NUMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)4.63563199
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.97803001
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.97803001
4endothelial cell chemotaxis (GO:0035767)3.86122610
5peptidyl-lysine dimethylation (GO:0018027)3.81642185
6pre-miRNA processing (GO:0031054)3.77017290
7regulation of gamma-delta T cell differentiation (GO:0045586)3.70917199
8semaphorin-plexin signaling pathway (GO:0071526)3.63212154
9glucocorticoid receptor signaling pathway (GO:0042921)3.55217911
10negative regulation of histone methylation (GO:0031061)3.48934690
11positive thymic T cell selection (GO:0045059)3.48598122
12mannose metabolic process (GO:0006013)3.45627110
13antigen processing and presentation of endogenous antigen (GO:0019883)3.44868136
14cytoplasmic mRNA processing body assembly (GO:0033962)3.41754993
15positive regulation of gamma-delta T cell activation (GO:0046645)3.41264170
16regulation of ARF protein signal transduction (GO:0032012)3.40945205
17regulation of histone H3-K27 methylation (GO:0061085)3.40635658
18positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.38067603
19nuclear pore complex assembly (GO:0051292)3.35753600
20positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.33287945
21regulation of RNA export from nucleus (GO:0046831)3.25423732
22regulation of glucose import in response to insulin stimulus (GO:2001273)3.23331758
23positive regulation of protein deacetylation (GO:0090312)3.23002970
24DNA unwinding involved in DNA replication (GO:0006268)3.21252725
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.21094307
26regulation of gamma-delta T cell activation (GO:0046643)3.19181994
27regulation of NFAT protein import into nucleus (GO:0051532)3.16338984
28antigen processing and presentation via MHC class Ib (GO:0002475)3.16130403
29peptidyl-tyrosine autophosphorylation (GO:0038083)3.15167835
30negative regulation of erythrocyte differentiation (GO:0045647)3.13130707
31negative regulation of fatty acid transport (GO:2000192)3.12361720
32mRNA stabilization (GO:0048255)3.09379846
33RNA stabilization (GO:0043489)3.09379846
34histone H3-K36 demethylation (GO:0070544)3.06194444
35nuclear pore organization (GO:0006999)3.05751787
36insulin-like growth factor receptor signaling pathway (GO:0048009)3.02860712
37regulation of translational fidelity (GO:0006450)3.02496918
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98298932
39mitotic sister chromatid cohesion (GO:0007064)2.96213198
40NLS-bearing protein import into nucleus (GO:0006607)2.95543712
41dosage compensation (GO:0007549)2.92048446
42corticosteroid receptor signaling pathway (GO:0031958)2.91340251
43regulation of ARF GTPase activity (GO:0032312)2.91068560
44positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.89851729
45negative regulation of cell size (GO:0045792)2.88150874
46embryonic camera-type eye morphogenesis (GO:0048596)2.82573680
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81863217
48cell-cell junction maintenance (GO:0045217)2.81473443
49thymic T cell selection (GO:0045061)2.79784098
50heterochromatin organization (GO:0070828)2.76329571
51epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75515063
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73422208
53activation of Rac GTPase activity (GO:0032863)2.73032721
54regulation of nucleobase-containing compound transport (GO:0032239)2.71336631
55ear development (GO:0043583)2.69828322
56embryonic eye morphogenesis (GO:0048048)2.69084551
57mitotic chromosome condensation (GO:0007076)2.68904322
58COPI coating of Golgi vesicle (GO:0048205)2.68872127
59Golgi transport vesicle coating (GO:0048200)2.68872127
60histone demethylation (GO:0016577)2.68412566
61negative regulation of myotube differentiation (GO:0010832)2.66089134
62cytoskeletal anchoring at plasma membrane (GO:0007016)2.66038747
63regulation of histone H3-K9 methylation (GO:0051570)2.64520711
64DNA duplex unwinding (GO:0032508)2.63588239
65apoptotic process involved in morphogenesis (GO:0060561)2.63234076
66positive T cell selection (GO:0043368)2.60988572
67DNA geometric change (GO:0032392)2.60531408
68adherens junction assembly (GO:0034333)2.60489627
69regulation of sister chromatid cohesion (GO:0007063)2.60310066
70positive regulation of gene expression, epigenetic (GO:0045815)2.58705958
71cell-substrate junction assembly (GO:0007044)2.56454481
72germ cell migration (GO:0008354)2.55850817
73positive regulation of RNA splicing (GO:0033120)2.54093066
74negative regulation of RNA splicing (GO:0033119)2.53780004
75protein localization to kinetochore (GO:0034501)2.53599648
76activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53429695
77positive regulation of SMAD protein import into nucleus (GO:0060391)2.53153328
78negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.53116466
79positive regulation of nuclease activity (GO:0032075)2.51561928
80barbed-end actin filament capping (GO:0051016)2.51254460
81protein localization to endosome (GO:0036010)2.51184367
82retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51044417
83embryonic process involved in female pregnancy (GO:0060136)2.50850889
84embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50748299
85histone H3-K4 methylation (GO:0051568)2.50521834
86regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.50364427
87natural killer cell differentiation (GO:0001779)2.50305634
88cellular response to epidermal growth factor stimulus (GO:0071364)2.49783501
89histone H3-K9 demethylation (GO:0033169)2.49309720
90chromatin assembly (GO:0031497)2.48993110
91epithelial cell-cell adhesion (GO:0090136)2.48982806
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.46750573
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.43948682
94nucleosome disassembly (GO:0006337)2.42705477
95protein-DNA complex disassembly (GO:0032986)2.42705477
96cell volume homeostasis (GO:0006884)2.42295447
97eye morphogenesis (GO:0048592)2.41761454
98regulation of mRNA stability (GO:0043488)2.40899818
99vascular endothelial growth factor signaling pathway (GO:0038084)2.40655368
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.40142308
101growth hormone receptor signaling pathway (GO:0060396)2.39428955
102desmosome organization (GO:0002934)2.39382177
103pore complex assembly (GO:0046931)2.39217857
104positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38963373
105gene silencing (GO:0016458)2.38657000
106alternative mRNA splicing, via spliceosome (GO:0000380)2.37754674
107regulation of histone deacetylation (GO:0031063)2.37345791
108coronary vasculature morphogenesis (GO:0060977)2.36924515
109T cell selection (GO:0045058)2.35142533
110histone H4-K16 acetylation (GO:0043984)2.35021485
111sister chromatid segregation (GO:0000819)2.34656677
112regulation of extracellular matrix disassembly (GO:0010715)2.34506813
113histone lysine demethylation (GO:0070076)2.34253412
1143-UTR-mediated mRNA stabilization (GO:0070935)2.33859628
115positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33628845
116regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.33605276
117regulation of fatty acid beta-oxidation (GO:0031998)2.33600096
118hippo signaling (GO:0035329)2.33569896
119cell-substrate adherens junction assembly (GO:0007045)2.33141022
120focal adhesion assembly (GO:0048041)2.33141022
121negative regulation of mRNA metabolic process (GO:1903312)2.32946631
122histone H2A monoubiquitination (GO:0035518)2.32772207
123negative regulation of gene expression, epigenetic (GO:0045814)2.32308043
124camera-type eye morphogenesis (GO:0048593)2.32136385
125morphogenesis of an endothelium (GO:0003159)2.32097650
126endothelial tube morphogenesis (GO:0061154)2.32097650
127response to laminar fluid shear stress (GO:0034616)2.31728025
128basement membrane organization (GO:0071711)2.31297616
129regulation of nuclease activity (GO:0032069)2.30943441
130response to epidermal growth factor (GO:0070849)2.30871188
131maternal placenta development (GO:0001893)2.30380932
132atrioventricular valve morphogenesis (GO:0003181)2.30337466
133negative thymic T cell selection (GO:0045060)2.30206810
134chromatin silencing (GO:0006342)2.29944305
135activation of JUN kinase activity (GO:0007257)2.28407835
136protein dealkylation (GO:0008214)2.28048415
137protein demethylation (GO:0006482)2.28048415
138protein retention in ER lumen (GO:0006621)2.27883435
139negative regulation of histone modification (GO:0031057)2.27689866
140histone H3-K4 trimethylation (GO:0080182)2.27118559
141regulation of histone H3-K4 methylation (GO:0051569)2.24971365
142JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.24885834
143receptor catabolic process (GO:0032801)2.24722928
144negative T cell selection (GO:0043383)2.24667259
145trophectodermal cell differentiation (GO:0001829)2.24518883
146positive regulation of receptor recycling (GO:0001921)2.24488630
147apoptotic cell clearance (GO:0043277)2.24233960
148intracellular estrogen receptor signaling pathway (GO:0030520)2.23889453
149regulation of RNA stability (GO:0043487)2.23444389
150histone lysine methylation (GO:0034968)2.23020593
151histone H4 deacetylation (GO:0070933)2.22646216
152regulation of mitotic spindle organization (GO:0060236)2.22538604
153protein targeting to plasma membrane (GO:0072661)2.21642870
154vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.19503372
155branching involved in mammary gland duct morphogenesis (GO:0060444)2.18083861
156stress granule assembly (GO:0034063)2.18075595
157regulation of endothelial cell chemotaxis (GO:2001026)2.17338591
158peptidyl-threonine modification (GO:0018210)2.13320312
159regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.12855813
160peptidyl-threonine phosphorylation (GO:0018107)2.11803757
161stress fiber assembly (GO:0043149)2.11361822
162actin filament capping (GO:0051693)2.11151581
163myelin maintenance (GO:0043217)2.10952279
164cortical actin cytoskeleton organization (GO:0030866)2.09326617
165negative regulation of viral release from host cell (GO:1902187)2.08565211
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.08501527
167regulation of chromatin binding (GO:0035561)2.07615706
168maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.07046246
169positive regulation of Rac GTPase activity (GO:0032855)2.06998794
170hemidesmosome assembly (GO:0031581)2.06828067
171actin cytoskeleton reorganization (GO:0031532)2.06258436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12224621
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.19581663
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.04223608
4MYC_22102868_ChIP-Seq_BL_Human3.90529513
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.87847855
6VDR_21846776_ChIP-Seq_THP-1_Human2.71457529
7* TCF7_22412390_ChIP-Seq_EML_Mouse2.69407982
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67689166
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55675895
10KDM2B_26808549_Chip-Seq_DND41_Human2.42562344
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.35467326
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.27930960
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18276828
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.15031527
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08770565
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05708451
17SCL_19346495_ChIP-Seq_HPC-7_Human2.02487142
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.00055029
19UTX_26944678_Chip-Seq_JUKART_Human1.97450351
20MAF_26560356_Chip-Seq_TH1_Human1.93346298
21CLOCK_20551151_ChIP-Seq_293T_Human1.90530717
22CIITA_25753668_ChIP-Seq_RAJI_Human1.84483837
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82310632
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81872339
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79916376
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78310823
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77022092
28DROSHA_22980978_ChIP-Seq_HELA_Human1.75448294
29* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72334884
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72225834
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.67699474
32SMC4_20622854_ChIP-Seq_HELA_Human1.64373276
33* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63988067
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.63010839
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56393871
36VDR_24763502_ChIP-Seq_THP-1_Human1.55928104
37* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55057245
38ZNF263_19887448_ChIP-Seq_K562_Human1.53670256
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50667625
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.49596222
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.48470938
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48285704
43MYB_26560356_Chip-Seq_TH1_Human1.47791391
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47052628
45NCOR1_26117541_ChIP-Seq_K562_Human1.46204901
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44857570
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44482009
48* MYB_26560356_Chip-Seq_TH2_Human1.43051536
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41895188
50RUNX_20019798_ChIP-Seq_JUKART_Human1.40238477
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39337311
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39180073
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38901462
54P68_20966046_ChIP-Seq_HELA_Human1.38773159
55LXR_22292898_ChIP-Seq_THP-1_Human1.37272621
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36574103
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35803858
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35379937
59RACK7_27058665_Chip-Seq_MCF-7_Human1.35313948
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.34683713
61SPI1_23127762_ChIP-Seq_K562_Human1.34304900
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32489906
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32366740
64FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31460624
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31226409
66* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30954956
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28684474
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.27281484
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27094690
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26414026
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25846436
72KDM2B_26808549_Chip-Seq_K562_Human1.25652622
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.23623498
74* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22981788
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20961498
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20485618
77ATF3_27146783_Chip-Seq_COLON_Human1.18091630
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17637735
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16873895
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.16382628
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.16205693
82GATA1_19941826_ChIP-Seq_K562_Human1.16044869
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15596635
84CTCF_27219007_Chip-Seq_Bcells_Human1.15359082
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15200682
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.15142999
87* E2F1_21310950_ChIP-Seq_MCF-7_Human1.14577378
88GATA1_22025678_ChIP-Seq_K562_Human1.14090537
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13850456
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13815622
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13540987
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13279081
93MAF_26560356_Chip-Seq_TH2_Human1.13082901
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12224750
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11997053
96GATA6_25053715_ChIP-Seq_YYC3_Human1.11992226
97TP53_22127205_ChIP-Seq_IMR90_Human1.11828396
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11399230
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.09859377
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09658524
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09279416
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08907866
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08344816
104* CHD1_26751641_Chip-Seq_LNCaP_Human1.08311627
105CREB1_26743006_Chip-Seq_LNCaP_Human1.06430843
106FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05763053
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05408632
108* TP63_22573176_ChIP-Seq_HFKS_Human1.05100391
109AR_21909140_ChIP-Seq_LNCAP_Human1.04925285
110PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04286530
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.03182981
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.03182981
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02752797
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02185343
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01414488
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00513053
117UBF1/2_26484160_Chip-Seq_HMECs_Human1.00507295
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99707493
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99424900
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.98615748
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98541868
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97817020
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97539119
124RARB_27405468_Chip-Seq_BRAIN_Mouse0.97282670
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97160456
126TP53_23651856_ChIP-Seq_MEFs_Mouse0.96937513
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.94730142
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93896667
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92881446
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92566025
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92338263
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92266652
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91751155
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91479202
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91473660
136KLF5_25053715_ChIP-Seq_YYC3_Human0.91146865
137* TET1_21490601_ChIP-Seq_MESCs_Mouse0.91071273
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90963626
139* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90803567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.25694619
2MP0002009_preneoplasia3.19242761
3MP0003300_gastrointestinal_ulcer3.03333857
4MP0010352_gastrointestinal_tract_polyps2.98158594
5MP0005076_abnormal_cell_differentiation2.95674431
6MP0004858_abnormal_nervous_system2.75056951
7MP0010234_abnormal_vibrissa_follicle2.73513603
8MP0005409_darkened_coat_color2.63711203
9MP0009278_abnormal_bone_marrow2.56167874
10MP0002396_abnormal_hematopoietic_system2.09656218
11MP0003566_abnormal_cell_adhesion2.09542918
12MP0002877_abnormal_melanocyte_morpholog2.06446381
13MP0000569_abnormal_digit_pigmentation2.06076826
14MP0008961_abnormal_basal_metabolism2.05897586
15MP0004808_abnormal_hematopoietic_stem2.05339576
16MP0001348_abnormal_lacrimal_gland1.98203976
17MP0005451_abnormal_body_composition1.93199097
18MP0002166_altered_tumor_susceptibility1.90520644
19MP0002249_abnormal_larynx_morphology1.88794477
20MP0001849_ear_inflammation1.87102628
21MP0005058_abnormal_lysosome_morphology1.81817524
22MP0010307_abnormal_tumor_latency1.80941879
23MP0000733_abnormal_muscle_development1.64946583
24MP0004381_abnormal_hair_follicle1.62884051
25MP0006054_spinal_hemorrhage1.59458515
26MP0000537_abnormal_urethra_morphology1.58172076
27MP0000678_abnormal_parathyroid_gland1.52888327
28MP0002796_impaired_skin_barrier1.52434120
29MP0003763_abnormal_thymus_physiology1.49788453
30MP0004185_abnormal_adipocyte_glucose1.49613044
31MP0004197_abnormal_fetal_growth/weight/1.41123842
32MP0000566_synostosis1.40589287
33MP0001545_abnormal_hematopoietic_system1.40205267
34MP0005397_hematopoietic_system_phenotyp1.40205267
35MP0003283_abnormal_digestive_organ1.36497735
36MP0003172_abnormal_lysosome_physiology1.35396201
37MP0005023_abnormal_wound_healing1.34228191
38MP0001730_embryonic_growth_arrest1.33448186
39MP0003303_peritoneal_inflammation1.32910352
40MP0005666_abnormal_adipose_tissue1.32717941
41MP0008260_abnormal_autophagy1.31474030
42MP0003045_fibrosis1.31420078
43MP0000751_myopathy1.30562187
44MP0005670_abnormal_white_adipose1.30474637
45MP0000703_abnormal_thymus_morphology1.29822520
46MP0000685_abnormal_immune_system1.29093014
47MP0003984_embryonic_growth_retardation1.29055891
48MP0002088_abnormal_embryonic_growth/wei1.28954959
49MP0002086_abnormal_extraembryonic_tissu1.27707587
50MP0003111_abnormal_nucleus_morphology1.27626754
51MP0002108_abnormal_muscle_morphology1.27443744
52MP0005503_abnormal_tendon_morphology1.26190702
53MP0010630_abnormal_cardiac_muscle1.25505106
54MP0002084_abnormal_developmental_patter1.24180787
55MP0009780_abnormal_chondrocyte_physiolo1.22544737
56MP0005380_embryogenesis_phenotype1.22342925
57MP0001672_abnormal_embryogenesis/_devel1.22342925
58MP0003091_abnormal_cell_migration1.20269518
59MP0008438_abnormal_cutaneous_collagen1.19692578
60MP0005375_adipose_tissue_phenotype1.19517036
61MP0002822_catalepsy1.18168347
62MP0004264_abnormal_extraembryonic_tissu1.16688293
63MP0001873_stomach_inflammation1.16672210
64MP0002896_abnormal_bone_mineralization1.14672294
65MP0002925_abnormal_cardiovascular_devel1.14075122
66MP0003115_abnormal_respiratory_system1.13758593
67MP0002006_tumorigenesis1.13313192
68MP0004947_skin_inflammation1.13247716
69MP0002089_abnormal_postnatal_growth/wei1.13038454
70* MP0003077_abnormal_cell_cycle1.12474770
71MP0000003_abnormal_adipose_tissue1.11721112
72MP0000428_abnormal_craniofacial_morphol1.11686429
73MP0002398_abnormal_bone_marrow1.10885127
74* MP0000350_abnormal_cell_proliferation1.10640326
75MP0003329_amyloid_beta_deposits1.10570988
76MP0005257_abnormal_intraocular_pressure1.10008280
77MP0004233_abnormal_muscle_weight1.09937095
78MP0003279_aneurysm1.09093931
79MP0003123_paternal_imprinting1.08770071
80MP0003866_abnormal_defecation1.08504222
81MP0010094_abnormal_chromosome_stability1.07574213
82MP0006138_congestive_heart_failure1.07272110
83MP0000465_gastrointestinal_hemorrhage1.05267102
84MP0000462_abnormal_digestive_system1.03785193
85MP0000534_abnormal_ureter_morphology1.03568672
86MP0002085_abnormal_embryonic_tissue1.02651935
87MP0001697_abnormal_embryo_size1.02145353
88MP0008007_abnormal_cellular_replicative1.01756458
89MP0001915_intracranial_hemorrhage1.00849620
90MP0002928_abnormal_bile_duct1.00349864
91MP0000747_muscle_weakness0.99294780
92MP0003879_abnormal_hair_cell0.99033761
93* MP0002080_prenatal_lethality0.96270545
94MP0002722_abnormal_immune_system0.94269652
95MP0010155_abnormal_intestine_physiology0.94090466
96MP0003191_abnormal_cellular_cholesterol0.93773725
97MP0003567_abnormal_fetal_cardiomyocyte0.93718965
98MP0000266_abnormal_heart_morphology0.93508388
99MP0000490_abnormal_crypts_of0.92967603
100MP0003183_abnormal_peptide_metabolism0.91204876
101MP0004084_abnormal_cardiac_muscle0.90884035
102MP0002998_abnormal_bone_remodeling0.89367288
103MP0005621_abnormal_cell_physiology0.88881822
104MP0002098_abnormal_vibrissa_morphology0.88222026
105MP0009053_abnormal_anal_canal0.88072658
106MP0010678_abnormal_skin_adnexa0.87632034
107MP0003121_genomic_imprinting0.87502327
108MP0005310_abnormal_salivary_gland0.87374583
109MP0003634_abnormal_glial_cell0.86771303
110MP0000681_abnormal_thyroid_gland0.86267751
111MP0009703_decreased_birth_body0.86205228
112MP0004130_abnormal_muscle_cell0.85973863
113MP0001800_abnormal_humoral_immune0.85485922
114MP0004087_abnormal_muscle_fiber0.85347671
115MP0000477_abnormal_intestine_morphology0.85068392
116MP0003935_abnormal_craniofacial_develop0.84952223
117MP0009672_abnormal_birth_weight0.84715321
118MP0009384_cardiac_valve_regurgitation0.83646388
119MP0000767_abnormal_smooth_muscle0.83122841
120MP0000689_abnormal_spleen_morphology0.82254049
121MP0002234_abnormal_pharynx_morphology0.82202630
122MP0005501_abnormal_skin_physiology0.82061009
123MP0002060_abnormal_skin_morphology0.81798082
124MP0000759_abnormal_skeletal_muscle0.80783926
125MP0002092_abnormal_eye_morphology0.80208174
126MP0001784_abnormal_fluid_regulation0.79939598
127MP0002128_abnormal_blood_circulation0.79517086
128MP0003828_pulmonary_edema0.77939097
129MP0005275_abnormal_skin_tensile0.77356047
130MP0004957_abnormal_blastocyst_morpholog0.76953136
131MP0002019_abnormal_tumor_incidence0.76767836
132MP0001958_emphysema0.76351609
133MP0004859_abnormal_synaptic_plasticity0.75959805
134MP0009115_abnormal_fat_cell0.75841726
135MP0000716_abnormal_immune_system0.75498187
136MP0010368_abnormal_lymphatic_system0.75120347
137MP0008057_abnormal_DNA_replication0.74905223
138MP0000371_diluted_coat_color0.74496333
139MP0003942_abnormal_urinary_system0.74475824
140MP0004272_abnormal_basement_membrane0.73692151
141MP0009931_abnormal_skin_appearance0.73200614
142MP0004036_abnormal_muscle_relaxation0.73110072
143MP0002429_abnormal_blood_cell0.72736363
144MP0003453_abnormal_keratinocyte_physiol0.72361643
145MP0003690_abnormal_glial_cell0.72125320
146MP0002116_abnormal_craniofacial_bone0.70590468
147MP0000377_abnormal_hair_follicle0.70298629
148MP0004510_myositis0.69956221
149MP0002933_joint_inflammation0.68384840
150MP0004782_abnormal_surfactant_physiolog0.68027471
151MP0000627_abnormal_mammary_gland0.67615494
152MP0002970_abnormal_white_adipose0.66870603
153MP0009840_abnormal_foam_cell0.65962979
154MP0001502_abnormal_circadian_rhythm0.64462199
155MP0003315_abnormal_perineum_morphology0.63833498

Predicted human phenotypes

RankGene SetZ-score
1Broad face (HP:0000283)4.12771026
2Abnormality of the fingertips (HP:0001211)3.96431775
3Obstructive sleep apnea (HP:0002870)3.96245762
4Cerebral aneurysm (HP:0004944)3.88745880
5Hyperacusis (HP:0010780)3.70036352
6Flat acetabular roof (HP:0003180)3.09032552
7Short 4th metacarpal (HP:0010044)3.05011452
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.05011452
9Macroorchidism (HP:0000053)2.96139622
10Aortic aneurysm (HP:0004942)2.83201654
11Abnormality of the distal phalanx of the thumb (HP:0009617)2.69629095
12Shallow orbits (HP:0000586)2.67196449
13Hematochezia (HP:0002573)2.60897045
14Cervical subluxation (HP:0003308)2.55547515
15Aneurysm (HP:0002617)2.53764099
16Renal duplication (HP:0000075)2.52124492
17Bronchomalacia (HP:0002780)2.49861813
18Abnormality of the 4th metacarpal (HP:0010012)2.48587979
19Elfin facies (HP:0004428)2.48014788
20Germ cell neoplasia (HP:0100728)2.41174214
21Rectal prolapse (HP:0002035)2.40854303
22Subacute progressive viral hepatitis (HP:0006572)2.39795621
23Renovascular hypertension (HP:0100817)2.35605912
24Ankle contracture (HP:0006466)2.30700586
25Broad metatarsal (HP:0001783)2.29908793
26Ulnar bowing (HP:0003031)2.28714694
27Long eyelashes (HP:0000527)2.27060488
28Mitral valve prolapse (HP:0001634)2.27003215
29Increased nuchal translucency (HP:0010880)2.26448530
30Enlarged penis (HP:0000040)2.25943536
31Ependymoma (HP:0002888)2.25690826
32Dysmetric saccades (HP:0000641)2.24628784
33Bowel diverticulosis (HP:0005222)2.24504429
34Asymmetry of the thorax (HP:0001555)2.22856310
35Increased density of long bones (HP:0006392)2.19184997
36Volvulus (HP:0002580)2.16495773
37Lymphangioma (HP:0100764)2.14607953
38Advanced eruption of teeth (HP:0006288)2.12372088
39Protrusio acetabuli (HP:0003179)2.11810165
40Distal lower limb amyotrophy (HP:0008944)2.10697836
41Sparse lateral eyebrow (HP:0005338)2.10393855
42Narrow palate (HP:0000189)2.10088195
43Heterotopia (HP:0002282)2.08471151
44High pitched voice (HP:0001620)2.08224423
45Urethral obstruction (HP:0000796)2.07364735
46Broad palm (HP:0001169)2.03431316
47Precocious puberty (HP:0000826)2.03022858
48Persistence of primary teeth (HP:0006335)2.01535674
49Dilatation of the ascending aorta (HP:0005111)1.97734276
50Biconcave vertebral bodies (HP:0004586)1.96531170
51Bladder diverticulum (HP:0000015)1.96461280
52Bicuspid aortic valve (HP:0001647)1.96353113
53Thin bony cortex (HP:0002753)1.95146975
54Insomnia (HP:0100785)1.93682819
55Radial bowing (HP:0002986)1.92959291
56Dislocated radial head (HP:0003083)1.92419714
57Overriding aorta (HP:0002623)1.92345786
58Obsessive-compulsive behavior (HP:0000722)1.91831588
59Vertebral arch anomaly (HP:0008438)1.88959193
60Atrophic scars (HP:0001075)1.88492602
61Disproportionate tall stature (HP:0001519)1.87843604
62Increased connective tissue (HP:0009025)1.87776595
63Patellar dislocation (HP:0002999)1.87566230
64Abnormality of the radial head (HP:0003995)1.86589500
65Colitis (HP:0002583)1.86561142
66Premature rupture of membranes (HP:0001788)1.85988903
67Abnormality of the astrocytes (HP:0100707)1.85977393
68Astrocytoma (HP:0009592)1.85977393
69Cerebral inclusion bodies (HP:0100314)1.85218697
70Short nail (HP:0001799)1.85194328
71Gastrointestinal carcinoma (HP:0002672)1.84693701
72Malignant gastrointestinal tract tumors (HP:0006749)1.84693701
73Interstitial pulmonary disease (HP:0006530)1.83748412
74Skin tags (HP:0010609)1.82818764
75Broad thumb (HP:0011304)1.82771912
76Pseudobulbar signs (HP:0002200)1.82065854
77Hand muscle atrophy (HP:0009130)1.81563961
78Centrally nucleated skeletal muscle fibers (HP:0003687)1.80612385
79Turricephaly (HP:0000262)1.80340000
80Mitral regurgitation (HP:0001653)1.79156389
81Long palpebral fissure (HP:0000637)1.78947091
82Deviation of the thumb (HP:0009603)1.78523816
83Abnormality of the thoracic spine (HP:0100711)1.78450173
84Gastrointestinal inflammation (HP:0004386)1.78376527
85Selective tooth agenesis (HP:0001592)1.78362520
86Trigonocephaly (HP:0000243)1.78198371
87Abnormality of oral frenula (HP:0000190)1.77331104
88Striae distensae (HP:0001065)1.76900832
89Upper limb amyotrophy (HP:0009129)1.76808004
90Distal upper limb amyotrophy (HP:0007149)1.76808004
91Truncal obesity (HP:0001956)1.76510829
92Ankyloglossia (HP:0010296)1.75914040
93Aortic dissection (HP:0002647)1.75808115
94Hemorrhage of the eye (HP:0011885)1.75714967
95Osteolytic defects of the hand bones (HP:0009699)1.75189054
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.75189054
97Flat cornea (HP:0007720)1.75175033
98Prominent nose (HP:0000448)1.75027642
99Bowed forearm bones (HP:0003956)1.74343746
100Bowing of the arm (HP:0006488)1.74343746
101Milia (HP:0001056)1.73182960
102Arterial tortuosity (HP:0005116)1.72469832
103Fragile skin (HP:0001030)1.72288386
104Overgrowth (HP:0001548)1.71288905
105Exostoses (HP:0100777)1.70775141
106Metaphyseal cupping (HP:0003021)1.70691743
107Proximal placement of thumb (HP:0009623)1.70558923
108Sandal gap (HP:0001852)1.70494973
109Wormian bones (HP:0002645)1.70182845
110Pointed chin (HP:0000307)1.69278443
111Blue sclerae (HP:0000592)1.69126286
112Basal cell carcinoma (HP:0002671)1.68892445
113Joint laxity (HP:0001388)1.68891024
114Ureteral obstruction (HP:0006000)1.68748858
115Laryngomalacia (HP:0001601)1.68356225
116Increased variability in muscle fiber diameter (HP:0003557)1.67996854
117Visceral angiomatosis (HP:0100761)1.67907930
118Difficulty running (HP:0009046)1.67375215
119Abnormality of the phalanges of the hallux (HP:0010057)1.66964214
120Ureteral stenosis (HP:0000071)1.66891521
121Abnormal ossification of hand bones (HP:0005921)1.66879966
122Flattened epiphyses (HP:0003071)1.66640232
123Fibrous tissue neoplasm (HP:0012316)1.66392161
124Long toe (HP:0010511)1.66309742
125Hallux valgus (HP:0001822)1.66197953
126Neoplasm of the heart (HP:0100544)1.65862706
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65861291
128Cutis marmorata (HP:0000965)1.65763375
129J-shaped sella turcica (HP:0002680)1.65014435
130Deviation of the hallux (HP:0010051)1.64087435
131Cellulitis (HP:0100658)1.63850936
132Onion bulb formation (HP:0003383)1.63736497
133Papilloma (HP:0012740)1.63441689
134Verrucae (HP:0200043)1.63441689
135Lower limb amyotrophy (HP:0007210)1.63171339
136Vascular tortuosity (HP:0004948)1.62803063
137Fibroma (HP:0010614)1.62685670
138Syringomyelia (HP:0003396)1.62114658
139Spinal cord lesions (HP:0100561)1.62114658
140Mildly elevated creatine phosphokinase (HP:0008180)1.60994911
141Spontaneous hematomas (HP:0007420)1.60365782
142Inflammation of the large intestine (HP:0002037)1.59960186
143Stridor (HP:0010307)1.59934364
144Recurrent viral infections (HP:0004429)1.59845064
145Neonatal short-limb short stature (HP:0008921)1.59778275
146Short phalanx of the thumb (HP:0009660)1.59437631
147Deformed sella turcica (HP:0002681)1.58885502
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58300537
149Genu recurvatum (HP:0002816)1.58244040
150Hypercortisolism (HP:0001578)1.57989394
151Thick eyebrow (HP:0000574)1.57543388
152Natal tooth (HP:0000695)1.57461100
153Viral hepatitis (HP:0006562)1.57441418
154Segmental peripheral demyelination/remyelination (HP:0003481)1.57415391
155Hemangiomatosis (HP:0007461)1.57379661
156Thrombocytosis (HP:0001894)1.57128283
157Biliary tract neoplasm (HP:0100574)1.56906393
158Low anterior hairline (HP:0000294)1.56891586
159Severe short stature (HP:0003510)1.56166769
160Smooth philtrum (HP:0000319)1.55887639
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55183020
162Aortic regurgitation (HP:0001659)1.53861410
163Neurofibrillary tangles (HP:0002185)1.53765442
164Tracheomalacia (HP:0002779)1.53085438
165Difficulty climbing stairs (HP:0003551)1.52491673
166Abnormality of the distal phalanges of the toes (HP:0010182)1.52321900
167Abnormal vertebral ossification (HP:0100569)1.52094256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.21027753
2TRIB33.90794569
3CDK123.43094634
4PKN23.37216893
5MAP3K103.33597769
6SMG12.68588735
7PRPF4B2.48776583
8TTN2.27533737
9PTK62.19627154
10RIPK12.13410910
11MAP4K12.09258099
12TNK21.99539418
13CAMK1D1.93654200
14SIK11.91950891
15PDGFRA1.89217310
16FGFR41.81899330
17STK101.78060531
18ERN11.75294151
19CAMK1G1.65786485
20FGFR31.63826362
21EPHA21.62338724
22FGFR21.56892803
23NEK21.55846912
24BRD41.51507474
25LRRK21.48522390
26ICK1.45789816
27TGFBR21.44877321
28RPS6KB21.40215587
29PASK1.30019827
30LATS11.29298126
31MAP3K131.26410519
32SCYL21.24878176
33CDK61.23756724
34* MTOR1.23220916
35FLT31.21201921
36CDC71.20116818
37SIK21.18606807
38TGFBR11.18178359
39CDK41.15900412
40JAK31.10215542
41MST1R1.07895374
42PAK41.06325122
43DMPK1.03278215
44ALK1.01755343
45PDGFRB1.01029815
46MAP3K71.00805864
47AKT31.00663529
48STK30.96786993
49TYK20.95468903
50CAMKK10.92783747
51EPHB10.91818323
52JAK10.90401879
53MAP2K30.89489313
54GRK60.88936617
55FRK0.88197562
56CDK90.86646835
57ITK0.85085330
58PAK20.84411216
59TYRO30.82390456
60PRKD30.81990918
61CSF1R0.81767969
62ZAP700.81633630
63DDR20.81611133
64HIPK20.80073790
65LATS20.79352663
66PDPK10.78255782
67BTK0.76786317
68STK380.76648032
69NTRK10.76607039
70PRKCH0.75211977
71IRAK30.74965445
72FER0.73891863
73RET0.73539046
74MAP3K80.73401299
75RIPK40.72797543
76FGFR10.71615702
77CHUK0.71034660
78MAP3K60.70638040
79STK40.69085434
80PTK20.68289156
81MAP3K10.67757088
82TAOK30.67405864
83SGK2230.65247868
84SGK4940.65247868
85MAP2K20.63699070
86KIT0.63620645
87HCK0.62700171
88KSR20.61490107
89BMX0.60306470
90JAK20.60117998
91SGK30.58945955
92NEK60.57393067
93MELK0.56445643
94ATR0.56417831
95WNK10.56113656
96RPS6KA40.56108648
97CDC42BPA0.54856942
98PIM10.54815358
99DYRK1B0.54085815
100MAPKAPK30.53322062
101MET0.53004027
102SGK20.51838995
103PRKD20.51608216
104MAPK110.51333927
105PDK10.50445379
106MAPK150.49496576
107MAPK100.49075032
108CHEK10.48638296
109MAPK120.48612316
110LMTK20.48413498
111TAOK10.48056762
112TESK10.47694433
113TRPM70.46532370
114MAPK70.45271975
115MARK20.45169882
116EPHA30.45085206
117RPS6KA20.44326068
118CSK0.44316923
119PRKD10.43537013
120CDK70.42592938
121MAP3K30.42268273
122MAPK80.42223233
123MARK30.41533608
124PRKAA10.41362406
125PRKAA20.40902816
126RPS6KA10.40590425
127LCK0.40588587
128RPS6KL10.39823884
129RPS6KC10.39823884
130* CDK20.39021861
131ATM0.38338969
132ERBB20.37995911
133TTK0.36934631
134IRAK20.36772480
135RPS6KA60.36126033
136MAPK10.34363767
137TBK10.34321337
138MAP3K20.34286101

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.21067144
2Chronic myeloid leukemia_Homo sapiens_hsa052202.12766108
3Notch signaling pathway_Homo sapiens_hsa043301.78331173
4Small cell lung cancer_Homo sapiens_hsa052221.71927586
5mTOR signaling pathway_Homo sapiens_hsa041501.68094461
6Other glycan degradation_Homo sapiens_hsa005111.61122357
7B cell receptor signaling pathway_Homo sapiens_hsa046621.56528090
8Insulin resistance_Homo sapiens_hsa049311.55751017
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53485884
10Adherens junction_Homo sapiens_hsa045201.53231731
11MicroRNAs in cancer_Homo sapiens_hsa052061.45064484
12Proteoglycans in cancer_Homo sapiens_hsa052051.44806487
13Acute myeloid leukemia_Homo sapiens_hsa052211.44147923
14Non-small cell lung cancer_Homo sapiens_hsa052231.42285120
15Pancreatic cancer_Homo sapiens_hsa052121.40735747
16Focal adhesion_Homo sapiens_hsa045101.39456588
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37704480
18Endometrial cancer_Homo sapiens_hsa052131.36887159
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34728197
20Fatty acid biosynthesis_Homo sapiens_hsa000611.34556993
21Colorectal cancer_Homo sapiens_hsa052101.33516041
22ErbB signaling pathway_Homo sapiens_hsa040121.32241909
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.29705365
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28053793
25Antigen processing and presentation_Homo sapiens_hsa046121.27908475
26Primary immunodeficiency_Homo sapiens_hsa053401.27161474
27Choline metabolism in cancer_Homo sapiens_hsa052311.26583066
28Toxoplasmosis_Homo sapiens_hsa051451.25024019
29HTLV-I infection_Homo sapiens_hsa051661.23873053
30Viral myocarditis_Homo sapiens_hsa054161.23465203
31GnRH signaling pathway_Homo sapiens_hsa049121.22967052
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.21822774
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21606065
34Type II diabetes mellitus_Homo sapiens_hsa049301.19411470
35Viral carcinogenesis_Homo sapiens_hsa052031.18560997
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17943686
37Platelet activation_Homo sapiens_hsa046111.15066537
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.15055934
39Basal cell carcinoma_Homo sapiens_hsa052171.14928494
40Osteoclast differentiation_Homo sapiens_hsa043801.14769445
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12211059
42T cell receptor signaling pathway_Homo sapiens_hsa046601.11555954
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07515723
44Long-term potentiation_Homo sapiens_hsa047201.07024907
45mRNA surveillance pathway_Homo sapiens_hsa030151.06188678
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05332644
47Prostate cancer_Homo sapiens_hsa052151.03204539
48Glioma_Homo sapiens_hsa052141.00927870
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00808028
50Hepatitis B_Homo sapiens_hsa051610.99269707
51Cell cycle_Homo sapiens_hsa041100.99260662
52ECM-receptor interaction_Homo sapiens_hsa045120.98946894
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98274247
54Insulin signaling pathway_Homo sapiens_hsa049100.97351051
55Dorso-ventral axis formation_Homo sapiens_hsa043200.97030750
56AMPK signaling pathway_Homo sapiens_hsa041520.96952418
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96802530
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96160958
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95003966
60Prolactin signaling pathway_Homo sapiens_hsa049170.93165242
61Thyroid cancer_Homo sapiens_hsa052160.92767531
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92144306
63Pathways in cancer_Homo sapiens_hsa052000.91963841
64VEGF signaling pathway_Homo sapiens_hsa043700.91904614
65Hippo signaling pathway_Homo sapiens_hsa043900.90615432
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.90084812
67Hepatitis C_Homo sapiens_hsa051600.88836936
68Apoptosis_Homo sapiens_hsa042100.88295950
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88278209
70FoxO signaling pathway_Homo sapiens_hsa040680.88237220
71Bladder cancer_Homo sapiens_hsa052190.87434445
72Melanogenesis_Homo sapiens_hsa049160.87088830
73Herpes simplex infection_Homo sapiens_hsa051680.86604897
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86449546
75Measles_Homo sapiens_hsa051620.85453956
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.85304782
77Estrogen signaling pathway_Homo sapiens_hsa049150.84668395
78Prion diseases_Homo sapiens_hsa050200.84300288
79Renal cell carcinoma_Homo sapiens_hsa052110.84197713
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.82329861
81Leishmaniasis_Homo sapiens_hsa051400.80945450
82Amoebiasis_Homo sapiens_hsa051460.80767326
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80621890
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80466108
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79370474
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.78379964
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.75833050
88HIF-1 signaling pathway_Homo sapiens_hsa040660.74953613
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73642770
90Inositol phosphate metabolism_Homo sapiens_hsa005620.73117798
91Influenza A_Homo sapiens_hsa051640.73049367
92Cholinergic synapse_Homo sapiens_hsa047250.71871784
93Glucagon signaling pathway_Homo sapiens_hsa049220.71314905
94Gap junction_Homo sapiens_hsa045400.70808964
95Axon guidance_Homo sapiens_hsa043600.70555475
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70264998
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.68394840
98Rap1 signaling pathway_Homo sapiens_hsa040150.68202749
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67866177
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.67785346
101Gastric acid secretion_Homo sapiens_hsa049710.67236267
102Dilated cardiomyopathy_Homo sapiens_hsa054140.66150296
103Thyroid hormone synthesis_Homo sapiens_hsa049180.65816081
104Selenocompound metabolism_Homo sapiens_hsa004500.65743987
105One carbon pool by folate_Homo sapiens_hsa006700.63909031
106Renin secretion_Homo sapiens_hsa049240.63762933
107Chemokine signaling pathway_Homo sapiens_hsa040620.63239841
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63119291
109Spliceosome_Homo sapiens_hsa030400.62947804
110MAPK signaling pathway_Homo sapiens_hsa040100.62785881
111TNF signaling pathway_Homo sapiens_hsa046680.61927821
112Oxytocin signaling pathway_Homo sapiens_hsa049210.61871515
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.61505602
114Hedgehog signaling pathway_Homo sapiens_hsa043400.60611467
115TGF-beta signaling pathway_Homo sapiens_hsa043500.60605561
116Protein digestion and absorption_Homo sapiens_hsa049740.60299825
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59403970
118Fructose and mannose metabolism_Homo sapiens_hsa000510.58326034
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57679046
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56939253
121Systemic lupus erythematosus_Homo sapiens_hsa053220.56076390
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54814929
123Tight junction_Homo sapiens_hsa045300.54615983
124ABC transporters_Homo sapiens_hsa020100.54412692
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.54155478
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52938192
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52846581
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52805867
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52352369
130RNA transport_Homo sapiens_hsa030130.52196993
131Endocytosis_Homo sapiens_hsa041440.51965424

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