NTSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine biosynthetic process (GO:0042416)8.13044680
2dopamine transport (GO:0015872)7.31376549
3activation of Rac GTPase activity (GO:0032863)6.67527880
4neuron cell-cell adhesion (GO:0007158)6.64945499
5alkaloid metabolic process (GO:0009820)6.36574704
6glutamate secretion (GO:0014047)5.96359867
7synaptic vesicle exocytosis (GO:0016079)5.83941010
8catecholamine transport (GO:0051937)5.78247292
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57803883
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42403309
11regulation of glucose import in response to insulin stimulus (GO:2001273)5.41807246
12synaptic vesicle maturation (GO:0016188)5.40035705
13vocalization behavior (GO:0071625)5.33933694
14mating behavior (GO:0007617)5.17118708
15mesodermal cell differentiation (GO:0048333)5.05113285
16locomotory exploration behavior (GO:0035641)4.90078734
17prepulse inhibition (GO:0060134)4.79015234
18layer formation in cerebral cortex (GO:0021819)4.74482733
19catechol-containing compound biosynthetic process (GO:0009713)4.71818635
20catecholamine biosynthetic process (GO:0042423)4.71818635
21exploration behavior (GO:0035640)4.69770439
22response to insecticide (GO:0017085)4.69040528
23bone remodeling (GO:0046849)4.63017619
24hemidesmosome assembly (GO:0031581)4.62719683
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54101687
26mammary gland epithelial cell proliferation (GO:0033598)4.50150443
27neurotransmitter biosynthetic process (GO:0042136)4.49038749
28regulation of synaptic vesicle exocytosis (GO:2000300)4.48544039
29regulation of synapse structural plasticity (GO:0051823)4.47167816
30neurotransmitter secretion (GO:0007269)4.41531927
31regulation of catecholamine metabolic process (GO:0042069)4.39201920
32regulation of dopamine metabolic process (GO:0042053)4.39201920
33pyrimidine nucleobase catabolic process (GO:0006208)4.38845269
34synaptic transmission, dopaminergic (GO:0001963)4.24433574
35desmosome organization (GO:0002934)4.23667686
36semaphorin-plexin signaling pathway (GO:0071526)4.21695085
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12414335
38neuron recognition (GO:0008038)4.09889945
39branching involved in mammary gland duct morphogenesis (GO:0060444)4.05831612
40cerebellar Purkinje cell layer development (GO:0021680)4.05132896
41postsynaptic membrane organization (GO:0001941)4.04454730
42negative regulation of neurotransmitter transport (GO:0051589)4.03666239
43negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.02992633
44protein localization to synapse (GO:0035418)4.02801197
45regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01984476
46hypotonic response (GO:0006971)4.00459540
47regulation of neurotransmitter levels (GO:0001505)4.00145586
48Golgi transport vesicle coating (GO:0048200)3.98540664
49COPI coating of Golgi vesicle (GO:0048205)3.98540664
50regulation of glutamate receptor signaling pathway (GO:1900449)3.98154368
51neurotransmitter catabolic process (GO:0042135)3.97135354
52dopamine metabolic process (GO:0042417)3.95213413
53auditory behavior (GO:0031223)3.94935334
54proline transport (GO:0015824)3.94163209
55phenol-containing compound catabolic process (GO:0019336)3.90997154
56regulation of synaptic vesicle transport (GO:1902803)3.88683218
57neurotransmitter transport (GO:0006836)3.83380922
58proline biosynthetic process (GO:0006561)3.82341703
59gamma-aminobutyric acid transport (GO:0015812)3.79100944
60negative regulation of microtubule polymerization (GO:0031115)3.76463708
61synaptic vesicle docking involved in exocytosis (GO:0016081)3.75500282
62regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.74596769
63positive regulation of synapse maturation (GO:0090129)3.70881052
64synapse assembly (GO:0007416)3.65651812
65nucleobase catabolic process (GO:0046113)3.64928265
66synaptic vesicle transport (GO:0048489)3.62793026
67establishment of synaptic vesicle localization (GO:0097480)3.62793026
68heterochromatin organization (GO:0070828)3.62583101
69neurotransmitter metabolic process (GO:0042133)3.62228511
70behavioral response to cocaine (GO:0048148)3.61673527
71regulation of translational fidelity (GO:0006450)3.59706555
72regulation of neuronal synaptic plasticity (GO:0048168)3.58464746
73regulation of vesicle fusion (GO:0031338)3.57989826
74positive regulation of astrocyte differentiation (GO:0048711)3.55250559
75neuron-neuron synaptic transmission (GO:0007270)3.54110177
76establishment of integrated proviral latency (GO:0075713)3.52906871
77regulation of dopamine secretion (GO:0014059)3.51987037
78response to cocaine (GO:0042220)3.51903220
79axonal fasciculation (GO:0007413)3.50635447
80lung vasculature development (GO:0060426)3.46274900
81toxin metabolic process (GO:0009404)3.46034504
82ionotropic glutamate receptor signaling pathway (GO:0035235)3.45840908
83dendritic spine morphogenesis (GO:0060997)3.42466324
84receptor catabolic process (GO:0032801)3.42368235
85lung epithelium development (GO:0060428)3.39233031
86monoamine transport (GO:0015844)3.37543288
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36200093
88renal system development (GO:0072001)3.36183749
89innervation (GO:0060384)3.36009242
90dendrite morphogenesis (GO:0048813)3.35257365
91positive regulation of pseudopodium assembly (GO:0031274)3.34480502
92barbed-end actin filament capping (GO:0051016)3.30701550
93social behavior (GO:0035176)3.30238899
94intraspecies interaction between organisms (GO:0051703)3.30238899
95endothelial cell morphogenesis (GO:0001886)3.29427390
96synaptic vesicle endocytosis (GO:0048488)3.29047327
97response to auditory stimulus (GO:0010996)3.28185997
98presynaptic membrane assembly (GO:0097105)3.27781639
99cytoskeletal anchoring at plasma membrane (GO:0007016)3.27511152
100response to amphetamine (GO:0001975)3.26638171
101DNA unwinding involved in DNA replication (GO:0006268)3.25484662
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.24796426
103mitotic chromosome condensation (GO:0007076)3.24781843
104peptidyl-threonine dephosphorylation (GO:0035970)3.23372365
105positive regulation of neurotransmitter transport (GO:0051590)3.22856567
106planar cell polarity pathway involved in neural tube closure (GO:0090179)3.22196842
107chaperone mediated protein folding requiring cofactor (GO:0051085)3.21795830
108apoptotic process involved in morphogenesis (GO:0060561)3.20813328
109response to histamine (GO:0034776)3.20014451
110negative regulation of chondrocyte differentiation (GO:0032331)3.19828908
111regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.19024764
112regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.19024764
113glutamate receptor signaling pathway (GO:0007215)3.18603365
114establishment of vesicle localization (GO:0051650)3.15326851
115synaptic transmission, glutamatergic (GO:0035249)3.14518942
116central nervous system projection neuron axonogenesis (GO:0021952)3.13781892
117keratinocyte proliferation (GO:0043616)3.13469860
118diaphragm development (GO:0060539)3.11665721
119clathrin coat assembly (GO:0048268)3.11511129
120neurotransmitter-gated ion channel clustering (GO:0072578)3.11266150
121activation of protein kinase A activity (GO:0034199)3.10664344
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09138843
123formation of translation preinitiation complex (GO:0001731)3.07719179
124negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.07283043
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07121675
126positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.06480428
127negative regulation of viral release from host cell (GO:1902187)3.06251653
128epithelial cell-cell adhesion (GO:0090136)3.04062739
129regulation of neurotransmitter transport (GO:0051588)3.03229178
130positive regulation of synapse assembly (GO:0051965)3.03040879
131synapse organization (GO:0050808)3.02988295
132protein localization to microtubule (GO:0035372)3.02965699
133phenol-containing compound biosynthetic process (GO:0046189)3.02615216
134regulation of synapse maturation (GO:0090128)3.02415424
135cell migration in hindbrain (GO:0021535)3.02345475
136mechanosensory behavior (GO:0007638)3.02244971
137regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02128347
138regulation of mammary gland epithelial cell proliferation (GO:0033599)3.00812331
139protein localization to endosome (GO:0036010)3.00545816
140positive regulation of neurotransmitter secretion (GO:0001956)3.00471459
141regulation of postsynaptic membrane potential (GO:0060078)3.00175227
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99417715
143response to pheromone (GO:0019236)2.99297897
144long-term memory (GO:0007616)2.99222263
145glucose catabolic process (GO:0006007)2.98614407
146positive regulation of DNA-dependent DNA replication (GO:2000105)2.98209682
147G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97979564
148organelle transport along microtubule (GO:0072384)2.97899458
149regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.97536779
150cell-substrate junction assembly (GO:0007044)2.97332709
151regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.95125235
152negative regulation of cell size (GO:0045792)2.94634476
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92899361
154lung morphogenesis (GO:0060425)2.92303852
155respiratory tube development (GO:0030323)2.92232006
156cell volume homeostasis (GO:0006884)2.91750208
157positive regulation of protein localization to plasma membrane (GO:1903078)2.91293196
158snRNA metabolic process (GO:0016073)2.90051564
159cellular protein complex localization (GO:0034629)2.89820063
160regulation of pseudopodium assembly (GO:0031272)2.87973368
161regulation of translational termination (GO:0006449)2.86742543
162skin morphogenesis (GO:0043589)2.85985230
163positive regulation of Cdc42 GTPase activity (GO:0043089)2.85385171
164signal complex assembly (GO:0007172)2.84587026
165regulation of viral release from host cell (GO:1902186)2.83756975
166mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.82203105
167chondrocyte proliferation (GO:0035988)2.81963100
168developmental programmed cell death (GO:0010623)2.81267489
169myelin maintenance (GO:0043217)2.79141377
170establishment of viral latency (GO:0019043)2.76156802
171cellular senescence (GO:0090398)2.73818728
172trophoblast giant cell differentiation (GO:0060707)2.72935719
173regulation of cholesterol biosynthetic process (GO:0045540)2.67207890
174mitotic nuclear envelope reassembly (GO:0007084)2.66983853
175nuclear envelope reassembly (GO:0031468)2.66983853
176response to methylmercury (GO:0051597)2.63800735
177ncRNA 3-end processing (GO:0043628)2.63070046
178glial cell migration (GO:0008347)2.62417123
179snRNA processing (GO:0016180)2.60708931
180cell-substrate adherens junction assembly (GO:0007045)2.59403175
181focal adhesion assembly (GO:0048041)2.59403175
182pattern specification involved in kidney development (GO:0061004)2.58595792
183regulation of lamellipodium assembly (GO:0010591)2.58594828
184mesenchymal cell differentiation involved in kidney development (GO:0072161)2.56574715
185mesenchymal cell differentiation involved in renal system development (GO:2001012)2.56574715
186positive regulation of dendritic spine morphogenesis (GO:0061003)2.56506083
187neural tube development (GO:0021915)2.56074446
188positive regulation of osteoblast proliferation (GO:0033690)2.55972127
189thrombin receptor signaling pathway (GO:0070493)2.55300880
190collecting duct development (GO:0072044)2.53909410
191adherens junction assembly (GO:0034333)2.52094907
192retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51917053
193actin filament bundle assembly (GO:0051017)2.50908739
194actin filament bundle organization (GO:0061572)2.50908739
195protein retention in ER lumen (GO:0006621)2.50144684
196nuclear pore complex assembly (GO:0051292)2.49543252
197morphogenesis of an endothelium (GO:0003159)2.48680191
198endothelial tube morphogenesis (GO:0061154)2.48680191
199stress fiber assembly (GO:0043149)2.48338003
200maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48159938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.87974845
2EZH2_22144423_ChIP-Seq_EOC_Human5.85529831
3ZNF263_19887448_ChIP-Seq_K562_Human3.81636393
4GBX2_23144817_ChIP-Seq_PC3_Human3.56853777
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.25699533
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16282751
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05428208
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.97668959
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93304284
10E2F7_22180533_ChIP-Seq_HELA_Human2.92556697
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91218346
12REST_21632747_ChIP-Seq_MESCs_Mouse2.69428366
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.66007300
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54174707
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53604453
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53604453
17TAF15_26573619_Chip-Seq_HEK293_Human2.52782038
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.51742395
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.48906538
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47729121
21DROSHA_22980978_ChIP-Seq_HELA_Human2.47679333
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47318668
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44836797
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44736512
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43143736
26MYC_22102868_ChIP-Seq_BL_Human2.43127418
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42743492
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24699889
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.22787457
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21853282
31IGF1R_20145208_ChIP-Seq_DFB_Human2.21651578
32* LXR_22292898_ChIP-Seq_THP-1_Human2.20638055
33RACK7_27058665_Chip-Seq_MCF-7_Human2.20113951
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18761224
35EZH2_27294783_Chip-Seq_ESCs_Mouse2.16963681
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.15918404
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15715634
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.15296992
39CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14568948
40VDR_21846776_ChIP-Seq_THP-1_Human2.12463315
41RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12059899
42ZNF274_21170338_ChIP-Seq_K562_Hela2.09040882
43* ATF3_27146783_Chip-Seq_COLON_Human2.07390406
44RARB_27405468_Chip-Seq_BRAIN_Mouse2.06363032
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.05287019
46RNF2_27304074_Chip-Seq_ESCs_Mouse2.00110606
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98320540
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98081388
49AR_21572438_ChIP-Seq_LNCaP_Human1.97695369
50* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95072173
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89863641
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.89786000
53* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.88978104
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88575577
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86786612
56TCF7_22412390_ChIP-Seq_EML_Mouse1.84719695
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81271533
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.71251697
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.70512981
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70488887
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69112078
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66872692
63SMAD4_21799915_ChIP-Seq_A2780_Human1.64189831
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64070226
65TP53_22127205_ChIP-Seq_IMR90_Human1.61748587
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60274338
67KDM2B_26808549_Chip-Seq_K562_Human1.59481239
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59458928
69* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59453880
70* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59214624
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56465740
72DCP1A_22483619_ChIP-Seq_HELA_Human1.52537762
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.51173401
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50392814
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49355311
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.49246362
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48050440
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47335334
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44915993
80P300_19829295_ChIP-Seq_ESCs_Human1.43979742
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43470410
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43101595
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43074700
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43006629
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.42974619
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42405740
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41721705
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.40845472
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40295716
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40162802
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40113748
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39114686
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39029662
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38732916
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37907030
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37633057
97KDM2B_26808549_Chip-Seq_DND41_Human1.36190570
98AR_21909140_ChIP-Seq_LNCAP_Human1.35330079
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34918666
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34346522
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32310036
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.30518112
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29755878
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.28440277
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.28216186
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28070227
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28070227
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27142579
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26782152
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26700602
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26447439
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26353537
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25743588
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24863431
115UBF1/2_26484160_Chip-Seq_HMECs_Human1.24781237
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24178142
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.23689672
118AR_25329375_ChIP-Seq_VCAP_Human1.22440024
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22365903
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.21959394
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20977499
122SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20437715
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18986458
124FUS_26573619_Chip-Seq_HEK293_Human1.18901481
125POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18526221
126* P68_20966046_ChIP-Seq_HELA_Human1.18151090
127XRN2_22483619_ChIP-Seq_HELA_Human1.17726180
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16984158
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16839069
130TP53_16413492_ChIP-PET_HCT116_Human1.16663228
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.12860955
132NCOR1_26117541_ChIP-Seq_K562_Human1.12747632
133ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12714452
134MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12598441
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12568936
136* STAT3_23295773_ChIP-Seq_U87_Human1.11655208
137AR_19668381_ChIP-Seq_PC3_Human1.11359969
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10579661
139MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09777534
140HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09668888
141RNF2_27304074_Chip-Seq_NSC_Mouse1.09496420
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08575680
143TP53_18474530_ChIP-ChIP_U2OS_Human1.08501722
144* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08010896
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07737997
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07383613
147VDR_24763502_ChIP-Seq_THP-1_Human1.06613769
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06184347
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06073455
150CREB1_26743006_Chip-Seq_LNCaP_Human1.05372211
151BCAT_22108803_ChIP-Seq_LS180_Human1.05317985
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05224192
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05082095
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05017425
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03884597
156CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03739731
157* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03708529
158* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03676073
159JUN_21703547_ChIP-Seq_K562_Human1.03511832
160TCF4_23295773_ChIP-Seq_U87_Human1.02658498
161RARB_24833708_ChIP-Seq_LIVER_Mouse1.02265351
162ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02107838
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02093728
164POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02093728
165ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02006844
166KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00574502
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99494906
168RUNX2_22187159_ChIP-Seq_PCA_Human0.99048619
169TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99045931
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98654387
171PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98022186
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97044313
173TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96264588
174RUNX1_22412390_ChIP-Seq_EML_Mouse0.95798795
175SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95110730
176SMAD3_21741376_ChIP-Seq_ESCs_Human0.95060157
177VDR_22108803_ChIP-Seq_LS180_Human0.94932554
178ER_23166858_ChIP-Seq_MCF-7_Human0.94756389
179P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94749828
180RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94737336
181WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94385007
182TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94291313
183ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93797217
184TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93408371
185ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93061170
186BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91307840
187CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89700412
188RARA_24833708_ChIP-Seq_LIVER_Mouse0.88909875
189GABP_19822575_ChIP-Seq_HepG2_Human0.88739226
190CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88630103
191BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88472621
192ARNT_22903824_ChIP-Seq_MCF-7_Human0.88397169
193* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87216459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.46877523
2MP0004859_abnormal_synaptic_plasticity5.46316553
3* MP0003635_abnormal_synaptic_transmissio3.76151270
4MP0004185_abnormal_adipocyte_glucose3.71423504
5MP0005423_abnormal_somatic_nervous3.45822626
6MP0001529_abnormal_vocalization3.42045382
7* MP0001905_abnormal_dopamine_level3.36356624
8MP0002877_abnormal_melanocyte_morpholog3.30190837
9MP0005076_abnormal_cell_differentiation3.14304741
10MP0002063_abnormal_learning/memory/cond3.02597898
11MP0009745_abnormal_behavioral_response2.98380140
12MP0006276_abnormal_autonomic_nervous2.98229937
13MP0004270_analgesia2.94989080
14MP0009046_muscle_twitch2.86421434
15MP0002064_seizures2.83197196
16MP0000566_synostosis2.82401558
17MP0003705_abnormal_hypodermis_morpholog2.66997707
18MP0001968_abnormal_touch/_nociception2.59527995
19MP0002572_abnormal_emotion/affect_behav2.58969336
20MP0003453_abnormal_keratinocyte_physiol2.53151897
21MP0004924_abnormal_behavior2.47399926
22MP0005386_behavior/neurological_phenoty2.47399926
23MP0002822_catalepsy2.43479727
24MP0005501_abnormal_skin_physiology2.41444123
25MP0002734_abnormal_mechanical_nocicepti2.39438558
26MP0002139_abnormal_hepatobiliary_system2.34555706
27MP0005257_abnormal_intraocular_pressure2.25874693
28MP0001440_abnormal_grooming_behavior2.22653532
29MP0000778_abnormal_nervous_system2.22595965
30MP0002909_abnormal_adrenal_gland2.20508402
31MP0005451_abnormal_body_composition2.19185991
32MP0001849_ear_inflammation2.16962709
33MP0001501_abnormal_sleep_pattern2.15846874
34MP0002796_impaired_skin_barrier2.13571966
35MP0003122_maternal_imprinting2.07266829
36MP0002736_abnormal_nociception_after2.02698360
37MP0002060_abnormal_skin_morphology1.99393390
38MP0002184_abnormal_innervation1.98196594
39* MP0001486_abnormal_startle_reflex1.98165312
40* MP0002733_abnormal_thermal_nociception1.97673385
41MP0005666_abnormal_adipose_tissue1.95266872
42MP0000537_abnormal_urethra_morphology1.94122035
43MP0002557_abnormal_social/conspecific_i1.92879645
44MP0002735_abnormal_chemical_nociception1.92572914
45MP0002272_abnormal_nervous_system1.90154995
46MP0002089_abnormal_postnatal_growth/wei1.89532231
47MP0001188_hyperpigmentation1.84583846
48MP0002067_abnormal_sensory_capabilities1.83828280
49MP0000569_abnormal_digit_pigmentation1.79040001
50MP0003329_amyloid_beta_deposits1.75711451
51MP0009780_abnormal_chondrocyte_physiolo1.74942741
52MP0010030_abnormal_orbit_morphology1.74562887
53MP0004811_abnormal_neuron_physiology1.72350065
54MP0010352_gastrointestinal_tract_polyps1.71799651
55MP0000762_abnormal_tongue_morphology1.67826728
56MP0002249_abnormal_larynx_morphology1.67104263
57* MP0001970_abnormal_pain_threshold1.66758549
58MP0008438_abnormal_cutaneous_collagen1.65197329
59MP0008872_abnormal_physiological_respon1.64585536
60MP0005248_abnormal_Harderian_gland1.61690102
61MP0004272_abnormal_basement_membrane1.60666309
62MP0000955_abnormal_spinal_cord1.57888911
63MP0000467_abnormal_esophagus_morphology1.56271567
64MP0005670_abnormal_white_adipose1.56104009
65MP0000733_abnormal_muscle_development1.56044673
66MP0003123_paternal_imprinting1.54645155
67MP0005409_darkened_coat_color1.46213037
68MP0004858_abnormal_nervous_system1.40648670
69* MP0002066_abnormal_motor_capabilities/c1.38609104
70MP0004957_abnormal_blastocyst_morpholog1.38325648
71MP0000858_altered_metastatic_potential1.35476234
72MP0001216_abnormal_epidermal_layer1.35207179
73MP0002882_abnormal_neuron_morphology1.33539962
74MP0004197_abnormal_fetal_growth/weight/1.33434907
75MP0003566_abnormal_cell_adhesion1.33417474
76MP0003111_abnormal_nucleus_morphology1.33251505
77MP0004264_abnormal_extraembryonic_tissu1.33178186
78MP0000516_abnormal_urinary_system1.32249432
79MP0005367_renal/urinary_system_phenotyp1.32249432
80MP0004808_abnormal_hematopoietic_stem1.31094551
81MP0008961_abnormal_basal_metabolism1.30130260
82MP0001984_abnormal_olfaction1.30058363
83MP0010771_integument_phenotype1.29782278
84MP0010678_abnormal_skin_adnexa1.27945932
85MP0003091_abnormal_cell_migration1.26858688
86MP0005646_abnormal_pituitary_gland1.26153459
87MP0000613_abnormal_salivary_gland1.25971656
88MP0002098_abnormal_vibrissa_morphology1.24545822
89MP0005164_abnormal_response_to1.19418112
90MP0008569_lethality_at_weaning1.18205366
91MP0002837_dystrophic_cardiac_calcinosis1.17955647
92MP0000631_abnormal_neuroendocrine_gland1.13795446
93MP0002152_abnormal_brain_morphology1.13401693
94MP0003943_abnormal_hepatobiliary_system1.12279993
95MP0000490_abnormal_crypts_of1.12256571
96MP0002090_abnormal_vision1.11562632
97MP0002896_abnormal_bone_mineralization1.10922467
98MP0005375_adipose_tissue_phenotype1.09020338
99MP0003879_abnormal_hair_cell1.08931527
100MP0008260_abnormal_autophagy1.06712472
101MP0001730_embryonic_growth_arrest1.06274966
102MP0009697_abnormal_copulation1.05967323
103MP0002086_abnormal_extraembryonic_tissu1.05470756
104MP0000579_abnormal_nail_morphology1.04620550
105MP0003631_nervous_system_phenotype1.03485670
106MP0000751_myopathy1.03275060
107MP0003632_abnormal_nervous_system1.03113922
108MP0000350_abnormal_cell_proliferation1.01922946
109MP0003115_abnormal_respiratory_system1.01818246
110MP0010094_abnormal_chromosome_stability1.01141971
111MP0004142_abnormal_muscle_tone1.00359527
112MP0002080_prenatal_lethality0.99399654
113MP0000432_abnormal_head_morphology0.98630335
114* MP0005535_abnormal_body_temperature0.98502143
115MP0001502_abnormal_circadian_rhythm0.98024184
116MP0005621_abnormal_cell_physiology0.95504166
117MP0005508_abnormal_skeleton_morphology0.94210018
118MP0003191_abnormal_cellular_cholesterol0.94133125
119MP0003633_abnormal_nervous_system0.93864457
120MP0004233_abnormal_muscle_weight0.93286026
121MP0004947_skin_inflammation0.92457549
122MP0004885_abnormal_endolymph0.92226929
123MP0001348_abnormal_lacrimal_gland0.92196617
124MP0004883_abnormal_blood_vessel0.91817908
125MP0000428_abnormal_craniofacial_morphol0.91654704
126MP0005645_abnormal_hypothalamus_physiol0.91473682
127MP0005187_abnormal_penis_morphology0.90865593
128MP0001177_atelectasis0.90834960
129* MP0002970_abnormal_white_adipose0.90526605
130MP0000534_abnormal_ureter_morphology0.89745188
131MP0009053_abnormal_anal_canal0.89492051
132MP0005023_abnormal_wound_healing0.89338786
133MP0003693_abnormal_embryo_hatching0.89311110
134MP0000639_abnormal_adrenal_gland0.88207133
135MP0003984_embryonic_growth_retardation0.87448373
136MP0004742_abnormal_vestibular_system0.87369020
137MP0003077_abnormal_cell_cycle0.87108540
138MP0003315_abnormal_perineum_morphology0.85772059
139MP0003385_abnormal_body_wall0.85574077
140MP0009931_abnormal_skin_appearance0.84056375
141MP0002932_abnormal_joint_morphology0.83722953
142MP0000759_abnormal_skeletal_muscle0.83137786
143MP0008007_abnormal_cellular_replicative0.82842714
144MP0005380_embryogenesis_phenotype0.81943237
145MP0001672_abnormal_embryogenesis/_devel0.81943237
146MP0002751_abnormal_autonomic_nervous0.80604071
147* MP0001664_abnormal_digestion0.80317848
148MP0001727_abnormal_embryo_implantation0.80016641
149* MP0002069_abnormal_eating/drinking_beha0.79831594
150MP0008874_decreased_physiological_sensi0.78311252
151MP0002085_abnormal_embryonic_tissue0.78075107
152MP0005394_taste/olfaction_phenotype0.77401136
153MP0005499_abnormal_olfactory_system0.77401136
154MP0002229_neurodegeneration0.77247646
155MP0003045_fibrosis0.77152008
156MP0001697_abnormal_embryo_size0.76530540
157MP0003656_abnormal_erythrocyte_physiolo0.75864586
158MP0002088_abnormal_embryonic_growth/wei0.75489535
159MP0000604_amyloidosis0.75293438
160MP0003634_abnormal_glial_cell0.75085548
161MP0000747_muscle_weakness0.73423555
162MP0000538_abnormal_urinary_bladder0.73047802
163MP0003868_abnormal_feces_composition0.72784728
164MP0000358_abnormal_cell_content/0.71298055
165MP0008932_abnormal_embryonic_tissue0.71195312
166MP0003942_abnormal_urinary_system0.71159841
167MP0002332_abnormal_exercise_endurance0.70891964
168MP0005384_cellular_phenotype0.70755696
169MP0005623_abnormal_meninges_morphology0.70109075
170MP0004134_abnormal_chest_morphology0.68755283
171MP0002752_abnormal_somatic_nervous0.68595995
172MP0002111_abnormal_tail_morphology0.67546855
173MP0003787_abnormal_imprinting0.66967548
174MP0000678_abnormal_parathyroid_gland0.66947127
175MP0002084_abnormal_developmental_patter0.66946200
176MP0004085_abnormal_heartbeat0.66640844
177MP0000377_abnormal_hair_follicle0.66576632
178MP0003861_abnormal_nervous_system0.66195208
179MP0001943_abnormal_respiration0.65552472
180MP0001299_abnormal_eye_distance/0.63769867
181MP0000013_abnormal_adipose_tissue0.61268971
182MP0002876_abnormal_thyroid_physiology0.61144010
183MP0005551_abnormal_eye_electrophysiolog0.59827601
184MP0001963_abnormal_hearing_physiology0.59489796
185MP0003283_abnormal_digestive_organ0.58488031
186MP0010234_abnormal_vibrissa_follicle0.56979302
187MP0010770_preweaning_lethality0.55533815
188MP0002082_postnatal_lethality0.55533815
189MP0004145_abnormal_muscle_electrophysio0.54455642
190MP0010769_abnormal_survival0.53482507
191MP0000681_abnormal_thyroid_gland0.52653784

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)6.10131784
2Insomnia (HP:0100785)5.67437493
3Pheochromocytoma (HP:0002666)4.96372959
4Focal motor seizures (HP:0011153)4.79954488
5Myokymia (HP:0002411)4.76410395
6Hyperacusis (HP:0010780)4.68500162
7Upper limb amyotrophy (HP:0009129)4.57863629
8Distal upper limb amyotrophy (HP:0007149)4.57863629
9Neuroendocrine neoplasm (HP:0100634)4.41620294
10Focal seizures (HP:0007359)4.41187128
11Diaphragmatic weakness (HP:0009113)4.35494243
12Cerebral inclusion bodies (HP:0100314)4.17856552
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.04376133
14Mutism (HP:0002300)4.00753793
15Progressive cerebellar ataxia (HP:0002073)3.96871121
16Hand muscle atrophy (HP:0009130)3.91708653
17Epileptic encephalopathy (HP:0200134)3.80739113
18Distal lower limb amyotrophy (HP:0008944)3.79633365
19Failure to thrive in infancy (HP:0001531)3.65568336
20Supranuclear gaze palsy (HP:0000605)3.65452182
21Fragile skin (HP:0001030)3.59472572
22Upper limb muscle weakness (HP:0003484)3.55717858
23Morphological abnormality of the pyramidal tract (HP:0002062)3.41768727
24Papilledema (HP:0001085)3.40356138
25Neurofibrillary tangles (HP:0002185)3.37850350
26Increased connective tissue (HP:0009025)3.33339748
27Akinesia (HP:0002304)3.27617215
28Facial shape deformation (HP:0011334)3.27457788
29Potter facies (HP:0002009)3.27457788
30Ankle clonus (HP:0011448)3.20087129
31Achilles tendon contracture (HP:0001771)3.18405983
32Hypoventilation (HP:0002791)3.17904915
33Selective tooth agenesis (HP:0001592)3.15419328
34Aplasia cutis congenita (HP:0001057)3.13262728
35Generalized tonic-clonic seizures (HP:0002069)3.12943015
36Progressive inability to walk (HP:0002505)3.12261732
37Elfin facies (HP:0004428)3.08918782
38Abnormality of the corticospinal tract (HP:0002492)3.06978903
39Broad-based gait (HP:0002136)3.03428942
40Polyphagia (HP:0002591)2.99988354
41Mildly elevated creatine phosphokinase (HP:0008180)2.98437170
42Amyotrophic lateral sclerosis (HP:0007354)2.97389835
43Bradykinesia (HP:0002067)2.96105534
44Diminished movement (HP:0002374)2.96091343
45Hemorrhage of the eye (HP:0011885)2.94356930
46J-shaped sella turcica (HP:0002680)2.87994247
47Neoplasm of the peripheral nervous system (HP:0100007)2.86310429
48Rigidity (HP:0002063)2.85822496
49Premature skin wrinkling (HP:0100678)2.85816959
50Depression (HP:0000716)2.85597480
51Urethral obstruction (HP:0000796)2.85416986
52Ankyloglossia (HP:0010296)2.85370528
53Abnormality of the distal phalanges of the toes (HP:0010182)2.80716324
54Torticollis (HP:0000473)2.80640785
55Distal lower limb muscle weakness (HP:0009053)2.79866251
56Muscular hypotonia of the trunk (HP:0008936)2.79781416
57Ulnar bowing (HP:0003031)2.78576673
58Abnormality of binocular vision (HP:0011514)2.76827223
59Diplopia (HP:0000651)2.76827223
60Abnormality of the Achilles tendon (HP:0005109)2.75964413
61Anxiety (HP:0000739)2.75922502
62Hypothermia (HP:0002045)2.75754453
63Short nail (HP:0001799)2.71934274
64Drooling (HP:0002307)2.69051277
65Excessive salivation (HP:0003781)2.69051277
66Pili torti (HP:0003777)2.67795192
67Cerebral hemorrhage (HP:0001342)2.67021823
68Absence seizures (HP:0002121)2.65636926
69Hypokinesia (HP:0002375)2.64738464
70Truncal ataxia (HP:0002078)2.62908917
71Abnormal eating behavior (HP:0100738)2.61283750
72Proximal placement of thumb (HP:0009623)2.59319555
73Deviation of the thumb (HP:0009603)2.59068701
74Microglossia (HP:0000171)2.59035247
75Dyskinesia (HP:0100660)2.58328572
76Ureteral stenosis (HP:0000071)2.56298043
77Broad face (HP:0000283)2.55762193
78Fragile nails (HP:0001808)2.54642621
79Dialeptic seizures (HP:0011146)2.54032751
80Agitation (HP:0000713)2.53200621
81Poor eye contact (HP:0000817)2.53058958
82Difficulty climbing stairs (HP:0003551)2.52833199
83Abnormal pupillary function (HP:0007686)2.52135942
84Delayed gross motor development (HP:0002194)2.51713244
85Focal dystonia (HP:0004373)2.51418386
86Abnormality of oral frenula (HP:0000190)2.51379699
87Overriding aorta (HP:0002623)2.50213290
88Fetal akinesia sequence (HP:0001989)2.49082453
89Craniofacial dystonia (HP:0012179)2.48490191
90Lower limb amyotrophy (HP:0007210)2.47927876
91Premature rupture of membranes (HP:0001788)2.47696878
92Milia (HP:0001056)2.47266288
93Insidious onset (HP:0003587)2.45510281
94Termporal pattern (HP:0011008)2.45510281
95Progressive sensorineural hearing impairment (HP:0000408)2.44863409
96Micronodular cirrhosis (HP:0001413)2.44494581
97Hyperventilation (HP:0002883)2.42656352
98Progressive hearing impairment (HP:0001730)2.41583470
99Trismus (HP:0000211)2.38151304
100Urinary urgency (HP:0000012)2.37624169
101Urinary bladder sphincter dysfunction (HP:0002839)2.36080991
102Epileptiform EEG discharges (HP:0011182)2.35742837
103Spinal rigidity (HP:0003306)2.35490605
104Long palpebral fissure (HP:0000637)2.35196906
105Renal duplication (HP:0000075)2.35084514
106EEG with generalized epileptiform discharges (HP:0011198)2.34934198
107Tongue fasciculations (HP:0001308)2.33080093
108Hypercortisolism (HP:0001578)2.32828722
109Impaired vibration sensation in the lower limbs (HP:0002166)2.31274948
110Poikiloderma (HP:0001029)2.30732595
111Easy fatigability (HP:0003388)2.30210473
112Spastic gait (HP:0002064)2.29887840
113Inability to walk (HP:0002540)2.29846345
114Ureteral obstruction (HP:0006000)2.27993157
115Gastroesophageal reflux (HP:0002020)2.26581232
116Gaze-evoked nystagmus (HP:0000640)2.26545353
117Ridged nail (HP:0001807)2.25832337
118Hypsarrhythmia (HP:0002521)2.25756511
119Action tremor (HP:0002345)2.25143737
120Insulin resistance (HP:0000855)2.24652224
121Amblyopia (HP:0000646)2.24341121
122Impaired social interactions (HP:0000735)2.22826389
123Abnormal social behavior (HP:0012433)2.22826389
124Genetic anticipation (HP:0003743)2.21021958
125Atonic seizures (HP:0010819)2.20788715
126Pterygium (HP:0001059)2.18842580
127Focal segmental glomerulosclerosis (HP:0000097)2.18375066
128Increased nuchal translucency (HP:0010880)2.18174845
129Reduced subcutaneous adipose tissue (HP:0003758)2.15407968
130Vertebral arch anomaly (HP:0008438)2.14753822
131Cerebral aneurysm (HP:0004944)2.14618727
132Inappropriate behavior (HP:0000719)2.14532650
133Delusions (HP:0000746)2.14472626
134Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13536062
135Acanthosis nigricans (HP:0000956)2.11477783
136Postural tremor (HP:0002174)2.11474018
137Subacute progressive viral hepatitis (HP:0006572)2.11024750
138Generalized amyotrophy (HP:0003700)2.10145642
139Febrile seizures (HP:0002373)2.08618129
140Obstructive sleep apnea (HP:0002870)2.06862752
141Postural instability (HP:0002172)2.06013711
142Arnold-Chiari malformation (HP:0002308)2.04906234
143Abnormality of the parathyroid morphology (HP:0011766)2.04376559
144Patellar dislocation (HP:0002999)2.02561192
145Abnormality of calcium-phosphate metabolism (HP:0100530)2.02434932
146Sensory axonal neuropathy (HP:0003390)2.02273750
147Hemiparesis (HP:0001269)2.02213824
148Lower limb muscle weakness (HP:0007340)2.01652522
149Growth hormone excess (HP:0000845)2.00591291
150Limb dystonia (HP:0002451)11.0344578
151Muscle fibrillation (HP:0010546)1.99533223
152Gait ataxia (HP:0002066)1.99399105
153Dysmetria (HP:0001310)1.99341763
154Polar cataract (HP:0010696)1.99279244
155Elbow flexion contracture (HP:0002987)1.98892414
156Abnormality of the gastric mucosa (HP:0004295)1.95449819
157Abnormality of ocular smooth pursuit (HP:0000617)1.95349843
158Rough bone trabeculation (HP:0100670)1.94538885
159Apathy (HP:0000741)1.92066415
160Rapidly progressive (HP:0003678)1.90585615
161Generalized myoclonic seizures (HP:0002123)1.88612901
162Renovascular hypertension (HP:0100817)1.88555618
163Progressive external ophthalmoplegia (HP:0000590)1.88168467
164Aplasia involving bones of the extremities (HP:0009825)1.86970487
165Aplasia involving bones of the upper limbs (HP:0009823)1.86970487
166Aplasia of the phalanges of the hand (HP:0009802)1.86970487
167Distal sensory impairment (HP:0002936)1.85824732
168Sleep apnea (HP:0010535)1.83802338
169Limb hypertonia (HP:0002509)1.83155897
170Entropion (HP:0000621)1.83138658
171Megalencephaly (HP:0001355)1.82304705
172Gait imbalance (HP:0002141)1.81892061
173Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81521831
174Degeneration of the lateral corticospinal tracts (HP:0002314)1.81521831
175Absent speech (HP:0001344)1.81180556
176Pathologic fracture (HP:0002756)1.81113126
177Incomplete penetrance (HP:0003829)1.80846237
178Small epiphyses (HP:0010585)1.80549188
179Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80505713
180Stridor (HP:0010307)1.79490983
181Down-sloping shoulders (HP:0200021)1.76910861
182Abnormality of the sella turcica (HP:0002679)1.76699326
183Decreased motor nerve conduction velocity (HP:0003431)1.70669202
184Pointed chin (HP:0000307)1.70425334
185Atrophic scars (HP:0001075)1.68631424
186Periodontitis (HP:0000704)1.68573029
187Abnormality of the distal phalanx of the thumb (HP:0009617)1.68017479
188Glucose intolerance (HP:0000833)1.67262205
189Abnormality of the phalanges of the hallux (HP:0010057)1.67214096
190Bladder diverticulum (HP:0000015)1.67033930
191Flat acetabular roof (HP:0003180)1.66620845
192Curly hair (HP:0002212)1.66439876
193Flat cornea (HP:0007720)1.66245324
194Nuclear cataract (HP:0100018)1.64637899
195Shallow orbits (HP:0000586)1.64243513
196Plagiocephaly (HP:0001357)1.62781674
197Bowed forearm bones (HP:0003956)1.61391962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.21937483
2MARK15.66877580
3SIK14.36954707
4MAP3K94.06293405
5NME23.95596864
6IRAK33.54314728
7MAP3K123.12015605
8MAPKAPK52.94333700
9MET2.92787312
10MAP3K42.81963184
11MINK12.71773652
12TRIB32.58555256
13NTRK32.51450706
14PNCK2.41420021
15MAP2K72.41117879
16CSNK1G22.33202517
17MST42.29032963
18LATS22.22790076
19PAK42.20770767
20CSNK1G32.20603326
21PLK22.09171150
22EPHA42.07321620
23MAP2K42.02300310
24GRK52.00875489
25NTRK21.98141537
26PHKG21.80942140
27PHKG11.80942140
28CASK1.70857896
29MAPK131.69067056
30NTRK11.59985193
31ICK1.58705717
32PAK61.56186085
33CSNK1G11.53828419
34KSR21.52854550
35DAPK21.50686762
36CDK51.50198464
37SIK21.48809177
38EPHB11.43762204
39ERBB41.42859587
40RET1.41790885
41KSR11.40247380
42SMG11.37311813
43CDK151.36672153
44CDK181.35934592
45ARAF1.29484516
46CDK141.28459807
47CDK11A1.22698773
48EEF2K1.22577543
49DYRK21.19558860
50BUB11.17726061
51CAMK2A1.14414584
52PRKCG1.09806911
53IRAK21.08406926
54GRK61.05923253
55DAPK11.04755389
56BMX1.04181348
57TESK21.01767356
58CDK121.00845423
59ERN10.99806059
60CAMK2B0.97557727
61ERBB30.96875582
62SCYL20.95992872
63MAP3K100.95772937
64DYRK1A0.94613562
65CAMKK10.93808611
66STK100.93434404
67LATS10.91028193
68UHMK10.91010931
69FGR0.90482823
70CDK190.88134814
71ADRBK20.88083827
72PTK60.87821498
73RIPK10.86078240
74CDK80.82229868
75PAK30.81306216
76PRKD20.78455959
77IRAK40.77729830
78PRKCI0.77061355
79STK390.73983155
80PBK0.71478432
81WNK40.71399652
82TAOK20.69215807
83RIPK40.69071221
84FES0.68088262
85TNIK0.67939661
86PRKG20.67721018
87PTK2B0.67257743
88CAMK2D0.65541022
89PDGFRA0.64935036
90MAP2K30.63909203
91CAMK1G0.63734639
92STK110.63360017
93MTOR0.62911022
94TYRO30.62506533
95MARK20.61068351
96PKN10.58514430
97PRKCZ0.58248281
98PTK20.55999491
99MAP3K130.55946443
100MAP3K60.55190338
101EIF2AK10.52961129
102NEK20.52464012
103RPS6KA40.52353918
104PRKD30.52258584
105CSF1R0.52110252
106LMTK20.51652478
107CAMK2G0.51321248
108NME10.51312221
109MAP3K20.51158215
110ADRBK10.51085557
111CAMK1D0.51072623
112MAPK120.50940708
113FYN0.49992473
114MAP3K110.48274776
115MAP2K60.47083724
116TTN0.46436348
117TSSK60.45159488
118ALK0.44836655
119MAP3K80.44352537
120CCNB10.44231140
121RAF10.43962056
122STK380.43928627
123TESK10.43853440
124OXSR10.43385319
125PRPF4B0.43354820
126SGK4940.43272341
127SGK2230.43272341
128CSNK1A1L0.42922175
129RPS6KA20.42640743
130LIMK10.42037344
131PRKCH0.41617129
132LRRK20.40414329
133CDK70.38726780
134TAOK10.38288685
135SGK10.37691194
136PRKCE0.35852745
137CDK90.34513695
138PLK30.34026867
139CSNK1D0.33303497
140AKT20.33081706
141CAMK10.31509341
142PDPK10.31255626
143MOS0.30891239
144RPS6KA30.30880333
145PKN20.30468697
146PIM20.30447456
147WNK30.29171521
148EPHB20.28841369
149FGFR10.28284463
150ROCK20.28197786
151ABL20.27541289
152SIK30.26841766
153CHUK0.26208901
154MST1R0.26090016
155EIF2AK20.25923487
156PDK10.25904639
157MAP3K30.25347228
158FLT30.23655829
159RPS6KB20.22881883
160CHEK20.21965171
161DDR20.20969657
162WNK10.20732380
163MELK0.20025602
164DYRK1B0.18586169
165BRSK10.18311344
166BRD40.18156424
167CSK0.14256661
168CHEK10.13926510
169ILK0.13630258
170MAP3K140.12105616
171MAPKAPK20.12016569
172MAP3K10.11768726
173AURKB0.11600398
174IRAK10.11528617
175PAK10.11075643

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.23221276
2Nicotine addiction_Homo sapiens_hsa050333.50556765
3Cocaine addiction_Homo sapiens_hsa050303.50027835
4Amphetamine addiction_Homo sapiens_hsa050313.16866111
5Dopaminergic synapse_Homo sapiens_hsa047282.85921245
6GABAergic synapse_Homo sapiens_hsa047272.38768409
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34849406
8Circadian entrainment_Homo sapiens_hsa047132.31926369
9Fatty acid biosynthesis_Homo sapiens_hsa000612.29669756
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28519392
11Long-term potentiation_Homo sapiens_hsa047202.28382190
12Collecting duct acid secretion_Homo sapiens_hsa049662.26163854
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.13748272
14Cholinergic synapse_Homo sapiens_hsa047252.11214071
15Glutamatergic synapse_Homo sapiens_hsa047242.09507690
16Serotonergic synapse_Homo sapiens_hsa047262.07373700
17Morphine addiction_Homo sapiens_hsa050322.04007169
18Olfactory transduction_Homo sapiens_hsa047402.00537977
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97521998
20Parkinsons disease_Homo sapiens_hsa050121.94054297
21Chronic myeloid leukemia_Homo sapiens_hsa052201.91713627
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83444241
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79230689
24Basal cell carcinoma_Homo sapiens_hsa052171.78476239
25Long-term depression_Homo sapiens_hsa047301.72092302
26Salivary secretion_Homo sapiens_hsa049701.70990867
27Oxidative phosphorylation_Homo sapiens_hsa001901.66436707
28Notch signaling pathway_Homo sapiens_hsa043301.66365735
29Insulin secretion_Homo sapiens_hsa049111.66362897
30Vibrio cholerae infection_Homo sapiens_hsa051101.63525669
31Renin secretion_Homo sapiens_hsa049241.58063743
32Bladder cancer_Homo sapiens_hsa052191.57667709
33Proteoglycans in cancer_Homo sapiens_hsa052051.54751156
34Gap junction_Homo sapiens_hsa045401.52494216
35Gastric acid secretion_Homo sapiens_hsa049711.49708177
36Focal adhesion_Homo sapiens_hsa045101.49672914
37DNA replication_Homo sapiens_hsa030301.48508921
38Adherens junction_Homo sapiens_hsa045201.47195154
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46973167
40Base excision repair_Homo sapiens_hsa034101.43926825
41ECM-receptor interaction_Homo sapiens_hsa045121.43766343
42Hippo signaling pathway_Homo sapiens_hsa043901.40703039
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.39033232
44Shigellosis_Homo sapiens_hsa051311.37885115
45Axon guidance_Homo sapiens_hsa043601.37827059
46Taste transduction_Homo sapiens_hsa047421.36689785
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35516781
48Alzheimers disease_Homo sapiens_hsa050101.28735126
49GnRH signaling pathway_Homo sapiens_hsa049121.27491674
50Pancreatic cancer_Homo sapiens_hsa052121.26519067
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25447076
52Oxytocin signaling pathway_Homo sapiens_hsa049211.23918885
53Estrogen signaling pathway_Homo sapiens_hsa049151.21685948
54Non-homologous end-joining_Homo sapiens_hsa034501.20670243
55MicroRNAs in cancer_Homo sapiens_hsa052061.20492134
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20443688
57Pentose phosphate pathway_Homo sapiens_hsa000301.20166941
58Small cell lung cancer_Homo sapiens_hsa052221.19619471
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18376335
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16699841
61* Calcium signaling pathway_Homo sapiens_hsa040201.16293145
62Non-small cell lung cancer_Homo sapiens_hsa052231.15973751
63Cell cycle_Homo sapiens_hsa041101.14903504
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13463898
65Hedgehog signaling pathway_Homo sapiens_hsa043401.09224583
66Cardiac muscle contraction_Homo sapiens_hsa042601.08701551
67Acute myeloid leukemia_Homo sapiens_hsa052211.08205161
68Biosynthesis of amino acids_Homo sapiens_hsa012301.07489174
69Insulin resistance_Homo sapiens_hsa049311.07483974
70Alcoholism_Homo sapiens_hsa050341.06863729
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05194116
72mRNA surveillance pathway_Homo sapiens_hsa030151.03152668
73Melanogenesis_Homo sapiens_hsa049161.02742261
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02701279
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99181765
76RNA transport_Homo sapiens_hsa030130.99123147
77AMPK signaling pathway_Homo sapiens_hsa041520.98936676
78* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98913046
79Other glycan degradation_Homo sapiens_hsa005110.96734549
80Nucleotide excision repair_Homo sapiens_hsa034200.96584433
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.94420331
82Sulfur relay system_Homo sapiens_hsa041220.94380617
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91026448
84ErbB signaling pathway_Homo sapiens_hsa040120.90394646
85Apoptosis_Homo sapiens_hsa042100.90339414
86Fructose and mannose metabolism_Homo sapiens_hsa000510.90101160
87Salmonella infection_Homo sapiens_hsa051320.89886875
88Type II diabetes mellitus_Homo sapiens_hsa049300.89329589
89Glioma_Homo sapiens_hsa052140.87670245
90Pyrimidine metabolism_Homo sapiens_hsa002400.85764773
91Spliceosome_Homo sapiens_hsa030400.84408922
92Huntingtons disease_Homo sapiens_hsa050160.82244092
93Pathways in cancer_Homo sapiens_hsa052000.82056177
94cAMP signaling pathway_Homo sapiens_hsa040240.81872404
95N-Glycan biosynthesis_Homo sapiens_hsa005100.81454183
96Tyrosine metabolism_Homo sapiens_hsa003500.79506759
97Dorso-ventral axis formation_Homo sapiens_hsa043200.78639539
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78543517
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77467704
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77174021
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76311676
102Tight junction_Homo sapiens_hsa045300.75046673
103Inositol phosphate metabolism_Homo sapiens_hsa005620.74927222
104Oocyte meiosis_Homo sapiens_hsa041140.74233859
105Melanoma_Homo sapiens_hsa052180.73692935
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73527990
107p53 signaling pathway_Homo sapiens_hsa041150.71154095
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69740619
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67826708
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66816636
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66430777
112Prostate cancer_Homo sapiens_hsa052150.66056896
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.65457295
114Phenylalanine metabolism_Homo sapiens_hsa003600.64209133
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63813722
116Hepatitis C_Homo sapiens_hsa051600.63635453
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62937197
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62814349
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62635040
120Lysine degradation_Homo sapiens_hsa003100.62543264
121Thyroid hormone synthesis_Homo sapiens_hsa049180.62361489
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61816199
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60155548
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58838604
125African trypanosomiasis_Homo sapiens_hsa051430.58299923
126Glucagon signaling pathway_Homo sapiens_hsa049220.57352397
127Viral carcinogenesis_Homo sapiens_hsa052030.56893132
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56886964
129Vitamin B6 metabolism_Homo sapiens_hsa007500.55456495
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.55036833
131Renal cell carcinoma_Homo sapiens_hsa052110.54538661
132MAPK signaling pathway_Homo sapiens_hsa040100.53609685
133TNF signaling pathway_Homo sapiens_hsa046680.53198386
134Endometrial cancer_Homo sapiens_hsa052130.52662245
135HTLV-I infection_Homo sapiens_hsa051660.51543975
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.51530125
137Colorectal cancer_Homo sapiens_hsa052100.51368134
138Rheumatoid arthritis_Homo sapiens_hsa053230.50166458
139Prion diseases_Homo sapiens_hsa050200.48502614
140Phototransduction_Homo sapiens_hsa047440.47707468
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.47040083
142Phagosome_Homo sapiens_hsa041450.45685799
143Ras signaling pathway_Homo sapiens_hsa040140.44776951
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44567173
145Pancreatic secretion_Homo sapiens_hsa049720.43538738
146VEGF signaling pathway_Homo sapiens_hsa043700.42514497
147Choline metabolism in cancer_Homo sapiens_hsa052310.41998648
148Dilated cardiomyopathy_Homo sapiens_hsa054140.41273699
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41193043
150Wnt signaling pathway_Homo sapiens_hsa043100.41055245
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40535843
152Prolactin signaling pathway_Homo sapiens_hsa049170.38272605
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38042764
154Butanoate metabolism_Homo sapiens_hsa006500.37997899
155Insulin signaling pathway_Homo sapiens_hsa049100.37714930
156Endocytosis_Homo sapiens_hsa041440.37237336
157Rap1 signaling pathway_Homo sapiens_hsa040150.36986330
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33576840
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.31955440
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31775991
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30650883
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29398113
163Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29020614
164Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28727983
165Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23984477
166Thyroid cancer_Homo sapiens_hsa052160.23113568
167Pyruvate metabolism_Homo sapiens_hsa006200.22377357
168mTOR signaling pathway_Homo sapiens_hsa041500.20990166

Most similar genes based on co-expression Upload to Enrichr

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