NUDT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.56062549
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.48188689
3maturation of SSU-rRNA (GO:0030490)5.17561807
4viral transcription (GO:0019083)5.02522148
5ribosomal small subunit biogenesis (GO:0042274)4.97499413
6ATP synthesis coupled proton transport (GO:0015986)4.94098907
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.94098907
8translational termination (GO:0006415)4.90808216
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.87753296
10chaperone-mediated protein transport (GO:0072321)4.76559880
11DNA strand elongation involved in DNA replication (GO:0006271)4.65610131
12telomere maintenance via semi-conservative replication (GO:0032201)4.59676144
13DNA deamination (GO:0045006)4.53842418
14pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.45239270
15DNA strand elongation (GO:0022616)4.42976812
16translational elongation (GO:0006414)4.40260363
17ribosomal large subunit biogenesis (GO:0042273)4.39182066
18protein complex biogenesis (GO:0070271)4.32663427
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.28176982
20DNA replication initiation (GO:0006270)4.25292340
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22826801
22cotranslational protein targeting to membrane (GO:0006613)4.21612855
23protein targeting to ER (GO:0045047)4.18077408
24mitochondrial respiratory chain complex assembly (GO:0033108)4.13745228
25respiratory electron transport chain (GO:0022904)4.12497802
26regulation of mitochondrial translation (GO:0070129)4.11340879
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.10557434
28NADH dehydrogenase complex assembly (GO:0010257)4.10557434
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10557434
30nucleobase biosynthetic process (GO:0046112)4.08018662
31telomere maintenance via recombination (GO:0000722)4.07467595
32translational initiation (GO:0006413)4.03078186
33electron transport chain (GO:0022900)4.02937244
34protein localization to endoplasmic reticulum (GO:0070972)3.98093958
35ribonucleoprotein complex biogenesis (GO:0022613)3.96375174
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95778949
37proteasome assembly (GO:0043248)3.94316766
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90435459
39formation of translation preinitiation complex (GO:0001731)3.88230778
40DNA replication checkpoint (GO:0000076)3.82992859
41cellular protein complex disassembly (GO:0043624)3.80860506
42viral life cycle (GO:0019058)3.80828305
43pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.79875937
44purine nucleobase biosynthetic process (GO:0009113)3.76884318
45CENP-A containing nucleosome assembly (GO:0034080)3.76450141
46pyrimidine nucleotide catabolic process (GO:0006244)3.75630227
47mitotic recombination (GO:0006312)3.73062295
48protein neddylation (GO:0045116)3.72884566
49DNA unwinding involved in DNA replication (GO:0006268)3.71074927
50chromatin remodeling at centromere (GO:0031055)3.68160591
51protein targeting to mitochondrion (GO:0006626)3.67689591
52respiratory chain complex IV assembly (GO:0008535)3.61099667
53telomere maintenance via telomere lengthening (GO:0010833)3.60910079
54cytochrome complex assembly (GO:0017004)3.56100125
55folic acid-containing compound biosynthetic process (GO:0009396)3.54584124
56rRNA processing (GO:0006364)3.49882603
57translation (GO:0006412)3.49743851
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.49624672
59ribosome biogenesis (GO:0042254)3.47405950
60establishment of protein localization to mitochondrion (GO:0072655)3.47046194
61base-excision repair, AP site formation (GO:0006285)3.44300888
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43180559
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37992725
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37992725
65transcription-coupled nucleotide-excision repair (GO:0006283)3.37758789
66rRNA metabolic process (GO:0016072)3.37527277
67oxidative phosphorylation (GO:0006119)3.37016762
68protein localization to mitochondrion (GO:0070585)3.35036037
69spliceosomal snRNP assembly (GO:0000387)3.34441622
70protein complex disassembly (GO:0043241)3.33954988
71pseudouridine synthesis (GO:0001522)3.33826753
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32315203
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28224018
74establishment of viral latency (GO:0019043)3.27251505
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.26755212
76termination of RNA polymerase III transcription (GO:0006386)3.26755212
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26106551
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25249443
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24010839
80DNA replication-independent nucleosome organization (GO:0034724)3.23509845
81DNA replication-independent nucleosome assembly (GO:0006336)3.23509845
82cellular component biogenesis (GO:0044085)3.22645336
83positive regulation of ligase activity (GO:0051351)3.21460586
84* deoxyribonucleotide catabolic process (GO:0009264)3.20565386
85mitotic metaphase plate congression (GO:0007080)3.20340168
86rRNA modification (GO:0000154)3.18917963
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17558285
88macromolecular complex disassembly (GO:0032984)3.17468302
89ribosome assembly (GO:0042255)3.17444544
90folic acid metabolic process (GO:0046655)3.16120113
91DNA ligation (GO:0006266)3.14182926
92L-serine metabolic process (GO:0006563)3.13979850
93IMP biosynthetic process (GO:0006188)3.13715006
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13669800
95negative regulation of ligase activity (GO:0051352)3.13669800
96* deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.12636834
97DNA replication-dependent nucleosome organization (GO:0034723)3.11620782
98DNA replication-dependent nucleosome assembly (GO:0006335)3.11620782
99nuclear-transcribed mRNA catabolic process (GO:0000956)3.10349322
100spliceosomal complex assembly (GO:0000245)3.08171875
101pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.06769562
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06162907
103protein localization to kinetochore (GO:0034501)3.05526987
104kinetochore organization (GO:0051383)3.05249582
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01466306
106intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01466306
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99622077
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99622077
109signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99622077
110kinetochore assembly (GO:0051382)2.97937227
111establishment of integrated proviral latency (GO:0075713)2.97281852
112regulation of cellular amino acid metabolic process (GO:0006521)2.96690728
113regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96221111
114L-methionine salvage (GO:0071267)2.95944422
115L-methionine biosynthetic process (GO:0071265)2.95944422
116amino acid salvage (GO:0043102)2.95944422
1177-methylguanosine mRNA capping (GO:0006370)2.95638368
118serine family amino acid biosynthetic process (GO:0009070)2.95504047
119mRNA catabolic process (GO:0006402)2.94943564
120pteridine-containing compound biosynthetic process (GO:0042559)2.94844828
121signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94809287
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.94809287
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93954320
124IMP metabolic process (GO:0046040)2.93652797
125G1/S transition of mitotic cell cycle (GO:0000082)2.91886480
126cell cycle G1/S phase transition (GO:0044843)2.91886480
1277-methylguanosine RNA capping (GO:0009452)2.90658254
128RNA capping (GO:0036260)2.90658254
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.89444469
130glycine metabolic process (GO:0006544)2.88777318
131pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.88069090
132histone exchange (GO:0043486)2.87898547
133RNA catabolic process (GO:0006401)2.86730238
134nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85711366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.24235562
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.25969160
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84165198
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74189881
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.25757381
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.22747463
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13654564
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13222949
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98464659
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.97696106
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90128346
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89081196
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.80016672
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78920335
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78199316
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77876092
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77822791
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57202230
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57095791
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51272291
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49345102
22XRN2_22483619_ChIP-Seq_HELA_Human2.36468895
23VDR_23849224_ChIP-Seq_CD4+_Human2.29627943
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19178649
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17664137
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13517143
27FOXP3_21729870_ChIP-Seq_TREG_Human2.03118111
28DCP1A_22483619_ChIP-Seq_HELA_Human2.03042539
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89633793
30AR_21909140_ChIP-Seq_LNCAP_Human1.85995877
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85563259
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.84030020
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81650503
34GABP_19822575_ChIP-Seq_HepG2_Human1.80612835
35TTF2_22483619_ChIP-Seq_HELA_Human1.80464518
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77095639
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68615922
38ELK1_19687146_ChIP-ChIP_HELA_Human1.68400538
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66124664
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64396711
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64065392
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.63681268
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62881950
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62842617
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58366860
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.58294271
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58168508
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54870441
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53765189
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52617814
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51505174
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48181003
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46639614
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43922113
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42732655
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39476135
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38524789
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33122980
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30514986
60KDM5A_27292631_Chip-Seq_BREAST_Human1.29658990
61CIITA_25753668_ChIP-Seq_RAJI_Human1.27002321
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23029360
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19702644
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19231895
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19141893
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12503484
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11536481
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11340644
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11276329
70MYC_18940864_ChIP-ChIP_HL60_Human1.09193812
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07060539
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06985431
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06357385
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05351822
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04277686
76ELK1_22589737_ChIP-Seq_MCF10A_Human0.99882307
77KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99838354
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98779744
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98277467
80CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97395272
81SPI1_23547873_ChIP-Seq_NB4_Human0.95153168
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94989532
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94776991
84FOXP1_21924763_ChIP-Seq_HESCs_Human0.94668566
85TFEB_21752829_ChIP-Seq_HELA_Human0.93942812
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93911882
87* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93823044
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92419705
89* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90689142
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90075402
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89573835
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.88531258
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88252084
94ZNF274_21170338_ChIP-Seq_K562_Hela0.86700539
95* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85708931
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.85618596
97MYC_22102868_ChIP-Seq_BL_Human0.84979074
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84444888
99* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83942448
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83810812
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82826962
102* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82652658
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82235735
104VDR_21846776_ChIP-Seq_THP-1_Human0.80720179
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77539354
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.77466596
107PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77132014
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.75731053
109* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75647359
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.75014066
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72877206
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72646444
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.71054311
114CTCF_26484167_Chip-Seq_Bcells_Mouse0.70893287
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70761085
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69578866
117BCL6_27268052_Chip-Seq_Bcells_Human0.69056192
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.68237265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05961369
2MP0003806_abnormal_nucleotide_metabolis4.63212948
3MP0004957_abnormal_blastocyst_morpholog4.06190937
4MP0010094_abnormal_chromosome_stability3.90113118
5MP0003111_abnormal_nucleus_morphology3.80230695
6MP0008057_abnormal_DNA_replication3.55016518
7MP0003077_abnormal_cell_cycle3.47204843
8MP0000372_irregular_coat_pigmentation3.01443762
9MP0008058_abnormal_DNA_repair2.87797948
10MP0003186_abnormal_redox_activity2.65358480
11MP0002396_abnormal_hematopoietic_system2.52003547
12MP0008932_abnormal_embryonic_tissue2.47866866
13MP0003136_yellow_coat_color2.46629811
14MP0002139_abnormal_hepatobiliary_system2.44322436
15MP0008007_abnormal_cellular_replicative2.29403980
16MP0009379_abnormal_foot_pigmentation2.27006801
17MP0003718_maternal_effect1.99374007
18MP0005360_urolithiasis1.88818667
19MP0002132_abnormal_respiratory_system1.83171227
20MP0003786_premature_aging1.79171688
21MP0005085_abnormal_gallbladder_physiolo1.77835142
22MP0000490_abnormal_crypts_of1.76441540
23MP0001730_embryonic_growth_arrest1.75679708
24MP0006036_abnormal_mitochondrial_physio1.73677040
25MP0000350_abnormal_cell_proliferation1.66299927
26MP0009840_abnormal_foam_cell1.56858240
27MP0005365_abnormal_bile_salt1.50458143
28MP0009333_abnormal_splenocyte_physiolog1.49261726
29MP0005075_abnormal_melanosome_morpholog1.46547837
30MP0002736_abnormal_nociception_after1.45454214
31MP0001764_abnormal_homeostasis1.44132665
32MP0005084_abnormal_gallbladder_morpholo1.43608835
33MP0008789_abnormal_olfactory_epithelium1.40837091
34MP0003656_abnormal_erythrocyte_physiolo1.40618921
35MP0006072_abnormal_retinal_apoptosis1.38627548
36MP0010030_abnormal_orbit_morphology1.34167280
37MP0009697_abnormal_copulation1.34049147
38MP0003646_muscle_fatigue1.32459778
39* MP0002019_abnormal_tumor_incidence1.30271749
40MP0002163_abnormal_gland_morphology1.26968676
41MP0008875_abnormal_xenobiotic_pharmacok1.21784403
42MP0000313_abnormal_cell_death1.19126210
43MP0006035_abnormal_mitochondrial_morpho1.18147252
44MP0001853_heart_inflammation1.17572996
45MP0002080_prenatal_lethality1.16842209
46MP0008995_early_reproductive_senescence1.16418880
47MP0004147_increased_porphyrin_level1.14573561
48MP0002653_abnormal_ependyma_morphology1.14040304
49MP0005397_hematopoietic_system_phenotyp1.13332557
50MP0001545_abnormal_hematopoietic_system1.13332557
51MP0001697_abnormal_embryo_size1.10521444
52MP0003567_abnormal_fetal_cardiomyocyte1.10240185
53MP0002277_abnormal_respiratory_mucosa1.09966161
54MP0001293_anophthalmia1.09236868
55MP0002148_abnormal_hypersensitivity_rea1.08911898
56MP0005380_embryogenesis_phenotype1.08531172
57MP0001672_abnormal_embryogenesis/_devel1.08531172
58MP0005408_hypopigmentation1.08281541
59MP0003763_abnormal_thymus_physiology1.08223162
60MP0010352_gastrointestinal_tract_polyps1.06911492
61MP0002837_dystrophic_cardiac_calcinosis1.06615546
62MP0009278_abnormal_bone_marrow1.01812120
63MP0000015_abnormal_ear_pigmentation1.01797769
64MP0005266_abnormal_metabolism1.01738197
65MP0005332_abnormal_amino_acid0.99604368
66MP0000689_abnormal_spleen_morphology0.99436467
67MP0002722_abnormal_immune_system0.98639556
68MP0005083_abnormal_biliary_tract0.97550772
69MP0002398_abnormal_bone_marrow0.97518128
70MP0005174_abnormal_tail_pigmentation0.96939039
71MP0001968_abnormal_touch/_nociception0.94844065
72MP0005499_abnormal_olfactory_system0.94632175
73MP0005394_taste/olfaction_phenotype0.94632175
74MP0003123_paternal_imprinting0.92426831
75MP0003984_embryonic_growth_retardation0.91629692
76MP0006292_abnormal_olfactory_placode0.90990578
77MP0002429_abnormal_blood_cell0.90837657
78MP0000049_abnormal_middle_ear0.89923842
79MP0000358_abnormal_cell_content/0.89585195
80MP0002088_abnormal_embryonic_growth/wei0.88938243
81MP0001835_abnormal_antigen_presentation0.88621441
82MP0010307_abnormal_tumor_latency0.87211238
83MP0005171_absent_coat_pigmentation0.86760003
84MP0003315_abnormal_perineum_morphology0.86077365
85MP0002160_abnormal_reproductive_system0.84943658
86MP0002085_abnormal_embryonic_tissue0.84547295
87MP0003698_abnormal_male_reproductive0.84238555
88MP0002210_abnormal_sex_determination0.83967499
89MP0005410_abnormal_fertilization0.83706035
90MP0005451_abnormal_body_composition0.83186383
91MP0000703_abnormal_thymus_morphology0.83112173
92MP0008872_abnormal_physiological_respon0.82943631
93MP0001919_abnormal_reproductive_system0.81795462
94MP0002234_abnormal_pharynx_morphology0.79617887
95MP0002086_abnormal_extraembryonic_tissu0.79192014
96MP0005319_abnormal_enzyme/_coenzyme0.77916069
97MP0001986_abnormal_taste_sensitivity0.77736619
98MP0000598_abnormal_liver_morphology0.77342390
99MP0004197_abnormal_fetal_growth/weight/0.76719973
100MP0002254_reproductive_system_inflammat0.76694860
101MP0003121_genomic_imprinting0.75631460
102MP0001905_abnormal_dopamine_level0.75602717
103MP0005376_homeostasis/metabolism_phenot0.75578354
104MP0000716_abnormal_immune_system0.75104098
105MP0002102_abnormal_ear_morphology0.75017336
106MP0001145_abnormal_male_reproductive0.74384884
107MP0004808_abnormal_hematopoietic_stem0.73947161
108MP0004381_abnormal_hair_follicle0.73540178
109MP0005025_abnormal_response_to0.72302875
110MP0001119_abnormal_female_reproductive0.72094376
111MP0005551_abnormal_eye_electrophysiolog0.71719453
112MP0008877_abnormal_DNA_methylation0.71638002
113MP0009785_altered_susceptibility_to0.70849120
114MP0009053_abnormal_anal_canal0.70625985
115MP0000858_altered_metastatic_potential0.70502032
116MP0005671_abnormal_response_to0.70389497
117MP0005501_abnormal_skin_physiology0.70234136
118MP0003011_delayed_dark_adaptation0.69629739
119MP0002095_abnormal_skin_pigmentation0.69290560
120MP0005464_abnormal_platelet_physiology0.69159297
121MP0000609_abnormal_liver_physiology0.68582955
122MP0001800_abnormal_humoral_immune0.68491337
123MP0002938_white_spotting0.66937120
124MP0001529_abnormal_vocalization0.65926106
125MP0000653_abnormal_sex_gland0.65908030
126MP0004133_heterotaxia0.65854083
127MP0008469_abnormal_protein_level0.64339252
128MP0005253_abnormal_eye_physiology0.64094094
129MP0001324_abnormal_eye_pigmentation0.62577884
130MP0001929_abnormal_gametogenesis0.62041984
131MP0002405_respiratory_system_inflammati0.61784528
132MP0005389_reproductive_system_phenotype0.61504207
133MP0001666_abnormal_nutrient_absorption0.61274106
134MP0002420_abnormal_adaptive_immunity0.60685998
135MP0005645_abnormal_hypothalamus_physiol0.60465312
136MP0003191_abnormal_cellular_cholesterol0.59955723
137MP0001819_abnormal_immune_cell0.59859289
138MP0004142_abnormal_muscle_tone0.59673620

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.40175532
2Abnormality of cells of the erythroid lineage (HP:0012130)5.34229574
3Abnormal number of erythroid precursors (HP:0012131)5.13935511
4Birth length less than 3rd percentile (HP:0003561)4.36285478
5Macrocytic anemia (HP:0001972)4.00418847
6Oral leukoplakia (HP:0002745)3.85361840
7Aplastic anemia (HP:0001915)3.69444715
8Pallor (HP:0000980)3.46709798
9Abnormality of pyrimidine metabolism (HP:0004353)3.24889650
10Breast hypoplasia (HP:0003187)3.20237922
11Cerebral hypomyelination (HP:0006808)3.10098938
12Respiratory difficulties (HP:0002880)3.03927638
13Acute necrotizing encephalopathy (HP:0006965)3.01834138
14Hepatocellular necrosis (HP:0001404)2.97823627
15Rough bone trabeculation (HP:0100670)2.97532249
16Hepatic necrosis (HP:0002605)2.95600285
17Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94035437
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94035437
19Mitochondrial inheritance (HP:0001427)2.85490123
20Abnormality of glycolysis (HP:0004366)2.85051843
21Increased serum pyruvate (HP:0003542)2.85051843
22Abnormal mitochondria in muscle tissue (HP:0008316)2.82534524
23Acute encephalopathy (HP:0006846)2.81302486
24Increased serum lactate (HP:0002151)2.79770087
25Chromsome breakage (HP:0040012)2.78296127
26Hypobetalipoproteinemia (HP:0003563)2.75688785
27Increased CSF lactate (HP:0002490)2.75237974
28Multiple enchondromatosis (HP:0005701)2.72672117
29Abnormality of the heme biosynthetic pathway (HP:0010472)2.71230800
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68771432
31Carpal bone hypoplasia (HP:0001498)2.68625786
323-Methylglutaconic aciduria (HP:0003535)2.68430782
33Optic disc pallor (HP:0000543)2.67387942
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63555760
35Abnormal protein N-linked glycosylation (HP:0012347)2.63555760
36Abnormal protein glycosylation (HP:0012346)2.63555760
37Abnormal glycosylation (HP:0012345)2.63555760
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62901768
39Thrombocytosis (HP:0001894)2.61001242
40Cerebral edema (HP:0002181)2.58960020
41Colon cancer (HP:0003003)2.57754522
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53022203
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.48852299
44Pancytopenia (HP:0001876)2.48704396
45Increased hepatocellular lipid droplets (HP:0006565)2.46578758
46Lipid accumulation in hepatocytes (HP:0006561)2.45064328
47Leukodystrophy (HP:0002415)2.42397513
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41526007
49Abnormality of reticulocytes (HP:0004312)2.37815659
50Abnormality of the anterior horn cell (HP:0006802)2.34794620
51Degeneration of anterior horn cells (HP:0002398)2.34794620
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26424792
53Type I transferrin isoform profile (HP:0003642)2.26150980
5411 pairs of ribs (HP:0000878)2.25312389
55Megaloblastic anemia (HP:0001889)2.23913083
56Progressive macrocephaly (HP:0004481)2.23272937
57Abnormality of renal resorption (HP:0011038)2.22917306
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22750914
59Premature graying of hair (HP:0002216)2.21057028
60Abnormality of the preputium (HP:0100587)2.20961636
61Patellar aplasia (HP:0006443)2.20468765
62Microretrognathia (HP:0000308)2.19579928
63Duplicated collecting system (HP:0000081)2.18529666
64Absent thumb (HP:0009777)2.18200176
65Cellular immunodeficiency (HP:0005374)2.17599283
66CNS demyelination (HP:0007305)2.17535106
67Cleft eyelid (HP:0000625)2.16615055
68Poor head control (HP:0002421)2.16262480
69Methylmalonic aciduria (HP:0012120)2.15090780
70Horseshoe kidney (HP:0000085)2.14506571
71Abnormal trabecular bone morphology (HP:0100671)2.13951040
72Bone marrow hypocellularity (HP:0005528)2.11744775
73Exertional dyspnea (HP:0002875)2.10676298
74Meckel diverticulum (HP:0002245)2.09861990
75Abnormality of chromosome stability (HP:0003220)2.09361430
76Aplasia/Hypoplasia of the patella (HP:0006498)2.08966525
77Hyperglycinemia (HP:0002154)2.07079302
78Lactic acidosis (HP:0003128)2.07030182
79Reduced antithrombin III activity (HP:0001976)2.04815523
80Selective tooth agenesis (HP:0001592)2.03063940
81Progressive muscle weakness (HP:0003323)2.02106238
82Renal Fanconi syndrome (HP:0001994)2.02106169
83Abnormal hemoglobin (HP:0011902)2.01599432
84Abnormality of the ileum (HP:0001549)2.01404135
85Progressive microcephaly (HP:0000253)2.01144991
86Premature ovarian failure (HP:0008209)2.00849958
87Pancreatic cysts (HP:0001737)2.00161633
88Intrahepatic cholestasis (HP:0001406)1.99068087
89Pancreatic fibrosis (HP:0100732)1.98400093
90Respiratory failure (HP:0002878)1.97298904
91Microvesicular hepatic steatosis (HP:0001414)1.96431512
92Abnormality of methionine metabolism (HP:0010901)1.96238322
93Lethargy (HP:0001254)1.96065181
94Pendular nystagmus (HP:0012043)1.95652352
95Dicarboxylic aciduria (HP:0003215)1.95033369
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95033369
97Myelodysplasia (HP:0002863)1.94376477
98Increased intramyocellular lipid droplets (HP:0012240)1.94338427
99Emotional lability (HP:0000712)1.93367873
100Nausea (HP:0002018)1.93279850
101Sparse eyelashes (HP:0000653)1.93200900
102Secondary amenorrhea (HP:0000869)1.92449444
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91685045
104Stenosis of the external auditory canal (HP:0000402)1.90550057
105Absent radius (HP:0003974)1.90411977
106Exercise intolerance (HP:0003546)1.89239783
107Abnormality of the renal collecting system (HP:0004742)1.89146921
108Triphalangeal thumb (HP:0001199)1.86200808
109CNS hypomyelination (HP:0003429)1.86114344
110Duodenal stenosis (HP:0100867)1.85358263
111Small intestinal stenosis (HP:0012848)1.85358263
112Abnormality of serum amino acid levels (HP:0003112)1.84693732
113Abnormality of serine family amino acid metabolism (HP:0010894)1.84622783
114Abnormality of glycine metabolism (HP:0010895)1.84622783
115IgM deficiency (HP:0002850)1.83575837
116Impulsivity (HP:0100710)1.83233787
117B lymphocytopenia (HP:0010976)1.81712425
118Trismus (HP:0000211)1.79562953
119Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79542596
120Increased muscle lipid content (HP:0009058)1.76637531
121Abnormality of the labia minora (HP:0012880)1.76613781
122Petechiae (HP:0000967)1.76496503
123Severe visual impairment (HP:0001141)1.73848326
124Abnormality of urine glucose concentration (HP:0011016)1.71880286
125Glycosuria (HP:0003076)1.71880286
126Congenital stationary night blindness (HP:0007642)1.71823870
127True hermaphroditism (HP:0010459)1.70538639
128Neutropenia (HP:0001875)1.70297109
129Sclerocornea (HP:0000647)1.67011561
130Opisthotonus (HP:0002179)1.65659778
131Gliosis (HP:0002171)1.65133218
132Abnormality of B cell number (HP:0010975)1.64488532
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64063924
134Hyperalaninemia (HP:0003348)1.64063924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.46379908
2BUB14.46790531
3WEE14.24996437
4EIF2AK13.60447753
5STK163.59488108
6NME23.26821927
7CDC72.80629694
8SRPK12.37733164
9TLK12.37229931
10NUAK12.35482794
11TAF12.18120633
12VRK12.17123691
13BCKDK2.05337295
14EIF2AK32.03326452
15PBK1.92485702
16PIM21.83710100
17TESK21.83685141
18TTK1.83111460
19PLK41.81153866
20ACVR1B1.78453212
21TSSK61.76224242
22NEK21.75086784
23DYRK31.73274495
24BRSK21.72068687
25CDK71.65801771
26PLK11.65308795
27NEK11.64729564
28RPS6KB21.61607682
29AURKB1.49559848
30PASK1.41156059
31MKNK11.40022139
32EPHA21.34715454
33KDR1.33368466
34ATR1.30187252
35SCYL21.28338092
36MAP3K81.17292357
37IRAK31.15994582
38MST41.15012590
39AURKA1.14520634
40MAP4K11.14010797
41RPS6KA41.11671404
42STK41.11288079
43STK101.11153766
44LRRK21.08714239
45DAPK11.08706557
46BRSK11.07267599
47IRAK41.03854520
48ABL21.02050698
49MAP3K111.02016503
50PDK21.01355041
51ZAK0.98642693
52MAP4K20.98128221
53PAK40.92687731
54CHEK20.92119160
55PIM10.91555126
56PLK30.91499567
57EIF2AK20.89120733
58FLT30.88759282
59CDK40.87355512
60BMPR1B0.85608370
61BTK0.84170341
62WNK30.83548539
63TESK10.81760113
64TGFBR10.80932172
65CSNK2A20.80920642
66CDK80.80277863
67CSNK2A10.80260347
68CHEK10.79908316
69KIT0.79790259
70SMG10.78551253
71TYK20.74861068
72TRIM280.74506668
73TEC0.69419204
74NME10.69371749
75MAP2K30.67622907
76BRAF0.66750449
77RPS6KA50.66581743
78PAK10.65639337
79CCNB10.64175402
80LIMK10.63456464
81MKNK20.60197700
82ADRBK20.59304180
83DYRK20.58789780
84ILK0.58554007
85CSNK1G20.58529378
86GRK10.58004391
87DAPK30.56939919
88BLK0.56900915
89CLK10.56236954
90CSNK1A1L0.54740168
91CSNK1G30.53253375
92ATM0.52878101
93CDK20.51108700
94IKBKB0.49386401
95MARK30.47082909
96CSF1R0.46426026
97MAPKAPK30.43901090
98MAP3K120.43104092
99GRK60.42478602
100MUSK0.40579024
101CDK190.39845850
102INSRR0.39761976
103MAP3K30.39391696
104CDK10.37145333
105PRKCI0.36504102
106TAOK20.35751912
107ZAP700.35498531
108LYN0.33732041
109MAPKAPK50.33142904
110GRK50.33130614
111TXK0.31867528
112MAPK110.30107511
113ARAF0.29121269
114MAP2K70.28700406
115RPS6KA60.27968990
116RPS6KC10.26732930
117RPS6KL10.26732930
118CSNK1G10.26171956
119CDK60.25399222
120JAK30.25272443
121MAP2K60.25043603
122SYK0.24544035
123PNCK0.24060635
124PIK3CG0.20427218

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29138100
2Ribosome_Homo sapiens_hsa030104.17507918
3Mismatch repair_Homo sapiens_hsa034303.49423177
4Proteasome_Homo sapiens_hsa030503.47866386
5RNA polymerase_Homo sapiens_hsa030203.21244020
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69337525
7Homologous recombination_Homo sapiens_hsa034402.60011370
8Spliceosome_Homo sapiens_hsa030402.56100779
9One carbon pool by folate_Homo sapiens_hsa006702.50576712
10Pyrimidine metabolism_Homo sapiens_hsa002402.49517734
11Base excision repair_Homo sapiens_hsa034102.42519161
12Nucleotide excision repair_Homo sapiens_hsa034202.41120449
13RNA transport_Homo sapiens_hsa030132.05418943
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68498821
15Folate biosynthesis_Homo sapiens_hsa007901.66667775
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63283360
17Cell cycle_Homo sapiens_hsa041101.63122980
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58426989
19Fanconi anemia pathway_Homo sapiens_hsa034601.57376943
20Non-homologous end-joining_Homo sapiens_hsa034501.51915313
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.46804632
22Basal transcription factors_Homo sapiens_hsa030221.42656569
23RNA degradation_Homo sapiens_hsa030181.42444103
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.35446686
25Protein export_Homo sapiens_hsa030601.32701888
26Parkinsons disease_Homo sapiens_hsa050121.31737313
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30445689
28Oxidative phosphorylation_Homo sapiens_hsa001901.28186998
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27619784
30Purine metabolism_Homo sapiens_hsa002301.22254250
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21727082
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.20548157
33Glutathione metabolism_Homo sapiens_hsa004801.20263948
34Cardiac muscle contraction_Homo sapiens_hsa042601.18953066
35Pentose phosphate pathway_Homo sapiens_hsa000301.16923719
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16823293
37Sulfur relay system_Homo sapiens_hsa041221.08872966
38Biosynthesis of amino acids_Homo sapiens_hsa012301.08555038
39Huntingtons disease_Homo sapiens_hsa050161.05820823
40Selenocompound metabolism_Homo sapiens_hsa004501.05202452
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02609855
42Vitamin B6 metabolism_Homo sapiens_hsa007500.99615390
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.96356633
44Asthma_Homo sapiens_hsa053100.94975462
45Fatty acid elongation_Homo sapiens_hsa000620.92360208
46Carbon metabolism_Homo sapiens_hsa012000.90280005
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89607955
48p53 signaling pathway_Homo sapiens_hsa041150.88152859
49Systemic lupus erythematosus_Homo sapiens_hsa053220.86692918
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84549234
51Peroxisome_Homo sapiens_hsa041460.83751876
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83024383
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80875800
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80822581
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78746994
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77091064
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77056002
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75314472
59Chemical carcinogenesis_Homo sapiens_hsa052040.74807217
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74288690
61Phototransduction_Homo sapiens_hsa047440.73760632
62Epstein-Barr virus infection_Homo sapiens_hsa051690.71577228
63Histidine metabolism_Homo sapiens_hsa003400.69230551
64mRNA surveillance pathway_Homo sapiens_hsa030150.68594079
65Arginine and proline metabolism_Homo sapiens_hsa003300.68158115
66Caffeine metabolism_Homo sapiens_hsa002320.68116748
67beta-Alanine metabolism_Homo sapiens_hsa004100.67656614
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67595932
69Metabolic pathways_Homo sapiens_hsa011000.66340855
70Steroid biosynthesis_Homo sapiens_hsa001000.65676120
71Retinol metabolism_Homo sapiens_hsa008300.63974340
72Propanoate metabolism_Homo sapiens_hsa006400.62695096
73Tryptophan metabolism_Homo sapiens_hsa003800.61437580
74Fatty acid degradation_Homo sapiens_hsa000710.60917571
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.56960186
76Pyruvate metabolism_Homo sapiens_hsa006200.56770559
77Alzheimers disease_Homo sapiens_hsa050100.56153888
78Phenylalanine metabolism_Homo sapiens_hsa003600.54650547
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51806618
80Tyrosine metabolism_Homo sapiens_hsa003500.49622084
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.46459641
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45994705
83Allograft rejection_Homo sapiens_hsa053300.45868000
84N-Glycan biosynthesis_Homo sapiens_hsa005100.45106798
85Herpes simplex infection_Homo sapiens_hsa051680.45076542
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44321414
87Arachidonic acid metabolism_Homo sapiens_hsa005900.42691236
88Fructose and mannose metabolism_Homo sapiens_hsa000510.42169824
89Autoimmune thyroid disease_Homo sapiens_hsa053200.42139762
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41696199
91Antigen processing and presentation_Homo sapiens_hsa046120.39571675
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39258893
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38936977
94Fatty acid metabolism_Homo sapiens_hsa012120.38550103
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36207765
96Viral carcinogenesis_Homo sapiens_hsa052030.34585591
97Linoleic acid metabolism_Homo sapiens_hsa005910.34008741
98Graft-versus-host disease_Homo sapiens_hsa053320.33057559
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32856495
100Primary immunodeficiency_Homo sapiens_hsa053400.32840237
101Arginine biosynthesis_Homo sapiens_hsa002200.32779291
102Galactose metabolism_Homo sapiens_hsa000520.32247758
103Oocyte meiosis_Homo sapiens_hsa041140.30450160
104Vitamin digestion and absorption_Homo sapiens_hsa049770.30084571
105Legionellosis_Homo sapiens_hsa051340.28754640
106Complement and coagulation cascades_Homo sapiens_hsa046100.27761926
107Sulfur metabolism_Homo sapiens_hsa009200.27714710
108Butanoate metabolism_Homo sapiens_hsa006500.26694852
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26538299
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22841817
111Collecting duct acid secretion_Homo sapiens_hsa049660.22105519
112Thyroid cancer_Homo sapiens_hsa052160.21263302
113Hematopoietic cell lineage_Homo sapiens_hsa046400.19809164
114Type I diabetes mellitus_Homo sapiens_hsa049400.19666359
115Alcoholism_Homo sapiens_hsa050340.19448248
116Regulation of autophagy_Homo sapiens_hsa041400.19398898
117Rheumatoid arthritis_Homo sapiens_hsa053230.18796995
118Fat digestion and absorption_Homo sapiens_hsa049750.17072021
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16845595
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16320198
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15930822
122HTLV-I infection_Homo sapiens_hsa051660.12947416

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