NUDT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.46810626
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.40704487
3vocalization behavior (GO:0071625)5.20840267
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18352128
5locomotory exploration behavior (GO:0035641)4.79561190
6synaptic vesicle exocytosis (GO:0016079)4.79264520
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68612559
8protein localization to synapse (GO:0035418)4.53184977
9regulation of glutamate receptor signaling pathway (GO:1900449)4.48636248
10exploration behavior (GO:0035640)4.33604174
11neuron recognition (GO:0008038)4.33461097
12regulation of synaptic vesicle exocytosis (GO:2000300)4.31501984
13layer formation in cerebral cortex (GO:0021819)4.30219859
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.28129917
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.26745758
16synaptic vesicle maturation (GO:0016188)4.13134235
17glutamate secretion (GO:0014047)4.09392725
18glutamate receptor signaling pathway (GO:0007215)4.01114897
19transmission of nerve impulse (GO:0019226)3.96368328
20axonal fasciculation (GO:0007413)3.96014975
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95603789
22dendritic spine morphogenesis (GO:0060997)3.91072938
23neurotransmitter secretion (GO:0007269)3.88938416
24neuronal action potential propagation (GO:0019227)3.85136059
25regulation of synaptic vesicle transport (GO:1902803)3.83987194
26regulation of synapse structural plasticity (GO:0051823)3.73481446
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72492765
28neuron-neuron synaptic transmission (GO:0007270)3.70468717
29regulation of neuronal synaptic plasticity (GO:0048168)3.68767240
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66570128
31synaptic transmission, glutamatergic (GO:0035249)3.63657407
32DNA double-strand break processing (GO:0000729)3.55355143
33positive regulation of synapse assembly (GO:0051965)3.49484752
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47576947
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.46858247
36establishment of mitochondrion localization (GO:0051654)3.44029886
37postsynaptic membrane organization (GO:0001941)3.43464807
38regulation of vesicle fusion (GO:0031338)3.42286029
39regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.38007190
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37405976
41pyrimidine nucleobase catabolic process (GO:0006208)3.36202997
42regulation of postsynaptic membrane potential (GO:0060078)3.34956327
43neurotransmitter transport (GO:0006836)3.33276010
44positive regulation of synapse maturation (GO:0090129)3.33239414
45negative regulation of microtubule polymerization (GO:0031115)3.29276710
46long-term memory (GO:0007616)3.27575080
47cell migration in hindbrain (GO:0021535)3.25580979
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21411160
49presynaptic membrane assembly (GO:0097105)3.20023062
50regulation of dendritic spine morphogenesis (GO:0061001)3.19906440
51mating behavior (GO:0007617)3.19840046
52gamma-aminobutyric acid transport (GO:0015812)3.19571976
53synaptic vesicle endocytosis (GO:0048488)3.18529479
54response to histamine (GO:0034776)3.17929432
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.17726925
56proline transport (GO:0015824)3.16217310
57synapse assembly (GO:0007416)3.14396744
58dendrite morphogenesis (GO:0048813)3.13918660
59DNA damage response, detection of DNA damage (GO:0042769)3.12910082
60innervation (GO:0060384)3.12788575
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12261440
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.08113011
63chromatin remodeling at centromere (GO:0031055)3.07154675
64regulation of development, heterochronic (GO:0040034)3.05215322
65behavioral fear response (GO:0001662)3.00823444
66behavioral defense response (GO:0002209)3.00823444
67membrane hyperpolarization (GO:0060081)3.00293040
68regulation of neurotransmitter levels (GO:0001505)3.00124123
69regulation of synapse assembly (GO:0051963)2.99660757
70positive regulation of membrane potential (GO:0045838)2.99600574
71long-term synaptic potentiation (GO:0060291)2.98832330
72central nervous system projection neuron axonogenesis (GO:0021952)2.98049637
73positive regulation of dendritic spine morphogenesis (GO:0061003)2.98027094
74cerebellar Purkinje cell differentiation (GO:0021702)2.98015885
75intraspecies interaction between organisms (GO:0051703)2.97411446
76social behavior (GO:0035176)2.97411446
77regulation of glutamate secretion (GO:0014048)2.97014420
78startle response (GO:0001964)2.96657408
79regulation of synaptic plasticity (GO:0048167)2.96628605
80limb bud formation (GO:0060174)2.95793045
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95641699
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95118449
83neurotransmitter-gated ion channel clustering (GO:0072578)2.94583926
84dendrite development (GO:0016358)2.93771050
85auditory behavior (GO:0031223)2.91981704
86positive regulation of dendritic spine development (GO:0060999)2.91405716
87regulation of respiratory system process (GO:0044065)2.91062095
88learning (GO:0007612)2.90556411
89presynaptic membrane organization (GO:0097090)2.89534421
90fear response (GO:0042596)2.88125144
91positive regulation of mitochondrial fission (GO:0090141)2.88000674
92detection of calcium ion (GO:0005513)2.87909933
93CENP-A containing nucleosome assembly (GO:0034080)2.87468284
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86442196
95synapse organization (GO:0050808)2.86172517
96membrane depolarization (GO:0051899)2.85928040
97DNA ligation (GO:0006266)2.84057796
98righting reflex (GO:0060013)2.83730476
99somite development (GO:0061053)2.83048642
100cullin deneddylation (GO:0010388)2.82939346
101regulation of synaptic transmission, GABAergic (GO:0032228)2.82831301
102negative regulation of DNA recombination (GO:0045910)2.82634642
103regulation of neurotransmitter secretion (GO:0046928)2.81725580
104microtubule depolymerization (GO:0007019)2.81428834
105activation of protein kinase A activity (GO:0034199)2.81266547
106regulation of synapse organization (GO:0050807)2.80102797
107nucleobase catabolic process (GO:0046113)2.79712678
108neuromuscular process controlling posture (GO:0050884)2.79030985
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78481672
110nonmotile primary cilium assembly (GO:0035058)2.78143291
111synaptic transmission (GO:0007268)2.77535247
112organelle transport along microtubule (GO:0072384)2.77494617
113regulation of calcium ion-dependent exocytosis (GO:0017158)2.77334068
114positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75128927
115histone H2A acetylation (GO:0043968)2.67632164
116regulation of timing of cell differentiation (GO:0048505)2.64219121
117sequestering of actin monomers (GO:0042989)2.62577016
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62528514
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.62528514
120regulation of meiosis I (GO:0060631)2.61028252
121cerebral cortex radially oriented cell migration (GO:0021799)2.58866111
122behavioral response to nicotine (GO:0035095)2.56923769
123histone exchange (GO:0043486)2.56892821
124olfactory bulb development (GO:0021772)2.56669269
125hippocampus development (GO:0021766)2.56622793
126establishment of integrated proviral latency (GO:0075713)2.55962418
127protein localization to kinetochore (GO:0034501)2.53836015
128protein deneddylation (GO:0000338)2.53625455
129negative regulation of oligodendrocyte differentiation (GO:0048715)2.49132615
130protein localization to cilium (GO:0061512)2.45855962
131mitochondrion transport along microtubule (GO:0047497)2.45704876
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45704876
133intraciliary transport (GO:0042073)2.45608169
134neurofilament cytoskeleton organization (GO:0060052)2.45572471
135regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.40847282
136resolution of meiotic recombination intermediates (GO:0000712)2.39785014
137retinal ganglion cell axon guidance (GO:0031290)2.39177997
138neural tube formation (GO:0001841)2.38868993
139DNA replication-independent nucleosome assembly (GO:0006336)2.36406507
140DNA replication-independent nucleosome organization (GO:0034724)2.36406507
141spinal cord development (GO:0021510)2.34702593
142calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.34435995
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33971747
144forebrain neuron differentiation (GO:0021879)2.33914051
145short-term memory (GO:0007614)2.33547789
146microtubule polymerization or depolymerization (GO:0031109)2.32017895
147chaperone-mediated protein transport (GO:0072321)2.31168725
148anterograde axon cargo transport (GO:0008089)2.29108776
149protein-cofactor linkage (GO:0018065)2.29066136
150protein polyglutamylation (GO:0018095)2.28173192
151peptidyl-arginine methylation (GO:0018216)2.26267387
152peptidyl-arginine N-methylation (GO:0035246)2.26267387
153cerebral cortex cell migration (GO:0021795)2.22826651
154protein neddylation (GO:0045116)2.21755671
155substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.20497936
156substrate-independent telencephalic tangential migration (GO:0021826)2.20497936
157cerebral cortex neuron differentiation (GO:0021895)2.19825827
158DNA integration (GO:0015074)2.18219986
159negative regulation of transcription regulatory region DNA binding (GO:2000678)2.16377527
160neuron migration (GO:0001764)2.16233108
161protein localization to chromosome (GO:0034502)2.16021577
162regulation of telomere maintenance (GO:0032204)2.16002701
163mechanosensory behavior (GO:0007638)2.15907100
164spindle checkpoint (GO:0031577)2.15792298
165head development (GO:0060322)2.15357348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.57763926
2GBX2_23144817_ChIP-Seq_PC3_Human3.48784163
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11679415
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07216123
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94959382
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.75846448
7REST_21632747_ChIP-Seq_MESCs_Mouse2.65180980
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61299512
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60028684
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60028684
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59795413
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55954311
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52287341
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50707638
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48857334
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48664758
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47566633
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.40235080
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35571513
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34916720
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.29593001
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.25642526
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24981749
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22965295
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20759468
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19639920
27TAF15_26573619_Chip-Seq_HEK293_Human2.18994388
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.17403655
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16292948
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.13464655
31RARB_27405468_Chip-Seq_BRAIN_Mouse2.03579056
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03348258
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99493377
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99306169
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96569289
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95751951
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.94432802
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94273936
39DROSHA_22980978_ChIP-Seq_HELA_Human1.93732422
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93065525
41EWS_26573619_Chip-Seq_HEK293_Human1.89383735
42ZNF274_21170338_ChIP-Seq_K562_Hela1.88383839
43IGF1R_20145208_ChIP-Seq_DFB_Human1.86927797
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86214240
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81857199
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.78834196
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.77285723
48AR_21572438_ChIP-Seq_LNCaP_Human1.73331697
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.68858918
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62866529
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62690971
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62456304
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.61111767
54SMAD4_21799915_ChIP-Seq_A2780_Human1.60902457
55RNF2_27304074_Chip-Seq_NSC_Mouse1.59182173
56P300_19829295_ChIP-Seq_ESCs_Human1.58755026
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57214647
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51103538
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.48794254
60FUS_26573619_Chip-Seq_HEK293_Human1.48174662
61IRF1_19129219_ChIP-ChIP_H3396_Human1.47003383
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46880404
63* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46762253
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44178385
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41600516
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40806746
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40325534
68MYC_18940864_ChIP-ChIP_HL60_Human1.40249274
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39149038
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36624014
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.35665800
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.34956034
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34955741
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.34680762
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.33402344
76ELK1_19687146_ChIP-ChIP_HELA_Human1.32639189
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32159648
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31420100
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31114375
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30781603
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.30739037
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29822128
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29528329
84VDR_22108803_ChIP-Seq_LS180_Human1.29119649
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27458551
86AR_25329375_ChIP-Seq_VCAP_Human1.26454948
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26181568
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24867036
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.23942863
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.21147105
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19222821
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18183587
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.17384686
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16906236
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15481633
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.15346881
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15299965
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14670803
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12883349
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12771399
101STAT3_23295773_ChIP-Seq_U87_Human1.10926905
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09826459
103AR_19668381_ChIP-Seq_PC3_Human1.09168636
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09127671
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.08150473
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.06688135
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03339974
108SOX9_26525672_Chip-Seq_HEART_Mouse1.03221029
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03122180
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02733808
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02643653
112TCF4_23295773_ChIP-Seq_U87_Human1.02103469
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00831905
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00576146
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00553882
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99909318
117TP63_19390658_ChIP-ChIP_HaCaT_Human0.99040443
118JUN_21703547_ChIP-Seq_K562_Human0.98927190
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97585306
120ER_23166858_ChIP-Seq_MCF-7_Human0.97351417
121VDR_23849224_ChIP-Seq_CD4+_Human0.97202161
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96124792
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96120082
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95988951
125CBP_20019798_ChIP-Seq_JUKART_Human0.95007168
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95007168
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94263754
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94263754
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.92763159
130GABP_19822575_ChIP-Seq_HepG2_Human0.92720308
131TTF2_22483619_ChIP-Seq_HELA_Human0.92419122
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92016276
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91913952
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91880092
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91090034
136E2F7_22180533_ChIP-Seq_HELA_Human0.90490774
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90208478
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89458447
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89403168
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89316696
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89111605
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.88949402
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88890910
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.88774832
145BCAT_22108803_ChIP-Seq_LS180_Human0.88740628
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.88538077
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.85719041
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84973566
149DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84811303
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84714849
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84386707
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82445304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.76740962
2MP0003880_abnormal_central_pattern4.70404244
3MP0003635_abnormal_synaptic_transmissio3.64404854
4MP0004270_analgesia3.36315891
5MP0009745_abnormal_behavioral_response3.03019150
6MP0002063_abnormal_learning/memory/cond2.99701720
7MP0006276_abnormal_autonomic_nervous2.85915867
8MP0002064_seizures2.76208507
9MP0002572_abnormal_emotion/affect_behav2.67382554
10MP0001968_abnormal_touch/_nociception2.67013434
11MP0005423_abnormal_somatic_nervous2.64228427
12MP0009046_muscle_twitch2.63174078
13MP0003122_maternal_imprinting2.62389210
14MP0001440_abnormal_grooming_behavior2.57627475
15MP0002734_abnormal_mechanical_nocicepti2.52507981
16MP0005645_abnormal_hypothalamus_physiol2.51692793
17MP0002272_abnormal_nervous_system2.35211444
18MP0001486_abnormal_startle_reflex2.35040542
19MP0008877_abnormal_DNA_methylation2.30767713
20MP0001501_abnormal_sleep_pattern2.25294073
21MP0008789_abnormal_olfactory_epithelium2.25122125
22MP0002733_abnormal_thermal_nociception2.20872989
23MP0001529_abnormal_vocalization2.15698010
24MP0002735_abnormal_chemical_nociception2.14046489
25MP0000778_abnormal_nervous_system2.13055583
26MP0002184_abnormal_innervation2.10146319
27MP0002736_abnormal_nociception_after1.97828819
28MP0001970_abnormal_pain_threshold1.92033774
29MP0008058_abnormal_DNA_repair1.90381544
30MP0002557_abnormal_social/conspecific_i1.88682995
31MP0000049_abnormal_middle_ear1.88032528
32MP0002067_abnormal_sensory_capabilities1.87970865
33MP0002822_catalepsy1.79416987
34MP0005386_behavior/neurological_phenoty1.74082612
35MP0004924_abnormal_behavior1.74082612
36MP0002909_abnormal_adrenal_gland1.73282057
37MP0003329_amyloid_beta_deposits1.65935612
38MP0003890_abnormal_embryonic-extraembry1.64502760
39MP0001905_abnormal_dopamine_level1.59853016
40MP0000955_abnormal_spinal_cord1.55665556
41MP0002837_dystrophic_cardiac_calcinosis1.55444736
42MP0004811_abnormal_neuron_physiology1.51911297
43MP0002233_abnormal_nose_morphology1.49581593
44MP0004142_abnormal_muscle_tone1.49226053
45MP0002653_abnormal_ependyma_morphology1.49043875
46MP0001984_abnormal_olfaction1.45374666
47MP0002234_abnormal_pharynx_morphology1.44494315
48MP0010386_abnormal_urinary_bladder1.44241164
49MP0001293_anophthalmia1.42920521
50MP0002882_abnormal_neuron_morphology1.41566492
51MP0001502_abnormal_circadian_rhythm1.38564396
52MP0004885_abnormal_endolymph1.38431133
53MP0003937_abnormal_limbs/digits/tail_de1.37758041
54MP0004858_abnormal_nervous_system1.37729712
55MP0002066_abnormal_motor_capabilities/c1.35229263
56MP0003787_abnormal_imprinting1.32950825
57MP0002638_abnormal_pupillary_reflex1.31409474
58MP0003121_genomic_imprinting1.29211449
59MP0000566_synostosis1.28324414
60MP0001188_hyperpigmentation1.27698475
61MP0005646_abnormal_pituitary_gland1.27270435
62MP0003567_abnormal_fetal_cardiomyocyte1.26976910
63MP0006072_abnormal_retinal_apoptosis1.26145545
64MP0010094_abnormal_chromosome_stability1.25895954
65MP0000631_abnormal_neuroendocrine_gland1.25244879
66MP0003693_abnormal_embryo_hatching1.24295631
67MP0000013_abnormal_adipose_tissue1.22881789
68MP0004742_abnormal_vestibular_system1.22244035
69MP0003938_abnormal_ear_development1.21932747
70MP0008932_abnormal_embryonic_tissue1.20694991
71MP0002152_abnormal_brain_morphology1.19761520
72MP0008569_lethality_at_weaning1.19346674
73MP0009780_abnormal_chondrocyte_physiolo1.15832132
74MP0004145_abnormal_muscle_electrophysio1.15696243
75MP0005379_endocrine/exocrine_gland_phen1.13163665
76MP0003879_abnormal_hair_cell1.10507372
77MP0003183_abnormal_peptide_metabolism1.07562756
78MP0003123_paternal_imprinting1.07427061
79MP0003755_abnormal_palate_morphology1.06985796
80MP0002938_white_spotting1.05266008
81MP0002697_abnormal_eye_size1.04667711
82MP0008995_early_reproductive_senescence1.02958500
83MP0005551_abnormal_eye_electrophysiolog0.97035419
84MP0002069_abnormal_eating/drinking_beha0.96278595
85MP0002163_abnormal_gland_morphology0.93649667
86MP0001286_abnormal_eye_development0.91907116
87MP0002752_abnormal_somatic_nervous0.91460141
88MP0003111_abnormal_nucleus_morphology0.90904212
89MP0003385_abnormal_body_wall0.90199106
90MP0010030_abnormal_orbit_morphology0.89022228
91MP0000751_myopathy0.88191077
92MP0001963_abnormal_hearing_physiology0.87462601
93MP0003077_abnormal_cell_cycle0.86973647
94MP0002751_abnormal_autonomic_nervous0.86708680
95MP0005187_abnormal_penis_morphology0.86589932
96MP0004085_abnormal_heartbeat0.86520769
97MP0002210_abnormal_sex_determination0.86503578
98MP0002229_neurodegeneration0.86122701
99MP0005391_vision/eye_phenotype0.85505565
100MP0003633_abnormal_nervous_system0.83176443
101MP0003718_maternal_effect0.82538955
102MP0003137_abnormal_impulse_conducting0.82256671
103MP0002081_perinatal_lethality0.82216624
104MP0003861_abnormal_nervous_system0.81945220
105MP0002876_abnormal_thyroid_physiology0.81431119
106MP0003136_yellow_coat_color0.81313819
107MP0004197_abnormal_fetal_growth/weight/0.80418398
108MP0000647_abnormal_sebaceous_gland0.79246199
109MP0003698_abnormal_male_reproductive0.79027504
110MP0001485_abnormal_pinna_reflex0.78977009
111MP0003935_abnormal_craniofacial_develop0.78283696
112MP0003634_abnormal_glial_cell0.76818740
113MP0003631_nervous_system_phenotype0.76171398
114MP0004957_abnormal_blastocyst_morpholog0.75776873
115MP0002282_abnormal_trachea_morphology0.74963701
116MP0008872_abnormal_physiological_respon0.74840037
117MP0005394_taste/olfaction_phenotype0.74828246
118MP0005499_abnormal_olfactory_system0.74828246
119MP0000026_abnormal_inner_ear0.74516542
120MP0001299_abnormal_eye_distance/0.73502141
121MP0002102_abnormal_ear_morphology0.72880713
122MP0003283_abnormal_digestive_organ0.70838111
123MP0004233_abnormal_muscle_weight0.70713674
124MP0001664_abnormal_digestion0.70026690
125MP0005535_abnormal_body_temperature0.67853890
126MP0006292_abnormal_olfactory_placode0.66902970
127MP0000569_abnormal_digit_pigmentation0.65060188
128MP0003959_abnormal_lean_body0.62884306
129MP0001943_abnormal_respiration0.62632493
130MP0001177_atelectasis0.62123583
131MP0003632_abnormal_nervous_system0.60897127
132MP0000537_abnormal_urethra_morphology0.60846415
133MP0005253_abnormal_eye_physiology0.60444054
134MP0004215_abnormal_myocardial_fiber0.59802467
135MP0004133_heterotaxia0.59713186
136MP0003119_abnormal_digestive_system0.58409310
137MP0000604_amyloidosis0.55878955

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.93657207
2Myokymia (HP:0002411)5.42595698
3Focal seizures (HP:0007359)5.09539715
4Visual hallucinations (HP:0002367)4.67798876
5Atonic seizures (HP:0010819)4.34448341
6Epileptic encephalopathy (HP:0200134)4.25489851
7Febrile seizures (HP:0002373)3.94755469
8Absence seizures (HP:0002121)3.93968920
9Cortical dysplasia (HP:0002539)3.70455117
10Dialeptic seizures (HP:0011146)3.54902864
11Generalized tonic-clonic seizures (HP:0002069)3.51402776
12Progressive cerebellar ataxia (HP:0002073)3.41323088
13Hyperventilation (HP:0002883)3.28838664
14Limb dystonia (HP:0002451)3.21201163
15Broad-based gait (HP:0002136)3.16655267
16Supranuclear gaze palsy (HP:0000605)3.12483612
17Amblyopia (HP:0000646)3.01174366
18Colon cancer (HP:0003003)2.96150631
19Excessive salivation (HP:0003781)2.94155550
20Drooling (HP:0002307)2.94155550
21Polyphagia (HP:0002591)2.89847087
22Hemiparesis (HP:0001269)2.89165082
23Agitation (HP:0000713)2.88278737
24Cerebral inclusion bodies (HP:0100314)2.87301559
25Pheochromocytoma (HP:0002666)2.84779873
26Neurofibrillary tangles (HP:0002185)2.80657402
27Ankle clonus (HP:0011448)2.78808801
28Epileptiform EEG discharges (HP:0011182)2.76900368
29Progressive inability to walk (HP:0002505)2.72621039
30Truncal ataxia (HP:0002078)2.72310627
31EEG with generalized epileptiform discharges (HP:0011198)2.71736831
32Shoulder girdle muscle weakness (HP:0003547)2.69508060
33Anxiety (HP:0000739)2.68296432
34Mutism (HP:0002300)2.65480971
35Depression (HP:0000716)2.61431234
36Abnormal eating behavior (HP:0100738)2.59438526
37Hypsarrhythmia (HP:0002521)2.57386923
38Failure to thrive in infancy (HP:0001531)2.55951297
39Poor eye contact (HP:0000817)2.55184406
40Gait imbalance (HP:0002141)2.52841814
41Dysdiadochokinesis (HP:0002075)2.52182782
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46432806
43Neuroendocrine neoplasm (HP:0100634)2.45137127
44Action tremor (HP:0002345)2.41182220
45Papilledema (HP:0001085)2.40846542
46Abnormal social behavior (HP:0012433)2.33963676
47Impaired social interactions (HP:0000735)2.33963676
48Impaired vibration sensation in the lower limbs (HP:0002166)2.31820469
49Septo-optic dysplasia (HP:0100842)2.29012247
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.27560925
51Retinal dysplasia (HP:0007973)2.27301098
52Esotropia (HP:0000565)2.26189930
53Abnormality of the corticospinal tract (HP:0002492)2.26132469
54Absent speech (HP:0001344)2.25955526
55Medulloblastoma (HP:0002885)2.22923192
56Dysmetria (HP:0001310)2.22539875
57Hepatoblastoma (HP:0002884)2.21116431
58Urinary urgency (HP:0000012)2.19371986
59Volvulus (HP:0002580)2.17178912
60Hyperthyroidism (HP:0000836)2.15858919
61Gaze-evoked nystagmus (HP:0000640)2.15639162
62Abnormal lung lobation (HP:0002101)2.15187063
63Amyotrophic lateral sclerosis (HP:0007354)2.15072901
64Hypoventilation (HP:0002791)2.14868065
65Poor suck (HP:0002033)2.13047554
66Abnormality of the hip-girdle musculature (HP:0001445)2.12525099
67Abnormality of the musculature of the pelvis (HP:0001469)2.12525099
68Specific learning disability (HP:0001328)2.12195314
69Truncus arteriosus (HP:0001660)2.11276174
70Spastic gait (HP:0002064)2.10446909
71Intestinal atresia (HP:0011100)2.07805771
72Psychosis (HP:0000709)2.07060531
73Hypoplasia of the brainstem (HP:0002365)2.05195313
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05195313
75Hyperglycinemia (HP:0002154)2.05106516
76Urinary bladder sphincter dysfunction (HP:0002839)2.03756042
77Fetal akinesia sequence (HP:0001989)2.03454370
78Inability to walk (HP:0002540)2.03118339
79Termporal pattern (HP:0011008)2.03101541
80Insidious onset (HP:0003587)2.03101541
81Abnormality of salivation (HP:0100755)2.01945202
82Abnormality of calcium-phosphate metabolism (HP:0100530)2.00349707
83Aplasia/Hypoplasia of the sternum (HP:0006714)2.00014108
84Congenital primary aphakia (HP:0007707)1.99563725
85Generalized myoclonic seizures (HP:0002123)1.99255960
86Protruding tongue (HP:0010808)1.97480204
87Sleep apnea (HP:0010535)1.96798760
88Rimmed vacuoles (HP:0003805)1.95692290
89Medial flaring of the eyebrow (HP:0010747)1.95303723
90Status epilepticus (HP:0002133)1.95266108
91Scanning speech (HP:0002168)1.94405452
92Megalencephaly (HP:0001355)1.93154098
93Acute necrotizing encephalopathy (HP:0006965)1.92496765
94Broad foot (HP:0001769)1.90961377
95Labial hypoplasia (HP:0000066)1.90185624
96True hermaphroditism (HP:0010459)1.89983549
97Abnormality of binocular vision (HP:0011514)1.89812360
98Diplopia (HP:0000651)1.89812360
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88081298
100Abnormality of the labia minora (HP:0012880)1.86570036
101Genetic anticipation (HP:0003743)1.86307094
102Thyroid-stimulating hormone excess (HP:0002925)1.86274512
103Optic nerve hypoplasia (HP:0000609)1.86258826
104Split foot (HP:0001839)1.86023691
105Pachygyria (HP:0001302)1.85479277
106Hypoplastic female external genitalia (HP:0012815)1.85012642
107Impaired smooth pursuit (HP:0007772)1.84872396
108Poor coordination (HP:0002370)1.84168927
109Bradykinesia (HP:0002067)1.83886084
110Stereotypic behavior (HP:0000733)1.82802282
111Morphological abnormality of the pyramidal tract (HP:0002062)1.81920847
112Delusions (HP:0000746)1.81920124
113Anophthalmia (HP:0000528)1.81585445
114Ependymoma (HP:0002888)1.81460974
115Oligodactyly (hands) (HP:0001180)1.81395067
116Genital tract atresia (HP:0001827)1.81239375
117Vaginal atresia (HP:0000148)1.80899250
118Lower limb muscle weakness (HP:0007340)1.80640007
119Postaxial hand polydactyly (HP:0001162)1.80274575
120Akinesia (HP:0002304)1.79106293
121Spastic tetraplegia (HP:0002510)1.78960228
122Agnosia (HP:0010524)1.78698895
123Micropenis (HP:0000054)1.78180972
124Lissencephaly (HP:0001339)1.77976105
125Nephrogenic diabetes insipidus (HP:0009806)1.76975929
126Abnormality of the lower motor neuron (HP:0002366)1.75582525
127Exotropia (HP:0000577)1.74217063
128Progressive macrocephaly (HP:0004481)1.73446387
129Blue irides (HP:0000635)1.73409738
130Degeneration of the lateral corticospinal tracts (HP:0002314)1.72742553
131Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72742553
132Pelvic girdle muscle weakness (HP:0003749)1.72698819
133Restlessness (HP:0000711)1.72633939
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72629131
135Sporadic (HP:0003745)1.71161649
136Narrow forehead (HP:0000341)1.71151013
137Abnormality of the metopic suture (HP:0005556)1.70447794
138Nephronophthisis (HP:0000090)1.70257094
139Short tibia (HP:0005736)1.69699313
140Methylmalonic acidemia (HP:0002912)1.69483704
141Patellar aplasia (HP:0006443)1.68894096
142Pancreatic fibrosis (HP:0100732)1.68005873
143Cutaneous finger syndactyly (HP:0010554)1.66113155
144Abnormality of the astrocytes (HP:0100707)1.65736402
145Astrocytoma (HP:0009592)1.65736402
146Abnormality of midbrain morphology (HP:0002418)1.65024546
147Molar tooth sign on MRI (HP:0002419)1.65024546
148Decreased testicular size (HP:0008734)1.64832978
149High anterior hairline (HP:0009890)1.64649939
150Abnormal mitochondria in muscle tissue (HP:0008316)1.63499930
151Pendular nystagmus (HP:0012043)1.62481924
152Meckel diverticulum (HP:0002245)1.62456128
153Bilateral microphthalmos (HP:0007633)1.61494993
154Cerebral hypomyelination (HP:0006808)1.60343439
155Hemivertebrae (HP:0002937)1.60091755
156Degeneration of anterior horn cells (HP:0002398)1.59079194
157Abnormality of the anterior horn cell (HP:0006802)1.59079194
158Bifid tongue (HP:0010297)1.58512773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.03343781
2MARK14.00966185
3EPHA43.38997958
4MAP3K93.31649601
5MAP3K42.82020737
6MINK12.67753626
7MAP3K122.64656733
8PNCK2.62675309
9WNK32.58757588
10SRPK12.45543819
11NTRK22.45456688
12CASK2.38795111
13MAP4K22.36230174
14MAP2K72.35710330
15KSR12.26439369
16TRIM282.04581281
17UHMK12.02498557
18MAP2K41.80970933
19BUB11.80189891
20NTRK11.76309729
21KSR21.75995360
22PAK61.68794140
23MAPK131.61171022
24NEK11.60360564
25TNIK1.56605819
26CDC71.53181847
27MKNK11.50132680
28SIK21.49685858
29TSSK61.45147851
30TTK1.44668140
31BCR1.44589323
32ARAF1.43675464
33PLK41.43249836
34PLK21.41750899
35CDK51.41588796
36DAPK21.37571729
37MKNK21.37184052
38DYRK31.35599044
39PHKG21.27854774
40PHKG11.27854774
41RIPK41.27578978
42PLK31.27273123
43GRK51.22129157
44WEE11.20233644
45SIK31.18418065
46DYRK21.12652012
47PRKCG1.12521159
48PAK31.11767570
49DAPK11.11283038
50CAMK2A1.10973172
51PLK11.09428165
52WNK41.09208962
53TYRO31.07387419
54LATS21.06935176
55CCNB11.06599598
56CSNK1G21.05709299
57CDK191.03456415
58MAP3K21.02326078
59CAMK2B0.99735858
60ZAK0.99092775
61DYRK1A0.98729201
62PRKD30.96684627
63CDK180.96580430
64CDK140.95683014
65MAPK150.93336971
66BRSK10.93174014
67NME10.93120278
68NEK20.92972926
69PINK10.91898187
70STK160.91476625
71CDK150.88967849
72GRK70.88242561
73FES0.87967575
74PRPF4B0.84779419
75STK38L0.82665703
76BCKDK0.81383146
77RPS6KA40.80180919
78CSNK1G30.79675317
79CDK11A0.78971676
80INSRR0.77502244
81BMPR20.77116942
82ERBB30.76053991
83RAF10.75413286
84VRK10.75054443
85CAMKK10.74488668
86LIMK10.73172634
87FGR0.71190892
88CAMKK20.70872217
89BRSK20.68656467
90OXSR10.68486347
91FER0.64147782
92PRKCE0.63538217
93ADRBK20.61909539
94ATR0.61818663
95CAMK2D0.61756881
96PBK0.61224595
97GRK10.60848110
98RET0.60517493
99MAP3K130.60422526
100STK110.59718332
101AURKA0.58113078
102STK390.57787797
103NUAK10.57154123
104CAMK10.55750451
105SGK10.53567146
106WNK10.52764723
107BMPR1B0.52692108
108CHEK20.51829873
109DYRK1B0.51764015
110EPHB20.51738821
111PRKCZ0.49492465
112PTK2B0.48886509
113ADRBK10.48828673
114CAMK2G0.48737477
115TAF10.48063593
116SGK4940.47816415
117SGK2230.47816415
118STK380.46780256
119AURKB0.45191560
120ATM0.43030379
121CSNK1G10.42825696
122CSNK1A1L0.42757200
123FYN0.41501840
124VRK20.40906793
125CSNK1E0.40599781
126MARK20.39862132
127LMTK20.39615725
128MAP3K10.39579576
129CHEK10.39370852
130ROCK20.38554469
131CSNK1D0.38337433
132CAMK1G0.38232126
133BRAF0.37490424
134RPS6KA30.37475940
135CDC42BPA0.36825940
136PRKCI0.36798012
137CDK30.36380916
138PRKDC0.36159844
139PRKACA0.36128087
140CDK10.36065383
141CSNK1A10.34714604
142* MAPK100.34109146
143MAP2K10.34097439
144PKN10.33851628
145CDK20.33271698
146CSNK2A10.32442854

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.18395041
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19454107
3GABAergic synapse_Homo sapiens_hsa047272.77185399
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69601192
5Amphetamine addiction_Homo sapiens_hsa050312.48062475
6Long-term potentiation_Homo sapiens_hsa047202.47792782
7Circadian entrainment_Homo sapiens_hsa047132.41749231
8Morphine addiction_Homo sapiens_hsa050322.40704315
9Glutamatergic synapse_Homo sapiens_hsa047242.40387590
10Protein export_Homo sapiens_hsa030602.29976590
11Dopaminergic synapse_Homo sapiens_hsa047282.25528682
12Mismatch repair_Homo sapiens_hsa034302.24060614
13Olfactory transduction_Homo sapiens_hsa047402.21174574
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10051605
15Serotonergic synapse_Homo sapiens_hsa047262.08122532
16Non-homologous end-joining_Homo sapiens_hsa034502.06583763
17Fanconi anemia pathway_Homo sapiens_hsa034602.03082127
18Insulin secretion_Homo sapiens_hsa049111.99539507
19Taste transduction_Homo sapiens_hsa047421.96592666
20Steroid biosynthesis_Homo sapiens_hsa001001.94157030
21Cocaine addiction_Homo sapiens_hsa050301.92781586
22Collecting duct acid secretion_Homo sapiens_hsa049661.90973432
23Base excision repair_Homo sapiens_hsa034101.87615792
24Long-term depression_Homo sapiens_hsa047301.86951217
25Oxidative phosphorylation_Homo sapiens_hsa001901.83336947
26Spliceosome_Homo sapiens_hsa030401.82579399
27Salivary secretion_Homo sapiens_hsa049701.81256148
28Cholinergic synapse_Homo sapiens_hsa047251.79823574
29Basal transcription factors_Homo sapiens_hsa030221.71570676
30DNA replication_Homo sapiens_hsa030301.71057686
31Cardiac muscle contraction_Homo sapiens_hsa042601.67974391
32Renin secretion_Homo sapiens_hsa049241.67879475
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62405502
34RNA polymerase_Homo sapiens_hsa030201.61064365
35Gastric acid secretion_Homo sapiens_hsa049711.61007146
36RNA transport_Homo sapiens_hsa030131.54143480
37Parkinsons disease_Homo sapiens_hsa050121.52640602
38Oxytocin signaling pathway_Homo sapiens_hsa049211.51792893
39Cell cycle_Homo sapiens_hsa041101.51741872
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51693672
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50390746
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49876820
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48683920
44Axon guidance_Homo sapiens_hsa043601.45569715
45Vibrio cholerae infection_Homo sapiens_hsa051101.45361609
46Gap junction_Homo sapiens_hsa045401.44561607
47Calcium signaling pathway_Homo sapiens_hsa040201.43318351
48Proteasome_Homo sapiens_hsa030501.42764173
49Alzheimers disease_Homo sapiens_hsa050101.42340228
50RNA degradation_Homo sapiens_hsa030181.36876222
51mRNA surveillance pathway_Homo sapiens_hsa030151.36252115
52GnRH signaling pathway_Homo sapiens_hsa049121.33842844
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32547886
54Propanoate metabolism_Homo sapiens_hsa006401.21514101
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21429180
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17720844
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17145741
58Basal cell carcinoma_Homo sapiens_hsa052171.16254055
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15516374
60Homologous recombination_Homo sapiens_hsa034401.14728864
61Melanogenesis_Homo sapiens_hsa049161.12536260
62Fatty acid elongation_Homo sapiens_hsa000621.11302430
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11139119
64Estrogen signaling pathway_Homo sapiens_hsa049151.09895120
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09410361
66cAMP signaling pathway_Homo sapiens_hsa040241.09385518
67Nucleotide excision repair_Homo sapiens_hsa034201.09308179
68Huntingtons disease_Homo sapiens_hsa050161.08763360
69Regulation of autophagy_Homo sapiens_hsa041401.06845806
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05386981
71Oocyte meiosis_Homo sapiens_hsa041141.03156640
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03076093
73Selenocompound metabolism_Homo sapiens_hsa004501.01155737
74Phototransduction_Homo sapiens_hsa047441.00182796
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.98490638
76ErbB signaling pathway_Homo sapiens_hsa040120.95233999
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91230413
78Pyruvate metabolism_Homo sapiens_hsa006200.89277967
79Pyrimidine metabolism_Homo sapiens_hsa002400.89064325
80Type II diabetes mellitus_Homo sapiens_hsa049300.88207947
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87933662
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.86961594
83Dorso-ventral axis formation_Homo sapiens_hsa043200.86959803
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86880085
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86261304
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85958241
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84870455
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84542446
89Type I diabetes mellitus_Homo sapiens_hsa049400.83890758
90Alcoholism_Homo sapiens_hsa050340.83789430
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81484614
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79142492
93Glioma_Homo sapiens_hsa052140.78108612
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.73966939
95Pancreatic secretion_Homo sapiens_hsa049720.73423406
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71809170
97Purine metabolism_Homo sapiens_hsa002300.70997560
98Thyroid hormone synthesis_Homo sapiens_hsa049180.70667933
99Vitamin B6 metabolism_Homo sapiens_hsa007500.69166692
100Dilated cardiomyopathy_Homo sapiens_hsa054140.69016337
101Choline metabolism in cancer_Homo sapiens_hsa052310.68847797
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68699560
103Wnt signaling pathway_Homo sapiens_hsa043100.66860302
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65517967
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63769916
106MAPK signaling pathway_Homo sapiens_hsa040100.63022306
107Glucagon signaling pathway_Homo sapiens_hsa049220.61230007
108Biosynthesis of amino acids_Homo sapiens_hsa012300.58347282
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56932966
110Ras signaling pathway_Homo sapiens_hsa040140.55130072
111beta-Alanine metabolism_Homo sapiens_hsa004100.54696887
112Prion diseases_Homo sapiens_hsa050200.54430757
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53465180
114Folate biosynthesis_Homo sapiens_hsa007900.52770203
115Arginine and proline metabolism_Homo sapiens_hsa003300.52053096
116Fatty acid metabolism_Homo sapiens_hsa012120.51893683
117Hedgehog signaling pathway_Homo sapiens_hsa043400.51695024
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51680072
119Renal cell carcinoma_Homo sapiens_hsa052110.51606946
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51499417
121VEGF signaling pathway_Homo sapiens_hsa043700.48154382
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47202183
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47135802
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46990438
125TGF-beta signaling pathway_Homo sapiens_hsa043500.46851668
126Sulfur relay system_Homo sapiens_hsa041220.46175215
127Metabolic pathways_Homo sapiens_hsa011000.44527938
128Peroxisome_Homo sapiens_hsa041460.44217351
129Circadian rhythm_Homo sapiens_hsa047100.43843205
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43395288
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.43284702
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43229219
133Rap1 signaling pathway_Homo sapiens_hsa040150.42130162
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38755511
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.38024435
136Butanoate metabolism_Homo sapiens_hsa006500.37327699
137Ovarian steroidogenesis_Homo sapiens_hsa049130.36212660
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35509654
139Carbon metabolism_Homo sapiens_hsa012000.34308375
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33797042
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33113129
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32774465
143Ribosome_Homo sapiens_hsa030100.32650303
144Ether lipid metabolism_Homo sapiens_hsa005650.32311248
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31963963
146Insulin signaling pathway_Homo sapiens_hsa049100.31960503
147Colorectal cancer_Homo sapiens_hsa052100.31428964
148Endocytosis_Homo sapiens_hsa041440.29268443
149Endometrial cancer_Homo sapiens_hsa052130.29150366
150Hippo signaling pathway_Homo sapiens_hsa043900.28880889
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28560484
152Inositol phosphate metabolism_Homo sapiens_hsa005620.26896303
153Phagosome_Homo sapiens_hsa041450.23848315

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