NUP62CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a domain found in nucleoporins which are glycoproteins found in nuclear pore complexes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.25735851
2regulation of posttranscriptional gene silencing (GO:0060147)5.20253815
3regulation of gene silencing by miRNA (GO:0060964)5.20253815
4regulation of gene silencing by RNA (GO:0060966)5.20253815
5nuclear pore complex assembly (GO:0051292)5.09727812
6piRNA metabolic process (GO:0034587)4.69003441
7purine nucleobase biosynthetic process (GO:0009113)4.63458830
8nucleobase biosynthetic process (GO:0046112)4.59060197
9DNA replication-dependent nucleosome organization (GO:0034723)4.54208022
10DNA replication-dependent nucleosome assembly (GO:0006335)4.54208022
11sister chromatid segregation (GO:0000819)4.51938224
12DNA ligation (GO:0006266)4.36616933
13DNA replication checkpoint (GO:0000076)4.32270829
14mitotic metaphase plate congression (GO:0007080)4.29702285
15proteasome assembly (GO:0043248)4.26359295
16DNA replication initiation (GO:0006270)4.23683314
17synaptonemal complex assembly (GO:0007130)4.20861809
18formation of translation preinitiation complex (GO:0001731)4.14115077
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.11430393
20mitotic recombination (GO:0006312)4.09041953
21microtubule depolymerization (GO:0007019)3.97155443
22DNA methylation involved in gamete generation (GO:0043046)3.96782753
23pore complex assembly (GO:0046931)3.93299407
24establishment of integrated proviral latency (GO:0075713)3.90531865
25mitotic nuclear envelope disassembly (GO:0007077)3.88418117
26ribosome assembly (GO:0042255)3.86698079
27synaptonemal complex organization (GO:0070193)3.84652154
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.80137033
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80137033
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.73416804
31protein K6-linked ubiquitination (GO:0085020)3.71888334
32metaphase plate congression (GO:0051310)3.67514779
33heterochromatin organization (GO:0070828)3.66933950
34protein localization to kinetochore (GO:0034501)3.66868790
35IMP biosynthetic process (GO:0006188)3.66560863
36DNA topological change (GO:0006265)3.65094030
37membrane disassembly (GO:0030397)3.64770985
38nuclear envelope disassembly (GO:0051081)3.64770985
39regulation of helicase activity (GO:0051095)3.64543982
40chromatin remodeling at centromere (GO:0031055)3.63999504
41histone H4-K12 acetylation (GO:0043983)3.60650640
42maturation of SSU-rRNA (GO:0030490)3.53376583
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52568499
44ribosome biogenesis (GO:0042254)3.49993299
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48507461
46DNA strand elongation involved in DNA replication (GO:0006271)3.47326660
47replication fork processing (GO:0031297)3.46792368
48centriole replication (GO:0007099)3.46219265
49DNA unwinding involved in DNA replication (GO:0006268)3.45895934
50regulation of meiosis I (GO:0060631)3.44410901
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42183099
52CENP-A containing nucleosome assembly (GO:0034080)3.38225075
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38098404
54folic acid-containing compound biosynthetic process (GO:0009396)3.35230932
55meiotic nuclear division (GO:0007126)3.34646945
56negative regulation of histone methylation (GO:0031061)3.32883568
57histone H2A monoubiquitination (GO:0035518)3.30390414
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28608289
59paraxial mesoderm development (GO:0048339)3.26999851
60DNA replication-independent nucleosome organization (GO:0034724)3.26941762
61DNA replication-independent nucleosome assembly (GO:0006336)3.26941762
62mitotic chromosome condensation (GO:0007076)3.26740675
63chromosome organization involved in meiosis (GO:0070192)3.26454932
64DNA strand elongation (GO:0022616)3.26288525
65telomere maintenance via telomere lengthening (GO:0010833)3.24699034
66blastocyst development (GO:0001824)3.21532172
67histone exchange (GO:0043486)3.20889513
68regulation of spindle organization (GO:0090224)3.19453646
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19247151
70attachment of spindle microtubules to kinetochore (GO:0008608)3.17900176
71kinetochore organization (GO:0051383)3.17018100
72mitotic sister chromatid segregation (GO:0000070)3.16518720
73regulation of histone H3-K9 methylation (GO:0051570)3.16041475
74regulation of double-strand break repair via homologous recombination (GO:0010569)3.15836956
75chromosome segregation (GO:0007059)3.13759504
76establishment of chromosome localization (GO:0051303)3.12638323
77positive regulation of chromosome segregation (GO:0051984)3.10074479
78IMP metabolic process (GO:0046040)3.10013453
79protein localization to chromosome (GO:0034502)3.09779614
80DNA geometric change (GO:0032392)3.07295106
81regulation of centrosome cycle (GO:0046605)3.06442739
82negative regulation of ligase activity (GO:0051352)3.06372100
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06372100
84regulation of telomere maintenance via telomerase (GO:0032210)3.05838952
85transcription-coupled nucleotide-excision repair (GO:0006283)3.05828976
86pre-miRNA processing (GO:0031054)3.05793393
87negative regulation of chromosome segregation (GO:0051985)3.04375187
88telomere maintenance via semi-conservative replication (GO:0032201)3.04030903
89kinetochore assembly (GO:0051382)3.03668782
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03411829
91ATP synthesis coupled proton transport (GO:0015986)3.03411829
92reciprocal meiotic recombination (GO:0007131)3.02402134
93reciprocal DNA recombination (GO:0035825)3.02402134
94male meiosis (GO:0007140)3.02292355
95regulation of mitochondrial translation (GO:0070129)3.01714638
96pseudouridine synthesis (GO:0001522)3.01015296
97regulation of translational termination (GO:0006449)3.00647429
98spindle checkpoint (GO:0031577)2.99911467
99DNA duplex unwinding (GO:0032508)2.98538021
100gene silencing by RNA (GO:0031047)2.98406401
101positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97169722
102non-recombinational repair (GO:0000726)2.96549418
103double-strand break repair via nonhomologous end joining (GO:0006303)2.96549418
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96415747
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96258929
106negative regulation of sister chromatid segregation (GO:0033046)2.96258929
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.96258929
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96258929
109meiotic cell cycle process (GO:1903046)2.96143140
110regulation of sister chromatid segregation (GO:0033045)2.95840738
111regulation of mitotic sister chromatid separation (GO:0010965)2.95840738
112regulation of mitotic sister chromatid segregation (GO:0033047)2.95840738
113ribonucleoprotein complex biogenesis (GO:0022613)2.95401089
114regulation of centriole replication (GO:0046599)2.94927198
115regulation of chromosome segregation (GO:0051983)2.94573707
116mitotic cell cycle (GO:0000278)2.94059426
117regulation of mitotic spindle organization (GO:0060236)2.94002208
118regulation of DNA endoreduplication (GO:0032875)2.93881586
119meiotic chromosome segregation (GO:0045132)2.93332878
120protein localization to chromosome, centromeric region (GO:0071459)2.92152526
121regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92136973
122mitotic spindle checkpoint (GO:0071174)2.91817618
123negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.91622347
124establishment of viral latency (GO:0019043)2.91378664
125mitotic spindle assembly checkpoint (GO:0007094)2.90659930
126chromosome condensation (GO:0030261)2.90310327
127trophectodermal cell differentiation (GO:0001829)2.90240157
128spindle assembly checkpoint (GO:0071173)2.89191193
129mitotic G2/M transition checkpoint (GO:0044818)2.89056061
130placenta development (GO:0001890)2.88901040
131protein neddylation (GO:0045116)2.87548927
132mRNA transport (GO:0051028)2.86810648
133cullin deneddylation (GO:0010388)2.86243439
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86039240
135intra-S DNA damage checkpoint (GO:0031573)2.85971502
136anterior/posterior axis specification, embryo (GO:0008595)2.85166346
137ventricular cardiac muscle cell development (GO:0055015)2.84745649
138resolution of meiotic recombination intermediates (GO:0000712)2.84687896
139regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84333621
140chromatin assembly or disassembly (GO:0006333)2.84222978
141ATP-dependent chromatin remodeling (GO:0043044)2.84095058
142regulation of gene silencing (GO:0060968)2.83712651
143chaperone-mediated protein complex assembly (GO:0051131)2.83684737
144telomere maintenance via recombination (GO:0000722)2.81792603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.39017605
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.15419254
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.39184707
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24649680
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16232204
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97156525
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97156525
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97156525
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.85051655
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79493862
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75020021
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71398661
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59349911
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51112794
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47048243
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45531689
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43970466
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39547356
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.38214918
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.37970776
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37386989
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32774827
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.31818708
24AR_21909140_ChIP-Seq_LNCAP_Human2.31350756
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29717336
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.23845438
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17085984
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.10503014
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.09334057
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08046018
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.07682281
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07466559
33STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04828369
34MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04440539
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02467325
36NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.01090922
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.98627552
38XRN2_22483619_ChIP-Seq_HELA_Human1.97734334
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.93331925
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90107016
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89657819
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81137965
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.79580289
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76317184
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.74031992
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70294345
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69978135
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69480203
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68007401
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64865482
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.60436559
52MYC_18940864_ChIP-ChIP_HL60_Human1.59746431
53DCP1A_22483619_ChIP-Seq_HELA_Human1.58281543
54VDR_23849224_ChIP-Seq_CD4+_Human1.57001870
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56945447
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56372958
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53844732
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47498616
59TTF2_22483619_ChIP-Seq_HELA_Human1.46643710
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46535266
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46516801
62GABP_19822575_ChIP-Seq_HepG2_Human1.46295470
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46247688
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45601707
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43827236
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43271287
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42546268
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42439226
69NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.41639862
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40101676
71EWS_26573619_Chip-Seq_HEK293_Human1.38889784
72FOXP3_21729870_ChIP-Seq_TREG_Human1.38540019
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37658292
74SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33497926
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33170850
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30868144
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.30428725
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.30211952
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26837000
80ELK1_19687146_ChIP-ChIP_HELA_Human1.25877128
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.25700127
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21534190
83FUS_26573619_Chip-Seq_HEK293_Human1.20975444
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20681296
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19071403
86KDM5A_27292631_Chip-Seq_BREAST_Human1.19019055
87SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17393793
88NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16560505
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13527497
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13520985
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11781223
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11386122
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10338973
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10047340
95TFEB_21752829_ChIP-Seq_HELA_Human1.09765944
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09417855
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08952592
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07506601
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05528726
100NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04952056
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04846654
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03594233
103SOX17_20123909_ChIP-Seq_XEN_Mouse1.03436737
104POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02334742
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98833833
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98687285
107KAP1_27257070_Chip-Seq_ESCs_Mouse0.98031523
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96328230
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95696286
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94480293
111NANOG_16518401_ChIP-PET_MESCs_Mouse0.94150658
112VDR_22108803_ChIP-Seq_LS180_Human0.91665027
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90123237
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.89937700
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88087723
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88035434
117IRF1_19129219_ChIP-ChIP_H3396_Human0.87491920
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.86205319
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85979685
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82484528
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77904696
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76245177
123CIITA_25753668_ChIP-Seq_RAJI_Human0.75665133
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74987085
125ZNF274_21170338_ChIP-Seq_K562_Hela0.74893095
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73374304
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.71337215
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70517006
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67949223
130ZNF263_19887448_ChIP-Seq_K562_Human0.65886551
131TAF15_26573619_Chip-Seq_HEK293_Human0.64325500
132TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.63221521
133CHD1_26751641_Chip-Seq_LNCaP_Human0.59928148
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.59467877
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.59202928
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.58766041
137TBX5_21415370_ChIP-Seq_HL-1_Mouse0.57533885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting4.27920505
2MP0004957_abnormal_blastocyst_morpholog4.12115164
3MP0003693_abnormal_embryo_hatching3.92642107
4MP0010094_abnormal_chromosome_stability3.67503532
5MP0008877_abnormal_DNA_methylation3.60161802
6MP0003111_abnormal_nucleus_morphology3.33996236
7MP0003077_abnormal_cell_cycle3.28367024
8MP0008057_abnormal_DNA_replication3.01305088
9MP0008058_abnormal_DNA_repair2.99098270
10MP0003121_genomic_imprinting2.64774781
11MP0004147_increased_porphyrin_level2.60013554
12MP0001730_embryonic_growth_arrest2.59885172
13MP0003806_abnormal_nucleotide_metabolis2.45653653
14MP0009697_abnormal_copulation2.40616471
15MP0008932_abnormal_embryonic_tissue2.33632855
16MP0004264_abnormal_extraembryonic_tissu2.31946728
17MP0010352_gastrointestinal_tract_polyps2.30982379
18MP0008007_abnormal_cellular_replicative2.25199455
19MP0004133_heterotaxia2.23599973
20MP0003786_premature_aging2.22201575
21MP0002938_white_spotting2.13871710
22MP0001672_abnormal_embryogenesis/_devel2.12443188
23MP0005380_embryogenesis_phenotype2.12443188
24MP0002084_abnormal_developmental_patter2.05490678
25MP0002086_abnormal_extraembryonic_tissu2.01591587
26MP0002210_abnormal_sex_determination2.01445075
27MP0004197_abnormal_fetal_growth/weight/1.98920180
28MP0000350_abnormal_cell_proliferation1.97252618
29MP0001697_abnormal_embryo_size1.95189229
30MP0003119_abnormal_digestive_system1.94902648
31MP0003984_embryonic_growth_retardation1.93282101
32MP0003705_abnormal_hypodermis_morpholog1.92906152
33MP0002088_abnormal_embryonic_growth/wei1.87737923
34MP0002085_abnormal_embryonic_tissue1.85903320
35MP0003567_abnormal_fetal_cardiomyocyte1.81069938
36MP0001145_abnormal_male_reproductive1.79463106
37MP0002653_abnormal_ependyma_morphology1.76275190
38MP0003890_abnormal_embryonic-extraembry1.75238594
39MP0003941_abnormal_skin_development1.71783987
40MP0003566_abnormal_cell_adhesion1.66789187
41MP0001529_abnormal_vocalization1.65083754
42MP0004272_abnormal_basement_membrane1.63870596
43MP0001929_abnormal_gametogenesis1.61006739
44MP0003718_maternal_effect1.60025048
45MP0002080_prenatal_lethality1.59971543
46MP0002102_abnormal_ear_morphology1.59698254
47MP0000653_abnormal_sex_gland1.51929607
48MP0010307_abnormal_tumor_latency1.51376364
49MP0006072_abnormal_retinal_apoptosis1.51373069
50MP0002160_abnormal_reproductive_system1.50576485
51MP0005623_abnormal_meninges_morphology1.44649081
52MP0006035_abnormal_mitochondrial_morpho1.44367039
53MP0001293_anophthalmia1.43843921
54MP0008995_early_reproductive_senescence1.39691858
55MP0005076_abnormal_cell_differentiation1.37124592
56MP0010030_abnormal_orbit_morphology1.36485574
57MP0000647_abnormal_sebaceous_gland1.34991900
58MP0006036_abnormal_mitochondrial_physio1.33601398
59MP0003122_maternal_imprinting1.32295391
60MP0008789_abnormal_olfactory_epithelium1.28825990
61MP0000566_synostosis1.26669798
62MP0000383_abnormal_hair_follicle1.22169582
63MP0001346_abnormal_lacrimal_gland1.21810326
64MP0002234_abnormal_pharynx_morphology1.18176500
65MP0010234_abnormal_vibrissa_follicle1.14750823
66MP0003787_abnormal_imprinting1.13329073
67MP0003698_abnormal_male_reproductive1.10358484
68MP0005367_renal/urinary_system_phenotyp1.06845231
69MP0000516_abnormal_urinary_system1.06845231
70MP0001915_intracranial_hemorrhage1.06337123
71MP0003315_abnormal_perineum_morphology1.06115326
72MP0003283_abnormal_digestive_organ1.05852761
73MP0006292_abnormal_olfactory_placode1.04559200
74MP0005266_abnormal_metabolism1.04214879
75MP0010678_abnormal_skin_adnexa1.01528712
76MP0000313_abnormal_cell_death1.01301759
77MP0003136_yellow_coat_color1.01247071
78MP0003937_abnormal_limbs/digits/tail_de1.00438576
79MP0005023_abnormal_wound_healing0.99297081
80MP0005389_reproductive_system_phenotype0.98824045
81MP0000537_abnormal_urethra_morphology0.98161866
82MP0009053_abnormal_anal_canal0.97401047
83MP0009672_abnormal_birth_weight0.95519786
84MP0001727_abnormal_embryo_implantation0.95087422
85MP0002111_abnormal_tail_morphology0.93839833
86MP0005394_taste/olfaction_phenotype0.92757452
87MP0005499_abnormal_olfactory_system0.92757452
88MP0009703_decreased_birth_body0.91510715
89MP0005253_abnormal_eye_physiology0.91270385
90MP0005391_vision/eye_phenotype0.89154337
91MP0005187_abnormal_penis_morphology0.87434537
92MP0001849_ear_inflammation0.87366215
93MP0003656_abnormal_erythrocyte_physiolo0.86560259
94MP0000631_abnormal_neuroendocrine_gland0.86073888
95MP0002697_abnormal_eye_size0.86070763
96MP0003936_abnormal_reproductive_system0.85461573
97MP0002127_abnormal_cardiovascular_syste0.85353660
98MP0001119_abnormal_female_reproductive0.85020136
99MP0002233_abnormal_nose_morphology0.83972850
100MP0002161_abnormal_fertility/fecundity0.83187105
101MP0002019_abnormal_tumor_incidence0.81906121
102MP0004084_abnormal_cardiac_muscle0.81751060
103MP0005384_cellular_phenotype0.81686625
104MP0003221_abnormal_cardiomyocyte_apopto0.80996922
105MP0001286_abnormal_eye_development0.80773006
106MP0001764_abnormal_homeostasis0.80298398
107MP0000579_abnormal_nail_morphology0.79041181
108MP0002132_abnormal_respiratory_system0.78751151
109MP0002282_abnormal_trachea_morphology0.78233132
110MP0002269_muscular_atrophy0.76756155
111MP0003186_abnormal_redox_activity0.75876320
112MP0000049_abnormal_middle_ear0.75818349
113MP0002009_preneoplasia0.75098297
114MP0003861_abnormal_nervous_system0.74889388
115MP0005395_other_phenotype0.74015017
116MP0005621_abnormal_cell_physiology0.71958728
117MP0003195_calcinosis0.71809583
118MP0003646_muscle_fatigue0.70585574
119MP0000432_abnormal_head_morphology0.69693141
120MP0002925_abnormal_cardiovascular_devel0.68462990
121MP0000428_abnormal_craniofacial_morphol0.67382576
122MP0003755_abnormal_palate_morphology0.66448570
123MP0004185_abnormal_adipocyte_glucose0.65738286
124MP0003699_abnormal_female_reproductive0.64511333
125MP0000490_abnormal_crypts_of0.64298416
126MP0005377_hearing/vestibular/ear_phenot0.63305738
127MP0003878_abnormal_ear_physiology0.63305738
128MP0002796_impaired_skin_barrier0.63230393
129MP0000358_abnormal_cell_content/0.62343695
130MP0002092_abnormal_eye_morphology0.62262516
131MP0001661_extended_life_span0.62098057
132MP0001881_abnormal_mammary_gland0.61256316
133MP0005501_abnormal_skin_physiology0.61068745
134MP0003943_abnormal_hepatobiliary_system0.60864120
135MP0005647_abnormal_sex_gland0.60855097
136MP0004233_abnormal_muscle_weight0.60470958
137MP0006054_spinal_hemorrhage0.60248979
138MP0005075_abnormal_melanosome_morpholog0.59457650
139MP0003942_abnormal_urinary_system0.54728995

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.66315658
2Ependymoma (HP:0002888)4.62858959
3Breast hypoplasia (HP:0003187)4.37240202
4Selective tooth agenesis (HP:0001592)4.29593021
5Abnormality of the labia minora (HP:0012880)3.92043902
6Absent radius (HP:0003974)3.64147792
7Supernumerary spleens (HP:0009799)3.53231403
8Colon cancer (HP:0003003)3.48094456
9Carpal bone hypoplasia (HP:0001498)3.45883325
10Aplasia involving forearm bones (HP:0009822)3.40761572
11Absent forearm bone (HP:0003953)3.40761572
12Medulloblastoma (HP:0002885)3.29332218
13Missing ribs (HP:0000921)3.19603063
14Impulsivity (HP:0100710)3.17913333
15Aplasia/hypoplasia of the humerus (HP:0006507)3.15144833
16Acute necrotizing encephalopathy (HP:0006965)3.13984773
17Abnormality of the astrocytes (HP:0100707)3.10616782
18Astrocytoma (HP:0009592)3.10616782
19Abnormal mitochondria in muscle tissue (HP:0008316)3.05974992
20Shawl scrotum (HP:0000049)3.05869590
21Oral leukoplakia (HP:0002745)2.98320638
22Acute encephalopathy (HP:0006846)2.98004183
23Rhabdomyosarcoma (HP:0002859)2.96292598
24Patellar aplasia (HP:0006443)2.95704459
25Agnosia (HP:0010524)2.93522620
26Abnormality of the anterior horn cell (HP:0006802)2.92505033
27Degeneration of anterior horn cells (HP:0002398)2.92505033
28Short humerus (HP:0005792)2.90812966
29Chromsome breakage (HP:0040012)2.90259330
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76871274
31Stenosis of the external auditory canal (HP:0000402)2.76048682
32Increased serum pyruvate (HP:0003542)2.75424166
33Aplasia/Hypoplasia of the patella (HP:0006498)2.74960543
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74385396
35Neoplasm of the oral cavity (HP:0100649)2.74001008
36Increased CSF lactate (HP:0002490)2.68184898
37Glioma (HP:0009733)2.67170765
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65080851
39Absent thumb (HP:0009777)2.60489856
40Abnormality of glycolysis (HP:0004366)2.59433050
41Abnormal respiratory motile cilium physiology (HP:0012261)2.59430669
42Meckel diverticulum (HP:0002245)2.59140332
43Mitochondrial inheritance (HP:0001427)2.58289729
44Deviation of the thumb (HP:0009603)2.55055011
45Pancreatic cysts (HP:0001737)2.55022823
46Abnormality of abdominal situs (HP:0011620)2.54128088
47Abdominal situs inversus (HP:0003363)2.54128088
4811 pairs of ribs (HP:0000878)2.52094084
49Progressive macrocephaly (HP:0004481)2.51883174
50Abnormal ciliary motility (HP:0012262)2.47282190
51True hermaphroditism (HP:0010459)2.45889182
52Increased hepatocellular lipid droplets (HP:0006565)2.45160619
53Pancreatic fibrosis (HP:0100732)2.44712106
54Proximal placement of thumb (HP:0009623)2.42790583
55Abnormality of the ileum (HP:0001549)2.40962743
56Hepatocellular necrosis (HP:0001404)2.40499235
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.40132462
58Biliary tract neoplasm (HP:0100574)2.37362102
59Cerebral edema (HP:0002181)2.37275439
60Hepatic necrosis (HP:0002605)2.37059622
61Abnormal spermatogenesis (HP:0008669)2.36592606
62Volvulus (HP:0002580)2.36162496
63Rectal fistula (HP:0100590)2.35621066
64Rectovaginal fistula (HP:0000143)2.35621066
65Abnormality of chromosome stability (HP:0003220)2.35291249
66Abnormality of the lower motor neuron (HP:0002366)2.33853315
67Azoospermia (HP:0000027)2.33256741
68Myelodysplasia (HP:0002863)2.32654299
69Medial flaring of the eyebrow (HP:0010747)2.31734908
70Horseshoe kidney (HP:0000085)2.31161528
71Neoplasm of striated muscle (HP:0009728)2.30130364
72Trismus (HP:0000211)2.28907642
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28533375
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28533375
75Sloping forehead (HP:0000340)2.28127439
76Muscle fibrillation (HP:0010546)2.27200023
77Abnormal number of incisors (HP:0011064)2.26960641
78Abnormal respiratory epithelium morphology (HP:0012253)2.26708768
79Abnormal respiratory motile cilium morphology (HP:0005938)2.26708768
80Triphalangeal thumb (HP:0001199)2.26312770
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.25570336
82Type I transferrin isoform profile (HP:0003642)2.24913417
83Fused cervical vertebrae (HP:0002949)2.23651015
84Congenital primary aphakia (HP:0007707)2.23637744
85Rhinitis (HP:0012384)2.23563279
86Metaphyseal cupping (HP:0003021)2.22962696
87Abnormality of the carotid arteries (HP:0005344)2.22348219
88Facial cleft (HP:0002006)2.21904895
89Lipid accumulation in hepatocytes (HP:0006561)2.21845543
90Nephroblastoma (Wilms tumor) (HP:0002667)2.19200456
91Increased serum lactate (HP:0002151)2.16773840
92Cerebral hypomyelination (HP:0006808)2.16521693
93Multiple enchondromatosis (HP:0005701)2.16484332
943-Methylglutaconic aciduria (HP:0003535)2.16476283
95Esophageal atresia (HP:0002032)2.16452082
96Duodenal stenosis (HP:0100867)2.16354971
97Small intestinal stenosis (HP:0012848)2.16354971
98Duplicated collecting system (HP:0000081)2.16172143
99Embryonal renal neoplasm (HP:0011794)2.16171855
100Macrocytic anemia (HP:0001972)2.15865244
101Ectopic kidney (HP:0000086)2.15539432
102Abnormal lung lobation (HP:0002101)2.14520165
103Rib fusion (HP:0000902)2.14423101
104Delayed puberty (HP:0000823)2.14048889
105Abnormality of the preputium (HP:0100587)2.13386223
106Atrophy/Degeneration involving motor neurons (HP:0007373)2.12365656
107Abnormality of the salivary glands (HP:0010286)2.10008704
108Tubulointerstitial nephritis (HP:0001970)2.08833130
109Tongue fasciculations (HP:0001308)2.07537199
110Postaxial foot polydactyly (HP:0001830)2.07527340
111Premature ovarian failure (HP:0008209)2.06478423
112Basal cell carcinoma (HP:0002671)2.05502510
113Facial hemangioma (HP:0000329)2.04083780
114Broad distal phalanx of finger (HP:0009836)2.03022943
115Neoplasm of the pancreas (HP:0002894)2.02154157
116Rough bone trabeculation (HP:0100670)2.01573027
117Sclerocornea (HP:0000647)2.01520771
118Abnormal biliary tract morphology (HP:0012440)2.00973795
119Gait imbalance (HP:0002141)2.00179259
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.99864853
121Absent/shortened dynein arms (HP:0200106)1.99864853
122Nephronophthisis (HP:0000090)1.99734341
123Anal stenosis (HP:0002025)1.98269104
124Ovarian neoplasm (HP:0100615)1.98114860
125Abnormality of methionine metabolism (HP:0010901)1.97741320
126Abnormality of midbrain morphology (HP:0002418)1.96894296
127Molar tooth sign on MRI (HP:0002419)1.96894296
128Nephrogenic diabetes insipidus (HP:0009806)1.95007975
129Reticulocytopenia (HP:0001896)1.93731408
130Abnormality of the duodenum (HP:0002246)1.93680644
131Atresia of the external auditory canal (HP:0000413)1.92540146
132Vaginal fistula (HP:0004320)1.91691881
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90981194
134Occipital encephalocele (HP:0002085)1.90154606
135High anterior hairline (HP:0009890)1.89688881
136Clubbing of toes (HP:0100760)1.88650226
137Squamous cell carcinoma (HP:0002860)1.88144006
138Intestinal fistula (HP:0100819)1.87575990
139Lactic acidosis (HP:0003128)1.86921503
140Vertebral clefting (HP:0008428)1.86356167
141Abnormal protein glycosylation (HP:0012346)1.85197491
142Abnormal glycosylation (HP:0012345)1.85197491
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85197491
144Abnormal protein N-linked glycosylation (HP:0012347)1.85197491
145Increased nuchal translucency (HP:0010880)1.85112318
146Abnormality of the renal collecting system (HP:0004742)1.84330967
147Exercise intolerance (HP:0003546)1.83924600
148Hypoplastic pelvis (HP:0008839)1.83831082
149Breast aplasia (HP:0100783)1.83038075
150Abnormality of pyrimidine metabolism (HP:0004353)1.82364845
151Tracheoesophageal fistula (HP:0002575)1.81763831
152Spinal muscular atrophy (HP:0007269)1.81051273
153Megaloblastic anemia (HP:0001889)1.80580395
154Renal cortical cysts (HP:0000803)1.79427700
155Abnormal number of erythroid precursors (HP:0012131)1.78936803
156Abnormality of cochlea (HP:0000375)1.77771434
157Aplasia/Hypoplasia of the spleen (HP:0010451)1.77706810
158Transposition of the great arteries (HP:0001669)1.76095771
159Abnormal connection of the cardiac segments (HP:0011545)1.76095771
160Abnormal ventriculo-arterial connection (HP:0011563)1.76095771
161Microvesicular hepatic steatosis (HP:0001414)1.75136242
162Cortical dysplasia (HP:0002539)1.74182889
163Abnormality of the fetal cardiovascular system (HP:0010948)1.74077393
164Single umbilical artery (HP:0001195)1.74077393
165Abnormality of cells of the erythroid lineage (HP:0012130)1.73735513
166Abnormality of reticulocytes (HP:0004312)1.73577606
167Hyperglycinemia (HP:0002154)1.73185361
168Abnormality of serum amino acid levels (HP:0003112)1.72438368
169Respiratory failure (HP:0002878)1.71541537
170Preaxial hand polydactyly (HP:0001177)1.71454492
171Oculomotor apraxia (HP:0000657)1.69707265
172Aplasia/hypoplasia of the uterus (HP:0008684)1.69687524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.38101070
2ACVR1B4.27706211
3CDC73.83017457
4PLK43.73565742
5NEK13.37357936
6BUB13.19385692
7CDK123.03566486
8VRK22.91142867
9TTK2.65414926
10RPS6KB22.36603357
11EPHA22.23366755
12PNCK2.11790007
13TSSK62.06049385
14PLK12.05305448
15NEK21.99097729
16STK38L1.98809626
17EIF2AK11.84624481
18PLK31.84454276
19SRPK11.81959728
20CCNB11.65683318
21NME11.61237040
22LATS21.60567208
23SCYL21.56788374
24EIF2AK31.54044315
25TAOK31.52962094
26CDK71.51809604
27AKT31.51102345
28BMPR1B1.50476692
29STK161.40381755
30CHEK11.40130728
31BRSK21.39421013
32CHEK21.38698186
33MST1R1.36393073
34AURKB1.35368434
35PASK1.33861351
36TAF11.29281208
37ATR1.21997075
38BRD41.18466723
39PAK41.16771060
40EIF2AK21.16242259
41MAP3K81.15614691
42PDK31.15466354
43PDK41.15466354
44AURKA1.13447440
45PRKCI1.06096112
46NUAK11.03413217
47MAPKAPK31.02589682
48ALK1.02133733
49MELK1.01376538
50MAP4K21.00508581
51CDK40.99846279
52BRSK10.96460749
53ATM0.96325128
54TRIM280.94435434
55PRKD30.94174005
56TESK10.93670458
57MET0.92609083
58STK100.91594216
59PKN20.90940202
60PBK0.89460830
61TESK20.89190668
62MKNK10.88041657
63ERBB30.87860895
64PDK20.86900724
65CDK20.86805910
66TAOK20.85949317
67BRAF0.84557203
68TGFBR10.83106850
69KSR10.80223849
70DYRK30.78956469
71ZAK0.77939736
72TNIK0.77332193
73LIMK10.77322256
74NME20.75016799
75MARK30.72667713
76LATS10.70750073
77DYRK20.68691320
78PIM10.68379622
79MKNK20.67503274
80MAP3K40.67376510
81ARAF0.66997177
82MAP3K90.66612331
83TYRO30.66565979
84BCR0.66491307
85VRK10.66133534
86MTOR0.64407927
87CDK10.64094305
88EPHB20.63364032
89CSNK2A20.62673353
90CDK30.62595135
91PAK10.61406206
92CSNK1E0.60283678
93STK30.58288397
94BCKDK0.57244083
95CDK80.56803902
96STK40.56609809
97MST40.55599100
98AKT20.55185863
99TLK10.55164989
100FLT30.54195230
101CSNK2A10.50675316
102WNK30.49331679
103MAP3K30.48377481
104PDGFRA0.47798391
105BMX0.46414675
106CDK60.44437950
107CSNK1D0.43771747
108FGFR10.43510347
109PKN10.41859343
110ICK0.41008513
111RPS6KA40.39636980
112FER0.38637837
113RPS6KA50.37825623
114PRKDC0.37799469
115MAP2K70.37546499
116CSNK1G10.37305993
117MAP2K30.37016055
118ERBB20.36329874
119KSR20.35692236
120PLK20.35633359
121CSNK1G30.34991707
122NEK90.34109633
123CSNK1A1L0.33943355
124EEF2K0.33823584
125RAF10.32319604
126MINK10.32101776
127STK240.30601020
128WNK40.30157887
129CLK10.29941217
130PAK20.29046461
131ERBB40.28316782
132MAPK140.25773876
133STK390.25053368
134CDK180.23513711
135MAPK130.23170534
136CDK11A0.20814372
137CDK150.19796327

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.58772756
2Mismatch repair_Homo sapiens_hsa034304.16116671
3DNA replication_Homo sapiens_hsa030304.07982180
4RNA transport_Homo sapiens_hsa030133.58409170
5Proteasome_Homo sapiens_hsa030503.21295670
6RNA polymerase_Homo sapiens_hsa030202.98104393
7One carbon pool by folate_Homo sapiens_hsa006702.94788685
8Spliceosome_Homo sapiens_hsa030402.93104121
9Nucleotide excision repair_Homo sapiens_hsa034202.85050072
10Cell cycle_Homo sapiens_hsa041102.76419119
11Homologous recombination_Homo sapiens_hsa034402.74960491
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73613249
13Basal transcription factors_Homo sapiens_hsa030222.66462540
14Base excision repair_Homo sapiens_hsa034102.31007232
15Oxidative phosphorylation_Homo sapiens_hsa001902.29108163
16Fanconi anemia pathway_Homo sapiens_hsa034602.18675020
17Parkinsons disease_Homo sapiens_hsa050122.09926209
18Protein export_Homo sapiens_hsa030602.07288692
19Non-homologous end-joining_Homo sapiens_hsa034502.06838287
20Ribosome_Homo sapiens_hsa030102.05662610
21mRNA surveillance pathway_Homo sapiens_hsa030152.03163491
22RNA degradation_Homo sapiens_hsa030181.97183086
23Pyrimidine metabolism_Homo sapiens_hsa002401.89178906
24p53 signaling pathway_Homo sapiens_hsa041151.70390131
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61552406
26Propanoate metabolism_Homo sapiens_hsa006401.47497398
27Biosynthesis of amino acids_Homo sapiens_hsa012301.45616378
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37038657
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25025615
30Fatty acid elongation_Homo sapiens_hsa000621.24856347
31Oocyte meiosis_Homo sapiens_hsa041141.22343834
32Alzheimers disease_Homo sapiens_hsa050101.22042010
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17339172
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13788803
35Hippo signaling pathway_Homo sapiens_hsa043901.12184394
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07704281
37Epstein-Barr virus infection_Homo sapiens_hsa051691.07469651
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.06517839
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05953371
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05794220
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.02879331
42Purine metabolism_Homo sapiens_hsa002301.02065506
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99746923
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99158298
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98610527
46Selenocompound metabolism_Homo sapiens_hsa004500.98450376
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95401634
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94631938
49Folate biosynthesis_Homo sapiens_hsa007900.92879699
50TGF-beta signaling pathway_Homo sapiens_hsa043500.89802576
51Butanoate metabolism_Homo sapiens_hsa006500.86957311
52Linoleic acid metabolism_Homo sapiens_hsa005910.85160104
53Carbon metabolism_Homo sapiens_hsa012000.85139390
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82894409
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82546149
56Thyroid cancer_Homo sapiens_hsa052160.80701090
57Steroid biosynthesis_Homo sapiens_hsa001000.80021679
58Tight junction_Homo sapiens_hsa045300.78239874
59Small cell lung cancer_Homo sapiens_hsa052220.77387822
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76611522
61Viral carcinogenesis_Homo sapiens_hsa052030.75310346
62Pentose phosphate pathway_Homo sapiens_hsa000300.72533808
63Fructose and mannose metabolism_Homo sapiens_hsa000510.71911998
64Glutathione metabolism_Homo sapiens_hsa004800.69848173
65Basal cell carcinoma_Homo sapiens_hsa052170.68405902
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68326147
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.67094323
68Galactose metabolism_Homo sapiens_hsa000520.65213529
69MicroRNAs in cancer_Homo sapiens_hsa052060.63885722
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62631695
71Adherens junction_Homo sapiens_hsa045200.62118726
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59846135
73Systemic lupus erythematosus_Homo sapiens_hsa053220.59146867
74Hedgehog signaling pathway_Homo sapiens_hsa043400.55848722
75HTLV-I infection_Homo sapiens_hsa051660.54048446
76Phototransduction_Homo sapiens_hsa047440.52461591
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51699659
78Fatty acid metabolism_Homo sapiens_hsa012120.51053513
79Antigen processing and presentation_Homo sapiens_hsa046120.50377898
80Herpes simplex infection_Homo sapiens_hsa051680.49735773
81Huntingtons disease_Homo sapiens_hsa050160.49573719
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.47892911
83Peroxisome_Homo sapiens_hsa041460.47455357
84Fat digestion and absorption_Homo sapiens_hsa049750.46762764
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46042827
86N-Glycan biosynthesis_Homo sapiens_hsa005100.44310583
87Arginine and proline metabolism_Homo sapiens_hsa003300.44300043
88Vitamin digestion and absorption_Homo sapiens_hsa049770.43245634
89Arachidonic acid metabolism_Homo sapiens_hsa005900.43014818
90Cardiac muscle contraction_Homo sapiens_hsa042600.41590991
91HIF-1 signaling pathway_Homo sapiens_hsa040660.40753947
92Vitamin B6 metabolism_Homo sapiens_hsa007500.40392424
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39859876
94Lysine degradation_Homo sapiens_hsa003100.36348351
95Pathways in cancer_Homo sapiens_hsa052000.35541916
96mTOR signaling pathway_Homo sapiens_hsa041500.35453472
97Tyrosine metabolism_Homo sapiens_hsa003500.34098747
98Sulfur metabolism_Homo sapiens_hsa009200.34010354
99Fatty acid degradation_Homo sapiens_hsa000710.33826807
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33825352
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33563342
102Bladder cancer_Homo sapiens_hsa052190.29820703
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29652150
104Sulfur relay system_Homo sapiens_hsa041220.28695403
105Regulation of autophagy_Homo sapiens_hsa041400.27605506
106beta-Alanine metabolism_Homo sapiens_hsa004100.27498347
107Fatty acid biosynthesis_Homo sapiens_hsa000610.27092141
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24859049
109Colorectal cancer_Homo sapiens_hsa052100.24608053
110Pyruvate metabolism_Homo sapiens_hsa006200.23552916
111Notch signaling pathway_Homo sapiens_hsa043300.22973180
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22866945
113Prostate cancer_Homo sapiens_hsa052150.19357307
114ECM-receptor interaction_Homo sapiens_hsa045120.19259750
115Metabolic pathways_Homo sapiens_hsa011000.19013247
116Renin-angiotensin system_Homo sapiens_hsa046140.18889723
117Olfactory transduction_Homo sapiens_hsa047400.18879508
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15769310
119Tryptophan metabolism_Homo sapiens_hsa003800.15621795
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.15340197
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15222275
122Arginine biosynthesis_Homo sapiens_hsa002200.15118345
123Wnt signaling pathway_Homo sapiens_hsa043100.14940701
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.13942684
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13705575
126Proteoglycans in cancer_Homo sapiens_hsa052050.12797553
127Collecting duct acid secretion_Homo sapiens_hsa049660.12527341
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12044764
129Legionellosis_Homo sapiens_hsa051340.09332306
130Nitrogen metabolism_Homo sapiens_hsa009100.09192715
131Ether lipid metabolism_Homo sapiens_hsa005650.09031639
132Focal adhesion_Homo sapiens_hsa045100.08848787
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07584862
134Alcoholism_Homo sapiens_hsa050340.07127752
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.05847980
136Renal cell carcinoma_Homo sapiens_hsa052110.05450427
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.05187117

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