NUAK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.49503611
2negative regulation of cell killing (GO:0031342)6.49503611
3antigen processing and presentation of endogenous antigen (GO:0019883)5.10033295
4detection of other organism (GO:0098543)4.84732032
5detection of bacterium (GO:0016045)4.69299718
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.69263957
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69263957
8leukocyte migration involved in inflammatory response (GO:0002523)4.63147600
9radial glial cell differentiation (GO:0060019)4.54476207
10leukocyte aggregation (GO:0070486)4.44180705
11negative regulation of lymphocyte mediated immunity (GO:0002707)4.20323238
12NIK/NF-kappaB signaling (GO:0038061)4.12742570
13response to muramyl dipeptide (GO:0032495)4.04865655
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98599977
15neutrophil activation involved in immune response (GO:0002283)3.95069024
16detection of external biotic stimulus (GO:0098581)3.92771808
17response to interleukin-15 (GO:0070672)3.90698986
18response to peptidoglycan (GO:0032494)3.89485293
19regulation of gamma-delta T cell activation (GO:0046643)3.83180265
20cellular response to interleukin-15 (GO:0071350)3.80893974
21activated T cell proliferation (GO:0050798)3.80171876
22growth hormone receptor signaling pathway (GO:0060396)3.76698772
23response to host immune response (GO:0052572)3.74089900
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.74089900
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.73790619
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69007356
27response to host (GO:0075136)3.69007356
28response to host defenses (GO:0052200)3.69007356
29negative regulation of interleukin-12 production (GO:0032695)3.68693312
30microglial cell activation (GO:0001774)3.66570717
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.65493046
32detection of biotic stimulus (GO:0009595)3.62548052
33positive regulation of Notch signaling pathway (GO:0045747)3.57107906
34detection of molecule of bacterial origin (GO:0032490)3.56867615
35positive regulation of antigen processing and presentation (GO:0002579)3.54083037
36production of molecular mediator involved in inflammatory response (GO:0002532)3.53984207
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.52025945
38immunoglobulin mediated immune response (GO:0016064)3.47604410
39positive regulation of interferon-alpha production (GO:0032727)3.44528149
40myeloid cell activation involved in immune response (GO:0002275)3.44327586
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43547616
42negative regulation of T cell mediated immunity (GO:0002710)3.41611483
43negative regulation of leukocyte mediated immunity (GO:0002704)3.39125978
44neuron fate determination (GO:0048664)3.35653060
45regulation of T cell mediated cytotoxicity (GO:0001914)3.33956966
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.31211551
47neutrophil activation (GO:0042119)3.31024649
48neuronal stem cell maintenance (GO:0097150)3.30533590
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.30344463
50negative regulation of alpha-beta T cell activation (GO:0046636)3.29981317
51myeloid dendritic cell differentiation (GO:0043011)3.27177434
52macrophage activation (GO:0042116)3.25659652
53negative thymic T cell selection (GO:0045060)3.24682097
54regulation of antigen processing and presentation (GO:0002577)3.23505686
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22221690
56regulation of interferon-alpha production (GO:0032647)3.22053513
57regulation of interferon-beta biosynthetic process (GO:0045357)3.21791224
58negative T cell selection (GO:0043383)3.20678595
59myeloid dendritic cell activation (GO:0001773)3.20338438
60regulation of gamma-delta T cell differentiation (GO:0045586)3.18094922
61cellular response to growth hormone stimulus (GO:0071378)3.17396634
62granulocyte activation (GO:0036230)3.15825641
63negative regulation of interleukin-1 production (GO:0032692)3.14615214
64leukocyte degranulation (GO:0043299)3.13604873
65positive regulation by symbiont of host defense response (GO:0052509)3.12702330
66modulation by symbiont of host defense response (GO:0052031)3.12702330
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12702330
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12702330
69positive regulation by organism of defense response of other organism involved in symbiotic interact3.12702330
70modulation by symbiont of host immune response (GO:0052553)3.12702330
71tolerance induction (GO:0002507)3.12697067
72regulation of T cell tolerance induction (GO:0002664)3.05425362
73respiratory burst (GO:0045730)3.04218227
74regulation of RIG-I signaling pathway (GO:0039535)3.04123540
75negative regulation of interleukin-6 production (GO:0032715)3.01445812
76regulation of B cell receptor signaling pathway (GO:0050855)2.97915818
77dendritic cell differentiation (GO:0097028)2.96515034
78positive regulation of mast cell activation (GO:0033005)2.96285569
79interferon-gamma-mediated signaling pathway (GO:0060333)2.96262118
80auditory receptor cell differentiation (GO:0042491)2.94944554
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93714348
82negative regulation of glycoprotein biosynthetic process (GO:0010561)2.93487356
83negative regulation of cAMP-mediated signaling (GO:0043951)2.92533422
84response to type I interferon (GO:0034340)2.92434472
85JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.91079938
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89555773
87type I interferon signaling pathway (GO:0060337)2.89522443
88cellular response to type I interferon (GO:0071357)2.89522443
89regulation of tolerance induction (GO:0002643)2.87723413
90regulation of mast cell degranulation (GO:0043304)2.85748649
91neutrophil mediated immunity (GO:0002446)2.84915482
92viral transcription (GO:0019083)2.84717412
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83692716
94negative regulation of T-helper cell differentiation (GO:0045623)2.83692716
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83577324
96positive regulation of gamma-delta T cell activation (GO:0046645)2.81304482
97B cell mediated immunity (GO:0019724)2.80930323
98response to interferon-beta (GO:0035456)2.79400372
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78836468
100T cell homeostasis (GO:0043029)2.76749742
101regulation of mast cell activation (GO:0033003)2.76539608
102mature B cell differentiation (GO:0002335)2.76509144
103positive regulation of interleukin-12 production (GO:0032735)2.75834263
104positive regulation of interleukin-1 beta secretion (GO:0050718)2.74870151
105response to growth hormone (GO:0060416)2.74591338
106natural killer cell mediated immunity (GO:0002228)2.73299612
107natural killer cell mediated cytotoxicity (GO:0042267)2.73299612
108hepatocyte apoptotic process (GO:0097284)2.72467244
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71415983
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.71222304
111negative regulation of interleukin-1 beta production (GO:0032691)2.68894890
112leukocyte mediated cytotoxicity (GO:0001909)2.62614915
113aminoglycoside antibiotic metabolic process (GO:0030647)2.61992862
114urate metabolic process (GO:0046415)2.59708503
115regulation of B cell differentiation (GO:0045577)2.59045957
116translational termination (GO:0006415)2.58460361
117negative regulation of granulocyte differentiation (GO:0030853)2.58454811
118mature B cell differentiation involved in immune response (GO:0002313)2.57703119
119ribosomal small subunit assembly (GO:0000028)2.57618109
120T-helper 1 type immune response (GO:0042088)2.57244225
121cellular response to zinc ion (GO:0071294)2.56817267
122cellular extravasation (GO:0045123)2.56218228
123regulation of apoptotic process involved in morphogenesis (GO:1902337)2.55020844
124cytokine secretion (GO:0050663)2.54156770
125response to fungus (GO:0009620)2.54106105
126positive regulation of B cell differentiation (GO:0045579)2.53309737
127regulation of cellular extravasation (GO:0002691)2.52694042
128macrophage activation involved in immune response (GO:0002281)2.52548180
129positive regulation of natural killer cell differentiation (GO:0032825)2.51988974
130cellular response to interferon-beta (GO:0035458)2.51171015
131negative regulation of phagocytosis (GO:0050765)2.50998278
132regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.49875799
133positive regulation of interferon-beta production (GO:0032728)2.49315851
134defense response to protozoan (GO:0042832)2.46174151
135actin nucleation (GO:0045010)2.42763506
136antigen processing and presentation via MHC class Ib (GO:0002475)2.41650419
137cellular response to vitamin D (GO:0071305)2.40437759
138dendritic cell migration (GO:0036336)2.39716621
139pinocytosis (GO:0006907)2.38751341
140response to interferon-alpha (GO:0035455)2.38108332
141interferon-gamma secretion (GO:0072643)2.36948180
142peptide catabolic process (GO:0043171)2.36837132
143lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36675404
144myeloid leukocyte mediated immunity (GO:0002444)2.36319610
145regulation of interleukin-12 production (GO:0032655)2.35448611
146superoxide anion generation (GO:0042554)2.34931745
147negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.34664390
148toxin transport (GO:1901998)2.34191210
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.34171119
150dendritic cell chemotaxis (GO:0002407)2.33817886
151regulation of T-helper 1 cell differentiation (GO:0045625)2.33237464
152response to protozoan (GO:0001562)2.33225666
153regulation of necroptotic process (GO:0060544)2.31712274
154cellular response to exogenous dsRNA (GO:0071360)2.31309565
155B cell receptor signaling pathway (GO:0050853)2.30035950
156I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.28848748
157regulation of natural killer cell differentiation (GO:0032823)2.27718890
158regulation of type I interferon-mediated signaling pathway (GO:0060338)2.27301673
159protein targeting to ER (GO:0045047)2.26425634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.28019213
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.20886679
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.06005884
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.24336546
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.20911002
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.14179047
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03500972
8* IRF8_27001747_Chip-Seq_BMDM_Mouse2.99903005
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99743420
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96434929
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91240223
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78343663
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75842370
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.70892574
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64281745
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47310120
17VDR_21846776_ChIP-Seq_THP-1_Human2.43368136
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43019643
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41071728
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32400541
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29407862
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21339935
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13360265
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12988867
25SCL_19346495_ChIP-Seq_HPC-7_Human2.06589479
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06520835
27SPI1_23547873_ChIP-Seq_NB4_Human2.05492661
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01465743
29VDR_24763502_ChIP-Seq_THP-1_Human2.01000441
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.99923565
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98093067
32MAF_26560356_Chip-Seq_TH1_Human1.97194080
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90363802
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88569392
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88401289
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85811876
37MYB_26560356_Chip-Seq_TH2_Human1.85525841
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80922798
39MYC_22102868_ChIP-Seq_BL_Human1.71906896
40* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68332248
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.68196112
42* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67947521
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.66014603
44MYB_26560356_Chip-Seq_TH1_Human1.65124072
45EZH2_22144423_ChIP-Seq_EOC_Human1.64042899
46TCF7_22412390_ChIP-Seq_EML_Mouse1.63884923
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58655900
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58627444
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55856124
50KDM2B_26808549_Chip-Seq_DND41_Human1.55483322
51GATA3_26560356_Chip-Seq_TH2_Human1.55331534
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53387487
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.49003433
54RUNX_20019798_ChIP-Seq_JUKART_Human1.47934642
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44730542
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42273556
57UTX_26944678_Chip-Seq_JUKART_Human1.41333349
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39680035
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39612787
60* PU_27001747_Chip-Seq_BMDM_Mouse1.39543250
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.38969273
62GATA1_22025678_ChIP-Seq_K562_Human1.38678550
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.33576315
64BCL6_27268052_Chip-Seq_Bcells_Human1.33534961
65* CDX2_20551321_ChIP-Seq_CACO-2_Human1.31230274
66ZNF274_21170338_ChIP-Seq_K562_Hela1.30709236
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30296666
68* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30255252
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28792132
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28603378
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28588635
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28474062
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27364758
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.24959609
75SPI1_23127762_ChIP-Seq_K562_Human1.23493924
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22086132
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20060783
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19155957
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19107743
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18808488
81VDR_24787735_ChIP-Seq_THP-1_Human1.18119261
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18008687
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16977784
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15391081
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15012372
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15012372
87SA1_27219007_Chip-Seq_Bcells_Human1.13317066
88* LXR_22158963_ChIP-Seq_LIVER_Mouse1.13115468
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12749181
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12029382
91SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.11436712
92IRF1_19129219_ChIP-ChIP_H3396_Human1.10366189
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10161465
94MAF_26560356_Chip-Seq_TH2_Human1.10133266
95BCOR_27268052_Chip-Seq_Bcells_Human1.08217482
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07610153
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06065916
98SMRT_27268052_Chip-Seq_Bcells_Human1.04891831
99CLOCK_20551151_ChIP-Seq_293T_Human1.04093351
100* NANOG_20526341_ChIP-Seq_ESCs_Human1.03321145
101* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02571214
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00724173
103* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00356387
104* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00176335
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99890494
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99233218
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98964399
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98177416
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97877653
110* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97815347
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97381488
112TRIM28_21343339_ChIP-Seq_HEK293_Human0.97288401
113* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97119078
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.96222684
115* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95853921
116SOX2_20726797_ChIP-Seq_SW620_Human0.95119720
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93393553
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93281281
119RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92475668
120GATA3_27048872_Chip-Seq_THYMUS_Human0.92335410
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91981009
122* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91146590
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91011991
124* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90828959
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90295280
126GATA4_25053715_ChIP-Seq_YYC3_Human0.90274433
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.89760644
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89620696
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89561714
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89406520
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88689936
132RXR_22108803_ChIP-Seq_LS180_Human0.87029576
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.84593775
134KDM2B_26808549_Chip-Seq_K562_Human0.79737350
135SMC4_20622854_ChIP-Seq_HELA_Human0.78547240
136P300_27268052_Chip-Seq_Bcells_Human0.78420890
137GATA3_21867929_ChIP-Seq_TH1_Mouse0.78029713
138OCT4_19829295_ChIP-Seq_ESCs_Human0.77960971
139SPI1_20517297_ChIP-Seq_HL60_Human0.77920258
140CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77715140
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.77499440
142* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76472396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.52371200
2MP0003878_abnormal_ear_physiology3.92553104
3MP0005377_hearing/vestibular/ear_phenot3.92553104
4MP0002653_abnormal_ependyma_morphology3.67885793
5MP0001835_abnormal_antigen_presentation3.62960746
6MP0003436_decreased_susceptibility_to2.95186069
7MP0003303_peritoneal_inflammation2.70410646
8MP0000685_abnormal_immune_system2.58757839
9MP0009785_altered_susceptibility_to2.51050031
10MP0002148_abnormal_hypersensitivity_rea2.44328335
11MP0002132_abnormal_respiratory_system2.39615385
12MP0005248_abnormal_Harderian_gland2.38479431
13MP0006292_abnormal_olfactory_placode2.35484462
14MP0001790_abnormal_immune_system2.35351875
15MP0005387_immune_system_phenotype2.35351875
16MP0003724_increased_susceptibility_to2.34909576
17MP0005360_urolithiasis2.27727602
18MP0003300_gastrointestinal_ulcer2.26392099
19MP0005000_abnormal_immune_tolerance2.23311380
20MP0002419_abnormal_innate_immunity2.19251693
21MP0001800_abnormal_humoral_immune2.16078734
22MP0005025_abnormal_response_to2.14865852
23MP0002452_abnormal_antigen_presenting2.14330804
24MP0001853_heart_inflammation2.05632670
25MP0002166_altered_tumor_susceptibility2.02892782
26MP0005671_abnormal_response_to1.97182995
27MP0002254_reproductive_system_inflammat1.96221740
28MP0002723_abnormal_immune_serum1.92306218
29MP0004858_abnormal_nervous_system1.91475253
30MP0001819_abnormal_immune_cell1.80900045
31MP0002420_abnormal_adaptive_immunity1.79729995
32MP0009379_abnormal_foot_pigmentation1.75436191
33MP0010155_abnormal_intestine_physiology1.72143234
34MP0004947_skin_inflammation1.63024425
35MP0002006_tumorigenesis1.62149733
36MP0003191_abnormal_cellular_cholesterol1.60347417
37MP0001873_stomach_inflammation1.52964780
38MP0004381_abnormal_hair_follicle1.51840043
39MP0001845_abnormal_inflammatory_respons1.50961797
40MP0004510_myositis1.50546713
41MP0005464_abnormal_platelet_physiology1.47503451
42MP0005174_abnormal_tail_pigmentation1.46143133
43MP0005075_abnormal_melanosome_morpholog1.45365955
44MP0010352_gastrointestinal_tract_polyps1.44472826
45MP0002139_abnormal_hepatobiliary_system1.42596545
46MP0002405_respiratory_system_inflammati1.42586486
47MP0004133_heterotaxia1.41622864
48MP0003252_abnormal_bile_duct1.41127686
49MP0001533_abnormal_skeleton_physiology1.40073808
50MP0001986_abnormal_taste_sensitivity1.39860900
51MP0000716_abnormal_immune_system1.38648907
52MP0009764_decreased_sensitivity_to1.36374300
53MP0010234_abnormal_vibrissa_follicle1.36070352
54MP0008469_abnormal_protein_level1.35300357
55MP0003183_abnormal_peptide_metabolism1.35125931
56MP0002396_abnormal_hematopoietic_system1.32881551
57MP0002398_abnormal_bone_marrow1.30950678
58MP0003122_maternal_imprinting1.30491297
59MP0009643_abnormal_urine_homeostasis1.30442775
60MP0003787_abnormal_imprinting1.28955064
61MP0001293_anophthalmia1.28225463
62MP0005058_abnormal_lysosome_morphology1.27903461
63MP0002136_abnormal_kidney_physiology1.27440652
64* MP0000490_abnormal_crypts_of1.22852559
65MP0006082_CNS_inflammation1.22328671
66MP0010030_abnormal_orbit_morphology1.22173462
67MP0000858_altered_metastatic_potential1.21987268
68MP0000689_abnormal_spleen_morphology1.18838354
69MP0003453_abnormal_keratinocyte_physiol1.16813467
70MP0004019_abnormal_vitamin_homeostasis1.16600578
71MP0002429_abnormal_blood_cell1.16191668
72MP0000566_synostosis1.14469658
73MP0005084_abnormal_gallbladder_morpholo1.14139830
74MP0005076_abnormal_cell_differentiation1.13044491
75MP0004883_abnormal_blood_vessel1.12267023
76MP0009333_abnormal_splenocyte_physiolog1.11037211
77MP0008260_abnormal_autophagy1.11030614
78MP0001545_abnormal_hematopoietic_system1.09888640
79MP0005397_hematopoietic_system_phenotyp1.09888640
80MP0002277_abnormal_respiratory_mucosa1.09330986
81MP0002722_abnormal_immune_system1.09113202
82MP0005310_abnormal_salivary_gland1.08304062
83MP0003866_abnormal_defecation1.08012204
84MP0002928_abnormal_bile_duct1.07082120
85MP0003448_altered_tumor_morphology1.05933499
86MP0000703_abnormal_thymus_morphology1.03243763
87MP0002877_abnormal_melanocyte_morpholog1.02983326
88MP0001348_abnormal_lacrimal_gland1.02741673
89MP0001663_abnormal_digestive_system1.01356896
90MP0008789_abnormal_olfactory_epithelium1.01342615
91MP0003828_pulmonary_edema1.01114282
92MP0009840_abnormal_foam_cell0.99980229
93MP0003705_abnormal_hypodermis_morpholog0.98911379
94MP0002933_joint_inflammation0.97739488
95MP0000465_gastrointestinal_hemorrhage0.96747502
96MP0005381_digestive/alimentary_phenotyp0.94979530
97MP0009278_abnormal_bone_marrow0.94844157
98MP0003763_abnormal_thymus_physiology0.94691239
99MP0002102_abnormal_ear_morphology0.93115918
100MP0004808_abnormal_hematopoietic_stem0.92806822
101MP0009765_abnormal_xenobiotic_induced0.91185496
102MP0002009_preneoplasia0.91115648
103MP0003566_abnormal_cell_adhesion0.90054848
104MP0002998_abnormal_bone_remodeling0.89861087
105MP0000015_abnormal_ear_pigmentation0.87186511
106MP0001851_eye_inflammation0.85549628
107MP0003938_abnormal_ear_development0.84706790
108MP0002163_abnormal_gland_morphology0.84422246
109MP0005023_abnormal_wound_healing0.84131358
110MP0003172_abnormal_lysosome_physiology0.83794110
111MP0001216_abnormal_epidermal_layer0.83109841
112MP0005083_abnormal_biliary_tract0.83011028
113MP0001958_emphysema0.81733082
114MP0008875_abnormal_xenobiotic_pharmacok0.81548640
115MP0003941_abnormal_skin_development0.81475680
116MP0001666_abnormal_nutrient_absorption0.80039782
117MP0003011_delayed_dark_adaptation0.79531574
118MP0001765_abnormal_ion_homeostasis0.79456820
119MP0000569_abnormal_digit_pigmentation0.79167654
120MP0003091_abnormal_cell_migration0.76974381
121MP0005390_skeleton_phenotype0.74853633
122MP0005394_taste/olfaction_phenotype0.74172095
123MP0005499_abnormal_olfactory_system0.74172095
124MP0000026_abnormal_inner_ear0.74066040
125MP0003186_abnormal_redox_activity0.73757847
126MP0006054_spinal_hemorrhage0.72691190
127MP0008961_abnormal_basal_metabolism0.72403564
128MP0005220_abnormal_exocrine_pancreas0.72032180
129MP0000249_abnormal_blood_vessel0.70918545
130MP0009053_abnormal_anal_canal0.70878197
131MP0009763_increased_sensitivity_to0.70821255
132MP0005085_abnormal_gallbladder_physiolo0.70350161
133MP0004264_abnormal_extraembryonic_tissu0.70334298
134MP0000371_diluted_coat_color0.69982590
135MP0000470_abnormal_stomach_morphology0.68490076
136MP0005164_abnormal_response_to0.67579372
137MP0001485_abnormal_pinna_reflex0.63157126
138MP0003136_yellow_coat_color0.60789546
139MP0001286_abnormal_eye_development0.60315586
140MP0002092_abnormal_eye_morphology0.60292342
141MP0001324_abnormal_eye_pigmentation0.55249108

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.78358662
2Recurrent abscess formation (HP:0002722)4.58231734
3Recurrent bacterial skin infections (HP:0005406)4.39624761
4Vacuolated lymphocytes (HP:0001922)3.79569150
5Hypochromic microcytic anemia (HP:0004840)3.76726037
6Recurrent gram-negative bacterial infections (HP:0005420)3.59660393
7Abnormality of macrophages (HP:0004311)3.41067927
8Thrombocytosis (HP:0001894)3.34862698
9Elevated erythrocyte sedimentation rate (HP:0003565)3.32220373
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.29798647
11Recurrent fungal infections (HP:0002841)3.24859608
12Reticulocytopenia (HP:0001896)3.24430754
13Myositis (HP:0100614)3.21944514
14Keratoconjunctivitis sicca (HP:0001097)3.11414954
15Recurrent skin infections (HP:0001581)3.04379229
16Hypochromic anemia (HP:0001931)3.03396760
17Mediastinal lymphadenopathy (HP:0100721)3.02300780
18Keratoconjunctivitis (HP:0001096)2.96144204
19Colitis (HP:0002583)2.94756007
20Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94719071
21Autoimmune thrombocytopenia (HP:0001973)2.90582490
22Orchitis (HP:0100796)2.86789484
23Chronic otitis media (HP:0000389)2.81887097
24Interstitial pulmonary disease (HP:0006530)2.79846035
25Inflammation of the large intestine (HP:0002037)2.77401101
26Hematochezia (HP:0002573)2.76376883
27Recurrent viral infections (HP:0004429)2.75946062
28Periodontitis (HP:0000704)2.75652699
29Panhypogammaglobulinemia (HP:0003139)2.72708141
30Gastrointestinal inflammation (HP:0004386)2.72044341
31Abnormality of chloride homeostasis (HP:0011422)2.65234394
32Episodic fever (HP:0001954)2.64398546
33Vasculitis (HP:0002633)2.62688134
34Cellulitis (HP:0100658)2.61326295
35IgM deficiency (HP:0002850)2.59356012
36Gingivitis (HP:0000230)2.58882525
37Abnormal ciliary motility (HP:0012262)2.53684996
38Spontaneous hematomas (HP:0007420)2.48648202
39Recurrent cutaneous fungal infections (HP:0011370)2.46900943
40Chronic mucocutaneous candidiasis (HP:0002728)2.46900943
41Hydroxyprolinuria (HP:0003080)2.45477994
42Abnormality of proline metabolism (HP:0010907)2.45477994
43Meningitis (HP:0001287)2.44567026
44Abnormal rod and cone electroretinograms (HP:0008323)2.43881277
45Chest pain (HP:0100749)2.42866293
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.42649231
47Recurrent sinusitis (HP:0011108)2.42616587
48Myocardial infarction (HP:0001658)2.42309546
49Obstructive lung disease (HP:0006536)2.42150889
50Chronic obstructive pulmonary disease (HP:0006510)2.42150889
51Dysostosis multiplex (HP:0000943)2.40896412
52Pustule (HP:0200039)2.38949323
53Reduced antithrombin III activity (HP:0001976)2.38387054
54Hyperactive renin-angiotensin system (HP:0000841)2.37680075
55Chronic sinusitis (HP:0011109)2.36226276
56Retrobulbar optic neuritis (HP:0100654)2.35970386
57Optic neuritis (HP:0100653)2.35970386
58True hermaphroditism (HP:0010459)2.34291343
59Abnormal respiratory epithelium morphology (HP:0012253)2.34268945
60Abnormal respiratory motile cilium morphology (HP:0005938)2.34268945
61Increased IgE level (HP:0003212)2.34225167
62Abnormal respiratory motile cilium physiology (HP:0012261)2.34224461
63Increased IgM level (HP:0003496)2.32702366
64Urinary glycosaminoglycan excretion (HP:0003541)2.31107112
65Mucopolysacchariduria (HP:0008155)2.31107112
66Anorexia (HP:0002039)2.30528034
67Systemic lupus erythematosus (HP:0002725)2.30315140
68Pancreatic cysts (HP:0001737)2.25482531
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22071082
70Nasal polyposis (HP:0100582)2.20613200
71Abnormality of the nasal mucosa (HP:0000433)2.20406500
72Septo-optic dysplasia (HP:0100842)2.20103342
73Peritonitis (HP:0002586)2.19993506
74Generalized aminoaciduria (HP:0002909)2.19832185
75Pulmonary infiltrates (HP:0002113)2.17067896
76Absent/shortened dynein arms (HP:0200106)2.15548859
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.15548859
78Agammaglobulinemia (HP:0004432)2.12473597
79Gingival bleeding (HP:0000225)2.12266485
80Abnormality of polysaccharide metabolism (HP:0011012)2.11819535
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11819535
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11819535
83Metabolic alkalosis (HP:0200114)2.11779319
84T lymphocytopenia (HP:0005403)2.11335591
85Stomach cancer (HP:0012126)2.11325012
86Recurrent bronchitis (HP:0002837)2.11104720
87Osteomyelitis (HP:0002754)2.10605753
88Hypokalemic alkalosis (HP:0001949)2.10136945
89Pancreatic fibrosis (HP:0100732)2.08571246
90Keratitis (HP:0000491)2.07611059
91Arterial thrombosis (HP:0004420)2.07590011
92Basal ganglia calcification (HP:0002135)2.07548134
93Esophageal varix (HP:0002040)2.05198819
94Glomerulonephritis (HP:0000099)2.03767923
95Skin ulcer (HP:0200042)2.02666575
96Abnormality of T cell number (HP:0011839)2.02559833
97Sepsis (HP:0100806)2.01551495
98Abnormality of cells of the erythroid lineage (HP:0012130)2.01185982
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.00968754
100Cheilitis (HP:0100825)2.00807360
101Epistaxis (HP:0000421)2.00386502
102Urticaria (HP:0001025)1.98786462
103Vertebral compression fractures (HP:0002953)1.98723507
104Encephalitis (HP:0002383)1.98269035
105Abnormality of T cells (HP:0002843)1.96098280
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96076672
107Lymphopenia (HP:0001888)1.95882175
108Hemoptysis (HP:0002105)1.95561518
109Rib fusion (HP:0000902)1.93254883
110Abnormal number of erythroid precursors (HP:0012131)1.91635304
111Nephritis (HP:0000123)1.90187754
112Leukocytosis (HP:0001974)1.88030933
113Abnormality of T cell physiology (HP:0011840)1.87980583
114Abnormality of the pleura (HP:0002103)1.87853982
115Anhidrosis (HP:0000970)1.87634554
116Stomatitis (HP:0010280)1.86476048
117Polyuria (HP:0000103)1.86330168
118Metaphyseal cupping (HP:0003021)1.85764542
119Petechiae (HP:0000967)1.85732286
120Impaired platelet aggregation (HP:0003540)1.85035492
121Abnormal platelet function (HP:0011869)1.85035492
122Abnormality of renal excretion (HP:0011036)1.83603370
123Gangrene (HP:0100758)1.83559467
124Bronchiectasis (HP:0002110)1.82518441
125Abnormality of the intervertebral disk (HP:0005108)1.82426584
126Abnormality of magnesium homeostasis (HP:0004921)1.80971947
127Hypergammaglobulinemia (HP:0010702)1.80832007
128Gastrointestinal infarctions (HP:0005244)1.80520679
129Anomalous pulmonary venous return (HP:0010772)1.80277094
130Prolonged bleeding time (HP:0003010)1.80083089
131Recurrent otitis media (HP:0000403)1.79973694
132Eosinophilia (HP:0001880)1.79943683
133Thoracic kyphosis (HP:0002942)1.79550579
134Joint hemorrhage (HP:0005261)1.79455586
135Amyloidosis (HP:0011034)1.78617335
136Oligodactyly (HP:0012165)1.78198640
137Abnormality of purine metabolism (HP:0004352)1.77419626
138Abnormal urine output (HP:0012590)1.77065184
139Abnormal hemoglobin (HP:0011902)1.76936412
140Recurrent pneumonia (HP:0006532)1.75640283
141Alkalosis (HP:0001948)1.75532475
142Microcytic anemia (HP:0001935)1.74851071
143Oligodactyly (hands) (HP:0001180)1.74608012
144Abnormality of incisor morphology (HP:0011063)1.73785090
145Alveolar cell carcinoma (HP:0006519)1.72238478
146Parakeratosis (HP:0001036)1.71663014
147Recurrent lower respiratory tract infections (HP:0002783)1.70909982
148Anophthalmia (HP:0000528)1.70703974
149Partial duplication of thumb phalanx (HP:0009944)1.69256340
150Abnormality of the nasal septum (HP:0000419)1.67941603
151Abnormal biliary tract physiology (HP:0012439)1.67452586
152Bile duct proliferation (HP:0001408)1.67452586
153Arthropathy (HP:0003040)1.66538485
154Chronic hepatic failure (HP:0100626)1.65954138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.51525274
2TBK12.83678742
3TYK22.75369984
4IRAK42.67862396
5ERN12.62639156
6CDK192.62249315
7IRAK32.49704016
8IKBKB2.49047819
9MAP4K12.40168294
10BLK2.38405630
11TGFBR22.27136984
12TNK22.17674036
13STK102.10741195
14KIT2.01566522
15CHUK1.95638249
16IKBKE1.92926557
17PIM21.88664654
18FLT31.86655391
19LRRK21.80315867
20JAK31.77898006
21BTK1.73767730
22TAOK11.72776069
23FGR1.70759098
24EPHB21.67395793
25RIPK41.63559690
26TXK1.61061985
27MARK21.59851311
28CSF1R1.52699179
29MST41.52126613
30EPHA31.51296111
31RPS6KA41.50807489
32FGFR41.47135066
33MAP2K31.43283029
34JAK11.41030304
35PIM11.40251114
36MAP3K31.38252866
37MAP3K71.38050033
38EPHB11.37775193
39NLK1.34926931
40PRKD21.32790936
41TEC1.32654471
42PTK61.28138986
43CSK1.27599775
44TGFBR11.22628485
45NME21.21878850
46TAOK31.19875518
47GRK61.13133903
48TRIB31.11249465
49NEK91.10640132
50TLK11.08777684
51EIF2AK31.08446478
52MAP2K21.07422479
53IRAK11.05895108
54DYRK31.04466571
55MATK1.04328457
56WNK41.04170528
57ZAP701.03872771
58DYRK1B1.00720375
59MAP3K100.97681809
60MST1R0.95337564
61HCK0.90609953
62TESK10.90351145
63SYK0.89604298
64MAP3K130.89323369
65FGFR20.88203507
66MAPK150.85559199
67PAK40.83012254
68* STK110.81239456
69PRKCQ0.81127343
70LYN0.80393979
71OXSR10.79816006
72JAK20.79800434
73MAPKAPK20.77114764
74ACVR1B0.76968507
75MAP3K10.76457651
76EIF2AK20.73979202
77PKN20.72791368
78RIPK10.72369436
79PIK3CA0.70991778
80PRKCZ0.70634211
81PTK2B0.70059589
82MAPKAPK30.70009698
83ITK0.69200463
84TESK20.68542568
85LCK0.68453247
86MELK0.67169227
87FYN0.66470171
88SIK30.66032225
89WNK30.65065379
90MAP3K110.65051870
91MAPK70.64690083
92CDK120.64133777
93FES0.63927860
94KSR20.62664689
95KSR10.62296641
96ABL20.61670758
97ABL10.60502043
98DYRK20.58312248
99YES10.57021937
100ERBB20.56518166
101PASK0.55936398
102BCR0.55723710
103MAP2K40.55641884
104SIK20.55434504
105STK380.54294491
106PRKCD0.53506215
107PRKAA20.53050767
108EPHA20.52757812
109CDK60.52645009
110MAP3K80.52001229
111HIPK20.51582335
112FGFR30.51337760
113PRPF4B0.51150233
114TRPM70.50967790
115IRAK20.50965178
116BRD40.50009739
117ADRBK10.49727016
118MARK30.49302935
119CLK10.49294294
120KDR0.48990553
121NTRK20.45958696
122RPS6KC10.45907234
123RPS6KL10.45907234
124CDK90.45458125
125TTN0.43661908
126MAPK40.43493861
127SCYL20.42802505
128SIK10.42657683
129GSK3A0.41475346
130MAPK110.41251413
131TYRO30.39685077
132PRKG20.39049118
133STK240.38994340
134BCKDK0.36994653
135EEF2K0.36992550
136STK40.35734221
137PDK10.35700866
138RPS6KA60.35454282
139FRK0.34717728
140CAMK10.34407144
141CAMK40.34044048
142BRSK20.33631629
143MAP3K20.33056608

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.91986109
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.57537416
3Autoimmune thyroid disease_Homo sapiens_hsa053202.32706426
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10302643
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04430718
6Osteoclast differentiation_Homo sapiens_hsa043801.99509542
7Other glycan degradation_Homo sapiens_hsa005111.93344796
8Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90037429
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.89308828
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88884055
11B cell receptor signaling pathway_Homo sapiens_hsa046621.87456763
12Measles_Homo sapiens_hsa051621.84043906
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80843199
14Staphylococcus aureus infection_Homo sapiens_hsa051501.76509997
15Antigen processing and presentation_Homo sapiens_hsa046121.75190233
16Pertussis_Homo sapiens_hsa051331.69835651
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68586116
18TNF signaling pathway_Homo sapiens_hsa046681.65864435
19Ribosome_Homo sapiens_hsa030101.64872351
20Toxoplasmosis_Homo sapiens_hsa051451.60607595
21Herpes simplex infection_Homo sapiens_hsa051681.58745323
22Legionellosis_Homo sapiens_hsa051341.55416741
23Shigellosis_Homo sapiens_hsa051311.52187994
24Apoptosis_Homo sapiens_hsa042101.51738684
25Malaria_Homo sapiens_hsa051441.51700797
26Tuberculosis_Homo sapiens_hsa051521.50145904
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.50026190
28Type I diabetes mellitus_Homo sapiens_hsa049401.47849082
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.46985270
30Primary immunodeficiency_Homo sapiens_hsa053401.46153575
31Hematopoietic cell lineage_Homo sapiens_hsa046401.45257489
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41532613
33Influenza A_Homo sapiens_hsa051641.39770187
34Graft-versus-host disease_Homo sapiens_hsa053321.37339294
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30052989
36Caffeine metabolism_Homo sapiens_hsa002321.24457852
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22362194
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.22162497
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21589716
40Acute myeloid leukemia_Homo sapiens_hsa052211.19618360
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.18015530
42Small cell lung cancer_Homo sapiens_hsa052221.13200484
43Basal cell carcinoma_Homo sapiens_hsa052171.12487502
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12286430
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09440954
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09235601
47FoxO signaling pathway_Homo sapiens_hsa040681.08022478
48Allograft rejection_Homo sapiens_hsa053301.07271196
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06768068
50Salmonella infection_Homo sapiens_hsa051321.04842286
51Hepatitis B_Homo sapiens_hsa051611.03655630
52p53 signaling pathway_Homo sapiens_hsa041151.03574991
53Hepatitis C_Homo sapiens_hsa051601.02859068
54Folate biosynthesis_Homo sapiens_hsa007901.01515129
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.01096377
56Renin-angiotensin system_Homo sapiens_hsa046140.99966148
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99271561
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96621623
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96247122
60Histidine metabolism_Homo sapiens_hsa003400.95495984
61Chronic myeloid leukemia_Homo sapiens_hsa052200.95429867
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94964370
63Lysosome_Homo sapiens_hsa041420.92937242
64Asthma_Homo sapiens_hsa053100.92079228
65Glutathione metabolism_Homo sapiens_hsa004800.90304672
66Tryptophan metabolism_Homo sapiens_hsa003800.89516516
67Chemokine signaling pathway_Homo sapiens_hsa040620.89018505
68Vitamin digestion and absorption_Homo sapiens_hsa049770.87947869
69Linoleic acid metabolism_Homo sapiens_hsa005910.87160059
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83893338
71Hedgehog signaling pathway_Homo sapiens_hsa043400.82979945
72Rap1 signaling pathway_Homo sapiens_hsa040150.80140611
73Regulation of autophagy_Homo sapiens_hsa041400.79241310
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.76111068
75Non-small cell lung cancer_Homo sapiens_hsa052230.74413007
76Sulfur relay system_Homo sapiens_hsa041220.73656708
77Dorso-ventral axis formation_Homo sapiens_hsa043200.73407947
78Complement and coagulation cascades_Homo sapiens_hsa046100.73302147
79Axon guidance_Homo sapiens_hsa043600.72822407
80Selenocompound metabolism_Homo sapiens_hsa004500.71650526
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70704081
82African trypanosomiasis_Homo sapiens_hsa051430.70413970
83VEGF signaling pathway_Homo sapiens_hsa043700.69647743
84Notch signaling pathway_Homo sapiens_hsa043300.68931463
85Viral myocarditis_Homo sapiens_hsa054160.68666974
86Peroxisome_Homo sapiens_hsa041460.68541367
87Choline metabolism in cancer_Homo sapiens_hsa052310.68071137
88Endocytosis_Homo sapiens_hsa041440.67560895
89Colorectal cancer_Homo sapiens_hsa052100.67270051
90MAPK signaling pathway_Homo sapiens_hsa040100.67081512
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66921151
92Epstein-Barr virus infection_Homo sapiens_hsa051690.65854171
93Platelet activation_Homo sapiens_hsa046110.65127364
94Endometrial cancer_Homo sapiens_hsa052130.64938128
95Inositol phosphate metabolism_Homo sapiens_hsa005620.64694575
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63656875
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63622741
98Bladder cancer_Homo sapiens_hsa052190.63147358
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61724656
100Prolactin signaling pathway_Homo sapiens_hsa049170.61370802
101Phagosome_Homo sapiens_hsa041450.60866128
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.60835659
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59639226
104Pentose phosphate pathway_Homo sapiens_hsa000300.59566371
105Rheumatoid arthritis_Homo sapiens_hsa053230.59006424
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.57791101
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56715479
108Viral carcinogenesis_Homo sapiens_hsa052030.56441978
109Amoebiasis_Homo sapiens_hsa051460.56417027
110Starch and sucrose metabolism_Homo sapiens_hsa005000.56391166
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56027692
112Pancreatic cancer_Homo sapiens_hsa052120.55861274
113T cell receptor signaling pathway_Homo sapiens_hsa046600.54885508
114Ether lipid metabolism_Homo sapiens_hsa005650.54833743
115beta-Alanine metabolism_Homo sapiens_hsa004100.54551828
116Adherens junction_Homo sapiens_hsa045200.54461033
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54414441
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54279135
119Chemical carcinogenesis_Homo sapiens_hsa052040.53727912
120ABC transporters_Homo sapiens_hsa020100.53662919
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53152280
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52769463
123Renal cell carcinoma_Homo sapiens_hsa052110.52292606
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52229550
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.51998064
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.50167550
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.50057933
128HTLV-I infection_Homo sapiens_hsa051660.49784672
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.49745674
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49643403
131Pathways in cancer_Homo sapiens_hsa052000.48978879
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48919177
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48687367
134MicroRNAs in cancer_Homo sapiens_hsa052060.47872984
135Ras signaling pathway_Homo sapiens_hsa040140.47857766
136One carbon pool by folate_Homo sapiens_hsa006700.47367124
137Wnt signaling pathway_Homo sapiens_hsa043100.47137874
138Nitrogen metabolism_Homo sapiens_hsa009100.45861450
139Arachidonic acid metabolism_Homo sapiens_hsa005900.43170757
140Sulfur metabolism_Homo sapiens_hsa009200.42998901
141Thyroid cancer_Homo sapiens_hsa052160.39088770
142Insulin resistance_Homo sapiens_hsa049310.37676446

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