NUP160

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.47952673
2nuclear pore complex assembly (GO:0051292)5.44167393
3protein localization to kinetochore (GO:0034501)5.27193955
4DNA unwinding involved in DNA replication (GO:0006268)4.86685996
5double-strand break repair via nonhomologous end joining (GO:0006303)4.47513191
6non-recombinational repair (GO:0000726)4.47513191
7DNA replication initiation (GO:0006270)4.47373340
8establishment of integrated proviral latency (GO:0075713)4.43947571
9* mitotic nuclear envelope disassembly (GO:0007077)4.43422800
10protein localization to chromosome, centromeric region (GO:0071459)4.38355911
11mitotic sister chromatid cohesion (GO:0007064)4.28510566
12mitotic metaphase plate congression (GO:0007080)4.26875296
13DNA strand elongation involved in DNA replication (GO:0006271)4.20564978
14pore complex assembly (GO:0046931)4.19728810
15DNA replication-dependent nucleosome assembly (GO:0006335)4.10927251
16DNA replication-dependent nucleosome organization (GO:0034723)4.10927251
17* nuclear envelope disassembly (GO:0051081)4.10796995
18* membrane disassembly (GO:0030397)4.10796995
19IMP biosynthetic process (GO:0006188)4.06743470
20DNA strand elongation (GO:0022616)4.05107293
21DNA topological change (GO:0006265)4.03182067
22mitotic chromosome condensation (GO:0007076)3.95659139
23mitotic sister chromatid segregation (GO:0000070)3.89753253
24telomere maintenance via semi-conservative replication (GO:0032201)3.86196866
25folic acid-containing compound biosynthetic process (GO:0009396)3.83146383
26nucleobase biosynthetic process (GO:0046112)3.83022513
27sister chromatid segregation (GO:0000819)3.82148663
28kinetochore organization (GO:0051383)3.81614270
29metaphase plate congression (GO:0051310)3.80630517
30DNA replication checkpoint (GO:0000076)3.80127571
31DNA geometric change (GO:0032392)3.77836580
32DNA duplex unwinding (GO:0032508)3.77132058
33regulation of histone H3-K9 methylation (GO:0051570)3.74613440
34regulation of spindle organization (GO:0090224)3.71412491
35chromatin remodeling at centromere (GO:0031055)3.70808839
36positive regulation of chromosome segregation (GO:0051984)3.70420754
37CENP-A containing nucleosome assembly (GO:0034080)3.67817399
38DNA ligation (GO:0006266)3.67391902
39mitotic recombination (GO:0006312)3.66082180
40telomere maintenance via recombination (GO:0000722)3.61195096
41IMP metabolic process (GO:0046040)3.55642089
42DNA replication-independent nucleosome assembly (GO:0006336)3.54970140
43DNA replication-independent nucleosome organization (GO:0034724)3.54970140
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53918568
45attachment of spindle microtubules to kinetochore (GO:0008608)3.53241735
46establishment of viral latency (GO:0019043)3.52221298
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51711023
48pre-miRNA processing (GO:0031054)3.51292880
49purine nucleobase biosynthetic process (GO:0009113)3.49763149
50negative regulation of histone methylation (GO:0031061)3.48107863
51establishment of chromosome localization (GO:0051303)3.45909114
52regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45542391
53meiotic chromosome segregation (GO:0045132)3.44226444
54protein localization to chromosome (GO:0034502)3.44039856
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.43535870
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.43535870
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.43535870
58regulation of helicase activity (GO:0051095)3.43188775
59DNA double-strand break processing (GO:0000729)3.41813297
60regulation of mitotic spindle organization (GO:0060236)3.40371511
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.35392711
62regulation of centrosome duplication (GO:0010824)3.34812843
63DNA strand renaturation (GO:0000733)3.33855845
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.32505494
65chromosome condensation (GO:0030261)3.28992503
66telomere maintenance via telomere lengthening (GO:0010833)3.28925075
67ribosome assembly (GO:0042255)3.28661702
68formation of translation preinitiation complex (GO:0001731)3.27983994
69somatic hypermutation of immunoglobulin genes (GO:0016446)3.27522864
70somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27522864
71regulation of centrosome cycle (GO:0046605)3.26783802
72regulation of RNA export from nucleus (GO:0046831)3.26519753
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.23749529
74histone exchange (GO:0043486)3.23483682
75regulation of mitotic sister chromatid separation (GO:0010965)3.22974713
76chromatin assembly or disassembly (GO:0006333)3.21939372
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21445724
78spindle checkpoint (GO:0031577)3.21017430
79kinetochore assembly (GO:0051382)3.19466369
80negative regulation of mRNA processing (GO:0050686)3.19141784
81regulation of chromosome segregation (GO:0051983)3.18809492
82DNA conformation change (GO:0071103)3.15658881
83protein complex localization (GO:0031503)3.15346639
84replication fork processing (GO:0031297)3.14330874
85* nuclear envelope organization (GO:0006998)3.11813868
86regulation of centriole replication (GO:0046599)3.11799032
87mismatch repair (GO:0006298)3.11652950
88protein K6-linked ubiquitination (GO:0085020)3.11557655
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11299618
90regulation of sister chromatid cohesion (GO:0007063)3.10730334
91telomere maintenance (GO:0000723)3.09044930
92somatic cell DNA recombination (GO:0016444)3.08475462
93somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.08475462
94negative regulation of DNA recombination (GO:0045910)3.08389149
95negative regulation of chromosome segregation (GO:0051985)3.07850150
96somatic recombination of immunoglobulin gene segments (GO:0016447)3.07764129
97telomere organization (GO:0032200)3.07743355
98negative regulation of mRNA metabolic process (GO:1903312)3.07622097
99chromatin assembly (GO:0031497)3.05984173
100mitotic spindle checkpoint (GO:0071174)3.05867457
101regulation of gene silencing by RNA (GO:0060966)3.05561153
102regulation of posttranscriptional gene silencing (GO:0060147)3.05561153
103regulation of gene silencing by miRNA (GO:0060964)3.05561153
104regulation of telomere maintenance via telomerase (GO:0032210)3.05319864
105viral mRNA export from host cell nucleus (GO:0046784)3.04526859
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04410383
107spindle assembly checkpoint (GO:0071173)3.04337797
108negative regulation of mitotic sister chromatid separation (GO:2000816)3.01766332
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01766332
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01766332
111negative regulation of sister chromatid segregation (GO:0033046)3.01766332
112chromosome segregation (GO:0007059)3.01560589
113ribosome biogenesis (GO:0042254)3.01068904
114regulation of translational fidelity (GO:0006450)3.00928351
115heterochromatin organization (GO:0070828)2.98388036
116regulation of DNA endoreduplication (GO:0032875)2.98335022
117maturation of SSU-rRNA (GO:0030490)2.97888647
118ATP-dependent chromatin remodeling (GO:0043044)2.96862150
119mitotic spindle assembly checkpoint (GO:0007094)2.96594194
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.95865910
121dosage compensation (GO:0007549)2.95605027
122regulation of sister chromatid segregation (GO:0033045)2.95026316
123regulation of mitotic sister chromatid segregation (GO:0033047)2.95026316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.22944738
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.34728985
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.81245684
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39668478
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.87443346
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76850300
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74900813
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59085219
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56793268
10AR_21909140_ChIP-Seq_LNCAP_Human2.39847313
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.36858113
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25799102
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20196644
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.17336213
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14290069
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07766390
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07104090
18E2F7_22180533_ChIP-Seq_HELA_Human10.9217633
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.98710252
20XRN2_22483619_ChIP-Seq_HELA_Human1.93308004
21MYC_22102868_ChIP-Seq_BL_Human1.93108405
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.91337696
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88718342
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88142567
25VDR_23849224_ChIP-Seq_CD4+_Human1.86048359
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86007722
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75758499
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.74440852
29FOXP3_21729870_ChIP-Seq_TREG_Human1.72153087
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71931215
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67876751
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67342976
33* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67119010
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66794188
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.65027150
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59877048
37CIITA_25753668_ChIP-Seq_RAJI_Human1.58894541
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52250796
39ELK1_19687146_ChIP-ChIP_HELA_Human1.52136144
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51915860
41TTF2_22483619_ChIP-Seq_HELA_Human1.46546904
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46275555
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45494200
44KDM5A_27292631_Chip-Seq_BREAST_Human1.43013824
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42360749
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41594546
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40968092
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39239034
49DCP1A_22483619_ChIP-Seq_HELA_Human1.37776145
50* GABP_19822575_ChIP-Seq_HepG2_Human1.37702332
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35193201
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33697336
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31865389
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31456787
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31440389
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23394604
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21190072
58TFEB_21752829_ChIP-Seq_HELA_Human1.18249834
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17104725
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16401102
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16210319
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15032862
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15032299
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11159049
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10292519
66EWS_26573619_Chip-Seq_HEK293_Human1.10102697
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09571933
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08976247
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.08918482
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.07957499
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07123025
72FUS_26573619_Chip-Seq_HEK293_Human1.06826270
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05783816
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05320632
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05046244
76* SOX2_16153702_ChIP-ChIP_HESCs_Human1.04976531
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03463895
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00847170
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.00673517
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99730827
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99730827
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99730827
83TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98630551
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.98512529
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98019540
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95943956
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95794958
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94330966
89* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94026416
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93460271
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93118831
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92774218
93VDR_21846776_ChIP-Seq_THP-1_Human0.90757421
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90004334
95TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89906491
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.89669057
97IRF1_19129219_ChIP-ChIP_H3396_Human0.89606441
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88172863
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86948709
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86652613
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86340301
102CHD1_26751641_Chip-Seq_LNCaP_Human0.85910837
103* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84263466
104MYC_18940864_ChIP-ChIP_HL60_Human0.83669710
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83271611
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83101523
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82594549
108* SPI1_23547873_ChIP-Seq_NB4_Human0.82527756
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82261454
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81137656
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80147321
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78139138
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72768484
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71989688
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69872759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.78166688
2MP0008057_abnormal_DNA_replication4.56520408
3MP0003693_abnormal_embryo_hatching4.44387270
4MP0003111_abnormal_nucleus_morphology4.30320435
5MP0003077_abnormal_cell_cycle3.86076672
6MP0004957_abnormal_blastocyst_morpholog3.78868953
7MP0008058_abnormal_DNA_repair3.09922658
8MP0010352_gastrointestinal_tract_polyps2.95850487
9MP0008007_abnormal_cellular_replicative2.67222149
10MP0002396_abnormal_hematopoietic_system2.62804264
11MP0009697_abnormal_copulation2.57271333
12MP0010307_abnormal_tumor_latency2.40941360
13MP0001730_embryonic_growth_arrest2.36370168
14MP0000350_abnormal_cell_proliferation2.34339501
15MP0003123_paternal_imprinting2.28019287
16MP0008932_abnormal_embryonic_tissue2.20023957
17MP0002009_preneoplasia2.13680531
18MP0008877_abnormal_DNA_methylation2.02593372
19MP0005380_embryogenesis_phenotype1.90586092
20MP0001672_abnormal_embryogenesis/_devel1.90586092
21MP0003786_premature_aging1.79073046
22MP0005076_abnormal_cell_differentiation1.77456525
23MP0001697_abnormal_embryo_size1.77096863
24MP0003121_genomic_imprinting1.74023693
25MP0003984_embryonic_growth_retardation1.72744383
26MP0002084_abnormal_developmental_patter1.70706185
27MP0002088_abnormal_embryonic_growth/wei1.69631186
28MP0004808_abnormal_hematopoietic_stem1.68922523
29MP0002085_abnormal_embryonic_tissue1.66096541
30MP0004197_abnormal_fetal_growth/weight/1.65076750
31MP0002086_abnormal_extraembryonic_tissu1.63750314
32MP0003890_abnormal_embryonic-extraembry1.61139611
33MP0000490_abnormal_crypts_of1.59597981
34MP0002080_prenatal_lethality1.56469761
35MP0001293_anophthalmia1.40954717
36MP0002019_abnormal_tumor_incidence1.40025538
37MP0000313_abnormal_cell_death1.39087298
38MP0003567_abnormal_fetal_cardiomyocyte1.38888627
39MP0003763_abnormal_thymus_physiology1.34518800
40MP0000703_abnormal_thymus_morphology1.26895702
41MP0002398_abnormal_bone_marrow1.20447798
42MP0006035_abnormal_mitochondrial_morpho1.19723617
43MP0008995_early_reproductive_senescence1.19510023
44MP0005397_hematopoietic_system_phenotyp1.18982094
45MP0001545_abnormal_hematopoietic_system1.18982094
46MP0002210_abnormal_sex_determination1.12924821
47MP0005075_abnormal_melanosome_morpholog1.11792898
48MP0005408_hypopigmentation1.10091460
49MP0002938_white_spotting1.09722661
50MP0003221_abnormal_cardiomyocyte_apopto1.08794395
51MP0002722_abnormal_immune_system1.06857487
52MP0003943_abnormal_hepatobiliary_system1.06808697
53MP0006054_spinal_hemorrhage1.04306564
54MP0003566_abnormal_cell_adhesion1.02609231
55MP0003705_abnormal_hypodermis_morpholog1.02300424
56MP0003718_maternal_effect1.02167700
57MP0000689_abnormal_spleen_morphology1.01893613
58MP0004264_abnormal_extraembryonic_tissu1.01232105
59MP0001145_abnormal_male_reproductive0.98704991
60MP0009333_abnormal_splenocyte_physiolog0.97346497
61MP0001915_intracranial_hemorrhage0.96530924
62MP0010234_abnormal_vibrissa_follicle0.95956852
63MP0000358_abnormal_cell_content/0.95837382
64MP0003937_abnormal_limbs/digits/tail_de0.95174359
65MP0009703_decreased_birth_body0.94106221
66MP0000569_abnormal_digit_pigmentation0.93778121
67MP0000537_abnormal_urethra_morphology0.92426840
68MP0009053_abnormal_anal_canal0.91907832
69MP0009672_abnormal_birth_weight0.91719613
70MP0006292_abnormal_olfactory_placode0.90685758
71MP0003941_abnormal_skin_development0.90097905
72MP0001929_abnormal_gametogenesis0.88166607
73MP0001661_extended_life_span0.86957895
74MP0005621_abnormal_cell_physiology0.86904394
75MP0002429_abnormal_blood_cell0.85843303
76MP0004233_abnormal_muscle_weight0.85106819
77MP0000653_abnormal_sex_gland0.84317316
78MP0005384_cellular_phenotype0.83465179
79MP0009278_abnormal_bone_marrow0.82374985
80MP0002751_abnormal_autonomic_nervous0.82305415
81MP0002111_abnormal_tail_morphology0.81737636
82MP0005023_abnormal_wound_healing0.81534911
83MP0000858_altered_metastatic_potential0.79960836
84MP0003861_abnormal_nervous_system0.79580077
85MP0002092_abnormal_eye_morphology0.78700471
86MP0001119_abnormal_female_reproductive0.78236449
87MP0003698_abnormal_male_reproductive0.77899426
88MP0002233_abnormal_nose_morphology0.77583831
89MP0002925_abnormal_cardiovascular_devel0.77436835
90MP0002006_tumorigenesis0.76793089
91MP0000716_abnormal_immune_system0.76377264
92MP0010030_abnormal_orbit_morphology0.76320709
93MP0001800_abnormal_humoral_immune0.76192056
94MP0003119_abnormal_digestive_system0.75856788
95MP0003699_abnormal_female_reproductive0.74768888
96MP0002877_abnormal_melanocyte_morpholog0.74724120
97MP0001286_abnormal_eye_development0.74705790
98MP0003115_abnormal_respiratory_system0.74595573
99MP0008789_abnormal_olfactory_epithelium0.74517867
100MP0004185_abnormal_adipocyte_glucose0.74219138
101MP0000372_irregular_coat_pigmentation0.73891482
102MP0006072_abnormal_retinal_apoptosis0.73715657
103MP0000733_abnormal_muscle_development0.73343131
104MP0000432_abnormal_head_morphology0.71970772
105MP0005391_vision/eye_phenotype0.70778434
106MP0002075_abnormal_coat/hair_pigmentati0.70039724
107MP0000647_abnormal_sebaceous_gland0.69120623
108MP0003787_abnormal_imprinting0.68766848
109MP0002166_altered_tumor_susceptibility0.68385525
110MP0000371_diluted_coat_color0.68019417
111MP0001346_abnormal_lacrimal_gland0.67625723
112MP0000428_abnormal_craniofacial_morphol0.67591433
113MP0002697_abnormal_eye_size0.66967132
114MP0001849_ear_inflammation0.66381793
115MP0001529_abnormal_vocalization0.66322192
116MP0005499_abnormal_olfactory_system0.65076301
117MP0005394_taste/olfaction_phenotype0.65076301
118MP0002161_abnormal_fertility/fecundity0.64874771
119MP0003448_altered_tumor_morphology0.64459811
120MP0005395_other_phenotype0.63631697
121MP0003315_abnormal_perineum_morphology0.63539155
122MP0000477_abnormal_intestine_morphology0.63516507
123MP0010678_abnormal_skin_adnexa0.63480452
124MP0003935_abnormal_craniofacial_develop0.62426403
125MP0004133_heterotaxia0.62070790
126MP0005671_abnormal_response_to0.61708365
127MP0005647_abnormal_sex_gland0.59726918
128MP0002420_abnormal_adaptive_immunity0.59161122
129MP0002452_abnormal_antigen_presenting0.59036017
130MP0003806_abnormal_nucleotide_metabolis0.58739167
131MP0001819_abnormal_immune_cell0.57635289
132MP0002095_abnormal_skin_pigmentation0.56687530
133MP0002405_respiratory_system_inflammati0.55637050

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.57804209
2Birth length less than 3rd percentile (HP:0003561)4.34420931
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26200768
4Abnormality of chromosome stability (HP:0003220)3.68189490
5Ependymoma (HP:0002888)3.68113615
6Medulloblastoma (HP:0002885)3.52500585
7Selective tooth agenesis (HP:0001592)3.24426785
8Volvulus (HP:0002580)3.22138633
9Meckel diverticulum (HP:0002245)3.05570770
10Ectopic kidney (HP:0000086)3.04220308
11Abnormality of the labia minora (HP:0012880)3.03426630
12Agnosia (HP:0010524)3.02519546
13Cortical dysplasia (HP:0002539)3.01499370
14Abnormality of the preputium (HP:0100587)2.97977274
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.97064840
16Colon cancer (HP:0003003)2.94051681
17Abnormality of the ileum (HP:0001549)2.92413297
18Patellar aplasia (HP:0006443)2.91842264
19Reticulocytopenia (HP:0001896)2.88599116
20Myelodysplasia (HP:0002863)2.84997983
21Impulsivity (HP:0100710)2.74415484
22Breast hypoplasia (HP:0003187)2.72070541
23Rhabdomyosarcoma (HP:0002859)2.71856332
2411 pairs of ribs (HP:0000878)2.66495323
25Aplasia/Hypoplasia of the patella (HP:0006498)2.66031819
26Small intestinal stenosis (HP:0012848)2.64189126
27Duodenal stenosis (HP:0100867)2.64189126
28Abnormality of the astrocytes (HP:0100707)2.64013670
29Astrocytoma (HP:0009592)2.64013670
30Multiple enchondromatosis (HP:0005701)2.62883535
31Microvesicular hepatic steatosis (HP:0001414)2.62166359
32Deviation of the thumb (HP:0009603)2.60450449
33Proximal placement of thumb (HP:0009623)2.57133800
34Increased nuchal translucency (HP:0010880)2.54915434
35Neoplasm of the oral cavity (HP:0100649)2.54508798
36Short 4th metacarpal (HP:0010044)2.50024253
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50024253
38Absent thumb (HP:0009777)2.48284340
39Prominent nose (HP:0000448)2.46094470
40Glioma (HP:0009733)2.44760812
41Basal cell carcinoma (HP:0002671)2.44398635
42Absent radius (HP:0003974)2.42604063
43Amaurosis fugax (HP:0100576)2.42181940
44Sloping forehead (HP:0000340)2.36239630
45Abnormality of homocysteine metabolism (HP:0010919)2.36195114
46Homocystinuria (HP:0002156)2.36195114
47Abnormality of the fingertips (HP:0001211)2.35427875
48Duplicated collecting system (HP:0000081)2.29133950
49Long eyelashes (HP:0000527)2.28222106
50Degeneration of anterior horn cells (HP:0002398)2.27934320
51Abnormality of the anterior horn cell (HP:0006802)2.27934320
52Abnormality of the carotid arteries (HP:0005344)2.26916330
53Bone marrow hypocellularity (HP:0005528)2.26476043
54Absent forearm bone (HP:0003953)2.25044258
55Aplasia involving forearm bones (HP:0009822)2.25044258
56Cafe-au-lait spot (HP:0000957)2.24908220
57Neoplasm of striated muscle (HP:0009728)2.20588620
58Spastic diplegia (HP:0001264)2.19548274
59Missing ribs (HP:0000921)2.19202223
60Choanal atresia (HP:0000453)2.18706665
61Abnormality of the duodenum (HP:0002246)2.16643995
62Abnormal number of incisors (HP:0011064)2.15900543
63Oral leukoplakia (HP:0002745)2.15529124
64Supernumerary spleens (HP:0009799)2.12992896
65Abnormality of DNA repair (HP:0003254)2.12438127
66High pitched voice (HP:0001620)2.12099312
67Hypoplastic pelvis (HP:0008839)2.11533304
68Premature graying of hair (HP:0002216)2.09667186
69Clubbing of toes (HP:0100760)2.08619037
70High anterior hairline (HP:0009890)2.07431778
71Carpal bone hypoplasia (HP:0001498)2.06167702
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.06019870
73Atresia of the external auditory canal (HP:0000413)2.05671120
74Lymphoma (HP:0002665)2.05452219
75Abnormality of methionine metabolism (HP:0010901)2.04758924
76Abnormal lung lobation (HP:0002101)2.03472075
77Abnormality of the renal collecting system (HP:0004742)2.01665958
78Pancreatic islet-cell hyperplasia (HP:0004510)2.01338555
79Squamous cell carcinoma (HP:0002860)2.01100048
80Embryonal neoplasm (HP:0002898)2.00251205
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99160284
82Breast carcinoma (HP:0003002)1.98721399
83Gonadotropin excess (HP:0000837)1.96258158
84Facial hemangioma (HP:0000329)1.95882301
85B lymphocytopenia (HP:0010976)1.95867891
86Tracheoesophageal fistula (HP:0002575)1.95557670
87Neoplasm of the pancreas (HP:0002894)1.94603947
88Arteriovenous malformation (HP:0100026)1.93606511
89Biliary tract neoplasm (HP:0100574)1.91162703
90Abnormality of chromosome segregation (HP:0002916)1.89952919
91Rough bone trabeculation (HP:0100670)1.89150846
92Deep philtrum (HP:0002002)1.87923905
93Acute myeloid leukemia (HP:0004808)1.87225639
94Abnormality of glycolysis (HP:0004366)1.84390385
95Short thumb (HP:0009778)1.84164994
96Oligodactyly (hands) (HP:0001180)1.83692295
97IgM deficiency (HP:0002850)1.83477554
98Cellular immunodeficiency (HP:0005374)1.83107559
99Nephroblastoma (Wilms tumor) (HP:0002667)1.82289354
100Ovarian neoplasm (HP:0100615)1.81157844
101Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79422748
102Skull defect (HP:0001362)1.78763990
103Sandal gap (HP:0001852)1.77474295
104Gastrointestinal carcinoma (HP:0002672)1.75267328
105Malignant gastrointestinal tract tumors (HP:0006749)1.75267328
106Intestinal atresia (HP:0011100)1.74972794
107Facial cleft (HP:0002006)1.74934830
108Aplastic anemia (HP:0001915)1.73414485
109Broad palm (HP:0001169)1.72338880
110Horseshoe kidney (HP:0000085)1.70641844
111Abnormality of alanine metabolism (HP:0010916)1.70611253
112Hyperalaninemia (HP:0003348)1.70611253
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70611253
114Abnormality of abdominal situs (HP:0011620)1.69621051
115Abdominal situs inversus (HP:0003363)1.69621051
116Abnormality of serum amino acid levels (HP:0003112)1.68900350
117Sparse lateral eyebrow (HP:0005338)1.68798881
118Increased serum pyruvate (HP:0003542)1.68371823
119Embryonal renal neoplasm (HP:0011794)1.68330151
120Cutaneous melanoma (HP:0012056)1.68274484
121Overlapping toe (HP:0001845)1.66340942
122Aplasia/hypoplasia of the humerus (HP:0006507)1.66097019
123Heterotopia (HP:0002282)1.65552962
124Cutis marmorata (HP:0000965)1.65419860
125Neoplasm of the colon (HP:0100273)1.64252002
126Triphalangeal thumb (HP:0001199)1.64203606
127Rib fusion (HP:0000902)1.63406675
128T lymphocytopenia (HP:0005403)1.63358735
129Leukopenia (HP:0001882)1.62943659
130Esophageal atresia (HP:0002032)1.61950013
131Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61824599
132Partial agenesis of the corpus callosum (HP:0001338)1.59182306
133Neoplasm of the small intestine (HP:0100833)1.59033055
134Abnormality of cochlea (HP:0000375)1.58815419
135Obsessive-compulsive behavior (HP:0000722)1.56339383
136Megaloblastic anemia (HP:0001889)1.56251880
137Acute lymphatic leukemia (HP:0006721)1.55669504
138Oligodactyly (HP:0012165)1.54344946
139Central scotoma (HP:0000603)1.53632235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.72341916
2WEE13.89722205
3CDK123.58777999
4BUB12.98000464
5NEK22.76967325
6TTK2.74245696
7SRPK12.32032366
8TSSK62.29295140
9PBK2.28505041
10EIF2AK12.25045085
11EEF2K2.21301700
12PLK42.20509525
13ATR2.14489850
14BRSK22.13209720
15STK101.97941284
16NEK11.94861583
17PLK11.92425132
18CDK71.86751939
19RPS6KB21.85548752
20MKNK11.85393312
21TAF11.82657825
22EPHA21.76829141
23PLK31.76684716
24PASK1.76131092
25ACVR1B1.74653340
26BRD41.74014559
27AURKB1.70362950
28CHEK21.69420935
29TRIM281.67991604
30VRK21.67190601
31PDK21.65029007
32CHEK11.57714061
33MAP3K81.51351661
34CDK41.46809203
35STK41.42035864
36RPS6KA41.39954614
37MAP3K101.38822843
38ZAK1.37183399
39MKNK21.37110880
40VRK11.31391385
41MAP4K11.30138975
42ATM1.29103302
43STK31.22607811
44DYRK31.21225332
45EIF2AK31.20408271
46SMG11.19937823
47TGFBR11.19013397
48NUAK11.16789276
49BRSK11.08366960
50TLK11.07779006
51PIM11.07473671
52CSNK1G11.05938358
53MST41.05909357
54CDK21.03961467
55PKN21.02847080
56SCYL21.02479107
57LATS11.01068657
58CDK60.99998249
59ALK0.95371108
60BCR0.93185544
61FLT30.92742237
62PAK40.87118836
63MELK0.86226555
64CLK10.83140781
65AURKA0.82903880
66WNK30.80830709
67CDK10.80798928
68MTOR0.75732974
69CSNK1G30.72970880
70TESK20.72175473
71CCNB10.70927217
72ERBB40.69283532
73CSNK1A1L0.64816144
74CDK80.64785154
75STK38L0.61903313
76JAK30.61582382
77CSNK1D0.59420548
78CSNK2A20.59329101
79ERBB30.58419410
80FGFR10.58152961
81RPS6KA50.56034358
82FGFR20.54997604
83PRKDC0.54458201
84MAP2K30.53521137
85NME20.50705053
86MARK30.50686385
87MST1R0.49343076
88NEK90.49112630
89CSNK2A10.47857026
90PNCK0.47047196
91BTK0.46935253
92EIF2AK20.46858980
93NEK60.46447420
94CSNK1G20.45827420
95MAPK140.45664642
96LRRK20.44555270
97CHUK0.44143029
98MAP3K40.44091089
99NLK0.44006006
100CDK90.41183827
101NME10.40954235
102CDK30.39280437
103BMPR1B0.38631431
104PAK10.38309002
105TXK0.37290709
106CSNK1E0.36787381
107STK390.36643150
108RPS6KB10.36516243
109DAPK10.36339446
110ZAP700.35640066
111AKT10.34710290
112MAPK10.34629120
113CSF1R0.33660888
114MAP3K90.33527595
115RAF10.33418614
116MAPKAPK50.33137237
117TAOK20.32771792
118PAK20.32761228
119PRKCI0.31197272
120STK240.30729799
121BRAF0.30727852
122GSK3B0.29853510
123YES10.29486742
124CAMK1D0.28294610
125AKT20.27911919
126MAPK110.26517473
127CAMK1G0.25982327
128MAP3K50.25970698
129TEC0.25571808
130KSR10.25178436
131AKT30.24541010
132FGFR30.22907024
133TTN0.22683869

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62824551
2Mismatch repair_Homo sapiens_hsa034304.19014632
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57594471
4* RNA transport_Homo sapiens_hsa030133.14429444
5Cell cycle_Homo sapiens_hsa041103.07683705
6Spliceosome_Homo sapiens_hsa030402.97867134
7Homologous recombination_Homo sapiens_hsa034402.95156973
8One carbon pool by folate_Homo sapiens_hsa006702.93448471
9Base excision repair_Homo sapiens_hsa034102.88362066
10Non-homologous end-joining_Homo sapiens_hsa034502.73016699
11Nucleotide excision repair_Homo sapiens_hsa034202.69869372
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67572850
13Fanconi anemia pathway_Homo sapiens_hsa034602.55424127
14RNA polymerase_Homo sapiens_hsa030202.37165656
15RNA degradation_Homo sapiens_hsa030182.04707511
16mRNA surveillance pathway_Homo sapiens_hsa030152.03332379
17p53 signaling pathway_Homo sapiens_hsa041151.86113367
18Pyrimidine metabolism_Homo sapiens_hsa002401.84194069
19Basal transcription factors_Homo sapiens_hsa030221.75694308
20Ribosome_Homo sapiens_hsa030101.64420112
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58710574
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56932997
23Systemic lupus erythematosus_Homo sapiens_hsa053221.53867742
24Proteasome_Homo sapiens_hsa030501.51934445
25Viral carcinogenesis_Homo sapiens_hsa052031.35735409
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27042562
27Epstein-Barr virus infection_Homo sapiens_hsa051691.26119780
28Steroid biosynthesis_Homo sapiens_hsa001001.21594201
29Herpes simplex infection_Homo sapiens_hsa051681.21167524
30Antigen processing and presentation_Homo sapiens_hsa046121.18664768
31MicroRNAs in cancer_Homo sapiens_hsa052061.14239384
32Carbon metabolism_Homo sapiens_hsa012001.08578855
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07086722
34Protein export_Homo sapiens_hsa030601.05747044
35HTLV-I infection_Homo sapiens_hsa051661.03454472
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03154948
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00898392
38Primary immunodeficiency_Homo sapiens_hsa053401.00698071
39Small cell lung cancer_Homo sapiens_hsa052220.97167554
40Pyruvate metabolism_Homo sapiens_hsa006200.96990812
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96804544
42Oocyte meiosis_Homo sapiens_hsa041140.95830000
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95729863
44Purine metabolism_Homo sapiens_hsa002300.93832271
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93729418
46Propanoate metabolism_Homo sapiens_hsa006400.91104827
47Selenocompound metabolism_Homo sapiens_hsa004500.89664432
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.85505189
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81477897
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80414734
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76258115
52Measles_Homo sapiens_hsa051620.73033536
53Thyroid cancer_Homo sapiens_hsa052160.71258127
54Legionellosis_Homo sapiens_hsa051340.71033164
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70307555
56Colorectal cancer_Homo sapiens_hsa052100.68763335
57Chronic myeloid leukemia_Homo sapiens_hsa052200.68643089
58Hepatitis B_Homo sapiens_hsa051610.67007559
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65874751
60Lysine degradation_Homo sapiens_hsa003100.65772527
61Apoptosis_Homo sapiens_hsa042100.65695676
62Hematopoietic cell lineage_Homo sapiens_hsa046400.63751576
63TGF-beta signaling pathway_Homo sapiens_hsa043500.63195118
64Adherens junction_Homo sapiens_hsa045200.61422285
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59554973
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59385382
67Notch signaling pathway_Homo sapiens_hsa043300.58739054
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57190438
69Alcoholism_Homo sapiens_hsa050340.56528764
70Hippo signaling pathway_Homo sapiens_hsa043900.56276725
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56210751
72Viral myocarditis_Homo sapiens_hsa054160.55350056
73Basal cell carcinoma_Homo sapiens_hsa052170.52891185
74mTOR signaling pathway_Homo sapiens_hsa041500.51378215
75Influenza A_Homo sapiens_hsa051640.50015705
76Prostate cancer_Homo sapiens_hsa052150.49853677
77Biosynthesis of amino acids_Homo sapiens_hsa012300.49848754
78Pentose phosphate pathway_Homo sapiens_hsa000300.46066323
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45812257
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.45646441
81Fatty acid elongation_Homo sapiens_hsa000620.45635430
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.45279372
83Pathways in cancer_Homo sapiens_hsa052000.44460830
84B cell receptor signaling pathway_Homo sapiens_hsa046620.43607986
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43419854
86Pancreatic cancer_Homo sapiens_hsa052120.41541206
87Shigellosis_Homo sapiens_hsa051310.41423451
88Acute myeloid leukemia_Homo sapiens_hsa052210.40923546
89HIF-1 signaling pathway_Homo sapiens_hsa040660.40714212
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.40555493
91Non-small cell lung cancer_Homo sapiens_hsa052230.39638578
92Folate biosynthesis_Homo sapiens_hsa007900.38383333
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38348870
94Fatty acid metabolism_Homo sapiens_hsa012120.38079738
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37439327
96T cell receptor signaling pathway_Homo sapiens_hsa046600.37435057
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.37341946
98Vitamin B6 metabolism_Homo sapiens_hsa007500.37311811
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36734183
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36287484
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.35845268
102FoxO signaling pathway_Homo sapiens_hsa040680.34774997
103Bladder cancer_Homo sapiens_hsa052190.33782832
104Toxoplasmosis_Homo sapiens_hsa051450.32654851
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.32455308
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32188805
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32073025
108Proteoglycans in cancer_Homo sapiens_hsa052050.31275924
109Leishmaniasis_Homo sapiens_hsa051400.30684055
110Endometrial cancer_Homo sapiens_hsa052130.30539870
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28003445
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.27664438
113Arginine biosynthesis_Homo sapiens_hsa002200.26767661
114Metabolic pathways_Homo sapiens_hsa011000.26450701
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25701060
116Wnt signaling pathway_Homo sapiens_hsa043100.24425095
117TNF signaling pathway_Homo sapiens_hsa046680.24067939
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23704146
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23062547
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21829362
121Melanoma_Homo sapiens_hsa052180.21820346
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21789119
123N-Glycan biosynthesis_Homo sapiens_hsa005100.21645421
124Caffeine metabolism_Homo sapiens_hsa002320.18970931
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18806782
126Tight junction_Homo sapiens_hsa045300.18611261
127Allograft rejection_Homo sapiens_hsa053300.18590966
128Hedgehog signaling pathway_Homo sapiens_hsa043400.16706020
129Glutathione metabolism_Homo sapiens_hsa004800.14117366
130Fatty acid biosynthesis_Homo sapiens_hsa000610.14053068
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11470883
132Vitamin digestion and absorption_Homo sapiens_hsa049770.11134572
133Butanoate metabolism_Homo sapiens_hsa006500.08403490

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