438
44MP0003950_abnormal_plasma_membrane1.52627438
45MP0010234_abnormal_vibrissa_follicle1.52534395
46MP0004019_abnormal_vitamin_homeostasis1.46807222
47MP0005508_abnormal_skeleton_morphology1.45382604
48MP0009046_muscle_twitch1.45077797
49MP0001970_abnormal_pain_threshold1.44771922
50MP0001664_abnormal_digestion1.43241256
51MP0003186_abnormal_redox_activity1.41294456
52MP0004272_abnormal_basement_membrane1.41149639
53MP0003828_pulmonary_edema1.40159766
54MP0002877_abnormal_melanocyte_morpholog1.39243770
55MP0000678_abnormal_parathyroid_gland1.39234701
56MP0002796_impaired_skin_barrier1.36750853
57MP0003698_abnormal_male_reproductive1.36109120
58MP0004885_abnormal_endolymph1.35889813
59MP0005165_increased_susceptibility_to1.34513656
60MP0002098_abnormal_vibrissa_morphology1.34230527
61MP0006276_abnormal_autonomic_nervous1.31728142
62MP0001879_abnormal_lymphatic_vessel1.31292579
63MP0000230_abnormal_systemic_arterial1.30538465
64MP0001968_abnormal_touch/_nociception1.28903408
65MP0002896_abnormal_bone_mineralization1.28584717
66MP0002693_abnormal_pancreas_physiology1.26834688
67MP0002557_abnormal_social/conspecific_i1.26673697
68MP0002822_catalepsy1.25915369
69MP0002933_joint_inflammation1.25742117
70MP0002148_abnormal_hypersensitivity_rea1.24830588
71MP0005390_skeleton_phenotype1.23024330
72MP0005595_abnormal_vascular_smooth1.22799799
73MP0000371_diluted_coat_color1.21776914
74MP0009780_abnormal_chondrocyte_physiolo1.21673691
75MP0004142_abnormal_muscle_tone1.21269451
76MP0000343_altered_response_to1.20949416
77MP0005023_abnormal_wound_healing1.20901417
78MP0003724_increased_susceptibility_to1.18867765
79MP0005167_abnormal_blood-brain_barrier1.18766673
80MP0002998_abnormal_bone_remodeling1.18667703
81MP0010329_abnormal_lipoprotein_level1.18172485
82MP0000762_abnormal_tongue_morphology1.17524260
83MP0001765_abnormal_ion_homeostasis1.16768472
84MP0003300_gastrointestinal_ulcer1.16616426
85MP0001486_abnormal_startle_reflex1.16615012
86MP0002572_abnormal_emotion/affect_behav1.15788096
87MP0000026_abnormal_inner_ear1.15689980
88MP0003045_fibrosis1.15570889
89MP0001905_abnormal_dopamine_level1.14777763
90MP0004145_abnormal_muscle_electrophysio1.14527391
91MP0004043_abnormal_pH_regulation1.14291457
92MP0001533_abnormal_skeleton_physiology1.13760254
93MP0002272_abnormal_nervous_system1.12394507
94MP0003172_abnormal_lysosome_physiology1.11939761
95MP0008961_abnormal_basal_metabolism1.11329975
96MP0000163_abnormal_cartilage_morphology1.11095932
97MP0005408_hypopigmentation1.10444594
98MP0010386_abnormal_urinary_bladder1.09869466
99MP0005085_abnormal_gallbladder_physiolo1.09848950
100MP0003959_abnormal_lean_body1.09842046
101MP0009250_abnormal_appendicular_skeleto1.09500893
102MP0003453_abnormal_keratinocyte_physiol1.08979109
103MP0003795_abnormal_bone_structure1.08747153
104MP0002734_abnormal_mechanical_nocicepti1.08374547
105MP0002067_abnormal_sensory_capabilities1.08356119
106MP0000538_abnormal_urinary_bladder1.08346288
107MP0002108_abnormal_muscle_morphology1.08167838
108MP0002064_seizures1.07463028
109MP0000613_abnormal_salivary_gland1.07395712
110MP0003436_decreased_susceptibility_to1.06485712
111MP0004742_abnormal_vestibular_system1.02713334
112MP0004134_abnormal_chest_morphology1.02323691
113MP0008872_abnormal_physiological_respon1.01745506
114MP0009053_abnormal_anal_canal1.01164396
115MP0000569_abnormal_digit_pigmentation0.99647495
116MP0005448_abnormal_energy_balance0.99485830
117MP0009278_abnormal_bone_marrow0.99408405
118MP0002653_abnormal_ependyma_morphology0.98683525
119MP0002138_abnormal_hepatobiliary_system0.97613652
120MP0000470_abnormal_stomach_morphology0.96156104
121MP0001756_abnormal_urination0.95462734
122MP0000858_altered_metastatic_potential0.94536582
123MP0001963_abnormal_hearing_physiology0.94457843
124MP0010030_abnormal_orbit_morphology0.93171880
125MP0001944_abnormal_pancreas_morphology0.92017213
126MP0009115_abnormal_fat_cell0.91999563
127MP0002254_reproductive_system_inflammat0.91780198
128MP0005647_abnormal_sex_gland0.90555198
129MP0002113_abnormal_skeleton_development0.89178564
130MP0005164_abnormal_response_to0.89147137
131MP0001270_distended_abdomen0.88752212
132MP0001346_abnormal_lacrimal_gland0.87413682
133MP0000681_abnormal_thyroid_gland0.87323453
134MP0002638_abnormal_pupillary_reflex0.86768512
135MP0009764_decreased_sensitivity_to0.86259830
136MP0005646_abnormal_pituitary_gland0.84654712
137MP0009643_abnormal_urine_homeostasis0.84312970
138MP0005248_abnormal_Harderian_gland0.84218232
139MP0004133_heterotaxia0.84114189
140MP0003195_calcinosis0.82800764
141MP0003632_abnormal_nervous_system0.82265559
142MP0005332_abnormal_amino_acid0.82256153
143MP0004185_abnormal_adipocyte_glucose0.80547889
144MP0001216_abnormal_epidermal_layer0.79552161
145MP0002419_abnormal_innate_immunity0.79303133
146MP0002234_abnormal_pharynx_morphology0.79236191
147MP0005058_abnormal_lysosome_morphology0.79123969
148MP0002115_abnormal_skeleton_extremities0.78789172
149MP0004085_abnormal_heartbeat0.78308172
150MP0000767_abnormal_smooth_muscle0.78029957
151MP0009384_cardiac_valve_regurgitation0.77878067
152MP0002282_abnormal_trachea_morphology0.76427331
153MP0005645_abnormal_hypothalamus_physiol0.76417638
154MP0000534_abnormal_ureter_morphology0.76310816
155MP0002249_abnormal_larynx_morphology0.75795988
156MP0002168_other_aberrant_phenotype0.75495848
157MP0003635_abnormal_synaptic_transmissio0.75438307
158MP0003075_altered_response_to0.75409225
159MP0002133_abnormal_respiratory_system0.75368179
160MP0005388_respiratory_system_phenotype0.75368179
161MP0002089_abnormal_postnatal_growth/wei0.75109982
162MP0003448_altered_tumor_morphology0.74245153
163MP0005423_abnormal_somatic_nervous0.73070539
164MP0005253_abnormal_eye_physiology0.72570066
165MP0002118_abnormal_lipid_homeostasis0.72560120
166MP0002229_neurodegeneration0.72548889
167MP0005257_abnormal_intraocular_pressure0.72321749
168MP0002405_respiratory_system_inflammati0.72067755
169MP0009840_abnormal_foam_cell0.71940926
170MP0005367_renal/urinary_system_phenotyp0.71865790
171MP0000516_abnormal_urinary_system0.71865790
172MP0003633_abnormal_nervous_system0.71534356
173MP0003631_nervous_system_phenotype0.71353466
174MP0003136_yellow_coat_color0.70720304

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)6.28327397
2Abnormality of cochlea (HP:0000375)5.28421715
3Progressive cerebellar ataxia (HP:0002073)4.59051393
4Renal salt wasting (HP:0000127)4.45674280
5Abnormality of chloride homeostasis (HP:0011422)4.35838633
6Hyperactive renin-angiotensin system (HP:0000841)4.29137743
7Epiphyseal dysplasia (HP:0002656)4.12848541
8Hypokalemic alkalosis (HP:0001949)3.98098590
9Tubulointerstitial fibrosis (HP:0005576)3.84347357
10Decreased circulating renin level (HP:0003351)3.71678024
11Hyperventilation (HP:0002883)3.59702802
12Hyperaldosteronism (HP:0000859)3.59051361
13Hyperkalemia (HP:0002153)3.41048176
14Gaze-evoked nystagmus (HP:0000640)3.38548855
15Absent/shortened dynein arms (HP:0200106)3.30974352
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.30974352
17Morphological abnormality of the inner ear (HP:0011390)3.28718380
18Diplopia (HP:0000651)3.25175788
19Abnormality of binocular vision (HP:0011514)3.25175788
20Metabolic alkalosis (HP:0200114)3.21690779
21Nephronophthisis (HP:0000090)3.21483669
22Abnormal tarsal ossification (HP:0008369)3.19450025
23Right ventricular cardiomyopathy (HP:0011663)3.19152340
24Bell-shaped thorax (HP:0001591)3.11875197
25Chronic hepatic failure (HP:0100626)3.11698258
26Distal lower limb muscle weakness (HP:0009053)3.11246960
27Congenital stationary night blindness (HP:0007642)3.10802341
28Attenuation of retinal blood vessels (HP:0007843)3.07309764
29Clumsiness (HP:0002312)2.95590368
30Decreased subcutaneous fat (HP:0001002)2.93214956
31Small epiphyses (HP:0010585)2.88613872
32Severe visual impairment (HP:0001141)2.87414160
33Cupped ribs (HP:0000887)2.87216276
34Abnormality of the renal medulla (HP:0100957)2.86474684
35Neonatal short-limb short stature (HP:0008921)2.82700135
36Hypoplastic ischia (HP:0003175)2.81989680
37Abnormal respiratory epithelium morphology (HP:0012253)2.81481230
38Abnormal respiratory motile cilium morphology (HP:0005938)2.81481230
39Abnormal ciliary motility (HP:0012262)2.81308106
40Cervical subluxation (HP:0003308)2.80867676
41Pancreatic cysts (HP:0001737)2.78066667
42Steatorrhea (HP:0002570)2.73144245
43Atrophic scars (HP:0001075)2.71656217
44Flat acetabular roof (HP:0003180)2.70678166
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.70456437
46Beaking of vertebral bodies (HP:0004568)2.68713696
47Vitreoretinal degeneration (HP:0000655)2.68188441
48Onycholysis (HP:0001806)2.67226368
49Exocrine pancreatic insufficiency (HP:0001738)2.65072922
50Abnormal drinking behavior (HP:0030082)2.60501474
51Polydipsia (HP:0001959)2.60501474
52Premature rupture of membranes (HP:0001788)2.59079618
53Abnormality of the renal cortex (HP:0011035)2.58881236
54Cystic liver disease (HP:0006706)2.54048510
55Decreased central vision (HP:0007663)2.52532523
56Abnormality of the ischium (HP:0003174)2.50919002
57Pancreatic fibrosis (HP:0100732)2.50558799
58Molar tooth sign on MRI (HP:0002419)2.50066643
59Abnormality of midbrain morphology (HP:0002418)2.50066643
60Irregular epiphyses (HP:0010582)2.49177278
61Tubulointerstitial abnormality (HP:0001969)2.49021958
62Bony spicule pigmentary retinopathy (HP:0007737)2.47600530
63Tubulointerstitial nephritis (HP:0001970)2.46507952
64Abnormal foot bone ossification (HP:0010675)2.46457057
65Facial shape deformation (HP:0011334)2.43904470
66Potter facies (HP:0002009)2.43904470
67Abnormal respiratory motile cilium physiology (HP:0012261)2.40964909
68Follicular hyperkeratosis (HP:0007502)2.40956870
69True hermaphroditism (HP:0010459)2.40602371
70Abnormality of renal excretion (HP:0011036)2.39512086
71Alopecia of scalp (HP:0002293)2.38668760
72Protrusio acetabuli (HP:0003179)2.35387814
73Joint stiffness (HP:0001387)2.32710593
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32659303
75Increased cerebral lipofuscin (HP:0011813)2.30089667
76Tetany (HP:0001281)2.28579902
77Protruding tongue (HP:0010808)2.27748444
78Increased corneal curvature (HP:0100692)2.25989010
79Keratoconus (HP:0000563)2.25989010
80Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25362112
81Abnormality of potassium homeostasis (HP:0011042)2.24609004
82Vacuolated lymphocytes (HP:0001922)2.23831386
83Broad metatarsal (HP:0001783)2.22465794
84Bulbous nose (HP:0000414)2.21428854
85Cardiovascular calcification (HP:0011915)2.20822017
86Dysmetric saccades (HP:0000641)2.20768635
87Vascular calcification (HP:0004934)2.17599975
88Wormian bones (HP:0002645)2.17064497
89Sclerocornea (HP:0000647)2.16652800
90Fragile skin (HP:0001030)2.15238770
91Platyspondyly (HP:0000926)2.14228309
92Amelogenesis imperfecta (HP:0000705)2.13158100
93Impaired smooth pursuit (HP:0007772)2.11913332
94Retinal dysplasia (HP:0007973)2.11378751
95Macular degeneration (HP:0000608)2.09645578
96Abnormality of the pubic bones (HP:0003172)2.09493841
97Pustule (HP:0200039)2.09278034
98Postural instability (HP:0002172)2.08491094
99Hypokalemia (HP:0002900)2.08487126
100Metaphyseal dysplasia (HP:0100255)2.08210069
101Vertebral compression fractures (HP:0002953)2.07230849
102Renovascular hypertension (HP:0100817)2.05687860
103Flat capital femoral epiphysis (HP:0003370)2.05201050
104Type II lissencephaly (HP:0007260)2.04725404
105Premature skin wrinkling (HP:0100678)2.04040581
106Large for gestational age (HP:0001520)2.03791419
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02883615
108Tubular atrophy (HP:0000092)2.02462595
109Abnormality of subcutaneous fat tissue (HP:0001001)2.00729924
110Thoracolumbar scoliosis (HP:0002944)1.99727504
111Abnormal urine output (HP:0012590)1.99518995
112Flattened epiphyses (HP:0003071)1.99359335
113Fat malabsorption (HP:0002630)1.96829813
114Abnormality of macular pigmentation (HP:0008002)1.96515188
115Rectal prolapse (HP:0002035)1.96386503
116Interstitial pulmonary disease (HP:0006530)1.95794408
117Osteoarthritis (HP:0002758)1.95213983
118Abnormality of the vertebral endplates (HP:0005106)1.94432885
119Rhinitis (HP:0012384)1.92973644
120Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.92272854
121Inability to walk (HP:0002540)1.91847147
122Irregular vertebral endplates (HP:0003301)1.91108242
123Anhidrosis (HP:0000970)1.90520043
124Pulmonary artery stenosis (HP:0004415)1.89860090
125Asymmetric septal hypertrophy (HP:0001670)1.89794286
126Enlarged epiphyses (HP:0010580)1.88850720
127Stage 5 chronic kidney disease (HP:0003774)1.88330881
128Congenital hepatic fibrosis (HP:0002612)1.86074493
129Glomerulosclerosis (HP:0000096)1.85783898
130Nephritis (HP:0000123)1.85028325
131Abnormality of the diencephalon (HP:0010662)1.84969164
132Axonal loss (HP:0003447)1.83013367
133Adrenal overactivity (HP:0002717)1.82145900
134Alkalosis (HP:0001948)1.81612329
135Hypoplasia of the odontoid process (HP:0003311)1.81379245
136Mesangial abnormality (HP:0001966)1.81142402
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80724407
138Chorioretinal atrophy (HP:0000533)1.80308329
139Barrel-shaped chest (HP:0001552)1.79985645
140Corneal erosion (HP:0200020)1.79004667
141Chondrocalcinosis (HP:0000934)1.78646437
142Hypoplasia of the iris (HP:0007676)1.78054645
143Abnormality of renin-angiotensin system (HP:0000847)1.77096129
144Oligodontia (HP:0000677)1.76999002
145Periodontitis (HP:0000704)1.76943327
146Hyperparathyroidism (HP:0000843)1.76113330
147Genu varum (HP:0002970)1.75819135
148Short chin (HP:0000331)1.75654909
149Abolished electroretinogram (ERG) (HP:0000550)1.74825257
150Submucous cleft hard palate (HP:0000176)1.74817494
151Depressed nasal tip (HP:0000437)1.73931739
152Vascular tortuosity (HP:0004948)1.73159914
153Abnormality of Sharpey fibers (HP:0100685)1.72768775
154Gout (HP:0001997)1.71548988
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70967172
156Osteolytic defects of the hand bones (HP:0009699)1.70935586
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.70935586
158Polyuria (HP:0000103)1.70776720
159Metaphyseal cupping (HP:0003021)1.70188177
160Abnormality of the axillary hair (HP:0100134)1.70100042
161Abnormality of secondary sexual hair (HP:0009888)1.70100042
162Abnormal vertebral ossification (HP:0100569)1.69908450
163Type I diabetes mellitus (HP:0100651)1.69886011
164Lip pit (HP:0100267)1.69651600
165Abnormality of the phalanges of the 5th finger (HP:0004213)1.69327912
166Ovoid vertebral bodies (HP:0003300)1.69288480
167Coxa vara (HP:0002812)1.68982815
168Congenital sensorineural hearing impairment (HP:0008527)1.68765093
169Abnormality of the anterior chamber (HP:0000593)1.68124025
170Coxa valga (HP:0002673)1.67708083
171Abnormality of the distal phalanges of the toes (HP:0010182)1.67324415
172Hyperphosphatemia (HP:0002905)1.66989124
173Narrow nasal bridge (HP:0000446)1.62447907
174Abnormal rod and cone electroretinograms (HP:0008323)1.60764411
175Complement deficiency (HP:0004431)1.60488052
176Infertility (HP:0000789)1.59868720
177Furrowed tongue (HP:0000221)1.59002342
178Hyperalaninemia (HP:0003348)1.58499244
179Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.58499244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.69523464
2MST44.10814937
3SIK13.71039847
4MAP3K32.95304065
5ERN12.85003104
6ACVR1B2.82492491
7EPHA22.67543963
8IRAK32.50263040
9LMTK22.39821384
10BMPR1B2.28636706
11CAMK1G2.28163160
12CAMK1D2.14799340
13SIK22.03780345
14AKT32.02094978
15MAP2K22.01608627
16STK382.01259014
17BCKDK2.01144295
18ADRBK21.93281026
19TLK11.89124130
20ERBB31.87530998
21PNCK1.79367158
22EPHB21.77001087
23PRKG21.76341775
24EPHA31.75635399
25FER1.66338638
26TGFBR21.60797383
27LATS11.60511591
28MARK31.57133022
29TRIB31.56275392
30STK38L1.52667176
31PRKD31.49872502
32DDR21.45548986
33MAP3K141.45115431
34INSRR1.38391375
35FRK1.37851385
36PIM21.35100978
37TRPM71.34474156
38NME21.34146959
39CASK1.33036702
40MST1R1.31528713
41RPS6KA41.31050861
42EIF2AK31.27358869
43RPS6KB21.24636438
44STK101.20170957
45TAOK11.19847958
46TBK11.18250048
47TGFBR11.13777039
48LRRK21.09798169
49NTRK31.07765865
50ZAP701.07622162
51WNK11.05818586
52PRKAA21.05675428
53TNK21.05398378
54PTK2B1.05136853
55MAP2K31.04299366
56SGK31.04067726
57PKN11.03022894
58IKBKE1.01649402
59TAOK20.99517729
60PINK10.99501015
61EPHB10.95144282
62TAOK30.95138991
63STK390.94834067
64PDK20.94443750
65MAP2K10.93408141
66MAPK150.92866540
67KIT0.92299123
68CDC42BPA0.92165963
69NEK90.91962055
70MAPKAPK30.91371506
71MAP2K60.91297979
72PRKD20.90253468
73RPS6KA60.89447691
74TESK10.89320865
75SGK2230.87854473
76SGK4940.87854473
77ZAK0.87297744
78PIK3CA0.87187714
79IKBKB0.86497006
80MARK20.84496551
81MAPK130.84343177
82PLK40.83429135
83CAMK10.83236401
84ICK0.83138354
85MUSK0.80421672
86IRAK40.79103626
87TEC0.78311937
88HIPK20.77646832
89PRKAA10.75719291
90NUAK10.75667172
91PDGFRB0.75257396
92CDK60.74548705
93NEK20.72501175
94PRKCG0.71831653
95CHUK0.71657214
96RPS6KA20.71379818
97MAP3K20.66663600
98CAMKK10.66434226
99RIPK10.65078507
100PTK20.64633785
101PRKCH0.64498090
102MAP4K20.63975953
103BMPR20.63666764
104WNK40.62767141
105PHKG20.62160903
106PHKG10.62160903
107TYRO30.61597389
108PTK60.61185294
109PDPK10.60746271
110STK240.60642130
111PRKCE0.59845099
112MAP3K110.59660571
113IRAK10.59549603
114MTOR0.59462918
115JAK10.57136655
116ADRBK10.55684342
117PRKCI0.54834743
118SGK20.54689099
119ABL20.54661393
120PIK3CG0.53786206
121MAP3K70.53499814
122MET0.53032298
123PAK30.52333973
124BMX0.51889386
125EIF2AK20.49967461
126NME10.49709245
127PIM10.49198079
128STK30.48604594
129PBK0.48427348
130MAPKAPK50.45704013
131GRK10.44484938
132MAP3K10.44445020
133PRKG10.43319334
134PAK40.42912442
135PAK20.42646076
136MARK10.42390488
137BLK0.41848288
138SGK10.41614428
139TIE10.41138662
140PRKCZ0.40184271
141RIPK40.39146956
142RPS6KC10.38614871
143RPS6KL10.38614871
144ERBB20.37276081
145PRKCA0.36175900
146PRKACA0.34805851
147MAPK110.34580909
148PDK10.34472024
149ROCK10.33752283
150NEK60.32665610
151GRK70.31983574
152MAPK80.31956517
153CSK0.31849414
154CAMK40.31540334
155ABL10.30610186
156PDGFRA0.30198007
157MAPK10.30013697
158IGF1R0.29274777
159MAPK70.29215472
160MYLK0.28024152
161DAPK20.27619334

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049724.42066091
2Protein digestion and absorption_Homo sapiens_hsa049744.09273665
3Protein export_Homo sapiens_hsa030602.85943615
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.78307478
5Fat digestion and absorption_Homo sapiens_hsa049752.77221433
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.74763516
7Chemical carcinogenesis_Homo sapiens_hsa052042.56760928
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.36588562
9Fatty acid biosynthesis_Homo sapiens_hsa000612.18277731
10Tryptophan metabolism_Homo sapiens_hsa003802.12036645
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.07704045
12Butanoate metabolism_Homo sapiens_hsa006502.03267187
13Nicotine addiction_Homo sapiens_hsa050332.02855016
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99432040
15Sulfur metabolism_Homo sapiens_hsa009201.93328052
16ECM-receptor interaction_Homo sapiens_hsa045121.88846791
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87301291
18Other glycan degradation_Homo sapiens_hsa005111.76416038
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74417618
20ABC transporters_Homo sapiens_hsa020101.71741069
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.68682146
22Nitrogen metabolism_Homo sapiens_hsa009101.66072069
23Morphine addiction_Homo sapiens_hsa050321.59359302
24Taste transduction_Homo sapiens_hsa047421.58571056
25Folate biosynthesis_Homo sapiens_hsa007901.57551880
26Legionellosis_Homo sapiens_hsa051341.57066813
27Glycerolipid metabolism_Homo sapiens_hsa005611.55248370
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53475659
29Tyrosine metabolism_Homo sapiens_hsa003501.47188754
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40848957
31PPAR signaling pathway_Homo sapiens_hsa033201.40308802
32Rheumatoid arthritis_Homo sapiens_hsa053231.36902748
33Steroid biosynthesis_Homo sapiens_hsa001001.36707205
34Vibrio cholerae infection_Homo sapiens_hsa051101.36675071
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36397744
36Phototransduction_Homo sapiens_hsa047441.34918812
37Lysosome_Homo sapiens_hsa041421.34121270
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.33420972
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33355727
40Malaria_Homo sapiens_hsa051441.31641393
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31423552
42Arachidonic acid metabolism_Homo sapiens_hsa005901.30077817
43Complement and coagulation cascades_Homo sapiens_hsa046101.29131831
44Serotonergic synapse_Homo sapiens_hsa047261.27999057
45Leishmaniasis_Homo sapiens_hsa051401.27850922
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25484249
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.25172555
48Retinol metabolism_Homo sapiens_hsa008301.24690859
49GABAergic synapse_Homo sapiens_hsa047271.24273982
50TNF signaling pathway_Homo sapiens_hsa046681.23324603
51Circadian entrainment_Homo sapiens_hsa047131.23228799
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22575518
53Vitamin digestion and absorption_Homo sapiens_hsa049771.21443132
54Glutamatergic synapse_Homo sapiens_hsa047241.20572705
55Sphingolipid metabolism_Homo sapiens_hsa006001.14949569
56Phenylalanine metabolism_Homo sapiens_hsa003601.14918048
57Lysine degradation_Homo sapiens_hsa003101.12031363
58Histidine metabolism_Homo sapiens_hsa003401.11132215
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09917387
60Renin-angiotensin system_Homo sapiens_hsa046141.09106031
61Calcium signaling pathway_Homo sapiens_hsa040201.07817297
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03008313
63Bile secretion_Homo sapiens_hsa049761.02531753
64Insulin secretion_Homo sapiens_hsa049111.02078759
65Adherens junction_Homo sapiens_hsa045201.01769861
66Starch and sucrose metabolism_Homo sapiens_hsa005001.01560761
67Ovarian steroidogenesis_Homo sapiens_hsa049131.01121916
68Influenza A_Homo sapiens_hsa051641.00577479
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.99666033
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97884079
71Amoebiasis_Homo sapiens_hsa051460.97777493
72Phagosome_Homo sapiens_hsa041450.97667119
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.96900398
74Olfactory transduction_Homo sapiens_hsa047400.96352198
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.93277024
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92662086
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92648110
78Pertussis_Homo sapiens_hsa051330.92304005
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91600951
80Glutathione metabolism_Homo sapiens_hsa004800.90319326
81Ether lipid metabolism_Homo sapiens_hsa005650.90111881
82Toxoplasmosis_Homo sapiens_hsa051450.89979136
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89345992
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87917121
85beta-Alanine metabolism_Homo sapiens_hsa004100.87438991
86Cholinergic synapse_Homo sapiens_hsa047250.85857377
87Type II diabetes mellitus_Homo sapiens_hsa049300.85617194
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84947271
89Cocaine addiction_Homo sapiens_hsa050300.84794762
90Focal adhesion_Homo sapiens_hsa045100.84261886
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83967159
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82138532
93Linoleic acid metabolism_Homo sapiens_hsa005910.82106179
94Gastric acid secretion_Homo sapiens_hsa049710.81820909
95Arginine and proline metabolism_Homo sapiens_hsa003300.81508391
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81251655
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.79699766
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79177930
99Fatty acid degradation_Homo sapiens_hsa000710.77717459
100Mineral absorption_Homo sapiens_hsa049780.77020425
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76714346
102Salivary secretion_Homo sapiens_hsa049700.75921661
103Dorso-ventral axis formation_Homo sapiens_hsa043200.75102699
104Tuberculosis_Homo sapiens_hsa051520.74844119
105Oxytocin signaling pathway_Homo sapiens_hsa049210.73847360
106Peroxisome_Homo sapiens_hsa041460.68733616
107Proteoglycans in cancer_Homo sapiens_hsa052050.67908636
108Sulfur relay system_Homo sapiens_hsa041220.67450356
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66482084
110cAMP signaling pathway_Homo sapiens_hsa040240.62512609
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.62082028
112Apoptosis_Homo sapiens_hsa042100.61093336
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.59084843
114Small cell lung cancer_Homo sapiens_hsa052220.58793538
115Arginine biosynthesis_Homo sapiens_hsa002200.57680435
116Bladder cancer_Homo sapiens_hsa052190.57598358
117Hematopoietic cell lineage_Homo sapiens_hsa046400.57500430
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57484923
119TGF-beta signaling pathway_Homo sapiens_hsa043500.57395387
120Galactose metabolism_Homo sapiens_hsa000520.56843788
121Renin secretion_Homo sapiens_hsa049240.56614024
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55636338
123Salmonella infection_Homo sapiens_hsa051320.54875970
124Osteoclast differentiation_Homo sapiens_hsa043800.54701849
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52160116
126Dopaminergic synapse_Homo sapiens_hsa047280.52119718
127Circadian rhythm_Homo sapiens_hsa047100.50035348
128Selenocompound metabolism_Homo sapiens_hsa004500.48862296
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48552055
130Tight junction_Homo sapiens_hsa045300.48431874
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48075002
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47779960
133African trypanosomiasis_Homo sapiens_hsa051430.46036040
134Notch signaling pathway_Homo sapiens_hsa043300.45589658
135Collecting duct acid secretion_Homo sapiens_hsa049660.44999977
136Long-term depression_Homo sapiens_hsa047300.44408695
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44132262
138Prostate cancer_Homo sapiens_hsa052150.44117763
139Insulin resistance_Homo sapiens_hsa049310.43905714
140Measles_Homo sapiens_hsa051620.43079572
141Hepatitis C_Homo sapiens_hsa051600.42103454
142N-Glycan biosynthesis_Homo sapiens_hsa005100.41770228
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41691985
144Fatty acid metabolism_Homo sapiens_hsa012120.40282655
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39576035
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39389202
147Graft-versus-host disease_Homo sapiens_hsa053320.39077575
148MAPK signaling pathway_Homo sapiens_hsa040100.38410848
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38340113
150Estrogen signaling pathway_Homo sapiens_hsa049150.37307393
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37091333
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37020084
153Staphylococcus aureus infection_Homo sapiens_hsa051500.36933473
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.35962154
155Caffeine metabolism_Homo sapiens_hsa002320.35572753
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35048440
157Asthma_Homo sapiens_hsa053100.34940016
158Melanoma_Homo sapiens_hsa052180.33213910
159Viral myocarditis_Homo sapiens_hsa054160.32567544
160Chronic myeloid leukemia_Homo sapiens_hsa052200.31536960

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