NUP153

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* nuclear pore complex assembly (GO:0051292)5.74800264
2* nuclear pore organization (GO:0006999)5.50542396
3mitotic sister chromatid cohesion (GO:0007064)5.00025012
4DNA unwinding involved in DNA replication (GO:0006268)4.21754357
5* pore complex assembly (GO:0046931)4.19428980
6protein localization to kinetochore (GO:0034501)4.14791162
7pre-miRNA processing (GO:0031054)4.09270991
8* mitotic nuclear envelope disassembly (GO:0007077)4.04695558
9regulation of histone H3-K9 methylation (GO:0051570)3.95483370
10mitotic chromosome condensation (GO:0007076)3.89934524
11negative regulation of histone methylation (GO:0031061)3.85158838
12heterochromatin organization (GO:0070828)3.83655874
13* membrane disassembly (GO:0030397)3.82305509
14* nuclear envelope disassembly (GO:0051081)3.82305509
15protein localization to chromosome, centromeric region (GO:0071459)3.80396486
16DNA replication-dependent nucleosome assembly (GO:0006335)3.66912114
17DNA replication-dependent nucleosome organization (GO:0034723)3.66912114
18regulation of histone H3-K27 methylation (GO:0061085)3.65058285
19dosage compensation (GO:0007549)3.63266706
20DNA duplex unwinding (GO:0032508)3.58039823
21protein export from nucleus (GO:0006611)3.56861902
22DNA geometric change (GO:0032392)3.56748089
23DNA synthesis involved in DNA repair (GO:0000731)3.51922543
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.48152763
25sister chromatid segregation (GO:0000819)3.46067969
26monoubiquitinated protein deubiquitination (GO:0035520)3.45197333
27chromatin assembly (GO:0031497)3.42544038
28positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40142565
29positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40142565
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.40142565
31spliceosomal tri-snRNP complex assembly (GO:0000244)3.38596397
32cellular protein complex localization (GO:0034629)3.36991182
33telomere maintenance via semi-conservative replication (GO:0032201)3.34833352
34* regulation of nucleobase-containing compound transport (GO:0032239)3.33901044
35regulation of sister chromatid cohesion (GO:0007063)3.29348273
36positive regulation of chromosome segregation (GO:0051984)3.27235660
37mRNA stabilization (GO:0048255)3.22974499
38RNA stabilization (GO:0043489)3.22974499
39regulation of centriole replication (GO:0046599)3.21755179
40* regulation of RNA export from nucleus (GO:0046831)3.21472431
41mitotic sister chromatid segregation (GO:0000070)3.21331215
42protein complex localization (GO:0031503)3.20918853
43DNA replication initiation (GO:0006270)3.20878001
44regulation of spindle organization (GO:0090224)3.20696946
45histone H2A monoubiquitination (GO:0035518)3.17022141
46gene silencing by RNA (GO:0031047)3.16178409
47histone H3-K36 demethylation (GO:0070544)3.15481460
48formation of translation preinitiation complex (GO:0001731)3.14524032
49kinetochore organization (GO:0051383)3.14038187
50folic acid-containing compound biosynthetic process (GO:0009396)3.13981193
51mitotic metaphase plate congression (GO:0007080)3.13094691
52ribosome assembly (GO:0042255)3.08505431
53DNA conformation change (GO:0071103)3.07650828
54chromatin assembly or disassembly (GO:0006333)3.05122107
55chromosome condensation (GO:0030261)3.04777984
56translesion synthesis (GO:0019985)3.03936685
57regulation of histone methylation (GO:0031060)3.03907859
58NLS-bearing protein import into nucleus (GO:0006607)3.02183211
59regulation of mitotic spindle organization (GO:0060236)3.02108323
60meiotic chromosome segregation (GO:0045132)3.01994670
61negative regulation of DNA repair (GO:0045738)3.01697652
62IMP biosynthetic process (GO:0006188)3.01550791
63telomere maintenance via recombination (GO:0000722)3.00593545
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00358292
65regulation of histone H3-K4 methylation (GO:0051569)3.00348375
66regulation of DNA endoreduplication (GO:0032875)2.97310779
67protein localization to chromosome (GO:0034502)2.97101652
68* nuclear envelope organization (GO:0006998)2.96390647
69metaphase plate congression (GO:0051310)2.95679718
70mitotic recombination (GO:0006312)2.95292951
71sister chromatid cohesion (GO:0007062)2.92773433
72embryonic process involved in female pregnancy (GO:0060136)2.91923255
73glucocorticoid receptor signaling pathway (GO:0042921)2.91559991
74regulation of translational termination (GO:0006449)2.90390468
75DNA packaging (GO:0006323)2.89392421
76attachment of spindle microtubules to kinetochore (GO:0008608)2.86786386
77chromosome segregation (GO:0007059)2.85733301
78regulation of DNA damage checkpoint (GO:2000001)2.84406880
79double-strand break repair via nonhomologous end joining (GO:0006303)2.83265560
80non-recombinational repair (GO:0000726)2.83265560
81regulation of centrosome cycle (GO:0046605)2.80373346
82regulation of NFAT protein import into nucleus (GO:0051532)2.80262771
83gene silencing (GO:0016458)2.79951881
84regulation of gene silencing by RNA (GO:0060966)2.79607969
85regulation of posttranscriptional gene silencing (GO:0060147)2.79607969
86regulation of gene silencing by miRNA (GO:0060964)2.79607969
87regulation of chromatin binding (GO:0035561)2.78233143
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77931982
89DNA strand elongation involved in DNA replication (GO:0006271)2.77506541
90negative regulation of histone modification (GO:0031057)2.76811545
91* mRNA transport (GO:0051028)2.76289995
92regulation of mRNA stability (GO:0043488)2.74252263
93histone mRNA catabolic process (GO:0071044)2.73449658
94regulation of translational fidelity (GO:0006450)2.73198790
95DNA replication-independent nucleosome organization (GO:0034724)2.73160523
96DNA replication-independent nucleosome assembly (GO:0006336)2.73160523
97IMP metabolic process (GO:0046040)2.72657417
98regulation of chromosome segregation (GO:0051983)2.72110720
99negative regulation of mRNA processing (GO:0050686)2.71982593
100alternative mRNA splicing, via spliceosome (GO:0000380)2.68194201
101peptidyl-lysine dimethylation (GO:0018027)2.68166697
102DNA topological change (GO:0006265)2.68129145
103histone phosphorylation (GO:0016572)2.67895218
104V(D)J recombination (GO:0033151)2.65576079
105histone H2B ubiquitination (GO:0033523)2.65482459
106negative regulation of RNA splicing (GO:0033119)2.65334549
107DNA replication checkpoint (GO:0000076)2.65108654
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.64664258
109negative regulation of chromosome segregation (GO:0051985)2.64003306
110establishment of chromosome localization (GO:0051303)2.63950277
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63916657
112negative regulation of chromatin modification (GO:1903309)2.63290970
113histone lysine demethylation (GO:0070076)2.62762069
114ATP-dependent chromatin remodeling (GO:0043044)2.62743059
115positive regulation of cell cycle checkpoint (GO:1901978)2.62695807
116DNA strand elongation (GO:0022616)2.61924209
117cytoplasmic mRNA processing body assembly (GO:0033962)2.61698423
118regulation of helicase activity (GO:0051095)2.61185855
119positive regulation of DNA-dependent DNA replication (GO:2000105)2.60725013
120regulation of RNA stability (GO:0043487)2.60595613
121protein K6-linked ubiquitination (GO:0085020)2.60140439
122chromatin remodeling at centromere (GO:0031055)2.59580537
1233-UTR-mediated mRNA stabilization (GO:0070935)2.59540086
124nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58428774
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56212551
126histone exchange (GO:0043486)2.55759431
127* RNA transport (GO:0050658)2.54312199
128* establishment of RNA localization (GO:0051236)2.54312199
129* nucleic acid transport (GO:0050657)2.54312199
130regulation of centrosome duplication (GO:0010824)2.53425183
131negative regulation of mRNA metabolic process (GO:1903312)2.53343633
132microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.52648322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.39735428
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.07472191
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97178778
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00354199
5MYC_22102868_ChIP-Seq_BL_Human2.92536099
6* MYC_18555785_ChIP-Seq_MESCs_Mouse2.86205209
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69263777
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.66692868
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57601933
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48263133
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35904252
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.30477617
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29708869
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.28100450
15AR_21909140_ChIP-Seq_LNCAP_Human2.22801875
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18649414
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18421203
18E2F7_22180533_ChIP-Seq_HELA_Human10.3243235
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91992657
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84583012
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82522683
22* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.71484499
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71380993
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.66260045
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63719605
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63696609
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60492517
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57287965
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.53595551
30CIITA_25753668_ChIP-Seq_RAJI_Human1.49055449
31VDR_21846776_ChIP-Seq_THP-1_Human1.48883296
32GATA1_22025678_ChIP-Seq_K562_Human1.47885673
33* XRN2_22483619_ChIP-Seq_HELA_Human1.46049994
34MYB_26560356_Chip-Seq_TH1_Human1.44543517
35MYB_26560356_Chip-Seq_TH2_Human1.40800974
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38115466
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37850190
38* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37721442
39KDM5A_27292631_Chip-Seq_BREAST_Human1.37162831
40* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36782116
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34624001
42MAF_26560356_Chip-Seq_TH1_Human1.33186435
43* UTX_26944678_Chip-Seq_JUKART_Human1.32421968
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32221873
45VDR_23849224_ChIP-Seq_CD4+_Human1.31596644
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31113402
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28526990
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27859159
49ZNF263_19887448_ChIP-Seq_K562_Human1.26152005
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24813401
51* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23680125
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23350300
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22314090
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21401900
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20729406
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18283214
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17784194
58FOXP3_21729870_ChIP-Seq_TREG_Human1.17614873
59ELK1_19687146_ChIP-ChIP_HELA_Human1.17563444
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17548833
61* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17178831
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.15230642
63* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14455309
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13842651
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13773628
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12515774
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10642641
68CLOCK_20551151_ChIP-Seq_293T_Human1.09660355
69TFEB_21752829_ChIP-Seq_HELA_Human1.09294602
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08570469
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08452774
72KDM2B_26808549_Chip-Seq_DND41_Human1.08225885
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07245905
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06856666
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06814180
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06196786
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05737282
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05732272
79* TTF2_22483619_ChIP-Seq_HELA_Human1.05480530
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03837005
81* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01149528
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00489306
83* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98901593
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97146210
85NCOR1_26117541_ChIP-Seq_K562_Human0.97028353
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96879484
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96630614
88* EST1_17652178_ChIP-ChIP_JURKAT_Human0.96574463
89RUNX1_22412390_ChIP-Seq_EML_Mouse0.96536478
90* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96499528
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95272321
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94975040
93CHD1_26751641_Chip-Seq_LNCaP_Human0.94182999
94CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94123991
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93943936
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93934732
97* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93614031
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93598309
99* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93451954
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93239707
101* NANOG_21062744_ChIP-ChIP_HESCs_Human0.93109195
102* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93106885
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92862920
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92862920
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92862920
106* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92244220
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91694955
108* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90523622
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89180887
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88383389
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87755704
112* SPI1_23547873_ChIP-Seq_NB4_Human0.87438092
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87120708
114SCL_19346495_ChIP-Seq_HPC-7_Human0.86619059
115* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84951311
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84757334
117MAF_26560356_Chip-Seq_TH2_Human0.84545802
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.84284904
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84248833
120DCP1A_22483619_ChIP-Seq_HELA_Human0.84027749
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83477526
122* GABP_19822575_ChIP-Seq_HepG2_Human0.81808564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.53326307
2MP0008057_abnormal_DNA_replication3.52496670
3MP0003111_abnormal_nucleus_morphology3.17305388
4MP0010352_gastrointestinal_tract_polyps3.15199893
5MP0003077_abnormal_cell_cycle3.03119777
6MP0003693_abnormal_embryo_hatching3.02542648
7MP0004957_abnormal_blastocyst_morpholog2.91115844
8MP0010307_abnormal_tumor_latency2.62726817
9MP0008877_abnormal_DNA_methylation2.51179450
10MP0005076_abnormal_cell_differentiation2.50089216
11MP0005451_abnormal_body_composition2.30119239
12MP0002396_abnormal_hematopoietic_system2.29795239
13MP0004808_abnormal_hematopoietic_stem2.18227645
14MP0001730_embryonic_growth_arrest2.14684198
15MP0003705_abnormal_hypodermis_morpholog2.13481183
16MP0008007_abnormal_cellular_replicative2.13067082
17MP0000350_abnormal_cell_proliferation2.10821232
18MP0008058_abnormal_DNA_repair2.10017627
19MP0003763_abnormal_thymus_physiology1.91079544
20MP0003123_paternal_imprinting1.87669634
21MP0004197_abnormal_fetal_growth/weight/1.82237065
22MP0001672_abnormal_embryogenesis/_devel1.78386298
23MP0005380_embryogenesis_phenotype1.78386298
24MP0003984_embryonic_growth_retardation1.69071291
25MP0002084_abnormal_developmental_patter1.68943958
26MP0002086_abnormal_extraembryonic_tissu1.68115490
27MP0002088_abnormal_embryonic_growth/wei1.67657312
28MP0009697_abnormal_copulation1.65726194
29MP0001697_abnormal_embryo_size1.65721321
30MP0004233_abnormal_muscle_weight1.65438941
31MP0003300_gastrointestinal_ulcer1.60448447
32MP0003121_genomic_imprinting1.58047283
33MP0008932_abnormal_embryonic_tissue1.53437705
34MP0000703_abnormal_thymus_morphology1.51009028
35MP0002085_abnormal_embryonic_tissue1.50943582
36MP0009278_abnormal_bone_marrow1.49424956
37MP0003890_abnormal_embryonic-extraembry1.47027011
38MP0003656_abnormal_erythrocyte_physiolo1.45439113
39MP0001545_abnormal_hematopoietic_system1.42583412
40MP0005397_hematopoietic_system_phenotyp1.42583412
41MP0002398_abnormal_bone_marrow1.41441600
42MP0000490_abnormal_crypts_of1.39020594
43MP0010234_abnormal_vibrissa_follicle1.38947084
44MP0002080_prenatal_lethality1.38693433
45MP0003566_abnormal_cell_adhesion1.31649067
46MP0002166_altered_tumor_susceptibility1.30878588
47MP0003221_abnormal_cardiomyocyte_apopto1.30687712
48MP0000569_abnormal_digit_pigmentation1.29686215
49MP0003567_abnormal_fetal_cardiomyocyte1.29108628
50MP0002019_abnormal_tumor_incidence1.25627537
51MP0000733_abnormal_muscle_development1.23787908
52MP0005023_abnormal_wound_healing1.23414472
53MP0003786_premature_aging1.22955321
54MP0003303_peritoneal_inflammation1.22015527
55MP0001929_abnormal_gametogenesis1.19172473
56MP0002722_abnormal_immune_system1.18957248
57MP0001293_anophthalmia1.18928906
58MP0002210_abnormal_sex_determination1.18627969
59MP0002006_tumorigenesis1.15098758
60MP0000313_abnormal_cell_death1.14843126
61MP0000689_abnormal_spleen_morphology1.13090424
62MP0002877_abnormal_melanocyte_morpholog1.12478459
63MP0001800_abnormal_humoral_immune1.11483627
64MP0009053_abnormal_anal_canal1.11171172
65MP0001915_intracranial_hemorrhage1.09966113
66MP0003453_abnormal_keratinocyte_physiol1.09190253
67MP0000685_abnormal_immune_system1.08955022
68MP0001661_extended_life_span1.06356262
69MP0005409_darkened_coat_color1.05779841
70MP0001145_abnormal_male_reproductive1.04465729
71MP0002796_impaired_skin_barrier1.02407658
72MP0009703_decreased_birth_body1.00679422
73MP0000537_abnormal_urethra_morphology1.00602030
74MP0003787_abnormal_imprinting0.98553613
75MP0009333_abnormal_splenocyte_physiolog0.97463883
76MP0005384_cellular_phenotype0.96895011
77MP0002405_respiratory_system_inflammati0.95856652
78MP0000716_abnormal_immune_system0.95681946
79MP0003941_abnormal_skin_development0.95666345
80MP0002925_abnormal_cardiovascular_devel0.94261068
81MP0009672_abnormal_birth_weight0.94005660
82MP0002429_abnormal_blood_cell0.93938202
83MP0003943_abnormal_hepatobiliary_system0.92250410
84MP0001348_abnormal_lacrimal_gland0.91790435
85MP0002092_abnormal_eye_morphology0.91389868
86MP0001346_abnormal_lacrimal_gland0.91313667
87MP0005410_abnormal_fertilization0.90342109
88MP0003091_abnormal_cell_migration0.89820825
89MP0004185_abnormal_adipocyte_glucose0.89104242
90MP0000653_abnormal_sex_gland0.88569044
91MP0006054_spinal_hemorrhage0.87778731
92MP0002420_abnormal_adaptive_immunity0.87506825
93MP0005501_abnormal_skin_physiology0.86963213
94MP0002452_abnormal_antigen_presenting0.86928141
95MP0003448_altered_tumor_morphology0.85368345
96MP0001819_abnormal_immune_cell0.85016819
97MP0001849_ear_inflammation0.84543521
98MP0010630_abnormal_cardiac_muscle0.84052930
99MP0003115_abnormal_respiratory_system0.84042153
100MP0000428_abnormal_craniofacial_morphol0.83788950
101MP0004264_abnormal_extraembryonic_tissu0.80064070
102MP0000858_altered_metastatic_potential0.79546799
103MP0003119_abnormal_digestive_system0.78934468
104MP0002723_abnormal_immune_serum0.78485322
105MP0005621_abnormal_cell_physiology0.78087542
106MP0000432_abnormal_head_morphology0.77737206
107MP0001835_abnormal_antigen_presentation0.77678418
108MP0005666_abnormal_adipose_tissue0.75327948
109MP0003937_abnormal_limbs/digits/tail_de0.75011404
110MP0003935_abnormal_craniofacial_develop0.74757545
111MP0001216_abnormal_epidermal_layer0.74614157
112MP0005671_abnormal_response_to0.74536626
113MP0002697_abnormal_eye_size0.73509626
114MP0002060_abnormal_skin_morphology0.73117984
115MP0003436_decreased_susceptibility_to0.72961972
116MP0002009_preneoplasia0.72793031
117MP0003698_abnormal_male_reproductive0.72593612
118MP0001873_stomach_inflammation0.72406549
119MP0003718_maternal_effect0.72131160
120MP0004947_skin_inflammation0.71990328
121MP0005623_abnormal_meninges_morphology0.71332843
122MP0000627_abnormal_mammary_gland0.69876731
123MP0003699_abnormal_female_reproductive0.69482193
124MP0000003_abnormal_adipose_tissue0.68859747
125MP0003950_abnormal_plasma_membrane0.66166267
126MP0008260_abnormal_autophagy0.66145943
127MP0008995_early_reproductive_senescence0.63832129
128MP0001853_heart_inflammation0.63182998
129MP0000377_abnormal_hair_follicle0.62575227
130MP0000358_abnormal_cell_content/0.61385682
131MP0009931_abnormal_skin_appearance0.60074087

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.28377150
2Abnormality of the fingertips (HP:0001211)3.27459922
3Ependymoma (HP:0002888)3.03653021
4Nephroblastoma (Wilms tumor) (HP:0002667)2.91131385
5Medulloblastoma (HP:0002885)2.80705574
6Ankyloglossia (HP:0010296)2.76158659
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71883220
8Short 4th metacarpal (HP:0010044)2.71883220
9Embryonal renal neoplasm (HP:0011794)2.66998671
10Dysmetric saccades (HP:0000641)2.65101046
11Deviation of the thumb (HP:0009603)2.59444414
12Colon cancer (HP:0003003)2.53761591
13Basal cell carcinoma (HP:0002671)2.52149945
14Proximal placement of thumb (HP:0009623)2.50407815
15Increased nuchal translucency (HP:0010880)2.50027481
16Heterotopia (HP:0002282)2.49662560
17Selective tooth agenesis (HP:0001592)2.48891924
18Chromsome breakage (HP:0040012)2.47844334
19Prominent nose (HP:0000448)2.44793556
20Rhabdomyosarcoma (HP:0002859)2.43486900
21Birth length less than 3rd percentile (HP:0003561)2.41549833
22Abnormality of the astrocytes (HP:0100707)2.40040123
23Astrocytoma (HP:0009592)2.40040123
24Long eyelashes (HP:0000527)2.38210345
25Abnormality of chromosome stability (HP:0003220)2.37101905
26Increased density of long bones (HP:0006392)2.32961835
27Abnormality of oral frenula (HP:0000190)2.32563599
28Progressive external ophthalmoplegia (HP:0000590)2.31917884
29Asymmetry of the thorax (HP:0001555)2.28896284
30T lymphocytopenia (HP:0005403)2.28003918
31Ectopic kidney (HP:0000086)2.27021052
32Biliary tract neoplasm (HP:0100574)2.26743091
33Progressive muscle weakness (HP:0003323)2.24627613
34Papillary thyroid carcinoma (HP:0002895)2.24522346
35Acute myeloid leukemia (HP:0004808)2.23445145
36Neoplasm of the oral cavity (HP:0100649)2.22924511
37Facial hemangioma (HP:0000329)2.21823757
38Abnormality of chromosome segregation (HP:0002916)2.19781587
39High pitched voice (HP:0001620)2.16820114
40Uterine leiomyosarcoma (HP:0002891)2.15619755
41Leiomyosarcoma (HP:0100243)2.15619755
42Abnormality of the preputium (HP:0100587)2.15395460
43Absent frontal sinuses (HP:0002688)2.14055286
44Impulsivity (HP:0100710)2.12712237
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12094322
46Termporal pattern (HP:0011008)2.11754365
47Insidious onset (HP:0003587)2.11754365
48Sandal gap (HP:0001852)2.11630375
49Glioma (HP:0009733)2.11474269
50Abnormality of T cell number (HP:0011839)2.11430945
51Neoplasm of striated muscle (HP:0009728)2.10792712
52Relative macrocephaly (HP:0004482)2.09178663
53Malignant gastrointestinal tract tumors (HP:0006749)2.08665764
54Gastrointestinal carcinoma (HP:0002672)2.08665764
55Truncal obesity (HP:0001956)2.08344035
56Acute lymphatic leukemia (HP:0006721)2.06793156
57Myelodysplasia (HP:0002863)2.05461477
58Deep palmar crease (HP:0006191)2.05095670
59Agnosia (HP:0010524)2.04841320
60Recurrent bronchitis (HP:0002837)2.04549593
61Cortical dysplasia (HP:0002539)2.04465807
62Obsessive-compulsive behavior (HP:0000722)2.02958329
63Abnormality of the labia minora (HP:0012880)2.02784382
64Skull defect (HP:0001362)2.01243829
65Septate vagina (HP:0001153)1.98716534
66Broad palm (HP:0001169)1.96079315
67Subacute progressive viral hepatitis (HP:0006572)1.95625436
68Amaurosis fugax (HP:0100576)1.94835730
69Transitional cell carcinoma of the bladder (HP:0006740)1.94255737
70IgA deficiency (HP:0002720)1.93299239
71Abnormality of the distal phalanx of the thumb (HP:0009617)1.92062674
72Cafe-au-lait spot (HP:0000957)1.90573152
73Abnormal foot bone ossification (HP:0010675)1.89598067
74Cutaneous melanoma (HP:0012056)1.89043312
75Pelvic girdle muscle weakness (HP:0003749)1.88878140
76Abnormality of the 4th metacarpal (HP:0010012)1.88858608
77Cutis marmorata (HP:0000965)1.88320152
78Deep philtrum (HP:0002002)1.87224042
79Bladder neoplasm (HP:0009725)1.86023628
80Bladder carcinoma (HP:0002862)1.86023628
81Degeneration of anterior horn cells (HP:0002398)1.85734118
82Abnormality of the anterior horn cell (HP:0006802)1.85734118
83Limited elbow extension (HP:0001377)1.85265847
84Low anterior hairline (HP:0000294)1.85152800
85Fatigue (HP:0012378)1.84814794
86Orthostatic hypotension (HP:0001278)1.83601802
87Atresia of the external auditory canal (HP:0000413)1.83201154
88Aplasia/Hypoplasia of the sternum (HP:0006714)1.81813397
89Missing ribs (HP:0000921)1.81639179
90Viral hepatitis (HP:0006562)1.81569585
91Nasal polyposis (HP:0100582)1.81428085
92High anterior hairline (HP:0009890)1.81408041
93Embryonal neoplasm (HP:0002898)1.80686105
94Cerebral aneurysm (HP:0004944)1.79683329
95Trigonocephaly (HP:0000243)1.79001656
96Hematochezia (HP:0002573)1.78104890
97Supernumerary ribs (HP:0005815)1.77966811
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77776980
99Dislocated radial head (HP:0003083)1.77325269
10011 pairs of ribs (HP:0000878)1.76281353
101Urethral obstruction (HP:0000796)1.75569117
102Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74903398
103Short middle phalanx of the 5th finger (HP:0004220)1.74816740
104Bicuspid aortic valve (HP:0001647)1.74378152
105Hyperacusis (HP:0010780)1.73999066
106Multiple enchondromatosis (HP:0005701)1.73864990
107Abnormality of the salivary glands (HP:0010286)1.73815440
108Broad thumb (HP:0011304)1.73774477
109Patellar aplasia (HP:0006443)1.73145042
110Insomnia (HP:0100785)1.72909731
111Skin tags (HP:0010609)1.72733405
112Reticulocytopenia (HP:0001896)1.72453181
113Neonatal hypoglycemia (HP:0001998)1.71927249
114Recurrent viral infections (HP:0004429)1.71407308
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.67869224
116Thrombocytosis (HP:0001894)1.66571258
117Bowel incontinence (HP:0002607)1.66525566
118Renal cell carcinoma (HP:0005584)1.65753409
119Narrow palate (HP:0000189)1.65675575
120Macroorchidism (HP:0000053)1.65015978
121Meckel diverticulum (HP:0002245)1.64495924
122Abnormality of the radial head (HP:0003995)1.63726342
123Capillary hemangiomas (HP:0005306)1.63679750
124Duodenal stenosis (HP:0100867)1.63589291
125Small intestinal stenosis (HP:0012848)1.63589291
126Sparse lateral eyebrow (HP:0005338)1.63536656
127Disproportionate tall stature (HP:0001519)1.63220620
128Choanal atresia (HP:0000453)1.63183076
129Abnormality of the phalanges of the hallux (HP:0010057)1.62390943
130Supernumerary bones of the axial skeleton (HP:0009144)1.61800425
131Abnormal number of incisors (HP:0011064)1.61574905
132Abnormal large intestine physiology (HP:0012700)1.61542467
133Ulnar bowing (HP:0003031)1.61538044
134Cubitus valgus (HP:0002967)1.61535830
135Persistence of primary teeth (HP:0006335)1.61507423
136Abnormality of the left ventricular outflow tract (HP:0011103)1.61277807
137Subaortic stenosis (HP:0001682)1.61277807
138Shallow orbits (HP:0000586)1.61257266
139Flat acetabular roof (HP:0003180)1.60654462
140Abnormality of the calcaneus (HP:0008364)1.60450876
141Rectal prolapse (HP:0002035)1.60146528
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59404129
143Squamous cell carcinoma (HP:0002860)1.58416411
144Overlapping toe (HP:0001845)1.57814250
145Aplasia/Hypoplasia of the patella (HP:0006498)1.57613432
146Abnormality of T cells (HP:0002843)1.57411140
147Syringomyelia (HP:0003396)1.56955577
148Spinal cord lesions (HP:0100561)1.56955577
149Abnormality of the carotid arteries (HP:0005344)1.56154220
150Blepharitis (HP:0000498)1.55737611
151Abnormality of the ileum (HP:0001549)1.55062601
152Short 1st metacarpal (HP:0010034)1.54786636
153Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.54786636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.33600805
2CDC74.11206178
3SMG13.11421224
4EEF2K3.10893949
5NEK22.75853923
6PRPF4B2.61307005
7PKN22.28760959
8MAP3K102.28643966
9STK102.28401871
10WEE12.20666686
11MAP4K12.13831416
12BRD41.81614777
13TTK1.73556447
14LATS11.73312057
15RPS6KB21.71521139
16ACVR1B1.69768039
17CDK41.66496717
18RPS6KA41.62146486
19ATR1.57489577
20CDK61.55780719
21PASK1.53109192
22KSR21.51441675
23TSSK61.50752269
24STK31.49492480
25ALK1.37440508
26TGFBR11.36326580
27SCYL21.35583007
28* CHEK11.35409152
29MAP3K81.31573803
30SRPK11.29026422
31TRIB31.27246063
32CLK11.26717843
33JAK31.26530393
34EIF2AK31.24655558
35MAP3K141.23723015
36TTN1.23293286
37PIM11.23030077
38MKNK11.21821120
39CDK71.20255825
40AURKB1.19818339
41CHEK21.18144593
42MELK1.17804694
43MTOR1.17203234
44PLK11.16503219
45ATM1.15807553
46STK41.12445746
47FGFR31.10889121
48TAF11.10361304
49IRAK31.09190743
50LRRK21.06085996
51MAP3K21.00836106
52BRSK20.98899050
53MKNK20.98646956
54EIF2AK10.97561735
55PLK30.96940542
56PBK0.96522254
57PLK40.95090765
58FLT30.94391850
59TXK0.93589718
60ITK0.92733634
61PTK60.92200611
62EPHA20.91778612
63CDK90.91150974
64MAP3K130.90787680
65* CDK20.90533606
66LATS20.90283195
67DYRK30.88704984
68ZAP700.85242518
69WNK10.85198187
70NEK10.85172266
71TLK10.82545098
72RAF10.81832085
73RIPK10.81273496
74KSR10.80621290
75GRK60.80405842
76MAP2K30.80390569
77CAMK1D0.80144841
78BUB10.78730813
79ICK0.76735145
80FGFR40.76502484
81MARK30.75339399
82PAK40.74668523
83CHUK0.72950021
84BRAF0.72640551
85PDK40.71391007
86PDK30.71391007
87MAPK110.71263180
88PAK20.71155178
89FGFR10.69857040
90BRSK10.68118300
91PDGFRB0.67197934
92TYK20.66948957
93YES10.66408426
94CDK10.64610401
95PNCK0.64158146
96PDGFRA0.62814134
97NLK0.62232893
98CSNK1D0.61011504
99RIPK40.59220750
100BTK0.57844513
101CDK80.57544737
102EIF2AK20.54747673
103TESK10.54494612
104AURKA0.54373230
105RPS6KA50.53772427
106TRPM70.50291754
107STK240.49511193
108LCK0.49041441
109MST1R0.49033568
110PRKDC0.48989649
111MAP3K30.48503592
112TAOK20.48134979
113BMX0.46950972
114CSF1R0.45977300
115TYRO30.45925093
116CAMK1G0.45351660
117HCK0.45162020
118MAP3K90.44882272
119MAPK140.43599181
120NEK60.43158852
121SGK30.42956596
122MAP3K10.42469072
123MAPK100.42223767
124CSK0.41974756
125AKT30.41163059
126BMPR20.41103450
127SIK30.41016862
128TEC0.40515938
129DMPK0.40349773
130CSNK2A20.40146330
131RPS6KB10.39977597
132RET0.39915020
133NEK90.39690232
134NME20.38102039
135TGFBR20.37469309
136* MAPK10.37433384
137JAK10.36382920
138FGFR20.36124106
139SIK10.35894962
140CSNK1E0.35855032
141GSK3B0.34266432
142AKT20.34162178

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.09024535
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68596370
3Mismatch repair_Homo sapiens_hsa034302.68244190
4* RNA transport_Homo sapiens_hsa030132.64407631
5Cell cycle_Homo sapiens_hsa041102.56317718
6Spliceosome_Homo sapiens_hsa030402.41733760
7One carbon pool by folate_Homo sapiens_hsa006702.07991511
8mRNA surveillance pathway_Homo sapiens_hsa030152.06260267
9Base excision repair_Homo sapiens_hsa034101.78594683
10Fanconi anemia pathway_Homo sapiens_hsa034601.77720093
11Systemic lupus erythematosus_Homo sapiens_hsa053221.74360086
12Nucleotide excision repair_Homo sapiens_hsa034201.73032470
13Homologous recombination_Homo sapiens_hsa034401.69960480
14Non-homologous end-joining_Homo sapiens_hsa034501.64018674
15Viral carcinogenesis_Homo sapiens_hsa052031.63918027
16Antigen processing and presentation_Homo sapiens_hsa046121.60445990
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59333769
18RNA degradation_Homo sapiens_hsa030181.58967685
19p53 signaling pathway_Homo sapiens_hsa041151.58419353
20Herpes simplex infection_Homo sapiens_hsa051681.50974242
21MicroRNAs in cancer_Homo sapiens_hsa052061.43700479
22Primary immunodeficiency_Homo sapiens_hsa053401.42882798
23Chronic myeloid leukemia_Homo sapiens_hsa052201.36991275
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35809245
25HTLV-I infection_Homo sapiens_hsa051661.35462997
26Small cell lung cancer_Homo sapiens_hsa052221.34108455
27Basal transcription factors_Homo sapiens_hsa030221.28056644
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.26977687
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25545268
30T cell receptor signaling pathway_Homo sapiens_hsa046601.24511361
31Measles_Homo sapiens_hsa051621.18868072
32Glioma_Homo sapiens_hsa052141.17843079
33Epstein-Barr virus infection_Homo sapiens_hsa051691.17161242
34Colorectal cancer_Homo sapiens_hsa052101.16366297
35Adherens junction_Homo sapiens_hsa045201.14442654
36mTOR signaling pathway_Homo sapiens_hsa041501.13839218
37B cell receptor signaling pathway_Homo sapiens_hsa046621.10726118
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10059275
39ErbB signaling pathway_Homo sapiens_hsa040121.09369443
40Viral myocarditis_Homo sapiens_hsa054161.09179797
41Hepatitis B_Homo sapiens_hsa051611.05205992
42TGF-beta signaling pathway_Homo sapiens_hsa043501.01366998
43Thyroid cancer_Homo sapiens_hsa052161.00786874
44Lysine degradation_Homo sapiens_hsa003101.00430832
45Acute myeloid leukemia_Homo sapiens_hsa052210.99370196
46Oocyte meiosis_Homo sapiens_hsa041140.95474485
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94926763
48Pancreatic cancer_Homo sapiens_hsa052120.94321223
49Inositol phosphate metabolism_Homo sapiens_hsa005620.92940288
50Notch signaling pathway_Homo sapiens_hsa043300.92892065
51Toxoplasmosis_Homo sapiens_hsa051450.92177890
52Prostate cancer_Homo sapiens_hsa052150.89995647
53Osteoclast differentiation_Homo sapiens_hsa043800.88940331
54Leishmaniasis_Homo sapiens_hsa051400.88342837
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85511531
56Apoptosis_Homo sapiens_hsa042100.85127017
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83641520
58Influenza A_Homo sapiens_hsa051640.83040821
59Hippo signaling pathway_Homo sapiens_hsa043900.82959072
60Dorso-ventral axis formation_Homo sapiens_hsa043200.82929302
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82870693
62Proteoglycans in cancer_Homo sapiens_hsa052050.82726193
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.81454053
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.81062780
65Pyrimidine metabolism_Homo sapiens_hsa002400.80634841
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80548733
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80194200
68Legionellosis_Homo sapiens_hsa051340.79892972
69RNA polymerase_Homo sapiens_hsa030200.79845863
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79760491
71Non-small cell lung cancer_Homo sapiens_hsa052230.79326021
72Insulin signaling pathway_Homo sapiens_hsa049100.78960391
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77830879
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77032301
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.76757204
76Hematopoietic cell lineage_Homo sapiens_hsa046400.76566279
77Ribosome_Homo sapiens_hsa030100.75742283
78Selenocompound metabolism_Homo sapiens_hsa004500.75247366
79Basal cell carcinoma_Homo sapiens_hsa052170.75223503
80Endometrial cancer_Homo sapiens_hsa052130.75000075
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74418601
82Biosynthesis of amino acids_Homo sapiens_hsa012300.72937149
83Hepatitis C_Homo sapiens_hsa051600.72740454
84TNF signaling pathway_Homo sapiens_hsa046680.70483060
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70252841
86FoxO signaling pathway_Homo sapiens_hsa040680.67793511
87Pathways in cancer_Homo sapiens_hsa052000.67658927
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67649233
89Alcoholism_Homo sapiens_hsa050340.67428348
90Choline metabolism in cancer_Homo sapiens_hsa052310.67235661
91Pentose phosphate pathway_Homo sapiens_hsa000300.65213377
92Shigellosis_Homo sapiens_hsa051310.63914180
93HIF-1 signaling pathway_Homo sapiens_hsa040660.62717823
94Melanoma_Homo sapiens_hsa052180.62200090
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.61517173
96Focal adhesion_Homo sapiens_hsa045100.60335768
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59787943
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.59694010
99Platelet activation_Homo sapiens_hsa046110.59079502
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58578361
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57745726
102Renal cell carcinoma_Homo sapiens_hsa052110.56029015
103Prolactin signaling pathway_Homo sapiens_hsa049170.55664659
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53720324
105AMPK signaling pathway_Homo sapiens_hsa041520.52742517
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50471471
107VEGF signaling pathway_Homo sapiens_hsa043700.50461106
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49529564
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.49023427
110Wnt signaling pathway_Homo sapiens_hsa043100.48656198
111Bladder cancer_Homo sapiens_hsa052190.48365734
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44972162
113Insulin resistance_Homo sapiens_hsa049310.44652321
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44585327
115Allograft rejection_Homo sapiens_hsa053300.42085043
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.40912775
117Estrogen signaling pathway_Homo sapiens_hsa049150.40210374
118Type II diabetes mellitus_Homo sapiens_hsa049300.37817024

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