NUDT16P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.54892630
2detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.15431889
3DNA methylation involved in gamete generation (GO:0043046)4.01875527
4signal peptide processing (GO:0006465)3.96190134
5regulation of meiosis I (GO:0060631)3.74416054
6platelet dense granule organization (GO:0060155)3.71429459
7photoreceptor cell maintenance (GO:0045494)3.67554583
8indolalkylamine metabolic process (GO:0006586)3.60462528
9synapsis (GO:0007129)3.60316381
10reciprocal DNA recombination (GO:0035825)3.51997340
11reciprocal meiotic recombination (GO:0007131)3.51997340
12indole-containing compound catabolic process (GO:0042436)3.50446313
13indolalkylamine catabolic process (GO:0046218)3.50446313
14tryptophan catabolic process (GO:0006569)3.50446313
15neural tube formation (GO:0001841)3.33057663
16kynurenine metabolic process (GO:0070189)3.32496341
17L-fucose catabolic process (GO:0042355)3.32061338
18fucose catabolic process (GO:0019317)3.32061338
19L-fucose metabolic process (GO:0042354)3.32061338
20regulation of protein glycosylation (GO:0060049)3.32023233
21proteasome assembly (GO:0043248)3.31466747
22cellular ketone body metabolic process (GO:0046950)3.21451951
23DNA double-strand break processing (GO:0000729)3.20931675
24branched-chain amino acid catabolic process (GO:0009083)3.15113900
25tryptophan metabolic process (GO:0006568)3.13973135
26respiratory chain complex IV assembly (GO:0008535)3.10740054
27drug catabolic process (GO:0042737)3.07777721
28regulation of hippo signaling (GO:0035330)3.04192439
29xenobiotic catabolic process (GO:0042178)2.99795567
30somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98242124
31somatic hypermutation of immunoglobulin genes (GO:0016446)2.98242124
32ketone body metabolic process (GO:1902224)2.96548693
33male meiosis (GO:0007140)2.95923909
34cilium or flagellum-dependent cell motility (GO:0001539)2.95852391
35oxidative demethylation (GO:0070989)2.90523409
36male meiosis I (GO:0007141)2.82785363
37cellular biogenic amine catabolic process (GO:0042402)2.81191605
38amine catabolic process (GO:0009310)2.81191605
39regulation of triglyceride catabolic process (GO:0010896)2.79326180
40gene silencing by RNA (GO:0031047)2.77884383
41negative regulation of DNA-dependent DNA replication (GO:2000104)2.76590542
42double-strand break repair via homologous recombination (GO:0000724)2.75621668
43regulation of gene silencing by RNA (GO:0060966)2.75195528
44regulation of posttranscriptional gene silencing (GO:0060147)2.75195528
45regulation of gene silencing by miRNA (GO:0060964)2.75195528
46response to nitrosative stress (GO:0051409)2.74738369
47flavonoid metabolic process (GO:0009812)2.74573868
48recombinational repair (GO:0000725)2.74206773
49dopamine transport (GO:0015872)2.73748111
50aromatic amino acid family catabolic process (GO:0009074)2.73683566
51cellular glucuronidation (GO:0052695)2.71883221
52single strand break repair (GO:0000012)2.71763050
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71608709
54replication fork processing (GO:0031297)2.71475427
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71142367
56uronic acid metabolic process (GO:0006063)2.69969019
57glucuronate metabolic process (GO:0019585)2.69969019
58amino acid salvage (GO:0043102)2.68425127
59L-methionine salvage (GO:0071267)2.68425127
60L-methionine biosynthetic process (GO:0071265)2.68425127
61exogenous drug catabolic process (GO:0042738)2.67956431
62axoneme assembly (GO:0035082)2.65781084
63bile acid biosynthetic process (GO:0006699)2.65775624
64cytochrome complex assembly (GO:0017004)2.65618118
65regulation of memory T cell differentiation (GO:0043380)2.63921430
66monoubiquitinated protein deubiquitination (GO:0035520)2.62195026
67DNA integration (GO:0015074)2.61155852
68branched-chain amino acid metabolic process (GO:0009081)2.59259141
69anterograde synaptic vesicle transport (GO:0048490)2.58260908
70aromatic amino acid family metabolic process (GO:0009072)2.57808668
71drug metabolic process (GO:0017144)2.57048747
72aspartate family amino acid catabolic process (GO:0009068)2.56855427
73methionine metabolic process (GO:0006555)2.56806702
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55510815
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55510815
76mannosylation (GO:0097502)2.55193299
77UDP-N-acetylglucosamine metabolic process (GO:0006047)2.55062546
78nucleotide transmembrane transport (GO:1901679)2.54913803
79methionine biosynthetic process (GO:0009086)2.53609614
80meiotic chromosome segregation (GO:0045132)2.51641512
81benzene-containing compound metabolic process (GO:0042537)2.51255040
82prenylation (GO:0097354)2.50977411
83protein prenylation (GO:0018342)2.50977411
84indole-containing compound metabolic process (GO:0042430)2.49435831
85water-soluble vitamin biosynthetic process (GO:0042364)2.48039982
86cell wall macromolecule catabolic process (GO:0016998)2.47082236
87pseudouridine synthesis (GO:0001522)2.45915352
88dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.43268657
89detection of light stimulus involved in sensory perception (GO:0050962)2.42250654
90detection of light stimulus involved in visual perception (GO:0050908)2.42250654
91sphingoid metabolic process (GO:0046519)2.41331964
92DNA catabolic process, exonucleolytic (GO:0000738)2.41265402
93preassembly of GPI anchor in ER membrane (GO:0016254)2.40998702
94regulation of cilium movement (GO:0003352)2.40973544
95DNA deamination (GO:0045006)2.39673354
96protein K11-linked ubiquitination (GO:0070979)2.38600736
97retinal cone cell development (GO:0046549)2.33734925
98interleukin-6-mediated signaling pathway (GO:0070102)2.33128977
99sulfur amino acid biosynthetic process (GO:0000097)2.33088707
100auditory receptor cell stereocilium organization (GO:0060088)2.32061914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.22151226
2IGF1R_20145208_ChIP-Seq_DFB_Human3.18342114
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69301844
4ZNF274_21170338_ChIP-Seq_K562_Hela2.64231801
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47342611
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.45269260
7TAF15_26573619_Chip-Seq_HEK293_Human2.43102972
8GBX2_23144817_ChIP-Seq_PC3_Human2.31241958
9P300_19829295_ChIP-Seq_ESCs_Human2.20264901
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19961838
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13418696
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.05795847
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02218861
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01097559
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95399480
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94185341
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91432207
18ER_23166858_ChIP-Seq_MCF-7_Human1.90952712
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90000072
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89722176
21EWS_26573619_Chip-Seq_HEK293_Human1.89418577
22IRF1_19129219_ChIP-ChIP_H3396_Human1.87668252
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87176198
24FUS_26573619_Chip-Seq_HEK293_Human1.76696717
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.72002505
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65466058
27BCAT_22108803_ChIP-Seq_LS180_Human1.62876371
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60372835
29STAT3_23295773_ChIP-Seq_U87_Human1.58897188
30ELK1_19687146_ChIP-ChIP_HELA_Human1.56990612
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55224979
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.52691018
33CBP_20019798_ChIP-Seq_JUKART_Human1.52145221
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52145221
35TCF4_22108803_ChIP-Seq_LS180_Human1.50045869
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49627652
37SOX2_19829295_ChIP-Seq_ESCs_Human1.49059996
38NANOG_19829295_ChIP-Seq_ESCs_Human1.49059996
39CDX2_22108803_ChIP-Seq_LS180_Human1.48777699
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46447031
41SMAD4_21799915_ChIP-Seq_A2780_Human1.44686434
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.42960791
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.40710053
44* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38964607
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36694123
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35449018
47TCF4_23295773_ChIP-Seq_U87_Human1.33022777
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.32662363
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32123785
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32123785
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31038944
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30833329
53TP53_22573176_ChIP-Seq_HFKS_Human1.29492954
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.27609397
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27384801
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25825077
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25614712
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.25614712
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24076164
60AR_20517297_ChIP-Seq_VCAP_Human1.23649194
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.21176859
62AR_25329375_ChIP-Seq_VCAP_Human1.20245916
63RUNX2_22187159_ChIP-Seq_PCA_Human1.19785537
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.19133018
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.18674325
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18387459
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18108467
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.17671253
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16123693
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.16044515
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15410366
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.15201503
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14689622
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.13456865
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11550753
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10717085
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09321726
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08054031
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07119077
80* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05776751
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.05668482
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05652942
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.03962478
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03532750
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02613680
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01744429
87VDR_23849224_ChIP-Seq_CD4+_Human1.01708911
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01607228
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00630449
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00538442
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99579725
92GATA3_26560356_Chip-Seq_TH2_Human0.99115410
93PHF8_20622853_ChIP-Seq_HELA_Human0.97261478
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.97180200
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96335275
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.96040312
97NCOR_22424771_ChIP-Seq_293T_Human0.94867873
98HOXB7_26014856_ChIP-Seq_BT474_Human0.94175552
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.94124713
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93661881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.97556391
2MP0008877_abnormal_DNA_methylation3.86868034
3MP0005085_abnormal_gallbladder_physiolo3.40963871
4MP0004147_increased_porphyrin_level2.65630383
5MP0003718_maternal_effect2.58981001
6MP0008057_abnormal_DNA_replication2.56529527
7MP0005365_abnormal_bile_salt2.51852908
8MP0002138_abnormal_hepatobiliary_system2.46771477
9MP0000569_abnormal_digit_pigmentation2.25779741
10MP0000372_irregular_coat_pigmentation2.21772634
11MP0003136_yellow_coat_color2.15204059
12MP0008875_abnormal_xenobiotic_pharmacok2.12085371
13MP0005551_abnormal_eye_electrophysiolog2.05361653
14MP0005360_urolithiasis2.01816745
15MP0005670_abnormal_white_adipose2.01778460
16MP0002102_abnormal_ear_morphology1.99845135
17MP0008058_abnormal_DNA_repair1.98878629
18MP0002139_abnormal_hepatobiliary_system1.96666281
19MP0002254_reproductive_system_inflammat1.95382034
20MP0003252_abnormal_bile_duct1.95213865
21MP0000427_abnormal_hair_cycle1.92126650
22MP0009697_abnormal_copulation1.76552936
23MP0003806_abnormal_nucleotide_metabolis1.75976752
24MP0003646_muscle_fatigue1.75463721
25MP0001485_abnormal_pinna_reflex1.75253749
26MP0001764_abnormal_homeostasis1.75166442
27MP0005174_abnormal_tail_pigmentation1.64133374
28MP0005395_other_phenotype1.60490937
29MP0005253_abnormal_eye_physiology1.53750044
30MP0000015_abnormal_ear_pigmentation1.52459010
31MP0003950_abnormal_plasma_membrane1.47098691
32MP0003878_abnormal_ear_physiology1.44907812
33MP0005377_hearing/vestibular/ear_phenot1.44907812
34MP0005075_abnormal_melanosome_morpholog1.43817075
35MP0002090_abnormal_vision1.43045136
36MP0003724_increased_susceptibility_to1.41251722
37MP0008872_abnormal_physiological_respon1.37199401
38MP0010094_abnormal_chromosome_stability1.33544578
39MP0001501_abnormal_sleep_pattern1.32814660
40MP0002736_abnormal_nociception_after1.31985307
41MP0002837_dystrophic_cardiac_calcinosis1.30045684
42MP0002876_abnormal_thyroid_physiology1.29394590
43MP0005332_abnormal_amino_acid1.28200996
44MP0001929_abnormal_gametogenesis1.25459791
45MP0005084_abnormal_gallbladder_morpholo1.24961411
46MP0005410_abnormal_fertilization1.21463297
47MP0005647_abnormal_sex_gland1.19332980
48MP0006072_abnormal_retinal_apoptosis1.17567938
49MP0002132_abnormal_respiratory_system1.17205142
50MP0001324_abnormal_eye_pigmentation1.16479777
51MP0003890_abnormal_embryonic-extraembry1.15346021
52MP0006035_abnormal_mitochondrial_morpho1.14532351
53MP0003011_delayed_dark_adaptation1.13311000
54MP0004957_abnormal_blastocyst_morpholog1.12426228
55MP0001666_abnormal_nutrient_absorption1.11965395
56MP0003191_abnormal_cellular_cholesterol1.11847670
57MP0006082_CNS_inflammation1.11673886
58MP0003693_abnormal_embryo_hatching1.10215866
59MP0000371_diluted_coat_color1.08249406
60MP0006292_abnormal_olfactory_placode1.07631724
61MP0003186_abnormal_redox_activity1.06313852
62MP0004019_abnormal_vitamin_homeostasis1.04826479
63MP0003656_abnormal_erythrocyte_physiolo1.04104377
64MP0003787_abnormal_imprinting1.03682128
65MP0000383_abnormal_hair_follicle1.03141097
66MP0002168_other_aberrant_phenotype1.00761614
67MP0001986_abnormal_taste_sensitivity1.00618043
68MP0002938_white_spotting1.00471661
69MP0002095_abnormal_skin_pigmentation0.99768236
70MP0003943_abnormal_hepatobiliary_system0.98282416
71MP0003698_abnormal_male_reproductive0.97610687
72MP0001968_abnormal_touch/_nociception0.95328858
73MP0005408_hypopigmentation0.94240689
74MP0010329_abnormal_lipoprotein_level0.94110239
75MP0005636_abnormal_mineral_homeostasis0.93754787
76MP0000653_abnormal_sex_gland0.91787484
77MP0003786_premature_aging0.90354182
78MP0002210_abnormal_sex_determination0.89743720
79MP0005310_abnormal_salivary_gland0.89613815
80MP0005464_abnormal_platelet_physiology0.87627421
81MP0000358_abnormal_cell_content/0.86863427
82MP0009046_muscle_twitch0.85437169
83MP0006036_abnormal_mitochondrial_physio0.84853178
84MP0004215_abnormal_myocardial_fiber0.84823883
85MP0001529_abnormal_vocalization0.82835754
86MP0001145_abnormal_male_reproductive0.82691801
87MP0003183_abnormal_peptide_metabolism0.82595153
88MP0004264_abnormal_extraembryonic_tissu0.81139785
89MP0009764_decreased_sensitivity_to0.78805770
90MP0010678_abnormal_skin_adnexa0.75633785
91MP0003045_fibrosis0.75047464
92MP0005083_abnormal_biliary_tract0.74214566
93MP0005376_homeostasis/metabolism_phenot0.74075570
94MP0003111_abnormal_nucleus_morphology0.72940159
95MP0002148_abnormal_hypersensitivity_rea0.72814974
96MP0005319_abnormal_enzyme/_coenzyme0.72723161
97MP0005266_abnormal_metabolism0.71484165
98MP0002653_abnormal_ependyma_morphology0.71106630
99MP0006054_spinal_hemorrhage0.68787578
100MP0000647_abnormal_sebaceous_gland0.68603712

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.01112763
2Pancreatic fibrosis (HP:0100732)3.47980730
3True hermaphroditism (HP:0010459)3.32927388
4Aplasia/Hypoplasia of the tibia (HP:0005772)3.15031069
5Molar tooth sign on MRI (HP:0002419)2.96416285
6Abnormality of midbrain morphology (HP:0002418)2.96416285
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73526094
8Abnormality of alanine metabolism (HP:0010916)2.73526094
9Hyperalaninemia (HP:0003348)2.73526094
10Gaze-evoked nystagmus (HP:0000640)2.69417959
11Medial flaring of the eyebrow (HP:0010747)2.66154513
12Hyperglycinemia (HP:0002154)2.63798562
13Nephronophthisis (HP:0000090)2.62286062
14Hyperglycinuria (HP:0003108)2.60101476
15Type I transferrin isoform profile (HP:0003642)2.55221507
16Abnormality of the renal cortex (HP:0011035)2.54370546
17Albinism (HP:0001022)2.53679304
18Abolished electroretinogram (ERG) (HP:0000550)2.53029820
19Short tibia (HP:0005736)2.51415936
20Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51253766
21Attenuation of retinal blood vessels (HP:0007843)2.47804562
22Abnormality of serine family amino acid metabolism (HP:0010894)2.47415324
23Abnormality of glycine metabolism (HP:0010895)2.47415324
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.45812233
25Congenital stationary night blindness (HP:0007642)2.38864586
26Abnormality of the renal medulla (HP:0100957)2.38501278
27Abnormality of the labia minora (HP:0012880)2.34187489
28Methylmalonic acidemia (HP:0002912)2.33500321
29Stomach cancer (HP:0012126)2.32457805
30Abnormality of serum amino acid levels (HP:0003112)2.32248915
31Amelogenesis imperfecta (HP:0000705)2.30036060
32Methylmalonic aciduria (HP:0012120)2.28063302
33Abnormality of methionine metabolism (HP:0010901)2.27260554
34Abnormal biliary tract physiology (HP:0012439)2.27136376
35Bile duct proliferation (HP:0001408)2.27136376
36Cystic liver disease (HP:0006706)2.26036990
37Congenital hepatic fibrosis (HP:0002612)2.24922855
38Pancreatic islet-cell hyperplasia (HP:0004510)2.21229971
39Intrahepatic cholestasis (HP:0001406)2.16285166
40Congenital sensorineural hearing impairment (HP:0008527)2.15748002
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15161724
42Abnormal protein N-linked glycosylation (HP:0012347)2.15161724
43Abnormal protein glycosylation (HP:0012346)2.15161724
44Abnormal glycosylation (HP:0012345)2.15161724
45Congenital primary aphakia (HP:0007707)2.13798582
46Chronic hepatic failure (HP:0100626)2.13720649
47Oculomotor apraxia (HP:0000657)2.11226054
48Azoospermia (HP:0000027)2.08913237
49Abnormality of macular pigmentation (HP:0008002)2.06931158
50Median cleft lip (HP:0000161)2.06086332
51Renal cortical cysts (HP:0000803)2.04108028
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03087193
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02869469
54Decreased central vision (HP:0007663)1.99874299
55Enlarged kidneys (HP:0000105)1.99803730
56Postaxial foot polydactyly (HP:0001830)1.98944411
57Severe visual impairment (HP:0001141)1.97207659
58Abnormality of the vitamin B12 metabolism (HP:0004341)1.96483812
59Central scotoma (HP:0000603)1.95323688
60Gait imbalance (HP:0002141)1.94733576
61Facial diplegia (HP:0001349)1.93536903
62Abnormality of vitamin B metabolism (HP:0004340)1.89110928
63Anencephaly (HP:0002323)1.88660439
64Genital tract atresia (HP:0001827)1.86793982
65Bifid tongue (HP:0010297)1.85682922
66Nephrogenic diabetes insipidus (HP:0009806)1.85613698
67Ileus (HP:0002595)1.84641155
68Abnormality of sulfur amino acid metabolism (HP:0004339)1.81675855
69Fair hair (HP:0002286)1.80578896
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.80377713
71Abnormal respiratory motile cilium physiology (HP:0012261)1.79469599
72Male pseudohermaphroditism (HP:0000037)1.78525283
73Intestinal atresia (HP:0011100)1.76621464
74Abnormality of chromosome stability (HP:0003220)1.76266078
75Abnormal spermatogenesis (HP:0008669)1.76186918
76Vaginal atresia (HP:0000148)1.75711072
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.75603853
78Retinitis pigmentosa (HP:0000510)1.75521637
79Progressive inability to walk (HP:0002505)1.75487417
80Bony spicule pigmentary retinopathy (HP:0007737)1.73459046
81Stomatitis (HP:0010280)1.73456467
82Chronic bronchitis (HP:0004469)1.72946337
83Preaxial hand polydactyly (HP:0001177)1.72943310
84Reduced antithrombin III activity (HP:0001976)1.72705410
85Vacuolated lymphocytes (HP:0001922)1.72410500
86Asplenia (HP:0001746)1.72117820
87Constricted visual fields (HP:0001133)1.71861890
88Optic neuritis (HP:0100653)1.71220840
89Retrobulbar optic neuritis (HP:0100654)1.71220840
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69763695
91Sclerocornea (HP:0000647)1.69064095
92Small hand (HP:0200055)1.66933115
93Abnormality of the preputium (HP:0100587)1.66169434
94Ketosis (HP:0001946)1.65789365
95Sloping forehead (HP:0000340)1.65766231
96Homocystinuria (HP:0002156)1.65668438
97Abnormality of homocysteine metabolism (HP:0010919)1.65668438
98Abnormal ciliary motility (HP:0012262)1.64806560
99Supernumerary spleens (HP:0009799)1.63859173
100Hypochromic microcytic anemia (HP:0004840)1.63513246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.96483718
2ACVR1B3.63124515
3BMPR1B3.38814312
4MAP4K22.75466567
5MST42.54050153
6NUAK12.50045582
7ZAK2.42266891
8WNK32.28389168
9TRIM282.21449395
10EIF2AK32.14234508
11INSRR1.96689574
12BUB11.84988357
13STK38L1.83119434
14STK31.79154393
15ADRBK21.73004106
16PDK21.66355375
17GRK11.61115800
18FER1.59209743
19LATS11.43207607
20PBK1.43002928
21OXSR11.41854521
22MKNK21.40843343
23SIK31.37593145
24PIK3CG1.34784979
25TNIK1.32040064
26PINK11.31322094
27MET1.25654668
28PLK41.24292489
29BRSK21.23348411
30BCR1.23163519
31TAF11.19587349
32MAP3K121.18808819
33ERBB31.18291471
34EIF2AK11.16868863
35TEC1.09030352
36PAK31.07611950
37PLK31.04366113
38TNK21.02976768
39TTK1.00474957
40STK391.00264459
41BCKDK0.98757548
42MKNK10.98350033
43TAOK30.98274637
44PRKCE0.92588225
45STK160.92472131
46CDK190.91860086
47MAPK130.89549472
48IRAK10.89249033
49TGFBR10.85966745
50NLK0.85274300
51MST1R0.85221331
52MAP3K40.84403069
53PTK2B0.81994499
54PLK10.72580084
55SRPK10.72401508
56MAP3K20.69906331
57CSNK1G10.69684085
58STK380.67702717
59PLK20.65464879
60BMPR20.64538729
61NME10.62527037
62CSNK1G20.59998417
63STK40.59422260
64EIF2AK20.57196537
65DYRK30.57182449
66AKT30.57006815
67YES10.56541404
68LMTK20.56205876
69ADRBK10.54709862
70VRK10.49504599
71NEK10.47146617
72MARK30.47143302
73CDC70.47091049
74CSNK1G30.46896422
75VRK20.45886019
76CSNK1A1L0.44573895
77STK240.44166105
78DAPK20.43615752
79STK100.42132759
80MUSK0.40544444
81TXK0.38129286
82FES0.37592629
83CSF1R0.37162512
84GRK70.36682438
85WEE10.36319649
86NTRK30.35383464
87FGR0.35282245
88PRKCQ0.35112316
89MATK0.34046724
90PRKCI0.33219376
91RAF10.32453352
92NEK20.31628827
93PRKCG0.31603832
94EGFR0.31033359
95IGF1R0.30713461
96MAP2K70.30231367
97TSSK60.28560781
98ATM0.28356056
99PKN10.27919671
100CASK0.27896234

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.72077794
2Homologous recombination_Homo sapiens_hsa034402.65024671
3Butanoate metabolism_Homo sapiens_hsa006502.54849167
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42443980
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42004850
6Caffeine metabolism_Homo sapiens_hsa002322.35050528
7Propanoate metabolism_Homo sapiens_hsa006402.22955702
8Proteasome_Homo sapiens_hsa030502.21303572
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12071516
10Tryptophan metabolism_Homo sapiens_hsa003802.04023219
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96538751
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94147322
13Retinol metabolism_Homo sapiens_hsa008301.91800946
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84698199
15Linoleic acid metabolism_Homo sapiens_hsa005911.84420988
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83995445
17Chemical carcinogenesis_Homo sapiens_hsa052041.79988113
18Non-homologous end-joining_Homo sapiens_hsa034501.79937392
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76591635
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71799271
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.69341325
22Peroxisome_Homo sapiens_hsa041461.67250993
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64169451
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59981421
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.55462061
26Fatty acid elongation_Homo sapiens_hsa000621.55286918
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52900946
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.51339484
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50816686
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42664356
31beta-Alanine metabolism_Homo sapiens_hsa004101.42537693
32Nitrogen metabolism_Homo sapiens_hsa009101.36993031
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36105794
34Fatty acid degradation_Homo sapiens_hsa000711.34399661
35Base excision repair_Homo sapiens_hsa034101.32921472
36Arachidonic acid metabolism_Homo sapiens_hsa005901.32596257
37Fanconi anemia pathway_Homo sapiens_hsa034601.31570075
38Phototransduction_Homo sapiens_hsa047441.31477003
39ABC transporters_Homo sapiens_hsa020101.28994732
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28603835
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25787677
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24789153
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.22763952
44Mismatch repair_Homo sapiens_hsa034301.21986865
45Fatty acid metabolism_Homo sapiens_hsa012121.19511647
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18786794
47Basal transcription factors_Homo sapiens_hsa030221.16924143
48Histidine metabolism_Homo sapiens_hsa003401.16912344
49Sphingolipid metabolism_Homo sapiens_hsa006001.11024711
50Protein export_Homo sapiens_hsa030601.10694666
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10534376
52Vitamin digestion and absorption_Homo sapiens_hsa049771.08543365
53Sulfur metabolism_Homo sapiens_hsa009201.07308358
54One carbon pool by folate_Homo sapiens_hsa006701.06813821
55Selenocompound metabolism_Homo sapiens_hsa004501.06269114
56Ether lipid metabolism_Homo sapiens_hsa005651.04211523
57Fat digestion and absorption_Homo sapiens_hsa049751.03273364
58Glutathione metabolism_Homo sapiens_hsa004801.02338251
59Starch and sucrose metabolism_Homo sapiens_hsa005001.00839791
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92252983
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88133126
62Glycerolipid metabolism_Homo sapiens_hsa005610.83751966
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80273574
64Metabolic pathways_Homo sapiens_hsa011000.79848212
65RNA polymerase_Homo sapiens_hsa030200.79095593
66Pyruvate metabolism_Homo sapiens_hsa006200.77202844
67Arginine and proline metabolism_Homo sapiens_hsa003300.72811529
68Steroid biosynthesis_Homo sapiens_hsa001000.69977385
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69305585
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68628629
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.68012555
72RNA degradation_Homo sapiens_hsa030180.66209352
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64420544
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62020485
75Pyrimidine metabolism_Homo sapiens_hsa002400.60165535
76Folate biosynthesis_Homo sapiens_hsa007900.59890542
77Circadian rhythm_Homo sapiens_hsa047100.59339483
78Purine metabolism_Homo sapiens_hsa002300.59295433
79Tyrosine metabolism_Homo sapiens_hsa003500.59039322
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58766312
81Olfactory transduction_Homo sapiens_hsa047400.57730971
82Complement and coagulation cascades_Homo sapiens_hsa046100.57069551
83N-Glycan biosynthesis_Homo sapiens_hsa005100.54283230
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53467054
85Mineral absorption_Homo sapiens_hsa049780.49631747
86Regulation of autophagy_Homo sapiens_hsa041400.49158388
87DNA replication_Homo sapiens_hsa030300.47582024
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45723599
89RNA transport_Homo sapiens_hsa030130.45431717
90Nucleotide excision repair_Homo sapiens_hsa034200.41556318
91Arginine biosynthesis_Homo sapiens_hsa002200.40670302
92Legionellosis_Homo sapiens_hsa051340.39905207
93Phenylalanine metabolism_Homo sapiens_hsa003600.39570144
94Staphylococcus aureus infection_Homo sapiens_hsa051500.39186126
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38385489
96PPAR signaling pathway_Homo sapiens_hsa033200.37867129
97Taste transduction_Homo sapiens_hsa047420.37487001
98Oocyte meiosis_Homo sapiens_hsa041140.37081935
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32831401
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31076237

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