NUP43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.84144316
2DNA replication initiation (GO:0006270)4.75557843
3mitotic metaphase plate congression (GO:0007080)4.75191584
4nucleobase biosynthetic process (GO:0046112)4.74839593
5purine nucleobase biosynthetic process (GO:0009113)4.72488690
6formation of translation preinitiation complex (GO:0001731)4.65141087
7DNA replication checkpoint (GO:0000076)4.63224304
8DNA strand elongation (GO:0022616)4.60161006
9maturation of SSU-rRNA (GO:0030490)4.49685293
10telomere maintenance via semi-conservative replication (GO:0032201)4.49165046
11CENP-A containing nucleosome assembly (GO:0034080)4.34369343
12chromatin remodeling at centromere (GO:0031055)4.27452165
13protein localization to kinetochore (GO:0034501)4.14428655
14sister chromatid segregation (GO:0000819)4.11541461
15metaphase plate congression (GO:0051310)4.11329723
16telomere maintenance via recombination (GO:0000722)4.08783296
17ribosome assembly (GO:0042255)4.07573934
18mitotic sister chromatid cohesion (GO:0007064)4.06244200
19replication fork processing (GO:0031297)4.02725929
20ribosome biogenesis (GO:0042254)4.02444107
21DNA unwinding involved in DNA replication (GO:0006268)3.97555951
22regulation of centriole replication (GO:0046599)3.89252404
23kinetochore organization (GO:0051383)3.89240370
24DNA replication-dependent nucleosome organization (GO:0034723)3.88513306
25DNA replication-dependent nucleosome assembly (GO:0006335)3.88513306
26mitotic recombination (GO:0006312)3.87490106
27DNA replication-independent nucleosome organization (GO:0034724)3.86518584
28DNA replication-independent nucleosome assembly (GO:0006336)3.86518584
29ribosomal small subunit assembly (GO:0000028)3.82787010
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.81659340
31ribonucleoprotein complex biogenesis (GO:0022613)3.79655058
32ribosomal large subunit biogenesis (GO:0042273)3.77357615
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.74876435
34spliceosomal snRNP assembly (GO:0000387)3.74850317
35kinetochore assembly (GO:0051382)3.71708342
36histone exchange (GO:0043486)3.71661427
37pore complex assembly (GO:0046931)3.71405646
38IMP biosynthetic process (GO:0006188)3.71222468
39regulation of DNA endoreduplication (GO:0032875)3.68734393
40telomere maintenance via telomere lengthening (GO:0010833)3.68180002
41proteasome assembly (GO:0043248)3.65436374
42* mitotic nuclear envelope disassembly (GO:0007077)3.64710617
43rRNA modification (GO:0000154)3.63644832
44establishment of chromosome localization (GO:0051303)3.63570443
45attachment of spindle microtubules to kinetochore (GO:0008608)3.61804473
46non-recombinational repair (GO:0000726)3.59163567
47double-strand break repair via nonhomologous end joining (GO:0006303)3.59163567
48regulation of spindle organization (GO:0090224)3.57997423
49nuclear pore organization (GO:0006999)3.56344714
50protein localization to chromosome, centromeric region (GO:0071459)3.55053050
51rRNA processing (GO:0006364)3.52870646
52DNA strand renaturation (GO:0000733)3.52859767
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.52843890
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50785286
55DNA deamination (GO:0045006)3.47959364
56rRNA metabolic process (GO:0016072)3.41541808
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40059666
58DNA double-strand break processing (GO:0000729)3.39987294
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39874626
60transcription-coupled nucleotide-excision repair (GO:0006283)3.39475867
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39191741
62regulation of centrosome cycle (GO:0046605)3.38928665
63ribosomal small subunit biogenesis (GO:0042274)3.38769361
64synapsis (GO:0007129)3.37178987
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35851090
66mitotic sister chromatid segregation (GO:0000070)3.35448880
67* membrane disassembly (GO:0030397)3.34146741
68* nuclear envelope disassembly (GO:0051081)3.34146741
69establishment of integrated proviral latency (GO:0075713)3.31732586
70maturation of 5.8S rRNA (GO:0000460)3.30725050
71folic acid-containing compound biosynthetic process (GO:0009396)3.30497030
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.28923306
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28923306
74translational initiation (GO:0006413)3.28606679
75DNA ligation (GO:0006266)3.28364503
76nuclear pore complex assembly (GO:0051292)3.27835724
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27016269
78regulation of mitotic spindle checkpoint (GO:1903504)3.27016269
79translational termination (GO:0006415)3.26906401
80termination of RNA polymerase III transcription (GO:0006386)3.26369808
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.26369808
82viral transcription (GO:0019083)3.25886025
83spindle checkpoint (GO:0031577)3.25343928
84pseudouridine synthesis (GO:0001522)3.23505458
85regulation of chromosome segregation (GO:0051983)3.22465670
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.22086975
87termination of RNA polymerase I transcription (GO:0006363)3.20599231
88cell cycle G1/S phase transition (GO:0044843)3.19896865
89G1/S transition of mitotic cell cycle (GO:0000082)3.19896865
90protein K6-linked ubiquitination (GO:0085020)3.19896039
91mitotic chromosome condensation (GO:0007076)3.18945774
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18872613
93negative regulation of sister chromatid segregation (GO:0033046)3.18872613
94negative regulation of mitotic sister chromatid separation (GO:2000816)3.18872613
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18872613
96negative regulation of chromosome segregation (GO:0051985)3.18740178
977-methylguanosine mRNA capping (GO:0006370)3.17630827
98IMP metabolic process (GO:0046040)3.17241484
99spliceosomal complex assembly (GO:0000245)3.16253468
100cullin deneddylation (GO:0010388)3.15737638
101meiotic chromosome segregation (GO:0045132)3.15166124
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.15113305
103transcription elongation from RNA polymerase I promoter (GO:0006362)3.14739180
104RNA capping (GO:0036260)3.13481357
1057-methylguanosine RNA capping (GO:0009452)3.13481357
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12574073
107regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12568345
108viral mRNA export from host cell nucleus (GO:0046784)3.12240560
109transcription from RNA polymerase I promoter (GO:0006360)3.11674635
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11099770
111positive regulation of chromosome segregation (GO:0051984)3.11067349
112double-strand break repair via homologous recombination (GO:0000724)3.10099385
113spindle assembly checkpoint (GO:0071173)3.09524689
114recombinational repair (GO:0000725)3.09434178
115mitotic spindle assembly checkpoint (GO:0007094)3.08579772
116regulation of mitotic spindle organization (GO:0060236)3.08247141
117mitotic spindle checkpoint (GO:0071174)3.08227790
118folic acid metabolic process (GO:0046655)3.07925305
119negative regulation of ligase activity (GO:0051352)3.07199850
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07199850
121regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07077506
122regulation of sister chromatid segregation (GO:0033045)3.06418312
123regulation of mitotic sister chromatid separation (GO:0010965)3.06418312
124regulation of mitotic sister chromatid segregation (GO:0033047)3.06418312
125regulation of centrosome duplication (GO:0010824)3.05858811
126postreplication repair (GO:0006301)3.04465476
127DNA catabolic process, exonucleolytic (GO:0000738)3.01355750
128resolution of meiotic recombination intermediates (GO:0000712)2.99630032
129microtubule depolymerization (GO:0007019)2.97583154
130mitotic G2/M transition checkpoint (GO:0044818)2.97153136
131DNA topological change (GO:0006265)2.95943431
132RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93954835
133chromatin assembly or disassembly (GO:0006333)2.89959687
134L-serine metabolic process (GO:0006563)2.88648837
135telomere maintenance (GO:0000723)2.86132846
136DNA geometric change (GO:0032392)2.85205317
137negative regulation of DNA recombination (GO:0045910)2.84588456
138DNA duplex unwinding (GO:0032508)2.83441121
139telomere organization (GO:0032200)2.83397367
140* chromosome segregation (GO:0007059)2.81614630
141intra-S DNA damage checkpoint (GO:0031573)2.81036224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.62480001
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53284376
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.85408755
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82586358
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72377524
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55168479
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.27063534
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19467650
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18653211
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.15939029
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12734274
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.05935505
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.03173559
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99447883
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94904799
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55031084
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53603111
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52495716
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50412905
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45005841
21AR_21909140_ChIP-Seq_LNCAP_Human2.35926440
22* XRN2_22483619_ChIP-Seq_HELA_Human2.34698378
23* VDR_23849224_ChIP-Seq_CD4+_Human2.31900138
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17226657
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12659214
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09076616
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05812936
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01428786
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.01425128
30MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00028119
31DCP1A_22483619_ChIP-Seq_HELA_Human1.97748802
32ZNF274_21170338_ChIP-Seq_K562_Hela1.97107563
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.96617330
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92245383
35GABP_19822575_ChIP-Seq_HepG2_Human1.91956329
36* TTF2_22483619_ChIP-Seq_HELA_Human1.90156252
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90144189
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89250318
39FUS_26573619_Chip-Seq_HEK293_Human1.88407785
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86405685
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84335000
42EWS_26573619_Chip-Seq_HEK293_Human1.83183069
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81732760
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76072255
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74357463
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.72524739
47ELK1_19687146_ChIP-ChIP_HELA_Human1.69828427
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67083061
49VDR_22108803_ChIP-Seq_LS180_Human1.64522587
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62200186
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57363515
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56589762
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54839428
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.54646523
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53729172
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53009938
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50570905
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46880301
59CIITA_25753668_ChIP-Seq_RAJI_Human1.46829884
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41036722
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40033424
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37449358
63KDM5A_27292631_Chip-Seq_BREAST_Human1.37427545
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31909272
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31080341
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.28808439
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27867889
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.27620376
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25208446
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24470602
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24376737
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24185204
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23216995
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.22682074
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22189150
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.21731472
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.19751301
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19542589
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16399783
80* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15719701
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13734008
82MYC_18940864_ChIP-ChIP_HL60_Human1.08834793
83IRF1_19129219_ChIP-ChIP_H3396_Human1.08635472
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08620468
85IGF1R_20145208_ChIP-Seq_DFB_Human1.07493170
86TAF15_26573619_Chip-Seq_HEK293_Human1.06808714
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04873265
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04312540
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03493487
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02705684
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02705684
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02705684
93P300_19829295_ChIP-Seq_ESCs_Human1.00976545
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.00697097
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.99320115
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99303655
97TFEB_21752829_ChIP-Seq_HELA_Human0.98632103
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97678363
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97187327
100* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95981987
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95641310
102* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95408518
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95326858
104* SALL1_21062744_ChIP-ChIP_HESCs_Human0.94748567
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94631677
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.93428848
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91707640
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91233140
109MYC_22102868_ChIP-Seq_BL_Human0.90876677
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.89416885
111* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88010341
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86941813
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86360708
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85785466
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85016080
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84860010
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84742233
118ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84327468
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84116134
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83380914
121* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80304257
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79959796
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79254314
124SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79206654
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78883345
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76966903
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75908345
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.74875703
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74758600
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74677813
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.73754763
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.73296591
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.71580442
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.71572006
135ER_23166858_ChIP-Seq_MCF-7_Human0.67857725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.92520274
2MP0010094_abnormal_chromosome_stability5.03435384
3MP0003111_abnormal_nucleus_morphology4.75853354
4MP0004957_abnormal_blastocyst_morpholog4.68873636
5MP0008057_abnormal_DNA_replication4.38067934
6MP0003077_abnormal_cell_cycle4.30569601
7MP0008058_abnormal_DNA_repair3.81273438
8MP0008932_abnormal_embryonic_tissue3.04482584
9MP0008007_abnormal_cellular_replicative2.93176125
10MP0003123_paternal_imprinting2.89154152
11MP0001730_embryonic_growth_arrest2.51465826
12MP0003718_maternal_effect2.36736214
13MP0008877_abnormal_DNA_methylation2.28321734
14MP0000350_abnormal_cell_proliferation2.26952631
15MP0003786_premature_aging2.25757065
16MP0002396_abnormal_hematopoietic_system1.92811030
17MP0005380_embryogenesis_phenotype1.85451720
18MP0001672_abnormal_embryogenesis/_devel1.85451720
19MP0001697_abnormal_embryo_size1.78560418
20MP0003806_abnormal_nucleotide_metabolis1.71251074
21MP0010030_abnormal_orbit_morphology1.67102769
22MP0003984_embryonic_growth_retardation1.62926047
23MP0006292_abnormal_olfactory_placode1.61135232
24MP0002085_abnormal_embryonic_tissue1.61085377
25MP0000569_abnormal_digit_pigmentation1.59974586
26MP0002080_prenatal_lethality1.59944803
27MP0002088_abnormal_embryonic_growth/wei1.58549661
28MP0010352_gastrointestinal_tract_polyps1.58282063
29MP0010307_abnormal_tumor_latency1.56112661
30MP0003315_abnormal_perineum_morphology1.53960011
31MP0000372_irregular_coat_pigmentation1.53714547
32MP0003121_genomic_imprinting1.53615004
33MP0003890_abnormal_embryonic-extraembry1.52027921
34MP0006072_abnormal_retinal_apoptosis1.43033049
35MP0002210_abnormal_sex_determination1.42923858
36MP0002084_abnormal_developmental_patter1.42209606
37MP0000313_abnormal_cell_death1.40986056
38MP0001293_anophthalmia1.39897355
39MP0002254_reproductive_system_inflammat1.38965584
40MP0004197_abnormal_fetal_growth/weight/1.36693790
41MP0002234_abnormal_pharynx_morphology1.34668560
42MP0003567_abnormal_fetal_cardiomyocyte1.33984997
43MP0003941_abnormal_skin_development1.33217934
44MP0002086_abnormal_extraembryonic_tissu1.32819165
45MP0000490_abnormal_crypts_of1.28266429
46MP0003195_calcinosis1.27181941
47MP0004147_increased_porphyrin_level1.27032857
48MP0002009_preneoplasia1.25062116
49MP0001145_abnormal_male_reproductive1.23145283
50MP0002019_abnormal_tumor_incidence1.21628973
51MP0002160_abnormal_reproductive_system1.15386060
52MP0003119_abnormal_digestive_system1.13868808
53MP0001929_abnormal_gametogenesis1.13867316
54MP0000653_abnormal_sex_gland1.09468884
55MP0002837_dystrophic_cardiac_calcinosis1.08095351
56MP0002697_abnormal_eye_size1.07450182
57MP0004133_heterotaxia1.06879599
58MP0000647_abnormal_sebaceous_gland1.04440963
59MP0001661_extended_life_span1.04401671
60MP0009379_abnormal_foot_pigmentation1.03595323
61MP0000537_abnormal_urethra_morphology1.03419127
62MP0000631_abnormal_neuroendocrine_gland1.02522865
63MP0009053_abnormal_anal_canal1.00529765
64MP0003186_abnormal_redox_activity0.99833300
65MP0002163_abnormal_gland_morphology0.97698365
66MP0001346_abnormal_lacrimal_gland0.97425605
67MP0002233_abnormal_nose_morphology0.96968225
68MP0003937_abnormal_limbs/digits/tail_de0.96763734
69MP0009333_abnormal_splenocyte_physiolog0.95680396
70MP0001119_abnormal_female_reproductive0.94655191
71MP0002102_abnormal_ear_morphology0.92451492
72MP0005187_abnormal_penis_morphology0.92339847
73MP0000358_abnormal_cell_content/0.92046755
74MP0005389_reproductive_system_phenotype0.91133126
75MP0005253_abnormal_eye_physiology0.90730016
76MP0002653_abnormal_ependyma_morphology0.90478851
77MP0000427_abnormal_hair_cycle0.90053658
78MP0000566_synostosis0.89594735
79MP0003646_muscle_fatigue0.89050367
80MP0005645_abnormal_hypothalamus_physiol0.86609704
81MP0002132_abnormal_respiratory_system0.86211584
82MP0004808_abnormal_hematopoietic_stem0.85915811
83MP0003136_yellow_coat_color0.85698834
84MP0009672_abnormal_birth_weight0.85249014
85MP0003943_abnormal_hepatobiliary_system0.84157338
86MP0002938_white_spotting0.83619927
87MP0005408_hypopigmentation0.82731997
88MP0001286_abnormal_eye_development0.82730138
89MP0008995_early_reproductive_senescence0.82154072
90MP0008789_abnormal_olfactory_epithelium0.81859564
91MP0003221_abnormal_cardiomyocyte_apopto0.81774047
92MP0005174_abnormal_tail_pigmentation0.81441023
93MP0002111_abnormal_tail_morphology0.80709771
94MP0003950_abnormal_plasma_membrane0.79747401
95MP0005391_vision/eye_phenotype0.79206925
96MP0001529_abnormal_vocalization0.76898079
97MP0005384_cellular_phenotype0.75549112
98MP0003755_abnormal_palate_morphology0.75241972
99MP0005075_abnormal_melanosome_morpholog0.73931874
100MP0003787_abnormal_imprinting0.73873780
101MP0006035_abnormal_mitochondrial_morpho0.73103582
102MP0003861_abnormal_nervous_system0.72095005
103MP0006036_abnormal_mitochondrial_physio0.69757421
104MP0004215_abnormal_myocardial_fiber0.68821551
105MP0002095_abnormal_skin_pigmentation0.68695165
106MP0000703_abnormal_thymus_morphology0.67096137
107MP0000428_abnormal_craniofacial_morphol0.65634486
108MP0000516_abnormal_urinary_system0.65257485
109MP0005367_renal/urinary_system_phenotyp0.65257485
110MP0003935_abnormal_craniofacial_develop0.65249422
111MP0009697_abnormal_copulation0.65045781
112MP0009703_decreased_birth_body0.64935748
113MP0005551_abnormal_eye_electrophysiolog0.64386361
114MP0005395_other_phenotype0.64213101
115MP0005621_abnormal_cell_physiology0.63866257
116MP0008260_abnormal_autophagy0.63788291
117MP0005266_abnormal_metabolism0.63779113
118MP0002277_abnormal_respiratory_mucosa0.61648324
119MP0005397_hematopoietic_system_phenotyp0.61216285
120MP0001545_abnormal_hematopoietic_system0.61216285
121MP0005076_abnormal_cell_differentiation0.60449859
122MP0003698_abnormal_male_reproductive0.60276409
123MP0000750_abnormal_muscle_regeneration0.59932430
124MP0001919_abnormal_reproductive_system0.59200841
125MP0003115_abnormal_respiratory_system0.58367315
126MP0002161_abnormal_fertility/fecundity0.57910982
127MP0003936_abnormal_reproductive_system0.57675211
128MP0003699_abnormal_female_reproductive0.57408016
129MP0005023_abnormal_wound_healing0.57112440
130MP0005394_taste/olfaction_phenotype0.57011557
131MP0005499_abnormal_olfactory_system0.57011557
132MP0002751_abnormal_autonomic_nervous0.56629905
133MP0001186_pigmentation_phenotype0.56609394
134MP0002092_abnormal_eye_morphology0.56389412
135MP0002722_abnormal_immune_system0.55413922
136MP0000858_altered_metastatic_potential0.53678770
137MP0000049_abnormal_middle_ear0.53348759

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.62997538
2Breast hypoplasia (HP:0003187)4.78483542
3Chromsome breakage (HP:0040012)4.00619020
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97943786
5Reticulocytopenia (HP:0001896)3.91419430
6Oral leukoplakia (HP:0002745)3.76340588
7Colon cancer (HP:0003003)3.74189095
8Patellar aplasia (HP:0006443)3.63582823
9Carpal bone hypoplasia (HP:0001498)3.52673300
10Abnormality of cells of the erythroid lineage (HP:0012130)3.51387769
11Meckel diverticulum (HP:0002245)3.47202503
12Cerebral hypomyelination (HP:0006808)3.40977432
13Aplasia/Hypoplasia of the patella (HP:0006498)3.40809143
14Abnormality of the preputium (HP:0100587)3.36339784
15Medulloblastoma (HP:0002885)3.34900550
16Selective tooth agenesis (HP:0001592)3.32338463
17Rough bone trabeculation (HP:0100670)3.29424280
18Impulsivity (HP:0100710)3.28968788
19Abnormality of the ileum (HP:0001549)3.28839620
20Abnormal number of erythroid precursors (HP:0012131)3.27275373
21Abnormality of chromosome stability (HP:0003220)3.22718668
22Degeneration of anterior horn cells (HP:0002398)3.13817938
23Abnormality of the anterior horn cell (HP:0006802)3.13817938
24Aplastic anemia (HP:0001915)3.07782699
25Absent radius (HP:0003974)3.07204875
26Volvulus (HP:0002580)3.05301521
27Aplasia/Hypoplasia of the uvula (HP:0010293)3.01671742
28Abnormality of the labia minora (HP:0012880)2.94604393
29Ependymoma (HP:0002888)2.88614765
30Aplasia involving forearm bones (HP:0009822)2.86147664
31Absent forearm bone (HP:0003953)2.86147664
32Supernumerary spleens (HP:0009799)2.82916584
33Absent thumb (HP:0009777)2.80294224
34Small intestinal stenosis (HP:0012848)2.79824384
35Duodenal stenosis (HP:0100867)2.79824384
36Macrocytic anemia (HP:0001972)2.69498309
37Abnormal lung lobation (HP:0002101)2.65082963
38Agnosia (HP:0010524)2.64633230
39Premature graying of hair (HP:0002216)2.56542287
40Horseshoe kidney (HP:0000085)2.55208206
41Bone marrow hypocellularity (HP:0005528)2.51705245
42Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.47107376
43Rhabdomyosarcoma (HP:0002859)2.45707970
44Myelodysplasia (HP:0002863)2.43453404
45Premature ovarian failure (HP:0008209)2.43078353
46Neoplasm of the pancreas (HP:0002894)2.42607419
47Multiple enchondromatosis (HP:0005701)2.41316041
48Pancreatic cysts (HP:0001737)2.39074306
49Abnormal number of incisors (HP:0011064)2.38774555
50Abnormal trabecular bone morphology (HP:0100671)2.37971165
51Trismus (HP:0000211)2.37066354
5211 pairs of ribs (HP:0000878)2.36452910
53Microretrognathia (HP:0000308)2.34809191
54Triphalangeal thumb (HP:0001199)2.33658021
55Neoplasm of the adrenal cortex (HP:0100641)2.32109980
56Clubbing of toes (HP:0100760)2.31828318
57Secondary amenorrhea (HP:0000869)2.31553046
58Sloping forehead (HP:0000340)2.30176815
59Abnormality of the duodenum (HP:0002246)2.28266329
60Astrocytoma (HP:0009592)2.27945784
61Abnormality of the astrocytes (HP:0100707)2.27945784
62Ectopic kidney (HP:0000086)2.26273267
63Pallor (HP:0000980)2.26111425
64Abnormality of methionine metabolism (HP:0010901)2.24930581
65Tracheoesophageal fistula (HP:0002575)2.24475612
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.21022311
67Increased nuchal translucency (HP:0010880)2.21017108
68Atresia of the external auditory canal (HP:0000413)2.20194107
69Pancreatic islet-cell hyperplasia (HP:0004510)2.20156913
70Pancreatic fibrosis (HP:0100732)2.15176507
71Cellular immunodeficiency (HP:0005374)2.14906532
72Cleft eyelid (HP:0000625)2.14031356
73Short thumb (HP:0009778)2.11917297
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09781311
75Intestinal atresia (HP:0011100)2.09528761
76Duplicated collecting system (HP:0000081)2.05768326
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03547412
78Neoplasm of the adrenal gland (HP:0100631)2.03464590
79Hypoplasia of the radius (HP:0002984)2.03040332
80Glossoptosis (HP:0000162)2.01538064
81Facial cleft (HP:0002006)2.01429504
82Stenosis of the external auditory canal (HP:0000402)2.01403809
83Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99118734
84Hyperalaninemia (HP:0003348)1.98514487
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98514487
86Abnormality of alanine metabolism (HP:0010916)1.98514487
87Squamous cell carcinoma (HP:0002860)1.97082420
88Bilateral microphthalmos (HP:0007633)1.96723767
89Ureteral duplication (HP:0000073)1.95368540
90Abnormality of the umbilical cord (HP:0010881)1.95236200
91Abnormality of DNA repair (HP:0003254)1.94057903
92CNS hypomyelination (HP:0003429)1.92885916
93Abnormality of the carotid arteries (HP:0005344)1.92160574
94Abnormality of homocysteine metabolism (HP:0010919)1.92104642
95Homocystinuria (HP:0002156)1.92104642
96Abnormality of the pons (HP:0007361)1.91693313
97Megaloblastic anemia (HP:0001889)1.90726750
98Hypoplasia of the pons (HP:0012110)1.90621427
99Increased hepatocellular lipid droplets (HP:0006565)1.89420752
100Nephroblastoma (Wilms tumor) (HP:0002667)1.89118339
101Neoplasm of the colon (HP:0100273)1.88078256
102Abnormality of the fetal cardiovascular system (HP:0010948)1.87682285
103Abnormal umbilical cord blood vessels (HP:0011403)1.87682285
104Single umbilical artery (HP:0001195)1.87682285
105Glioma (HP:0009733)1.87447400
106Methylmalonic acidemia (HP:0002912)1.86048750
107Irregular epiphyses (HP:0010582)1.85652040
108Breast aplasia (HP:0100783)1.84870607
109Abnormality of serum amino acid levels (HP:0003112)1.84819274
110Acute encephalopathy (HP:0006846)1.84716773
111Aplasia/hypoplasia of the humerus (HP:0006507)1.83742700
112Proximal placement of thumb (HP:0009623)1.83624265
113Pancytopenia (HP:0001876)1.82991570
114Dandy-Walker malformation (HP:0001305)1.81920918
115Aplasia/Hypoplasia of the breasts (HP:0010311)1.81307185
116Gastrointestinal atresia (HP:0002589)1.80687444
117Deviation of the thumb (HP:0009603)1.80525328
118Missing ribs (HP:0000921)1.80432569
119Abnormal spermatogenesis (HP:0008669)1.79937672
120Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79056932
121Abnormality of midbrain morphology (HP:0002418)1.78528981
122Molar tooth sign on MRI (HP:0002419)1.78528981
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.78417536
124Sparse eyelashes (HP:0000653)1.78334309
125Embryonal renal neoplasm (HP:0011794)1.77502042
126Microvesicular hepatic steatosis (HP:0001414)1.76887522
127Basal cell carcinoma (HP:0002671)1.76382778
128Abnormality of the renal collecting system (HP:0004742)1.76176826
129Breast carcinoma (HP:0003002)1.75704817
130Slender long bone (HP:0003100)1.75398659
131Cortical dysplasia (HP:0002539)1.74601072
132Cafe-au-lait spot (HP:0000957)1.74322444
133Bifid tongue (HP:0010297)1.73914806
134Lipid accumulation in hepatocytes (HP:0006561)1.73579589
135Limb hypertonia (HP:0002509)1.71995736
136Small hand (HP:0200055)1.71453296
137Increased CSF lactate (HP:0002490)1.70717249
138Choanal atresia (HP:0000453)1.70672933
139Preaxial hand polydactyly (HP:0001177)1.70433741
140Abnormality of glycolysis (HP:0004366)1.70338877
141Arteriovenous malformation (HP:0100026)1.70329773
142Acute necrotizing encephalopathy (HP:0006965)1.66553917
143Hyperglycinemia (HP:0002154)1.66118705
144Abnormality of the renal cortex (HP:0011035)1.65068055
145Nephronophthisis (HP:0000090)1.64636292
146Hypothermia (HP:0002045)1.64433637
147Esophageal atresia (HP:0002032)1.63089123
148Type I transferrin isoform profile (HP:0003642)1.62543350
149Abnormal biliary tract physiology (HP:0012439)1.62525090
150Bile duct proliferation (HP:0001408)1.62525090
151Ovarian neoplasm (HP:0100615)1.61715720
152Embryonal neoplasm (HP:0002898)1.61245595
153Hyperglycinuria (HP:0003108)1.61109261
154Neoplasm of the oral cavity (HP:0100649)1.61028378
155Increased serum lactate (HP:0002151)1.59778006
156Neoplasm of striated muscle (HP:0009728)1.59050795
157Meningioma (HP:0002858)1.57391642
158Abnormality of cochlea (HP:0000375)1.57245462
159Increased serum pyruvate (HP:0003542)1.55749259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.94501065
2WEE14.56541077
3CDC74.05003658
4EIF2AK13.57801054
5SRPK12.85331929
6PLK42.71391150
7TTK2.57332895
8BRSK22.52948236
9NEK12.47169083
10NEK22.44055012
11ACVR1B2.43839435
12TSSK62.39855251
13FRK2.26361203
14PLK12.15859775
15NME22.15760297
16EIF2AK32.13213036
17NUAK12.11043399
18CDK192.10476896
19PLK32.09268810
20STK162.05369922
21VRK12.04447477
22VRK21.96583902
23MKNK11.84207324
24TAF11.83137753
25WNK31.71328623
26TRIM281.69798999
27BMPR1B1.68842012
28AURKB1.65842414
29CDK71.63224595
30ATR1.62857583
31TLK11.60525718
32BRSK11.60099396
33CHEK21.59670293
34ZAK1.53603065
35MKNK21.50867580
36DYRK31.48651224
37AURKA1.44859874
38TNIK1.42452902
39PASK1.41484598
40CCNB11.35243011
41RPS6KB21.32665140
42EPHA21.29621516
43STK38L1.26752683
44TESK21.23613969
45CHEK11.19496717
46MAP3K81.13767546
47STK41.12188890
48FGFR21.10844512
49CDK41.09695288
50RPS6KA41.07075259
51ERBB30.98181667
52EIF2AK20.95097104
53PLK20.94799887
54STK390.91866813
55TGFBR10.90148668
56MAP3K100.89360240
57ATM0.86561966
58PBK0.84821928
59PNCK0.84454777
60CDK20.82503170
61BRAF0.80786859
62WNK40.77437364
63PAK40.76781527
64STK100.76072218
65FGFR10.75924463
66CLK10.73766010
67GRK10.72991195
68CSNK2A10.72804974
69CSNK2A20.72643390
70NME10.71371500
71AKT30.69957307
72LATS20.69273638
73PRKCI0.68504713
74PDK40.67808037
75PDK30.67808037
76MAP3K40.66374877
77OXSR10.66282631
78CDK10.64747772
79ERBB40.64529581
80DYRK20.63562215
81PAK10.61734326
82CDK120.61310184
83PIM10.61231380
84SCYL20.60383080
85MELK0.59574325
86CDK80.59018576
87NLK0.57769330
88MAP4K20.56820989
89PIM20.56549195
90STK30.55989139
91TESK10.52958413
92MAPKAPK30.52726515
93ADRBK20.52217884
94ALK0.50188955
95EEF2K0.43983878
96MAPKAPK50.43597110
97INSRR0.42321466
98CSNK1E0.40616924
99TAOK20.39318414
100MAP2K30.38859611
101BCKDK0.38580865
102STK240.38129451
103KDR0.37508728
104CAMK1G0.36759412
105PDK20.36461838
106CSNK1G20.35987843
107BRD40.35855503
108RPS6KA50.35594034
109CSNK1A1L0.33669839
110MST40.33019492
111FER0.32130121
112CDK30.31447412
113ABL20.31247882
114PRKDC0.30454201
115CDK60.30124395
116CSNK1G30.29820164
117CAMK1D0.28689758
118NEK90.27774760
119FLT30.27213178
120LIMK10.25848764
121TAOK30.25746943
122YES10.25679755
123TIE10.24852360
124AKT20.24311036
125LRRK20.24249377
126MAPK130.23643099
127CDK11A0.22781000
128MARK30.21192648
129LATS10.21060191
130MAP2K60.20291176
131BCR0.17434135
132MAPK140.17077302
133MAP3K110.15646184
134CSNK1G10.15426651

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.90245744
2Mismatch repair_Homo sapiens_hsa034304.36448118
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.01886964
4Proteasome_Homo sapiens_hsa030503.81566062
5RNA polymerase_Homo sapiens_hsa030203.80124607
6Ribosome_Homo sapiens_hsa030103.51294750
7Spliceosome_Homo sapiens_hsa030403.35326410
8* RNA transport_Homo sapiens_hsa030133.25099277
9Homologous recombination_Homo sapiens_hsa034403.05763726
10Nucleotide excision repair_Homo sapiens_hsa034202.94148931
11Base excision repair_Homo sapiens_hsa034102.93383945
12Cell cycle_Homo sapiens_hsa041102.76078262
13Pyrimidine metabolism_Homo sapiens_hsa002402.73408998
14One carbon pool by folate_Homo sapiens_hsa006702.47379187
15Fanconi anemia pathway_Homo sapiens_hsa034602.40999921
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38700999
17Basal transcription factors_Homo sapiens_hsa030222.15950246
18RNA degradation_Homo sapiens_hsa030182.02188138
19Non-homologous end-joining_Homo sapiens_hsa034502.00201001
20Propanoate metabolism_Homo sapiens_hsa006401.80039450
21mRNA surveillance pathway_Homo sapiens_hsa030151.67371344
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65734289
23p53 signaling pathway_Homo sapiens_hsa041151.57026854
24Purine metabolism_Homo sapiens_hsa002301.54928267
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38998473
26Steroid biosynthesis_Homo sapiens_hsa001001.38006664
27Vitamin B6 metabolism_Homo sapiens_hsa007501.32381498
28Pyruvate metabolism_Homo sapiens_hsa006201.28844961
29Epstein-Barr virus infection_Homo sapiens_hsa051691.18916373
30Oocyte meiosis_Homo sapiens_hsa041141.07285909
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.06954218
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01728245
33Fatty acid elongation_Homo sapiens_hsa000621.00779027
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00629556
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97280204
36Systemic lupus erythematosus_Homo sapiens_hsa053220.95639905
37Nitrogen metabolism_Homo sapiens_hsa009100.95303987
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94770288
39Butanoate metabolism_Homo sapiens_hsa006500.94109936
40Biosynthesis of amino acids_Homo sapiens_hsa012300.94026933
41Huntingtons disease_Homo sapiens_hsa050160.93008516
42Folate biosynthesis_Homo sapiens_hsa007900.89424665
43Lysine degradation_Homo sapiens_hsa003100.88219180
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84326905
45Protein export_Homo sapiens_hsa030600.83631114
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.81490862
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.80516267
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.79830027
49Parkinsons disease_Homo sapiens_hsa050120.78210542
50Pentose phosphate pathway_Homo sapiens_hsa000300.77001270
51Glutathione metabolism_Homo sapiens_hsa004800.71332573
52Viral carcinogenesis_Homo sapiens_hsa052030.68691087
53Herpes simplex infection_Homo sapiens_hsa051680.67066624
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66026429
55Sulfur relay system_Homo sapiens_hsa041220.64672111
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63733819
57Phototransduction_Homo sapiens_hsa047440.61997247
58Selenocompound metabolism_Homo sapiens_hsa004500.61950860
59Oxidative phosphorylation_Homo sapiens_hsa001900.60395107
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60284510
61Fatty acid metabolism_Homo sapiens_hsa012120.59974468
62Peroxisome_Homo sapiens_hsa041460.56922556
63Carbon metabolism_Homo sapiens_hsa012000.56152002
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55561538
65Antigen processing and presentation_Homo sapiens_hsa046120.54917150
66HTLV-I infection_Homo sapiens_hsa051660.53694780
67Tryptophan metabolism_Homo sapiens_hsa003800.53033486
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51868136
69Renin-angiotensin system_Homo sapiens_hsa046140.50010279
70Caffeine metabolism_Homo sapiens_hsa002320.47831052
71Fructose and mannose metabolism_Homo sapiens_hsa000510.46029317
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44398896
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41033062
74MicroRNAs in cancer_Homo sapiens_hsa052060.40475614
75TGF-beta signaling pathway_Homo sapiens_hsa043500.38877012
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38744779
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38244116
78Thyroid cancer_Homo sapiens_hsa052160.37863909
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37860557
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37168583
81Ether lipid metabolism_Homo sapiens_hsa005650.36053292
82Metabolic pathways_Homo sapiens_hsa011000.35034963
83Hippo signaling pathway_Homo sapiens_hsa043900.34130375
84Fatty acid degradation_Homo sapiens_hsa000710.33164359
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33054755
86Basal cell carcinoma_Homo sapiens_hsa052170.32784700
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32232599
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31548121
89Sulfur metabolism_Homo sapiens_hsa009200.30574714
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30193194
91Small cell lung cancer_Homo sapiens_hsa052220.29843596
92Legionellosis_Homo sapiens_hsa051340.29171558
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28340656
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25312855
95Galactose metabolism_Homo sapiens_hsa000520.25262238
96Arachidonic acid metabolism_Homo sapiens_hsa005900.25155824
97Alcoholism_Homo sapiens_hsa050340.22254565
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22059763
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21242440
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20415102
101Regulation of autophagy_Homo sapiens_hsa041400.19101919
102Taste transduction_Homo sapiens_hsa047420.18840374
103Olfactory transduction_Homo sapiens_hsa047400.18715642
104Hedgehog signaling pathway_Homo sapiens_hsa043400.18037321
105Fatty acid biosynthesis_Homo sapiens_hsa000610.17449621
106Alzheimers disease_Homo sapiens_hsa050100.16974999
107N-Glycan biosynthesis_Homo sapiens_hsa005100.16489243
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15062630
109Colorectal cancer_Homo sapiens_hsa052100.14351193
110Apoptosis_Homo sapiens_hsa042100.14284270
111HIF-1 signaling pathway_Homo sapiens_hsa040660.12535015
112Arginine and proline metabolism_Homo sapiens_hsa003300.12453575
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10436367
114Linoleic acid metabolism_Homo sapiens_hsa005910.09763215
115Pathways in cancer_Homo sapiens_hsa052000.08377669
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06541142
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06277162
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05832467
119Bladder cancer_Homo sapiens_hsa052190.05065102
120Vitamin digestion and absorption_Homo sapiens_hsa049770.04496169
121Tight junction_Homo sapiens_hsa045300.02070138
122Notch signaling pathway_Homo sapiens_hsa043300.02015890
123Wnt signaling pathway_Homo sapiens_hsa043100.01952482
124Hepatitis B_Homo sapiens_hsa051610.01622673
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.01110185
126Primary immunodeficiency_Homo sapiens_hsa05340-0.0135026
127Adherens junction_Homo sapiens_hsa04520-0.0127531
128Influenza A_Homo sapiens_hsa05164-0.0029990

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