NUFIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.01425420
2mitotic metaphase plate congression (GO:0007080)4.70623660
3purine nucleobase biosynthetic process (GO:0009113)4.66525761
4nucleobase biosynthetic process (GO:0046112)4.63732612
5ribosome assembly (GO:0042255)4.55235654
6establishment of integrated proviral latency (GO:0075713)4.46827246
7DNA replication initiation (GO:0006270)4.37103636
8DNA replication checkpoint (GO:0000076)4.36559694
9ribosome biogenesis (GO:0042254)4.21207151
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.21196246
11DNA strand elongation involved in DNA replication (GO:0006271)4.19219654
12formation of translation preinitiation complex (GO:0001731)4.18196782
13ribosomal large subunit biogenesis (GO:0042273)4.05837259
14DNA strand elongation (GO:0022616)4.01335459
15metaphase plate congression (GO:0051310)3.95566455
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95125362
17chaperone-mediated protein transport (GO:0072321)3.94350151
18ribonucleoprotein complex biogenesis (GO:0022613)3.93359337
19telomere maintenance via semi-conservative replication (GO:0032201)3.91665991
20CENP-A containing nucleosome assembly (GO:0034080)3.88911931
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.85379053
22chromatin remodeling at centromere (GO:0031055)3.84274100
23proteasome assembly (GO:0043248)3.77638960
24DNA unwinding involved in DNA replication (GO:0006268)3.75271550
25protein localization to kinetochore (GO:0034501)3.75059708
26rRNA processing (GO:0006364)3.70425563
27DNA deamination (GO:0045006)3.67329119
28ribosomal small subunit assembly (GO:0000028)3.67212702
29mitotic nuclear envelope disassembly (GO:0007077)3.64637653
30regulation of spindle organization (GO:0090224)3.63061644
31telomere maintenance via recombination (GO:0000722)3.62711229
32regulation of helicase activity (GO:0051095)3.60646881
33rRNA metabolic process (GO:0016072)3.60613534
34regulation of mitochondrial translation (GO:0070129)3.59366266
35nuclear pore organization (GO:0006999)3.55514283
36DNA replication-dependent nucleosome assembly (GO:0006335)3.54826356
37DNA replication-dependent nucleosome organization (GO:0034723)3.54826356
38IMP biosynthetic process (GO:0006188)3.54328446
39termination of RNA polymerase I transcription (GO:0006363)3.54275013
40DNA replication-independent nucleosome assembly (GO:0006336)3.50786592
41DNA replication-independent nucleosome organization (GO:0034724)3.50786592
42transcription elongation from RNA polymerase I promoter (GO:0006362)3.49947488
43spliceosomal snRNP assembly (GO:0000387)3.49332404
44protein K6-linked ubiquitination (GO:0085020)3.48202851
45DNA ligation (GO:0006266)3.45043917
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.44487865
47mitotic recombination (GO:0006312)3.42619275
48folic acid-containing compound biosynthetic process (GO:0009396)3.42510189
49establishment of chromosome localization (GO:0051303)3.41068103
50kinetochore organization (GO:0051383)3.38496447
51transcription-coupled nucleotide-excision repair (GO:0006283)3.36550137
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36288983
53negative regulation of ligase activity (GO:0051352)3.36288983
54translational termination (GO:0006415)3.33481453
55telomere maintenance via telomere lengthening (GO:0010833)3.33371580
56nuclear envelope disassembly (GO:0051081)3.32934502
57membrane disassembly (GO:0030397)3.32934502
58histone exchange (GO:0043486)3.31081465
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.30152859
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30152859
61viral transcription (GO:0019083)3.30150742
62nuclear pore complex assembly (GO:0051292)3.29661004
63ribosomal small subunit biogenesis (GO:0042274)3.29082469
647-methylguanosine mRNA capping (GO:0006370)3.28336876
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.28121508
66termination of RNA polymerase III transcription (GO:0006386)3.28121508
67kinetochore assembly (GO:0051382)3.27516262
68protein localization to chromosome, centromeric region (GO:0071459)3.27001884
69translational initiation (GO:0006413)3.26874924
70establishment of viral latency (GO:0019043)3.24493231
71maturation of 5.8S rRNA (GO:0000460)3.23611283
72transcription from RNA polymerase I promoter (GO:0006360)3.23158334
73rRNA modification (GO:0000154)3.23118084
747-methylguanosine RNA capping (GO:0009452)3.22512066
75RNA capping (GO:0036260)3.22512066
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19972884
77regulation of mitotic spindle checkpoint (GO:1903504)3.19972884
78ATP synthesis coupled proton transport (GO:0015986)3.19449552
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19449552
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19138497
81pseudouridine synthesis (GO:0001522)3.18689242
82DNA double-strand break processing (GO:0000729)3.17872543
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16418618
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.13085201
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12241948
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12161545
87rRNA methylation (GO:0031167)3.11368393
88spindle checkpoint (GO:0031577)3.10653123
89cullin deneddylation (GO:0010388)3.10074074
90IMP metabolic process (GO:0046040)3.09514195
91attachment of spindle microtubules to kinetochore (GO:0008608)3.07884532
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07719018
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07352483
94regulation of centrosome cycle (GO:0046605)3.06545046
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06519209
96mitochondrial RNA metabolic process (GO:0000959)3.05917691
97transcription initiation from RNA polymerase I promoter (GO:0006361)3.05846096
98folic acid metabolic process (GO:0046655)3.04435934
99DNA catabolic process, exonucleolytic (GO:0000738)3.04253071
100translational elongation (GO:0006414)3.02615368
101DNA damage response, detection of DNA damage (GO:0042769)3.02021120
102sister chromatid segregation (GO:0000819)3.00474593
103negative regulation of chromosome segregation (GO:0051985)3.00338885
104mitotic sister chromatid segregation (GO:0000070)2.99816267
105respiratory chain complex IV assembly (GO:0008535)2.99368684
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98609228
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98379371
108cell cycle G1/S phase transition (GO:0044843)2.98181127
109G1/S transition of mitotic cell cycle (GO:0000082)2.98181127
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.97945436
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97469468
112negative regulation of sister chromatid segregation (GO:0033046)2.97469468
113negative regulation of mitotic sister chromatid separation (GO:2000816)2.97469468
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97469468
115mitotic spindle checkpoint (GO:0071174)2.95353922
116regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95220543
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95220543
118positive regulation of chromosome segregation (GO:0051984)2.95195266
119double-strand break repair via nonhomologous end joining (GO:0006303)2.94332931
120non-recombinational repair (GO:0000726)2.94332931
121DNA-templated transcription, termination (GO:0006353)2.94157955
122regulation of mitotic spindle organization (GO:0060236)2.93334591
123transcription from mitochondrial promoter (GO:0006390)2.93097033
124protein targeting to mitochondrion (GO:0006626)2.92704110
125heterochromatin organization (GO:0070828)2.92630614
126ncRNA processing (GO:0034470)2.92446858
127positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91663138
128meiotic chromosome segregation (GO:0045132)2.91272404
129mismatch repair (GO:0006298)2.90632140
130histone mRNA metabolic process (GO:0008334)2.90063583
131tRNA methylation (GO:0030488)2.89724556
132cellular component biogenesis (GO:0044085)2.89636475
133mitochondrial respiratory chain complex assembly (GO:0033108)2.89267009
134regulation of chromosome segregation (GO:0051983)2.89244981
135nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89122461
136mitotic spindle assembly checkpoint (GO:0007094)2.89010055
137regulation of sister chromatid segregation (GO:0033045)2.87246788
138regulation of mitotic sister chromatid separation (GO:0010965)2.87246788
139regulation of mitotic sister chromatid segregation (GO:0033047)2.87246788
140spindle assembly checkpoint (GO:0071173)2.86867951
141protein deneddylation (GO:0000338)2.86626104
142mitotic chromosome condensation (GO:0007076)2.84982858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.17327734
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.58773977
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.74787007
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66794948
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44508454
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39896404
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24370365
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11500283
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07179947
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.05302444
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03854622
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.03756558
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98545415
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93795719
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.92652735
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78988386
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49978467
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45894857
19VDR_23849224_ChIP-Seq_CD4+_Human2.40812729
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40757357
21XRN2_22483619_ChIP-Seq_HELA_Human2.28462548
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22802645
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07098980
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06822229
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06205944
26AR_21909140_ChIP-Seq_LNCAP_Human2.05075013
27FOXP3_21729870_ChIP-Seq_TREG_Human2.03568556
28DCP1A_22483619_ChIP-Seq_HELA_Human2.01743950
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98041190
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97034734
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96233093
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96197738
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.92431391
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92062759
35GABP_19822575_ChIP-Seq_HepG2_Human1.87859546
36TTF2_22483619_ChIP-Seq_HELA_Human1.86332261
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85504885
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.79442157
39ELK1_19687146_ChIP-ChIP_HELA_Human1.76610054
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75613763
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72311031
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72047147
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70317547
44* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69663392
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65886747
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65070366
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.63505307
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55518063
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.55265836
50EWS_26573619_Chip-Seq_HEK293_Human1.49720415
51KDM5A_27292631_Chip-Seq_BREAST_Human1.48935273
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.48911615
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46756941
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45625819
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45215617
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43325092
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41751645
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41256168
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.40890242
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35250235
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29406549
62CIITA_25753668_ChIP-Seq_RAJI_Human1.28855332
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27165525
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26942620
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.25717200
66ZNF274_21170338_ChIP-Seq_K562_Hela1.24248672
67FUS_26573619_Chip-Seq_HEK293_Human1.21465639
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21331997
69* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20825539
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.20068426
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.19752686
72TFEB_21752829_ChIP-Seq_HELA_Human1.13943926
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13685906
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13520954
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13074068
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13074068
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13074068
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12754487
79MYC_18940864_ChIP-ChIP_HL60_Human1.12081230
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11674476
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10885072
82MYC_22102868_ChIP-Seq_BL_Human1.08296429
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07759094
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07482786
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07397151
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06589072
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03855779
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03665096
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02628957
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02363287
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02320173
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99819266
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98785599
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98540125
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98350149
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98271015
97VDR_22108803_ChIP-Seq_LS180_Human0.97957690
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.97764608
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96592839
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94519078
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.92025329
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.90692065
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90426038
104IGF1R_20145208_ChIP-Seq_DFB_Human0.90306370
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89978260
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89118959
107SPI1_23547873_ChIP-Seq_NB4_Human0.86431346
108* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85719469
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84949267
110* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84681818
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.81202070
112IRF1_19129219_ChIP-ChIP_H3396_Human0.79434542
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78690559
114TAF15_26573619_Chip-Seq_HEK293_Human0.78451226
115TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78215120
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77834862
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74280319
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68411255
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.64865052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.01145706
2MP0008057_abnormal_DNA_replication4.84786517
3MP0010094_abnormal_chromosome_stability4.71428901
4MP0003111_abnormal_nucleus_morphology4.67467223
5MP0004957_abnormal_blastocyst_morpholog4.43332874
6MP0003077_abnormal_cell_cycle4.13158884
7MP0008058_abnormal_DNA_repair3.98077976
8MP0008007_abnormal_cellular_replicative2.88241744
9MP0008932_abnormal_embryonic_tissue2.65769167
10MP0010307_abnormal_tumor_latency2.51298697
11MP0003123_paternal_imprinting2.42360582
12MP0003786_premature_aging2.40613771
13MP0008877_abnormal_DNA_methylation2.27215713
14MP0002396_abnormal_hematopoietic_system2.21072966
15MP0001730_embryonic_growth_arrest2.20528419
16MP0000350_abnormal_cell_proliferation2.20256473
17MP0003718_maternal_effect2.20045318
18MP0006292_abnormal_olfactory_placode2.13029743
19MP0001672_abnormal_embryogenesis/_devel1.71810523
20MP0005380_embryogenesis_phenotype1.71810523
21MP0002102_abnormal_ear_morphology1.66461711
22MP0001697_abnormal_embryo_size1.60514698
23MP0009333_abnormal_splenocyte_physiolog1.58549895
24MP0008789_abnormal_olfactory_epithelium1.51473987
25MP0003941_abnormal_skin_development1.49723047
26MP0002080_prenatal_lethality1.49231632
27MP0000313_abnormal_cell_death1.47204889
28MP0000490_abnormal_crypts_of1.46752204
29MP0001293_anophthalmia1.44979840
30MP0006035_abnormal_mitochondrial_morpho1.44262924
31MP0003984_embryonic_growth_retardation1.42258870
32MP0002210_abnormal_sex_determination1.41631999
33MP0002085_abnormal_embryonic_tissue1.41413623
34MP0002019_abnormal_tumor_incidence1.40871907
35MP0002088_abnormal_embryonic_growth/wei1.39883341
36MP0010352_gastrointestinal_tract_polyps1.39279627
37MP0006036_abnormal_mitochondrial_physio1.37373501
38MP0006072_abnormal_retinal_apoptosis1.34620227
39MP0004808_abnormal_hematopoietic_stem1.33980811
40MP0002084_abnormal_developmental_patter1.27744110
41MP0002086_abnormal_extraembryonic_tissu1.25827434
42MP0001145_abnormal_male_reproductive1.24983649
43MP0003121_genomic_imprinting1.21107188
44MP0004197_abnormal_fetal_growth/weight/1.19713375
45MP0000566_synostosis1.17789041
46MP0002234_abnormal_pharynx_morphology1.16997975
47MP0003567_abnormal_fetal_cardiomyocyte1.16774301
48MP0003890_abnormal_embryonic-extraembry1.15846613
49MP0002233_abnormal_nose_morphology1.15501673
50MP0003763_abnormal_thymus_physiology1.12476397
51MP0001929_abnormal_gametogenesis1.10883387
52MP0001545_abnormal_hematopoietic_system1.10035981
53MP0005397_hematopoietic_system_phenotyp1.10035981
54MP0002160_abnormal_reproductive_system1.08566632
55MP0003315_abnormal_perineum_morphology1.05938971
56MP0000653_abnormal_sex_gland1.05901325
57MP0005394_taste/olfaction_phenotype1.05884764
58MP0005499_abnormal_olfactory_system1.05884764
59MP0002697_abnormal_eye_size1.05611159
60MP0000049_abnormal_middle_ear1.05362958
61MP0003136_yellow_coat_color1.05240784
62MP0000703_abnormal_thymus_morphology1.04268116
63MP0002398_abnormal_bone_marrow1.02529165
64MP0002736_abnormal_nociception_after1.02510118
65MP0002722_abnormal_immune_system0.97674080
66MP0000689_abnormal_spleen_morphology0.97028530
67MP0002132_abnormal_respiratory_system0.95795517
68MP0003806_abnormal_nucleotide_metabolis0.94925806
69MP0001188_hyperpigmentation0.94656244
70MP0001984_abnormal_olfaction0.93925791
71MP0002938_white_spotting0.93741471
72MP0003011_delayed_dark_adaptation0.92978943
73MP0002090_abnormal_vision0.91647122
74MP0002751_abnormal_autonomic_nervous0.91388459
75MP0001119_abnormal_female_reproductive0.88614653
76MP0001346_abnormal_lacrimal_gland0.86932809
77MP0005389_reproductive_system_phenotype0.86317449
78MP0001727_abnormal_embryo_implantation0.86218171
79MP0004133_heterotaxia0.85876367
80MP0002277_abnormal_respiratory_mucosa0.85107670
81MP0000372_irregular_coat_pigmentation0.84889346
82MP0003755_abnormal_palate_morphology0.84164790
83MP0002161_abnormal_fertility/fecundity0.82436451
84MP0003119_abnormal_digestive_system0.82250298
85MP0003186_abnormal_redox_activity0.81820400
86MP0001835_abnormal_antigen_presentation0.81760685
87MP0002163_abnormal_gland_morphology0.80887606
88MP0000858_altered_metastatic_potential0.80502892
89MP0008995_early_reproductive_senescence0.80015992
90MP0003937_abnormal_limbs/digits/tail_de0.79524923
91MP0002429_abnormal_blood_cell0.79283449
92MP0000631_abnormal_neuroendocrine_gland0.78651991
93MP0000358_abnormal_cell_content/0.78002388
94MP0010030_abnormal_orbit_morphology0.77546952
95MP0005384_cellular_phenotype0.74724721
96MP0000647_abnormal_sebaceous_gland0.74515122
97MP0009697_abnormal_copulation0.74355215
98MP0005391_vision/eye_phenotype0.74090253
99MP0009703_decreased_birth_body0.73996664
100MP0001529_abnormal_vocalization0.72558293
101MP0005621_abnormal_cell_physiology0.71043682
102MP0000537_abnormal_urethra_morphology0.70897451
103MP0000716_abnormal_immune_system0.70568024
104MP0000762_abnormal_tongue_morphology0.70250264
105MP0005253_abnormal_eye_physiology0.70160479
106MP0005084_abnormal_gallbladder_morpholo0.69680231
107MP0003861_abnormal_nervous_system0.68663022
108MP0005075_abnormal_melanosome_morpholog0.68394661
109MP0000428_abnormal_craniofacial_morphol0.67806744
110MP0008260_abnormal_autophagy0.67241109
111MP0005410_abnormal_fertilization0.66824836
112MP0001881_abnormal_mammary_gland0.66688592
113MP0001299_abnormal_eye_distance/0.66456730
114MP0002111_abnormal_tail_morphology0.66049159
115MP0001286_abnormal_eye_development0.65133284
116MP0009672_abnormal_birth_weight0.64866746
117MP0002092_abnormal_eye_morphology0.64541037
118MP0002254_reproductive_system_inflammat0.63812813
119MP0001800_abnormal_humoral_immune0.63294361
120MP0005076_abnormal_cell_differentiation0.63203409
121MP0003448_altered_tumor_morphology0.63110198
122MP0002282_abnormal_trachea_morphology0.61814530
123MP0005379_endocrine/exocrine_gland_phen0.61493072
124MP0001919_abnormal_reproductive_system0.60334796
125MP0000627_abnormal_mammary_gland0.60272693
126MP0001853_heart_inflammation0.59994705
127MP0005395_other_phenotype0.59984899
128MP0003936_abnormal_reproductive_system0.59605449
129MP0002452_abnormal_antigen_presenting0.57606499
130MP0005671_abnormal_response_to0.55206547
131MP0001819_abnormal_immune_cell0.54603234
132MP0002420_abnormal_adaptive_immunity0.54571097
133MP0003698_abnormal_male_reproductive0.54490542
134MP0002723_abnormal_immune_serum0.53410015
135MP0003878_abnormal_ear_physiology0.52326374
136MP0005377_hearing/vestibular/ear_phenot0.52326374
137MP0003699_abnormal_female_reproductive0.51547377
138MP0002405_respiratory_system_inflammati0.51268486
139MP0009379_abnormal_foot_pigmentation0.50408732

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.71881282
2Breast hypoplasia (HP:0003187)4.57717128
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.31992077
4Chromsome breakage (HP:0040012)4.29651851
5Increased hepatocellular lipid droplets (HP:0006565)3.86496429
6Reticulocytopenia (HP:0001896)3.75706224
7Acute necrotizing encephalopathy (HP:0006965)3.68507106
8Patellar aplasia (HP:0006443)3.63614327
9Abnormality of the preputium (HP:0100587)3.54406833
10Abnormality of chromosome stability (HP:0003220)3.43989981
11Acute encephalopathy (HP:0006846)3.43014097
12Abnormality of cells of the erythroid lineage (HP:0012130)3.42888065
13Meckel diverticulum (HP:0002245)3.41478670
14Lipid accumulation in hepatocytes (HP:0006561)3.40767541
15Aplasia/Hypoplasia of the patella (HP:0006498)3.39647047
16Rough bone trabeculation (HP:0100670)3.27342567
17Abnormal mitochondria in muscle tissue (HP:0008316)3.27293576
18Abnormality of the ileum (HP:0001549)3.26334623
19Abnormality of the labia minora (HP:0012880)3.25956502
20Oral leukoplakia (HP:0002745)3.25745274
21Carpal bone hypoplasia (HP:0001498)3.20939404
22Supernumerary spleens (HP:0009799)3.20540753
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.18230091
24Increased CSF lactate (HP:0002490)3.16624339
25Colon cancer (HP:0003003)3.14919542
26Mitochondrial inheritance (HP:0001427)3.13288062
27Abnormal number of erythroid precursors (HP:0012131)3.12636837
28Absent radius (HP:0003974)3.08370083
29Impulsivity (HP:0100710)3.05145814
30Progressive macrocephaly (HP:0004481)3.04158046
31Microvesicular hepatic steatosis (HP:0001414)3.02202329
32Cerebral hypomyelination (HP:0006808)2.97482435
33Absent thumb (HP:0009777)2.92206601
34Agnosia (HP:0010524)2.88452956
35Myelodysplasia (HP:0002863)2.87583298
36Aplasia involving forearm bones (HP:0009822)2.87398664
37Absent forearm bone (HP:0003953)2.87398664
38Medulloblastoma (HP:0002885)2.85810409
39Macrocytic anemia (HP:0001972)2.83140062
40Selective tooth agenesis (HP:0001592)2.81222045
41Abnormality of DNA repair (HP:0003254)2.80803134
42Renal Fanconi syndrome (HP:0001994)2.75496305
43Aplastic anemia (HP:0001915)2.70991144
44Abnormal trabecular bone morphology (HP:0100671)2.65000355
45Entropion (HP:0000621)2.63963006
46Abnormality of the anterior horn cell (HP:0006802)2.63464025
47Degeneration of anterior horn cells (HP:0002398)2.63464025
48Ependymoma (HP:0002888)2.61525776
49Duodenal stenosis (HP:0100867)2.61280958
50Small intestinal stenosis (HP:0012848)2.61280958
51Cerebral edema (HP:0002181)2.60920456
52Pallor (HP:0000980)2.59143716
53Bone marrow hypocellularity (HP:0005528)2.57100910
54Premature graying of hair (HP:0002216)2.57081175
55Microretrognathia (HP:0000308)2.54946060
56Rhabdomyosarcoma (HP:0002859)2.54244362
57Abnormality of methionine metabolism (HP:0010901)2.52636933
58Hepatocellular necrosis (HP:0001404)2.52003710
59Triphalangeal thumb (HP:0001199)2.46270989
60Increased serum lactate (HP:0002151)2.45152194
61Horseshoe kidney (HP:0000085)2.42113329
62Methylmalonic acidemia (HP:0002912)2.41717605
63Cleft eyelid (HP:0000625)2.39953816
64Neoplasm of the pancreas (HP:0002894)2.39095855
65Hepatic necrosis (HP:0002605)2.37952902
66Sloping forehead (HP:0000340)2.35593026
67Poikiloderma (HP:0001029)2.32989600
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32407556
69Respiratory difficulties (HP:0002880)2.30905071
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30827826
71Septo-optic dysplasia (HP:0100842)2.27952005
72Cellular immunodeficiency (HP:0005374)2.27897706
73Tracheoesophageal fistula (HP:0002575)2.26424116
7411 pairs of ribs (HP:0000878)2.24709769
75Abnormal lung lobation (HP:0002101)2.23050698
76Ectopic kidney (HP:0000086)2.22243722
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21403209
78Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21403209
79Progressive muscle weakness (HP:0003323)2.18171686
80Abnormality of the duodenum (HP:0002246)2.17579278
81Volvulus (HP:0002580)2.12733944
82Lactic acidosis (HP:0003128)2.12660445
83Increased intramyocellular lipid droplets (HP:0012240)2.10892746
84Stenosis of the external auditory canal (HP:0000402)2.10005860
85Exercise intolerance (HP:0003546)2.09714763
86Duplicated collecting system (HP:0000081)2.08412109
87Hypoplasia of the pons (HP:0012110)2.08360442
88Premature ovarian failure (HP:0008209)2.06723256
89Abnormal number of incisors (HP:0011064)2.06583120
90Abnormal glycosylation (HP:0012345)2.05694956
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05694956
92Abnormal protein N-linked glycosylation (HP:0012347)2.05694956
93Abnormal protein glycosylation (HP:0012346)2.05694956
94Pendular nystagmus (HP:0012043)2.04446572
95Facial hemangioma (HP:0000329)2.04162640
96Abnormality of the pons (HP:0007361)2.02842498
97Clubbing of toes (HP:0100760)2.02265714
98Atresia of the external auditory canal (HP:0000413)2.02168157
99Prominent nose (HP:0000448)2.01517056
100Ureteral duplication (HP:0000073)1.99150485
101Short thumb (HP:0009778)1.98934379
102Lymphoma (HP:0002665)1.98628580
103Abnormal spermatogenesis (HP:0008669)1.98476594
104Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97904089
105Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95954586
106Megaloblastic anemia (HP:0001889)1.94900381
107Abnormality of the septum pellucidum (HP:0007375)1.94411770
108Squamous cell carcinoma (HP:0002860)1.93499431
109Bifid tongue (HP:0010297)1.93095688
110Bilateral microphthalmos (HP:0007633)1.92766883
111Nephroblastoma (Wilms tumor) (HP:0002667)1.92583739
112Hyperglycinemia (HP:0002154)1.91953826
113Breast aplasia (HP:0100783)1.91516525
114Basal cell carcinoma (HP:0002671)1.90863704
115Pancytopenia (HP:0001876)1.90455292
116Type I transferrin isoform profile (HP:0003642)1.90271865
117IgG deficiency (HP:0004315)1.88522106
118Facial cleft (HP:0002006)1.88380550
119Absent septum pellucidum (HP:0001331)1.88120235
120Secondary amenorrhea (HP:0000869)1.87989197
121Hypoplasia of the radius (HP:0002984)1.87779479
122Abnormality of serum amino acid levels (HP:0003112)1.86776831
123Exertional dyspnea (HP:0002875)1.86449291
124Abnormality of abdominal situs (HP:0011620)1.86289664
125Abdominal situs inversus (HP:0003363)1.86289664
126Leukodystrophy (HP:0002415)1.85397478
127Methylmalonic aciduria (HP:0012120)1.85292288
128Abnormality of the renal collecting system (HP:0004742)1.84671743
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84045954
130Hyperalaninemia (HP:0003348)1.83844136
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83844136
132Abnormality of alanine metabolism (HP:0010916)1.83844136
133Abnormality of the carotid arteries (HP:0005344)1.83761546
134Cafe-au-lait spot (HP:0000957)1.83176458
135Asplenia (HP:0001746)1.82298492
136CNS hypomyelination (HP:0003429)1.81795129
137Trismus (HP:0000211)1.81728172
138Respiratory failure (HP:0002878)1.81676765
139Homocystinuria (HP:0002156)1.79252885
140Abnormality of homocysteine metabolism (HP:0010919)1.79252885
141Amaurosis fugax (HP:0100576)1.79122999
142Biliary tract neoplasm (HP:0100574)1.78812030
143Embryonal renal neoplasm (HP:0011794)1.78433097
144Abnormality of pyrimidine metabolism (HP:0004353)1.77806107
145Sparse lateral eyebrow (HP:0005338)1.77350278
146Progressive external ophthalmoplegia (HP:0000590)1.76866830
147Reduced antithrombin III activity (HP:0001976)1.76130027
148Sparse eyelashes (HP:0000653)1.75055466
149Aplasia/Hypoplasia of the breasts (HP:0010311)1.74780984
150Prominent metopic ridge (HP:0005487)1.74385539
151Hypoglycemic coma (HP:0001325)1.73819924
152Multiple enchondromatosis (HP:0005701)1.73636846
153Neoplasm of the colon (HP:0100273)1.72446428
154Pancreatic islet-cell hyperplasia (HP:0004510)1.70849693
155Thrombocytosis (HP:0001894)1.70458609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.13829644
2WEE14.61088726
3VRK23.80433114
4CDC73.65649496
5EIF2AK13.65552691
6SRPK12.96170670
7STK162.84856986
8TAF12.69310987
9NEK22.63503390
10NME22.45009842
11TSSK62.39660084
12DYRK32.39444459
13PLK42.26557466
14TTK2.24198155
15EIF2AK32.23264508
16MKNK22.15036589
17BRSK22.06324634
18TLK12.05596323
19EPHA22.04192761
20PLK12.03623688
21MKNK12.03494520
22ACVR1B1.84664209
23VRK11.80949100
24RPS6KA41.79682539
25CDK71.73217232
26TRIM281.67718796
27PLK31.66601020
28NME11.59195144
29AURKB1.55778129
30ATR1.54103696
31CHEK21.53670517
32ZAK1.53326900
33CDK121.51910049
34BRAF1.44340421
35TNIK1.42499568
36BMPR1B1.32919066
37WNK31.25252817
38MAP3K81.21717860
39EIF2AK21.20125084
40STK38L1.19319727
41AURKA1.19281680
42RPS6KB21.18875226
43CHEK11.14027045
44TESK21.12097826
45PASK1.11421959
46CDK41.10633129
47PNCK1.08028526
48PIM21.00744672
49MAP3K101.00193359
50BRSK10.98509313
51NEK10.98300684
52ATM0.89548974
53STK40.88963695
54MAP3K40.87806983
55CDK190.86542946
56RPS6KA50.84456941
57AKT30.84229083
58IRAK30.84159047
59CDK80.83741348
60PIM10.83460231
61SCYL20.82036874
62CDK20.80526570
63STK30.79250390
64CSNK1G20.77763302
65PBK0.74607941
66CSNK2A20.73380719
67TGFBR10.71468494
68DYRK20.70808496
69CSNK2A10.69061905
70CCNB10.68915177
71BRD40.68480858
72MAP3K90.68174343
73FLT30.64862154
74STK100.64084109
75MARK30.61672890
76DAPK10.61396138
77MAP4K20.60453827
78ALK0.59239423
79CDK10.58726657
80ERBB40.58545735
81BCKDK0.55799542
82PRKCI0.55208709
83ARAF0.53553718
84CSNK1A1L0.53445595
85TXK0.52287985
86MAP3K110.51863779
87PAK10.50498063
88OXSR10.50291911
89MAP2K70.49342129
90PLK20.49104109
91FGFR10.49044913
92MAP4K10.47585652
93TEC0.46283423
94CDK90.44084348
95EPHA40.42905197
96SMG10.41491649
97STK240.41385133
98RAF10.41372563
99YES10.41340016
100PAK40.40330105
101MST40.39532519
102GRK10.39008098
103STK390.38926460
104CSNK1E0.38839980
105LATS20.37106594
106MELK0.36729304
107BCR0.36502642
108LATS10.35105977
109IRAK40.34613583
110IKBKB0.34539637
111ERBB30.32834108
112CDK60.32476016
113PRKCG0.31063035
114TAOK20.30294651
115BLK0.30193552
116MAP3K120.30163159
117PRKDC0.27337428
118ZAP700.25842328
119CSNK1A10.24467444
120CDK30.23838869
121LIMK10.23578573
122MAP3K50.23398930
123CSNK1G10.21311812
124NUAK10.20524002
125JAK30.20263316
126CSNK1G30.19930336
127AKT20.19639881
128MAPK140.19291702
129KDR0.18241806
130ABL20.18114347
131CLK10.17949126
132AKT10.15149167
133PDK20.13688507

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.38126753
2DNA replication_Homo sapiens_hsa030304.37617822
3Mismatch repair_Homo sapiens_hsa034303.94158803
4RNA polymerase_Homo sapiens_hsa030203.90188760
5Proteasome_Homo sapiens_hsa030503.39183326
6Ribosome_Homo sapiens_hsa030103.38520043
7Spliceosome_Homo sapiens_hsa030403.27129190
8RNA transport_Homo sapiens_hsa030133.23548529
9Homologous recombination_Homo sapiens_hsa034402.94271304
10Nucleotide excision repair_Homo sapiens_hsa034202.93935010
11Base excision repair_Homo sapiens_hsa034102.72522197
12Pyrimidine metabolism_Homo sapiens_hsa002402.59241359
13Cell cycle_Homo sapiens_hsa041102.57978130
14Basal transcription factors_Homo sapiens_hsa030222.56994766
15Fanconi anemia pathway_Homo sapiens_hsa034602.41265764
16One carbon pool by folate_Homo sapiens_hsa006702.41158160
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20350262
18Non-homologous end-joining_Homo sapiens_hsa034501.94783508
19RNA degradation_Homo sapiens_hsa030181.88958062
20mRNA surveillance pathway_Homo sapiens_hsa030151.71437783
21p53 signaling pathway_Homo sapiens_hsa041151.62765380
22Vitamin B6 metabolism_Homo sapiens_hsa007501.61207018
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57215804
24Purine metabolism_Homo sapiens_hsa002301.44368401
25Propanoate metabolism_Homo sapiens_hsa006401.33946851
26Epstein-Barr virus infection_Homo sapiens_hsa051691.30233993
27Alzheimers disease_Homo sapiens_hsa050101.28562466
28Pyruvate metabolism_Homo sapiens_hsa006201.26926169
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23540100
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21380797
31Steroid biosynthesis_Homo sapiens_hsa001001.19442955
32Folate biosynthesis_Homo sapiens_hsa007901.13671506
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12870229
34Systemic lupus erythematosus_Homo sapiens_hsa053221.11241668
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08931644
36Herpes simplex infection_Homo sapiens_hsa051681.07271406
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04226341
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03910158
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01883031
40Fatty acid elongation_Homo sapiens_hsa000620.99727755
41Antigen processing and presentation_Homo sapiens_hsa046120.97277378
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87009150
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.86073339
44Oocyte meiosis_Homo sapiens_hsa041140.85327630
45Viral carcinogenesis_Homo sapiens_hsa052030.83772532
46Selenocompound metabolism_Homo sapiens_hsa004500.82866648
47Carbon metabolism_Homo sapiens_hsa012000.77704511
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76573303
49Cardiac muscle contraction_Homo sapiens_hsa042600.75146915
50Pentose phosphate pathway_Homo sapiens_hsa000300.74980296
51Protein export_Homo sapiens_hsa030600.71731700
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71608586
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.70692641
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.65005970
55Regulation of autophagy_Homo sapiens_hsa041400.64878267
56Legionellosis_Homo sapiens_hsa051340.63089433
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62704410
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59934131
59HTLV-I infection_Homo sapiens_hsa051660.57478148
60Biosynthesis of amino acids_Homo sapiens_hsa012300.54246266
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52580385
62MicroRNAs in cancer_Homo sapiens_hsa052060.51812339
63Thyroid cancer_Homo sapiens_hsa052160.51798993
64Measles_Homo sapiens_hsa051620.51734575
65Glutathione metabolism_Homo sapiens_hsa004800.48798785
66Huntingtons disease_Homo sapiens_hsa050160.47404226
67Primary immunodeficiency_Homo sapiens_hsa053400.47003752
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46080116
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.44242104
70Allograft rejection_Homo sapiens_hsa053300.42759490
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42442031
72Apoptosis_Homo sapiens_hsa042100.42403499
73Sulfur relay system_Homo sapiens_hsa041220.42146575
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42131093
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41428748
76Butanoate metabolism_Homo sapiens_hsa006500.41072796
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39232610
78Wnt signaling pathway_Homo sapiens_hsa043100.38229581
79Hepatitis B_Homo sapiens_hsa051610.37774306
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.36566432
81Graft-versus-host disease_Homo sapiens_hsa053320.35887271
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35825242
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35620080
84Asthma_Homo sapiens_hsa053100.35503538
85Peroxisome_Homo sapiens_hsa041460.35467601
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35462115
87Influenza A_Homo sapiens_hsa051640.34940496
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34469375
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32571277
90Caffeine metabolism_Homo sapiens_hsa002320.32292505
91Small cell lung cancer_Homo sapiens_hsa052220.31213989
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30417430
93Fatty acid metabolism_Homo sapiens_hsa012120.29904768
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28380895
95Alcoholism_Homo sapiens_hsa050340.28259832
96Hematopoietic cell lineage_Homo sapiens_hsa046400.27775479
97Fructose and mannose metabolism_Homo sapiens_hsa000510.27057833
98Phototransduction_Homo sapiens_hsa047440.26970435
99TGF-beta signaling pathway_Homo sapiens_hsa043500.26921424
100Hedgehog signaling pathway_Homo sapiens_hsa043400.24528413
101Colorectal cancer_Homo sapiens_hsa052100.23698778
102Metabolic pathways_Homo sapiens_hsa011000.23287875
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.21697378
104beta-Alanine metabolism_Homo sapiens_hsa004100.21451078
105Autoimmune thyroid disease_Homo sapiens_hsa053200.21421592
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19480739
107Hippo signaling pathway_Homo sapiens_hsa043900.19475933
108Arachidonic acid metabolism_Homo sapiens_hsa005900.18324368
109Collecting duct acid secretion_Homo sapiens_hsa049660.18106141
110HIF-1 signaling pathway_Homo sapiens_hsa040660.17497749
111Shigellosis_Homo sapiens_hsa051310.17390337
112Acute myeloid leukemia_Homo sapiens_hsa052210.17241059
113Prostate cancer_Homo sapiens_hsa052150.17074192
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.16740926
115Olfactory transduction_Homo sapiens_hsa047400.15410275
116Arginine and proline metabolism_Homo sapiens_hsa003300.15112868
117Vitamin digestion and absorption_Homo sapiens_hsa049770.14962581
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14335276
119N-Glycan biosynthesis_Homo sapiens_hsa005100.12849882
120Adherens junction_Homo sapiens_hsa045200.12838382
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12621376
122Tryptophan metabolism_Homo sapiens_hsa003800.12391527
123FoxO signaling pathway_Homo sapiens_hsa040680.12246256
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11103043
125Pathways in cancer_Homo sapiens_hsa052000.11080065
126Sulfur metabolism_Homo sapiens_hsa009200.10593714
127Tight junction_Homo sapiens_hsa045300.10463828
128Parkinsons disease_Homo sapiens_hsa050120.10377089
129Type I diabetes mellitus_Homo sapiens_hsa049400.10295161
130Melanoma_Homo sapiens_hsa052180.10072362
131Circadian rhythm_Homo sapiens_hsa047100.09318547
132Basal cell carcinoma_Homo sapiens_hsa052170.07291431
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06433350
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.05422851
135Oxidative phosphorylation_Homo sapiens_hsa001900.05302673
136T cell receptor signaling pathway_Homo sapiens_hsa046600.04947652
137Fatty acid degradation_Homo sapiens_hsa000710.04921789
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.04905458
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.03046274

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