NUP93

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.05825379
2DNA replication initiation (GO:0006270)4.82051743
3DNA strand elongation involved in DNA replication (GO:0006271)4.77322930
4* nuclear pore organization (GO:0006999)4.62909803
5protein localization to kinetochore (GO:0034501)4.58479366
6DNA strand elongation (GO:0022616)4.51377377
7establishment of integrated proviral latency (GO:0075713)4.47749339
8* nuclear pore complex assembly (GO:0051292)4.38260756
9telomere maintenance via semi-conservative replication (GO:0032201)4.33286623
10* mitotic nuclear envelope disassembly (GO:0007077)4.29515093
11synapsis (GO:0007129)4.28678249
12DNA replication-dependent nucleosome assembly (GO:0006335)4.25448590
13DNA replication-dependent nucleosome organization (GO:0034723)4.25448590
14mitotic metaphase plate congression (GO:0007080)4.19026078
15folic acid-containing compound biosynthetic process (GO:0009396)4.18439680
16DNA replication checkpoint (GO:0000076)4.16678243
17nucleobase biosynthetic process (GO:0046112)4.07571567
18IMP biosynthetic process (GO:0006188)4.05044687
19* membrane disassembly (GO:0030397)4.01822196
20* nuclear envelope disassembly (GO:0051081)4.01822196
21telomere maintenance via recombination (GO:0000722)3.95286770
22mitotic chromosome condensation (GO:0007076)3.90004208
23mitotic recombination (GO:0006312)3.89128766
24proteasome assembly (GO:0043248)3.85111977
25protein localization to chromosome, centromeric region (GO:0071459)3.79361631
26kinetochore organization (GO:0051383)3.78672117
27formation of translation preinitiation complex (GO:0001731)3.75531512
28metaphase plate congression (GO:0051310)3.72521848
29mitotic sister chromatid segregation (GO:0000070)3.69052713
30chromatin remodeling at centromere (GO:0031055)3.68112024
31purine nucleobase biosynthetic process (GO:0009113)3.66665772
32telomere maintenance via telomere lengthening (GO:0010833)3.63615117
33CENP-A containing nucleosome assembly (GO:0034080)3.62970333
34DNA ligation (GO:0006266)3.59305979
35double-strand break repair via nonhomologous end joining (GO:0006303)3.54706231
36non-recombinational repair (GO:0000726)3.54706231
37maturation of SSU-rRNA (GO:0030490)3.53436738
38regulation of spindle organization (GO:0090224)3.51387900
39DNA replication-independent nucleosome organization (GO:0034724)3.51005034
40DNA replication-independent nucleosome assembly (GO:0006336)3.51005034
41establishment of viral latency (GO:0019043)3.50984107
42ribosome assembly (GO:0042255)3.50886771
43sister chromatid segregation (GO:0000819)3.49892233
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.48597373
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46409352
46DNA duplex unwinding (GO:0032508)3.46298741
47DNA geometric change (GO:0032392)3.44842582
48attachment of spindle microtubules to kinetochore (GO:0008608)3.44748080
49establishment of chromosome localization (GO:0051303)3.44398278
50IMP metabolic process (GO:0046040)3.43641330
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42583365
52resolution of meiotic recombination intermediates (GO:0000712)3.41724310
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40468823
54regulation of mitochondrial translation (GO:0070129)3.39656467
55kinetochore assembly (GO:0051382)3.35866044
56positive regulation of chromosome segregation (GO:0051984)3.35544140
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35401640
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34004043
59DNA double-strand break processing (GO:0000729)3.33803513
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32684967
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.32684967
62regulation of mitotic spindle organization (GO:0060236)3.32582824
63* pore complex assembly (GO:0046931)3.31201936
64ribosome biogenesis (GO:0042254)3.30796579
65regulation of gene silencing by RNA (GO:0060966)3.27187492
66regulation of posttranscriptional gene silencing (GO:0060147)3.27187492
67regulation of gene silencing by miRNA (GO:0060964)3.27187492
68cullin deneddylation (GO:0010388)3.25812263
69histone H2A acetylation (GO:0043968)3.24984017
70negative regulation of chromosome segregation (GO:0051985)3.24411299
71spindle checkpoint (GO:0031577)3.21279861
72regulation of centrosome cycle (GO:0046605)3.21204438
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19448473
74negative regulation of sister chromatid segregation (GO:0033046)3.19448473
75negative regulation of mitotic sister chromatid separation (GO:2000816)3.19448473
76negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19448473
77spindle assembly checkpoint (GO:0071173)3.17722943
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16757941
79negative regulation of ligase activity (GO:0051352)3.16757941
80regulation of chromosome segregation (GO:0051983)3.16487853
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16315416
82mitotic spindle assembly checkpoint (GO:0007094)3.16196260
83DNA catabolic process, exonucleolytic (GO:0000738)3.15135866
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15079431
85mitotic spindle checkpoint (GO:0071174)3.13570797
86tRNA aminoacylation (GO:0043039)3.12842877
87amino acid activation (GO:0043038)3.12842877
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12309558
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12099517
90histone exchange (GO:0043486)3.12088506
91DNA synthesis involved in DNA repair (GO:0000731)3.12078552
92tRNA aminoacylation for protein translation (GO:0006418)3.11923295
93negative regulation of DNA recombination (GO:0045910)3.11018785
94* nuclear envelope organization (GO:0006998)3.07659659
95L-serine metabolic process (GO:0006563)3.07055166
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06793067
97spliceosomal snRNP assembly (GO:0000387)3.06066588
98chromosome organization involved in meiosis (GO:0070192)3.03826323
99mitotic sister chromatid cohesion (GO:0007064)3.03393232
100histone arginine methylation (GO:0034969)3.03319707
101negative regulation of histone methylation (GO:0031061)3.02423226
102peptidyl-arginine omega-N-methylation (GO:0035247)3.02141698
103regulation of centriole replication (GO:0046599)3.02064356
104meiotic chromosome segregation (GO:0045132)3.01912933
105protein deneddylation (GO:0000338)3.01888778
106ribonucleoprotein complex biogenesis (GO:0022613)3.01772977
107piRNA metabolic process (GO:0034587)3.01541980
108regulation of double-strand break repair via homologous recombination (GO:0010569)3.00853802
109chromatin assembly or disassembly (GO:0006333)3.00604962
110regulation of histone H3-K9 methylation (GO:0051570)3.00444999
111DNA topological change (GO:0006265)2.99482100
112heterochromatin organization (GO:0070828)2.99305548
113protein K6-linked ubiquitination (GO:0085020)2.97228388
114ribosomal large subunit biogenesis (GO:0042273)2.95875390
115regulation of mitotic sister chromatid separation (GO:0010965)2.95744980
116regulation of mitotic sister chromatid segregation (GO:0033047)2.95744980
117regulation of sister chromatid segregation (GO:0033045)2.95744980
118ribosomal small subunit assembly (GO:0000028)2.94653478
119postreplication repair (GO:0006301)2.93580845
120protein localization to chromosome (GO:0034502)2.93574336
121mismatch repair (GO:0006298)2.92049410
122RNA splicing, via transesterification reactions (GO:0000375)2.91514669
123telomere maintenance (GO:0000723)2.91039583
124chromosome segregation (GO:0007059)2.90587391
125viral mRNA export from host cell nucleus (GO:0046784)2.90486206
126rRNA processing (GO:0006364)2.90136932
127peptidyl-arginine methylation (GO:0018216)2.90077545
128peptidyl-arginine N-methylation (GO:0035246)2.90077545
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.90044496
130mRNA splicing, via spliceosome (GO:0000398)2.90044496
131transcription-coupled nucleotide-excision repair (GO:0006283)2.89638844
132regulation of translational fidelity (GO:0006450)2.89494629
133telomere organization (GO:0032200)2.89471702
134ATP-dependent chromatin remodeling (GO:0043044)2.88584069
135replication fork processing (GO:0031297)2.87234270
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85811847
137regulation of mitotic spindle checkpoint (GO:1903504)2.85811847
138positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81234893
139base-excision repair (GO:0006284)2.80510091
140pseudouridine synthesis (GO:0001522)2.80163587
141DNA damage response, detection of DNA damage (GO:0042769)2.79361237
142regulation of helicase activity (GO:0051095)2.77739594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.68995064
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.27308595
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95550667
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45518049
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26752531
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13953625
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80658110
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66999377
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64833074
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.61681237
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48532927
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47841870
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.43344781
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.34193986
15* XRN2_22483619_ChIP-Seq_HELA_Human2.32810585
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30544189
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.30541329
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27392095
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27276704
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25453585
21AR_21909140_ChIP-Seq_LNCAP_Human2.25044127
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21351297
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.17149419
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16838968
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12145747
26E2F7_22180533_ChIP-Seq_HELA_Human10.0353298
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94970775
28VDR_23849224_ChIP-Seq_CD4+_Human1.93637986
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90289029
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89139875
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87920035
32TTF2_22483619_ChIP-Seq_HELA_Human1.84890341
33DCP1A_22483619_ChIP-Seq_HELA_Human1.82396859
34FOXP3_21729870_ChIP-Seq_TREG_Human1.78031055
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75248686
36GABP_19822575_ChIP-Seq_HepG2_Human1.70645656
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70570216
38MYC_22102868_ChIP-Seq_BL_Human1.70020471
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69248938
40CIITA_25753668_ChIP-Seq_RAJI_Human1.63124233
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58597565
42ELK1_19687146_ChIP-ChIP_HELA_Human1.55185424
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54982446
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54575679
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54265566
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53513548
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52908435
48ZNF274_21170338_ChIP-Seq_K562_Hela1.51431267
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50946106
50KDM5A_27292631_Chip-Seq_BREAST_Human1.44700258
51* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43826456
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43195621
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.41618172
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41285626
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40285842
56* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40012575
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36860667
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36719050
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35609368
60IGF1R_20145208_ChIP-Seq_DFB_Human1.33643146
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.33266101
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.33082494
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32311151
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31196775
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30123902
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28367055
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.25204805
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23694562
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23694562
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23694562
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22702460
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21520151
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21518142
74TFEB_21752829_ChIP-Seq_HELA_Human1.20933038
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19112543
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15054002
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.13457959
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11742866
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11420213
80EWS_26573619_Chip-Seq_HEK293_Human1.10459790
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09814265
82* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08831048
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08474561
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08350992
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07766160
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07328360
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05200708
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04495429
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04207612
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04024608
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.00282499
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99761964
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.98836095
94IRF1_19129219_ChIP-ChIP_H3396_Human0.98457554
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98129527
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.98083606
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96779087
98MYC_18940864_ChIP-ChIP_HL60_Human0.95788068
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95637880
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95453412
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95122132
102* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94699441
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94607364
104FUS_26573619_Chip-Seq_HEK293_Human0.94530097
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93959962
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90020721
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88765290
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87185724
109* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85841722
110VDR_21846776_ChIP-Seq_THP-1_Human0.84308631
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84194480
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82827814
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82752775
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82661561
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82489026
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81954274
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80908062
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80679937
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.78409216
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76123287
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73867796
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.70136442
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67007686
124* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.64884803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.80105877
2MP0003693_abnormal_embryo_hatching4.73772768
3MP0003111_abnormal_nucleus_morphology4.48080865
4MP0004957_abnormal_blastocyst_morpholog4.23208464
5MP0008057_abnormal_DNA_replication4.06948851
6MP0003077_abnormal_cell_cycle3.95088265
7MP0008058_abnormal_DNA_repair3.21272982
8MP0008007_abnormal_cellular_replicative2.94228233
9MP0008932_abnormal_embryonic_tissue2.78199349
10MP0001730_embryonic_growth_arrest2.58772659
11MP0003123_paternal_imprinting2.49363435
12MP0010352_gastrointestinal_tract_polyps2.40857664
13MP0000350_abnormal_cell_proliferation2.39020738
14MP0008877_abnormal_DNA_methylation2.32997331
15MP0001529_abnormal_vocalization2.21572008
16MP0010030_abnormal_orbit_morphology2.19369640
17MP0010307_abnormal_tumor_latency2.07123017
18MP0009697_abnormal_copulation2.05699239
19MP0003786_premature_aging2.01152220
20MP0006035_abnormal_mitochondrial_morpho1.97337330
21MP0002396_abnormal_hematopoietic_system1.94694807
22MP0001697_abnormal_embryo_size1.91301545
23MP0005380_embryogenesis_phenotype1.90506064
24MP0001672_abnormal_embryogenesis/_devel1.90506064
25MP0002085_abnormal_embryonic_tissue1.78576504
26MP0002084_abnormal_developmental_patter1.78121830
27MP0003121_genomic_imprinting1.73865850
28MP0003984_embryonic_growth_retardation1.71038425
29MP0002080_prenatal_lethality1.68032711
30MP0002088_abnormal_embryonic_growth/wei1.67632185
31MP0005394_taste/olfaction_phenotype1.65097169
32MP0005499_abnormal_olfactory_system1.65097169
33MP0004197_abnormal_fetal_growth/weight/1.59979210
34MP0002086_abnormal_extraembryonic_tissu1.52247390
35MP0005076_abnormal_cell_differentiation1.46642729
36MP0003567_abnormal_fetal_cardiomyocyte1.45914068
37MP0001188_hyperpigmentation1.45396898
38MP0003890_abnormal_embryonic-extraembry1.43070043
39MP0009053_abnormal_anal_canal1.42863346
40MP0000313_abnormal_cell_death1.40930662
41MP0000490_abnormal_crypts_of1.36892993
42MP0003122_maternal_imprinting1.32022662
43MP0002210_abnormal_sex_determination1.31188160
44MP0002653_abnormal_ependyma_morphology1.27882488
45MP0002736_abnormal_nociception_after1.27129023
46MP0002019_abnormal_tumor_incidence1.26876658
47MP0004808_abnormal_hematopoietic_stem1.21619431
48MP0003718_maternal_effect1.20738251
49MP0000537_abnormal_urethra_morphology1.20477423
50MP0003698_abnormal_male_reproductive1.19719469
51MP0001293_anophthalmia1.19172609
52MP0006292_abnormal_olfactory_placode1.15986086
53MP0004147_increased_porphyrin_level1.15653001
54MP0003136_yellow_coat_color1.14207406
55MP0001145_abnormal_male_reproductive1.13238199
56MP0003221_abnormal_cardiomyocyte_apopto1.12835163
57MP0003119_abnormal_digestive_system1.09566859
58MP0004133_heterotaxia1.08983470
59MP0002233_abnormal_nose_morphology1.05239993
60MP0003315_abnormal_perineum_morphology1.04849770
61MP0005423_abnormal_somatic_nervous1.02508968
62MP0000372_irregular_coat_pigmentation1.00201326
63MP0003937_abnormal_limbs/digits/tail_de0.99460298
64MP0006054_spinal_hemorrhage0.98595146
65MP0000778_abnormal_nervous_system0.98401621
66MP0002160_abnormal_reproductive_system0.96609567
67MP0001915_intracranial_hemorrhage0.96559162
68MP0006036_abnormal_mitochondrial_physio0.95892410
69MP0003941_abnormal_skin_development0.95883381
70MP0005645_abnormal_hypothalamus_physiol0.95249959
71MP0002234_abnormal_pharynx_morphology0.95162842
72MP0006072_abnormal_retinal_apoptosis0.93931229
73MP0000653_abnormal_sex_gland0.93310125
74MP0003566_abnormal_cell_adhesion0.91969077
75MP0006276_abnormal_autonomic_nervous0.91882746
76MP0000703_abnormal_thymus_morphology0.91768675
77MP0000428_abnormal_craniofacial_morphol0.91450524
78MP0001929_abnormal_gametogenesis0.90630528
79MP0002111_abnormal_tail_morphology0.90628902
80MP0003186_abnormal_redox_activity0.90132096
81MP0001984_abnormal_olfaction0.89921621
82MP0003705_abnormal_hypodermis_morpholog0.88407065
83MP0003880_abnormal_central_pattern0.88192019
84MP0002751_abnormal_autonomic_nervous0.87582480
85MP0009672_abnormal_birth_weight0.85723511
86MP0002161_abnormal_fertility/fecundity0.85471022
87MP0009333_abnormal_splenocyte_physiolog0.85171764
88MP0003806_abnormal_nucleotide_metabolis0.85011681
89MP0003385_abnormal_body_wall0.84600276
90MP0001968_abnormal_touch/_nociception0.83485423
91MP0002184_abnormal_innervation0.83341345
92MP0005384_cellular_phenotype0.80425808
93MP0005397_hematopoietic_system_phenotyp0.80425314
94MP0001545_abnormal_hematopoietic_system0.80425314
95MP0000631_abnormal_neuroendocrine_gland0.80274909
96MP0009703_decreased_birth_body0.77791197
97MP0005023_abnormal_wound_healing0.77306314
98MP0000647_abnormal_sebaceous_gland0.77158969
99MP0008995_early_reproductive_senescence0.76738568
100MP0002938_white_spotting0.75734883
101MP0005621_abnormal_cell_physiology0.75576399
102MP0003283_abnormal_digestive_organ0.75381889
103MP0003861_abnormal_nervous_system0.75317951
104MP0000858_altered_metastatic_potential0.74644561
105MP0000358_abnormal_cell_content/0.73390146
106MP0000955_abnormal_spinal_cord0.73375108
107MP0001119_abnormal_female_reproductive0.70906814
108MP0004811_abnormal_neuron_physiology0.70889909
109MP0001849_ear_inflammation0.70879129
110MP0005253_abnormal_eye_physiology0.69493452
111MP0002925_abnormal_cardiovascular_devel0.68555791
112MP0002398_abnormal_bone_marrow0.68033782
113MP0003115_abnormal_respiratory_system0.67996839
114MP0000432_abnormal_head_morphology0.67646728
115MP0000733_abnormal_muscle_development0.67314487
116MP0005187_abnormal_penis_morphology0.67193231
117MP0009046_muscle_twitch0.66437709
118MP0002822_catalepsy0.66436092
119MP0009278_abnormal_bone_marrow0.66004143
120MP0003938_abnormal_ear_development0.65606748
121MP0001286_abnormal_eye_development0.65455212
122MP0002697_abnormal_eye_size0.65452136
123MP0005389_reproductive_system_phenotype0.65435725
124MP0003935_abnormal_craniofacial_develop0.65177688
125MP0002152_abnormal_brain_morphology0.65054292
126MP0005391_vision/eye_phenotype0.65035865
127MP0003755_abnormal_palate_morphology0.65006767
128MP0008770_decreased_survivor_rate0.64746689
129MP0000516_abnormal_urinary_system0.64106555
130MP0005367_renal/urinary_system_phenotyp0.64106555
131MP0002722_abnormal_immune_system0.63611956
132MP0003763_abnormal_thymus_physiology0.63430335
133MP0008789_abnormal_olfactory_epithelium0.62565533
134MP0000049_abnormal_middle_ear0.62175569
135MP0002877_abnormal_melanocyte_morpholog0.61232907
136MP0004233_abnormal_muscle_weight0.60974409
137MP0003942_abnormal_urinary_system0.60415701
138MP0003936_abnormal_reproductive_system0.58928248
139MP0002102_abnormal_ear_morphology0.57563698
140MP0000477_abnormal_intestine_morphology0.57533174

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.22412739
2Chromsome breakage (HP:0040012)3.85164366
3Ependymoma (HP:0002888)3.78374722
4Abnormality of the labia minora (HP:0012880)3.60288367
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58447191
6Breast hypoplasia (HP:0003187)3.47584103
7Selective tooth agenesis (HP:0001592)3.43793343
8Medulloblastoma (HP:0002885)3.38671519
9Colon cancer (HP:0003003)3.31001336
10Reticulocytopenia (HP:0001896)3.29619877
11Patellar aplasia (HP:0006443)3.24556170
12Cortical dysplasia (HP:0002539)3.11363996
13Abnormality of the anterior horn cell (HP:0006802)3.09844369
14Degeneration of anterior horn cells (HP:0002398)3.09844369
15Aplasia/Hypoplasia of the patella (HP:0006498)2.99112339
16Abnormality of chromosome stability (HP:0003220)2.98625644
17Meckel diverticulum (HP:0002245)2.98231001
18Facial hemangioma (HP:0000329)2.90423277
19Abnormality of the preputium (HP:0100587)2.87581017
20Abnormality of the ileum (HP:0001549)2.84840922
21Ectopic kidney (HP:0000086)2.84808464
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.84583899
23Agnosia (HP:0010524)2.78641626
24Oral leukoplakia (HP:0002745)2.77242394
25Duodenal stenosis (HP:0100867)2.69228257
26Small intestinal stenosis (HP:0012848)2.69228257
27Rhabdomyosarcoma (HP:0002859)2.67198778
28Abnormal number of incisors (HP:0011064)2.65859875
29Absent radius (HP:0003974)2.65755839
30Abnormality of the astrocytes (HP:0100707)2.64038350
31Astrocytoma (HP:0009592)2.64038350
32Carpal bone hypoplasia (HP:0001498)2.60977926
33Absent thumb (HP:0009777)2.60265882
34Increased nuchal translucency (HP:0010880)2.54146026
35Abnormal lung lobation (HP:0002101)2.53405100
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52648588
37Short 4th metacarpal (HP:0010044)2.52648588
38Deviation of the thumb (HP:0009603)2.49099584
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.49041575
40Microvesicular hepatic steatosis (HP:0001414)2.48961680
41Proximal placement of thumb (HP:0009623)2.47209739
42Aplasia involving forearm bones (HP:0009822)2.46804920
43Absent forearm bone (HP:0003953)2.46804920
44Retinal dysplasia (HP:0007973)2.45691816
45Myelodysplasia (HP:0002863)2.43232808
46Shoulder girdle muscle weakness (HP:0003547)2.42701523
47Glioma (HP:0009733)2.37762328
48Acute necrotizing encephalopathy (HP:0006965)2.35697846
49Neoplasm of the pancreas (HP:0002894)2.34874215
50Impulsivity (HP:0100710)2.34264719
5111 pairs of ribs (HP:0000878)2.33062237
52Sloping forehead (HP:0000340)2.31599381
53Abnormal mitochondria in muscle tissue (HP:0008316)2.30576181
54Abnormality of the duodenum (HP:0002246)2.28430067
55Basal cell carcinoma (HP:0002671)2.28022006
56Abnormality of glycolysis (HP:0004366)2.27645640
57Amaurosis fugax (HP:0100576)2.27418192
58Acute encephalopathy (HP:0006846)2.27236826
59Supernumerary spleens (HP:0009799)2.26033918
60Atresia of the external auditory canal (HP:0000413)2.25650872
61Rough bone trabeculation (HP:0100670)2.24346008
62Increased CSF lactate (HP:0002490)2.24160609
63Tracheoesophageal fistula (HP:0002575)2.23389644
64Missing ribs (HP:0000921)2.22866219
65Increased serum pyruvate (HP:0003542)2.19467699
66Trismus (HP:0000211)2.17335612
67Neoplasm of the oral cavity (HP:0100649)2.15043212
68Premature graying of hair (HP:0002216)2.14823169
69Neoplasm of striated muscle (HP:0009728)2.13998745
70Abnormality of the carotid arteries (HP:0005344)2.13673144
71Horseshoe kidney (HP:0000085)2.13570430
72Hepatocellular necrosis (HP:0001404)2.12364446
73Aplastic anemia (HP:0001915)2.11310184
74Abnormality of abdominal situs (HP:0011620)2.11259293
75Abdominal situs inversus (HP:0003363)2.11259293
76Abnormality of cells of the erythroid lineage (HP:0012130)2.11220008
77Increased serum lactate (HP:0002151)2.11058791
78Volvulus (HP:0002580)2.10101489
79Cafe-au-lait spot (HP:0000957)2.07678528
80Type I transferrin isoform profile (HP:0003642)2.06894507
81High anterior hairline (HP:0009890)2.05699741
82Embryonal renal neoplasm (HP:0011794)2.04672417
83Rib fusion (HP:0000902)2.04642334
84Duplicated collecting system (HP:0000081)2.03761410
85Bone marrow hypocellularity (HP:0005528)2.02906105
86Abnormal number of erythroid precursors (HP:0012131)2.01034536
87Cerebral hypomyelination (HP:0006808)2.00557595
88Multiple enchondromatosis (HP:0005701)1.99116120
89Short thumb (HP:0009778)1.98210797
90Hyperglycinemia (HP:0002154)1.97672630
91Triphalangeal thumb (HP:0001199)1.97140644
92Aplasia/hypoplasia of the humerus (HP:0006507)1.96007669
93Mitochondrial inheritance (HP:0001427)1.95092852
94Bilateral microphthalmos (HP:0007633)1.94650189
95Microretrognathia (HP:0000308)1.94623378
96Lissencephaly (HP:0001339)1.94009967
97Slender long bone (HP:0003100)1.93650492
98Spinal muscular atrophy (HP:0007269)1.93313175
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91345445
100Abnormality of alanine metabolism (HP:0010916)1.91345445
101Hyperalaninemia (HP:0003348)1.91345445
102Hepatic necrosis (HP:0002605)1.89415443
103Hypoplastic pelvis (HP:0008839)1.88416485
104Abnormality of the metopic suture (HP:0005556)1.88281387
105Atrophy/Degeneration involving motor neurons (HP:0007373)1.88222312
106Abnormal protein glycosylation (HP:0012346)1.87667894
107Abnormal glycosylation (HP:0012345)1.87667894
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87667894
109Abnormal protein N-linked glycosylation (HP:0012347)1.87667894
110CNS hypomyelination (HP:0003429)1.84772186
111Squamous cell carcinoma (HP:0002860)1.84330114
112Lipid accumulation in hepatocytes (HP:0006561)1.84292972
113Postnatal microcephaly (HP:0005484)1.82871569
114Prominent nose (HP:0000448)1.82720963
115Fibular aplasia (HP:0002990)1.82506677
116Partial agenesis of the corpus callosum (HP:0001338)1.81319607
117Increased hepatocellular lipid droplets (HP:0006565)1.81288399
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80961113
119Neoplasm of the colon (HP:0100273)1.79777228
120Preaxial hand polydactyly (HP:0001177)1.78579791
121Biliary tract neoplasm (HP:0100574)1.78448761
122Abnormality of the calcaneus (HP:0008364)1.76795022
123Nephroblastoma (Wilms tumor) (HP:0002667)1.76488791
124Facial cleft (HP:0002006)1.76408674
125Cerebral edema (HP:0002181)1.75847210
126Increased density of long bones (HP:0006392)1.75757748
127Cellular immunodeficiency (HP:0005374)1.75052792
128Optic nerve coloboma (HP:0000588)1.73904965
129Ovarian neoplasm (HP:0100615)1.73722862
130Methylmalonic acidemia (HP:0002912)1.72712906
131Malignant gastrointestinal tract tumors (HP:0006749)1.72488481
132Gastrointestinal carcinoma (HP:0002672)1.72488481
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72018971
134Cutaneous melanoma (HP:0012056)1.71809258
135Abnormality of DNA repair (HP:0003254)1.71591596
136Macrocytic anemia (HP:0001972)1.70928433
137Abnormality of the renal collecting system (HP:0004742)1.69529251
138Overlapping toe (HP:0001845)1.69503713
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.69303951
140Pancytopenia (HP:0001876)1.68315550
141Lactic acidosis (HP:0003128)1.68277247
142Spastic diplegia (HP:0001264)1.67617268
143Hypoplasia of the pons (HP:0012110)1.64970598
144Dandy-Walker malformation (HP:0001305)1.64392039
145Methylmalonic aciduria (HP:0012120)1.64330534
146Progressive macrocephaly (HP:0004481)1.64068801
147Prominent metopic ridge (HP:0005487)1.63689741
148Abnormality of cochlea (HP:0000375)1.62000897
149Abnormality of serum amino acid levels (HP:0003112)1.61488041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.79109618
2BUB14.48361275
3WEE13.93138405
4TSSK62.88138908
5NEK22.78759538
6EIF2AK12.68545450
7NEK12.67475729
8VRK22.64267366
9CDK122.60529260
10TTK2.48598318
11TRIM282.44895376
12PBK2.36747570
13PASK2.32086198
14SRPK12.27279264
15PLK42.12087021
16PLK12.09293163
17CDK192.00930330
18ACVR1B2.00751380
19TESK21.94343813
20MAP3K41.91700438
21BRSK21.91097046
22BCR1.90653235
23MAP2K71.86837977
24ATR1.85701729
25MKNK11.82771410
26CDK71.79180149
27PLK31.73321538
28EEF2K1.72605378
29TGFBR11.72363727
30RPS6KB21.70925899
31TLK11.67993959
32BCKDK1.64160634
33AURKB1.62606385
34CSNK1G31.58504738
35BRD41.55898936
36NME11.54791282
37MAP4K21.49913600
38MKNK21.49786519
39NUAK11.48515464
40EPHA21.46098535
41CSNK1A1L1.44663783
42CHEK21.43562530
43CHEK11.41874684
44WNK31.40966386
45MAP3K81.40086377
46CSNK1G21.39367079
47CSNK1G11.36606203
48VRK11.36539565
49STK101.34878347
50BRSK11.33297481
51AURKA1.29475559
52CDK41.26427618
53STK161.23764109
54NME21.22432798
55EIF2AK31.20533946
56RPS6KA41.13443092
57ALK1.11187591
58PAK41.08858881
59SCYL21.08578151
60ATM1.06484898
61TAF11.05828945
62CDK21.00239264
63PDK20.92008526
64TESK10.89895576
65TIE10.88854205
66STK40.88518149
67DYRK30.88237960
68FLT30.87976099
69MARK10.84384077
70BMPR1B0.83034039
71CASK0.82582942
72MAP3K100.82211313
73PNCK0.80856330
74CDK10.77956881
75PKN20.77830405
76ZAK0.77806511
77CDK80.76175544
78PIM10.75539686
79LIMK10.74796058
80CDK60.72091795
81PAK10.70081833
82CSNK2A20.69258453
83STK30.67568283
84MAPK130.67179792
85PRKCI0.66368517
86MTOR0.65678282
87LRRK20.64902993
88CDK180.64788656
89MST40.64672604
90CDK11A0.63353527
91CDK140.63288891
92MELK0.63176379
93DAPK10.62972784
94LATS20.61897939
95CDK150.59859108
96MINK10.58232772
97CSNK2A10.57511007
98OXSR10.55917367
99STK38L0.55851707
100RAF10.53156179
101PIM20.52898689
102ERBB30.50700873
103PLK20.49382534
104CSNK1E0.49354207
105CCNB10.47381702
106KDR0.46701426
107MAPKAPK30.45881824
108PRKDC0.44812559
109FGFR10.44343699
110BMX0.43588335
111AKT20.42288127
112TAOK20.42018548
113LATS10.40649360
114EIF2AK20.40555594
115PRKCG0.40051215
116CAMK1G0.38723763
117BRAF0.38263452
118KSR10.38256352
119SMG10.38027058
120DYRK20.36253036
121MAPK140.36039383
122PAK20.35570439
123MET0.35162397
124MAPKAPK50.34714447
125EPHA30.30885752
126ERBB40.29035457
127TEC0.28369894
128AKT10.28309294
129MARK30.28082105
130ADRBK20.27298468
131GSK3B0.27034482
132RPS6KC10.26720582
133RPS6KL10.26720582
134RPS6KA50.26665127
135CSNK1D0.26140202
136ILK0.25817104
137CLK10.24106709
138MAP2K30.23801102
139NEK90.22948032
140YES10.22891339
141RPS6KA60.22844709

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99985806
2Mismatch repair_Homo sapiens_hsa034304.35270545
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61872593
4Spliceosome_Homo sapiens_hsa030403.33742764
5* RNA transport_Homo sapiens_hsa030133.20574349
6Homologous recombination_Homo sapiens_hsa034403.06840383
7Base excision repair_Homo sapiens_hsa034103.01480824
8Cell cycle_Homo sapiens_hsa041102.99776454
9Nucleotide excision repair_Homo sapiens_hsa034202.96491781
10One carbon pool by folate_Homo sapiens_hsa006702.96244193
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.80136563
12RNA polymerase_Homo sapiens_hsa030202.79173187
13Proteasome_Homo sapiens_hsa030502.70083373
14Ribosome_Homo sapiens_hsa030102.45435830
15Fanconi anemia pathway_Homo sapiens_hsa034602.29590147
16Pyrimidine metabolism_Homo sapiens_hsa002402.12488542
17Non-homologous end-joining_Homo sapiens_hsa034502.05482370
18mRNA surveillance pathway_Homo sapiens_hsa030152.04904656
19RNA degradation_Homo sapiens_hsa030181.96662159
20Basal transcription factors_Homo sapiens_hsa030221.87793993
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74164964
22p53 signaling pathway_Homo sapiens_hsa041151.73942950
23Parkinsons disease_Homo sapiens_hsa050121.73784643
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68897851
25Oxidative phosphorylation_Homo sapiens_hsa001901.58506288
26Steroid biosynthesis_Homo sapiens_hsa001001.43087965
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31055563
28Epstein-Barr virus infection_Homo sapiens_hsa051691.30727981
29Oocyte meiosis_Homo sapiens_hsa041141.26447752
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23264732
31Propanoate metabolism_Homo sapiens_hsa006401.22605805
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13045590
33Purine metabolism_Homo sapiens_hsa002301.11222011
34Viral carcinogenesis_Homo sapiens_hsa052031.10014024
35Pyruvate metabolism_Homo sapiens_hsa006201.09089310
36Sulfur relay system_Homo sapiens_hsa041221.03611463
37Antigen processing and presentation_Homo sapiens_hsa046121.02244330
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00626573
39Fatty acid elongation_Homo sapiens_hsa000620.98438511
40HTLV-I infection_Homo sapiens_hsa051660.96698239
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94850575
42MicroRNAs in cancer_Homo sapiens_hsa052060.92976884
43Systemic lupus erythematosus_Homo sapiens_hsa053220.92275516
44Herpes simplex infection_Homo sapiens_hsa051680.92191189
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89123406
46Alzheimers disease_Homo sapiens_hsa050100.81947127
47Thyroid cancer_Homo sapiens_hsa052160.81217472
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78940084
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75013852
50Hippo signaling pathway_Homo sapiens_hsa043900.73645759
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71754221
52Small cell lung cancer_Homo sapiens_hsa052220.70853737
53Nicotine addiction_Homo sapiens_hsa050330.70338214
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70223816
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70012401
56Basal cell carcinoma_Homo sapiens_hsa052170.69872196
57TGF-beta signaling pathway_Homo sapiens_hsa043500.67204802
58Biosynthesis of amino acids_Homo sapiens_hsa012300.65721962
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63976866
60Colorectal cancer_Homo sapiens_hsa052100.62048572
61Bladder cancer_Homo sapiens_hsa052190.60427264
62Vitamin B6 metabolism_Homo sapiens_hsa007500.60219592
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59828742
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56235765
65Adherens junction_Homo sapiens_hsa045200.56069002
66Metabolic pathways_Homo sapiens_hsa011000.55857105
67Apoptosis_Homo sapiens_hsa042100.55272177
68Legionellosis_Homo sapiens_hsa051340.54499567
69Hedgehog signaling pathway_Homo sapiens_hsa043400.53909054
70Chronic myeloid leukemia_Homo sapiens_hsa052200.53898222
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53292180
72Notch signaling pathway_Homo sapiens_hsa043300.53286530
73HIF-1 signaling pathway_Homo sapiens_hsa040660.52110389
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49955613
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.49277863
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.49222528
77Viral myocarditis_Homo sapiens_hsa054160.48595998
78Pentose phosphate pathway_Homo sapiens_hsa000300.47670187
79Selenocompound metabolism_Homo sapiens_hsa004500.47053821
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44879860
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43705357
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.43644247
83Pathways in cancer_Homo sapiens_hsa052000.43113069
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42373033
85Hepatitis B_Homo sapiens_hsa051610.42134905
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41860303
87Alcoholism_Homo sapiens_hsa050340.40778408
88Glutathione metabolism_Homo sapiens_hsa004800.40273573
89Butanoate metabolism_Homo sapiens_hsa006500.39978634
90Shigellosis_Homo sapiens_hsa051310.39915262
91Fatty acid metabolism_Homo sapiens_hsa012120.39561283
92Cardiac muscle contraction_Homo sapiens_hsa042600.38991623
93mTOR signaling pathway_Homo sapiens_hsa041500.38919299
94N-Glycan biosynthesis_Homo sapiens_hsa005100.38618427
95Primary immunodeficiency_Homo sapiens_hsa053400.33805358
96Prostate cancer_Homo sapiens_hsa052150.31858359
97Melanoma_Homo sapiens_hsa052180.31759795
98Peroxisome_Homo sapiens_hsa041460.30742292
99Non-small cell lung cancer_Homo sapiens_hsa052230.30426351
100Proteoglycans in cancer_Homo sapiens_hsa052050.29834380
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28658805
102Acute myeloid leukemia_Homo sapiens_hsa052210.28103817
103Regulation of autophagy_Homo sapiens_hsa041400.28079451
104Tight junction_Homo sapiens_hsa045300.27835676
105Endometrial cancer_Homo sapiens_hsa052130.27679569
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27363216
107Measles_Homo sapiens_hsa051620.27250761
108Wnt signaling pathway_Homo sapiens_hsa043100.26235225
109Arginine and proline metabolism_Homo sapiens_hsa003300.26011232
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.25814153
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24333266
112Protein export_Homo sapiens_hsa030600.24119979
113Influenza A_Homo sapiens_hsa051640.23292435
114Phototransduction_Homo sapiens_hsa047440.23119881
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22545818
116Pancreatic cancer_Homo sapiens_hsa052120.21426749
117Taste transduction_Homo sapiens_hsa047420.20591400
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.19348714
119Lysine degradation_Homo sapiens_hsa003100.18908431
120Huntingtons disease_Homo sapiens_hsa050160.18622262
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17678518
122Carbon metabolism_Homo sapiens_hsa012000.17671880
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17473800
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17191885
125FoxO signaling pathway_Homo sapiens_hsa040680.16559968
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.16233098
127Fructose and mannose metabolism_Homo sapiens_hsa000510.14814346
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.14412604
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13843306
130Sulfur metabolism_Homo sapiens_hsa009200.12909416
131Galactose metabolism_Homo sapiens_hsa000520.12616191
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12138292
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12007561
134Renin-angiotensin system_Homo sapiens_hsa046140.11994527
135GABAergic synapse_Homo sapiens_hsa047270.10752019
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10530461
137Folate biosynthesis_Homo sapiens_hsa007900.10402238
138Olfactory transduction_Homo sapiens_hsa047400.10261614
139Synaptic vesicle cycle_Homo sapiens_hsa047210.05936774
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.04956225
141beta-Alanine metabolism_Homo sapiens_hsa004100.04928228
142Vibrio cholerae infection_Homo sapiens_hsa051100.03596239
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.02628404
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02556742

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