NUGGC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* somatic diversification of immune receptors via somatic mutation (GO:0002566)8.60372860
2* somatic hypermutation of immunoglobulin genes (GO:0016446)8.60372860
3negative regulation of gene silencing (GO:0060969)7.08499369
4regulation of B cell receptor signaling pathway (GO:0050855)5.74723142
5regulation of germinal center formation (GO:0002634)5.67994130
6B cell receptor signaling pathway (GO:0050853)5.65415724
7behavioral response to nicotine (GO:0035095)5.33342555
8cellular response to zinc ion (GO:0071294)5.29288268
9regulation of chromatin silencing (GO:0031935)5.29031497
10complement activation, classical pathway (GO:0006958)5.26817945
11acrosome assembly (GO:0001675)5.22273934
12DNA demethylation (GO:0080111)5.16963669
13sperm-egg recognition (GO:0035036)5.13118193
14antigen processing and presentation of endogenous antigen (GO:0019883)5.03460484
15multicellular organism reproduction (GO:0032504)5.03457070
16sperm motility (GO:0030317)4.93497266
17cell-cell recognition (GO:0009988)4.68415200
18somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.68247024
19isotype switching (GO:0045190)4.68247024
20somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.68247024
21pyrimidine nucleoside catabolic process (GO:0046135)4.60212524
22indole-containing compound catabolic process (GO:0042436)4.59195379
23indolalkylamine catabolic process (GO:0046218)4.59195379
24tryptophan catabolic process (GO:0006569)4.59195379
25fusion of sperm to egg plasma membrane (GO:0007342)4.58063831
26cell wall macromolecule metabolic process (GO:0044036)4.49983360
27cell wall macromolecule catabolic process (GO:0016998)4.49983360
28L-fucose catabolic process (GO:0042355)4.47841499
29fucose catabolic process (GO:0019317)4.47841499
30L-fucose metabolic process (GO:0042354)4.47841499
31positive regulation of gene expression, epigenetic (GO:0045815)4.38450858
32spermatid nucleus differentiation (GO:0007289)4.35857105
33DNA deamination (GO:0045006)4.29832590
34negative regulation of B cell apoptotic process (GO:0002903)4.28938058
35indolalkylamine metabolic process (GO:0006586)4.24949398
36kynurenine metabolic process (GO:0070189)4.24877132
37binding of sperm to zona pellucida (GO:0007339)4.19332262
38reproduction (GO:0000003)4.16539399
39tryptophan metabolic process (GO:0006568)4.14411064
40B cell activation involved in immune response (GO:0002312)4.08913282
41complement activation (GO:0006956)4.05015988
42DNA dealkylation (GO:0035510)4.04305790
43telomere maintenance via semi-conservative replication (GO:0032201)3.98541009
44cellular ketone body metabolic process (GO:0046950)3.90411140
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.89452145
46response to pheromone (GO:0019236)3.85766437
47somatic recombination of immunoglobulin gene segments (GO:0016447)3.82593486
48germinal center formation (GO:0002467)3.74807643
49DNA strand elongation involved in DNA replication (GO:0006271)3.72215643
50acrosome reaction (GO:0007340)3.71554792
51cilium or flagellum-dependent cell motility (GO:0001539)3.67546825
52regulation of B cell apoptotic process (GO:0002902)3.66828114
53* somatic diversification of immunoglobulins (GO:0016445)3.64790098
54B cell proliferation (GO:0042100)3.61871583
55water-soluble vitamin biosynthetic process (GO:0042364)3.60899800
56negative regulation of telomere maintenance (GO:0032205)3.60528217
57exogenous drug catabolic process (GO:0042738)3.59904341
58spermatid development (GO:0007286)3.51944561
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51062664
60positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.50842894
61telomere maintenance via recombination (GO:0000722)3.50428645
62ketone body metabolic process (GO:1902224)3.49890616
63drug catabolic process (GO:0042737)3.48292148
64DNA strand elongation (GO:0022616)3.45524217
65proline biosynthetic process (GO:0006561)3.33178369
66regulation of B cell proliferation (GO:0030888)3.29773556
67regulation of B cell differentiation (GO:0045577)3.27445838
68plasma membrane fusion (GO:0045026)3.25934333
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21700564
70mitotic recombination (GO:0006312)3.21336483
71natural killer cell mediated immunity (GO:0002228)3.21207585
72natural killer cell mediated cytotoxicity (GO:0042267)3.21207585
73sulfation (GO:0051923)3.20711571
74base-excision repair (GO:0006284)3.19275124
75amine catabolic process (GO:0009310)3.18370869
76cellular biogenic amine catabolic process (GO:0042402)3.18370869
77detection of light stimulus involved in sensory perception (GO:0050962)3.15541435
78detection of light stimulus involved in visual perception (GO:0050908)3.15541435
79S-adenosylmethionine metabolic process (GO:0046500)3.13733671
80indole-containing compound metabolic process (GO:0042430)3.11170717
81positive thymic T cell selection (GO:0045059)3.08531880
82neural tube formation (GO:0001841)3.08006300
83regulation of gene silencing (GO:0060968)3.05831604
84single fertilization (GO:0007338)3.05342266
85piRNA metabolic process (GO:0034587)3.05199377
86negative regulation of mast cell activation (GO:0033004)3.05175012
87chromosome condensation (GO:0030261)3.04682079
88negative regulation of chromatin modification (GO:1903309)3.03922112
89positive regulation of protein homooligomerization (GO:0032464)3.03440120
90axonemal dynein complex assembly (GO:0070286)3.03381174
91oxidative demethylation (GO:0070989)3.03234611
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03219201
93mitotic sister chromatid segregation (GO:0000070)3.01872386
94translesion synthesis (GO:0019985)3.00311906
95aromatic amino acid family catabolic process (GO:0009074)2.98771076
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98387410
97epithelial cilium movement (GO:0003351)2.96887011
98negative regulation of inclusion body assembly (GO:0090084)2.95789342
99pyrimidine ribonucleoside metabolic process (GO:0046131)2.94576049
100motile cilium assembly (GO:0044458)2.93080170
101preassembly of GPI anchor in ER membrane (GO:0016254)2.92378381
102humoral immune response (GO:0006959)2.92091907
103rRNA catabolic process (GO:0016075)2.91389094
104single strand break repair (GO:0000012)2.91080845
105synaptonemal complex organization (GO:0070193)2.88695731
106microtubule depolymerization (GO:0007019)2.88519882
107male meiosis (GO:0007140)2.85886685
108regulation of hexokinase activity (GO:1903299)2.84268856
109regulation of glucokinase activity (GO:0033131)2.84268856
110platelet dense granule organization (GO:0060155)2.83410945
111sister chromatid segregation (GO:0000819)2.82950941
112B cell activation (GO:0042113)2.81878280
113somatic cell DNA recombination (GO:0016444)2.81651519
114somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.81651519
115dopamine transport (GO:0015872)2.81506835
116telomere maintenance via telomere lengthening (GO:0010833)2.80518862
117DNA packaging (GO:0006323)2.80027608
118positive regulation of B cell proliferation (GO:0030890)2.80017531
119synaptonemal complex assembly (GO:0007130)2.77649629
120neuronal action potential (GO:0019228)2.77454861
121RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77262718
122axoneme assembly (GO:0035082)2.76935949
123negative regulation of B cell mediated immunity (GO:0002713)2.75075041
124negative regulation of immunoglobulin mediated immune response (GO:0002890)2.75075041
125gamma-aminobutyric acid transport (GO:0015812)2.74953441
126* somatic diversification of immune receptors (GO:0002200)2.74895942
127regulation of cilium movement (GO:0003352)2.74888116
128immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.71761023
129Fc-gamma receptor signaling pathway (GO:0038094)2.71761023
130Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.71761023
131nuclear pore complex assembly (GO:0051292)2.71115639
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.70947519
133NADH dehydrogenase complex assembly (GO:0010257)2.70947519
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70947519
135protein complex biogenesis (GO:0070271)2.70779290
136B cell homeostasis (GO:0001782)2.70384698
137positive regulation of fatty acid transport (GO:2000193)2.69936637
138mitotic sister chromatid cohesion (GO:0007064)2.69849768
139mature B cell differentiation (GO:0002335)2.69004316
140behavioral response to ethanol (GO:0048149)2.68786607
141postreplication repair (GO:0006301)2.68614356
142replication fork processing (GO:0031297)2.66993015
143DNA replication-dependent nucleosome organization (GO:0034723)2.66766263
144DNA replication-dependent nucleosome assembly (GO:0006335)2.66766263
145cellular response to ATP (GO:0071318)2.66596245
146regulation of action potential (GO:0098900)2.64847188
147respiratory chain complex IV assembly (GO:0008535)2.64288290
148recombinational repair (GO:0000725)2.64002983
149double-strand break repair via homologous recombination (GO:0000724)2.63195683
150benzene-containing compound metabolic process (GO:0042537)2.62969857
151DNA methylation involved in gamete generation (GO:0043046)2.61398067
152protein K11-linked deubiquitination (GO:0035871)2.61091661
153protein polyglutamylation (GO:0018095)2.59051170
154reflex (GO:0060004)2.58664512
155regulation of memory T cell differentiation (GO:0043380)2.54927222
156mitochondrial respiratory chain complex assembly (GO:0033108)2.53754887
157regulation of telomere maintenance (GO:0032204)2.53135002
158primary amino compound metabolic process (GO:1901160)2.51209914
159negative regulation of DNA-dependent DNA replication (GO:2000104)2.50976005
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50910294
161regulation of nuclear cell cycle DNA replication (GO:0033262)2.50368317
162snRNA transcription (GO:0009301)2.49616466
163cytochrome complex assembly (GO:0017004)2.49111452
164L-methionine salvage (GO:0071267)2.47937008
165L-methionine biosynthetic process (GO:0071265)2.47937008
166amino acid salvage (GO:0043102)2.47937008
167negative regulation of reactive oxygen species metabolic process (GO:2000378)2.46487142
168protein import into peroxisome matrix (GO:0016558)2.45901568
169aromatic amino acid family metabolic process (GO:0009072)2.45195041
170mannosylation (GO:0097502)2.43800798
171reciprocal meiotic recombination (GO:0007131)2.41253174
172reciprocal DNA recombination (GO:0035825)2.41253174
173phosphatidylinositol acyl-chain remodeling (GO:0036149)2.41008499
174synaptic transmission, cholinergic (GO:0007271)2.40217465
175regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.39775218
176protein-cofactor linkage (GO:0018065)2.39020990
177protein K6-linked ubiquitination (GO:0085020)2.38354734
178regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37329283
179DNA double-strand break processing (GO:0000729)2.37168089
180photoreceptor cell maintenance (GO:0045494)2.37132458
181thyroid hormone metabolic process (GO:0042403)2.36866301
182purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.36616028
1833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.36616028
184alkaloid metabolic process (GO:0009820)2.36218894
185positive regulation of defense response to virus by host (GO:0002230)2.35133785
186negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34585247
187L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.34369990
188rhodopsin mediated signaling pathway (GO:0016056)2.33404241
189signal peptide processing (GO:0006465)2.33350405
190cytidine catabolic process (GO:0006216)16.8048037
191cytidine deamination (GO:0009972)16.8048037
192cytidine metabolic process (GO:0046087)16.8048037
193pyrimidine ribonucleoside catabolic process (GO:0046133)13.0369902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.32773432
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.99053043
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.83453417
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.13929975
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.81961945
6ZNF274_21170338_ChIP-Seq_K562_Hela3.76425162
7MYC_22102868_ChIP-Seq_BL_Human3.65770893
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60262528
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.43609416
10VDR_22108803_ChIP-Seq_LS180_Human3.10370408
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07544248
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.83551512
13IGF1R_20145208_ChIP-Seq_DFB_Human2.83336957
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72505033
15GBX2_23144817_ChIP-Seq_PC3_Human2.67926136
16EZH2_22144423_ChIP-Seq_EOC_Human2.52076379
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47558795
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46420109
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.39265177
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37594908
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35149705
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34116897
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23894544
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13150454
25FUS_26573619_Chip-Seq_HEK293_Human2.11995504
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09774975
27ER_23166858_ChIP-Seq_MCF-7_Human2.06107750
28TAF15_26573619_Chip-Seq_HEK293_Human2.04809819
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03132921
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01097557
31EWS_26573619_Chip-Seq_HEK293_Human1.99626563
32IRF1_19129219_ChIP-ChIP_H3396_Human1.92147467
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91116624
34P300_19829295_ChIP-Seq_ESCs_Human1.86955260
35MYB_26560356_Chip-Seq_TH1_Human1.81911892
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.80950449
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74924617
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72460565
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.70330840
40BCAT_22108803_ChIP-Seq_LS180_Human1.69310192
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65376887
42AR_21909140_ChIP-Seq_LNCAP_Human1.64224811
43MYB_26560356_Chip-Seq_TH2_Human1.62068812
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60608781
45TP53_22573176_ChIP-Seq_HFKS_Human1.56113576
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55238805
47STAT3_23295773_ChIP-Seq_U87_Human1.54880891
48CBP_20019798_ChIP-Seq_JUKART_Human1.53841307
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53841307
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49760479
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48051744
52MAF_26560356_Chip-Seq_TH1_Human1.46549313
53FOXP3_21729870_ChIP-Seq_TREG_Human1.43328784
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43271337
55TCF4_23295773_ChIP-Seq_U87_Human1.41575848
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38236253
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37645399
58FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37639368
59AR_25329375_ChIP-Seq_VCAP_Human1.37403885
60SOX2_19829295_ChIP-Seq_ESCs_Human1.35779279
61NANOG_19829295_ChIP-Seq_ESCs_Human1.35779279
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.35196702
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35196702
64VDR_21846776_ChIP-Seq_THP-1_Human1.35137328
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.34336730
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.34321001
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33148998
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33057656
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32790882
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32374250
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32093236
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31789189
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31504456
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31503296
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31503296
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31443123
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31234724
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.30620483
79SMAD4_21799915_ChIP-Seq_A2780_Human1.28222843
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27131168
81MYC_18940864_ChIP-ChIP_HL60_Human1.25747975
82TCF4_22108803_ChIP-Seq_LS180_Human1.25169614
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.24366830
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.24328369
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24327188
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.24038573
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.23470724
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21822938
89KDM5A_27292631_Chip-Seq_BREAST_Human1.21498647
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21384713
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21180012
92REST_21632747_ChIP-Seq_MESCs_Mouse1.20870372
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20453006
94AR_20517297_ChIP-Seq_VCAP_Human1.19957968
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19761798
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19128417
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18683560
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18288761
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17700865
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17415805
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17390218
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.17296492
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.16565886
104NCOR_22424771_ChIP-Seq_293T_Human1.16025846
105MAF_26560356_Chip-Seq_TH2_Human1.15897645
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.15550639
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.13706662
108RUNX2_22187159_ChIP-Seq_PCA_Human1.13218460
109VDR_24763502_ChIP-Seq_THP-1_Human1.12827380
110SPI1_23547873_ChIP-Seq_NB4_Human1.12755738
111MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12078785
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11672120
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11137894
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11109709
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11044600
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.10576327
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09879946
118GATA3_26560356_Chip-Seq_TH1_Human1.08971969
119UTX_26944678_Chip-Seq_JUKART_Human1.08957990
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.07204098
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.06960867
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06341670
123HOXB7_26014856_ChIP-Seq_BT474_Human1.06096592
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.05705826
125NOTCH1_21737748_ChIP-Seq_TLL_Human1.05230256
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.05051856
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04444571
128CDX2_22108803_ChIP-Seq_LS180_Human1.04322145
129MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04253097
130GATA3_27048872_Chip-Seq_THYMUS_Human1.02854620
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02499381
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02288024
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02057333
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01994151
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01189873
136P53_22387025_ChIP-Seq_ESCs_Mouse1.00996432
137GATA3_26560356_Chip-Seq_TH2_Human1.00653101
138ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00639991
139AR_21572438_ChIP-Seq_LNCaP_Human1.00454220
140FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00119951
141NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00014953
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99964502
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.99761417
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.99646946
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99330532
146PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97242692
147FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96893528
148ELK1_19687146_ChIP-ChIP_HELA_Human0.96867329
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96622988
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96327843
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96179607
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95985862
153P300_27268052_Chip-Seq_Bcells_Human0.95290002
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94885169
155VDR_23849224_ChIP-Seq_CD4+_Human0.94874447
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93898224
157CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92589817
158MYC_18555785_ChIP-Seq_MESCs_Mouse0.91825887
159RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91678861
160PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90654479
161PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90447596
162RUNX_20019798_ChIP-Seq_JUKART_Human0.89538633
163CIITA_25753668_ChIP-Seq_RAJI_Human0.89534632
164NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88956897
165IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87734262
166MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87367404
167SPI1_26923725_Chip-Seq_HPCs_Mouse0.87071109
168PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87050578
169ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87040473
170MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86952089
171NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86604231
172NFE2_27457419_Chip-Seq_LIVER_Mouse0.86177278
173BCL6_27268052_Chip-Seq_Bcells_Human0.85982562
174PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85743336
175STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85248987
176TET1_21451524_ChIP-Seq_MESCs_Mouse0.85069817
177CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83370218
178MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82906860
179ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81832899
180MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81590361
181RUNX1_22412390_ChIP-Seq_EML_Mouse0.81460466
182P53_21459846_ChIP-Seq_SAOS-2_Human0.80998616
183CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80581648
184JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80305820
185TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79128751
186CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79060375
187TCF7_22412390_ChIP-Seq_EML_Mouse0.78703200
188GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77602007
189KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76458848
190DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76114897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.82751170
2MP0001835_abnormal_antigen_presentation4.77876433
3MP0001800_abnormal_humoral_immune4.58552142
4MP0010094_abnormal_chromosome_stability4.06570956
5MP0008057_abnormal_DNA_replication3.91680083
6MP0001790_abnormal_immune_system3.72247621
7MP0005387_immune_system_phenotype3.72247621
8MP0000685_abnormal_immune_system3.32181640
9MP0002452_abnormal_antigen_presenting3.16852163
10MP0000013_abnormal_adipose_tissue2.92871238
11MP0000569_abnormal_digit_pigmentation2.83725960
12MP0001986_abnormal_taste_sensitivity2.67985787
13MP0002723_abnormal_immune_serum2.58777340
14MP0005671_abnormal_response_to2.57660892
15MP0002933_joint_inflammation2.56307774
16MP0008877_abnormal_DNA_methylation2.49551077
17MP0003303_peritoneal_inflammation2.42139271
18MP0002398_abnormal_bone_marrow2.40658115
19MP0002420_abnormal_adaptive_immunity2.39168257
20MP0003693_abnormal_embryo_hatching2.36644132
21MP0000689_abnormal_spleen_morphology2.35256649
22MP0001929_abnormal_gametogenesis2.34315839
23MP0002138_abnormal_hepatobiliary_system2.32735331
24MP0001819_abnormal_immune_cell2.28651589
25MP0001968_abnormal_touch/_nociception2.25957009
26MP0005551_abnormal_eye_electrophysiolog2.25186194
27MP0005000_abnormal_immune_tolerance2.20846276
28MP0000716_abnormal_immune_system2.10204404
29MP0003698_abnormal_male_reproductive2.09929296
30MP0006072_abnormal_retinal_apoptosis1.97047316
31MP0008872_abnormal_physiological_respon1.96242422
32MP0003111_abnormal_nucleus_morphology1.94581439
33MP0002102_abnormal_ear_morphology1.92363910
34MP0008058_abnormal_DNA_repair1.91204931
35MP0003646_muscle_fatigue1.87834732
36MP0003077_abnormal_cell_cycle1.87319019
37MP0003763_abnormal_thymus_physiology1.83894154
38MP0002722_abnormal_immune_system1.80056665
39MP0005645_abnormal_hypothalamus_physiol1.78904767
40MP0004957_abnormal_blastocyst_morpholog1.78471991
41MP0002837_dystrophic_cardiac_calcinosis1.77913286
42MP0006292_abnormal_olfactory_placode1.77814886
43MP0002638_abnormal_pupillary_reflex1.77398339
44MP0002429_abnormal_blood_cell1.75458556
45MP0004142_abnormal_muscle_tone1.75114496
46MP0005253_abnormal_eye_physiology1.73589317
47MP0000427_abnormal_hair_cycle1.71857105
48MP0008995_early_reproductive_senescence1.70557722
49MP0004043_abnormal_pH_regulation1.66288641
50MP0009046_muscle_twitch1.66245134
51MP0005646_abnormal_pituitary_gland1.63030368
52MP0009745_abnormal_behavioral_response1.61615143
53MP0002736_abnormal_nociception_after1.61088358
54MP0000372_irregular_coat_pigmentation1.60186082
55MP0002163_abnormal_gland_morphology1.59053360
56MP0004885_abnormal_endolymph1.58595847
57MP0002148_abnormal_hypersensitivity_rea1.58549932
58MP0002139_abnormal_hepatobiliary_system1.58456550
59MP0002210_abnormal_sex_determination1.55213136
60MP0005084_abnormal_gallbladder_morpholo1.55051799
61MP0001501_abnormal_sleep_pattern1.47050688
62MP0003011_delayed_dark_adaptation1.46897928
63MP0002019_abnormal_tumor_incidence1.45727307
64MP0003136_yellow_coat_color1.45016695
65MP0002272_abnormal_nervous_system1.42447579
66MP0001485_abnormal_pinna_reflex1.39735621
67MP0005174_abnormal_tail_pigmentation1.39425808
68MP0001145_abnormal_male_reproductive1.37487075
69MP0001853_heart_inflammation1.36818831
70MP0000003_abnormal_adipose_tissue1.33809453
71MP0010386_abnormal_urinary_bladder1.31933500
72MP0004742_abnormal_vestibular_system1.30529139
73MP0005025_abnormal_response_to1.30423989
74MP0002928_abnormal_bile_duct1.28405988
75MP0002161_abnormal_fertility/fecundity1.26348006
76MP0000631_abnormal_neuroendocrine_gland1.22946402
77MP0005360_urolithiasis1.22887397
78MP0003195_calcinosis1.18688305
79MP0005332_abnormal_amino_acid1.13395617
80MP0000653_abnormal_sex_gland1.12717545
81MP0001845_abnormal_inflammatory_respons1.11721848
82MP0010352_gastrointestinal_tract_polyps1.11376870
83MP0002405_respiratory_system_inflammati1.08533426
84MP0001730_embryonic_growth_arrest1.08093250
85MP0005379_endocrine/exocrine_gland_phen1.07170173
86MP0002735_abnormal_chemical_nociception1.06699237
87MP0010329_abnormal_lipoprotein_level1.05814723
88MP0006276_abnormal_autonomic_nervous1.05745051
89MP0005075_abnormal_melanosome_morpholog1.04889962
90MP0004134_abnormal_chest_morphology1.04865664
91MP0002064_seizures1.04448391
92MP0009697_abnormal_copulation1.04398415
93MP0004145_abnormal_muscle_electrophysio1.02671272
94MP0004133_heterotaxia1.02609976
95MP0002277_abnormal_respiratory_mucosa1.02286757
96MP0000703_abnormal_thymus_morphology1.02023624
97MP0001486_abnormal_startle_reflex0.99694882
98MP0001984_abnormal_olfaction0.99158434
99MP0002938_white_spotting0.98877129
100MP0005310_abnormal_salivary_gland0.98407411
101MP0001666_abnormal_nutrient_absorption0.97903856
102MP0002876_abnormal_thyroid_physiology0.97661806
103MP0002095_abnormal_skin_pigmentation0.97543967
104MP0002693_abnormal_pancreas_physiology0.96722127
105MP0004924_abnormal_behavior0.96123294
106MP0005386_behavior/neurological_phenoty0.96123294
107MP0001191_abnormal_skin_condition0.95058643
108MP0002136_abnormal_kidney_physiology0.94771134
109MP0002733_abnormal_thermal_nociception0.94635175
110MP0002572_abnormal_emotion/affect_behav0.93676268
111MP0001764_abnormal_homeostasis0.92687460
112MP0000383_abnormal_hair_follicle0.92416836
113MP0008875_abnormal_xenobiotic_pharmacok0.92392957
114MP0002419_abnormal_innate_immunity0.90675531
115MP0003436_decreased_susceptibility_to0.90065761
116MP0002067_abnormal_sensory_capabilities0.89904924
117MP0002557_abnormal_social/conspecific_i0.89874682
118MP0003252_abnormal_bile_duct0.89621268
119MP0001970_abnormal_pain_threshold0.89536486
120MP0004510_myositis0.88075159
121MP0003718_maternal_effect0.87983858
122MP0004808_abnormal_hematopoietic_stem0.86158083
123MP0009764_decreased_sensitivity_to0.85800945
124MP0001529_abnormal_vocalization0.84869585
125MP0003300_gastrointestinal_ulcer0.83243468
126MP0001905_abnormal_dopamine_level0.83004471
127MP0004147_increased_porphyrin_level0.82104106
128MP0005195_abnormal_posterior_eye0.81485348
129MP0005423_abnormal_somatic_nervous0.80976194
130MP0000350_abnormal_cell_proliferation0.80508879
131MP0003880_abnormal_central_pattern0.80160177
132MP0000313_abnormal_cell_death0.78488023
133MP0005085_abnormal_gallbladder_physiolo0.78029785
134MP0003121_genomic_imprinting0.77098372
135MP0001502_abnormal_circadian_rhythm0.76427105
136MP0005266_abnormal_metabolism0.74724903
137MP0002282_abnormal_trachea_morphology0.73971588
138MP0000015_abnormal_ear_pigmentation0.73688245
139MP0005167_abnormal_blood-brain_barrier0.73415761
140MP0000609_abnormal_liver_physiology0.71976425
141MP0002166_altered_tumor_susceptibility0.71345290
142MP0001348_abnormal_lacrimal_gland0.71024989
143MP0009785_altered_susceptibility_to0.69351488
144MP0010307_abnormal_tumor_latency0.69061545
145MP0004947_skin_inflammation0.66953217
146MP0005076_abnormal_cell_differentiation0.66723075
147MP0002160_abnormal_reproductive_system0.65012252
148MP0005584_abnormal_enzyme/coenzyme_acti0.64834303
149MP0010234_abnormal_vibrissa_follicle0.64324685
150MP0006036_abnormal_mitochondrial_physio0.64143150
151MP0003656_abnormal_erythrocyte_physiolo0.62386912
152MP0003806_abnormal_nucleotide_metabolis0.61495912
153MP0002083_premature_death0.60671614
154MP0003786_premature_aging0.58823816
155MP0005451_abnormal_body_composition0.56606975
156MP0008932_abnormal_embryonic_tissue0.56058363
157MP0005365_abnormal_bile_salt0.55850823
158MP0002396_abnormal_hematopoietic_system0.55699050
159MP0003787_abnormal_imprinting0.55669764
160MP0002909_abnormal_adrenal_gland0.55116637
161MP0000598_abnormal_liver_morphology0.54785015
162MP0008469_abnormal_protein_level0.52680463
163MP0003705_abnormal_hypodermis_morpholog0.51571341
164MP0002653_abnormal_ependyma_morphology0.50906842
165MP0001919_abnormal_reproductive_system0.50600572
166MP0005389_reproductive_system_phenotype0.50416280
167MP0001697_abnormal_embryo_size0.50397165
168MP0005397_hematopoietic_system_phenotyp0.50132531
169MP0001545_abnormal_hematopoietic_system0.50132531
170MP0005464_abnormal_platelet_physiology0.49326103
171MP0009643_abnormal_urine_homeostasis0.48725700

Predicted human phenotypes

RankGene SetZ-score
1Recurrent sinusitis (HP:0011108)8.09988906
2Agammaglobulinemia (HP:0004432)7.91166501
3Gastrointestinal stroma tumor (HP:0100723)7.71845170
4Recurrent bronchitis (HP:0002837)6.70525862
5Recurrent lower respiratory tract infections (HP:0002783)5.86000835
6IgA deficiency (HP:0002720)5.84947154
7Small epiphyses (HP:0010585)5.62329095
8Chronic sinusitis (HP:0011109)5.25720961
9Bronchitis (HP:0012387)4.97315883
10IgG deficiency (HP:0004315)4.93553284
11Recurrent pneumonia (HP:0006532)4.88714455
12Abnormality of cells of the lymphoid lineage (HP:0012140)4.72612725
13Cellulitis (HP:0100658)4.68800579
14Lymphopenia (HP:0001888)4.66882713
15Recurrent otitis media (HP:0000403)4.66140848
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.58318119
17Colitis (HP:0002583)4.27886839
18Pancreatic cysts (HP:0001737)4.24243721
19Emphysema (HP:0002097)4.21229483
20Verrucae (HP:0200043)4.14519059
21Papilloma (HP:0012740)4.14519059
22Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.11807020
23Absent epiphyses (HP:0010577)4.11807020
24Irregular epiphyses (HP:0010582)4.09102105
25Hypoplasia of the capital femoral epiphysis (HP:0003090)3.99238074
26Congenital stationary night blindness (HP:0007642)3.90787523
27Dynein arm defect of respiratory motile cilia (HP:0012255)3.84419837
28Absent/shortened dynein arms (HP:0200106)3.84419837
29Molar tooth sign on MRI (HP:0002419)3.83040440
30Abnormality of midbrain morphology (HP:0002418)3.83040440
31Autoimmune thrombocytopenia (HP:0001973)3.76108206
32Pancreatic fibrosis (HP:0100732)3.76016483
33Nasal polyposis (HP:0100582)3.75837188
34Epiphyseal dysplasia (HP:0002656)3.65742049
35Vasculitis (HP:0002633)3.61398610
36True hermaphroditism (HP:0010459)3.61003940
37Rhinitis (HP:0012384)3.60552747
38IgM deficiency (HP:0002850)3.49255754
39Flattened epiphyses (HP:0003071)3.48475374
40Nephronophthisis (HP:0000090)3.41516889
41Abnormality of the renal cortex (HP:0011035)3.37398976
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.37395352
43Inflammation of the large intestine (HP:0002037)3.26025399
44Meningitis (HP:0001287)3.16511813
45Gastrointestinal inflammation (HP:0004386)3.12517053
46Type II lissencephaly (HP:0007260)3.08900285
47Chronic hepatic failure (HP:0100626)3.08466156
48Irregular vertebral endplates (HP:0003301)3.03813600
49Restrictive lung disease (HP:0002091)3.02204951
50Abnormality of the renal medulla (HP:0100957)2.99683567
51Recurrent viral infections (HP:0004429)2.96952561
52Abnormal respiratory motile cilium physiology (HP:0012261)2.96107573
53B lymphocytopenia (HP:0010976)2.93283021
54Abnormality of B cell number (HP:0010975)2.93283021
55Abnormal respiratory epithelium morphology (HP:0012253)2.93247593
56Abnormal respiratory motile cilium morphology (HP:0005938)2.93247593
57Abnormal tarsal ossification (HP:0008369)2.91549164
58Abnormality of the nasal mucosa (HP:0000433)2.85514103
59Abnormality of alanine metabolism (HP:0010916)2.84106425
60Hyperalaninemia (HP:0003348)2.84106425
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.84106425
62Osteomyelitis (HP:0002754)2.82268655
63Leukopenia (HP:0001882)2.76925703
64Abolished electroretinogram (ERG) (HP:0000550)2.74497374
65Renal cortical cysts (HP:0000803)2.74337512
66Bronchiectasis (HP:0002110)2.70405540
67Medial flaring of the eyebrow (HP:0010747)2.70221117
68Attenuation of retinal blood vessels (HP:0007843)2.70117223
69Abnormality of the vertebral endplates (HP:0005106)2.69975357
70Hyperventilation (HP:0002883)2.68736998
71Pendular nystagmus (HP:0012043)2.67236996
72Abnormal foot bone ossification (HP:0010675)2.59396025
73Tubular atrophy (HP:0000092)2.54127882
74Inability to walk (HP:0002540)2.53121965
75Abnormality of T cell physiology (HP:0011840)2.52248032
76Congenital, generalized hypertrichosis (HP:0004540)2.52180662
77Cupped ribs (HP:0000887)2.52080995
78Gaze-evoked nystagmus (HP:0000640)2.51210690
79Cystic liver disease (HP:0006706)2.50970511
80Polydipsia (HP:0001959)2.46236905
81Abnormal drinking behavior (HP:0030082)2.46236905
82Progressive inability to walk (HP:0002505)2.45542959
83Short femoral neck (HP:0100864)2.44022930
84Progressive cerebellar ataxia (HP:0002073)2.40536003
85Thyroiditis (HP:0100646)2.40245190
86Stomach cancer (HP:0012126)2.40010109
87Abnormal rod and cone electroretinograms (HP:0008323)2.39567081
88Panhypogammaglobulinemia (HP:0003139)2.38447603
89Chronic bronchitis (HP:0004469)2.37500915
90Genetic anticipation (HP:0003743)2.36314366
91Fair hair (HP:0002286)2.35361999
92Carpal bone hypoplasia (HP:0001498)2.34513828
93Lymphoma (HP:0002665)2.34511398
94Chronic otitis media (HP:0000389)2.34036625
95Abnormal biliary tract physiology (HP:0012439)2.30657149
96Bile duct proliferation (HP:0001408)2.30657149
97Sepsis (HP:0100806)2.30494301
98Infertility (HP:0000789)2.28743151
99Sclerocornea (HP:0000647)2.27559431
100Aplasia/Hypoplasia of the uvula (HP:0010293)2.26446022
101Abnormal ciliary motility (HP:0012262)2.21630587
102Skin rash (HP:0000988)2.20907739
103Arthropathy (HP:0003040)2.20890901
104Hypothermia (HP:0002045)2.20279992
105Cerebellar dysplasia (HP:0007033)2.18466981
106Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.18423773
107Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.17439218
108Abnormality of femoral epiphyses (HP:0006499)2.17439218
109Protruding tongue (HP:0010808)2.16611122
110Abnormality of the renal collecting system (HP:0004742)2.15782325
111Large for gestational age (HP:0001520)2.15690351
112Abnormality of the epiphysis of the femoral head (HP:0010574)2.11318585
113Delayed epiphyseal ossification (HP:0002663)2.10688920
114Duplicated collecting system (HP:0000081)2.10364980
115Furrowed tongue (HP:0000221)2.10303681
116Autoimmune hemolytic anemia (HP:0001890)2.09303273
117Methylmalonic acidemia (HP:0002912)2.09291178
118Lissencephaly (HP:0001339)2.03938972
119Increased corneal curvature (HP:0100692)2.02712904
120Keratoconus (HP:0000563)2.02712904
121Vitreoretinal degeneration (HP:0000655)2.02628199
122Polyuria (HP:0000103)2.02384779
123Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01968032
124Decreased central vision (HP:0007663)2.01673542
125Squamous cell carcinoma (HP:0002860)2.00367647
126Severe muscular hypotonia (HP:0006829)1.97874760
127Congenital hepatic fibrosis (HP:0002612)1.97263476
128Abnormality of the pons (HP:0007361)1.96817411
129Decreased circulating renin level (HP:0003351)1.95375780
130Arthralgia (HP:0002829)1.94922495
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94382630
132Abnormality of the ileum (HP:0001549)1.92545570
133Male pseudohermaphroditism (HP:0000037)1.91253062
134Abnormality of DNA repair (HP:0003254)1.91195080
135Hypoplasia of the pons (HP:0012110)1.90481870
136Meckel diverticulum (HP:0002245)1.90369520
137Ketosis (HP:0001946)1.89920169
138Impulsivity (HP:0100710)1.89889202
139Viral hepatitis (HP:0006562)1.89863589
140Increased CSF lactate (HP:0002490)1.89146355
14111 pairs of ribs (HP:0000878)1.89126754
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88662468
143Gait imbalance (HP:0002141)1.88281631
144Generalized hypopigmentation of hair (HP:0011358)1.88247871
145Mitochondrial inheritance (HP:0001427)1.88059254
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.87781050
147Abnormality of T cells (HP:0002843)1.87756732
148Clumsiness (HP:0002312)1.86496543
149Recurrent cutaneous fungal infections (HP:0011370)1.86171354
150Chronic mucocutaneous candidiasis (HP:0002728)1.86171354
151Abnormality of the femoral head (HP:0003368)1.86115609
152Methylmalonic aciduria (HP:0012120)1.85290687
153Clubbing of toes (HP:0100760)1.84688754
154Absent thumb (HP:0009777)1.84179925
155Broad-based gait (HP:0002136)1.83393535
156Bony spicule pigmentary retinopathy (HP:0007737)1.83001701
157Acute necrotizing encephalopathy (HP:0006965)1.82701962
158Congenital primary aphakia (HP:0007707)1.82231489
159Anencephaly (HP:0002323)1.81359704
160Agitation (HP:0000713)1.80252313
161Aplasia/hypoplasia of the uterus (HP:0008684)1.80005392
162Barrel-shaped chest (HP:0001552)1.79720058
163Abnormality of chromosome stability (HP:0003220)1.79683900
164Lipid accumulation in hepatocytes (HP:0006561)1.76425045
165Progressive macrocephaly (HP:0004481)1.76126957
166Absent speech (HP:0001344)1.75939744
167Vertebral clefting (HP:0008428)1.75740003
168Basal cell carcinoma (HP:0002671)1.75449841
169Chromsome breakage (HP:0040012)1.73715043
170Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73136035
171Hyperglycinuria (HP:0003108)1.73134561
172Postaxial foot polydactyly (HP:0001830)1.72984828
173Chorioretinal atrophy (HP:0000533)1.72527530
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.72417372
175Pachygyria (HP:0001302)1.72352611
176Aplasia/Hypoplasia of the spleen (HP:0010451)1.72117617
177Febrile seizures (HP:0002373)1.71163512
178Congenital sensorineural hearing impairment (HP:0008527)1.71052882
179Nephrogenic diabetes insipidus (HP:0009806)1.70906859
180Hypochromic anemia (HP:0001931)1.70847204
181Acute encephalopathy (HP:0006846)1.70479205
182Villous atrophy (HP:0011473)1.69695102
183Abnormality of small intestinal villus morphology (HP:0011472)1.69695102
1843-Methylglutaconic aciduria (HP:0003535)1.69571801
185Ulnar bowing (HP:0003031)1.69451482
186Recurrent fungal infections (HP:0002841)1.69002004
187Limited elbow extension (HP:0001377)1.66525946
188Cutaneous melanoma (HP:0012056)1.66446613
189Flat capital femoral epiphysis (HP:0003370)1.66183138
190Flat acetabular roof (HP:0003180)1.60673238
191Myocardial infarction (HP:0001658)1.58889862
192Combined immunodeficiency (HP:0005387)1.57644454
193Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.57271353
194Abnormality of the fingertips (HP:0001211)1.56158100
195Fibular hypoplasia (HP:0003038)1.55728951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.98243286
2BLK3.75073904
3PRKCH3.60783501
4ERN13.54456231
5PDK43.30684745
6PDK33.30684745
7SYK3.20867627
8ADRBK23.14138750
9PRKCI3.06494922
10TAOK33.04009457
11BMPR1B3.02130862
12ZAK3.01291659
13CSF1R2.97858146
14CDC72.86570643
15TESK12.76050116
16TLK12.55347400
17MAP4K22.48813885
18BUB12.45791227
19TXK2.42458330
20INSRR2.37085986
21PINK12.34683223
22WNK32.30003873
23PRKCQ2.24228305
24GRK62.23811495
25NEK22.22787687
26WNK42.16143746
27LYN1.81580925
28BTK1.79670860
29PDK21.78834176
30OXSR11.75702871
31STK101.68021311
32MAPK131.66287862
33STK391.57449621
34CCNB11.54581278
35EIF2AK31.53370147
36MAP3K101.52724882
37CASK1.50173578
38MAP3K41.47050087
39CAMKK21.44247744
40KIT1.40070116
41MST41.33002260
42RIPK41.28739836
43VRK11.23411088
44RPS6KA41.20526231
45ICK1.17092658
46DAPK21.06719908
47MKNK21.03719202
48PAK31.02636423
49ATR1.01944875
50ADRBK11.00988006
51CDK121.00129381
52BCKDK0.98974792
53CHEK20.98519164
54PTK2B0.97179491
55BRSK10.97030626
56BCR0.95853350
57LRRK20.94358597
58MAP3K140.91893955
59PRKCZ0.90211261
60PRKCG0.89707299
61DYRK20.87546580
62PIK3CG0.87488730
63TESK20.87142123
64TGFBR10.86773194
65PNCK0.86487487
66PRKCD0.84800253
67PLK20.84243081
68CLK10.80903189
69NME10.79765584
70DYRK30.79661925
71CDC42BPA0.79206638
72MAP2K70.78485123
73CSK0.78258435
74CHEK10.77601038
75TBK10.77192602
76PASK0.76917499
77CSNK1G20.74274440
78MAPKAPK30.73994119
79TAF10.73591095
80ITK0.72448682
81PDK10.71306486
82TNIK0.70992197
83TEC0.70943203
84TTK0.68134631
85RPS6KA50.66728939
86PLK40.64343543
87MAP2K60.63368446
88MAPKAPK50.60927157
89TIE10.59835525
90EIF2AK10.59730418
91PRKD30.59724126
92PIK3CA0.58619375
93NLK0.58142932
94CAMK1D0.57166320
95CSNK1G10.57128771
96MELK0.56568456
97IKBKE0.56502959
98WEE10.56366595
99PHKG10.55944823
100PHKG20.55944823
101PLK10.55480756
102CHUK0.55454911
103LCK0.54994493
104FGFR20.53414417
105IRAK10.52746717
106MAPK150.52516812
107STK30.51059815
108IKBKB0.50774763
109RPS6KB10.49792740
110CDK40.49494624
111TNK20.49424082
112NTRK30.49385059
113DYRK1B0.48680341
114MATK0.48490034
115PRKAA20.47613167
116ZAP700.47571625
117MARK30.47129583
118TRIM280.47059865
119STK240.46801675
120ALK0.46689557
121CSNK1A1L0.46137469
122CSNK1A10.45988307
123AURKB0.45652998
124HCK0.45600976
125CSNK1G30.45503521
126MUSK0.45058667
127PIM10.45019304
128MAPK110.43943989
129PRKACA0.43655150
130STK38L0.43015638
131MAP3K30.42979741
132AKT30.41780639
133MARK10.40974127
134PKN10.40617738
135ATM0.40189046
136STK110.39136847
137CSNK1D0.38495608
138CAMK10.38028385
139CAMK2A0.37380685
140AURKA0.36982432
141PRKAA10.36818384
142INSR0.36389403
143FGR0.35769663
144PLK30.35499457
145MAP2K40.34831657
146PRKCE0.34652272
147BRSK20.34451612
148SGK20.33380510
149CAMK1G0.33036519
150VRK20.30880943
151CDK20.30856740
152NEK90.30206066
153NEK10.29686068
154CSNK2A10.29397626
155ABL10.29219374
156MAPK70.28920924
157TRIB30.27958503
158GRK10.26947780
159NME20.25704067
160HIPK20.25065369
161MAPK120.24866960
162FRK0.24521773
163NUAK10.23785835
164ACVR1B0.22541765
165JAK10.22201925

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.24684205
2Base excision repair_Homo sapiens_hsa034104.73426261
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.70305536
4DNA replication_Homo sapiens_hsa030304.38984747
5Mismatch repair_Homo sapiens_hsa034304.36003302
6B cell receptor signaling pathway_Homo sapiens_hsa046624.33657266
7Caffeine metabolism_Homo sapiens_hsa002322.68989268
8Butanoate metabolism_Homo sapiens_hsa006502.53834035
9Homologous recombination_Homo sapiens_hsa034402.32903652
10Phototransduction_Homo sapiens_hsa047442.29737912
11Nitrogen metabolism_Homo sapiens_hsa009102.18755993
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.15281255
13Antigen processing and presentation_Homo sapiens_hsa046122.14000047
14Nucleotide excision repair_Homo sapiens_hsa034202.13999208
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06368274
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04004563
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01993814
18Fanconi anemia pathway_Homo sapiens_hsa034601.98747951
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96618885
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.80256232
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79406052
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72798363
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69734224
24Non-homologous end-joining_Homo sapiens_hsa034501.68052026
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66859377
26Ether lipid metabolism_Homo sapiens_hsa005651.63198547
27Retinol metabolism_Homo sapiens_hsa008301.61685568
28Oxidative phosphorylation_Homo sapiens_hsa001901.53196137
29Nicotine addiction_Homo sapiens_hsa050331.50564217
30RNA polymerase_Homo sapiens_hsa030201.45480462
31Proteasome_Homo sapiens_hsa030501.40736870
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38980720
33Cell cycle_Homo sapiens_hsa041101.34478014
34Fat digestion and absorption_Homo sapiens_hsa049751.31600491
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23546032
36Taste transduction_Homo sapiens_hsa047421.20216967
37ABC transporters_Homo sapiens_hsa020101.19350692
38Pyrimidine metabolism_Homo sapiens_hsa002401.18490329
39Peroxisome_Homo sapiens_hsa041461.15364300
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14592657
41Graft-versus-host disease_Homo sapiens_hsa053321.12131192
42Pyruvate metabolism_Homo sapiens_hsa006201.12043082
43Autoimmune thyroid disease_Homo sapiens_hsa053201.07437157
44Parkinsons disease_Homo sapiens_hsa050121.06848198
45Olfactory transduction_Homo sapiens_hsa047401.06803326
46Arachidonic acid metabolism_Homo sapiens_hsa005901.06510436
47One carbon pool by folate_Homo sapiens_hsa006701.05414008
48Vitamin B6 metabolism_Homo sapiens_hsa007501.04732081
49Pentose phosphate pathway_Homo sapiens_hsa000301.04422161
50Tryptophan metabolism_Homo sapiens_hsa003801.03954712
51Selenocompound metabolism_Homo sapiens_hsa004501.03778932
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.98458378
53RNA transport_Homo sapiens_hsa030130.96473527
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96018439
55Spliceosome_Homo sapiens_hsa030400.93752086
56Morphine addiction_Homo sapiens_hsa050320.93564278
57Hematopoietic cell lineage_Homo sapiens_hsa046400.90045189
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87587881
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87511495
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87061227
61p53 signaling pathway_Homo sapiens_hsa041150.84195450
62Basal transcription factors_Homo sapiens_hsa030220.84142866
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82994966
64Vitamin digestion and absorption_Homo sapiens_hsa049770.82819804
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82111018
66Systemic lupus erythematosus_Homo sapiens_hsa053220.80911379
67Histidine metabolism_Homo sapiens_hsa003400.79800550
68beta-Alanine metabolism_Homo sapiens_hsa004100.78471948
69Epstein-Barr virus infection_Homo sapiens_hsa051690.76915073
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76801815
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75630660
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75579118
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74934981
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73485551
75Serotonergic synapse_Homo sapiens_hsa047260.73062524
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72774596
77Herpes simplex infection_Homo sapiens_hsa051680.71534638
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.70195001
79HTLV-I infection_Homo sapiens_hsa051660.69975836
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69230119
81Insulin secretion_Homo sapiens_hsa049110.67739089
82Chemical carcinogenesis_Homo sapiens_hsa052040.66439497
83Fatty acid biosynthesis_Homo sapiens_hsa000610.65790108
84Propanoate metabolism_Homo sapiens_hsa006400.65159024
85Pancreatic secretion_Homo sapiens_hsa049720.64987852
86Biosynthesis of amino acids_Homo sapiens_hsa012300.63674756
87Lysine degradation_Homo sapiens_hsa003100.63228767
88Glucagon signaling pathway_Homo sapiens_hsa049220.63040857
89Oocyte meiosis_Homo sapiens_hsa041140.62311515
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62273287
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61368122
92Regulation of autophagy_Homo sapiens_hsa041400.61331965
93Shigellosis_Homo sapiens_hsa051310.59779928
94Osteoclast differentiation_Homo sapiens_hsa043800.59225886
95Protein export_Homo sapiens_hsa030600.58306681
96GABAergic synapse_Homo sapiens_hsa047270.57021627
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.56338146
98Ovarian steroidogenesis_Homo sapiens_hsa049130.54719593
99Metabolic pathways_Homo sapiens_hsa011000.53642268
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52967929
101mRNA surveillance pathway_Homo sapiens_hsa030150.52173204
102Viral carcinogenesis_Homo sapiens_hsa052030.51273264
103Alzheimers disease_Homo sapiens_hsa050100.50934247
104Huntingtons disease_Homo sapiens_hsa050160.49295700
105Purine metabolism_Homo sapiens_hsa002300.49032743
106Circadian entrainment_Homo sapiens_hsa047130.48364092
107Glutamatergic synapse_Homo sapiens_hsa047240.48171135
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47948767
109T cell receptor signaling pathway_Homo sapiens_hsa046600.46782653
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46568495
111Fatty acid degradation_Homo sapiens_hsa000710.45886493
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44974331
113Salivary secretion_Homo sapiens_hsa049700.44825394
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44717213
115Staphylococcus aureus infection_Homo sapiens_hsa051500.44575687
116Viral myocarditis_Homo sapiens_hsa054160.43886089
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43537209
118Cardiac muscle contraction_Homo sapiens_hsa042600.42791407
119Carbon metabolism_Homo sapiens_hsa012000.42694415
120Allograft rejection_Homo sapiens_hsa053300.42099337
121Calcium signaling pathway_Homo sapiens_hsa040200.41563291
122Apoptosis_Homo sapiens_hsa042100.39385319
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37753954
124Legionellosis_Homo sapiens_hsa051340.36918633
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35798356
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35119625
127Collecting duct acid secretion_Homo sapiens_hsa049660.35108561
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34301178
129Glutathione metabolism_Homo sapiens_hsa004800.34234641
130Ribosome_Homo sapiens_hsa030100.34135423
131Measles_Homo sapiens_hsa051620.33127652
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.32374327
133Type I diabetes mellitus_Homo sapiens_hsa049400.30477363
134Complement and coagulation cascades_Homo sapiens_hsa046100.30417806
135RNA degradation_Homo sapiens_hsa030180.27965050
136Sulfur relay system_Homo sapiens_hsa041220.27486242
137Asthma_Homo sapiens_hsa053100.27481659
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27245311
139N-Glycan biosynthesis_Homo sapiens_hsa005100.26146973
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25871535
141Sulfur metabolism_Homo sapiens_hsa009200.24514337
142Steroid biosynthesis_Homo sapiens_hsa001000.23958452
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23438973
144Phenylalanine metabolism_Homo sapiens_hsa003600.23296141
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21745109
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.21739657
147PPAR signaling pathway_Homo sapiens_hsa033200.21225785
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.20427267
149Hepatitis B_Homo sapiens_hsa051610.20353190
150Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20225440
151Inositol phosphate metabolism_Homo sapiens_hsa005620.19797716
152Tuberculosis_Homo sapiens_hsa051520.19507122
153Glycerolipid metabolism_Homo sapiens_hsa005610.18194717
154Linoleic acid metabolism_Homo sapiens_hsa005910.15936109
155Fructose and mannose metabolism_Homo sapiens_hsa000510.15246035
156Leishmaniasis_Homo sapiens_hsa051400.14086893
157Influenza A_Homo sapiens_hsa051640.13924539
158African trypanosomiasis_Homo sapiens_hsa051430.13483726
159Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.11592403
160Non-small cell lung cancer_Homo sapiens_hsa052230.10045264

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