NUCB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.63095805
2Golgi transport vesicle coating (GO:0048200)5.63095805
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46117791
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46117791
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.75945007
6antigen processing and presentation of endogenous antigen (GO:0019883)4.53891881
7protein retention in ER lumen (GO:0006621)4.39547353
8barbed-end actin filament capping (GO:0051016)3.85355306
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.73019374
10antigen processing and presentation via MHC class Ib (GO:0002475)3.69820660
11valine metabolic process (GO:0006573)3.64130229
12positive regulation of nuclease activity (GO:0032075)3.63150601
13negative regulation of erythrocyte differentiation (GO:0045647)3.50077782
14protein localization to endosome (GO:0036010)3.34486999
15pentose-phosphate shunt (GO:0006098)3.31934748
16endoplasmic reticulum unfolded protein response (GO:0030968)3.30458633
17regulation of nuclease activity (GO:0032069)3.26173815
18peptide catabolic process (GO:0043171)3.19701284
19cellular response to unfolded protein (GO:0034620)3.16845919
20COPII vesicle coating (GO:0048208)3.15827404
21mannose metabolic process (GO:0006013)3.13822596
22adhesion of symbiont to host (GO:0044406)3.13781626
23adhesion of symbiont to host cell (GO:0044650)3.11915121
24virion attachment to host cell (GO:0019062)3.11915121
25signal peptide processing (GO:0006465)3.11367062
26regulation of extracellular matrix disassembly (GO:0010715)3.11338527
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.09475353
28peptidyl-glutamic acid carboxylation (GO:0017187)3.05637084
29protein carboxylation (GO:0018214)3.05637084
30basement membrane organization (GO:0071711)3.03597331
314-hydroxyproline metabolic process (GO:0019471)3.02081076
32apoptotic cell clearance (GO:0043277)3.01393080
33ER-nucleus signaling pathway (GO:0006984)3.01160641
34regulation of early endosome to late endosome transport (GO:2000641)3.00940270
35pinocytosis (GO:0006907)2.99631256
36NADPH regeneration (GO:0006740)2.98681024
37sequestering of metal ion (GO:0051238)2.97717572
38cellular response to topologically incorrect protein (GO:0035967)2.96666036
39stress fiber assembly (GO:0043149)2.95767627
40positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.95759018
41positive regulation of histone deacetylation (GO:0031065)2.88901721
42sulfur amino acid catabolic process (GO:0000098)2.88832401
43glycosphingolipid catabolic process (GO:0046479)2.86199792
44UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83765686
45tricarboxylic acid metabolic process (GO:0072350)2.80898831
46alpha-linolenic acid metabolic process (GO:0036109)2.74261663
47regulation of cholesterol homeostasis (GO:2000188)2.72854120
48complement activation, alternative pathway (GO:0006957)2.71698740
49positive regulation of receptor recycling (GO:0001921)2.70727945
50positive regulation of lipoprotein lipase activity (GO:0051006)2.65582114
51positive regulation of triglyceride lipase activity (GO:0061365)2.65582114
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.63741158
53angiotensin maturation (GO:0002003)2.63045727
54response to endoplasmic reticulum stress (GO:0034976)2.61478163
55fibril organization (GO:0097435)2.61050328
56hyaluronan catabolic process (GO:0030214)2.60419119
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60283470
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.60029161
59glycolipid catabolic process (GO:0019377)2.56717521
60response to laminar fluid shear stress (GO:0034616)2.56340242
61cellular response to thyroid hormone stimulus (GO:0097067)2.56185258
62ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.55336964
63glucose catabolic process (GO:0006007)2.54670371
64exocrine pancreas development (GO:0031017)2.53348943
65positive regulation of triglyceride biosynthetic process (GO:0010867)2.50795206
66maternal placenta development (GO:0001893)2.50748420
67response to thyroid hormone (GO:0097066)2.49593006
68low-density lipoprotein particle clearance (GO:0034383)2.47020548
69L-alpha-amino acid transmembrane transport (GO:1902475)2.44836789
70intestinal cholesterol absorption (GO:0030299)2.44711305
71keratan sulfate catabolic process (GO:0042340)2.43718689
72extracellular fibril organization (GO:0043206)2.43520475
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43446689
74L-phenylalanine metabolic process (GO:0006558)2.43446689
75protein N-linked glycosylation via asparagine (GO:0018279)2.43417295
76peptidyl-asparagine modification (GO:0018196)2.42251885
77lysine catabolic process (GO:0006554)2.40885929
78lysine metabolic process (GO:0006553)2.40885929
792-oxoglutarate metabolic process (GO:0006103)2.40178989
80negative regulation of fibrinolysis (GO:0051918)2.39666686
81skin morphogenesis (GO:0043589)2.39407826
82regulation of complement activation (GO:0030449)2.39130976
83modulation by symbiont of host cellular process (GO:0044068)2.38818866
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.38338732
85regulation of protein activation cascade (GO:2000257)2.37300155
86protein autoprocessing (GO:0016540)2.37072080
87regulation of fatty acid beta-oxidation (GO:0031998)2.36187053
88regulation of membrane protein ectodomain proteolysis (GO:0051043)2.35999983
89hormone catabolic process (GO:0042447)2.35960018
90positive regulation of natural killer cell differentiation (GO:0032825)2.35837868
91positive regulation of protein deacetylation (GO:0090312)2.35524436
92positive regulation of triglyceride metabolic process (GO:0090208)2.34906614
93transcytosis (GO:0045056)2.34373695
94definitive hemopoiesis (GO:0060216)2.34196543
95amino sugar catabolic process (GO:0046348)2.34072783
96cysteine metabolic process (GO:0006534)2.33284960
97oxaloacetate metabolic process (GO:0006107)2.32998336
98vesicle coating (GO:0006901)2.32723919
99L-phenylalanine catabolic process (GO:0006559)2.32391584
100erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32391584
101regulation of extracellular matrix organization (GO:1903053)2.32109396
102glucose 6-phosphate metabolic process (GO:0051156)2.32039322
103response to unfolded protein (GO:0006986)2.31485688
104negative regulation of glycoprotein biosynthetic process (GO:0010561)2.30236180
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29137506
106positive regulation of extracellular matrix organization (GO:1903055)2.28972376
107NADH metabolic process (GO:0006734)2.28265750
108regulation of cholesterol storage (GO:0010885)2.28240622
109negative regulation of phagocytosis (GO:0050765)2.27749468
110positive regulation of Cdc42 GTPase activity (GO:0043089)2.27392226
111regulation of apoptotic cell clearance (GO:2000425)2.26447273
112triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.25871011
113defense response to fungus (GO:0050832)2.24951796
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.24168686
115detection of bacterium (GO:0016045)2.24041961
116negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23835638
117endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.23468756
118detection of other organism (GO:0098543)2.22838684
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.22763397
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.22002151
121negative regulation of cell killing (GO:0031342)2.22002151
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.21353733
123positive regulation of fatty acid biosynthetic process (GO:0045723)2.21300060
124activation of MAPKKK activity (GO:0000185)2.21041178
125protein N-linked glycosylation (GO:0006487)2.21006388
126response to topologically incorrect protein (GO:0035966)2.20978005
127response to peptidoglycan (GO:0032494)2.20808522
128endodermal cell differentiation (GO:0035987)2.20778305
129toxin transport (GO:1901998)2.20531596
130regulation of leukocyte degranulation (GO:0043300)2.19997999
131growth hormone receptor signaling pathway (GO:0060396)2.19123914
132positive regulation by symbiont of host defense response (GO:0052509)2.17648487
133modulation by symbiont of host defense response (GO:0052031)2.17648487
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.17648487
135modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.17648487
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.17648487
137modulation by symbiont of host immune response (GO:0052553)2.17648487
138cortical actin cytoskeleton organization (GO:0030866)2.17127050
139positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.17108344
140regulation of plasminogen activation (GO:0010755)2.16589900
141drug transmembrane transport (GO:0006855)2.16429675
142ethanol oxidation (GO:0006069)2.16332744
143negative regulation of fatty acid transport (GO:2000192)2.16051247
144regulation of macrophage chemotaxis (GO:0010758)2.15814440
145lipopolysaccharide-mediated signaling pathway (GO:0031663)2.15805854
146high-density lipoprotein particle remodeling (GO:0034375)2.15703776
147positive regulation of cholesterol efflux (GO:0010875)2.15288800
148negative regulation of lipid transport (GO:0032369)2.15164651
149fatty acid beta-oxidation (GO:0006635)2.15036339
150hexose catabolic process (GO:0019320)2.14891867
151detection of external biotic stimulus (GO:0098581)2.14212729
152positive regulation of phagocytosis (GO:0050766)2.13765574
153epithelial cell differentiation involved in prostate gland development (GO:0060742)2.13612985
154vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.13362977
155endothelial cell chemotaxis (GO:0035767)2.13353518
156positive regulation of endothelial cell apoptotic process (GO:2000353)2.12573643
157regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.12063043
158regulation of T-helper 2 cell differentiation (GO:0045628)2.12042501
159positive regulation of fatty acid beta-oxidation (GO:0032000)2.11950882
160positive regulation of cellular amide metabolic process (GO:0034250)2.11947736
161surfactant homeostasis (GO:0043129)2.11801961
162regulation of erythrocyte differentiation (GO:0045646)2.11639497
163venous blood vessel morphogenesis (GO:0048845)2.11127728
164cell-substrate junction assembly (GO:0007044)2.10768757
165cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.10560266
166adherens junction assembly (GO:0034333)2.09910409
167epithelial cell-cell adhesion (GO:0090136)2.09756089
168regulation of glucose import in response to insulin stimulus (GO:2001273)2.09685720
169vascular endothelial growth factor signaling pathway (GO:0038084)2.09596388
170ceramide catabolic process (GO:0046514)2.06968469
171embryo implantation (GO:0007566)2.06886655
172oligosaccharide catabolic process (GO:0009313)2.05686356
173detection of molecule of bacterial origin (GO:0032490)2.04578147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.36035980
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50390120
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.18687252
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.03892594
5GATA1_22025678_ChIP-Seq_K562_Human2.70941722
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.66987633
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.46828795
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.37163561
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.30295553
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29546744
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23522943
12SCL_19346495_ChIP-Seq_HPC-7_Human2.23065622
13CLOCK_20551151_ChIP-Seq_293T_Human2.20083540
14VDR_21846776_ChIP-Seq_THP-1_Human2.19793748
15MYC_22102868_ChIP-Seq_BL_Human2.17604357
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15073938
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13544524
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07615449
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05420291
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03095139
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.86978630
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.85850650
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81113094
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78626956
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78048453
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76760733
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74307053
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71272238
29VDR_24763502_ChIP-Seq_THP-1_Human1.70940635
30LXR_22292898_ChIP-Seq_THP-1_Human1.66017323
31TCF7_22412390_ChIP-Seq_EML_Mouse1.66007959
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63897005
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61669034
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.60913370
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60210680
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59967966
37KDM2B_26808549_Chip-Seq_K562_Human1.58629969
38* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56282731
39* MAF_26560356_Chip-Seq_TH1_Human1.55002247
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54058862
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51041316
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50063339
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.47844083
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46254988
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46157294
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44860173
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43260538
48UTX_26944678_Chip-Seq_JUKART_Human1.43148003
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42614461
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42174231
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40263589
52* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39989021
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39556995
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39154883
55RACK7_27058665_Chip-Seq_MCF-7_Human1.38596550
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38195662
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37719089
58GATA1_19941826_ChIP-Seq_K562_Human1.37648760
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35387002
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35228309
61* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35059698
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35021731
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.34852204
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.34068296
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34046167
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33885230
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32635983
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32263231
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31665422
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29665405
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29636181
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29406407
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29330851
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29020914
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.28764629
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27314799
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27312733
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.26186462
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.25302495
80P68_20966046_ChIP-Seq_HELA_Human1.24250210
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.24036556
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23547227
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23452216
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.23203948
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22721376
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22496154
87MYB_26560356_Chip-Seq_TH2_Human1.22398241
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21684597
89ATF3_27146783_Chip-Seq_COLON_Human1.21271128
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20070353
91SMC4_20622854_ChIP-Seq_HELA_Human1.19900958
92* SPI1_23547873_ChIP-Seq_NB4_Human1.19756197
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19652473
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19207148
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19164121
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.18816518
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18406776
98NCOR1_26117541_ChIP-Seq_K562_Human1.18330941
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17954911
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.17596038
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17389770
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16649553
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16596141
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14825130
105SPI1_23127762_ChIP-Seq_K562_Human1.14742604
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14553666
107KDM2B_26808549_Chip-Seq_DND41_Human1.14399340
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14364183
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14004596
110* MYB_26560356_Chip-Seq_TH1_Human1.12926493
111ZNF263_19887448_ChIP-Seq_K562_Human1.09568082
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.09089927
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.09089927
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09047368
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08754658
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08597128
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08575809
118BCOR_27268052_Chip-Seq_Bcells_Human1.08401209
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08235025
120GATA2_19941826_ChIP-Seq_K562_Human1.07225509
121SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06400733
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05158694
123* GATA6_25053715_ChIP-Seq_YYC3_Human1.04239373
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03826139
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02414705
126* CREB1_26743006_Chip-Seq_LNCaP_Human1.01752830
127GATA4_25053715_ChIP-Seq_YYC3_Human1.01166409
128MAF_26560356_Chip-Seq_TH2_Human1.01002795
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00805300
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00174043
131TFEB_21752829_ChIP-Seq_HELA_Human0.98228753
132IRF8_21731497_ChIP-ChIP_J774_Mouse0.98058701
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.97599743
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95504983
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95027728
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93887379
137* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93336255
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93302038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen2.94724977
2MP0003300_gastrointestinal_ulcer2.93835614
3MP0006054_spinal_hemorrhage2.87924683
4MP0002139_abnormal_hepatobiliary_system2.65148875
5MP0005360_urolithiasis2.44857127
6MP0005451_abnormal_body_composition2.40466105
7MP0003705_abnormal_hypodermis_morpholog2.33504462
8MP0005365_abnormal_bile_salt2.31917323
9MP0009840_abnormal_foam_cell2.24775971
10MP0005058_abnormal_lysosome_morphology2.13742343
11MP0002877_abnormal_melanocyte_morpholog2.12471505
12MP0003191_abnormal_cellular_cholesterol1.88847464
13MP0004858_abnormal_nervous_system1.78433237
14MP0005085_abnormal_gallbladder_physiolo1.78057945
15MP0003252_abnormal_bile_duct1.77760873
16MP0004510_myositis1.77154181
17MP0003566_abnormal_cell_adhesion1.75439250
18MP0003329_amyloid_beta_deposits1.75226954
19MP0005464_abnormal_platelet_physiology1.72677538
20MP0005257_abnormal_intraocular_pressure1.72284117
21MP0000604_amyloidosis1.71639484
22MP0008260_abnormal_autophagy1.71487431
23MP0001849_ear_inflammation1.65376109
24MP0003724_increased_susceptibility_to1.64159078
25MP0003091_abnormal_cell_migration1.63668380
26MP0003303_peritoneal_inflammation1.62747314
27MP0003075_altered_response_to1.62385440
28MP0010329_abnormal_lipoprotein_level1.61411929
29MP0001666_abnormal_nutrient_absorption1.60606073
30MP0003436_decreased_susceptibility_to1.57867088
31MP0005275_abnormal_skin_tensile1.57420579
32MP0005083_abnormal_biliary_tract1.54473262
33MP0002998_abnormal_bone_remodeling1.54213523
34MP0003656_abnormal_erythrocyte_physiolo1.54052243
35MP0000465_gastrointestinal_hemorrhage1.53900787
36MP0009643_abnormal_urine_homeostasis1.53851821
37MP0010368_abnormal_lymphatic_system1.53701730
38MP0005220_abnormal_exocrine_pancreas1.52409835
39MP0008875_abnormal_xenobiotic_pharmacok1.51545629
40MP0000751_myopathy1.45635023
41MP0003172_abnormal_lysosome_physiology1.40752481
42MP0000685_abnormal_immune_system1.38195960
43MP0003453_abnormal_keratinocyte_physiol1.36764286
44MP0002166_altered_tumor_susceptibility1.35528783
45MP0002396_abnormal_hematopoietic_system1.33109753
46MP0003279_aneurysm1.32590091
47MP0001533_abnormal_skeleton_physiology1.32260658
48MP0001545_abnormal_hematopoietic_system1.31043109
49MP0005397_hematopoietic_system_phenotyp1.31043109
50MP0005023_abnormal_wound_healing1.30862064
51MP0003183_abnormal_peptide_metabolism1.30605610
52MP0001958_emphysema1.28996532
53MP0000609_abnormal_liver_physiology1.28795499
54MP0002138_abnormal_hepatobiliary_system1.27585907
55MP0001835_abnormal_antigen_presentation1.26383698
56MP0010352_gastrointestinal_tract_polyps1.24659094
57MP0004264_abnormal_extraembryonic_tissu1.22695961
58MP0010155_abnormal_intestine_physiology1.22562291
59MP0004947_skin_inflammation1.20184005
60MP0002148_abnormal_hypersensitivity_rea1.19175935
61MP0005319_abnormal_enzyme/_coenzyme1.18004676
62MP0004272_abnormal_basement_membrane1.17335804
63MP0004808_abnormal_hematopoietic_stem1.14246583
64MP0001542_abnormal_bone_strength1.13110582
65MP0002419_abnormal_innate_immunity1.13085116
66MP0003828_pulmonary_edema1.11792584
67MP0009278_abnormal_bone_marrow1.11182936
68MP0003195_calcinosis1.11018437
69MP0003690_abnormal_glial_cell1.10642551
70MP0001873_stomach_inflammation1.10565659
71MP0005025_abnormal_response_to1.10393424
72MP0005165_increased_susceptibility_to1.10146838
73MP0008469_abnormal_protein_level1.08786507
74MP0005409_darkened_coat_color1.08199735
75MP0010234_abnormal_vibrissa_follicle1.07844469
76MP0001845_abnormal_inflammatory_respons1.06703184
77MP0002060_abnormal_skin_morphology1.06672320
78MP0003448_altered_tumor_morphology1.06456652
79MP0005166_decreased_susceptibility_to1.05347260
80MP0005076_abnormal_cell_differentiation1.05324213
81MP0000678_abnormal_parathyroid_gland1.05166529
82MP0008004_abnormal_stomach_pH1.04800122
83MP0000343_altered_response_to1.04580935
84MP0002254_reproductive_system_inflammat1.03731816
85MP0005666_abnormal_adipose_tissue1.03209071
86MP0005332_abnormal_amino_acid1.02681180
87MP0001756_abnormal_urination1.01764396
88MP0000598_abnormal_liver_morphology1.01522859
89MP0003866_abnormal_defecation1.00417565
90MP0000013_abnormal_adipose_tissue0.99816008
91MP0000858_altered_metastatic_potential0.99329880
92MP0001944_abnormal_pancreas_morphology0.97413698
93MP0009384_cardiac_valve_regurgitation0.97033039
94MP0005164_abnormal_response_to0.96931655
95MP0005636_abnormal_mineral_homeostasis0.96515687
96MP0002933_joint_inflammation0.96191118
97MP0002118_abnormal_lipid_homeostasis0.95765857
98MP0000490_abnormal_crypts_of0.93000528
99MP0009785_altered_susceptibility_to0.92455522
100MP0005503_abnormal_tendon_morphology0.91869344
101MP0000249_abnormal_blood_vessel0.89994957
102MP0000747_muscle_weakness0.89621184
103MP0002136_abnormal_kidney_physiology0.89466431
104MP0001879_abnormal_lymphatic_vessel0.89324266
105MP0001790_abnormal_immune_system0.88728394
106MP0005387_immune_system_phenotype0.88728394
107MP0001765_abnormal_ion_homeostasis0.88229113
108MP0003806_abnormal_nucleotide_metabolis0.87436308
109MP0003868_abnormal_feces_composition0.85991359
110MP0009333_abnormal_splenocyte_physiolog0.85415004
111MP0006082_CNS_inflammation0.83119575
112MP0003186_abnormal_redox_activity0.82785986
113MP0003795_abnormal_bone_structure0.82758900
114MP0000003_abnormal_adipose_tissue0.81855906
115MP0001851_eye_inflammation0.81623244
116MP0000920_abnormal_myelination0.81556249
117MP0002295_abnormal_pulmonary_circulatio0.81245728
118MP0002405_respiratory_system_inflammati0.81100970
119MP0001915_intracranial_hemorrhage0.80981406
120MP0005000_abnormal_immune_tolerance0.80940199
121MP0004185_abnormal_adipocyte_glucose0.80886567
122MP0002896_abnormal_bone_mineralization0.80516962
123MP0005670_abnormal_white_adipose0.80266209
124MP0005595_abnormal_vascular_smooth0.79936769
125MP0002909_abnormal_adrenal_gland0.79659501
126MP0002723_abnormal_immune_serum0.79633437
127MP0002452_abnormal_antigen_presenting0.78905749
128MP0002135_abnormal_kidney_morphology0.78781695
129MP0004130_abnormal_muscle_cell0.78280088
130MP0005390_skeleton_phenotype0.77947499
131MP0009764_decreased_sensitivity_to0.77809486
132MP0002928_abnormal_bile_duct0.77757967
133MP0002971_abnormal_brown_adipose0.77630736
134MP0005375_adipose_tissue_phenotype0.77021232
135MP0002693_abnormal_pancreas_physiology0.75940203
136MP0009763_increased_sensitivity_to0.75745881
137MP0000767_abnormal_smooth_muscle0.75742430
138MP0005508_abnormal_skeleton_morphology0.75212151
139MP0002089_abnormal_postnatal_growth/wei0.75187422
140MP0001819_abnormal_immune_cell0.73580170
141MP0002420_abnormal_adaptive_immunity0.73221973
142MP0006138_congestive_heart_failure0.72614654
143MP0003634_abnormal_glial_cell0.72096603

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)3.80851930
2Abnormality of liposaccharide metabolism (HP:0010968)3.80851930
3Abnormality of glycosphingolipid metabolism (HP:0004343)3.80851930
4Protrusio acetabuli (HP:0003179)3.55519059
5Dysostosis multiplex (HP:0000943)3.49069396
6Urinary glycosaminoglycan excretion (HP:0003541)3.43816540
7Mucopolysacchariduria (HP:0008155)3.43816540
8Vacuolated lymphocytes (HP:0001922)3.20090294
9Abnormality of polysaccharide metabolism (HP:0011012)3.10937734
10Abnormality of glycosaminoglycan metabolism (HP:0004371)3.10937734
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.10937734
12Petechiae (HP:0000967)2.96910262
13Abnormal platelet function (HP:0011869)2.93489177
14Impaired platelet aggregation (HP:0003540)2.93489177
15Deep venous thrombosis (HP:0002625)2.91850651
16Hypoglycemic coma (HP:0001325)2.89847883
17Abnormality of the intrinsic pathway (HP:0010989)2.89106839
18Cervical subluxation (HP:0003308)2.87516176
19Cerebral aneurysm (HP:0004944)2.80590852
20Increased connective tissue (HP:0009025)2.76736931
21Aortic aneurysm (HP:0004942)2.74146086
22Premature rupture of membranes (HP:0001788)2.72536732
23Thrombocytosis (HP:0001894)2.72126047
24Abnormality of the common coagulation pathway (HP:0010990)2.70618235
25Increased variability in muscle fiber diameter (HP:0003557)2.59717008
26Systemic lupus erythematosus (HP:0002725)2.57341754
27Abnormality of macrophages (HP:0004311)2.57065812
28Complement deficiency (HP:0004431)2.56896590
29Abnormality of the nasal mucosa (HP:0000433)2.53375036
30Menorrhagia (HP:0000132)2.51156170
31Beaking of vertebral bodies (HP:0004568)2.50989219
32Xanthomatosis (HP:0000991)2.50412888
33Peritonitis (HP:0002586)2.49396554
34Distal lower limb muscle weakness (HP:0009053)2.47406484
35Aortic dissection (HP:0002647)2.46113388
36Prolonged bleeding time (HP:0003010)2.44823793
37Neurofibrillary tangles (HP:0002185)2.43827765
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43571448
39Axonal loss (HP:0003447)2.42815170
40Loss of speech (HP:0002371)2.41956631
41Nonimmune hydrops fetalis (HP:0001790)2.41728103
42Interstitial pulmonary disease (HP:0006530)2.40330989
43Late onset (HP:0003584)2.38266117
44Abnormality of skeletal muscle fiber size (HP:0012084)2.35957261
45Nuclear cataract (HP:0100018)2.35807621
46Polycythemia (HP:0001901)2.32785660
47Achilles tendon contracture (HP:0001771)2.31375063
48Amyloidosis (HP:0011034)2.31242791
49Abnormality of complement system (HP:0005339)2.27851150
50Abnormality of the Achilles tendon (HP:0005109)2.27664986
51Hemorrhage of the eye (HP:0011885)2.26964804
52Epistaxis (HP:0000421)2.26629586
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26086337
54Distal lower limb amyotrophy (HP:0008944)2.22512421
55Increased cerebral lipofuscin (HP:0011813)2.22426487
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.22116567
57Intrahepatic cholestasis (HP:0001406)2.21407303
58Chronic otitis media (HP:0000389)2.20922248
59Spinal rigidity (HP:0003306)2.19908234
60Vertebral compression fractures (HP:0002953)2.19701903
61Nasal polyposis (HP:0100582)2.18665952
62Aneurysm (HP:0002617)2.16693269
63Spontaneous hematomas (HP:0007420)2.15849898
64Upper limb amyotrophy (HP:0009129)2.15340314
65Distal upper limb amyotrophy (HP:0007149)2.15340314
66Ankle contracture (HP:0006466)2.15157080
67Cerebral inclusion bodies (HP:0100314)2.14107403
68Abnormal platelet volume (HP:0011876)2.12602171
69Ketoacidosis (HP:0001993)2.11126183
70Wormian bones (HP:0002645)2.10118965
71Purpura (HP:0000979)2.09623159
72J-shaped sella turcica (HP:0002680)2.08842995
73Vascular tortuosity (HP:0004948)2.08537615
74Increased mean platelet volume (HP:0011877)2.08314925
75Gingival bleeding (HP:0000225)2.07086014
76Eczematoid dermatitis (HP:0000976)2.06715598
77Ketosis (HP:0001946)2.05951861
78Thoracic kyphosis (HP:0002942)2.05028770
79Type 1 muscle fiber predominance (HP:0003803)2.04086450
80Spondylolisthesis (HP:0003302)2.01106803
81Joint stiffness (HP:0001387)2.01073338
82Glomerulonephritis (HP:0000099)1.99641788
83Hypoglycemic seizures (HP:0002173)1.99094663
84Bladder diverticulum (HP:0000015)1.97197658
85Asymmetric septal hypertrophy (HP:0001670)1.96258769
86Cholecystitis (HP:0001082)1.94212225
87Abnormal gallbladder physiology (HP:0012438)1.94212225
88Mildly elevated creatine phosphokinase (HP:0008180)1.93622498
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.93156782
90Myocardial infarction (HP:0001658)1.93117222
91Joint hemorrhage (HP:0005261)1.92875198
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92399731
93Atrophic scars (HP:0001075)1.91384684
94Broad metatarsal (HP:0001783)1.90977888
95Hyperbilirubinemia (HP:0002904)1.90790804
96Recurrent gram-negative bacterial infections (HP:0005420)1.90622948
97Malnutrition (HP:0004395)1.90526320
98Arterial tortuosity (HP:0005116)1.89033953
99Hematochezia (HP:0002573)1.88672733
100Emphysema (HP:0002097)1.88214734
101Fragile skin (HP:0001030)1.87377568
102Abnormality of the lumbar spine (HP:0100712)1.87231006
103Shallow orbits (HP:0000586)1.87019102
104Ectopia lentis (HP:0001083)1.86334728
105Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85965559
106Abnormality of the thoracic spine (HP:0100711)1.85820341
107Generalized aminoaciduria (HP:0002909)1.85714854
108Ovoid vertebral bodies (HP:0003300)1.85173430
109Abdominal distention (HP:0003270)1.84949373
110Abnormality of fatty-acid metabolism (HP:0004359)1.84607854
111Cellulitis (HP:0100658)1.84263423
112Hypertriglyceridemia (HP:0002155)1.83657155
113Polygenic inheritance (HP:0010982)1.82773922
114Cardiomegaly (HP:0001640)1.81814043
115Hyperacusis (HP:0010780)1.81766680
116Thin bony cortex (HP:0002753)1.80487246
117Mitral stenosis (HP:0001718)1.79584807
118Mesangial abnormality (HP:0001966)1.79489800
119Genu recurvatum (HP:0002816)1.78777300
120Abnormality of the acetabulum (HP:0003170)1.77590770
121Severe short stature (HP:0003510)1.77107201
122Insulin resistance (HP:0000855)1.76854868
123Obstructive sleep apnea (HP:0002870)1.75677864
124Mitral valve prolapse (HP:0001634)1.75543910
125Gingivitis (HP:0000230)1.74603258
126Thoracolumbar scoliosis (HP:0002944)1.73493976
127Esophageal varix (HP:0002040)1.73024726
128Mitral regurgitation (HP:0001653)1.72539764
129Hyperinsulinemic hypoglycemia (HP:0000825)1.72220347
130Recurrent abscess formation (HP:0002722)1.71214880
131Slender build (HP:0001533)1.70988049
132Disproportionate tall stature (HP:0001519)1.70883825
133Radial bowing (HP:0002986)1.70557814
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.70262881
135Osteolytic defects of the hand bones (HP:0009699)1.70262881
136Nephritis (HP:0000123)1.69756839
137Elevated erythrocyte sedimentation rate (HP:0003565)1.69212362
138Hand muscle atrophy (HP:0009130)1.68816541
139Long toe (HP:0010511)1.68399706
140Segmental peripheral demyelination/remyelination (HP:0003481)1.67136337
141Bone pain (HP:0002653)1.66963762
142Prolonged partial thromboplastin time (HP:0003645)1.66202752
143Broad face (HP:0000283)1.66154817
144Abnormality of transition element cation homeostasis (HP:0011030)1.65767883
145Pathologic fracture (HP:0002756)1.64079091
146Biconcave vertebral bodies (HP:0004586)1.63973196
147Generalized amyotrophy (HP:0003700)1.62615567
148Protuberant abdomen (HP:0001538)1.62155864
149Increased serum ferritin (HP:0003281)1.61965695
150Blue sclerae (HP:0000592)1.61718466
151Dilatation of the ascending aorta (HP:0005111)1.61356906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.16784339
2TRIB34.10895070
3PKN23.17797786
4TAOK33.09559203
5PRPF4B3.00568483
6EEF2K2.81437153
7FLT32.13103505
8TGFBR22.09885019
9BCKDK2.06410527
10TAOK22.00564078
11SMG12.00478927
12PTK61.95643323
13SIK11.95148336
14ICK1.87012374
15LRRK21.84050362
16KDR1.74833300
17MAP4K11.72564454
18SCYL21.66231002
19MAP2K31.65572461
20MAPKAPK31.60737922
21RIPK41.56300197
22TBK11.53934782
23KIT1.52395726
24RIPK11.50076516
25EPHB11.49961250
26MAP3K131.49334411
27FGFR41.49036181
28PIK3CG1.48031846
29TIE11.47725472
30MAP3K101.46469882
31ZAP701.46171880
32JAK31.45332008
33TTN1.45299335
34CDC42BPA1.40954417
35MAPK151.35485694
36ARAF1.35443425
37PAK41.33106758
38TYK21.32831167
39BTK1.30658794
40PIM21.27196591
41TGFBR11.23308773
42MYLK1.19121138
43STK101.18915909
44PRKD21.18075270
45BLK1.17204176
46IRAK31.15695533
47PDGFRA1.15625155
48KSR21.15137637
49MOS1.09433646
50NME21.05965678
51FRK1.02185254
52MAP3K31.00854115
53PDPK10.99755191
54TEC0.99661842
55MARK20.98654754
56EPHA30.96211587
57PASK0.95671746
58MST1R0.95408153
59MAP3K140.94553096
60JAK10.93542554
61NEK90.93267862
62NTRK10.93139881
63INSRR0.92465972
64MAP2K20.91526317
65MAP3K110.91341958
66PTK20.90767225
67PAK20.90043543
68EPHB20.88507604
69MAP3K60.87683996
70JAK20.86838489
71RPS6KA40.86017650
72HIPK20.84214094
73RPS6KB20.83344097
74LATS20.83226580
75CDK120.81408227
76TESK10.79528718
77MAP3K10.79480726
78PRKG20.78878522
79MATK0.71342995
80MAPK120.70197137
81TRPM70.67859644
82MAPK70.67595697
83FES0.67411614
84CSF1R0.65164090
85ABL20.64531378
86ILK0.64210852
87IKBKE0.63913564
88ITK0.63763148
89CAMK1D0.63279676
90CDK60.63237799
91CSK0.63168936
92MAP3K70.62586832
93DYRK1B0.62469592
94BMX0.61541380
95LIMK10.61067383
96IRAK40.60886361
97FGR0.59612063
98PDK10.57668075
99MAPK110.56432125
100MTOR0.54179698
101STK380.53629555
102RET0.53509818
103GRK60.53082469
104TAOK10.52290783
105MAP3K80.52032895
106RPS6KA20.51970599
107FGFR30.49208537
108RPS6KA60.48314684
109LMTK20.46788659
110PRKD10.45878603
111SYK0.45857932
112TNK20.44228336
113PIM10.44104192
114RPS6KC10.43890967
115RPS6KL10.43890967
116MAPK40.43734954
117EPHA20.43285994
118HCK0.43269012
119MAPKAPK20.43059918
120CHUK0.41959834
121LATS10.41902457
122IKBKB0.41880876
123MAP3K20.41481982
124LCK0.41226194
125BRSK20.41209155
126DAPK30.41034488
127DDR20.40865079
128PDGFRB0.40578898
129DMPK0.38460529
130STK30.38218737
131TESK20.38086077
132MET0.37377926

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.49171224
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.49007741
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26556271
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.26035447
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.23881383
6Caffeine metabolism_Homo sapiens_hsa002322.15507461
7Complement and coagulation cascades_Homo sapiens_hsa046101.92032340
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.89004623
9Fatty acid degradation_Homo sapiens_hsa000711.85279186
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80813026
11Staphylococcus aureus infection_Homo sapiens_hsa051501.80230906
12N-Glycan biosynthesis_Homo sapiens_hsa005101.76712288
13Protein export_Homo sapiens_hsa030601.70722701
14Lysosome_Homo sapiens_hsa041421.65052597
15Tryptophan metabolism_Homo sapiens_hsa003801.64277177
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59460375
17Renin-angiotensin system_Homo sapiens_hsa046141.59046005
18Sulfur metabolism_Homo sapiens_hsa009201.58020806
19Selenocompound metabolism_Homo sapiens_hsa004501.56354920
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48738020
21Sulfur relay system_Homo sapiens_hsa041221.47461947
22Starch and sucrose metabolism_Homo sapiens_hsa005001.46236218
23ABC transporters_Homo sapiens_hsa020101.42595371
24Fat digestion and absorption_Homo sapiens_hsa049751.28597283
25Antigen processing and presentation_Homo sapiens_hsa046121.27660134
26Protein digestion and absorption_Homo sapiens_hsa049741.26243588
27PPAR signaling pathway_Homo sapiens_hsa033201.25976576
28Leishmaniasis_Homo sapiens_hsa051401.24914686
29Galactose metabolism_Homo sapiens_hsa000521.23132389
30ECM-receptor interaction_Homo sapiens_hsa045121.21717524
31Nitrogen metabolism_Homo sapiens_hsa009101.20982838
32Folate biosynthesis_Homo sapiens_hsa007901.20216339
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17185303
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15543902
35Arginine biosynthesis_Homo sapiens_hsa002201.06921188
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06878137
37VEGF signaling pathway_Homo sapiens_hsa043701.03935455
38Histidine metabolism_Homo sapiens_hsa003401.03752862
39Pentose phosphate pathway_Homo sapiens_hsa000301.00953366
40TNF signaling pathway_Homo sapiens_hsa046681.00507058
41Phagosome_Homo sapiens_hsa041451.00033322
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99882901
43Notch signaling pathway_Homo sapiens_hsa043300.99558244
44Peroxisome_Homo sapiens_hsa041460.97883227
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97840124
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97000063
47Legionellosis_Homo sapiens_hsa051340.96981852
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.96892671
49Toxoplasmosis_Homo sapiens_hsa051450.96694750
50Insulin resistance_Homo sapiens_hsa049310.96031398
51Amoebiasis_Homo sapiens_hsa051460.95155987
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94404624
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.93432814
54Bladder cancer_Homo sapiens_hsa052190.93388710
55Salmonella infection_Homo sapiens_hsa051320.93066475
56Lysine degradation_Homo sapiens_hsa003100.91671579
57Chronic myeloid leukemia_Homo sapiens_hsa052200.91552840
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91204276
59Fatty acid metabolism_Homo sapiens_hsa012120.90436361
60Hepatitis C_Homo sapiens_hsa051600.88281728
61Bile secretion_Homo sapiens_hsa049760.87397879
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84678839
63Small cell lung cancer_Homo sapiens_hsa052220.83546429
64Focal adhesion_Homo sapiens_hsa045100.83022014
65beta-Alanine metabolism_Homo sapiens_hsa004100.82924215
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82879333
67Acute myeloid leukemia_Homo sapiens_hsa052210.82309323
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.81495431
69Pertussis_Homo sapiens_hsa051330.81099437
70Hematopoietic cell lineage_Homo sapiens_hsa046400.80632639
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80506632
72Vibrio cholerae infection_Homo sapiens_hsa051100.80459041
73Platelet activation_Homo sapiens_hsa046110.80025345
74Phenylalanine metabolism_Homo sapiens_hsa003600.79922699
75Carbon metabolism_Homo sapiens_hsa012000.79200881
76Osteoclast differentiation_Homo sapiens_hsa043800.78202551
77Malaria_Homo sapiens_hsa051440.77847030
78Viral myocarditis_Homo sapiens_hsa054160.77531139
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76255127
80Propanoate metabolism_Homo sapiens_hsa006400.75917194
81Influenza A_Homo sapiens_hsa051640.75433900
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75349946
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.75325538
84Insulin signaling pathway_Homo sapiens_hsa049100.74305074
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.74088530
86Shigellosis_Homo sapiens_hsa051310.74079179
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73448611
88Endocytosis_Homo sapiens_hsa041440.73313950
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.72652743
90Non-small cell lung cancer_Homo sapiens_hsa052230.72389732
91Chemical carcinogenesis_Homo sapiens_hsa052040.71679881
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70786119
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.69400466
94GnRH signaling pathway_Homo sapiens_hsa049120.69143030
95Renal cell carcinoma_Homo sapiens_hsa052110.68249913
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68229294
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67252344
98Apoptosis_Homo sapiens_hsa042100.66449221
99Biosynthesis of amino acids_Homo sapiens_hsa012300.65006365
100Chemokine signaling pathway_Homo sapiens_hsa040620.64477854
101Rheumatoid arthritis_Homo sapiens_hsa053230.63773007
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63645365
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.61540430
104Hepatitis B_Homo sapiens_hsa051610.60994225
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60082234
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.60012983
107Allograft rejection_Homo sapiens_hsa053300.59166331
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58720153
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58014724
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.56120202
111HIF-1 signaling pathway_Homo sapiens_hsa040660.55179784
112Measles_Homo sapiens_hsa051620.55174778
113Endometrial cancer_Homo sapiens_hsa052130.54334656
114Glutathione metabolism_Homo sapiens_hsa004800.54077625
115Vitamin digestion and absorption_Homo sapiens_hsa049770.53766124
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53731308
117Autoimmune thyroid disease_Homo sapiens_hsa053200.53703562
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52963980
119Pancreatic cancer_Homo sapiens_hsa052120.52931082
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52810318
121Prolactin signaling pathway_Homo sapiens_hsa049170.52737071
122Thyroid cancer_Homo sapiens_hsa052160.51415261
123African trypanosomiasis_Homo sapiens_hsa051430.51378950
124Thyroid hormone synthesis_Homo sapiens_hsa049180.50840480
125Fructose and mannose metabolism_Homo sapiens_hsa000510.50610275
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49880083
127AMPK signaling pathway_Homo sapiens_hsa041520.49608966
128Dilated cardiomyopathy_Homo sapiens_hsa054140.48216140
129Sphingolipid metabolism_Homo sapiens_hsa006000.48042628
130One carbon pool by folate_Homo sapiens_hsa006700.47252842
131Pyruvate metabolism_Homo sapiens_hsa006200.47146298
132Tyrosine metabolism_Homo sapiens_hsa003500.46768757
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46528102
134Glioma_Homo sapiens_hsa052140.46246013
135Estrogen signaling pathway_Homo sapiens_hsa049150.46244602
136Graft-versus-host disease_Homo sapiens_hsa053320.46212140
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45777993
138Proteoglycans in cancer_Homo sapiens_hsa052050.45613718
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45271182
140Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45058400
141mTOR signaling pathway_Homo sapiens_hsa041500.44917718
142B cell receptor signaling pathway_Homo sapiens_hsa046620.43539246
143Tuberculosis_Homo sapiens_hsa051520.43237049
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43135849
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.42921119
146Prion diseases_Homo sapiens_hsa050200.42852967
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42598807

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