NUDT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.03893723
2ATP synthesis coupled proton transport (GO:0015986)7.66291290
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.66291290
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.31100872
5chaperone-mediated protein transport (GO:0072321)6.23393425
6ribosomal small subunit biogenesis (GO:0042274)6.05980587
7respiratory electron transport chain (GO:0022904)5.89431704
8electron transport chain (GO:0022900)5.76335420
9viral transcription (GO:0019083)5.43842113
10ribosomal small subunit assembly (GO:0000028)5.36724595
11translational termination (GO:0006415)5.28502288
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.11337697
13NADH dehydrogenase complex assembly (GO:0010257)5.11337697
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.11337697
15proteasome assembly (GO:0043248)4.97690852
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.94063686
17protein complex biogenesis (GO:0070271)4.91380740
18GTP biosynthetic process (GO:0006183)4.79584657
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.77904684
20cotranslational protein targeting to membrane (GO:0006613)4.77254952
21protein targeting to ER (GO:0045047)4.69957308
22protein neddylation (GO:0045116)4.64596283
23translational elongation (GO:0006414)4.60394008
24cullin deneddylation (GO:0010388)4.60263676
25protein localization to endoplasmic reticulum (GO:0070972)4.51264315
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.46673147
27mitochondrial respiratory chain complex assembly (GO:0033108)4.44548884
28oxidative phosphorylation (GO:0006119)4.43339652
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39970759
30maturation of SSU-rRNA (GO:0030490)4.32083002
31regulation of cellular amino acid metabolic process (GO:0006521)4.29687534
32cellular protein complex disassembly (GO:0043624)4.27430528
33protein deneddylation (GO:0000338)4.22201415
34viral life cycle (GO:0019058)4.21678623
35UTP biosynthetic process (GO:0006228)4.16610070
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.13510017
37termination of RNA polymerase III transcription (GO:0006386)4.12205501
38transcription elongation from RNA polymerase III promoter (GO:0006385)4.12205501
39translational initiation (GO:0006413)4.11582469
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.10321712
41guanosine-containing compound biosynthetic process (GO:1901070)4.10194077
42purine nucleoside triphosphate biosynthetic process (GO:0009145)4.07767937
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.05939701
44negative regulation of ligase activity (GO:0051352)4.05939701
45translation (GO:0006412)4.04775030
467-methylguanosine mRNA capping (GO:0006370)4.01046844
47sequestering of actin monomers (GO:0042989)3.97230315
48protein targeting to mitochondrion (GO:0006626)3.95453190
497-methylguanosine RNA capping (GO:0009452)3.95092604
50RNA capping (GO:0036260)3.95092604
51ATP biosynthetic process (GO:0006754)3.94631548
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.89857065
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.89298876
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.88656572
55establishment of protein localization to mitochondrion (GO:0072655)3.88398142
56regulation of mitochondrial translation (GO:0070129)3.87877521
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.84776184
58L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.81981330
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.80848405
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.80848405
61ribosomal large subunit biogenesis (GO:0042273)3.79031026
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.77978317
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75694397
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75694397
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75694397
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70063169
67ribonucleoside triphosphate biosynthetic process (GO:0009201)3.69164081
68UTP metabolic process (GO:0046051)3.66776745
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.63491560
70signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63491560
71respiratory chain complex IV assembly (GO:0008535)3.62312585
72cellular component biogenesis (GO:0044085)3.61217645
73protein localization to mitochondrion (GO:0070585)3.59961406
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.59480162
75hydrogen ion transmembrane transport (GO:1902600)3.52516420
76protein complex disassembly (GO:0043241)3.52360664
77organelle disassembly (GO:1903008)3.50823477
78CTP biosynthetic process (GO:0006241)3.47088264
79CTP metabolic process (GO:0046036)3.47088264
80base-excision repair, AP site formation (GO:0006285)3.46363025
81antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.46203373
82regulation of cellular amine metabolic process (GO:0033238)3.44323753
83macromolecular complex disassembly (GO:0032984)3.41262523
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41242989
85inner mitochondrial membrane organization (GO:0007007)3.41170742
86ribonucleoprotein complex biogenesis (GO:0022613)3.41100762
87nucleoside triphosphate biosynthetic process (GO:0009142)3.36563210
88nucleoside diphosphate phosphorylation (GO:0006165)3.35342507
89establishment of integrated proviral latency (GO:0075713)3.33011637
90nuclear-transcribed mRNA catabolic process (GO:0000956)3.30857157
91positive regulation of ligase activity (GO:0051351)3.29585572
92water-soluble vitamin biosynthetic process (GO:0042364)3.27409687
93cytochrome complex assembly (GO:0017004)3.26514511
94ubiquinone biosynthetic process (GO:0006744)3.25666618
95termination of RNA polymerase I transcription (GO:0006363)3.22984340
96L-methionine salvage (GO:0071267)3.21744334
97L-methionine biosynthetic process (GO:0071265)3.21744334
98amino acid salvage (GO:0043102)3.21744334
99peptidyl-histidine modification (GO:0018202)3.21086368
100formation of translation preinitiation complex (GO:0001731)3.20825640
101pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.20603426
102mitochondrial transport (GO:0006839)3.19625263
103proton transport (GO:0015992)3.18574720
104transcription elongation from RNA polymerase I promoter (GO:0006362)3.16843308
105mRNA catabolic process (GO:0006402)3.16835809
106protein targeting to membrane (GO:0006612)3.14485975
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13314472
108pyrimidine nucleotide catabolic process (GO:0006244)3.13080892
109intracellular protein transmembrane import (GO:0044743)3.12530863
110hydrogen transport (GO:0006818)3.12403018
111regulation of cilium movement (GO:0003352)3.08344765
112ribonucleoprotein complex disassembly (GO:0032988)3.02955695
113ubiquinone metabolic process (GO:0006743)3.02348176
114pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.00348075
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99563928
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99108255
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97023367
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97023367
119epithelial cilium movement (GO:0003351)2.91922975
120RNA catabolic process (GO:0006401)2.87356196
121protein targeting (GO:0006605)2.84402961
122CENP-A containing nucleosome assembly (GO:0034080)2.82337811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.75364107
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.29212245
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.65181621
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.18209308
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.14070288
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.07051245
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.82452679
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.72695952
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.66390631
10* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.50121859
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37954426
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.34677331
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24417165
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.22094782
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20928382
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86629778
17* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.55920410
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.46833316
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44534633
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43198223
21VDR_23849224_ChIP-Seq_CD4+_Human2.39541857
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36000423
23DCP1A_22483619_ChIP-Seq_HELA_Human2.31423881
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23231020
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22469684
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22445837
27ELK1_19687146_ChIP-ChIP_HELA_Human2.20666873
28XRN2_22483619_ChIP-Seq_HELA_Human2.09022590
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.07268946
30* TTF2_22483619_ChIP-Seq_HELA_Human1.90872742
31* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85845221
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84323146
33* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78798650
34FOXP3_21729870_ChIP-Seq_TREG_Human1.77558556
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74466223
36GABP_19822575_ChIP-Seq_HepG2_Human1.71910515
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.69944293
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68072341
39E2F7_22180533_ChIP-Seq_HELA_Human1.63527005
40ZNF274_21170338_ChIP-Seq_K562_Hela1.51836716
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49812829
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47248045
43IRF1_19129219_ChIP-ChIP_H3396_Human1.43027251
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42587283
45FUS_26573619_Chip-Seq_HEK293_Human1.42262346
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39003519
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38331754
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38082955
49MYC_18940864_ChIP-ChIP_HL60_Human1.37562958
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30486233
51VDR_22108803_ChIP-Seq_LS180_Human1.30129141
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24090043
53ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19113045
54* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15351858
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.13269854
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11080011
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10679294
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09269239
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08466303
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05893677
61* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04302233
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04226008
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04181024
64KDM5A_27292631_Chip-Seq_BREAST_Human1.03740006
65* SOX17_20123909_ChIP-Seq_XEN_Mouse1.02176216
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01963119
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01770885
68TP53_22573176_ChIP-Seq_HFKS_Human1.01687235
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00238234
70PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99203652
71BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98419832
72NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97607327
73NANOG_16153702_ChIP-ChIP_HESCs_Human0.97287898
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96297870
75TAF15_26573619_Chip-Seq_HEK293_Human0.95892299
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94793315
77EWS_26573619_Chip-Seq_HEK293_Human0.93822855
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92941176
79FOXM1_23109430_ChIP-Seq_U2OS_Human0.92779349
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92226310
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90601413
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88887618
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87745352
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86834114
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84329124
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82624564
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81474545
88E2F1_21310950_ChIP-Seq_MCF-7_Human0.81372986
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80279656
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79806535
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79611477
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77891430
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.76627813
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76387345
95* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76301804
96RNF2_27304074_Chip-Seq_NSC_Mouse0.76237499
97HTT_18923047_ChIP-ChIP_STHdh_Human0.74082135
98AR_20517297_ChIP-Seq_VCAP_Human0.73625295
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73227557
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73100999
101LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72918948
102REST_19997604_ChIP-ChIP_NEURONS_Mouse0.71991304
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.70846716
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69764445
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.69331386
106* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68499800
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.68379251
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.68064018
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67474761
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.65930881
111ER_23166858_ChIP-Seq_MCF-7_Human0.65728150
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.65422079
113CBX2_27304074_Chip-Seq_ESCs_Mouse0.65134373
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64730585
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.63324532
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.63256496
117ELF5_23300383_ChIP-Seq_T47D_Human0.63124346
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.61625377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.60226526
2MP0009379_abnormal_foot_pigmentation4.29658734
3MP0001529_abnormal_vocalization3.90521538
4MP0001905_abnormal_dopamine_level3.47619751
5MP0006276_abnormal_autonomic_nervous2.86805175
6MP0003011_delayed_dark_adaptation2.79843416
7MP0003806_abnormal_nucleotide_metabolis2.79331496
8MP0000566_synostosis2.65977052
9MP0006036_abnormal_mitochondrial_physio2.48996621
10MP0003186_abnormal_redox_activity2.33965307
11MP0005451_abnormal_body_composition2.28846509
12MP0002837_dystrophic_cardiac_calcinosis2.27800923
13MP0006035_abnormal_mitochondrial_morpho2.27475070
14MP0002938_white_spotting2.16011076
15MP0003718_maternal_effect2.13347509
16MP0003646_muscle_fatigue2.10602153
17MP0006292_abnormal_olfactory_placode2.07307233
18MP0002638_abnormal_pupillary_reflex2.05085785
19MP0002735_abnormal_chemical_nociception1.87821227
20MP0003693_abnormal_embryo_hatching1.80880330
21MP0006072_abnormal_retinal_apoptosis1.80488205
22MP0001293_anophthalmia1.72452818
23MP0008789_abnormal_olfactory_epithelium1.72091571
24MP0009697_abnormal_copulation1.71516988
25MP0004957_abnormal_blastocyst_morpholog1.70999622
26MP0005084_abnormal_gallbladder_morpholo1.63832299
27MP0002653_abnormal_ependyma_morphology1.59722832
28MP0008932_abnormal_embryonic_tissue1.59716846
29MP0005408_hypopigmentation1.56856965
30MP0000372_irregular_coat_pigmentation1.50396925
31MP0003938_abnormal_ear_development1.50016170
32MP0000749_muscle_degeneration1.49465435
33MP0002102_abnormal_ear_morphology1.49411727
34MP0005253_abnormal_eye_physiology1.49255786
35MP0002736_abnormal_nociception_after1.47837393
36MP0001984_abnormal_olfaction1.47697206
37MP0004142_abnormal_muscle_tone1.47671794
38MP0001440_abnormal_grooming_behavior1.46390405
39MP0000751_myopathy1.44092846
40MP0003121_genomic_imprinting1.41456921
41MP0002734_abnormal_mechanical_nocicepti1.38723413
42MP0005551_abnormal_eye_electrophysiolog1.37976851
43MP0003787_abnormal_imprinting1.33764705
44MP0001968_abnormal_touch/_nociception1.33167820
45MP0008260_abnormal_autophagy1.28750307
46MP0010030_abnormal_orbit_morphology1.28099425
47MP0003077_abnormal_cell_cycle1.27460138
48MP0002272_abnormal_nervous_system1.26074691
49MP0005379_endocrine/exocrine_gland_phen1.22878413
50MP0003786_premature_aging1.22287442
51MP0000778_abnormal_nervous_system1.22247539
52MP0004215_abnormal_myocardial_fiber1.22170893
53MP0004145_abnormal_muscle_electrophysio1.21517783
54MP0002572_abnormal_emotion/affect_behav1.21063785
55MP0002064_seizures1.20944210
56MP0009745_abnormal_behavioral_response1.20854615
57MP0002095_abnormal_skin_pigmentation1.19944829
58MP0002210_abnormal_sex_determination1.19077798
59MP0005646_abnormal_pituitary_gland1.18421548
60MP0003123_paternal_imprinting1.17776504
61MP0001727_abnormal_embryo_implantation1.14822207
62MP0005423_abnormal_somatic_nervous1.13901126
63MP0002090_abnormal_vision1.12773963
64MP0005391_vision/eye_phenotype1.11671394
65MP0008995_early_reproductive_senescence1.11541339
66MP0002282_abnormal_trachea_morphology1.10825048
67MP0005499_abnormal_olfactory_system1.10140202
68MP0005394_taste/olfaction_phenotype1.10140202
69MP0000049_abnormal_middle_ear1.09922619
70MP0002876_abnormal_thyroid_physiology1.09092683
71MP0010386_abnormal_urinary_bladder1.08702216
72MP0001970_abnormal_pain_threshold1.07387163
73MP0000647_abnormal_sebaceous_gland1.07050062
74MP0002751_abnormal_autonomic_nervous1.06857442
75MP0003315_abnormal_perineum_morphology1.06467115
76MP0004133_heterotaxia1.06143988
77MP0001485_abnormal_pinna_reflex1.06003436
78MP0000569_abnormal_digit_pigmentation1.05509986
79MP0001929_abnormal_gametogenesis1.05255995
80MP0003122_maternal_imprinting1.04685251
81MP0005174_abnormal_tail_pigmentation1.04252709
82MP0004270_analgesia1.04201924
83MP0004036_abnormal_muscle_relaxation1.02765207
84MP0008877_abnormal_DNA_methylation1.01688930
85MP0004742_abnormal_vestibular_system1.01534228
86MP0002160_abnormal_reproductive_system1.01043669
87MP0004885_abnormal_endolymph0.99092587
88MP0008007_abnormal_cellular_replicative0.98265320
89MP0002063_abnormal_learning/memory/cond0.97665234
90MP0002233_abnormal_nose_morphology0.97455455
91MP0003329_amyloid_beta_deposits0.97227604
92MP0005171_absent_coat_pigmentation0.96068047
93MP0004147_increased_porphyrin_level0.94792398
94MP0005195_abnormal_posterior_eye0.94647368
95MP0005330_cardiomyopathy0.94249005
96MP0003137_abnormal_impulse_conducting0.93785425
97MP0001764_abnormal_homeostasis0.92957293
98MP0002184_abnormal_innervation0.92502415
99MP0005645_abnormal_hypothalamus_physiol0.92293802
100MP0001501_abnormal_sleep_pattern0.91648834
101MP0000427_abnormal_hair_cycle0.91134873
102MP0005187_abnormal_penis_morphology0.90897838
103MP0000026_abnormal_inner_ear0.90210879
104MP0003635_abnormal_synaptic_transmissio0.89795640
105MP0004084_abnormal_cardiac_muscle0.89505804
106MP0009046_muscle_twitch0.88185292
107MP0001542_abnormal_bone_strength0.87389845
108MP0008058_abnormal_DNA_repair0.86946552
109MP0000343_altered_response_to0.86944864
110MP0002733_abnormal_thermal_nociception0.85292402
111MP0008875_abnormal_xenobiotic_pharmacok0.85182113
112MP0001324_abnormal_eye_pigmentation0.84655287
113MP0002277_abnormal_respiratory_mucosa0.83238106
114MP0001145_abnormal_male_reproductive0.82366035
115MP0000653_abnormal_sex_gland0.82015247
116MP0009250_abnormal_appendicular_skeleto0.80873724
117MP0001286_abnormal_eye_development0.80456900
118MP0004924_abnormal_behavior0.80184538
119MP0005386_behavior/neurological_phenoty0.80184538
120MP0002909_abnormal_adrenal_gland0.79348878
121MP0003136_yellow_coat_color0.77798740
122MP0002295_abnormal_pulmonary_circulatio0.77309336
123MP0005636_abnormal_mineral_homeostasis0.76779213
124MP0010094_abnormal_chromosome_stability0.75482437
125MP0002067_abnormal_sensory_capabilities0.73721514
126MP0000358_abnormal_cell_content/0.73161259
127MP0005389_reproductive_system_phenotype0.71400591
128MP0000750_abnormal_muscle_regeneration0.71341280
129MP0003221_abnormal_cardiomyocyte_apopto0.70300769
130MP0000631_abnormal_neuroendocrine_gland0.69929709
131MP0002752_abnormal_somatic_nervous0.69663526
132MP0002066_abnormal_motor_capabilities/c0.68630910
133MP0008872_abnormal_physiological_respon0.65964204
134MP0005332_abnormal_amino_acid0.65045581
135MP0002163_abnormal_gland_morphology0.63857542
136MP0001486_abnormal_startle_reflex0.63219359
137MP0000920_abnormal_myelination0.62609821
138MP0002557_abnormal_social/conspecific_i0.62111778
139MP0005266_abnormal_metabolism0.61788525
140MP0003634_abnormal_glial_cell0.60531700
141MP0003195_calcinosis0.60366245

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.08604602
2Abnormal mitochondria in muscle tissue (HP:0008316)6.38536606
3Mitochondrial inheritance (HP:0001427)6.00178915
4Progressive macrocephaly (HP:0004481)5.83214795
5Acute encephalopathy (HP:0006846)5.78654471
6Increased CSF lactate (HP:0002490)5.34795898
7Increased hepatocellular lipid droplets (HP:0006565)5.06083122
8Hepatocellular necrosis (HP:0001404)4.92467108
9Increased serum pyruvate (HP:0003542)4.91175810
10Abnormality of glycolysis (HP:0004366)4.91175810
11Abnormality of cells of the erythroid lineage (HP:0012130)4.68188135
12Lipid accumulation in hepatocytes (HP:0006561)4.48582253
13Hepatic necrosis (HP:0002605)4.32426083
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.31717664
15Renal Fanconi syndrome (HP:0001994)4.24425848
16Cerebral edema (HP:0002181)4.14663910
17Abnormal number of erythroid precursors (HP:0012131)3.96071995
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.93964235
19Exercise intolerance (HP:0003546)3.84825123
203-Methylglutaconic aciduria (HP:0003535)3.76947265
21Increased intramyocellular lipid droplets (HP:0012240)3.75920819
22Increased serum lactate (HP:0002151)3.64064268
23Respiratory failure (HP:0002878)3.60674769
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.59482726
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.59482726
26Optic disc pallor (HP:0000543)3.56640801
27Leukodystrophy (HP:0002415)3.53832445
28Lactic acidosis (HP:0003128)3.52606417
29Reticulocytopenia (HP:0001896)3.21141509
30Exertional dyspnea (HP:0002875)3.16025125
31Increased muscle lipid content (HP:0009058)3.10851875
32Macrocytic anemia (HP:0001972)3.01300566
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.99570877
34Respiratory difficulties (HP:0002880)2.98417921
35Parakeratosis (HP:0001036)2.96628111
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74050784
37Abnormal respiratory epithelium morphology (HP:0012253)2.67450791
38Abnormal respiratory motile cilium morphology (HP:0005938)2.67450791
39Abnormality of renal resorption (HP:0011038)2.62824022
40Cerebral hypomyelination (HP:0006808)2.56987149
41CNS demyelination (HP:0007305)2.53077064
42Abnormality of midbrain morphology (HP:0002418)2.51010429
43Molar tooth sign on MRI (HP:0002419)2.51010429
44Hyperglycinemia (HP:0002154)2.45224388
45X-linked dominant inheritance (HP:0001423)2.42509025
46Retinal dysplasia (HP:0007973)2.39535536
47Septo-optic dysplasia (HP:0100842)2.38970828
48Pallor (HP:0000980)2.35102265
49Nephronophthisis (HP:0000090)2.32750559
50Congenital ichthyosiform erythroderma (HP:0007431)2.32509788
51Emotional lability (HP:0000712)2.31250567
52Abnormality of the anterior horn cell (HP:0006802)2.30878094
53Degeneration of anterior horn cells (HP:0002398)2.30878094
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.27529399
55Absent/shortened dynein arms (HP:0200106)2.27529399
56Lethargy (HP:0001254)2.26596818
57Stenosis of the external auditory canal (HP:0000402)2.26303594
58Type II lissencephaly (HP:0007260)2.25053527
59Neuroendocrine neoplasm (HP:0100634)2.24704782
60Abnormal ciliary motility (HP:0012262)2.20371211
61Delusions (HP:0000746)2.18872594
62Irregular epiphyses (HP:0010582)2.17645379
63Poor suck (HP:0002033)2.15689482
64Nephrogenic diabetes insipidus (HP:0009806)2.11980127
65Optic nerve hypoplasia (HP:0000609)2.11970951
66Birth length less than 3rd percentile (HP:0003561)2.11811363
67Abnormality of placental membranes (HP:0011409)2.11573742
68Amniotic constriction ring (HP:0009775)2.11573742
69Colon cancer (HP:0003003)2.10874135
70Sclerocornea (HP:0000647)2.09471519
71Dicarboxylic aciduria (HP:0003215)2.08421080
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08421080
73Abnormal protein glycosylation (HP:0012346)2.06357439
74Abnormal glycosylation (HP:0012345)2.06357439
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06357439
76Abnormal protein N-linked glycosylation (HP:0012347)2.06357439
77Glycosuria (HP:0003076)2.03803859
78Abnormality of urine glucose concentration (HP:0011016)2.03803859
79Abnormal respiratory motile cilium physiology (HP:0012261)2.02185062
80Breast hypoplasia (HP:0003187)2.00725211
81Anophthalmia (HP:0000528)2.00326638
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.00217129
83Rough bone trabeculation (HP:0100670)1.99990369
84Hypoplastic left heart (HP:0004383)1.99084272
85Abnormality of methionine metabolism (HP:0010901)1.97724183
86Microvesicular hepatic steatosis (HP:0001414)1.94447194
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.93589370
88Methylmalonic aciduria (HP:0012120)1.92647465
89Generalized aminoaciduria (HP:0002909)1.92343573
90Short tibia (HP:0005736)1.91596143
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90942980
92Hyperphosphaturia (HP:0003109)1.89233582
93Pheochromocytoma (HP:0002666)1.89106410
94Abnormality of the labia minora (HP:0012880)1.88282646
95Multiple enchondromatosis (HP:0005701)1.85555492
96Lissencephaly (HP:0001339)1.81387579
97Oral leukoplakia (HP:0002745)1.80334044
98Absent thumb (HP:0009777)1.79669306
99Blindness (HP:0000618)1.78402475
100Autoamputation (HP:0001218)1.76507648
101Reduced antithrombin III activity (HP:0001976)1.76166301
102Abnormality of serum amino acid levels (HP:0003112)1.75919922
103Spastic paraparesis (HP:0002313)1.75741655
104Hypoglycemic coma (HP:0001325)1.75493069
105Pancreatic fibrosis (HP:0100732)1.75275538
106Type 2 muscle fiber atrophy (HP:0003554)1.74211225
107Abnormality of the axillary hair (HP:0100134)1.74087773
108Abnormality of secondary sexual hair (HP:0009888)1.74087773
109Delayed myelination (HP:0012448)1.73506656
110Vaginal atresia (HP:0000148)1.73014996
111Hypothermia (HP:0002045)1.72457655
112Palpitations (HP:0001962)1.72441721
113Myokymia (HP:0002411)1.72159641
114Renal tubular dysfunction (HP:0000124)1.68637127
115Abnormality of alanine metabolism (HP:0010916)1.67749476
116Hyperalaninemia (HP:0003348)1.67749476
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67749476
118True hermaphroditism (HP:0010459)1.67739140
119Abnormal pupillary function (HP:0007686)1.66437452
120Type I transferrin isoform profile (HP:0003642)1.66047636
121Adrenal hypoplasia (HP:0000835)1.64780035
122Aplastic anemia (HP:0001915)1.63798608
123Gait imbalance (HP:0002141)1.63538083
124Unsteady gait (HP:0002317)1.62848666
125Congenital, generalized hypertrichosis (HP:0004540)1.61107319
126CNS hypomyelination (HP:0003429)1.60713433
127Postnatal microcephaly (HP:0005484)1.60108657
128Methylmalonic acidemia (HP:0002912)1.58485292
129Pancreatic cysts (HP:0001737)1.57682037
130Glossoptosis (HP:0000162)1.57560054
131Myotonia (HP:0002486)1.56768297
132Carpal bone hypoplasia (HP:0001498)1.56404479
133Medial flaring of the eyebrow (HP:0010747)1.55099025
134Neoplasm of the adrenal gland (HP:0100631)1.55098212
135Hypoplastic heart (HP:0001961)1.54561168
136Congenital primary aphakia (HP:0007707)1.52772253
137Secondary amenorrhea (HP:0000869)1.52470295
138Vomiting (HP:0002013)1.52245298
139Gliosis (HP:0002171)1.50539223
140Aplasia/hypoplasia of the uterus (HP:0008684)1.49959530
141Abnormal trabecular bone morphology (HP:0100671)1.49031904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.41373032
2VRK23.74649871
3NME23.55031408
4BUB13.25866846
5MAP3K122.79245045
6NME12.60382573
7ARAF2.53951415
8EIF2AK12.48695512
9CASK2.31965315
10WEE12.30877440
11PIM22.25908309
12MAP4K22.11900746
13MYLK2.09240246
14MST42.01882584
15DYRK21.98825777
16LIMK11.96803731
17EIF2AK31.95297880
18BCR1.82094982
19VRK11.78727379
20EPHB21.75236304
21MARK11.65053464
22MAPK131.63772077
23SRPK11.62398225
24CDC71.48243132
25PNCK1.45458835
26BRSK11.44604661
27TRIM281.31969954
28BMPR1B1.30812728
29GRK51.29909669
30MAP3K41.28983067
31PASK1.27353398
32NUAK11.27232752
33TSSK61.26838790
34CCNB11.26271342
35GRK71.26139881
36TNIK1.23385439
37ADRBK21.22322588
38PLK21.18304241
39CSNK1G31.17731612
40CDK191.17680570
41BRAF1.12970729
42OXSR11.06599274
43STK391.05926804
44CSNK1A1L1.05836746
45CDK81.05577469
46GRK11.04788103
47WNK31.04074344
48MKNK11.02074583
49ILK0.96012315
50PLK30.95580258
51PBK0.95277966
52TESK20.93459299
53MAP2K70.92296901
54AURKA0.92252592
55OBSCN0.90134487
56STK240.87900983
57EIF2AK20.87868208
58CSNK1G10.87062847
59TLK10.84720651
60BRSK20.84495557
61PLK40.84125992
62ABL20.80681668
63BMPR20.80455538
64ACVR1B0.79487596
65RPS6KA50.78559575
66MAPKAPK50.77804476
67KDR0.76596023
68ROCK20.74693263
69TTK0.72912200
70MOS0.71211372
71ADRBK10.70510909
72PDK40.70373409
73PDK30.70373409
74CAMK2B0.69879256
75DAPK10.69429983
76MUSK0.69264698
77DAPK30.68238825
78LRRK20.67852238
79NEK20.66583705
80CSNK1G20.66302679
81NEK10.65081797
82BCKDK0.63439680
83PAK10.62244869
84CHEK20.62090984
85CSNK2A10.61884903
86CAMK2A0.61132580
87CDK140.60135149
88EPHA40.58486496
89PINK10.58393580
90PLK10.57256210
91CAMKK20.57107163
92ZAK0.56577933
93CSNK2A20.56497999
94PRKD30.56359971
95CDK180.55612516
96RPS6KA40.55261567
97PRKCI0.55069267
98AKT30.53311765
99STK40.52468860
100ATR0.52448160
101CAMK2D0.51082260
102UHMK10.50444360
103NTRK20.49999580
104MINK10.49356913
105STK38L0.49230971
106CDK150.48216394
107PRPF4B0.47905359
108PHKG20.47556217
109PHKG10.47556217
110PKN10.47276679
111NTRK30.47129069
112PTK2B0.46362365
113AURKB0.46278103
114RAF10.46115760
115PRKCG0.45924042
116DYRK30.44851800
117CDK11A0.44827284
118ERBB30.44754961
119MAP2K40.43955240
120TIE10.43943256
121DYRK1A0.43699418
122ERBB40.43506309
123CLK10.43490068
124TESK10.42544311
125CAMK2G0.41618436
126TGFBR10.40955581
127RPS6KB20.40836224
128PDK20.39830217
129PRKCE0.39292691
130TAF10.35159773
131CAMK10.35137629

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.21894793
2Ribosome_Homo sapiens_hsa030104.87770610
3Proteasome_Homo sapiens_hsa030504.82868804
4Parkinsons disease_Homo sapiens_hsa050124.51520648
5RNA polymerase_Homo sapiens_hsa030203.46534926
6Alzheimers disease_Homo sapiens_hsa050103.33906194
7Huntingtons disease_Homo sapiens_hsa050163.29696232
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.72182029
9Protein export_Homo sapiens_hsa030602.44631378
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17269336
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99454932
12Cardiac muscle contraction_Homo sapiens_hsa042601.99241465
13* Pyrimidine metabolism_Homo sapiens_hsa002401.92599242
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74545691
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65052332
16DNA replication_Homo sapiens_hsa030301.64350755
17Spliceosome_Homo sapiens_hsa030401.64015219
18Fatty acid elongation_Homo sapiens_hsa000621.62231781
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61321329
20Nucleotide excision repair_Homo sapiens_hsa034201.60963563
21Fanconi anemia pathway_Homo sapiens_hsa034601.47869671
22Mismatch repair_Homo sapiens_hsa034301.40687330
23Collecting duct acid secretion_Homo sapiens_hsa049661.40263174
24Basal transcription factors_Homo sapiens_hsa030221.37332396
25Steroid biosynthesis_Homo sapiens_hsa001001.33258955
26Glutathione metabolism_Homo sapiens_hsa004801.26848391
27* Purine metabolism_Homo sapiens_hsa002301.21434126
28Vitamin B6 metabolism_Homo sapiens_hsa007501.21422563
29RNA transport_Homo sapiens_hsa030131.19939641
30Homologous recombination_Homo sapiens_hsa034401.19377761
31Pyruvate metabolism_Homo sapiens_hsa006201.04956627
32Sulfur metabolism_Homo sapiens_hsa009201.03339820
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93727016
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92850719
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91971834
36Carbon metabolism_Homo sapiens_hsa012000.91610393
37Metabolic pathways_Homo sapiens_hsa011000.90826290
38Vibrio cholerae infection_Homo sapiens_hsa051100.90153892
39Base excision repair_Homo sapiens_hsa034100.89932429
40Folate biosynthesis_Homo sapiens_hsa007900.84519568
41Propanoate metabolism_Homo sapiens_hsa006400.79798161
42Sulfur relay system_Homo sapiens_hsa041220.78820891
43RNA degradation_Homo sapiens_hsa030180.78672685
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.77689386
45Tryptophan metabolism_Homo sapiens_hsa003800.77308624
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75431445
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74873844
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71339407
49Butanoate metabolism_Homo sapiens_hsa006500.71278249
50Regulation of autophagy_Homo sapiens_hsa041400.70601281
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70136569
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69669718
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69441122
54Selenocompound metabolism_Homo sapiens_hsa004500.68442010
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68364734
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67094737
57Arachidonic acid metabolism_Homo sapiens_hsa005900.66653847
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66287691
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.66281125
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.63972285
61Phenylalanine metabolism_Homo sapiens_hsa003600.62088803
62Peroxisome_Homo sapiens_hsa041460.61960143
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61717994
64Fatty acid degradation_Homo sapiens_hsa000710.60702570
65Pentose phosphate pathway_Homo sapiens_hsa000300.60464533
66Arginine and proline metabolism_Homo sapiens_hsa003300.59367442
67Tyrosine metabolism_Homo sapiens_hsa003500.58698142
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57455029
69Non-homologous end-joining_Homo sapiens_hsa034500.57166649
70Biosynthesis of amino acids_Homo sapiens_hsa012300.56979521
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52865687
72Rheumatoid arthritis_Homo sapiens_hsa053230.52494158
73Chemical carcinogenesis_Homo sapiens_hsa052040.50479901
74p53 signaling pathway_Homo sapiens_hsa041150.47864064
75Ether lipid metabolism_Homo sapiens_hsa005650.47781984
76Nicotine addiction_Homo sapiens_hsa050330.47623929
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46869944
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.46853706
79Epstein-Barr virus infection_Homo sapiens_hsa051690.45927154
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45355125
81Fructose and mannose metabolism_Homo sapiens_hsa000510.42871256
82Hedgehog signaling pathway_Homo sapiens_hsa043400.42517043
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41560390
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40893943
85Alcoholism_Homo sapiens_hsa050340.40632058
86Linoleic acid metabolism_Homo sapiens_hsa005910.40536195
87Galactose metabolism_Homo sapiens_hsa000520.39680803
88N-Glycan biosynthesis_Homo sapiens_hsa005100.39453640
89Serotonergic synapse_Homo sapiens_hsa047260.39052865
90Basal cell carcinoma_Homo sapiens_hsa052170.37641839
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36022312
92Synaptic vesicle cycle_Homo sapiens_hsa047210.35870673
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35360329
94Sphingolipid metabolism_Homo sapiens_hsa006000.34673708
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33857357
96Phagosome_Homo sapiens_hsa041450.33850551
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33532979
98Cell cycle_Homo sapiens_hsa041100.33225241
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32411117
100Phototransduction_Homo sapiens_hsa047440.29920164
101Histidine metabolism_Homo sapiens_hsa003400.29778914
102Nitrogen metabolism_Homo sapiens_hsa009100.27450609
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27193711
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25782646
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.22528024
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22493960
107Fatty acid metabolism_Homo sapiens_hsa012120.21103169
108Allograft rejection_Homo sapiens_hsa053300.21020601
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19590679
110Asthma_Homo sapiens_hsa053100.19170112
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.18725996
112Oocyte meiosis_Homo sapiens_hsa041140.18669266
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18469502
114beta-Alanine metabolism_Homo sapiens_hsa004100.17815879
115One carbon pool by folate_Homo sapiens_hsa006700.16259409
116Retinol metabolism_Homo sapiens_hsa008300.14299898
117Systemic lupus erythematosus_Homo sapiens_hsa053220.13483444
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.12831129
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12653260
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12602360
121mRNA surveillance pathway_Homo sapiens_hsa030150.10401199
122GABAergic synapse_Homo sapiens_hsa047270.10033302

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