NUDCD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.32148536
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.23019180
3synaptic vesicle maturation (GO:0016188)5.15822991
4synaptic vesicle exocytosis (GO:0016079)5.10041424
5locomotory exploration behavior (GO:0035641)4.99120766
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83786513
7positive regulation of synapse maturation (GO:0090129)4.81471154
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76565181
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.67676900
10vocalization behavior (GO:0071625)4.63532452
11layer formation in cerebral cortex (GO:0021819)4.61527513
12regulation of glutamate receptor signaling pathway (GO:1900449)4.47189825
13protein localization to synapse (GO:0035418)4.39064229
14glutamate secretion (GO:0014047)4.35426906
15regulation of synaptic vesicle exocytosis (GO:2000300)4.23392052
16proline transport (GO:0015824)4.05941850
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.02536109
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00439270
19cerebellar granule cell differentiation (GO:0021707)3.98921270
20regulation of synapse structural plasticity (GO:0051823)3.96429176
21regulation of synaptic vesicle transport (GO:1902803)3.93192312
22regulation of neuronal synaptic plasticity (GO:0048168)3.90304559
23amino acid import (GO:0043090)3.85557403
24dendritic spine morphogenesis (GO:0060997)3.83672988
25gamma-aminobutyric acid transport (GO:0015812)3.82243072
26exploration behavior (GO:0035640)3.81556666
27neuron cell-cell adhesion (GO:0007158)3.79768438
28synaptic transmission, glutamatergic (GO:0035249)3.79749302
29regulation of synapse maturation (GO:0090128)3.76488477
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75710795
31neurotransmitter secretion (GO:0007269)3.72049227
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.71800605
33synaptic vesicle endocytosis (GO:0048488)3.66240141
34neuronal action potential propagation (GO:0019227)3.65328074
35neuron recognition (GO:0008038)3.57202527
36G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.55484595
37L-amino acid import (GO:0043092)3.55302304
38glutamate receptor signaling pathway (GO:0007215)3.53700249
39regulation of ARF protein signal transduction (GO:0032012)3.50508880
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48532124
41neuron-neuron synaptic transmission (GO:0007270)3.47112205
42regulation of dendritic spine morphogenesis (GO:0061001)3.44769671
43negative regulation of dendrite morphogenesis (GO:0050774)3.41446217
44cell communication by electrical coupling (GO:0010644)3.38405351
45axonal fasciculation (GO:0007413)3.38116102
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34225041
47regulation of voltage-gated calcium channel activity (GO:1901385)3.33779717
48establishment of mitochondrion localization (GO:0051654)3.31845535
49cerebellar Purkinje cell differentiation (GO:0021702)3.27171843
50activation of protein kinase A activity (GO:0034199)3.26083595
51positive regulation of membrane potential (GO:0045838)3.25663123
52long-term memory (GO:0007616)3.24117936
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20181336
54potassium ion homeostasis (GO:0055075)3.19375280
55cerebellar Purkinje cell layer development (GO:0021680)3.19082142
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16557812
57cell communication involved in cardiac conduction (GO:0086065)3.15265471
58neuromuscular process controlling balance (GO:0050885)3.14820212
59cellular potassium ion homeostasis (GO:0030007)3.12658999
60cell migration in hindbrain (GO:0021535)3.11884870
61regulation of synaptic plasticity (GO:0048167)3.09540759
62regulation of postsynaptic membrane potential (GO:0060078)3.08423809
63central nervous system projection neuron axonogenesis (GO:0021952)3.07535786
64negative regulation of microtubule polymerization (GO:0031115)3.05954342
65neurotransmitter-gated ion channel clustering (GO:0072578)3.05387781
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03573770
67regulation of vesicle fusion (GO:0031338)3.02839781
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00875826
69dendritic spine organization (GO:0097061)2.99097718
70cellular sodium ion homeostasis (GO:0006883)2.97134604
71positive regulation of dendritic spine morphogenesis (GO:0061003)2.96943859
72vesicle docking involved in exocytosis (GO:0006904)2.96056449
73dendrite morphogenesis (GO:0048813)2.96006938
74neurotransmitter transport (GO:0006836)2.95003957
75gamma-aminobutyric acid signaling pathway (GO:0007214)2.94518913
76detection of calcium ion (GO:0005513)2.93501779
77sodium ion export (GO:0071436)2.91357471
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90937686
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90084432
80behavioral defense response (GO:0002209)2.89923695
81behavioral fear response (GO:0001662)2.89923695
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89490247
83regulation of neurotransmitter transport (GO:0051588)2.88285295
84regulation of membrane repolarization (GO:0060306)2.85748939
85transmission of nerve impulse (GO:0019226)2.85072213
86innervation (GO:0060384)2.82496098
87membrane depolarization during action potential (GO:0086010)2.82419667
88membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81348290
89positive regulation of neurotransmitter transport (GO:0051590)2.79815325
90auditory behavior (GO:0031223)2.79575448
91negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79458292
92regulation of synaptic transmission, glutamatergic (GO:0051966)2.78880051
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78467359
94positive regulation of neurotransmitter secretion (GO:0001956)2.78369767
95potassium ion import (GO:0010107)2.77484342
96membrane repolarization (GO:0086009)2.77330709
97regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.77060537
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76118971
99fear response (GO:0042596)2.73818138
100regulation of neurotransmitter secretion (GO:0046928)2.73429136
101positive regulation of dendritic spine development (GO:0060999)2.72597683
102membrane depolarization (GO:0051899)2.71627774
103regulation of dendritic spine development (GO:0060998)2.71420870
104regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.71361432
105cerebellum development (GO:0021549)2.70952364
106prepulse inhibition (GO:0060134)2.70555168
107establishment of synaptic vesicle localization (GO:0097480)2.70228947
108synaptic vesicle transport (GO:0048489)2.70228947
109neuromuscular synaptic transmission (GO:0007274)2.70101972
110neuronal ion channel clustering (GO:0045161)2.69224387
111peptidyl-arginine omega-N-methylation (GO:0035247)2.68175198
112regulation of neurotransmitter levels (GO:0001505)2.67666727
113postsynaptic membrane organization (GO:0001941)2.67377922
114synapse organization (GO:0050808)2.66946334
115vesicle docking (GO:0048278)2.66925611
116regulation of cell communication by electrical coupling (GO:0010649)2.66393502
117mitochondrion transport along microtubule (GO:0047497)2.64689829
118establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64689829
119learning (GO:0007612)2.64656095
120synaptic transmission (GO:0007268)2.64327019
121protein targeting to plasma membrane (GO:0072661)2.64214169
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.64161054
123plasma membrane repair (GO:0001778)2.63892801
124vesicle transport along microtubule (GO:0047496)2.63855225
125regulation of synaptic transmission (GO:0050804)2.60236814
126regulation of dendrite morphogenesis (GO:0048814)2.59857251
127positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.58052483
128dopamine receptor signaling pathway (GO:0007212)2.54339668
129positive regulation of dendrite development (GO:1900006)2.53981403
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52801321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.78437287
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.50584117
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.07303765
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04747535
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94053107
6REST_21632747_ChIP-Seq_MESCs_Mouse2.83784765
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78753379
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75474720
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74232132
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74232132
11GBX2_23144817_ChIP-Seq_PC3_Human2.71537731
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.63079422
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61559839
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.52307887
15DROSHA_22980978_ChIP-Seq_HELA_Human2.48540008
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.46004477
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37096470
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.37029880
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34839021
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31153944
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30709501
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22960380
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.19891778
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15878784
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15078470
26ZFP281_18757296_ChIP-ChIP_E14_Mouse2.13639097
27ZNF274_21170338_ChIP-Seq_K562_Hela2.10891368
28LXR_22292898_ChIP-Seq_THP-1_Human2.09309393
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05159089
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.97122323
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.97101546
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92118824
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80293469
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74017314
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.72678776
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.70553949
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62742573
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.59897168
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59083619
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55278792
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52774905
42KDM2B_26808549_Chip-Seq_K562_Human1.49344728
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49187694
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49068997
45* SMC4_20622854_ChIP-Seq_HELA_Human1.48256130
46AR_21572438_ChIP-Seq_LNCaP_Human1.47910748
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.47065020
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45591675
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.43597633
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.42282694
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40586278
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40109940
53RACK7_27058665_Chip-Seq_MCF-7_Human1.40049597
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38516320
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36641510
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36041516
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33231656
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31665627
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31280437
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30371160
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29161509
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28297109
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26993447
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26910229
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26008577
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25986813
67TP53_23651856_ChIP-Seq_MEFs_Mouse1.24962598
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24318977
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23820138
70* AR_19668381_ChIP-Seq_PC3_Human1.23313270
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22031763
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21865475
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20271346
74CREB1_26743006_Chip-Seq_LNCaP_Human1.18582876
75CLOCK_20551151_ChIP-Seq_293T_Human1.18451909
76SMAD4_21799915_ChIP-Seq_A2780_Human1.17247242
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16493460
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15124388
79P68_20966046_ChIP-Seq_HELA_Human1.14603798
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10842549
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10674543
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09971887
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09291154
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08758011
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08257264
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06828409
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.06442854
88SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05950789
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.05725413
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05521216
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05300941
92* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04994252
93CTCF_27219007_Chip-Seq_Bcells_Human1.04957447
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04536960
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.03680062
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03271071
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02919292
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02352877
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01912371
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.01045549
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00552477
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99715799
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99161259
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98929126
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98219865
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97457444
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97377849
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97185950
109* TBX20_22080862_ChIP-Seq_HEART_Mouse0.95607746
110* TBX20_22328084_ChIP-Seq_HEART_Mouse0.95607746
111IGF1R_20145208_ChIP-Seq_DFB_Human0.94778261
112* MITF_21258399_ChIP-Seq_MELANOMA_Human0.94644018
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.94187070
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.94165238
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93564291
116BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92424221
117KDM2B_26808549_Chip-Seq_DND41_Human0.92156398
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.91970388
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90230962
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90147604
121RNF2_27304074_Chip-Seq_NSC_Mouse0.90127472
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89610257
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88671895
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.87193720
125AR_25329375_ChIP-Seq_VCAP_Human0.86491044
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.85504447
127STAT3_23295773_ChIP-Seq_U87_Human0.85403083
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85146168
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.84587533
130ZNF263_19887448_ChIP-Seq_K562_Human0.83304024
131SOX9_26525672_Chip-Seq_HEART_Mouse0.82956974
132OCT4_19829295_ChIP-Seq_ESCs_Human0.82275898
133AHR_22903824_ChIP-Seq_MCF-7_Human0.81968447
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.81089231
135* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79411767
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.78913183
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78790492
138KLF4_19829295_ChIP-Seq_ESCs_Human0.78011283
139P300_19829295_ChIP-Seq_ESCs_Human0.77262600
140TCF4_23295773_ChIP-Seq_U87_Human0.75456286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.93934968
2MP0003880_abnormal_central_pattern3.76432527
3MP0003635_abnormal_synaptic_transmissio3.66841722
4MP0004270_analgesia3.60818253
5MP0002063_abnormal_learning/memory/cond2.84546186
6MP0009745_abnormal_behavioral_response2.76255193
7MP0002064_seizures2.59345906
8MP0001968_abnormal_touch/_nociception2.37264034
9MP0002837_dystrophic_cardiac_calcinosis2.28454460
10MP0002572_abnormal_emotion/affect_behav2.28169828
11MP0002734_abnormal_mechanical_nocicepti2.27951011
12MP0009046_muscle_twitch2.26229445
13MP0000751_myopathy2.23244997
14MP0000778_abnormal_nervous_system2.04975062
15MP0002272_abnormal_nervous_system2.02796413
16MP0005423_abnormal_somatic_nervous1.99778486
17MP0004145_abnormal_muscle_electrophysio1.92377807
18MP0002909_abnormal_adrenal_gland1.89646172
19MP0002822_catalepsy1.88967478
20MP0001486_abnormal_startle_reflex1.88908665
21MP0002736_abnormal_nociception_after1.86721653
22MP0002184_abnormal_innervation1.85387197
23MP0004233_abnormal_muscle_weight1.83230433
24MP0004811_abnormal_neuron_physiology1.73736855
25MP0002733_abnormal_thermal_nociception1.67018037
26MP0004858_abnormal_nervous_system1.65393145
27MP0008569_lethality_at_weaning1.60956233
28MP0001440_abnormal_grooming_behavior1.59499982
29MP0000955_abnormal_spinal_cord1.57214558
30MP0002735_abnormal_chemical_nociception1.57210377
31MP0002067_abnormal_sensory_capabilities1.55929203
32MP0001970_abnormal_pain_threshold1.55559014
33MP0000569_abnormal_digit_pigmentation1.54736740
34MP0002557_abnormal_social/conspecific_i1.53398319
35MP0005171_absent_coat_pigmentation1.43551728
36MP0006292_abnormal_olfactory_placode1.43230740
37MP0003137_abnormal_impulse_conducting1.42934354
38MP0005386_behavior/neurological_phenoty1.41843890
39MP0004924_abnormal_behavior1.41843890
40MP0003787_abnormal_imprinting1.40356796
41MP0002234_abnormal_pharynx_morphology1.39982259
42MP0003705_abnormal_hypodermis_morpholog1.39442868
43MP0003646_muscle_fatigue1.38495014
44MP0002638_abnormal_pupillary_reflex1.38004940
45MP0002882_abnormal_neuron_morphology1.35948800
46MP0003122_maternal_imprinting1.35660076
47MP0001501_abnormal_sleep_pattern1.32534277
48MP0002653_abnormal_ependyma_morphology1.30986452
49MP0004215_abnormal_myocardial_fiber1.29679684
50MP0003329_amyloid_beta_deposits1.28758570
51MP0002066_abnormal_motor_capabilities/c1.28418595
52MP0004885_abnormal_endolymph1.28136206
53MP0004084_abnormal_cardiac_muscle1.27988631
54MP0003634_abnormal_glial_cell1.26537746
55MP0009780_abnormal_chondrocyte_physiolo1.25078019
56MP0006276_abnormal_autonomic_nervous1.24935342
57MP0008438_abnormal_cutaneous_collagen1.24780050
58MP0000920_abnormal_myelination1.23651308
59MP0002152_abnormal_brain_morphology1.23070111
60MP0003690_abnormal_glial_cell1.22801878
61MP0004036_abnormal_muscle_relaxation1.21987770
62MP0005409_darkened_coat_color1.21964563
63MP0000749_muscle_degeneration1.21711548
64MP0000013_abnormal_adipose_tissue1.20062514
65MP0005646_abnormal_pituitary_gland1.18476166
66MP0000747_muscle_weakness1.17166195
67MP0001177_atelectasis1.11935151
68MP0004085_abnormal_heartbeat1.11275344
69MP0001529_abnormal_vocalization1.09780161
70MP0001502_abnormal_circadian_rhythm1.09677437
71MP0008260_abnormal_autophagy1.08678409
72MP0000631_abnormal_neuroendocrine_gland1.05549254
73MP0004130_abnormal_muscle_cell1.04569879
74MP0000604_amyloidosis1.03450279
75MP0001346_abnormal_lacrimal_gland1.03267838
76MP0004087_abnormal_muscle_fiber1.02355040
77MP0003879_abnormal_hair_cell1.01377787
78MP0010386_abnormal_urinary_bladder1.01286238
79MP0003123_paternal_imprinting0.99884255
80MP0001348_abnormal_lacrimal_gland0.99414507
81MP0005620_abnormal_muscle_contractility0.96740948
82MP0004142_abnormal_muscle_tone0.95767642
83MP0003861_abnormal_nervous_system0.94897548
84MP0000537_abnormal_urethra_morphology0.94786764
85MP0002106_abnormal_muscle_physiology0.93925818
86MP0000579_abnormal_nail_morphology0.93820368
87MP0001958_emphysema0.93564308
88MP0003283_abnormal_digestive_organ0.93234549
89MP0000759_abnormal_skeletal_muscle0.93163928
90MP0005645_abnormal_hypothalamus_physiol0.89252851
91MP0001905_abnormal_dopamine_level0.89075969
92MP0003385_abnormal_body_wall0.88066874
93MP0005394_taste/olfaction_phenotype0.87529094
94MP0005499_abnormal_olfactory_system0.87529094
95MP0004510_myositis0.86987758
96MP0003119_abnormal_digestive_system0.86284122
97MP0002332_abnormal_exercise_endurance0.84167103
98MP0002269_muscular_atrophy0.82815594
99MP0002972_abnormal_cardiac_muscle0.82581067
100MP0005187_abnormal_penis_morphology0.81359617
101MP0003633_abnormal_nervous_system0.81356488
102MP0001984_abnormal_olfaction0.81056820
103MP0008961_abnormal_basal_metabolism0.79726109
104MP0003632_abnormal_nervous_system0.79576200
105MP0002069_abnormal_eating/drinking_beha0.79195890
106MP0004484_altered_response_of0.78623293
107MP0001849_ear_inflammation0.78487304
108MP0001299_abnormal_eye_distance/0.78155280
109MP0001485_abnormal_pinna_reflex0.78047230
110MP0002877_abnormal_melanocyte_morpholog0.77717318
111MP0005623_abnormal_meninges_morphology0.77704147
112MP0005330_cardiomyopathy0.77057109
113MP0003631_nervous_system_phenotype0.76215482
114MP0000750_abnormal_muscle_regeneration0.76071612
115MP0005369_muscle_phenotype0.75710595
116MP0001188_hyperpigmentation0.74758275
117MP0003121_genomic_imprinting0.74314177
118MP0002127_abnormal_cardiovascular_syste0.74038256
119MP0002752_abnormal_somatic_nervous0.72808498
120MP0002229_neurodegeneration0.72797633
121MP0009840_abnormal_foam_cell0.69307005
122MP0010234_abnormal_vibrissa_follicle0.69148411
123MP0003566_abnormal_cell_adhesion0.67128070
124MP0002249_abnormal_larynx_morphology0.65104080
125MP0008874_decreased_physiological_sensi0.64275731
126MP0003172_abnormal_lysosome_physiology0.63996300
127MP0005670_abnormal_white_adipose0.63243383
128MP0010769_abnormal_survival0.62650082
129MP0003075_altered_response_to0.62477968
130MP0000003_abnormal_adipose_tissue0.61778126
131MP0001943_abnormal_respiration0.60804239
132MP0000462_abnormal_digestive_system0.58999331
133MP0010768_mortality/aging0.58511699
134MP0001963_abnormal_hearing_physiology0.57955658

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.17671383
2Myokymia (HP:0002411)5.01218582
3Visual hallucinations (HP:0002367)4.18189451
4Focal seizures (HP:0007359)3.93323174
5Epileptic encephalopathy (HP:0200134)3.44705826
6Abnormality of the lower motor neuron (HP:0002366)3.37626543
7Upper limb amyotrophy (HP:0009129)3.20101246
8Distal upper limb amyotrophy (HP:0007149)3.20101246
9Poor eye contact (HP:0000817)3.19678593
10Hand muscle atrophy (HP:0009130)3.17718971
11Atonic seizures (HP:0010819)3.17174982
12Neurofibrillary tangles (HP:0002185)3.13500786
13Broad-based gait (HP:0002136)3.11426570
14Cerebral hypomyelination (HP:0006808)2.93675334
15Shoulder girdle muscle weakness (HP:0003547)2.89115978
16Sudden death (HP:0001699)2.88467275
17Supranuclear gaze palsy (HP:0000605)2.85231783
18Ankle clonus (HP:0011448)2.82885293
19Impaired social interactions (HP:0000735)2.82803341
20Abnormal social behavior (HP:0012433)2.82803341
21Absence seizures (HP:0002121)2.81602320
22Progressive cerebellar ataxia (HP:0002073)2.81027310
23Generalized tonic-clonic seizures (HP:0002069)2.79091452
24Impaired vibration sensation in the lower limbs (HP:0002166)2.77669094
25Depression (HP:0000716)2.74241116
26Akinesia (HP:0002304)2.63969430
27Action tremor (HP:0002345)2.61070307
28Diplopia (HP:0000651)2.60511977
29Abnormality of binocular vision (HP:0011514)2.60511977
30Febrile seizures (HP:0002373)2.59728106
31Insomnia (HP:0100785)2.56730382
32Dysdiadochokinesis (HP:0002075)2.55831121
33Torticollis (HP:0000473)2.53239894
34Anxiety (HP:0000739)2.49512527
35Urinary urgency (HP:0000012)2.49272068
36Exercise-induced myalgia (HP:0003738)2.48707975
37Dialeptic seizures (HP:0011146)2.47397743
38Pointed chin (HP:0000307)2.46994943
39Urinary bladder sphincter dysfunction (HP:0002839)2.45506632
40Abnormal gallbladder physiology (HP:0012438)2.44411252
41Cholecystitis (HP:0001082)2.44411252
42Achilles tendon contracture (HP:0001771)2.41721056
43Ventricular fibrillation (HP:0001663)2.41324417
44Distal lower limb amyotrophy (HP:0008944)2.40810773
45Bundle branch block (HP:0011710)2.40712357
46Papilledema (HP:0001085)2.40633554
47Megalencephaly (HP:0001355)2.40219937
48Tetraplegia (HP:0002445)2.30262132
49Difficulty climbing stairs (HP:0003551)2.26534584
50Type 1 muscle fiber predominance (HP:0003803)2.26268462
51Amyotrophic lateral sclerosis (HP:0007354)2.26163451
52Impaired smooth pursuit (HP:0007772)2.25634880
53Peripheral hypomyelination (HP:0007182)2.25268948
54Deep palmar crease (HP:0006191)2.25177458
55Prolonged QT interval (HP:0001657)2.21723416
56Exercise-induced muscle cramps (HP:0003710)2.20021581
57Dysmetria (HP:0001310)2.18532184
58Limb dystonia (HP:0002451)2.17748328
59Intention tremor (HP:0002080)2.17468000
60Truncal ataxia (HP:0002078)2.17431338
61Obstructive sleep apnea (HP:0002870)2.17332651
62Neuronal loss in central nervous system (HP:0002529)2.15212671
63Foot dorsiflexor weakness (HP:0009027)2.15160546
64Muscle hypertrophy of the lower extremities (HP:0008968)2.14443659
65Abnormal eating behavior (HP:0100738)2.13912700
66Epileptiform EEG discharges (HP:0011182)2.13769634
67Rapidly progressive (HP:0003678)2.13376538
68Clonus (HP:0002169)2.12858909
69Amblyopia (HP:0000646)2.12839677
70Gaze-evoked nystagmus (HP:0000640)2.12467121
71Lower limb amyotrophy (HP:0007210)2.12339012
72Annular pancreas (HP:0001734)2.11830394
73Delusions (HP:0000746)2.11746773
74Calf muscle hypertrophy (HP:0008981)2.10956340
75EEG with generalized epileptiform discharges (HP:0011198)2.10083053
76Abnormality of the calf musculature (HP:0001430)2.10049331
77Hammertoe (HP:0001765)2.08953867
78Abnormal EKG (HP:0003115)2.08008233
79Postural instability (HP:0002172)2.07613273
80Turricephaly (HP:0000262)2.06666149
81Rimmed vacuoles (HP:0003805)2.06551540
82Increased connective tissue (HP:0009025)2.05474009
83Abnormality of the Achilles tendon (HP:0005109)2.05233814
84Neoplasm of the peripheral nervous system (HP:0100007)2.05207456
85Hemiparesis (HP:0001269)2.04679520
86EMG: myopathic abnormalities (HP:0003458)2.03859103
87Apathy (HP:0000741)2.03545001
88Bradykinesia (HP:0002067)2.02735400
89Muscle fiber inclusion bodies (HP:0100299)2.02455701
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02318459
91Mutism (HP:0002300)2.02001824
92Nemaline bodies (HP:0003798)2.01703590
93Abnormality of the foot musculature (HP:0001436)2.01159610
94Hyporeflexia of lower limbs (HP:0002600)2.01125130
95CNS hypomyelination (HP:0003429)2.00746799
96Aplasia involving bones of the extremities (HP:0009825)2.00592723
97Aplasia involving bones of the upper limbs (HP:0009823)2.00592723
98Aplasia of the phalanges of the hand (HP:0009802)2.00592723
99Abnormal atrioventricular conduction (HP:0005150)2.00584469
100Primary atrial arrhythmia (HP:0001692)2.00553386
101Spastic gait (HP:0002064)1.99810031
102Shallow orbits (HP:0000586)1.98531040
103Slow progression (HP:0003677)1.98309804
104Genetic anticipation (HP:0003743)1.97566447
105Hypsarrhythmia (HP:0002521)1.97319331
106Stereotypic behavior (HP:0000733)1.97029157
107Hypoplasia of the brainstem (HP:0002365)1.95727077
108Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95727077
109Excessive salivation (HP:0003781)1.95490940
110Drooling (HP:0002307)1.95490940
111Spinal rigidity (HP:0003306)1.93506577
112Cerebral inclusion bodies (HP:0100314)1.93298813
113Pelvic girdle muscle weakness (HP:0003749)1.93001092
114Distal sensory impairment (HP:0002936)1.92732214
115Atrial fibrillation (HP:0005110)1.92598173
116Distal lower limb muscle weakness (HP:0009053)1.92506874
117Cerebral aneurysm (HP:0004944)1.91888600
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91862877
119Hyperacusis (HP:0010780)1.91782207
120Limb-girdle muscle atrophy (HP:0003797)1.90596470
121Myotonia (HP:0002486)1.90519806
122Supraventricular tachycardia (HP:0004755)1.90107192
123Lower limb muscle weakness (HP:0007340)1.89921435
124Bowel incontinence (HP:0002607)1.89195668
125Neoplasm of the heart (HP:0100544)1.89083766
126Agitation (HP:0000713)1.88242920
127Stridor (HP:0010307)1.88021432
128Premature rupture of membranes (HP:0001788)1.87974196
129Atrioventricular block (HP:0001678)1.86827866
130Pheochromocytoma (HP:0002666)1.86616589
131Abnormality of the hip-girdle musculature (HP:0001445)1.86335765
132Abnormality of the musculature of the pelvis (HP:0001469)1.86335765
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.86236108
134Supraventricular arrhythmia (HP:0005115)1.85733583
135Increased variability in muscle fiber diameter (HP:0003557)1.84008598
136Fetal akinesia sequence (HP:0001989)1.83905932
137Resting tremor (HP:0002322)1.83510406
138Abnormality of ocular smooth pursuit (HP:0000617)1.83037160
139Dysmetric saccades (HP:0000641)1.82988110
140Myopathic facies (HP:0002058)1.82819117
141Ependymoma (HP:0002888)1.82049814
142Heart block (HP:0012722)1.81835664
143Heterochromia iridis (HP:0001100)1.80985602
144Focal dystonia (HP:0004373)1.80081359
145Spastic tetraparesis (HP:0001285)1.77448323
146Diminished motivation (HP:0000745)1.76174765
147Syncope (HP:0001279)1.75927487
148Truncus arteriosus (HP:0001660)1.75897347
149Insidious onset (HP:0003587)1.74516140
150Termporal pattern (HP:0011008)1.74516140
151Hyperventilation (HP:0002883)1.72297803
152Absent speech (HP:0001344)1.71343649
153Abnormality of skeletal muscle fiber size (HP:0012084)1.70174929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.02454737
2MAP3K93.81038222
3NTRK33.40085403
4MARK13.28000192
5MAP3K42.84499722
6MINK12.67655591
7PRKD32.58889902
8PAK62.56486856
9MAP2K72.54517751
10KSR22.43492507
11KSR12.05635147
12DAPK22.01020254
13NTRK21.86960803
14LIMK11.83342345
15TESK11.75262600
16PRPF4B1.69778391
17MAP2K41.62827157
18UHMK11.62702666
19PHKG11.61577790
20PHKG21.61577790
21PTK21.46803230
22CDK191.46542432
23PNCK1.41851654
24CASK1.40885030
25NEK11.40149390
26CDK51.39062210
27ALK1.35122451
28NTRK11.34186909
29CAMKK11.28604106
30NME11.25693550
31MAPK131.24610655
32STK381.21233864
33LATS21.19067185
34MAP3K121.12531196
35MAPK121.09313264
36PLK21.08809501
37ARAF1.08698895
38CDC42BPA1.07140087
39DAPK11.05293998
40SIK21.05219724
41CDK151.02720879
42CAMK2G1.02622805
43PRKCG1.02497956
44CDK181.01426615
45TYRO31.01270775
46CCNB11.01181573
47GRK51.01162159
48CDK141.00741237
49PRKCH0.98393164
50FES0.97793681
51PAK30.95873539
52EPHA20.92469189
53CDK11A0.91868775
54RET0.91802357
55MARK20.88775968
56NEK60.87291789
57LMTK20.85151052
58STK110.83304541
59INSRR0.81548748
60MAP3K20.79625705
61TNIK0.77619274
62MOS0.76174694
63RAF10.74459502
64CAMK2A0.73544846
65PKN10.73306071
66EPHB20.72597189
67MAP3K70.72401375
68DMPK0.72378098
69ROCK20.71517719
70CAMK10.71407767
71TTN0.71014570
72ERBB30.70856682
73FER0.70491862
74MET0.70447357
75OBSCN0.67837572
76RPS6KA20.67027807
77CSNK1G20.67007823
78RIPK10.65317558
79RIPK40.64738295
80DAPK30.64718211
81BRAF0.61861215
82MAP3K130.61565149
83PDGFRA0.60095167
84CAMK2B0.59483770
85MAP3K10.58408226
86BRSK10.56929490
87PRKD20.54600571
88TAOK10.54250303
89SMG10.54167024
90SGK2230.53621296
91SGK4940.53621296
92CAMK40.53523100
93BMPR20.52493044
94MST1R0.52465291
95WNK30.51107209
96PDK10.50930667
97RPS6KA30.48294571
98PAK40.47122189
99PKN20.47006880
100CAMK2D0.46667420
101EEF2K0.46575153
102SCYL20.45674001
103SGK10.44564810
104MAP2K10.43300978
105MTOR0.43084115
106SGK20.43009925
107EPHA30.42167038
108ICK0.41714902
109SGK30.40844651
110MKNK20.39292946
111CSNK1E0.39236941
112DYRK1A0.37828612
113FGFR40.37624329
114PRKCZ0.36834179
115MAP2K60.36696999
116MAPKAPK30.36094377
117CSNK1G30.36021219
118CSNK1A1L0.35590771
119TRIB30.34564697
120SIK10.34447998
121ROCK10.34396273
122MAPK100.34084466
123PDPK10.33928182
124PRKD10.33659102
125CAMKK20.33656471
126PTK2B0.33438116

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97230476
2Synaptic vesicle cycle_Homo sapiens_hsa047212.73576101
3Olfactory transduction_Homo sapiens_hsa047402.52134901
4Long-term potentiation_Homo sapiens_hsa047202.51300569
5Circadian entrainment_Homo sapiens_hsa047132.44388827
6GABAergic synapse_Homo sapiens_hsa047272.43130661
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37634730
8Glutamatergic synapse_Homo sapiens_hsa047242.29676400
9Morphine addiction_Homo sapiens_hsa050322.24640434
10Insulin secretion_Homo sapiens_hsa049112.13084129
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06426104
12Amphetamine addiction_Homo sapiens_hsa050312.05776286
13Dopaminergic synapse_Homo sapiens_hsa047282.04428089
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.86827776
15Cholinergic synapse_Homo sapiens_hsa047251.82701654
16Cardiac muscle contraction_Homo sapiens_hsa042601.77633554
17Taste transduction_Homo sapiens_hsa047421.75904773
18Gastric acid secretion_Homo sapiens_hsa049711.69840803
19Oxytocin signaling pathway_Homo sapiens_hsa049211.68908730
20Salivary secretion_Homo sapiens_hsa049701.68651343
21Serotonergic synapse_Homo sapiens_hsa047261.67731431
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58496839
23Vitamin B6 metabolism_Homo sapiens_hsa007501.56233781
24Dilated cardiomyopathy_Homo sapiens_hsa054141.54051452
25Long-term depression_Homo sapiens_hsa047301.52768731
26Cocaine addiction_Homo sapiens_hsa050301.48740835
27Renin secretion_Homo sapiens_hsa049241.47622870
28GnRH signaling pathway_Homo sapiens_hsa049121.47221970
29Gap junction_Homo sapiens_hsa045401.43520396
30Calcium signaling pathway_Homo sapiens_hsa040201.43357730
31Type II diabetes mellitus_Homo sapiens_hsa049301.40976636
32Axon guidance_Homo sapiens_hsa043601.32897792
33Oocyte meiosis_Homo sapiens_hsa041141.29610519
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29377680
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29240621
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.25591851
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25540146
38Glioma_Homo sapiens_hsa052141.21862503
39Melanogenesis_Homo sapiens_hsa049161.20378065
40Estrogen signaling pathway_Homo sapiens_hsa049151.19218227
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18032492
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16145694
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15771609
44cAMP signaling pathway_Homo sapiens_hsa040241.14067358
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13041038
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12038823
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09351071
48ErbB signaling pathway_Homo sapiens_hsa040121.09035343
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01066718
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96153419
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.95087865
52Biosynthesis of amino acids_Homo sapiens_hsa012300.94892435
53Arginine and proline metabolism_Homo sapiens_hsa003300.93851940
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91057356
55mTOR signaling pathway_Homo sapiens_hsa041500.86846236
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86721501
57AMPK signaling pathway_Homo sapiens_hsa041520.85807573
58Collecting duct acid secretion_Homo sapiens_hsa049660.85627491
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83301386
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82243902
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.82164860
62Bile secretion_Homo sapiens_hsa049760.82111512
63Vibrio cholerae infection_Homo sapiens_hsa051100.80759512
64Alzheimers disease_Homo sapiens_hsa050100.79571782
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.78701017
66MAPK signaling pathway_Homo sapiens_hsa040100.78082990
67VEGF signaling pathway_Homo sapiens_hsa043700.77769287
68Wnt signaling pathway_Homo sapiens_hsa043100.76360161
69Endometrial cancer_Homo sapiens_hsa052130.75964563
70Inositol phosphate metabolism_Homo sapiens_hsa005620.75452015
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75440512
72Glucagon signaling pathway_Homo sapiens_hsa049220.74772301
73Prion diseases_Homo sapiens_hsa050200.73966087
74Insulin signaling pathway_Homo sapiens_hsa049100.72393385
75Non-small cell lung cancer_Homo sapiens_hsa052230.72363251
76Choline metabolism in cancer_Homo sapiens_hsa052310.69973813
77Rap1 signaling pathway_Homo sapiens_hsa040150.69911757
78Arginine biosynthesis_Homo sapiens_hsa002200.69483462
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68109669
80Focal adhesion_Homo sapiens_hsa045100.64864988
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64459358
82Alcoholism_Homo sapiens_hsa050340.63676311
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63074264
84Parkinsons disease_Homo sapiens_hsa050120.62707607
85Pancreatic secretion_Homo sapiens_hsa049720.62546086
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62148152
87Colorectal cancer_Homo sapiens_hsa052100.61936403
88Ras signaling pathway_Homo sapiens_hsa040140.61903906
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.60948892
90Carbon metabolism_Homo sapiens_hsa012000.60935454
91Fructose and mannose metabolism_Homo sapiens_hsa000510.60803176
92Renal cell carcinoma_Homo sapiens_hsa052110.60558268
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58646009
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58348727
95Endocytosis_Homo sapiens_hsa041440.57835965
96Circadian rhythm_Homo sapiens_hsa047100.57455985
97Dorso-ventral axis formation_Homo sapiens_hsa043200.56271596
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55539301
99Nitrogen metabolism_Homo sapiens_hsa009100.55531373
100ECM-receptor interaction_Homo sapiens_hsa045120.52430677
101Tight junction_Homo sapiens_hsa045300.52206334
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49371460
103Thyroid hormone synthesis_Homo sapiens_hsa049180.48349568
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.48224741
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47544339
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47512035
107Melanoma_Homo sapiens_hsa052180.46833019
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46808971
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46375186
110Prolactin signaling pathway_Homo sapiens_hsa049170.46233836
111Oxidative phosphorylation_Homo sapiens_hsa001900.46226386
112Hippo signaling pathway_Homo sapiens_hsa043900.45953831
113Phenylalanine metabolism_Homo sapiens_hsa003600.45798735
114beta-Alanine metabolism_Homo sapiens_hsa004100.44975542
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.44827069
116HIF-1 signaling pathway_Homo sapiens_hsa040660.44260536
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43580659
118Huntingtons disease_Homo sapiens_hsa050160.42744821
119Hedgehog signaling pathway_Homo sapiens_hsa043400.42160798
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41943053
121Phototransduction_Homo sapiens_hsa047440.41910568
122Type I diabetes mellitus_Homo sapiens_hsa049400.41159067

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