NUDT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.10145660
2central nervous system myelination (GO:0022010)7.10145660
3protoporphyrinogen IX metabolic process (GO:0046501)6.98438137
4gas transport (GO:0015669)5.48126961
5oxygen transport (GO:0015671)5.31058613
6protoporphyrinogen IX biosynthetic process (GO:0006782)5.24233941
7fatty acid elongation (GO:0030497)5.01250228
8hemoglobin metabolic process (GO:0020027)4.95099296
9porphyrin-containing compound biosynthetic process (GO:0006779)4.91145827
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.80385308
11axon ensheathment (GO:0008366)4.72745434
12ensheathment of neurons (GO:0007272)4.72745434
13myelination (GO:0042552)4.69871992
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.61876386
15regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.54465871
16myofibril assembly (GO:0030239)4.37232510
17cilium or flagellum-dependent cell motility (GO:0001539)4.33075986
18cardiac muscle hypertrophy (GO:0003300)4.25863834
19cardiac myofibril assembly (GO:0055003)4.24829486
20negative regulation of inclusion body assembly (GO:0090084)4.21830064
21tetrapyrrole biosynthetic process (GO:0033014)4.19033551
22striated muscle hypertrophy (GO:0014897)4.14985547
23creatine metabolic process (GO:0006600)4.11845763
24axonemal dynein complex assembly (GO:0070286)4.04662863
25regulation of cardioblast differentiation (GO:0051890)4.04208971
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.99780267
27cell communication by electrical coupling (GO:0010644)3.96525298
28bundle of His cell to Purkinje myocyte communication (GO:0086069)3.94853097
29iron ion import (GO:0097286)3.90982465
30cardiac muscle contraction (GO:0060048)3.84021858
31porphyrin-containing compound metabolic process (GO:0006778)3.83631810
32sarcomere organization (GO:0045214)3.82886288
33fusion of sperm to egg plasma membrane (GO:0007342)3.79641395
34cilium movement (GO:0003341)3.76763504
35erythrocyte development (GO:0048821)3.76016730
36L-phenylalanine catabolic process (GO:0006559)3.75540874
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.75540874
38relaxation of cardiac muscle (GO:0055119)3.71161511
39asymmetric protein localization (GO:0008105)3.70932735
40erythrocyte maturation (GO:0043249)3.69120868
41myelin maintenance (GO:0043217)3.66808739
42ventricular cardiac muscle cell action potential (GO:0086005)3.66023060
43regulation of relaxation of muscle (GO:1901077)3.63307360
44regulation of actin filament-based movement (GO:1903115)3.59863301
45sperm motility (GO:0030317)3.59788135
46cell communication involved in cardiac conduction (GO:0086065)3.58108396
47muscle hypertrophy (GO:0014896)3.57866341
48negative regulation of potassium ion transmembrane transport (GO:1901380)3.56356673
49cytoskeletal anchoring at plasma membrane (GO:0007016)3.55594615
50positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.51754863
51apical protein localization (GO:0045176)3.44035088
52definitive hemopoiesis (GO:0060216)3.42429055
53epithelial cilium movement (GO:0003351)3.42399840
54cysteine metabolic process (GO:0006534)3.39609534
55L-phenylalanine metabolic process (GO:0006558)3.39417923
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.39417923
57aspartate family amino acid catabolic process (GO:0009068)3.39273269
58establishment of mitochondrion localization (GO:0051654)3.33441131
59muscle filament sliding (GO:0030049)3.32466912
60actin-myosin filament sliding (GO:0033275)3.32466912
61regulation of the force of heart contraction (GO:0002026)3.31346634
62acrosome reaction (GO:0007340)3.30900830
63cholesterol biosynthetic process (GO:0006695)3.27406554
64cardiac muscle tissue morphogenesis (GO:0055008)3.27068488
65negative regulation of neurotransmitter secretion (GO:0046929)3.26660530
66response to methylmercury (GO:0051597)3.25394261
67cardiac muscle cell development (GO:0055013)3.23320027
68long-chain fatty acid biosynthetic process (GO:0042759)3.20612754
69cardiac muscle hypertrophy in response to stress (GO:0014898)3.18482392
70muscle hypertrophy in response to stress (GO:0003299)3.18482392
71cardiac muscle adaptation (GO:0014887)3.18482392
72cellular ketone body metabolic process (GO:0046950)3.18231684
73one-carbon compound transport (GO:0019755)3.17064646
74long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.17062158
75virion attachment to host cell (GO:0019062)3.15383260
76adhesion of symbiont to host cell (GO:0044650)3.15383260
77response to mercury ion (GO:0046689)3.15143984
78fatty-acyl-CoA biosynthetic process (GO:0046949)3.14470655
79acyl-CoA biosynthetic process (GO:0071616)3.13046396
80thioester biosynthetic process (GO:0035384)3.13046396
81heme biosynthetic process (GO:0006783)3.13019209
82regulation of transforming growth factor beta2 production (GO:0032909)3.11452791
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.10124938
84desmosome organization (GO:0002934)3.09060710
85actomyosin structure organization (GO:0031032)3.08280298
86sequestering of extracellular ligand from receptor (GO:0035581)3.07162808
87regulation of cardiac muscle cell contraction (GO:0086004)3.06825646
88positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.06624166
89astrocyte development (GO:0014002)3.05071086
90negative regulation of hormone biosynthetic process (GO:0032353)3.04986645
91glycerophospholipid catabolic process (GO:0046475)3.02703817
92acetyl-CoA metabolic process (GO:0006084)3.02050346
93regulation of response to osmotic stress (GO:0047484)3.01853727
94cardiac cell development (GO:0055006)2.99231073
95amino-acid betaine transport (GO:0015838)2.98164290
96carnitine transport (GO:0015879)2.98164290
97actin-mediated cell contraction (GO:0070252)2.98018330
98sperm capacitation (GO:0048240)2.96418620
99cardiac conduction (GO:0061337)2.93382205
100negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.91990458
101striated muscle contraction (GO:0006941)2.91959037
102heme transport (GO:0015886)2.91951298
103muscle tissue morphogenesis (GO:0060415)2.91681983
104regulation of cell communication by electrical coupling (GO:0010649)2.91422797
105protein localization to endosome (GO:0036010)2.89809459
106regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.88340038
107fatty-acyl-CoA metabolic process (GO:0035337)2.87660155
108short-chain fatty acid metabolic process (GO:0046459)2.87636616
109ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.87218125
110regulation of inclusion body assembly (GO:0090083)2.85700410
111photoreceptor cell differentiation (GO:0046530)2.85130314
112eye photoreceptor cell differentiation (GO:0001754)2.85130314
113triglyceride biosynthetic process (GO:0019432)2.83555923
114sterol biosynthetic process (GO:0016126)2.83522886
115cardiac muscle cell action potential (GO:0086001)2.80607660
116long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.80359180
117acrosome assembly (GO:0001675)2.78546265
118very long-chain fatty acid metabolic process (GO:0000038)2.78407463
119plasma membrane fusion (GO:0045026)2.78342912
120adult heart development (GO:0007512)2.77922096
121carnitine transmembrane transport (GO:1902603)2.77437276
122regulation of glucocorticoid metabolic process (GO:0031943)2.77350723
123embryonic process involved in female pregnancy (GO:0060136)2.76464135
124neurotransmitter catabolic process (GO:0042135)2.76298589
125positive regulation of p38MAPK cascade (GO:1900745)2.75528237
126acylglycerol biosynthetic process (GO:0046463)2.75070118
127neutral lipid biosynthetic process (GO:0046460)2.75070118
128ketone body metabolic process (GO:1902224)2.74893469
129drug transmembrane transport (GO:0006855)2.74031087
130multicellular organism reproduction (GO:0032504)2.71729859
131import into cell (GO:0098657)2.71160615
132oligodendrocyte differentiation (GO:0048709)2.68203542
133Leydig cell differentiation (GO:0033327)2.66041932
134spermatid development (GO:0007286)2.64047049
135glyoxylate metabolic process (GO:0046487)2.63281605
136interkinetic nuclear migration (GO:0022027)2.62555730
137relaxation of muscle (GO:0090075)2.61935812
138positive regulation of gluconeogenesis (GO:0045722)2.61415870
139sodium ion export (GO:0071436)2.61378150
140quaternary ammonium group transport (GO:0015697)2.60532724
141negative regulation of hormone metabolic process (GO:0032351)2.60486947
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.59764843
143cardiac muscle cell action potential involved in contraction (GO:0086002)2.59704832
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59612309
145regulation of collateral sprouting (GO:0048670)2.57640530
146polyol transport (GO:0015791)2.56280933
147adhesion of symbiont to host (GO:0044406)2.55761236
148ventricular system development (GO:0021591)2.55581076
149peptidyl-tyrosine autophosphorylation (GO:0038083)2.54600736
150glutathione derivative biosynthetic process (GO:1901687)2.54364444
151glutathione derivative metabolic process (GO:1901685)2.54364444
152embryonic heart tube development (GO:0035050)2.54257402
153regulation of cAMP-dependent protein kinase activity (GO:2000479)2.53677768
154negative regulation of neurotransmitter transport (GO:0051589)2.52787139
155substantia nigra development (GO:0021762)2.52341226
156negative regulation of protein localization to cell surface (GO:2000009)2.52143636
157endocardial cushion development (GO:0003197)2.51958971
158regulation of steroid hormone biosynthetic process (GO:0090030)2.51930246
159acyl-CoA metabolic process (GO:0006637)2.51902818
160thioester metabolic process (GO:0035383)2.51902818
161regulation of lipoprotein metabolic process (GO:0050746)2.51761859
162response to lead ion (GO:0010288)2.51213152
163atrioventricular valve morphogenesis (GO:0003181)2.51020869
164CDP-diacylglycerol biosynthetic process (GO:0016024)2.50389822
165regulation of striated muscle contraction (GO:0006942)2.50286953
166iron coordination entity transport (GO:1901678)2.50158490
167regulation of transforming growth factor beta1 production (GO:0032908)2.47969778
168peripheral nervous system axon ensheathment (GO:0032292)2.47891695
169myelination in peripheral nervous system (GO:0022011)2.47891695
170lysine catabolic process (GO:0006554)2.47653326
171lysine metabolic process (GO:0006553)2.47653326
172negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.47516515
173organic cation transport (GO:0015695)2.47390668
174membrane tubulation (GO:0097320)2.46489666
175actin filament capping (GO:0051693)2.46293042
176aromatic amino acid family catabolic process (GO:0009074)2.45821937
177very-low-density lipoprotein particle assembly (GO:0034379)2.45790866
178positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.45593830
179axoneme assembly (GO:0035082)2.45311124
180glutathione biosynthetic process (GO:0006750)2.45272942
181carnitine shuttle (GO:0006853)2.42508434
182adrenergic receptor signaling pathway (GO:0071875)2.42284701
183sarcoplasmic reticulum calcium ion transport (GO:0070296)2.41150977
184alditol metabolic process (GO:0019400)2.40416965
185regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40194997
186negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.39968193
187fatty acid transmembrane transport (GO:1902001)2.39961889
188nonribosomal peptide biosynthetic process (GO:0019184)2.39771925
189regulation of heart rate (GO:0002027)2.39734574
190fatty acid beta-oxidation (GO:0006635)2.39634976
191regulation of cardiac muscle contraction (GO:0055117)2.39371713
192detection of calcium ion (GO:0005513)2.38408774
193myeloid cell development (GO:0061515)2.36509407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.49015499
2GATA1_19941826_ChIP-Seq_K562_Human4.19194555
3* GATA2_19941826_ChIP-Seq_K562_Human2.90159443
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.69603511
5* WT1_19549856_ChIP-ChIP_CCG9911_Human2.23562536
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18926352
7* LXR_22158963_ChIP-Seq_LIVER_Mouse2.11286251
8KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.01698619
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.00853787
10CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98296102
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.97375796
12* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89652115
13AR_21909140_ChIP-Seq_LNCAP_Human1.86248840
14VDR_22108803_ChIP-Seq_LS180_Human1.83675357
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.79542365
16SMAD3_21741376_ChIP-Seq_HESCs_Human1.67809046
17GATA2_21666600_ChIP-Seq_HMVEC_Human1.66758446
18TAF15_26573619_Chip-Seq_HEK293_Human1.65093034
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62151715
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61944756
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59993750
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.56467547
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56335454
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55303185
25* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53359298
26SCL_19346495_ChIP-Seq_HPC-7_Human1.53209096
27ER_23166858_ChIP-Seq_MCF-7_Human1.52861018
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50402437
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.50389707
30CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50038051
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43295464
32TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41692817
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39290653
34GBX2_23144817_ChIP-Seq_PC3_Human1.39094666
35* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38941685
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38248413
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.38105552
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.36999096
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34948499
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.32829109
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32229091
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.31966363
43GATA4_21415370_ChIP-Seq_HL-1_Mouse1.31733748
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30109379
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30078587
46* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29842760
47ZNF263_19887448_ChIP-Seq_K562_Human1.29341913
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27011918
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26448616
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26420799
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.25829433
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.25813625
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25477803
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25124352
55* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24921841
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24847049
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23943853
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22568423
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.22478933
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.22379753
61* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20842617
62SMAD4_21741376_ChIP-Seq_HESCs_Human1.20010612
63ZNF274_21170338_ChIP-Seq_K562_Hela1.19360468
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19288973
65FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.19280904
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16963922
67* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16609276
68* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16541032
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16044266
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15467030
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15326540
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15296070
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13585336
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12866504
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12755116
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.12599321
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.11156362
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10370831
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09986722
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09823701
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09705294
82GATA6_25053715_ChIP-Seq_YYC3_Human1.09334966
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09114777
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.08865415
85* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08497971
86* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08284301
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08246534
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07952521
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07886644
90DROSHA_22980978_ChIP-Seq_HELA_Human1.07530342
91* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07401533
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06930427
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06930427
94GATA4_25053715_ChIP-Seq_YYC3_Human1.06377796
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05845212
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05764186
97NCOR1_26117541_ChIP-Seq_K562_Human1.05665025
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04693505
99* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04648058
100TP53_16413492_ChIP-PET_HCT116_Human1.04447420
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04406253
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03898670
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.03791832
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03739610
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.03284337
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03197410
107EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03017590
108RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03017590
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02854964
110* TBL1_22424771_ChIP-Seq_293T_Human1.02548653
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02192762
112AHR_22903824_ChIP-Seq_MCF-7_Human1.02037693
113EGR1_19374776_ChIP-ChIP_THP-1_Human1.01996305
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01642882
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.01446375
116EZH2_27304074_Chip-Seq_ESCs_Mouse1.01386609
117CHD1_26751641_Chip-Seq_LNCaP_Human1.00966746
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99675056
119CLOCK_20551151_ChIP-Seq_293T_Human0.97443893
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97404908
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97402603
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97305085
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97224335
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.96136660
125* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96100433
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.95790475
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95239468
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94183529
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93917933
130EZH2_22144423_ChIP-Seq_EOC_Human0.93340411
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93240239
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91958214
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.91624919
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91543236
135JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90934549
136* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90369733
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88400313
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88115278
139* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87357592
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87272499
141* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87208080
142FOXH1_21741376_ChIP-Seq_ESCs_Human0.86669043
143STAT3_23295773_ChIP-Seq_U87_Human0.86601169
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85983421
145EOMES_21245162_ChIP-Seq_HESCs_Human0.85965334
146CBP_21632823_ChIP-Seq_H3396_Human0.85778517
147* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84813413
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.84778478
149* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84105279
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83924074
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83416015
152TBX20_22080862_ChIP-Seq_HEART_Mouse0.82997280
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.82997280
154RNF2_27304074_Chip-Seq_ESCs_Mouse0.82888574
155* FLI1_21867929_ChIP-Seq_TH2_Mouse0.82233687
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81841832
157EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81477673
158SMAD4_21799915_ChIP-Seq_A2780_Human0.81032587
159NFYB_21822215_ChIP-Seq_K562_Human0.80626874
160OCT1_27270436_Chip-Seq_PROSTATE_Human0.79742725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.28555447
2MP0000920_abnormal_myelination3.42761553
3MP0008775_abnormal_heart_ventricle2.89962601
4MP0005360_urolithiasis2.88620220
5MP0003950_abnormal_plasma_membrane2.84757180
6MP0004043_abnormal_pH_regulation2.68036899
7MP0002139_abnormal_hepatobiliary_system2.54075568
8MP0003329_amyloid_beta_deposits2.51210992
9MP0003195_calcinosis2.44134575
10MP0003690_abnormal_glial_cell2.39661828
11MP0004270_analgesia2.38599721
12MP0004885_abnormal_endolymph2.38292680
13MP0003890_abnormal_embryonic-extraembry2.36336401
14MP0002972_abnormal_cardiac_muscle2.25050290
15MP0003806_abnormal_nucleotide_metabolis2.10132095
16MP0004264_abnormal_extraembryonic_tissu2.09663630
17MP0010630_abnormal_cardiac_muscle2.09087585
18MP0004510_myositis2.06643862
19MP0005085_abnormal_gallbladder_physiolo2.05982671
20MP0001661_extended_life_span2.02469459
21MP0004147_increased_porphyrin_level1.94594936
22MP0004185_abnormal_adipocyte_glucose1.93833686
23MP0002009_preneoplasia1.87906850
24MP0005332_abnormal_amino_acid1.86647702
25MP0008875_abnormal_xenobiotic_pharmacok1.85314932
26MP0005623_abnormal_meninges_morphology1.84361459
27MP0004484_altered_response_of1.82809496
28MP0005451_abnormal_body_composition1.82772250
29MP0000747_muscle_weakness1.82408660
30MP0004085_abnormal_heartbeat1.74457258
31MP0002127_abnormal_cardiovascular_syste1.74070066
32MP0005365_abnormal_bile_salt1.71551568
33MP0004130_abnormal_muscle_cell1.64764716
34MP0002837_dystrophic_cardiac_calcinosis1.61717661
35MP0001485_abnormal_pinna_reflex1.61398407
36MP0005385_cardiovascular_system_phenoty1.60848326
37MP0001544_abnormal_cardiovascular_syste1.60848326
38MP0003634_abnormal_glial_cell1.59822183
39MP0010678_abnormal_skin_adnexa1.58408188
40MP0000751_myopathy1.57650598
41MP0004036_abnormal_muscle_relaxation1.56842207
42MP0000462_abnormal_digestive_system1.56169658
43MP0005666_abnormal_adipose_tissue1.55861829
44MP0003698_abnormal_male_reproductive1.50537171
45MP0003567_abnormal_fetal_cardiomyocyte1.49815055
46MP0004742_abnormal_vestibular_system1.48815894
47MP0004145_abnormal_muscle_electrophysio1.46318549
48MP0008057_abnormal_DNA_replication1.45532058
49MP0010368_abnormal_lymphatic_system1.41644085
50MP0003984_embryonic_growth_retardation1.39824891
51MP0002088_abnormal_embryonic_growth/wei1.39033817
52MP0003941_abnormal_skin_development1.34551903
53MP0010352_gastrointestinal_tract_polyps1.32111117
54MP0000604_amyloidosis1.30760103
55MP0003045_fibrosis1.30611893
56MP0000266_abnormal_heart_morphology1.30065085
57MP0001879_abnormal_lymphatic_vessel1.29053768
58MP0008438_abnormal_cutaneous_collagen1.28591878
59MP0000778_abnormal_nervous_system1.26809654
60MP0002118_abnormal_lipid_homeostasis1.25317586
61MP0003566_abnormal_cell_adhesion1.23007017
62MP0003828_pulmonary_edema1.21965305
63MP0001672_abnormal_embryogenesis/_devel1.19196953
64MP0005380_embryogenesis_phenotype1.19196953
65MP0000383_abnormal_hair_follicle1.15940400
66MP0001440_abnormal_grooming_behavior1.15540443
67MP0002229_neurodegeneration1.14970193
68MP0009046_muscle_twitch1.14483587
69MP0003136_yellow_coat_color1.14264772
70MP0001929_abnormal_gametogenesis1.13173035
71MP0002086_abnormal_extraembryonic_tissu1.12559353
72MP0009384_cardiac_valve_regurgitation1.11189973
73MP0003632_abnormal_nervous_system1.10764232
74MP0010234_abnormal_vibrissa_follicle1.10542759
75MP0003656_abnormal_erythrocyte_physiolo1.10209262
76MP0005369_muscle_phenotype1.08750808
77MP0003252_abnormal_bile_duct1.08203956
78MP0001486_abnormal_startle_reflex1.06775491
79MP0002925_abnormal_cardiovascular_devel1.05149594
80MP0005330_cardiomyopathy1.05081029
81MP0003880_abnormal_central_pattern1.02423622
82MP0005375_adipose_tissue_phenotype1.02086346
83MP0004272_abnormal_basement_membrane1.01312318
84MP0004019_abnormal_vitamin_homeostasis1.00359269
85MP0001784_abnormal_fluid_regulation0.99803263
86MP0001299_abnormal_eye_distance/0.99730385
87MP0000537_abnormal_urethra_morphology0.99563920
88MP0005377_hearing/vestibular/ear_phenot0.98996889
89MP0003878_abnormal_ear_physiology0.98996889
90MP0004084_abnormal_cardiac_muscle0.98652000
91MP0004087_abnormal_muscle_fiber0.98641844
92MP0005620_abnormal_muscle_contractility0.97973964
93MP0000749_muscle_degeneration0.97942127
94MP0005076_abnormal_cell_differentiation0.97686575
95MP0001765_abnormal_ion_homeostasis0.97558089
96MP0005409_darkened_coat_color0.96157878
97MP0001666_abnormal_nutrient_absorption0.95708060
98MP0002128_abnormal_blood_circulation0.95288745
99MP0002272_abnormal_nervous_system0.95078836
100MP0009840_abnormal_foam_cell0.94319475
101MP0004233_abnormal_muscle_weight0.94269323
102MP0010329_abnormal_lipoprotein_level0.92467801
103MP0002138_abnormal_hepatobiliary_system0.91917008
104MP0002734_abnormal_mechanical_nocicepti0.91910486
105MP0009643_abnormal_urine_homeostasis0.88841002
106MP0001727_abnormal_embryo_implantation0.88781204
107MP0005165_increased_susceptibility_to0.88742162
108MP0001756_abnormal_urination0.88469740
109MP0001545_abnormal_hematopoietic_system0.88331581
110MP0005397_hematopoietic_system_phenotyp0.88331581
111MP0005083_abnormal_biliary_tract0.88177570
112MP0003221_abnormal_cardiomyocyte_apopto0.88049600
113MP0001529_abnormal_vocalization0.87693214
114MP0002971_abnormal_brown_adipose0.87544143
115MP0009703_decreased_birth_body0.86023630
116MP0002269_muscular_atrophy0.85949091
117MP0005187_abnormal_penis_morphology0.85909519
118MP0000759_abnormal_skeletal_muscle0.85849328
119MP0006138_congestive_heart_failure0.85683869
120MP0002295_abnormal_pulmonary_circulatio0.85208319
121MP0003937_abnormal_limbs/digits/tail_de0.84951237
122MP0002161_abnormal_fertility/fecundity0.84399516
123MP0005167_abnormal_blood-brain_barrier0.83970235
124MP0001697_abnormal_embryo_size0.83684291
125MP0002064_seizures0.83132473
126MP0001905_abnormal_dopamine_level0.82238304
127MP0002108_abnormal_muscle_morphology0.81965638
128MP0008004_abnormal_stomach_pH0.81935596
129MP0005636_abnormal_mineral_homeostasis0.81132150
130MP0005220_abnormal_exocrine_pancreas0.81057761
131MP0002084_abnormal_developmental_patter0.80169183
132MP0001730_embryonic_growth_arrest0.79000448
133MP0003631_nervous_system_phenotype0.78766140
134MP0006036_abnormal_mitochondrial_physio0.78685192
135MP0002653_abnormal_ependyma_morphology0.78212216
136MP0002168_other_aberrant_phenotype0.76581398
137MP0003283_abnormal_digestive_organ0.76340296
138MP0004134_abnormal_chest_morphology0.75767138
139MP0004215_abnormal_myocardial_fiber0.75717945
140MP0003646_muscle_fatigue0.75616444
141MP0003137_abnormal_impulse_conducting0.75446956
142MP0002166_altered_tumor_susceptibility0.74535236
143MP0005584_abnormal_enzyme/coenzyme_acti0.74177799
144MP0003938_abnormal_ear_development0.73362111
145MP0000955_abnormal_spinal_cord0.73044855
146MP0004859_abnormal_synaptic_plasticity0.72767153
147MP0003935_abnormal_craniofacial_develop0.72318855
148MP0002066_abnormal_motor_capabilities/c0.72032927
149MP0005248_abnormal_Harderian_gland0.71779369
150MP0009780_abnormal_chondrocyte_physiolo0.71703060
151MP0003705_abnormal_hypodermis_morpholog0.71030741
152MP0002106_abnormal_muscle_physiology0.69026527
153MP0002080_prenatal_lethality0.67593749
154MP0001614_abnormal_blood_vessel0.66108747
155MP0003385_abnormal_body_wall0.62835342
156MP0005670_abnormal_white_adipose0.61692557
157MP0008961_abnormal_basal_metabolism0.59741041
158MP0000428_abnormal_craniofacial_morphol0.59587433
159MP0003943_abnormal_hepatobiliary_system0.58651412
160MP0002877_abnormal_melanocyte_morpholog0.57613052
161MP0010307_abnormal_tumor_latency0.54578242
162MP0003453_abnormal_keratinocyte_physiol0.53742293

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)6.87837671
2Abnormality of the heme biosynthetic pathway (HP:0010472)6.50047566
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.07989928
4Bundle branch block (HP:0011710)4.94286292
5Sudden death (HP:0001699)4.91951061
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.84033147
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.84033147
8Right ventricular cardiomyopathy (HP:0011663)4.68250360
9Abnormal respiratory motile cilium physiology (HP:0012261)4.67579077
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.43891222
11Absent/shortened dynein arms (HP:0200106)4.43891222
12Reticulocytosis (HP:0001923)4.42080238
13Neurofibrillary tangles (HP:0002185)4.38994584
14Acanthocytosis (HP:0001927)4.38073816
15Abnormality of the corticospinal tract (HP:0002492)3.99034563
16Abnormal ciliary motility (HP:0012262)3.92030551
17Rhinitis (HP:0012384)3.74029874
18Syncope (HP:0001279)3.68477966
19Ventricular tachycardia (HP:0004756)3.67658102
20Abnormal respiratory motile cilium morphology (HP:0005938)3.64868508
21Abnormal respiratory epithelium morphology (HP:0012253)3.64868508
22Metabolic alkalosis (HP:0200114)3.63784354
23Sensory axonal neuropathy (HP:0003390)3.60081824
24Abnormality of the calf musculature (HP:0001430)3.51799466
25Hypokalemic alkalosis (HP:0001949)3.51726928
26Cerebral inclusion bodies (HP:0100314)3.50784426
27Increased circulating renin level (HP:0000848)3.48756283
28Muscle fiber splitting (HP:0003555)3.48265074
29Diaphragmatic weakness (HP:0009113)3.39423785
30Insidious onset (HP:0003587)3.39423502
31Termporal pattern (HP:0011008)3.39423502
32Polycythemia (HP:0001901)3.24540195
33Abnormality of the left ventricular outflow tract (HP:0011103)3.21080603
34Subaortic stenosis (HP:0001682)3.21080603
35Hyporeflexia of lower limbs (HP:0002600)3.13540167
36Atrial fibrillation (HP:0005110)3.11561162
37Heart block (HP:0012722)3.10127539
38Primary atrial arrhythmia (HP:0001692)3.03950986
39Abnormal gallbladder morphology (HP:0012437)2.97643883
40Cholelithiasis (HP:0001081)2.96244228
41Abnormal atrioventricular conduction (HP:0005150)2.94019705
42Double outlet right ventricle (HP:0001719)2.93279389
43Congenital malformation of the right heart (HP:0011723)2.93279389
44Hypomagnesemia (HP:0002917)2.91293568
45Chronic bronchitis (HP:0004469)2.87682016
46Microcytic anemia (HP:0001935)2.86169656
47Papillary thyroid carcinoma (HP:0002895)2.82965994
48Supraventricular arrhythmia (HP:0005115)2.82724263
49Abnormality of glycine metabolism (HP:0010895)2.80793302
50Abnormality of serine family amino acid metabolism (HP:0010894)2.80793302
51Supraventricular tachycardia (HP:0004755)2.80131285
52Gout (HP:0001997)2.77821759
53Lipoatrophy (HP:0100578)2.72138226
54Dysmetric saccades (HP:0000641)2.65251460
55Abnormality of chloride homeostasis (HP:0011422)2.64651370
56Polyuria (HP:0000103)2.63327443
57Abnormal drinking behavior (HP:0030082)2.61465331
58Polydipsia (HP:0001959)2.61465331
59Hypochromic microcytic anemia (HP:0004840)2.61086828
60Hyperglycinuria (HP:0003108)2.60192829
61Abnormal urine output (HP:0012590)2.59709908
62Ventricular arrhythmia (HP:0004308)2.58654296
63Exercise-induced myalgia (HP:0003738)2.55774372
64Abnormal hemoglobin (HP:0011902)2.54294747
65Hyperglycinemia (HP:0002154)2.53888456
66Intention tremor (HP:0002080)2.50221669
67Spastic gait (HP:0002064)2.50088289
68Atrioventricular block (HP:0001678)2.49941203
69Paralysis (HP:0003470)2.49041989
70Ventricular fibrillation (HP:0001663)2.47959368
71Abnormality of the fingertips (HP:0001211)2.45486189
72Difficulty running (HP:0009046)2.44581512
73Abnormality of renal excretion (HP:0011036)2.41233105
74Dilated cardiomyopathy (HP:0001644)2.40061456
75Arterial tortuosity (HP:0005116)2.39061575
76Ankyloglossia (HP:0010296)2.38764523
77Intrahepatic cholestasis (HP:0001406)2.38448958
78Palpitations (HP:0001962)2.32317055
79Ileus (HP:0002595)2.28540148
80Deep venous thrombosis (HP:0002625)2.27659517
81Spastic tetraparesis (HP:0001285)2.27463178
82Hyperbilirubinemia (HP:0002904)2.26331987
83Supranuclear gaze palsy (HP:0000605)2.26012564
84Hyperlipoproteinemia (HP:0010980)2.25761249
85Peripheral hypomyelination (HP:0007182)2.24562796
86Onion bulb formation (HP:0003383)2.24485294
87Akinesia (HP:0002304)2.23945254
88Abnormality of sodium homeostasis (HP:0010931)2.23505183
89Renal salt wasting (HP:0000127)2.22582069
90Visceral angiomatosis (HP:0100761)2.21933150
91Spastic paraparesis (HP:0002313)2.21920212
92Parakeratosis (HP:0001036)2.21412812
93Prolonged QT interval (HP:0001657)2.19926148
94Abnormality of reticulocytes (HP:0004312)2.17326439
95Increased serum pyruvate (HP:0003542)2.16941341
96Abnormality of glycolysis (HP:0004366)2.16941341
97Infertility (HP:0000789)2.14944625
98Toxemia of pregnancy (HP:0100603)2.14472907
99Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13087710
100EMG: neuropathic changes (HP:0003445)2.12568107
101Hyperuricemia (HP:0002149)2.12546208
102Increased purine levels (HP:0004368)2.12546208
103EMG: myopathic abnormalities (HP:0003458)2.12182937
104Truncus arteriosus (HP:0001660)2.10960810
105Hemangiomatosis (HP:0007461)2.10726466
106Hyponatremia (HP:0002902)2.09593060
107Abnormality of magnesium homeostasis (HP:0004921)2.07830545
108Cerebral hemorrhage (HP:0001342)2.07720973
109Biliary tract neoplasm (HP:0100574)2.07186451
110Bell-shaped thorax (HP:0001591)2.05542945
111Muscle hypertrophy of the lower extremities (HP:0008968)2.05458132
112Thyroid carcinoma (HP:0002890)2.03893597
113Exercise-induced muscle cramps (HP:0003710)2.03747590
114Ketosis (HP:0001946)2.02868963
115Xanthomatosis (HP:0000991)2.01901939
116Vascular tortuosity (HP:0004948)2.01226916
117Abnormality of the gallbladder (HP:0005264)2.00876028
118Germ cell neoplasia (HP:0100728)2.00534183
119Abnormal biliary tract morphology (HP:0012440)1.98383711
120Hip contracture (HP:0003273)1.97718064
121Alkalosis (HP:0001948)1.97375994
122Overgrowth (HP:0001548)1.96486455
123Asymmetric septal hypertrophy (HP:0001670)1.95250799
124Morphological abnormality of the pyramidal tract (HP:0002062)1.92248954
125Male infertility (HP:0003251)1.91793995
126Round ear (HP:0100830)1.90645035
127Abnormality of fatty-acid metabolism (HP:0004359)1.89975367
128Hyperactive renin-angiotensin system (HP:0000841)1.89372524
129Hyperaldosteronism (HP:0000859)1.88683288
130Testicular neoplasm (HP:0010788)1.87811070
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.87476446
132Hyperglycemia (HP:0003074)1.86351656
133Abnormal gallbladder physiology (HP:0012438)1.85885756
134Cholecystitis (HP:0001082)1.85885756
135Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85602133
136Hypoglycemic seizures (HP:0002173)1.85535132
137Pheochromocytoma (HP:0002666)1.85183445
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84807684
139Coronal craniosynostosis (HP:0004440)1.83151068
140Transposition of the great arteries (HP:0001669)1.81148123
141Abnormal connection of the cardiac segments (HP:0011545)1.81148123
142Abnormal ventriculo-arterial connection (HP:0011563)1.81148123
143Dysmetria (HP:0001310)1.80683037
144Lower limb muscle weakness (HP:0007340)1.80051944
145Abnormal auditory evoked potentials (HP:0006958)1.78688020
146Stridor (HP:0010307)1.78686091
147Neoplasm of the small intestine (HP:0100833)1.78427376
148Gowers sign (HP:0003391)1.77201907
149Macroorchidism (HP:0000053)1.75787220
150Nemaline bodies (HP:0003798)1.74941727
151Decreased circulating renin level (HP:0003351)1.74029141
152Urinary urgency (HP:0000012)1.73593770
153Autoamputation (HP:0001218)1.72794900
154Tetraparesis (HP:0002273)1.72588508
155Osteomalacia (HP:0002749)1.71517588
156Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71348933
157Abnormal pancreas size (HP:0012094)1.71334379
158Muscle fiber inclusion bodies (HP:0100299)1.70724749
159Adrenal overactivity (HP:0002717)1.70328395
160Acute myeloid leukemia (HP:0004808)1.70078443
161Abnormality of renin-angiotensin system (HP:0000847)1.69325863
162Back pain (HP:0003418)1.69320893
163Tubulointerstitial fibrosis (HP:0005576)1.66512792
164Gastrointestinal carcinoma (HP:0002672)1.66372808
165Malignant gastrointestinal tract tumors (HP:0006749)1.66372808
166Limited hip movement (HP:0008800)1.65629005
167Abnormality of potassium homeostasis (HP:0011042)1.65252270
168Hypoglycemic coma (HP:0001325)1.64835987
169Hypokalemia (HP:0002900)1.63078742
170Skin pits (HP:0100276)1.61598517
171Megalencephaly (HP:0001355)1.60891585
172Anteriorly placed anus (HP:0001545)1.60801107
173Curly hair (HP:0002212)1.60308931
174Abnormal EKG (HP:0003115)1.60175114
175Hyperammonemia (HP:0001987)1.59521527
176Ankle clonus (HP:0011448)1.59477183
177Increased variability in muscle fiber diameter (HP:0003557)1.59090449
178Hyperkalemia (HP:0002153)1.56256503
179Myoglobinuria (HP:0002913)1.55994969
180Infantile muscular hypotonia (HP:0008947)1.54486993
181Calf muscle hypertrophy (HP:0008981)1.54360594
182Premature rupture of membranes (HP:0001788)1.54184979
183Leukodystrophy (HP:0002415)1.54174474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.13999789
2OXSR14.84341141
3EIF2AK14.65632992
4WNK44.17799629
5PDK43.39973345
6PDK33.39973345
7AKT32.94156221
8PKN22.92121934
9PNCK2.91910231
10ICK2.86628486
11PDK22.53262649
12EPHB12.29164629
13WNK12.25730578
14MET2.23272400
15EEF2K2.08642709
16FGFR22.01199867
17SGK21.96582445
18STK38L1.87699552
19WNK31.84410074
20BRSK21.79704620
21PRPF4B1.79034574
22TIE11.77085978
23STK41.75096761
24SGK31.73122145
25MARK11.72816782
26PAK61.65664207
27BCR1.63630982
28CDK191.60650012
29PKN11.56644737
30STK241.55597581
31MYLK1.53485437
32PHKG11.43929934
33PHKG21.43929934
34NTRK31.40317726
35SCYL21.35565373
36PAK31.33147407
37FGFR31.28214290
38LIMK11.26330722
39PRKD31.22748753
40NTRK11.18021671
41CSNK1A1L1.14950855
42CSNK1G31.14244503
43CAMK1D1.10723998
44TYRO31.10654731
45MAPK151.07433073
46BRD41.06508586
47CDK121.06385525
48CSNK1G11.04622980
49MKNK21.04215104
50CSNK1G21.03028771
51FLT30.99270913
52MAP3K90.97638367
53PDPK10.97514792
54BMX0.97177836
55MAP2K10.95991559
56ROCK20.95623988
57NEK90.92493907
58BCKDK0.92117353
59MAP3K100.91716828
60LATS10.91627329
61NEK60.90626537
62NLK0.89824902
63KSR10.88777723
64MAP3K70.87481387
65SGK10.87162540
66CAMK1G0.86040123
67PTK2B0.85924328
68KSR20.85848532
69ACVR1B0.85476444
70PIK3CA0.84993401
71EIF2AK30.84773621
72RET0.84727809
73DDR20.84281032
74TESK20.83722880
75MAPK120.80796342
76TTN0.79951662
77LATS20.79302827
78CAMK2D0.77458537
79MST40.76916691
80TESK10.76877458
81CLK10.75516303
82ERBB40.74822689
83STK110.74327734
84PBK0.73401181
85OBSCN0.72798349
86HIPK20.71603470
87SGK2230.71415368
88SGK4940.71415368
89MST1R0.71123088
90CAMK2B0.69930169
91GSK3A0.69421650
92CDK140.68882038
93CAMK2G0.68739746
94FER0.68489353
95DMPK0.68022916
96EPHB20.67888824
97STK380.67376597
98PINK10.66211331
99DYRK20.66046554
100PDK10.65772144
101CAMK40.64740329
102FGR0.62610694
103BMPR1B0.60697567
104MAP2K20.60223605
105UHMK10.60097160
106TTK0.58528316
107CDK150.58477427
108MAP3K10.58227233
109TRIB30.58066771
110STK30.57543387
111CDK50.56052605
112PAK20.55590828
113MAPKAPK50.55378500
114EPHA40.55270723
115RIPK10.54594286
116EPHA20.54140696
117PLK20.53257326
118PIM10.51911917
119PRKAA10.51326533
120MAPK100.51075838
121CDK180.49503757
122PRKD10.49464305
123BMPR20.48991858
124ARAF0.48987188
125PDGFRA0.48250893
126CDK11A0.47899714
127YES10.46959208
128AKT20.44930072
129CSNK1D0.44578331
130LMTK20.44389259
131CAMK2A0.43055512
132MAP3K130.41775771
133RPS6KB20.41520737
134MAP3K20.41099982
135RAF10.40539352
136PRKCQ0.39694696
137MAP3K40.39670332
138MAPKAPK30.38646953
139TNIK0.37964934
140PRKACB0.37140566
141ERBB20.34007586
142CAMK10.33878572
143ERBB30.33455940
144PDGFRB0.33047591
145FGFR40.33014032
146MELK0.32767899
147MARK20.32541697
148MAP2K40.32294059
149PAK10.32054469
150PLK30.31713951
151PRKAA20.31359364
152FRK0.31300316
153PTK20.31189487
154ROCK10.30932461
155RPS6KA30.30215791
156TRPM70.28884427
157CSNK1E0.28598989
158ABL20.28138769
159PRKG10.27305614
160PRKCE0.26502055
161MTOR0.25743361
162FYN0.25569774

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64779204
2Vitamin B6 metabolism_Homo sapiens_hsa007503.28965495
3Propanoate metabolism_Homo sapiens_hsa006402.84746652
4Butanoate metabolism_Homo sapiens_hsa006502.80748432
5Fatty acid elongation_Homo sapiens_hsa000622.76413350
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.67624714
7Steroid biosynthesis_Homo sapiens_hsa001002.56526195
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37257235
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35273719
10Dilated cardiomyopathy_Homo sapiens_hsa054142.30679792
11Nitrogen metabolism_Homo sapiens_hsa009102.23399542
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21521417
13Sulfur metabolism_Homo sapiens_hsa009202.19434334
14Fatty acid metabolism_Homo sapiens_hsa012122.13934624
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13564178
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01366031
17Circadian rhythm_Homo sapiens_hsa047101.94365598
18Fatty acid degradation_Homo sapiens_hsa000711.91238035
19Pyruvate metabolism_Homo sapiens_hsa006201.87638404
20PPAR signaling pathway_Homo sapiens_hsa033201.74363923
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63301830
22Fatty acid biosynthesis_Homo sapiens_hsa000611.60432312
23Ether lipid metabolism_Homo sapiens_hsa005651.53878176
24Endometrial cancer_Homo sapiens_hsa052131.47059388
25Adherens junction_Homo sapiens_hsa045201.43745284
26mTOR signaling pathway_Homo sapiens_hsa041501.43639946
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.38858136
28Histidine metabolism_Homo sapiens_hsa003401.36844772
29Peroxisome_Homo sapiens_hsa041461.36345561
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36315321
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.35665660
32Insulin resistance_Homo sapiens_hsa049311.34735485
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32820831
34Insulin signaling pathway_Homo sapiens_hsa049101.31890604
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30074026
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.29145774
37Long-term potentiation_Homo sapiens_hsa047201.27835603
38Chronic myeloid leukemia_Homo sapiens_hsa052201.25188572
39Arginine and proline metabolism_Homo sapiens_hsa003301.21454521
40TGF-beta signaling pathway_Homo sapiens_hsa043501.21199908
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20864580
42Bile secretion_Homo sapiens_hsa049761.18309585
43Tryptophan metabolism_Homo sapiens_hsa003801.18045990
44Insulin secretion_Homo sapiens_hsa049111.17742537
45Inositol phosphate metabolism_Homo sapiens_hsa005621.17277590
46Glutathione metabolism_Homo sapiens_hsa004801.17056988
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16880179
48Pancreatic cancer_Homo sapiens_hsa052121.15379863
49FoxO signaling pathway_Homo sapiens_hsa040681.14191829
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13815399
51Carbon metabolism_Homo sapiens_hsa012001.13756314
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11683528
53Arginine biosynthesis_Homo sapiens_hsa002201.11151967
54Glycerolipid metabolism_Homo sapiens_hsa005611.10547657
55Non-small cell lung cancer_Homo sapiens_hsa052231.09654601
56Prostate cancer_Homo sapiens_hsa052151.08002503
57Linoleic acid metabolism_Homo sapiens_hsa005911.07359716
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05841307
59Glioma_Homo sapiens_hsa052141.05563112
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05300285
61Type II diabetes mellitus_Homo sapiens_hsa049301.05081971
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04324933
63Thyroid cancer_Homo sapiens_hsa052161.04307839
64Focal adhesion_Homo sapiens_hsa045101.03166634
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01446975
66Dorso-ventral axis formation_Homo sapiens_hsa043201.00976354
67beta-Alanine metabolism_Homo sapiens_hsa004100.99486954
68HIF-1 signaling pathway_Homo sapiens_hsa040660.98141994
69Small cell lung cancer_Homo sapiens_hsa052220.97615300
70Fat digestion and absorption_Homo sapiens_hsa049750.97051700
71Tight junction_Homo sapiens_hsa045300.96129350
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.95683107
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95427609
74Cardiac muscle contraction_Homo sapiens_hsa042600.94313723
75Renin secretion_Homo sapiens_hsa049240.92581744
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92468653
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.90494031
78Axon guidance_Homo sapiens_hsa043600.90355894
79Renal cell carcinoma_Homo sapiens_hsa052110.90186409
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.89204629
81MicroRNAs in cancer_Homo sapiens_hsa052060.88738007
82Choline metabolism in cancer_Homo sapiens_hsa052310.88644202
83Oxidative phosphorylation_Homo sapiens_hsa001900.88395560
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.87494615
85Amphetamine addiction_Homo sapiens_hsa050310.86910296
86Chemical carcinogenesis_Homo sapiens_hsa052040.85886846
87ErbB signaling pathway_Homo sapiens_hsa040120.85815464
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84662320
89Mineral absorption_Homo sapiens_hsa049780.81229894
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.80793683
91Melanoma_Homo sapiens_hsa052180.80543306
92Thyroid hormone synthesis_Homo sapiens_hsa049180.79582658
93Vitamin digestion and absorption_Homo sapiens_hsa049770.79229604
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79023969
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75948814
96Calcium signaling pathway_Homo sapiens_hsa040200.75729616
97Retinol metabolism_Homo sapiens_hsa008300.74982333
98Prolactin signaling pathway_Homo sapiens_hsa049170.73993663
99cAMP signaling pathway_Homo sapiens_hsa040240.73563801
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72676093
101Proteoglycans in cancer_Homo sapiens_hsa052050.71734031
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71700455
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69514997
104Lysine degradation_Homo sapiens_hsa003100.68628426
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67595884
106Sphingolipid metabolism_Homo sapiens_hsa006000.67434231
107GnRH signaling pathway_Homo sapiens_hsa049120.66718611
108Oxytocin signaling pathway_Homo sapiens_hsa049210.66306151
109VEGF signaling pathway_Homo sapiens_hsa043700.66248605
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63620654
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63097238
112Parkinsons disease_Homo sapiens_hsa050120.62606272
113Biosynthesis of amino acids_Homo sapiens_hsa012300.62520525
114Oocyte meiosis_Homo sapiens_hsa041140.61959536
115Alzheimers disease_Homo sapiens_hsa050100.61939683
116AMPK signaling pathway_Homo sapiens_hsa041520.61525184
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61200663
118Complement and coagulation cascades_Homo sapiens_hsa046100.60836245
119Bladder cancer_Homo sapiens_hsa052190.55642793
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55443094
121Protein digestion and absorption_Homo sapiens_hsa049740.55380480
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.55303936
123Huntingtons disease_Homo sapiens_hsa050160.54406317
124Melanogenesis_Homo sapiens_hsa049160.52693662
125Tyrosine metabolism_Homo sapiens_hsa003500.51976944
126Estrogen signaling pathway_Homo sapiens_hsa049150.51597759
127Amoebiasis_Homo sapiens_hsa051460.51101780
128Metabolic pathways_Homo sapiens_hsa011000.51080904
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48856848
130Pentose phosphate pathway_Homo sapiens_hsa000300.48061018
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47265050
132ECM-receptor interaction_Homo sapiens_hsa045120.45974775
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.45107761
134Phenylalanine metabolism_Homo sapiens_hsa003600.44669847
135Starch and sucrose metabolism_Homo sapiens_hsa005000.43511502
136Gastric acid secretion_Homo sapiens_hsa049710.41671535
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41415463
138Hedgehog signaling pathway_Homo sapiens_hsa043400.39517067
139Endocytosis_Homo sapiens_hsa041440.38857224
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.38448127
141Collecting duct acid secretion_Homo sapiens_hsa049660.37545446
142Folate biosynthesis_Homo sapiens_hsa007900.37054410
143Regulation of autophagy_Homo sapiens_hsa041400.36726023
144ABC transporters_Homo sapiens_hsa020100.36674378
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36265437
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36070908
147Selenocompound metabolism_Homo sapiens_hsa004500.35351593
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34197037
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33928180
150Ovarian steroidogenesis_Homo sapiens_hsa049130.33668878
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31890261
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29764687
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29551558
154Pancreatic secretion_Homo sapiens_hsa049720.28869425
155Hippo signaling pathway_Homo sapiens_hsa043900.28112323
156Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28048821
157Glucagon signaling pathway_Homo sapiens_hsa049220.27428333

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