NUP54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.45497144
2DNA replication initiation (GO:0006270)4.41319317
3mitotic metaphase plate congression (GO:0007080)4.40230394
4DNA double-strand break processing (GO:0000729)4.40110108
5DNA strand elongation (GO:0022616)4.36315693
6protein localization to kinetochore (GO:0034501)4.35115494
7telomere maintenance via semi-conservative replication (GO:0032201)4.22175222
8DNA unwinding involved in DNA replication (GO:0006268)4.16257706
9nuclear pore organization (GO:0006999)4.15798911
10proteasome assembly (GO:0043248)4.15288349
11CENP-A containing nucleosome assembly (GO:0034080)4.13847708
12DNA replication checkpoint (GO:0000076)4.11313536
13chromatin remodeling at centromere (GO:0031055)4.07420157
14maturation of SSU-rRNA (GO:0030490)4.07104510
15mitotic sister chromatid cohesion (GO:0007064)4.00899387
16telomere maintenance via recombination (GO:0000722)3.97538142
17* mitotic nuclear envelope disassembly (GO:0007077)3.94718938
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.94388344
19regulation of mitotic spindle checkpoint (GO:1903504)3.94388344
20nuclear pore complex assembly (GO:0051292)3.92440150
21folic acid-containing compound biosynthetic process (GO:0009396)3.90879656
22DNA replication-dependent nucleosome organization (GO:0034723)3.85752278
23DNA replication-dependent nucleosome assembly (GO:0006335)3.85752278
24metaphase plate congression (GO:0051310)3.85125936
25nucleobase biosynthetic process (GO:0046112)3.83594475
26DNA replication-independent nucleosome organization (GO:0034724)3.81004844
27DNA replication-independent nucleosome assembly (GO:0006336)3.81004844
28mitotic recombination (GO:0006312)3.76214015
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.74529624
30attachment of spindle microtubules to kinetochore (GO:0008608)3.69496872
31kinetochore organization (GO:0051383)3.67425366
32ribosome assembly (GO:0042255)3.65337454
33telomere maintenance via telomere lengthening (GO:0010833)3.63605590
34formation of translation preinitiation complex (GO:0001731)3.63454995
35* nuclear envelope disassembly (GO:0051081)3.62504138
36* membrane disassembly (GO:0030397)3.62504138
37IMP biosynthetic process (GO:0006188)3.60230374
38ribosomal small subunit assembly (GO:0000028)3.60226991
39DNA ligation (GO:0006266)3.58930665
40purine nucleobase biosynthetic process (GO:0009113)3.58840033
41protein localization to chromosome, centromeric region (GO:0071459)3.57897771
42non-recombinational repair (GO:0000726)3.56697616
43double-strand break repair via nonhomologous end joining (GO:0006303)3.56697616
44regulation of mitotic sister chromatid separation (GO:0010965)3.51384667
45regulation of mitotic sister chromatid segregation (GO:0033047)3.51384667
46regulation of sister chromatid segregation (GO:0033045)3.51384667
47DNA catabolic process, exonucleolytic (GO:0000738)3.50130311
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.46460132
49regulation of DNA endoreduplication (GO:0032875)3.44821086
50mitotic G2/M transition checkpoint (GO:0044818)3.41192555
51histone exchange (GO:0043486)3.40254076
52regulation of spindle organization (GO:0090224)3.38817296
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38708723
54ribosome biogenesis (GO:0042254)3.37547220
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37502070
56establishment of viral latency (GO:0019043)3.37172302
57establishment of chromosome localization (GO:0051303)3.36152522
58kinetochore assembly (GO:0051382)3.30141201
59IMP metabolic process (GO:0046040)3.29030645
60protein K6-linked ubiquitination (GO:0085020)3.28673249
61mitotic chromosome condensation (GO:0007076)3.27039758
62histone mRNA metabolic process (GO:0008334)3.24269646
63spliceosomal snRNP assembly (GO:0000387)3.23371661
64mitotic sister chromatid segregation (GO:0000070)3.22019137
65ribonucleoprotein complex biogenesis (GO:0022613)3.19362705
66replication fork processing (GO:0031297)3.19253591
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15183364
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14184320
69negative regulation of DNA recombination (GO:0045910)3.13051649
70DNA damage response, detection of DNA damage (GO:0042769)3.12544217
71ribosomal large subunit biogenesis (GO:0042273)3.12129040
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.10864903
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10864903
74pore complex assembly (GO:0046931)3.10602913
75spindle checkpoint (GO:0031577)3.10166934
76negative regulation of mitosis (GO:0045839)3.10126754
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09848296
78negative regulation of ligase activity (GO:0051352)3.09848296
79rRNA processing (GO:0006364)3.09291550
80cullin deneddylation (GO:0010388)3.08701409
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.07464163
82regulation of centriole replication (GO:0046599)3.06255283
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04778106
84DNA duplex unwinding (GO:0032508)3.04527704
85mismatch repair (GO:0006298)3.04465933
86synapsis (GO:0007129)3.02746879
87DNA geometric change (GO:0032392)3.02478265
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.01436011
89maturation of 5.8S rRNA (GO:0000460)3.01328252
90negative regulation of chromosome segregation (GO:0051985)3.01254976
91regulation of centrosome cycle (GO:0046605)3.01053193
92negative regulation of sister chromatid segregation (GO:0033046)3.00206670
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.00206670
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00206670
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00206670
96meiotic chromosome segregation (GO:0045132)2.99920457
97sister chromatid segregation (GO:0000819)2.99475074
98postreplication repair (GO:0006301)2.98649699
99chromatin assembly or disassembly (GO:0006333)2.98015173
100telomere maintenance (GO:0000723)2.97908090
101rRNA metabolic process (GO:0016072)2.97820318
102spindle assembly checkpoint (GO:0071173)2.97713323
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97712677
104DNA topological change (GO:0006265)2.97546669
105mitotic spindle checkpoint (GO:0071174)2.96352512
106telomere organization (GO:0032200)2.96074638
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95205747
108L-serine metabolic process (GO:0006563)2.95133277
109telomere maintenance via telomerase (GO:0007004)2.94329862
110RNA-dependent DNA replication (GO:0006278)2.94287253
111mitotic spindle assembly checkpoint (GO:0007094)2.94066053
112positive regulation of chromosome segregation (GO:0051984)2.93341441
113transcription-coupled nucleotide-excision repair (GO:0006283)2.92713166
114establishment of integrated proviral latency (GO:0075713)2.92301684
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89401766
116protein localization to chromosome (GO:0034502)2.88963399
117ribosomal small subunit biogenesis (GO:0042274)2.88738063
118regulation of mitotic spindle organization (GO:0060236)2.88567555
119regulation of helicase activity (GO:0051095)2.88463295
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87720155
121regulation of chromosome segregation (GO:0051983)2.86017937
122rRNA modification (GO:0000154)2.83452137
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81696654
124pseudouridine synthesis (GO:0001522)2.80733705
125spliceosomal complex assembly (GO:0000245)2.79460589
126termination of RNA polymerase I transcription (GO:0006363)2.79244701
127chromosome segregation (GO:0007059)2.78100208
128ATP-dependent chromatin remodeling (GO:0043044)2.77111738
129regulation of histone H3-K9 methylation (GO:0051570)2.77008562
130translational termination (GO:0006415)2.76917349
131viral transcription (GO:0019083)2.73569862
132cell cycle G1/S phase transition (GO:0044843)2.73311474
133G1/S transition of mitotic cell cycle (GO:0000082)2.73311474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.20500729
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.18933029
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.11697300
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97314156
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25622984
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23151318
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19641014
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.98807958
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90922205
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87738180
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.78075748
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67160200
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.56404522
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54260915
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48671139
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42063412
17* AR_21909140_ChIP-Seq_LNCAP_Human2.26134302
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24378947
19* VDR_23849224_ChIP-Seq_CD4+_Human2.21260338
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17247073
21XRN2_22483619_ChIP-Seq_HELA_Human2.16124250
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11976183
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08909618
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.08718043
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06201574
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01069959
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00350300
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99197812
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.96031257
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92573418
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.87065031
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.83018472
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81745376
34EWS_26573619_Chip-Seq_HEK293_Human1.80929438
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79841534
36TTF2_22483619_ChIP-Seq_HELA_Human1.76172206
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75515181
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.75293656
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74192018
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72956306
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69077062
42* GABP_19822575_ChIP-Seq_HepG2_Human1.68080429
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64237251
44FUS_26573619_Chip-Seq_HEK293_Human1.60738798
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60107640
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60100214
47CIITA_25753668_ChIP-Seq_RAJI_Human1.59409743
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55218741
49* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52570287
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49358994
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48880784
52* NANOG_16153702_ChIP-ChIP_HESCs_Human1.46389395
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45044024
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.44563087
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44448788
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41275666
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40548134
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.39521449
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39453189
60ZNF274_21170338_ChIP-Seq_K562_Hela1.38916413
61KDM5A_27292631_Chip-Seq_BREAST_Human1.37604434
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.36847511
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36190263
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33193385
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.32936005
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30834647
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29184187
68MYC_22102868_ChIP-Seq_BL_Human1.29114884
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.28878477
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28808837
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.27504774
72* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24410947
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21768494
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21592139
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21343705
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20791249
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20031903
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19749748
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.19453524
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19376727
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14537836
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14478421
83* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12698146
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09843962
85TFEB_21752829_ChIP-Seq_HELA_Human1.08896568
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07593782
87VDR_22108803_ChIP-Seq_LS180_Human1.07177490
88IGF1R_20145208_ChIP-Seq_DFB_Human1.06365974
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04892945
90MYC_18940864_ChIP-ChIP_HL60_Human1.02192662
91IRF1_19129219_ChIP-ChIP_H3396_Human0.98766203
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96479152
93SPI1_23547873_ChIP-Seq_NB4_Human0.95900279
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95343855
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94659718
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94659718
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94659718
98P300_19829295_ChIP-Seq_ESCs_Human0.93886199
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92555944
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.91818741
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91471840
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89232425
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88958226
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88938129
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88537457
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86127230
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85921962
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85621127
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.84862727
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84615490
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84283358
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83803063
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81953842
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81701261
115* NANOG_21062744_ChIP-ChIP_HESCs_Human0.81539997
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81350974
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80217567
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79775905
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79246254
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75586182
121TAF15_26573619_Chip-Seq_HEK293_Human0.71660693
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70251697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.17408548
2MP0010094_abnormal_chromosome_stability4.63143076
3MP0008057_abnormal_DNA_replication4.40040509
4MP0003111_abnormal_nucleus_morphology4.18370126
5MP0004957_abnormal_blastocyst_morpholog4.14776987
6MP0003077_abnormal_cell_cycle3.91096695
7MP0008058_abnormal_DNA_repair3.47794999
8MP0008007_abnormal_cellular_replicative2.79881077
9MP0008932_abnormal_embryonic_tissue2.53919238
10MP0003123_paternal_imprinting2.41708664
11MP0002396_abnormal_hematopoietic_system2.41674640
12MP0001730_embryonic_growth_arrest2.18568999
13MP0000350_abnormal_cell_proliferation2.16810083
14MP0008877_abnormal_DNA_methylation2.06085764
15MP0000490_abnormal_crypts_of2.05347898
16MP0003718_maternal_effect2.03335958
17MP0010307_abnormal_tumor_latency1.96678147
18MP0010352_gastrointestinal_tract_polyps1.92147880
19MP0003786_premature_aging1.86643603
20MP0002254_reproductive_system_inflammat1.73979332
21MP0005380_embryogenesis_phenotype1.72150500
22MP0001672_abnormal_embryogenesis/_devel1.72150500
23MP0001697_abnormal_embryo_size1.65786968
24MP0003806_abnormal_nucleotide_metabolis1.63704227
25MP0003984_embryonic_growth_retardation1.52602060
26MP0002088_abnormal_embryonic_growth/wei1.49931158
27MP0001529_abnormal_vocalization1.49577507
28MP0002019_abnormal_tumor_incidence1.46808231
29MP0001188_hyperpigmentation1.46240531
30MP0002080_prenatal_lethality1.45322320
31MP0009333_abnormal_splenocyte_physiolog1.45057769
32MP0002085_abnormal_embryonic_tissue1.43760245
33MP0000313_abnormal_cell_death1.42403654
34MP0004808_abnormal_hematopoietic_stem1.41472632
35MP0003890_abnormal_embryonic-extraembry1.40262337
36MP0003121_genomic_imprinting1.38592504
37MP0002086_abnormal_extraembryonic_tissu1.37157794
38MP0002084_abnormal_developmental_patter1.36921479
39MP0006035_abnormal_mitochondrial_morpho1.30877121
40MP0008789_abnormal_olfactory_epithelium1.29505533
41MP0009703_decreased_birth_body1.29477990
42MP0004197_abnormal_fetal_growth/weight/1.28225495
43MP0003763_abnormal_thymus_physiology1.25871851
44MP0001293_anophthalmia1.24923719
45MP0006072_abnormal_retinal_apoptosis1.24197837
46MP0003186_abnormal_redox_activity1.23739635
47MP0002398_abnormal_bone_marrow1.21980711
48MP0003567_abnormal_fetal_cardiomyocyte1.19666024
49MP0003941_abnormal_skin_development1.15816270
50MP0000703_abnormal_thymus_morphology1.15005290
51MP0005397_hematopoietic_system_phenotyp1.14937677
52MP0001545_abnormal_hematopoietic_system1.14937677
53MP0006292_abnormal_olfactory_placode1.12908475
54MP0002751_abnormal_autonomic_nervous1.11331769
55MP0002722_abnormal_immune_system1.09836586
56MP0002697_abnormal_eye_size1.08773434
57MP0000689_abnormal_spleen_morphology1.07801278
58MP0010030_abnormal_orbit_morphology1.06632409
59MP0002210_abnormal_sex_determination1.06552760
60MP0002233_abnormal_nose_morphology1.03499401
61MP0002102_abnormal_ear_morphology1.01877490
62MP0004133_heterotaxia1.00726050
63MP0003436_decreased_susceptibility_to1.00250490
64MP0001177_atelectasis0.99193529
65MP0001119_abnormal_female_reproductive0.99054763
66MP0000647_abnormal_sebaceous_gland0.98324626
67MP0003315_abnormal_perineum_morphology0.96801777
68MP0005394_taste/olfaction_phenotype0.96557956
69MP0005499_abnormal_olfactory_system0.96557956
70MP0001800_abnormal_humoral_immune0.96409182
71MP0001835_abnormal_antigen_presentation0.96180328
72MP0001145_abnormal_male_reproductive0.96166804
73MP0002429_abnormal_blood_cell0.96037988
74MP0006054_spinal_hemorrhage0.93913913
75MP0000049_abnormal_middle_ear0.89247920
76MP0005076_abnormal_cell_differentiation0.87918090
77MP0000653_abnormal_sex_gland0.87583894
78MP0003221_abnormal_cardiomyocyte_apopto0.86830204
79MP0000716_abnormal_immune_system0.86652752
80MP0000858_altered_metastatic_potential0.86367635
81MP0005367_renal/urinary_system_phenotyp0.85816715
82MP0000516_abnormal_urinary_system0.85816715
83MP0002132_abnormal_respiratory_system0.85788954
84MP0001915_intracranial_hemorrhage0.85486855
85MP0001853_heart_inflammation0.85461307
86MP0004147_increased_porphyrin_level0.85142493
87MP0000428_abnormal_craniofacial_morphol0.84552296
88MP0003136_yellow_coat_color0.83928247
89MP0002452_abnormal_antigen_presenting0.83481630
90MP0002148_abnormal_hypersensitivity_rea0.83017420
91MP0005023_abnormal_wound_healing0.81445184
92MP0009785_altered_susceptibility_to0.81322776
93MP0003937_abnormal_limbs/digits/tail_de0.81001533
94MP0005671_abnormal_response_to0.80619823
95MP0006036_abnormal_mitochondrial_physio0.80266241
96MP0000358_abnormal_cell_content/0.80159319
97MP0001929_abnormal_gametogenesis0.79807366
98MP0002420_abnormal_adaptive_immunity0.78677561
99MP0001819_abnormal_immune_cell0.77958922
100MP0005384_cellular_phenotype0.76666412
101MP0000383_abnormal_hair_follicle0.76398908
102MP0002111_abnormal_tail_morphology0.75788597
103MP0002723_abnormal_immune_serum0.75546429
104MP0009672_abnormal_birth_weight0.74673589
105MP0003755_abnormal_palate_morphology0.74300405
106MP0005391_vision/eye_phenotype0.73992901
107MP0003698_abnormal_male_reproductive0.72836165
108MP0002090_abnormal_vision0.72808920
109MP0001299_abnormal_eye_distance/0.71985138
110MP0003861_abnormal_nervous_system0.70808756
111MP0002405_respiratory_system_inflammati0.70808322
112MP0005000_abnormal_immune_tolerance0.70257457
113MP0005621_abnormal_cell_physiology0.70067892
114MP0001286_abnormal_eye_development0.67486469
115MP0010678_abnormal_skin_adnexa0.67476640
116MP0003943_abnormal_hepatobiliary_system0.66823350
117MP0003935_abnormal_craniofacial_develop0.66517939
118MP0009697_abnormal_copulation0.66377735
119MP0003448_altered_tumor_morphology0.66065177
120MP0008995_early_reproductive_senescence0.65757237
121MP0005253_abnormal_eye_physiology0.64335166
122MP0002006_tumorigenesis0.63432164
123MP0000372_irregular_coat_pigmentation0.62960868
124MP0005389_reproductive_system_phenotype0.62468426
125MP0005075_abnormal_melanosome_morpholog0.61909852
126MP0002092_abnormal_eye_morphology0.61648057
127MP0002796_impaired_skin_barrier0.61381765
128MP0000432_abnormal_head_morphology0.61334786
129MP0005395_other_phenotype0.61188604
130MP0003119_abnormal_digestive_system0.60969901
131MP0003566_abnormal_cell_adhesion0.60608469
132MP0002160_abnormal_reproductive_system0.58481659
133MP0001986_abnormal_taste_sensitivity0.58062966
134MP0000427_abnormal_hair_cycle0.57607866
135MP0005025_abnormal_response_to0.57526741
136MP0000477_abnormal_intestine_morphology0.57243151
137MP0002161_abnormal_fertility/fecundity0.57063051
138MP0002938_white_spotting0.54717036
139MP0002653_abnormal_ependyma_morphology0.53622721

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.21920939
2Chromsome breakage (HP:0040012)4.73349417
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12030509
4Reticulocytopenia (HP:0001896)3.77481019
5Breast hypoplasia (HP:0003187)3.71772744
6Aplastic anemia (HP:0001915)3.31548818
7Patellar aplasia (HP:0006443)3.29916318
8Abnormality of the anterior horn cell (HP:0006802)3.25030952
9Degeneration of anterior horn cells (HP:0002398)3.25030952
10Abnormality of chromosome stability (HP:0003220)3.17307333
11Oral leukoplakia (HP:0002745)3.14645156
12Medulloblastoma (HP:0002885)3.11092647
13Aplasia/Hypoplasia of the patella (HP:0006498)3.03898997
14Meckel diverticulum (HP:0002245)3.03639996
15Supernumerary spleens (HP:0009799)3.03509915
16Colon cancer (HP:0003003)2.98158457
17Abnormality of the preputium (HP:0100587)2.95461991
18Absent radius (HP:0003974)2.93341014
19Agnosia (HP:0010524)2.90716060
20Myelodysplasia (HP:0002863)2.85516743
21Abnormality of the ileum (HP:0001549)2.85369621
22Impulsivity (HP:0100710)2.82905433
23Rough bone trabeculation (HP:0100670)2.80362222
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.77906170
25Abnormality of methionine metabolism (HP:0010901)2.76612122
26Aplasia involving forearm bones (HP:0009822)2.70377826
27Absent forearm bone (HP:0003953)2.70377826
28Carpal bone hypoplasia (HP:0001498)2.69924516
2911 pairs of ribs (HP:0000878)2.68772102
30Abnormality of the labia minora (HP:0012880)2.67478311
31Selective tooth agenesis (HP:0001592)2.65789156
32Abnormality of cells of the erythroid lineage (HP:0012130)2.60833207
33Bone marrow hypocellularity (HP:0005528)2.60421351
34Cortical dysplasia (HP:0002539)2.60125063
35Abnormal lung lobation (HP:0002101)2.58571402
36Cerebral hypomyelination (HP:0006808)2.56994580
37Duodenal stenosis (HP:0100867)2.56640235
38Small intestinal stenosis (HP:0012848)2.56640235
39Ependymoma (HP:0002888)2.53666115
40Abnormal number of incisors (HP:0011064)2.53605292
41Absent thumb (HP:0009777)2.47190725
42Abnormal number of erythroid precursors (HP:0012131)2.45560492
43Hyperglycinemia (HP:0002154)2.44900354
44Premature graying of hair (HP:0002216)2.43459910
45Multiple enchondromatosis (HP:0005701)2.41903805
46Microvesicular hepatic steatosis (HP:0001414)2.41490863
47Rhabdomyosarcoma (HP:0002859)2.40482788
48Sloping forehead (HP:0000340)2.39564922
49Methylmalonic acidemia (HP:0002912)2.39504166
50Duplicated collecting system (HP:0000081)2.37126654
51Neoplasm of the pancreas (HP:0002894)2.33685495
52Abnormality of serum amino acid levels (HP:0003112)2.33659453
53Increased nuchal translucency (HP:0010880)2.33232349
54Ectopic kidney (HP:0000086)2.31198650
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30730982
56Horseshoe kidney (HP:0000085)2.28743579
57Glioma (HP:0009733)2.26885629
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.26509327
59Cleft eyelid (HP:0000625)2.23889005
60Increased hepatocellular lipid droplets (HP:0006565)2.22903816
61Cellular immunodeficiency (HP:0005374)2.18912086
62Abnormality of the duodenum (HP:0002246)2.18130475
63Macrocytic anemia (HP:0001972)2.17795654
64Glossoptosis (HP:0000162)2.16125498
65Pallor (HP:0000980)2.15816147
66Biliary tract neoplasm (HP:0100574)2.15343845
67Abnormality of the renal collecting system (HP:0004742)2.15009655
68Deviation of the thumb (HP:0009603)2.12654240
69Pancreatic islet-cell hyperplasia (HP:0004510)2.11582263
70Nephroblastoma (Wilms tumor) (HP:0002667)2.09345821
71Abnormality of serine family amino acid metabolism (HP:0010894)2.08752162
72Abnormality of glycine metabolism (HP:0010895)2.08752162
73Abnormality of pyrimidine metabolism (HP:0004353)2.07187026
74Triphalangeal thumb (HP:0001199)2.02947387
75Premature ovarian failure (HP:0008209)2.02465086
76Septo-optic dysplasia (HP:0100842)2.02208190
77Facial cleft (HP:0002006)2.01611090
78Proximal placement of thumb (HP:0009623)2.00255839
79Atresia of the external auditory canal (HP:0000413)1.98737375
80Tracheoesophageal fistula (HP:0002575)1.97462246
81Abnormal trabecular bone morphology (HP:0100671)1.97429016
82Postnatal microcephaly (HP:0005484)1.97149025
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96976032
84Amaurosis fugax (HP:0100576)1.96881624
85Abnormality of the astrocytes (HP:0100707)1.96601299
86Astrocytoma (HP:0009592)1.96601299
87Spastic diplegia (HP:0001264)1.96413783
88Short thumb (HP:0009778)1.96322795
89Embryonal renal neoplasm (HP:0011794)1.95141054
90Pancytopenia (HP:0001876)1.95057463
91Stenosis of the external auditory canal (HP:0000402)1.93555701
92Secondary amenorrhea (HP:0000869)1.93219192
93Basal cell carcinoma (HP:0002671)1.93041691
94Lipid accumulation in hepatocytes (HP:0006561)1.92695385
95Lymphoma (HP:0002665)1.92375589
96Type I transferrin isoform profile (HP:0003642)1.91937263
97Hyperglycinuria (HP:0003108)1.91507780
98Methylmalonic aciduria (HP:0012120)1.91051000
99Gonadotropin excess (HP:0000837)1.89887930
100Neoplasm of the colon (HP:0100273)1.88836911
101Neoplasm of the oral cavity (HP:0100649)1.86979456
102Irregular epiphyses (HP:0010582)1.86585927
103Megaloblastic anemia (HP:0001889)1.86031000
104Trismus (HP:0000211)1.85808309
105Ovarian neoplasm (HP:0100615)1.85588977
106Embryonal neoplasm (HP:0002898)1.81527376
107Abnormality of the septum pellucidum (HP:0007375)1.81154263
108Reduced antithrombin III activity (HP:0001976)1.80024937
109Squamous cell carcinoma (HP:0002860)1.79812714
110Thrombocytosis (HP:0001894)1.79346068
111Asplenia (HP:0001746)1.79311861
112Choanal atresia (HP:0000453)1.79243472
113Homocystinuria (HP:0002156)1.78524517
114Abnormality of homocysteine metabolism (HP:0010919)1.78524517
115Bifid tongue (HP:0010297)1.78440873
116Abnormality of DNA repair (HP:0003254)1.77378632
117Clubbing of toes (HP:0100760)1.76865037
118Abnormality of glycolysis (HP:0004366)1.76658057
119Increased serum pyruvate (HP:0003542)1.76658057
120Missing ribs (HP:0000921)1.76100088
121Cafe-au-lait spot (HP:0000957)1.75816622
122Acute encephalopathy (HP:0006846)1.75344602
123Acute myeloid leukemia (HP:0004808)1.73917600
124Volvulus (HP:0002580)1.73759934
125Neoplasm of the small intestine (HP:0100833)1.73402676
126Abnormality of abdominal situs (HP:0011620)1.71266616
127Abdominal situs inversus (HP:0003363)1.71266616
128Abnormality of the calcaneus (HP:0008364)1.70844441
129Absent septum pellucidum (HP:0001331)1.69389747
130Neoplasm of striated muscle (HP:0009728)1.69146870
131Median cleft lip (HP:0000161)1.68471212
132Abnormality of the carotid arteries (HP:0005344)1.68230817
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.67287908
134Optic nerve coloboma (HP:0000588)1.67180882
135Aseptic necrosis (HP:0010885)1.65703619
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65612314
137Abnormal protein N-linked glycosylation (HP:0012347)1.65612314
138Abnormal protein glycosylation (HP:0012346)1.65612314
139Abnormal glycosylation (HP:0012345)1.65612314
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65378174
141Abnormality of alanine metabolism (HP:0010916)1.65378174
142Hyperalaninemia (HP:0003348)1.65378174
143Hypoplastic pelvis (HP:0008839)1.65231629
144Intestinal atresia (HP:0011100)1.65220746
145Spinal muscular atrophy (HP:0007269)1.64912828
146Increased serum lactate (HP:0002151)1.64552676
147IgM deficiency (HP:0002850)1.64289831
148Neoplasm of the adrenal gland (HP:0100631)1.64021894
149Abnormality of the clitoris (HP:0000056)1.63278604
150Increased CSF lactate (HP:0002490)1.62959523
151Leukopenia (HP:0001882)1.62938133
152Breast carcinoma (HP:0003002)1.62337636
153Shoulder girdle muscle weakness (HP:0003547)1.62302693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.34273276
2WEE14.14068172
3CDC73.78759384
4SRPK12.98097075
5EIF2AK12.80348156
6TRIM282.71835241
7PLK42.62928459
8TTK2.60957130
9MKNK12.39792301
10NEK22.35724706
11TSSK62.34979407
12STK162.27229887
13BRSK22.16211121
14ACVR1B2.02596421
15PLK11.98080553
16VRK11.82183109
17CDK71.82173296
18ATR1.80314981
19TAF11.75886697
20PASK1.75097019
21VRK21.72505501
22PLK31.70788459
23WNK31.70621354
24TGFBR11.70497594
25NME21.68385426
26RPS6KB21.65060056
27AURKB1.64838858
28STK101.59549078
29BCR1.57008692
30EIF2AK31.55846553
31TLK11.51821634
32CHEK21.51375312
33NEK11.43515417
34CDK121.42631114
35RPS6KA41.36755566
36MAP3K81.36172912
37TNIK1.35260590
38DYRK31.33364636
39MKNK21.32685975
40EPHA21.28567406
41CHEK11.27231592
42FLT31.25397684
43ZAK1.23096821
44AURKA1.22683289
45TESK21.13303626
46PIM11.07810255
47BRSK11.04322725
48MAP4K21.02256035
49CDK41.01143426
50ATM0.98090465
51PLK20.97891028
52CDK190.94876380
53STK40.94131594
54CSNK1G10.91217119
55MELK0.90822615
56EIF2AK20.89487273
57MAP3K40.89385540
58MAP4K10.86527100
59TRPM70.83747476
60STK30.83399728
61PNCK0.82005270
62CDK20.81397217
63CCNB10.81060448
64EEF2K0.78534942
65STK38L0.77696597
66PIM20.77469173
67NUAK10.77340306
68JAK30.76214395
69MAP3K120.71126422
70BRAF0.68360995
71DYRK20.68037842
72RPS6KA50.66795990
73MST40.66735523
74CSNK1G20.66517345
75FGFR10.66386696
76CHUK0.65428561
77CSNK2A10.65196995
78CSNK1G30.65114539
79CSNK2A20.64707430
80PAK40.64367059
81TEC0.64138542
82BCKDK0.63503627
83NME10.61413853
84CDK10.61377159
85LATS10.60951375
86BRD40.60526658
87IRAK40.58858056
88MAP3K100.56712777
89PAK10.55707994
90BTK0.55546096
91MAP3K110.54984614
92MAP3K50.54841866
93TXK0.54176204
94CDK80.54105512
95KIT0.53496433
96SCYL20.51768877
97IKBKB0.51532387
98TAOK20.51149594
99ERBB30.50974895
100PBK0.50508212
101ALK0.50397814
102MAP3K30.50270637
103MAP3K140.49032437
104CSNK1A1L0.48456574
105CDK60.48026353
106PRKCI0.45821116
107LRRK20.45749804
108TYK20.43904748
109RAF10.43411165
110CDK30.42371121
111YES10.42348001
112CSNK1E0.42167642
113PKN20.41803134
114FRK0.40375951
115MAP2K70.39250159
116NLK0.39147948
117OXSR10.35747895
118SIK30.35139585
119STK240.34719743
120LYN0.33971094
121ERBB40.31529212
122CLK10.31264420
123GRK60.30410708
124MAP2K30.29408565
125PRKDC0.27973151
126BMPR1B0.27372716
127EGFR0.24155857
128CSNK1D0.22410846
129PDK20.21194850
130STK390.18752983
131MINK10.17631590
132DAPK10.13977566

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70819738
2Mismatch repair_Homo sapiens_hsa034304.19210764
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56141451
4RNA polymerase_Homo sapiens_hsa030203.17111112
5Spliceosome_Homo sapiens_hsa030403.08461398
6Base excision repair_Homo sapiens_hsa034103.00541084
7* RNA transport_Homo sapiens_hsa030132.98349396
8Homologous recombination_Homo sapiens_hsa034402.93621609
9Proteasome_Homo sapiens_hsa030502.87441101
10One carbon pool by folate_Homo sapiens_hsa006702.80603283
11Nucleotide excision repair_Homo sapiens_hsa034202.80455854
12Ribosome_Homo sapiens_hsa030102.74818615
13Cell cycle_Homo sapiens_hsa041102.67972695
14Non-homologous end-joining_Homo sapiens_hsa034502.66753391
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39527871
16Pyrimidine metabolism_Homo sapiens_hsa002402.35741218
17Fanconi anemia pathway_Homo sapiens_hsa034602.22341657
18RNA degradation_Homo sapiens_hsa030182.11868590
19Basal transcription factors_Homo sapiens_hsa030221.89561672
20Propanoate metabolism_Homo sapiens_hsa006401.77374254
21mRNA surveillance pathway_Homo sapiens_hsa030151.58118080
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57187295
23p53 signaling pathway_Homo sapiens_hsa041151.56227530
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39470553
25Pyruvate metabolism_Homo sapiens_hsa006201.27039391
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26155812
27Epstein-Barr virus infection_Homo sapiens_hsa051691.25058408
28Steroid biosynthesis_Homo sapiens_hsa001001.22765646
29Fatty acid elongation_Homo sapiens_hsa000621.22413926
30Herpes simplex infection_Homo sapiens_hsa051681.20708851
31Systemic lupus erythematosus_Homo sapiens_hsa053221.17063557
32Purine metabolism_Homo sapiens_hsa002301.16461142
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16138949
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15741476
35Vitamin B6 metabolism_Homo sapiens_hsa007501.11665336
36Parkinsons disease_Homo sapiens_hsa050121.09585937
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08380765
38Antigen processing and presentation_Homo sapiens_hsa046121.07101596
39Viral carcinogenesis_Homo sapiens_hsa052030.97309265
40Oxidative phosphorylation_Homo sapiens_hsa001900.96111177
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94860190
42Legionellosis_Homo sapiens_hsa051340.87104782
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84066520
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.80771794
45Selenocompound metabolism_Homo sapiens_hsa004500.77719841
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.76465116
47Folate biosynthesis_Homo sapiens_hsa007900.75917968
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.75066819
49Graft-versus-host disease_Homo sapiens_hsa053320.70849207
50HTLV-I infection_Homo sapiens_hsa051660.70439107
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70366218
52Allograft rejection_Homo sapiens_hsa053300.70360742
53Measles_Homo sapiens_hsa051620.69682817
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69627113
55Biosynthesis of amino acids_Homo sapiens_hsa012300.68244559
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67556602
57Pentose phosphate pathway_Homo sapiens_hsa000300.66355374
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65479618
59Oocyte meiosis_Homo sapiens_hsa041140.65284788
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64245226
61MicroRNAs in cancer_Homo sapiens_hsa052060.62806797
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58337825
63Protein export_Homo sapiens_hsa030600.57555532
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57418945
65Small cell lung cancer_Homo sapiens_hsa052220.57394032
66Primary immunodeficiency_Homo sapiens_hsa053400.56764319
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54007802
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53165950
69Apoptosis_Homo sapiens_hsa042100.53078016
70beta-Alanine metabolism_Homo sapiens_hsa004100.51926376
71Glutathione metabolism_Homo sapiens_hsa004800.49422994
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49328339
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49257881
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48861877
75TGF-beta signaling pathway_Homo sapiens_hsa043500.48410640
76Caffeine metabolism_Homo sapiens_hsa002320.46593077
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46198231
78Influenza A_Homo sapiens_hsa051640.44949312
79Hepatitis B_Homo sapiens_hsa051610.43995370
80Leishmaniasis_Homo sapiens_hsa051400.42924563
81Wnt signaling pathway_Homo sapiens_hsa043100.42538199
82N-Glycan biosynthesis_Homo sapiens_hsa005100.41916447
83Alzheimers disease_Homo sapiens_hsa050100.40969053
84Fatty acid metabolism_Homo sapiens_hsa012120.39834293
85Thyroid cancer_Homo sapiens_hsa052160.39320139
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.37963943
87Hematopoietic cell lineage_Homo sapiens_hsa046400.37891641
88Colorectal cancer_Homo sapiens_hsa052100.37274144
89Alcoholism_Homo sapiens_hsa050340.36106456
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35605989
91Notch signaling pathway_Homo sapiens_hsa043300.35470582
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34534979
93Asthma_Homo sapiens_hsa053100.33857305
94Lysine degradation_Homo sapiens_hsa003100.31640070
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31512961
96Vitamin digestion and absorption_Homo sapiens_hsa049770.30505308
97Shigellosis_Homo sapiens_hsa051310.29993832
98Peroxisome_Homo sapiens_hsa041460.28516413
99Butanoate metabolism_Homo sapiens_hsa006500.28342497
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.28255342
101Carbon metabolism_Homo sapiens_hsa012000.27552509
102Type I diabetes mellitus_Homo sapiens_hsa049400.26747277
103Adherens junction_Homo sapiens_hsa045200.25737545
104Arachidonic acid metabolism_Homo sapiens_hsa005900.25679205
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.25282385
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25181518
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24587986
108Viral myocarditis_Homo sapiens_hsa054160.24230339
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23559534
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23265396
111TNF signaling pathway_Homo sapiens_hsa046680.23263163
112Hedgehog signaling pathway_Homo sapiens_hsa043400.22894880
113Chronic myeloid leukemia_Homo sapiens_hsa052200.22543453
114Hippo signaling pathway_Homo sapiens_hsa043900.21820291
115Autoimmune thyroid disease_Homo sapiens_hsa053200.21796232
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20822088
117Fatty acid degradation_Homo sapiens_hsa000710.20506433
118Basal cell carcinoma_Homo sapiens_hsa052170.20446492
119Arginine and proline metabolism_Homo sapiens_hsa003300.19867871
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19637857
121Huntingtons disease_Homo sapiens_hsa050160.18995126
122Pathways in cancer_Homo sapiens_hsa052000.17590932
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17433416
124Regulation of autophagy_Homo sapiens_hsa041400.17025444
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16696393
126Acute myeloid leukemia_Homo sapiens_hsa052210.16049287
127Metabolic pathways_Homo sapiens_hsa011000.15741669
128HIF-1 signaling pathway_Homo sapiens_hsa040660.15045606
129Linoleic acid metabolism_Homo sapiens_hsa005910.14696165
130Ether lipid metabolism_Homo sapiens_hsa005650.14621421
131Prostate cancer_Homo sapiens_hsa052150.14601711
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14177256
133Renin-angiotensin system_Homo sapiens_hsa046140.13612125
134Tight junction_Homo sapiens_hsa045300.12389338
135Phototransduction_Homo sapiens_hsa047440.12322931
136Tryptophan metabolism_Homo sapiens_hsa003800.08365077
137Sulfur metabolism_Homo sapiens_hsa009200.06087901
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04868475

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