NUDT13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)9.84200595
2prenylation (GO:0097354)9.84200595
3positive regulation of mitotic sister chromatid separation (GO:1901970)9.00482469
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)9.00482469
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)9.00482469
6negative regulation of Ras GTPase activity (GO:0034261)6.93202318
7regulation of sister chromatid cohesion (GO:0007063)6.78049359
8positive regulation of chromosome segregation (GO:0051984)6.03971994
9negative regulation of T cell receptor signaling pathway (GO:0050860)6.02176571
10eosinophil chemotaxis (GO:0048245)5.93913647
11double-strand break repair via nonhomologous end joining (GO:0006303)5.68761100
12non-recombinational repair (GO:0000726)5.68761100
13eosinophil migration (GO:0072677)5.41350522
14L-fucose metabolic process (GO:0042354)5.32591171
15L-fucose catabolic process (GO:0042355)5.32591171
16fucose catabolic process (GO:0019317)5.32591171
17negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)5.18961161
18peptidyl-lysine dimethylation (GO:0018027)5.00850882
19ribosomal small subunit assembly (GO:0000028)4.91980512
20branch elongation of an epithelium (GO:0060602)4.88046734
21vesicle fusion (GO:0006906)4.77337644
22regulation of mononuclear cell migration (GO:0071675)4.61992728
23oxygen transport (GO:0015671)4.56823991
24fatty acid elongation (GO:0030497)4.50237236
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33991809
26coenzyme A biosynthetic process (GO:0015937)4.30935226
27telomere maintenance via recombination (GO:0000722)4.29543553
28peptidyl-lysine trimethylation (GO:0018023)4.12541061
29negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.02421757
30oxidative demethylation (GO:0070989)3.91719607
31fatty acid beta-oxidation (GO:0006635)3.91652163
32acrosome assembly (GO:0001675)3.91620758
33respiratory electron transport chain (GO:0022904)3.90986048
34preassembly of GPI anchor in ER membrane (GO:0016254)3.90107843
35mitotic recombination (GO:0006312)3.89331118
36creatine metabolic process (GO:0006600)3.84797231
37erythrocyte maturation (GO:0043249)3.81811717
38electron transport chain (GO:0022900)3.81052189
39autophagic vacuole fusion (GO:0000046)3.81038455
40regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.77603758
41proteasome assembly (GO:0043248)3.76222893
42L-phenylalanine catabolic process (GO:0006559)3.72164593
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72164593
44histone H3-K9 methylation (GO:0051567)3.70138433
45fatty-acyl-CoA metabolic process (GO:0035337)3.65081873
46gas transport (GO:0015669)3.64783387
47fatty acid catabolic process (GO:0009062)3.60684623
48acyl-CoA biosynthetic process (GO:0071616)3.60168882
49thioester biosynthetic process (GO:0035384)3.60168882
50carnitine shuttle (GO:0006853)3.59599976
51regulation of T cell receptor signaling pathway (GO:0050856)3.59464460
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.58379977
53organ growth (GO:0035265)3.58110247
54central nervous system myelination (GO:0022010)3.57184975
55axon ensheathment in central nervous system (GO:0032291)3.57184975
56RNA methylation (GO:0001510)3.56525464
57axis elongation (GO:0003401)3.55455933
58protein K11-linked deubiquitination (GO:0035871)3.53988634
59synapsis (GO:0007129)3.47291557
60regulation of sequestering of triglyceride (GO:0010889)3.46728322
61localization within membrane (GO:0051668)3.46499633
62organelle membrane fusion (GO:0090174)3.45924571
63pantothenate metabolic process (GO:0015939)3.42690731
64detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.42608547
65double-strand break repair via homologous recombination (GO:0000724)3.42396184
66fatty acid oxidation (GO:0019395)3.41389698
67establishment of mitotic spindle orientation (GO:0000132)3.41271020
68negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.39559068
69lipid oxidation (GO:0034440)3.38595424
70fatty acid transmembrane transport (GO:1902001)3.38044148
71nuclear pore complex assembly (GO:0051292)3.35740534
72recombinational repair (GO:0000725)3.35475289
73macrophage chemotaxis (GO:0048246)3.32509528
74establishment of mitotic spindle localization (GO:0040001)3.28466606
75fatty-acyl-CoA biosynthetic process (GO:0046949)3.28450636
76biotin metabolic process (GO:0006768)3.27921200
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27411578
78L-phenylalanine metabolic process (GO:0006558)3.27411578
79DNA integration (GO:0015074)3.26619731
80replication fork processing (GO:0031297)3.22727397
81regulation of stem cell maintenance (GO:2000036)3.22033888
82branched-chain amino acid catabolic process (GO:0009083)3.21301360
83histone H3-K9 modification (GO:0061647)3.20300487
84positive regulation of antigen processing and presentation (GO:0002579)3.19616093
85regulation of DNA endoreduplication (GO:0032875)3.18433752
86short-chain fatty acid metabolic process (GO:0046459)3.17289700
87long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.14775848
88long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.13665298
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12648566
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12648566
91DNA double-strand break processing (GO:0000729)3.12567846
92tricarboxylic acid cycle (GO:0006099)3.11091456
93very long-chain fatty acid metabolic process (GO:0000038)3.10055565
94mitochondrial RNA metabolic process (GO:0000959)3.09765994
95regulation of mitotic sister chromatid separation (GO:0010965)3.08477030
96regulation of mitotic sister chromatid segregation (GO:0033047)3.08477030
97regulation of sister chromatid segregation (GO:0033045)3.08477030
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06174940
99monocarboxylic acid catabolic process (GO:0072329)3.03757453
100telomere maintenance (GO:0000723)3.03015982
101NADH metabolic process (GO:0006734)3.02678435
102telomere organization (GO:0032200)3.02428583
103positive regulation of calcium ion import (GO:0090280)3.01851047
104resolution of meiotic recombination intermediates (GO:0000712)3.00391473
105detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.99919714
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.99739714
107NADH dehydrogenase complex assembly (GO:0010257)2.99739714
108mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99739714
109succinate metabolic process (GO:0006105)2.99445776
110response to nitrosative stress (GO:0051409)2.94195445
111acyl-CoA metabolic process (GO:0006637)2.93828603
112thioester metabolic process (GO:0035383)2.93828603
113establishment of spindle orientation (GO:0051294)2.92843068
114amyloid precursor protein catabolic process (GO:0042987)2.92254936
115fucose metabolic process (GO:0006004)2.89774023
116intracellular pH reduction (GO:0051452)2.89593237
117branched-chain amino acid metabolic process (GO:0009081)2.89060159
118regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.88990307
119acetyl-CoA metabolic process (GO:0006084)2.85282069
120GPI anchor biosynthetic process (GO:0006506)2.85157754
121protein complex biogenesis (GO:0070271)2.83999943
122ATP synthesis coupled proton transport (GO:0015986)2.83923212
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83923212
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.82000231
125cardiolipin metabolic process (GO:0032048)2.81653489
126cytoplasmic mRNA processing body assembly (GO:0033962)2.81216353
127positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78907510
128negative regulation of GTPase activity (GO:0034260)2.77790273
129negative regulation of GTP catabolic process (GO:0033125)2.77790273
130regulation of T-helper 1 cell differentiation (GO:0045625)2.77065697
131mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75835414
1323-UTR-mediated mRNA stabilization (GO:0070935)2.75600410
133organelle fusion (GO:0048284)2.75436564
134kinetochore organization (GO:0051383)2.75315913
135DNA replication checkpoint (GO:0000076)2.75029921
136mitotic sister chromatid segregation (GO:0000070)2.74165869
137purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.73825280
138ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.73825280
139nucleoside bisphosphate biosynthetic process (GO:0033866)2.73825280
140seminiferous tubule development (GO:0072520)2.73598468
141GPI anchor metabolic process (GO:0006505)2.72773517
142galactose catabolic process (GO:0019388)2.71837117
143sister chromatid segregation (GO:0000819)2.71667739
144regulation of acyl-CoA biosynthetic process (GO:0050812)2.71590764
145fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.71394820
146positive regulation of cellular amine metabolic process (GO:0033240)2.70458296
147carnitine transmembrane transport (GO:1902603)2.68716624
148COPII vesicle coating (GO:0048208)2.67987489
149nuclear pore organization (GO:0006999)2.67837574
150folic acid-containing compound biosynthetic process (GO:0009396)2.67142141
151peptidyl-lysine methylation (GO:0018022)2.66815764
152mitotic sister chromatid cohesion (GO:0007064)2.66473863
153response to interferon-beta (GO:0035456)2.66303060
154imidazole-containing compound metabolic process (GO:0052803)2.66159247
155nucleotide transmembrane transport (GO:1901679)2.65934365
156negative regulation of dendrite morphogenesis (GO:0050774)2.65566653
157monocyte chemotaxis (GO:0002548)2.65008446
158polyketide metabolic process (GO:0030638)2.62630842
159doxorubicin metabolic process (GO:0044598)2.62630842
160daunorubicin metabolic process (GO:0044597)2.62630842
161positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.61981613
162respiratory chain complex IV assembly (GO:0008535)2.61109391
163pH reduction (GO:0045851)2.59123400
164coenzyme A metabolic process (GO:0015936)2.58761980
165regulation of antigen processing and presentation (GO:0002577)2.54421270
166myelination (GO:0042552)2.52551407
167response to epinephrine (GO:0071871)2.52395250
168axon ensheathment (GO:0008366)2.51406937
169ensheathment of neurons (GO:0007272)2.51406937
170signal peptide processing (GO:0006465)2.51392857
171inner mitochondrial membrane organization (GO:0007007)2.51382657
172cofactor catabolic process (GO:0051187)2.50580346
173adhesion of symbiont to host cell (GO:0044650)2.50336132
174virion attachment to host cell (GO:0019062)2.50336132
175regulation of cholesterol metabolic process (GO:0090181)2.49673691
176fatty acid homeostasis (GO:0055089)2.49498020
177alpha-linolenic acid metabolic process (GO:0036109)2.49405405
178protein import into peroxisome matrix (GO:0016558)2.48832365
179regulation of cell communication by electrical coupling (GO:0010649)2.48351239
180coenzyme catabolic process (GO:0009109)2.46813079
181amyloid precursor protein metabolic process (GO:0042982)2.46256839
182amino-acid betaine transport (GO:0015838)2.44920859
183carnitine transport (GO:0015879)2.44920859
184valine metabolic process (GO:0006573)2.44419705
185ubiquinone biosynthetic process (GO:0006744)2.42034111
186quinone biosynthetic process (GO:1901663)2.42034111
187T-helper 1 type immune response (GO:0042088)2.41677406
188cellular lipid catabolic process (GO:0044242)2.41469350
189mitochondrial respiratory chain complex assembly (GO:0033108)2.40786260
190L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40181833
191cholesterol biosynthetic process (GO:0006695)2.36623311
192peroxisome organization (GO:0007031)2.36424054
193aspartate family amino acid catabolic process (GO:0009068)2.35641416
194aerobic respiration (GO:0009060)2.35008223
195protein localization to peroxisome (GO:0072662)2.34208853
196protein targeting to peroxisome (GO:0006625)2.34208853
197establishment of protein localization to peroxisome (GO:0072663)2.34208853
198positive regulation of fatty acid oxidation (GO:0046321)2.34132660
199opsonization (GO:0008228)2.34010318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94278160
2E2F7_22180533_ChIP-Seq_HELA_Human4.35235578
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.68210866
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64781868
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62527569
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44548120
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.32660593
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13883195
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.10537726
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.91812695
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.59037932
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.55120076
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.45209067
14ELK1_19687146_ChIP-ChIP_HELA_Human2.42937324
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39647777
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39309319
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34090025
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.29854911
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.19516333
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.18849934
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14477288
22GBX2_23144817_ChIP-Seq_PC3_Human2.12753390
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11100288
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07588292
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.07046787
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06018251
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.05719916
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05182529
29* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05007950
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99583826
31ZNF274_21170338_ChIP-Seq_K562_Hela1.98884272
32* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96073641
33VDR_23849224_ChIP-Seq_CD4+_Human1.94964875
34FUS_26573619_Chip-Seq_HEK293_Human1.91622856
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90619252
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89731331
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89024277
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.83520226
39SCL_19346495_ChIP-Seq_HPC-7_Human1.79954632
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.78622028
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74097206
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72689712
43VDR_22108803_ChIP-Seq_LS180_Human1.71429036
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65790968
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65753426
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63584497
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59863809
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58919306
49FOXP3_21729870_ChIP-Seq_TREG_Human1.56044865
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.53419524
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49589713
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48927696
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48582792
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48000042
55TAF15_26573619_Chip-Seq_HEK293_Human1.47278239
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.45993246
57AR_21572438_ChIP-Seq_LNCaP_Human1.44067576
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35767780
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34069204
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29498262
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28590448
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.28346565
63* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28240291
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26482157
65GATA1_22025678_ChIP-Seq_K562_Human1.25548619
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.23754850
67EWS_26573619_Chip-Seq_HEK293_Human1.23493531
68* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23147988
69* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23147988
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21226269
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20785404
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18870141
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.18579737
74* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17873736
75DROSHA_22980978_ChIP-Seq_HELA_Human1.17479491
76DCP1A_22483619_ChIP-Seq_HELA_Human1.16881859
77GATA3_26560356_Chip-Seq_TH1_Human1.16850529
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16619757
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16043469
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16043469
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15298493
82CBP_20019798_ChIP-Seq_JUKART_Human1.15298493
83TFEB_21752829_ChIP-Seq_HELA_Human1.14937543
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14261918
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12824622
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12398157
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.12331026
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11494699
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11402568
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.09592092
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08216527
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08168106
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07467744
94ER_23166858_ChIP-Seq_MCF-7_Human1.06976168
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06163078
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05644226
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05315297
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02756478
99BCAT_22108803_ChIP-Seq_LS180_Human1.02535387
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02200820
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01912355
102GABP_19822575_ChIP-Seq_HepG2_Human1.01369406
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00216332
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99511605
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97738979
106TP53_22573176_ChIP-Seq_HFKS_Human0.97165891
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96841977
108GATA1_19941826_ChIP-Seq_K562_Human0.96701348
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.95968560
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95918561
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95809571
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95148465
113CRX_20693478_ChIP-Seq_RETINA_Mouse0.94589606
114TTF2_22483619_ChIP-Seq_HELA_Human0.93866851
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.92754391
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91959879
117ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91754883
118IGF1R_20145208_ChIP-Seq_DFB_Human0.91424757
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91155774
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91140114
121MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90668348
122* SOX2_20726797_ChIP-Seq_SW620_Human0.90431541
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89439991
124HTT_18923047_ChIP-ChIP_STHdh_Human0.89173767
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88879968
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86655319
127P300_19829295_ChIP-Seq_ESCs_Human0.85885167
128SOX2_19829295_ChIP-Seq_ESCs_Human0.85770018
129NANOG_19829295_ChIP-Seq_ESCs_Human0.85770018
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85555465
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84152896
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84085836
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.83308648
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82845707
135RXR_22108803_ChIP-Seq_LS180_Human0.82159689
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81862196
137PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81796332
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81222748
139MYC_18940864_ChIP-ChIP_HL60_Human0.80924503
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80614295
141VDR_24787735_ChIP-Seq_THP-1_Human0.80534599
142CIITA_25753668_ChIP-Seq_RAJI_Human0.80237749
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79892691
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79103739
145RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78869377
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78785813
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78573221
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78537351
149* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78158255
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.78152570
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.78126339
152MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78076262
153HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77920622
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77911746
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.76523703
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.76523703
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76171988
158TAL1_26923725_Chip-Seq_HPCs_Mouse0.76044381
159STAT3_23295773_ChIP-Seq_U87_Human0.75972173
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75160964
161RUNX_20019798_ChIP-Seq_JUKART_Human0.75016104
162NFYB_21822215_ChIP-Seq_K562_Human0.74660284
163GATA2_19941826_ChIP-Seq_K562_Human0.73900656
164SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.72663414
165STAT3_18555785_Chip-Seq_ESCs_Mouse0.72545565
166GATA3_26560356_Chip-Seq_TH2_Human0.72471950
167IRF1_19129219_ChIP-ChIP_H3396_Human0.71074166
168SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.70644824
169PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70564872
170CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70124370
171SUZ12_18555785_Chip-Seq_ESCs_Mouse0.69933344
172SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.69326582
173SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68895468
174NFE2_27457419_Chip-Seq_LIVER_Mouse0.68762634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.03245498
2MP0003303_peritoneal_inflammation5.67452325
3MP0008057_abnormal_DNA_replication3.74794648
4MP0005670_abnormal_white_adipose3.26498074
5MP0010094_abnormal_chromosome_stability3.16103626
6MP0003195_calcinosis2.87024442
7MP0002837_dystrophic_cardiac_calcinosis2.75855426
8MP0000569_abnormal_digit_pigmentation2.48567141
9MP0000920_abnormal_myelination2.48413350
10MP0005058_abnormal_lysosome_morphology2.47175083
11MP0004147_increased_porphyrin_level2.42039051
12MP0008058_abnormal_DNA_repair2.36930154
13MP0003724_increased_susceptibility_to2.33196550
14MP0003077_abnormal_cell_cycle2.29654616
15MP0006036_abnormal_mitochondrial_physio2.21847621
16MP0000749_muscle_degeneration2.20627125
17MP0005365_abnormal_bile_salt2.16158238
18MP0003690_abnormal_glial_cell2.12098891
19MP0000013_abnormal_adipose_tissue2.09582263
20MP0001915_intracranial_hemorrhage2.04867135
21MP0002396_abnormal_hematopoietic_system2.02913043
22MP0009379_abnormal_foot_pigmentation2.01661226
23MP0004130_abnormal_muscle_cell1.91830466
24MP0000751_myopathy1.90584444
25MP0005666_abnormal_adipose_tissue1.89359292
26MP0003950_abnormal_plasma_membrane1.87093312
27MP0004084_abnormal_cardiac_muscle1.83522400
28MP0002876_abnormal_thyroid_physiology1.81603494
29MP0002118_abnormal_lipid_homeostasis1.80203672
30MP0002971_abnormal_brown_adipose1.78996225
31MP0005408_hypopigmentation1.76372750
32MP0002148_abnormal_hypersensitivity_rea1.73458910
33MP0002751_abnormal_autonomic_nervous1.70774224
34MP0000383_abnormal_hair_follicle1.70271834
35MP0003191_abnormal_cellular_cholesterol1.67811898
36MP0005171_absent_coat_pigmentation1.67352208
37MP0004957_abnormal_blastocyst_morpholog1.67301060
38MP0005075_abnormal_melanosome_morpholog1.66884859
39MP0004036_abnormal_muscle_relaxation1.66572925
40MP0005085_abnormal_gallbladder_physiolo1.62234687
41MP0003763_abnormal_thymus_physiology1.61381323
42MP0003937_abnormal_limbs/digits/tail_de1.59691478
43MP0003115_abnormal_respiratory_system1.58091352
44MP0000685_abnormal_immune_system1.56692707
45MP0003646_muscle_fatigue1.54824730
46MP0002139_abnormal_hepatobiliary_system1.52266364
47MP0001663_abnormal_digestive_system1.51262912
48MP0005389_reproductive_system_phenotype1.48056573
49MP0002938_white_spotting1.45900095
50MP0008995_early_reproductive_senescence1.44711088
51MP0001835_abnormal_antigen_presentation1.44190165
52MP0010329_abnormal_lipoprotein_level1.43142315
53MP0005332_abnormal_amino_acid1.42579148
54MP0004185_abnormal_adipocyte_glucose1.42480887
55MP0003693_abnormal_embryo_hatching1.41785906
56MP0005375_adipose_tissue_phenotype1.41244279
57MP0005360_urolithiasis1.38228221
58MP0001666_abnormal_nutrient_absorption1.37073573
59MP0002277_abnormal_respiratory_mucosa1.35457645
60MP0005451_abnormal_body_composition1.34861442
61MP0001919_abnormal_reproductive_system1.34807872
62MP0005584_abnormal_enzyme/coenzyme_acti1.34143986
63MP0000372_irregular_coat_pigmentation1.34112367
64MP0003786_premature_aging1.33215331
65MP0003806_abnormal_nucleotide_metabolis1.32676515
66MP0002019_abnormal_tumor_incidence1.31019244
67MP0006054_spinal_hemorrhage1.30256690
68MP0005535_abnormal_body_temperature1.29717120
69MP0005334_abnormal_fat_pad1.28712490
70MP0000747_muscle_weakness1.27849177
71MP0003111_abnormal_nucleus_morphology1.26306858
72MP0003011_delayed_dark_adaptation1.24386256
73MP0004142_abnormal_muscle_tone1.22155475
74MP0000467_abnormal_esophagus_morphology1.22134391
75MP0001764_abnormal_homeostasis1.21144334
76MP0008932_abnormal_embryonic_tissue1.20513979
77MP0009840_abnormal_foam_cell1.20187753
78MP0004215_abnormal_myocardial_fiber1.20165312
79MP0009643_abnormal_urine_homeostasis1.19009441
80MP0008007_abnormal_cellular_replicative1.16993913
81MP0000230_abnormal_systemic_arterial1.16738277
82MP0005671_abnormal_response_to1.15941976
83MP0001293_anophthalmia1.14008989
84MP0001664_abnormal_digestion1.13719693
85MP0001905_abnormal_dopamine_level1.13236713
86MP0003718_maternal_effect1.12634789
87MP0005025_abnormal_response_to1.09606399
88MP0005076_abnormal_cell_differentiation1.09027908
89MP0001790_abnormal_immune_system1.08693256
90MP0005387_immune_system_phenotype1.08693256
91MP0005253_abnormal_eye_physiology1.08170641
92MP0002078_abnormal_glucose_homeostasis1.08165812
93MP0003252_abnormal_bile_duct1.07923456
94MP0004043_abnormal_pH_regulation1.06739587
95MP0005379_endocrine/exocrine_gland_phen1.06699410
96MP0009785_altered_susceptibility_to1.05579443
97MP0002210_abnormal_sex_determination1.05129017
98MP0005330_cardiomyopathy1.04472580
99MP0000003_abnormal_adipose_tissue1.03979285
100MP0002095_abnormal_skin_pigmentation1.01265404
101MP0000609_abnormal_liver_physiology1.01259744
102MP0008469_abnormal_protein_level1.01117849
103MP0001286_abnormal_eye_development1.00019443
104MP0003186_abnormal_redox_activity0.99700369
105MP0005084_abnormal_gallbladder_morpholo0.96667246
106MP0004510_myositis0.96553704
107MP0005174_abnormal_tail_pigmentation0.96541772
108MP0001986_abnormal_taste_sensitivity0.95287781
109MP0000358_abnormal_cell_content/0.94910063
110MP0009763_increased_sensitivity_to0.94146156
111MP0004484_altered_response_of0.93984392
112MP0004145_abnormal_muscle_electrophysio0.93670715
113MP0008775_abnormal_heart_ventricle0.93630736
114MP0001929_abnormal_gametogenesis0.93434877
115MP0005319_abnormal_enzyme/_coenzyme0.93315469
116MP0006138_congestive_heart_failure0.91760586
117MP0005083_abnormal_biliary_tract0.91261455
118MP0002419_abnormal_innate_immunity0.90832369
119MP0005636_abnormal_mineral_homeostasis0.90293876
120MP0008875_abnormal_xenobiotic_pharmacok0.89908911
121MP0005646_abnormal_pituitary_gland0.89758922
122MP0003656_abnormal_erythrocyte_physiolo0.89334698
123MP0006082_CNS_inflammation0.89322164
124MP0002106_abnormal_muscle_physiology0.88434016
125MP0001661_extended_life_span0.87143590
126MP0004197_abnormal_fetal_growth/weight/0.87129203
127MP0001765_abnormal_ion_homeostasis0.86987254
128MP0005000_abnormal_immune_tolerance0.86515269
129MP0000350_abnormal_cell_proliferation0.86443231
130MP0001119_abnormal_female_reproductive0.86364783
131MP0000313_abnormal_cell_death0.86148684
132MP0000371_diluted_coat_color0.83711971
133MP0003828_pulmonary_edema0.83104577
134MP0001873_stomach_inflammation0.82788967
135MP0002638_abnormal_pupillary_reflex0.82679242
136MP0005448_abnormal_energy_balance0.82431592
137MP0010307_abnormal_tumor_latency0.82263260
138MP0005165_increased_susceptibility_to0.81139744
139MP0010678_abnormal_skin_adnexa0.80959932
140MP0003183_abnormal_peptide_metabolism0.80659450
141MP0003137_abnormal_impulse_conducting0.80461782
142MP0000015_abnormal_ear_pigmentation0.80425224
143MP0005381_digestive/alimentary_phenotyp0.80166547
144MP0005197_abnormal_uvea_morphology0.79555392
145MP0003221_abnormal_cardiomyocyte_apopto0.79523322
146MP0003075_altered_response_to0.79520462
147MP0002723_abnormal_immune_serum0.79247320
148MP0004381_abnormal_hair_follicle0.79192183
149MP0002009_preneoplasia0.78202139
150MP0003868_abnormal_feces_composition0.77531523
151MP0005369_muscle_phenotype0.77462597
152MP0002928_abnormal_bile_duct0.77329145
153MP0003633_abnormal_nervous_system0.77327090
154MP0003136_yellow_coat_color0.77043477
155MP0002229_neurodegeneration0.76271855
156MP0001544_abnormal_cardiovascular_syste0.76040159
157MP0005385_cardiovascular_system_phenoty0.76040159
158MP0002972_abnormal_cardiac_muscle0.75807108
159MP0000604_amyloidosis0.75287844
160MP0005376_homeostasis/metabolism_phenot0.74526075
161MP0002160_abnormal_reproductive_system0.74493153
162MP0009697_abnormal_copulation0.74372441
163MP0005620_abnormal_muscle_contractility0.73139565
164MP0005266_abnormal_metabolism0.71999864
165MP0000428_abnormal_craniofacial_morphol0.71546726
166MP0001145_abnormal_male_reproductive0.70631675
167MP0000653_abnormal_sex_gland0.70572447
168MP0005395_other_phenotype0.70554836
169MP0003984_embryonic_growth_retardation0.69270762
170MP0002088_abnormal_embryonic_growth/wei0.68154034
171MP0002109_abnormal_limb_morphology0.67909397
172MP0005397_hematopoietic_system_phenotyp0.67046856
173MP0001545_abnormal_hematopoietic_system0.67046856
174MP0003935_abnormal_craniofacial_develop0.66654163
175MP0006035_abnormal_mitochondrial_morpho0.64286189
176MP0002405_respiratory_system_inflammati0.63805843
177MP0002132_abnormal_respiratory_system0.62451953
178MP0001324_abnormal_eye_pigmentation0.61510072

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)6.72045841
2Abnormality of the renal collecting system (HP:0004742)5.88064457
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.27361404
4Progressive muscle weakness (HP:0003323)4.93876454
5Chromsome breakage (HP:0040012)4.89983931
6Hypoplastic pelvis (HP:0008839)4.75556918
7Long foot (HP:0001833)4.70751096
8Hepatic necrosis (HP:0002605)4.34764652
9Acute lymphatic leukemia (HP:0006721)4.17215815
10Hepatocellular necrosis (HP:0001404)4.06213243
11Acute necrotizing encephalopathy (HP:0006965)3.94328341
12Mitochondrial inheritance (HP:0001427)3.88473979
13Increased muscle lipid content (HP:0009058)3.85768619
14Abnormal mitochondria in muscle tissue (HP:0008316)3.83876931
15Clubbing of toes (HP:0100760)3.79160935
16Acute encephalopathy (HP:0006846)3.74483147
17Hypoglycemic coma (HP:0001325)3.61672119
18Abnormality of fatty-acid metabolism (HP:0004359)3.56224242
19Increased CSF lactate (HP:0002490)3.55398346
20Chronic hepatic failure (HP:0100626)3.54655201
21Large for gestational age (HP:0001520)3.50924954
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.50464985
23Abnormal hemoglobin (HP:0011902)3.48895762
24Dicarboxylic aciduria (HP:0003215)3.45077199
25Abnormality of dicarboxylic acid metabolism (HP:0010995)3.45077199
26Increased intramyocellular lipid droplets (HP:0012240)3.33335985
27Lipid accumulation in hepatocytes (HP:0006561)3.32017406
28Abnormality of chromosome stability (HP:0003220)3.24202043
29Renal Fanconi syndrome (HP:0001994)3.17442978
30Progressive macrocephaly (HP:0004481)3.14972760
31Ureteral duplication (HP:0000073)3.13450001
32Cerebral edema (HP:0002181)3.11961119
33Generalized aminoaciduria (HP:0002909)3.10319457
34Aplasia/Hypoplasia of the uvula (HP:0010293)3.08075724
35Abnormality of the ileum (HP:0001549)3.05153667
36Meckel diverticulum (HP:0002245)3.00540527
37Methylmalonic acidemia (HP:0002912)2.98026240
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.96589724
39Ketoacidosis (HP:0001993)2.93744986
40Ketosis (HP:0001946)2.92123196
41Myoglobinuria (HP:0002913)2.90345505
42Hypoplastic iliac wings (HP:0002866)2.86148381
43Lactic acidosis (HP:0003128)2.84745646
44Increased serum pyruvate (HP:0003542)2.83680112
45Abnormality of glycolysis (HP:0004366)2.83680112
46Ectopic kidney (HP:0000086)2.82927045
47Increased hepatocellular lipid droplets (HP:0006565)2.82079697
48Steatorrhea (HP:0002570)2.79094785
49Dry hair (HP:0011359)2.78664311
50Ureteral obstruction (HP:0006000)2.74333205
51Adactyly (HP:0009776)2.73859719
52Autoamputation (HP:0001218)2.73381914
53Abnormality of the preputium (HP:0100587)2.70937176
54Exercise-induced myalgia (HP:0003738)2.69848186
55Anhidrosis (HP:0000970)2.67522522
56Ureteral stenosis (HP:0000071)2.65204744
57Abnormal auditory evoked potentials (HP:0006958)2.64845309
583-Methylglutaconic aciduria (HP:0003535)2.61865350
59Methylmalonic aciduria (HP:0012120)2.60991910
60Exercise intolerance (HP:0003546)2.59781733
61Fibular aplasia (HP:0002990)2.59737095
62Respiratory failure (HP:0002878)2.55101398
63Neurofibrillary tangles (HP:0002185)2.55054586
64Rhabdomyolysis (HP:0003201)2.54187524
65Renal cortical cysts (HP:0000803)2.48330062
66Vacuolated lymphocytes (HP:0001922)2.47894163
67Leukodystrophy (HP:0002415)2.44958599
68Small intestinal stenosis (HP:0012848)2.43450943
69Duodenal stenosis (HP:0100867)2.43450943
70Hyperinsulinemic hypoglycemia (HP:0000825)2.42471471
71Aplasia involving forearm bones (HP:0009822)2.41583609
72Absent forearm bone (HP:0003953)2.41583609
73Severe muscular hypotonia (HP:0006829)2.40732365
74Increased number of teeth (HP:0011069)2.38530117
75Hyperammonemia (HP:0001987)2.38205466
76Menstrual irregularities (HP:0000858)2.37009139
77Abnormality of pyrimidine metabolism (HP:0004353)2.36659957
78Nephroblastoma (Wilms tumor) (HP:0002667)2.36249350
79Hyperlipoproteinemia (HP:0010980)2.32553548
80Increased serum lactate (HP:0002151)2.32549688
81Volvulus (HP:0002580)2.31778206
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30518705
83Long clavicles (HP:0000890)2.30315653
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.27709779
85Abnormality of the duodenum (HP:0002246)2.25440103
86Abnormality of urine glucose concentration (HP:0011016)2.25358148
87Glycosuria (HP:0003076)2.25358148
88Cerebral hemorrhage (HP:0001342)2.23880461
89Abnormality of glycine metabolism (HP:0010895)2.22409267
90Abnormality of serine family amino acid metabolism (HP:0010894)2.22409267
91Absent radius (HP:0003974)2.21395476
92Lethargy (HP:0001254)2.17739089
93Metabolic acidosis (HP:0001942)2.17733088
94Neuroendocrine neoplasm (HP:0100634)2.17459634
95Embryonal renal neoplasm (HP:0011794)2.16897695
96Dilated cardiomyopathy (HP:0001644)2.15762412
97Decreased lacrimation (HP:0000633)2.14488747
98Oligodactyly (hands) (HP:0001180)2.12946416
99Sloping forehead (HP:0000340)2.12566254
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11396073
101Ependymoma (HP:0002888)2.10406780
102Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09997394
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09997394
104Axonal loss (HP:0003447)2.09427097
105Abnormality of the heme biosynthetic pathway (HP:0010472)2.09046478
106Short middle phalanx of the 5th finger (HP:0004220)2.08731892
107Myelodysplasia (HP:0002863)2.08412879
108Prolonged partial thromboplastin time (HP:0003645)2.08029615
109Intrahepatic cholestasis (HP:0001406)2.07047378
110Hepatosplenomegaly (HP:0001433)2.06992857
111Vomiting (HP:0002013)2.05842930
112Hyperglycinuria (HP:0003108)2.05430210
113Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04659472
114Pancreatic islet-cell hyperplasia (HP:0004510)2.04429447
115Abnormality of renal resorption (HP:0011038)2.03190707
116Fat malabsorption (HP:0002630)2.02016035
117Abnormality of the carotid arteries (HP:0005344)2.01646518
118Hypothermia (HP:0002045)2.01513049
119Glioma (HP:0009733)2.00873936
120Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99101648
121Palpitations (HP:0001962)1.98666148
122Microvesicular hepatic steatosis (HP:0001414)1.98548283
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97722929
124Poor speech (HP:0002465)1.96205698
125Dyschromatopsia (HP:0007641)1.95765049
126Oligomenorrhea (HP:0000876)1.95506302
127Muscle hypertrophy of the lower extremities (HP:0008968)1.95294802
128Abnormality of vitamin B metabolism (HP:0004340)1.94174598
129Abnormality of methionine metabolism (HP:0010901)1.92171588
130Medulloblastoma (HP:0002885)1.92149809
131Wide intermamillary distance (HP:0006610)1.91937277
132Hypoglycemic seizures (HP:0002173)1.91811325
133Pheochromocytoma (HP:0002666)1.91319842
134Exertional dyspnea (HP:0002875)1.90969482
135Xanthomatosis (HP:0000991)1.90340498
136Calf muscle hypertrophy (HP:0008981)1.89161498
137Abnormality of the intrinsic pathway (HP:0010989)1.88782318
138Hyperalaninemia (HP:0003348)1.88634618
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88634618
140Abnormality of alanine metabolism (HP:0010916)1.88634618
141Hypoplastic nipples (HP:0002557)1.88605491
142Sudden death (HP:0001699)1.87603599
143Increased cerebral lipofuscin (HP:0011813)1.87562629
144Spastic paraparesis (HP:0002313)1.87483461
145Exercise-induced muscle cramps (HP:0003710)1.87304442
146Transposition of the great arteries (HP:0001669)1.86537284
147Abnormal connection of the cardiac segments (HP:0011545)1.86537284
148Abnormal ventriculo-arterial connection (HP:0011563)1.86537284
149Rhabdomyosarcoma (HP:0002859)1.86204452
150Respiratory distress (HP:0002098)1.84961804
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.84721714
152Respiratory difficulties (HP:0002880)1.84707753
153Systemic lupus erythematosus (HP:0002725)1.84617108
154Optic disc pallor (HP:0000543)1.83803643
155Opisthotonus (HP:0002179)1.82866491
156Parakeratosis (HP:0001036)1.82785501
157Asymmetric septal hypertrophy (HP:0001670)1.82739521
158Birth length less than 3rd percentile (HP:0003561)1.82605578
159Abnormality of endocrine pancreas physiology (HP:0012093)1.82601564
160Abnormality of the pancreatic islet cells (HP:0006476)1.82601564
161Abnormal finger flexion creases (HP:0006143)1.81413992
162Albinism (HP:0001022)1.80946668
163Abnormality of serum amino acid levels (HP:0003112)1.80826587
164Muscle stiffness (HP:0003552)1.80039032
165Depressed nasal tip (HP:0000437)1.79087308
166Ventricular tachycardia (HP:0004756)1.78800073
167Brushfield spots (HP:0001088)1.78483490
168Increased IgE level (HP:0003212)1.78196493
169Reduced subcutaneous adipose tissue (HP:0003758)1.77480062
170Abnormality of the astrocytes (HP:0100707)1.77391811
171Astrocytoma (HP:0009592)1.77391811
172Gaze-evoked nystagmus (HP:0000640)1.73698338
173CNS demyelination (HP:0007305)1.72439708
174Limb hypertonia (HP:0002509)1.70897788
175Polyneuropathy (HP:0001271)1.70400886
176Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.69691901
177Female pseudohermaphroditism (HP:0010458)1.69425659
178Abnormal lung lobation (HP:0002101)1.67981010
179Abnormality of the pubic bones (HP:0003172)1.67562662
180Constricted visual fields (HP:0001133)1.65702759
181Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.65357704
182Decreased muscle mass (HP:0003199)1.63813254
183Abnormality of the labia minora (HP:0012880)1.60847711
184Hypergonadotropic hypogonadism (HP:0000815)1.60767848
185Broad-based gait (HP:0002136)1.59998877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.45856100
2TAOK13.84502599
3TAOK23.61512586
4STK393.61500055
5BCKDK3.38651005
6MAP2K33.09111668
7EPHB12.96862059
8MUSK2.72994155
9MAP3K32.51292789
10OXSR12.45524070
11TNIK2.34502807
12INSRR2.25542733
13SRPK12.16534762
14MKNK210.4149089
15FRK1.97554902
16WNK41.87357672
17MAPK151.86978940
18EIF2AK31.86707706
19TIE11.83831819
20BMPR1B1.78155319
21CDK191.77649596
22MAPKAPK51.71891901
23MAP3K111.71605276
24PKN11.68204668
25PRPF4B1.67274225
26OBSCN1.67082359
27PHKG11.59811183
28PHKG21.59811183
29IRAK41.52698387
30MAP3K141.52331192
31BRD41.50021990
32MET1.48202540
33BUB11.47201668
34ACVR1B1.46645178
35GRK71.45493124
36BLK1.45208966
37TYK21.43436420
38MYLK1.42102725
39LMTK21.36408949
40PASK1.36043220
41TGFBR21.32754213
42PINK11.32651523
43PLK41.31826587
44STK161.28470756
45MAP3K101.25677404
46ABL21.24836078
47PRKCQ1.24144766
48NEK91.23684046
49FGR1.20808592
50BCR1.18874993
51PIK3CG1.16576532
52NME11.16255818
53DYRK1A1.15859740
54TXK1.14643106
55TBK11.13797802
56CDC71.13628427
57BRSK21.12950751
58PBK1.12142641
59CAMK2D1.10580965
60JAK11.10576441
61EIF2AK11.08606465
62PNCK1.07119588
63EPHA31.06448307
64FGFR41.06179269
65IRAK31.05546203
66IKBKE1.05053536
67TTN1.04221037
68ERBB31.03437020
69KIT1.00996665
70BMPR20.97045628
71CHEK20.96371429
72ERN10.95099724
73WEE10.94011523
74TAOK30.93874655
75CLK10.93405834
76MARK30.92846158
77MAP4K10.91640204
78ZAK0.91532323
79ARAF0.88137047
80IRAK10.87901545
81CASK0.87257125
82NLK0.87157880
83PRKAA20.85773069
84PRKCE0.84753981
85WNK10.83805427
86PDK30.83595520
87PDK40.83595520
88CAMK1G0.81227705
89DYRK30.80078608
90SYK0.79448247
91NUAK10.76201068
92TNK20.76189724
93CSNK1G10.73955848
94MAP3K50.73129054
95CSF1R0.72927326
96BTK0.72077527
97MAP3K130.70671505
98RPS6KA50.70434803
99CSNK1G30.69886525
100NEK10.69380731
101MAP3K120.68641859
102CAMK2G0.68123368
103TEC0.68005362
104CAMK2B0.67206185
105MAP3K40.64415306
106ATR0.63417593
107PRKD10.63219271
108FLT30.63169272
109LCK0.63142539
110HIPK20.62542108
111TRPM70.62162032
112MAP3K10.62063845
113IRAK20.61101572
114PDK20.60367639
115CSNK1A1L0.60301793
116ADRBK20.59656090
117ITK0.56140396
118JAK30.55458330
119WNK30.53735268
120JAK20.53379191
121CCNB10.53117637
122VRK10.53046132
123SGK2230.49660302
124SGK4940.49660302
125PRKCH0.48887978
126MAP3K70.46653825
127PTK2B0.46592979
128SGK20.44804035
129CAMK2A0.44677775
130IKBKB0.43762160
131MST1R0.43680330
132PRKACA0.43184401
133MST40.41359698
134GRK10.40871931
135CAMK1D0.39773500
136ROCK20.39159979
137MAP3K60.38447826
138MAP3K80.38206081
139GRK50.38084920
140PRKG10.37821153
141AKT30.36447018
142MAP2K10.36200076
143TLK10.30160579
144ATM0.29288352
145EIF2AK20.29174712
146PLK10.28499962
147CHEK10.26335489
148PLK30.25964210
149YES10.25283841
150RIPK40.24567038
151ABL10.24352815
152CSNK2A20.23077661
153AURKB0.21379286
154SGK10.21317642
155CDK120.19426135
156FGFR10.19318176
157ERBB40.18136538
158IGF1R0.17612374
159MAP4K20.17287687
160SGK30.16917996
161RAF10.15557165
162CSNK2A10.15016258
163STK40.14998896
164PAK30.14039747
165CDK10.13477223
166TTK0.13458274
167MAPK130.11732139
168CDK20.11025508
169PIM10.10680315

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.77959839
2Oxidative phosphorylation_Homo sapiens_hsa001903.12584846
3Propanoate metabolism_Homo sapiens_hsa006403.12195930
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.97082460
5Fatty acid degradation_Homo sapiens_hsa000712.93228884
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.86632950
7Fatty acid metabolism_Homo sapiens_hsa012122.86280104
8RNA polymerase_Homo sapiens_hsa030202.83683673
9One carbon pool by folate_Homo sapiens_hsa006702.67621626
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66198119
11Parkinsons disease_Homo sapiens_hsa050122.53388060
12Protein export_Homo sapiens_hsa030602.51918565
13Homologous recombination_Homo sapiens_hsa034402.35486705
14Mismatch repair_Homo sapiens_hsa034302.31190622
15Fanconi anemia pathway_Homo sapiens_hsa034602.24865131
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23253621
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22118773
18Non-homologous end-joining_Homo sapiens_hsa034502.20502157
19Alzheimers disease_Homo sapiens_hsa050102.10739852
20Peroxisome_Homo sapiens_hsa041462.00711367
21PPAR signaling pathway_Homo sapiens_hsa033201.99646540
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97699438
23Sulfur metabolism_Homo sapiens_hsa009201.97279113
24Proteasome_Homo sapiens_hsa030501.97272638
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93925088
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91750712
27Lysine degradation_Homo sapiens_hsa003101.88297076
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87606550
29RNA transport_Homo sapiens_hsa030131.86697973
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.84812598
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81228069
32DNA replication_Homo sapiens_hsa030301.75449526
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68457919
34Pyruvate metabolism_Homo sapiens_hsa006201.66928473
35Butanoate metabolism_Homo sapiens_hsa006501.64805841
36Histidine metabolism_Homo sapiens_hsa003401.58541627
37Taste transduction_Homo sapiens_hsa047421.56903219
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55087791
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.48440462
40Basal transcription factors_Homo sapiens_hsa030221.46598936
41Nucleotide excision repair_Homo sapiens_hsa034201.44630525
42Steroid biosynthesis_Homo sapiens_hsa001001.42792607
43RNA degradation_Homo sapiens_hsa030181.42083710
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36381907
45Huntingtons disease_Homo sapiens_hsa050161.36157948
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30414173
47Tryptophan metabolism_Homo sapiens_hsa003801.23575427
48Carbon metabolism_Homo sapiens_hsa012001.21415558
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19144084
50ABC transporters_Homo sapiens_hsa020101.15827261
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15435998
52Cell cycle_Homo sapiens_hsa041101.14596583
53Arachidonic acid metabolism_Homo sapiens_hsa005901.14480822
54Linoleic acid metabolism_Homo sapiens_hsa005911.14319594
55Ether lipid metabolism_Homo sapiens_hsa005651.11249196
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06780267
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05473080
58Cardiac muscle contraction_Homo sapiens_hsa042601.02679635
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02651257
60Pyrimidine metabolism_Homo sapiens_hsa002401.02181239
61Staphylococcus aureus infection_Homo sapiens_hsa051501.01409536
62beta-Alanine metabolism_Homo sapiens_hsa004100.97567541
63Folate biosynthesis_Homo sapiens_hsa007900.97294901
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96764035
65p53 signaling pathway_Homo sapiens_hsa041150.94947354
66Fatty acid biosynthesis_Homo sapiens_hsa000610.93041626
67Purine metabolism_Homo sapiens_hsa002300.92162934
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89257718
69Spliceosome_Homo sapiens_hsa030400.88358576
70Lysosome_Homo sapiens_hsa041420.86975713
71Other glycan degradation_Homo sapiens_hsa005110.86352256
72Starch and sucrose metabolism_Homo sapiens_hsa005000.85325079
73Glycerolipid metabolism_Homo sapiens_hsa005610.84870184
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83532781
75mRNA surveillance pathway_Homo sapiens_hsa030150.82419485
76Sphingolipid metabolism_Homo sapiens_hsa006000.81676825
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81621835
78Metabolic pathways_Homo sapiens_hsa011000.81507007
79Phenylalanine metabolism_Homo sapiens_hsa003600.80877151
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80851954
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74095040
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.73171165
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.72746938
84Epstein-Barr virus infection_Homo sapiens_hsa051690.72671373
85Vitamin B6 metabolism_Homo sapiens_hsa007500.71682695
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70867242
87Complement and coagulation cascades_Homo sapiens_hsa046100.70644802
88Tyrosine metabolism_Homo sapiens_hsa003500.70566742
89Systemic lupus erythematosus_Homo sapiens_hsa053220.68065209
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67076571
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64331566
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59580574
93Fat digestion and absorption_Homo sapiens_hsa049750.56258524
94Ribosome_Homo sapiens_hsa030100.55676806
95Arginine and proline metabolism_Homo sapiens_hsa003300.54739160
96Vitamin digestion and absorption_Homo sapiens_hsa049770.53783887
97Arginine biosynthesis_Homo sapiens_hsa002200.53039500
98Measles_Homo sapiens_hsa051620.51716960
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.51136741
100Rheumatoid arthritis_Homo sapiens_hsa053230.50448517
101Glutathione metabolism_Homo sapiens_hsa004800.49893809
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49290427
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48530804
104Chemical carcinogenesis_Homo sapiens_hsa052040.47802349
105Vibrio cholerae infection_Homo sapiens_hsa051100.47769123
106Retinol metabolism_Homo sapiens_hsa008300.44381465
107Caffeine metabolism_Homo sapiens_hsa002320.44368059
108Selenocompound metabolism_Homo sapiens_hsa004500.43587371
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.43425601
110Fructose and mannose metabolism_Homo sapiens_hsa000510.42667216
111Collecting duct acid secretion_Homo sapiens_hsa049660.41078636
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39750515
113MicroRNAs in cancer_Homo sapiens_hsa052060.39600351
114Regulation of autophagy_Homo sapiens_hsa041400.37028347
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.36719921
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.36674804
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36626926
118Olfactory transduction_Homo sapiens_hsa047400.36323154
119Prostate cancer_Homo sapiens_hsa052150.35317785
120Oocyte meiosis_Homo sapiens_hsa041140.35057332
121TGF-beta signaling pathway_Homo sapiens_hsa043500.34476710
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.33722998
123Circadian rhythm_Homo sapiens_hsa047100.33346167
124Biosynthesis of amino acids_Homo sapiens_hsa012300.29679655
125Mineral absorption_Homo sapiens_hsa049780.29428584
126Pentose phosphate pathway_Homo sapiens_hsa000300.28528438
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.28510237
128Primary immunodeficiency_Homo sapiens_hsa053400.28031754
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27586531
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27026356
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26738599
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.26724855
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25511859
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25295718
135Malaria_Homo sapiens_hsa051440.25193258
136Legionellosis_Homo sapiens_hsa051340.23390705
137Colorectal cancer_Homo sapiens_hsa052100.22878563
138Base excision repair_Homo sapiens_hsa034100.22758463
139Insulin resistance_Homo sapiens_hsa049310.22236007
140Phagosome_Homo sapiens_hsa041450.22217859
141Galactose metabolism_Homo sapiens_hsa000520.20230054
142Serotonergic synapse_Homo sapiens_hsa047260.20073779
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19305907
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17659910
145African trypanosomiasis_Homo sapiens_hsa051430.16696430
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.16262714
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14364885

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