NTS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)6.74282508
2ganglion development (GO:0061548)6.34755475
3regulation of triglyceride catabolic process (GO:0010896)5.81598204
4complement activation, alternative pathway (GO:0006957)5.80352940
5cellular response to ATP (GO:0071318)5.75370404
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.67843096
7regulation of cholesterol esterification (GO:0010872)5.63795789
8regulation of bile acid biosynthetic process (GO:0070857)5.23993601
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.19506606
10response to phenylpropanoid (GO:0080184)5.11850160
11locomotory exploration behavior (GO:0035641)5.04498674
12cerebral cortex neuron differentiation (GO:0021895)4.88478977
13epoxygenase P450 pathway (GO:0019373)4.75721053
14cellular glucuronidation (GO:0052695)4.75347324
15uronic acid metabolic process (GO:0006063)4.68778807
16glucuronate metabolic process (GO:0019585)4.68778807
17sympathetic nervous system development (GO:0048485)4.57953714
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.53609748
19midgut development (GO:0007494)4.51411021
20phospholipid efflux (GO:0033700)4.45247772
21exploration behavior (GO:0035640)4.41281370
22plasma lipoprotein particle assembly (GO:0034377)4.40574801
23growth hormone secretion (GO:0030252)4.36249492
24lipoprotein transport (GO:0042953)4.32489185
25glycerophospholipid catabolic process (GO:0046475)4.30443775
26regulation of synaptic vesicle exocytosis (GO:2000300)4.23993105
27positive regulation of growth hormone secretion (GO:0060124)4.22755833
28NADH metabolic process (GO:0006734)4.13918013
29urea metabolic process (GO:0019627)4.13270527
30intestinal absorption (GO:0050892)4.06508061
31primitive streak formation (GO:0090009)4.04795792
32high-density lipoprotein particle remodeling (GO:0034375)4.04005866
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98572094
34regulation of lipoprotein metabolic process (GO:0050746)3.97561706
35positive regulation of lipoprotein lipase activity (GO:0051006)3.96685051
36positive regulation of triglyceride lipase activity (GO:0061365)3.96685051
37regulation of mesoderm development (GO:2000380)3.96372304
38negative regulation of activin receptor signaling pathway (GO:0032926)3.91708964
39flavonoid metabolic process (GO:0009812)3.88473882
40regulation of guanylate cyclase activity (GO:0031282)3.86162506
41activation of protein kinase A activity (GO:0034199)3.83425293
42protein-lipid complex assembly (GO:0065005)3.80935052
43urate metabolic process (GO:0046415)3.78831452
44drug metabolic process (GO:0017144)3.75308185
45regulation of timing of cell differentiation (GO:0048505)3.74789433
46regulation of glucocorticoid secretion (GO:2000849)3.73405745
47fat-soluble vitamin biosynthetic process (GO:0042362)3.73161146
48urea cycle (GO:0000050)3.73132484
49regulation of synaptic vesicle transport (GO:1902803)3.71698400
50negative regulation of dendrite morphogenesis (GO:0050774)3.71101318
51nitrogen cycle metabolic process (GO:0071941)3.70916465
52synaptic vesicle exocytosis (GO:0016079)3.69783860
53female gonad development (GO:0008585)3.67975712
54renal absorption (GO:0070293)3.67778271
55proline transport (GO:0015824)3.67532201
56synaptic vesicle maturation (GO:0016188)3.66483785
57protein localization to microtubule (GO:0035372)3.61539848
58regulation of glycogen (starch) synthase activity (GO:2000465)3.59539590
59anterior/posterior axis specification, embryo (GO:0008595)3.59033257
60vocalization behavior (GO:0071625)3.58076573
61neuron cell-cell adhesion (GO:0007158)3.52472841
62positive regulation of fatty acid biosynthetic process (GO:0045723)3.51586556
63regulation of female receptivity (GO:0045924)3.46290502
64positive regulation of potassium ion transmembrane transport (GO:1901381)3.43625582
65cell migration involved in gastrulation (GO:0042074)3.42670424
66axonal fasciculation (GO:0007413)3.42402418
67neuron recognition (GO:0008038)3.40009261
68removal of superoxide radicals (GO:0019430)3.38753553
69cellular response to superoxide (GO:0071451)3.38753553
70cellular response to oxygen radical (GO:0071450)3.38753553
71regulation of cAMP-dependent protein kinase activity (GO:2000479)3.38291105
72reverse cholesterol transport (GO:0043691)3.35655619
73regulation of cell maturation (GO:1903429)3.35057555
74pyrimidine nucleobase catabolic process (GO:0006208)3.33640449
75positive regulation of hair follicle development (GO:0051798)3.33033642
76positive regulation of hair cycle (GO:0042635)3.33033642
77primary alcohol catabolic process (GO:0034310)3.32250506
78regulation of complement activation (GO:0030449)3.29658517
79neurotransmitter catabolic process (GO:0042135)3.28388289
80drinking behavior (GO:0042756)3.28311053
81keratinocyte proliferation (GO:0043616)3.28154584
82positive regulation of triglyceride metabolic process (GO:0090208)3.26111570
83regulation of protein activation cascade (GO:2000257)3.24194573
84cAMP-mediated signaling (GO:0019933)3.22059242
85regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.20457844
86endocrine process (GO:0050886)3.20457844
87regulation of systemic arterial blood pressure by hormone (GO:0001990)3.20457844
88protein localization to synapse (GO:0035418)3.20347266
89positive regulation of guanylate cyclase activity (GO:0031284)3.18771905
90positive regulation of Cdc42 GTPase activity (GO:0043089)3.18615253
91ER overload response (GO:0006983)3.18516014
92genitalia morphogenesis (GO:0035112)3.16066035
93regulation of development, heterochronic (GO:0040034)3.14276554
94negative regulation of dendrite development (GO:2000171)3.13824436
95neurotransmitter secretion (GO:0007269)3.13227491
96female mating behavior (GO:0060180)3.12582029
97pericardium development (GO:0060039)3.10723573
98regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.10620108
99vitamin transmembrane transport (GO:0035461)3.10557595
100plasma lipoprotein particle remodeling (GO:0034369)3.09911728
101protein-lipid complex remodeling (GO:0034368)3.09911728
102macromolecular complex remodeling (GO:0034367)3.09911728
103proline biosynthetic process (GO:0006561)3.09734657
104multicellular organismal movement (GO:0050879)3.09677703
105musculoskeletal movement (GO:0050881)3.09677703
106maintenance of gastrointestinal epithelium (GO:0030277)3.09358134
107hydrogen peroxide catabolic process (GO:0042744)3.09021359
108hormone catabolic process (GO:0042447)3.07398329
109proline metabolic process (GO:0006560)3.06677870
110cerebral cortex radially oriented cell migration (GO:0021799)3.05836651
111glutamate secretion (GO:0014047)3.05504224
112vitamin A metabolic process (GO:0006776)3.03731229
113negative regulation of epidermal cell differentiation (GO:0045605)3.03698739
114layer formation in cerebral cortex (GO:0021819)3.03646914
115behavioral response to cocaine (GO:0048148)3.03617823
116regulation of corticosteroid hormone secretion (GO:2000846)3.03556679
117cell migration in hindbrain (GO:0021535)3.02252515
118lung secretory cell differentiation (GO:0061140)3.02076523
119positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99944537
120embryonic process involved in female pregnancy (GO:0060136)2.99473920
121positive regulation of glycoprotein biosynthetic process (GO:0010560)2.99261947
122negative regulation of microtubule polymerization (GO:0031115)2.99013921
123positive regulation of lipid catabolic process (GO:0050996)2.98292977
124regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.97579262
125regulation of NFAT protein import into nucleus (GO:0051532)2.97343137
126regulation of glutamate receptor signaling pathway (GO:1900449)2.96187581
127regulation of growth hormone secretion (GO:0060123)2.95954031
128regulation of vesicle fusion (GO:0031338)2.94613123
129GDP-mannose metabolic process (GO:0019673)2.94446026
130nucleobase catabolic process (GO:0046113)2.94079956
131chromatin remodeling at centromere (GO:0031055)2.91902628
132lipoprotein metabolic process (GO:0042157)2.91459259
133mRNA modification (GO:0016556)2.91322216
134glutamine family amino acid biosynthetic process (GO:0009084)2.91174326
135response to hydroperoxide (GO:0033194)2.90966456
136fat-soluble vitamin catabolic process (GO:0042363)2.89768542
137vitamin catabolic process (GO:0009111)2.89768542
138lateral sprouting from an epithelium (GO:0060601)2.89322785
139anterior/posterior axis specification (GO:0009948)2.88060588
140positive regulation of glycoprotein metabolic process (GO:1903020)2.87908239
141neuron fate specification (GO:0048665)2.87490349
142response to folic acid (GO:0051593)2.87462850
143very-low-density lipoprotein particle assembly (GO:0034379)2.87203950
144long-term synaptic potentiation (GO:0060291)2.86567283
145chemosensory behavior (GO:0007635)2.86383141
146epithelial structure maintenance (GO:0010669)2.85521797
147positive regulation of megakaryocyte differentiation (GO:0045654)2.84417935
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83872061
149forebrain neuron differentiation (GO:0021879)2.83834672
150dendritic spine morphogenesis (GO:0060997)2.82750236
151CENP-A containing nucleosome assembly (GO:0034080)2.82644822
152regulation of neuronal synaptic plasticity (GO:0048168)2.82146617
153spinal cord association neuron differentiation (GO:0021527)2.82001986
154regulation of protein kinase A signaling (GO:0010738)2.81536365
155hypothalamus development (GO:0021854)2.80899193
156protein localization to kinetochore (GO:0034501)2.79730057
157regulation of synapse structural plasticity (GO:0051823)2.79502449
158axon extension (GO:0048675)2.78450264
159glomerulus development (GO:0032835)2.75123434
160regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.74715027
161cholesterol homeostasis (GO:0042632)2.74365587
162calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.74323392
163signal transduction involved in regulation of gene expression (GO:0023019)2.73052708
164plasma lipoprotein particle organization (GO:0071827)2.73046848
165SMAD protein complex assembly (GO:0007183)2.72849290
166bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72111117
167sterol homeostasis (GO:0055092)2.72095347
168negative regulation of cell fate specification (GO:0009996)2.71755071
169regulation of systemic arterial blood pressure (GO:0003073)2.71263888
170somite rostral/caudal axis specification (GO:0032525)2.70980459
171dendrite morphogenesis (GO:0048813)2.70908197
172digestion (GO:0007586)2.70330105
173neuroblast proliferation (GO:0007405)2.70264197
174regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67905050
175negative regulation of cardiac muscle hypertrophy (GO:0010614)2.66168591
176neurotransmitter transport (GO:0006836)2.66018676
177regulation of feeding behavior (GO:0060259)2.63208420
178regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62029086
179energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61034477
180ATP hydrolysis coupled proton transport (GO:0015991)2.61034477
181neuron projection extension (GO:1990138)2.60559832
182regulation of glutamate secretion (GO:0014048)2.60328956
183regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59759724
184glutamate receptor signaling pathway (GO:0007215)2.57224303
185positive regulation of potassium ion transport (GO:0043268)2.56371401
186synaptic vesicle endocytosis (GO:0048488)2.56003674
187reflex (GO:0060004)2.55412268
188positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.55406544
189ionotropic glutamate receptor signaling pathway (GO:0035235)2.54563394
190regulation of postsynaptic membrane potential (GO:0060078)2.54174511
191regulation of dendritic spine morphogenesis (GO:0061001)2.53067967
192dendrite development (GO:0016358)2.53059722
193neuron-neuron synaptic transmission (GO:0007270)2.51330793
194synapse assembly (GO:0007416)2.49639318
195response to ATP (GO:0033198)2.49274880
196neurotransmitter-gated ion channel clustering (GO:0072578)2.49056072
197embryonic heart tube development (GO:0035050)2.47457703
198synaptic transmission, glutamatergic (GO:0035249)2.47296837
199adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.44455719
200establishment of mitochondrion localization (GO:0051654)2.44117260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.42555155
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.27166902
3AR_21909140_ChIP-Seq_LNCAP_Human3.98840207
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.73381340
5EZH2_22144423_ChIP-Seq_EOC_Human3.59430424
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49199246
7GBX2_23144817_ChIP-Seq_PC3_Human3.02340575
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.01855871
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94350684
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.94169337
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84771456
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79864501
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76662200
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70872518
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66558616
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50705486
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44286939
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44286939
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43609379
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43113887
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.42447621
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37867417
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.34629827
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33946129
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33751051
26REST_21632747_ChIP-Seq_MESCs_Mouse2.33258759
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.33076993
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32750273
29MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32423210
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.26786987
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23009583
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20939400
33CLOCK_20551151_ChIP-Seq_293T_Human2.16060901
34DROSHA_22980978_ChIP-Seq_HELA_Human2.15540885
35PPARA_22158963_ChIP-Seq_LIVER_Mouse2.13728305
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.13129168
37NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.07706188
38NANOG_16153702_ChIP-ChIP_HESCs_Human2.01574056
39RXR_22158963_ChIP-Seq_LIVER_Mouse2.01258278
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97865334
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96467733
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.95324100
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94274481
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94274481
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94274481
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92184684
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92021244
48GATA4_25053715_ChIP-Seq_YYC3_Human1.91396405
49* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90798165
50TAF15_26573619_Chip-Seq_HEK293_Human1.89744104
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.89679390
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87308537
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86669876
54GATA6_25053715_ChIP-Seq_YYC3_Human1.84074023
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82758196
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80687380
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79995276
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79157314
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78694677
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77853523
61* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77828761
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76077825
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.75094362
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74388514
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.74380725
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68727749
67AR_21572438_ChIP-Seq_LNCaP_Human1.66381936
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.65893965
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.65507071
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65470039
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.65061759
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63033084
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61560394
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59416300
75SMAD4_21799915_ChIP-Seq_A2780_Human1.59401517
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58379110
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57414776
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.56437434
79IGF1R_20145208_ChIP-Seq_DFB_Human1.55223482
80P300_19829295_ChIP-Seq_ESCs_Human1.52330607
81* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50416397
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.49278040
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.48548980
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48075973
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.47850554
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47677128
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44586022
88* AR_25329375_ChIP-Seq_VCAP_Human1.41472862
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41300905
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38831130
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38539189
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38410481
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38034632
94SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37339619
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36710684
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36323056
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36243519
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35317645
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34978067
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33806211
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.33166957
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.32630070
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32489480
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.32363103
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29543477
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.29116986
107* TRIM28_21343339_ChIP-Seq_HEK293_Human1.28735175
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27262802
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24855995
110DCP1A_22483619_ChIP-Seq_HELA_Human1.22950304
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22840157
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22707527
113TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22293371
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21687638
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20094520
116JUN_21703547_ChIP-Seq_K562_Human1.18411331
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18313952
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.18043844
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17581996
120RNF2_27304074_Chip-Seq_NSC_Mouse1.16947575
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.16865503
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16320369
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16233276
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.15567473
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15530353
126ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15343314
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15135299
128NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14728956
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13710117
130FUS_26573619_Chip-Seq_HEK293_Human1.13493624
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13064068
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.13051203
133EST1_17652178_ChIP-ChIP_JURKAT_Human1.12724737
134OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11623914
135RING1B_27294783_Chip-Seq_NPCs_Mouse1.11112872
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10042607
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09886766
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09273612
139XRN2_22483619_ChIP-Seq_HELA_Human1.09060968
140POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08957023
141ELK1_19687146_ChIP-ChIP_HELA_Human1.08461613
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08399786
143CBP_20019798_ChIP-Seq_JUKART_Human1.08222819
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08222819
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07669913
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07593939
147EOMES_21245162_ChIP-Seq_HESCs_Human1.07591366
148SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07441273
149VDR_22108803_ChIP-Seq_LS180_Human1.07278034
150RUNX2_22187159_ChIP-Seq_PCA_Human1.06998815
151STAT3_23295773_ChIP-Seq_U87_Human1.06312694
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06100552
153MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03700895
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03695466
155TCF4_23295773_ChIP-Seq_U87_Human1.03076059
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02941985
157KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02754583
158SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02611053
159E2F1_21310950_ChIP-Seq_MCF-7_Human1.02584670
160RXR_22108803_ChIP-Seq_LS180_Human1.01422214
161KDM2B_26808549_Chip-Seq_REH_Human1.01302583
162MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01153280
163TP63_19390658_ChIP-ChIP_HaCaT_Human1.01070401
164WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00687460
165ZNF274_21170338_ChIP-Seq_K562_Hela1.00334285
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99103123
167AR_19668381_ChIP-Seq_PC3_Human0.98121187
168EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97165464
169ESR1_20079471_ChIP-ChIP_T-47D_Human0.95952140
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95481580
171* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95291157
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94006631
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93764457
174TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93316778
175ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93303213
176ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93162353
177AHR_22903824_ChIP-Seq_MCF-7_Human0.92670658
178ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92397054
179OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91718333
180TTF2_22483619_ChIP-Seq_HELA_Human0.91360494
181STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91343190
182ARNT_22903824_ChIP-Seq_MCF-7_Human0.90924552
183CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90678325
184KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90128421
185SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89611586
186* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89264728
187JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88624576
188KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88002234
189TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86251174
190SOX2_20726797_ChIP-Seq_SW620_Human0.86127370
191BCAT_22108803_ChIP-Seq_LS180_Human0.85954511
192FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83887610
193ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83196143
194ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82246774
195HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81217523
196CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79917399
197SOX2_22085726_ChIP-Seq_NPCs_Mouse0.79411194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.09196934
2MP0001986_abnormal_taste_sensitivity5.18424408
3MP0003890_abnormal_embryonic-extraembry3.96994499
4MP0002735_abnormal_chemical_nociception3.91645591
5MP0009840_abnormal_foam_cell3.90165029
6MP0001666_abnormal_nutrient_absorption3.75959804
7MP0004859_abnormal_synaptic_plasticity3.64603952
8MP0005085_abnormal_gallbladder_physiolo3.59548630
9MP0004264_abnormal_extraembryonic_tissu3.44943268
10MP0004270_analgesia3.43241808
11MP0004858_abnormal_nervous_system3.41792583
12MP0003880_abnormal_central_pattern3.33294084
13MP0002876_abnormal_thyroid_physiology3.30816906
14MP0001968_abnormal_touch/_nociception3.22921929
15MP0009780_abnormal_chondrocyte_physiolo3.04822059
16MP0004019_abnormal_vitamin_homeostasis3.03134509
17MP0005365_abnormal_bile_salt2.95110405
18MP0002734_abnormal_mechanical_nocicepti2.87839856
19MP0005646_abnormal_pituitary_gland2.85037650
20MP0003635_abnormal_synaptic_transmissio2.75833618
21MP0008789_abnormal_olfactory_epithelium2.70455480
22MP0004957_abnormal_blastocyst_morpholog2.68061464
23MP0006276_abnormal_autonomic_nervous2.62463104
24MP0003693_abnormal_embryo_hatching2.45174529
25MP0005499_abnormal_olfactory_system2.40102520
26MP0005394_taste/olfaction_phenotype2.40102520
27MP0002063_abnormal_learning/memory/cond2.38347610
28MP0002733_abnormal_thermal_nociception2.37122444
29MP0002254_reproductive_system_inflammat2.30214028
30MP0009745_abnormal_behavioral_response2.28955499
31MP0002796_impaired_skin_barrier2.26404956
32MP0003119_abnormal_digestive_system2.22912167
33MP0002139_abnormal_hepatobiliary_system2.17681061
34MP0001501_abnormal_sleep_pattern2.13230772
35MP0003941_abnormal_skin_development2.11501876
36MP0009379_abnormal_foot_pigmentation2.08121073
37MP0002064_seizures2.07346754
38MP0000566_synostosis1.99446535
39MP0009046_muscle_twitch1.99195145
40MP0001440_abnormal_grooming_behavior1.98107934
41MP0001970_abnormal_pain_threshold1.93135065
42MP0005645_abnormal_hypothalamus_physiol1.92151220
43MP0005423_abnormal_somatic_nervous1.88616179
44MP0002909_abnormal_adrenal_gland1.85014691
45MP0002572_abnormal_emotion/affect_behav1.84703139
46MP0002272_abnormal_nervous_system1.84359987
47MP0002751_abnormal_autonomic_nervous1.84275887
48MP0001346_abnormal_lacrimal_gland1.76358721
49MP0002067_abnormal_sensory_capabilities1.74921885
50MP0003718_maternal_effect1.72543963
51MP0010329_abnormal_lipoprotein_level1.70633694
52MP0006072_abnormal_retinal_apoptosis1.69062390
53MP0002163_abnormal_gland_morphology1.67664250
54MP0004811_abnormal_neuron_physiology1.67216310
55MP0002736_abnormal_nociception_after1.66914414
56MP0003806_abnormal_nucleotide_metabolis1.61689415
57MP0003122_maternal_imprinting1.57202340
58MP0005332_abnormal_amino_acid1.56335207
59MP0005379_endocrine/exocrine_gland_phen1.53045222
60MP0001730_embryonic_growth_arrest1.50994463
61MP0001486_abnormal_startle_reflex1.43782896
62MP0008932_abnormal_embryonic_tissue1.43756976
63MP0002111_abnormal_tail_morphology1.42704429
64MP0003329_amyloid_beta_deposits1.42263704
65MP0002184_abnormal_innervation1.37466648
66MP0009697_abnormal_copulation1.36939585
67MP0001348_abnormal_lacrimal_gland1.36241854
68MP0000778_abnormal_nervous_system1.36040515
69MP0010094_abnormal_chromosome_stability1.33746562
70MP0003787_abnormal_imprinting1.33030357
71MP0004924_abnormal_behavior1.30359591
72MP0005386_behavior/neurological_phenoty1.30359591
73MP0000490_abnormal_crypts_of1.28192934
74MP0004142_abnormal_muscle_tone1.27636317
75MP0003879_abnormal_hair_cell1.27446799
76MP0000631_abnormal_neuroendocrine_gland1.26969011
77MP0006054_spinal_hemorrhage1.26820707
78MP0003937_abnormal_limbs/digits/tail_de1.26528400
79MP0000955_abnormal_spinal_cord1.25483515
80MP0003690_abnormal_glial_cell1.23867829
81MP0003567_abnormal_fetal_cardiomyocyte1.23508553
82MP0003183_abnormal_peptide_metabolism1.23042032
83MP0002557_abnormal_social/conspecific_i1.22819724
84MP0002084_abnormal_developmental_patter1.21471570
85MP0003195_calcinosis1.19707934
86MP0005257_abnormal_intraocular_pressure1.17604577
87MP0002882_abnormal_neuron_morphology1.16224408
88MP0005380_embryogenesis_phenotype1.15843729
89MP0001672_abnormal_embryogenesis/_devel1.15843729
90MP0001529_abnormal_vocalization1.15451793
91MP0001299_abnormal_eye_distance/1.15409012
92MP0000751_myopathy1.15105149
93MP0010030_abnormal_orbit_morphology1.14510875
94MP0001293_anophthalmia1.13873308
95MP0003111_abnormal_nucleus_morphology1.12196238
96MP0001188_hyperpigmentation1.07354173
97MP0005501_abnormal_skin_physiology1.07334432
98MP0002249_abnormal_larynx_morphology1.06604737
99MP0005670_abnormal_white_adipose1.06253674
100MP0009672_abnormal_birth_weight1.05770576
101MP0001764_abnormal_homeostasis1.04604593
102MP0001984_abnormal_olfaction1.04418391
103MP0000462_abnormal_digestive_system1.03887997
104MP0003633_abnormal_nervous_system1.03776186
105MP0002089_abnormal_postnatal_growth/wei1.03544194
106MP0002066_abnormal_motor_capabilities/c1.02699009
107MP0002085_abnormal_embryonic_tissue1.02683269
108MP0010155_abnormal_intestine_physiology1.01908689
109MP0004484_altered_response_of1.01012159
110MP0003959_abnormal_lean_body1.00599001
111MP0000678_abnormal_parathyroid_gland0.99201611
112MP0000467_abnormal_esophagus_morphology0.99171056
113MP0002086_abnormal_extraembryonic_tissu0.99059752
114MP0003634_abnormal_glial_cell0.98971716
115MP0002098_abnormal_vibrissa_morphology0.97039112
116MP0002069_abnormal_eating/drinking_beha0.96996043
117MP0001485_abnormal_pinna_reflex0.96575291
118MP0005666_abnormal_adipose_tissue0.95435434
119MP0004185_abnormal_adipocyte_glucose0.94736932
120MP0002233_abnormal_nose_morphology0.94566279
121MP0002822_catalepsy0.94259775
122MP0009643_abnormal_urine_homeostasis0.93784531
123MP0009384_cardiac_valve_regurgitation0.92466124
124MP0003077_abnormal_cell_cycle0.91544208
125* MP0008872_abnormal_physiological_respon0.91154724
126MP0003868_abnormal_feces_composition0.90678902
127MP0000477_abnormal_intestine_morphology0.90522890
128MP0002837_dystrophic_cardiac_calcinosis0.90350916
129MP0000538_abnormal_urinary_bladder0.88436148
130MP0000049_abnormal_middle_ear0.88114745
131MP0003984_embryonic_growth_retardation0.87139377
132MP0008569_lethality_at_weaning0.85676248
133MP0010234_abnormal_vibrissa_follicle0.84300096
134MP0004782_abnormal_surfactant_physiolog0.84259975
135MP0002088_abnormal_embryonic_growth/wei0.83419390
136MP0001905_abnormal_dopamine_level0.82799447
137MP0008875_abnormal_xenobiotic_pharmacok0.81727091
138MP0000762_abnormal_tongue_morphology0.80173908
139MP0004885_abnormal_endolymph0.79732484
140MP0000604_amyloidosis0.79718515
141MP0002080_prenatal_lethality0.78654128
142MP0008874_decreased_physiological_sensi0.78450508
143MP0001697_abnormal_embryo_size0.77882881
144MP0002932_abnormal_joint_morphology0.77163074
145MP0005408_hypopigmentation0.75847564
146MP0005636_abnormal_mineral_homeostasis0.75689345
147MP0008057_abnormal_DNA_replication0.74787015
148MP0002229_neurodegeneration0.74147862
149MP0003724_increased_susceptibility_to0.74096262
150MP0004215_abnormal_myocardial_fiber0.73808930
151MP0001849_ear_inflammation0.73274805
152MP0004742_abnormal_vestibular_system0.73232149
153MP0002152_abnormal_brain_morphology0.72376231
154MP0000427_abnormal_hair_cycle0.71951904
155MP0009053_abnormal_anal_canal0.69101707
156MP0001664_abnormal_digestion0.67996004
157MP0001177_atelectasis0.67580301
158MP0001286_abnormal_eye_development0.66617652
159MP0003631_nervous_system_phenotype0.66430353
160MP0000920_abnormal_myelination0.65945310
161MP0005647_abnormal_sex_gland0.65348326
162MP0004085_abnormal_heartbeat0.65330943
163MP0002971_abnormal_brown_adipose0.65137248
164MP0006138_congestive_heart_failure0.64637666
165MP0001943_abnormal_respiration0.64469250
166MP0008260_abnormal_autophagy0.64221743
167MP0000350_abnormal_cell_proliferation0.64036265
168MP0002282_abnormal_trachea_morphology0.63906807
169MP0001963_abnormal_hearing_physiology0.63807618
170MP0010678_abnormal_skin_adnexa0.63341305
171MP0003121_genomic_imprinting0.63185156
172MP0005395_other_phenotype0.62972682
173MP0000432_abnormal_head_morphology0.62782456
174MP0009250_abnormal_appendicular_skeleto0.61582378
175MP0001216_abnormal_epidermal_layer0.61280599
176MP0002752_abnormal_somatic_nervous0.60648874
177MP0005319_abnormal_enzyme/_coenzyme0.60029499
178MP0004197_abnormal_fetal_growth/weight/0.59333125
179MP0005448_abnormal_energy_balance0.58384604
180MP0005409_darkened_coat_color0.57678389
181MP0008775_abnormal_heart_ventricle0.57569152
182MP0000537_abnormal_urethra_morphology0.57342314
183MP0010352_gastrointestinal_tract_polyps0.56628148
184MP0004147_increased_porphyrin_level0.55635700
185MP0004145_abnormal_muscle_electrophysio0.55483259
186MP0000639_abnormal_adrenal_gland0.53789446

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.34477869
2Hypoventilation (HP:0002791)5.24091636
3Hypobetalipoproteinemia (HP:0003563)5.23353269
4Abnormality of proline metabolism (HP:0010907)5.01894248
5Hydroxyprolinuria (HP:0003080)5.01894248
6Congenital malformation of the right heart (HP:0011723)4.82436697
7Double outlet right ventricle (HP:0001719)4.82436697
8Myokymia (HP:0002411)4.48182099
9Hypercortisolism (HP:0001578)4.30556488
10Pheochromocytoma (HP:0002666)4.30161755
11Visual hallucinations (HP:0002367)4.10647445
12Termporal pattern (HP:0011008)4.09158011
13Insidious onset (HP:0003587)4.09158011
14Malnutrition (HP:0004395)4.06913286
15Abnormality of the vitamin B12 metabolism (HP:0004341)3.87465818
16Acanthocytosis (HP:0001927)3.86725825
17Abnormal umbilical cord blood vessels (HP:0011403)3.84469140
18Single umbilical artery (HP:0001195)3.84469140
19Abnormality of the fetal cardiovascular system (HP:0010948)3.84469140
20Gout (HP:0001997)3.77372947
21Neuroendocrine neoplasm (HP:0100634)3.70773141
22Focal motor seizures (HP:0011153)3.69347636
23Focal seizures (HP:0007359)3.64638596
24Abnormality of vitamin B metabolism (HP:0004340)3.49334775
25Hyperglycinuria (HP:0003108)3.45366784
26Abnormality of the corticospinal tract (HP:0002492)3.44930123
27Atonic seizures (HP:0010819)3.42243701
28Abnormality of glycine metabolism (HP:0010895)3.32099356
29Abnormality of serine family amino acid metabolism (HP:0010894)3.32099356
30Fat malabsorption (HP:0002630)3.26341074
31Widely patent fontanelles and sutures (HP:0004492)3.22304784
32Megaloblastic anemia (HP:0001889)3.19452206
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.18469002
34Degeneration of the lateral corticospinal tracts (HP:0002314)3.18469002
35Absence seizures (HP:0002121)3.13057838
36Peripheral primitive neuroectodermal neoplasm (HP:0030067)3.08561555
37Neuroblastoma (HP:0003006)3.08561555
38Primitive neuroectodermal tumor (HP:0030065)3.08561555
39Neuroblastic tumors (HP:0004376)3.08561555
40Generalized tonic-clonic seizures (HP:0002069)3.08510178
41Hypoplastic labia majora (HP:0000059)3.02479635
42Ankle clonus (HP:0011448)2.97935127
43Urinary urgency (HP:0000012)2.95867743
44Hyperuricemia (HP:0002149)2.94844571
45Increased purine levels (HP:0004368)2.94844571
46Abnormality of the umbilical cord (HP:0010881)2.91291865
47Nausea (HP:0002018)2.90058856
48Impaired vibration sensation in the lower limbs (HP:0002166)2.89902100
49Lower limb muscle weakness (HP:0007340)2.88893695
50Failure to thrive in infancy (HP:0001531)2.87650810
51Truncus arteriosus (HP:0001660)2.87249279
52Ulnar claw (HP:0001178)2.79463623
53Resting tremor (HP:0002322)2.75866472
54Abnormality of vitamin metabolism (HP:0100508)2.75279443
55Hypolipoproteinemia (HP:0010981)2.74398579
56Abnormal pancreas size (HP:0012094)2.73679201
57Glycosuria (HP:0003076)2.72194642
58Abnormality of urine glucose concentration (HP:0011016)2.72194642
59Progressive inability to walk (HP:0002505)2.71996579
60Abnormal hair laboratory examination (HP:0003328)2.71688658
61Cerebral palsy (HP:0100021)2.68889469
62Akinesia (HP:0002304)2.68660648
63Agitation (HP:0000713)2.67615648
64Abnormality of the labia majora (HP:0012881)2.66825900
65Poor eye contact (HP:0000817)2.64119891
66Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.61055905
67Xanthomatosis (HP:0000991)2.57332769
68Urinary bladder sphincter dysfunction (HP:0002839)2.56854763
69Spastic gait (HP:0002064)2.56617003
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54622438
71Lower limb amyotrophy (HP:0007210)2.49243244
72Confusion (HP:0001289)2.48908207
73Epileptic encephalopathy (HP:0200134)2.47633938
74Selective tooth agenesis (HP:0001592)2.47109238
75Enlarged kidneys (HP:0000105)2.45939156
76Polyphagia (HP:0002591)2.45289670
77Abnormal social behavior (HP:0012433)2.45020752
78Impaired social interactions (HP:0000735)2.45020752
79Dialeptic seizures (HP:0011146)2.44538600
80Abnormal eating behavior (HP:0100738)2.43938908
81Supranuclear gaze palsy (HP:0000605)2.41761077
82Labial hypoplasia (HP:0000066)2.40161994
83Aplasia involving bones of the upper limbs (HP:0009823)2.40049159
84Aplasia of the phalanges of the hand (HP:0009802)2.40049159
85Aplasia involving bones of the extremities (HP:0009825)2.40049159
86Nervous tissue neoplasm (HP:0030060)2.37939311
87Neuroectodermal neoplasm (HP:0030061)2.37939311
88Neuroepithelial neoplasm (HP:0030063)2.37939311
89Abnormality of the salivary glands (HP:0010286)2.37177749
90Hypoplastic female external genitalia (HP:0012815)2.34501581
91Posterior subcapsular cataract (HP:0007787)2.32527467
92Neoplasm of the peripheral nervous system (HP:0100007)2.32382131
93Delayed CNS myelination (HP:0002188)2.31678005
94Ileus (HP:0002595)2.31027166
95Abnormality of serum amino acid levels (HP:0003112)2.29739115
96Action tremor (HP:0002345)2.27985524
97Ureteral duplication (HP:0000073)2.27561630
98Gait imbalance (HP:0002141)2.26007830
99Psychosis (HP:0000709)2.25768753
100Wide cranial sutures (HP:0010537)2.23892087
101Hypoglycemic coma (HP:0001325)2.21972460
102Fibular aplasia (HP:0002990)2.21828476
103Cerebral inclusion bodies (HP:0100314)2.21077448
104Vertebral arch anomaly (HP:0008438)2.20650105
105Pigmentary retinal degeneration (HP:0001146)2.18573666
106Anxiety (HP:0000739)2.18513263
107Ventricular fibrillation (HP:0001663)2.18126689
108Febrile seizures (HP:0002373)2.18006894
109Abnormalities of placenta or umbilical cord (HP:0001194)2.16987921
110Intrahepatic cholestasis (HP:0001406)2.16900531
111Abnormality of pain sensation (HP:0010832)2.15934799
112Impaired pain sensation (HP:0007328)2.15934799
113Abnormality of purine metabolism (HP:0004352)2.15813634
114Excessive salivation (HP:0003781)2.15666780
115Drooling (HP:0002307)2.15666780
116Anal stenosis (HP:0002025)2.14802868
117Steatorrhea (HP:0002570)2.14535812
118Abnormality of salivation (HP:0100755)2.14359011
119Poor suck (HP:0002033)2.13224922
120Xerostomia (HP:0000217)2.11743472
121Progressive cerebellar ataxia (HP:0002073)2.10641006
122Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10555947
123Conjunctival hamartoma (HP:0100780)2.09915984
124Adrenal overactivity (HP:0002717)2.09713856
125Proximal placement of thumb (HP:0009623)2.08049417
126Increased serum pyruvate (HP:0003542)2.07907485
127Abnormality of calcium-phosphate metabolism (HP:0100530)2.07764623
128Chronic diarrhea (HP:0002028)2.07031130
129Absent eyelashes (HP:0000561)2.06175539
130Breast hypoplasia (HP:0003187)2.06157176
131Short middle phalanx of the 5th finger (HP:0004220)2.06136481
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05564623
133Muscle fibrillation (HP:0010546)2.05412244
134Myelomeningocele (HP:0002475)2.05264816
135Hypothermia (HP:0002045)2.05056496
136Potter facies (HP:0002009)2.04952981
137Facial shape deformation (HP:0011334)2.04952981
138Deviation of the thumb (HP:0009603)2.04720931
139Abnormal hair whorl (HP:0010721)2.04352040
140Malignant neoplasm of the central nervous system (HP:0100836)2.02974061
141Growth hormone deficiency (HP:0000824)2.02651497
142Abnormality of abdominal situs (HP:0011620)2.01603298
143Abdominal situs inversus (HP:0003363)2.01603298
144Abnormality of the axillary hair (HP:0100134)2.00150919
145Abnormality of secondary sexual hair (HP:0009888)2.00150919
146Back pain (HP:0003418)1.99382152
147Abnormality of the lumbar spine (HP:0100712)1.99301678
148Cerebral hemorrhage (HP:0001342)1.98381867
149Exotropia (HP:0000577)1.98320226
150Abnormality of nucleobase metabolism (HP:0010932)1.98054976
151Tongue fasciculations (HP:0001308)1.97002291
152Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96976336
153Right ventricular cardiomyopathy (HP:0011663)1.96308256
154Upper limb muscle weakness (HP:0003484)1.96305439
155Goiter (HP:0000853)1.96084942
156EEG with generalized epileptiform discharges (HP:0011198)1.95014634
157Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.94467171
158Vascular calcification (HP:0004934)1.94451367
159Nephrolithiasis (HP:0000787)1.94417393
160Hypoplasia of the uterus (HP:0000013)1.94037358
161Neurofibrillary tangles (HP:0002185)1.93626848
162Scanning speech (HP:0002168)1.93357675
163Cavernous hemangioma (HP:0001048)1.93127036
164Glomerulonephritis (HP:0000099)1.92550684
165Hypsarrhythmia (HP:0002521)1.91513607
166Hypoglycemic seizures (HP:0002173)1.90268753
167Dysdiadochokinesis (HP:0002075)1.90002679
168Abnormality of the labia (HP:0000058)1.90002617
169Hyperactive renin-angiotensin system (HP:0000841)1.89087480
170Epileptiform EEG discharges (HP:0011182)1.88948084
171Vaginal fistula (HP:0004320)1.87625457
172Abnormality of the vocal cords (HP:0008777)1.87533059
173Broad-based gait (HP:0002136)1.86852041
174Proximal tubulopathy (HP:0000114)1.86087893
175Mucosal telangiectasiae (HP:0100579)1.85581504
176Pili torti (HP:0003777)1.85518172
177Split foot (HP:0001839)1.84689422
178Abnormality of the anterior horn cell (HP:0006802)1.84676864
179Degeneration of anterior horn cells (HP:0002398)1.84676864
180Hamartoma of the eye (HP:0010568)1.84312944
181Neoplasm of the adrenal gland (HP:0100631)1.83873687
182Abnormality of glycolysis (HP:0004366)1.83046318
183Focal segmental glomerulosclerosis (HP:0000097)1.83034705
184Depression (HP:0000716)1.82827997
185Abdominal distention (HP:0003270)1.82491998
186Hyperammonemia (HP:0001987)1.82151952
187Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81815471
188Absent radius (HP:0003974)1.81006846
189Hyperphosphaturia (HP:0003109)1.80283444
190Abnormal lung lobation (HP:0002101)1.79720560
191Systemic lupus erythematosus (HP:0002725)1.78496632
192Sparse eyelashes (HP:0000653)1.76999458
193Abnormality of sulfur amino acid metabolism (HP:0004339)1.75844759
194Popliteal pterygium (HP:0009756)1.75213374
195Symptomatic seizures (HP:0011145)1.74721217
196Complement deficiency (HP:0004431)1.74644171
197Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74565356
198Abnormal urine phosphate concentration (HP:0012599)1.74558090
199Abnormality of the middle phalanges of the toes (HP:0010183)1.73623542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.41752378
2PLK43.84373393
3MST1R3.46378615
4ERBB33.35608832
5TSSK63.23646156
6MARK13.12956779
7MST43.04219479
8WEE13.00052569
9MKNK22.95144381
10PDK22.90310958
11TTK2.85628017
12MAP3K122.82954043
13MAP3K92.82759262
14CASK2.68091478
15NTRK32.53573024
16ARAF2.49775487
17PBK2.44355069
18MINK12.41930158
19MAP3K102.41314692
20SRPK12.38397300
21TNIK2.34665312
22TRIM282.27005237
23SCYL22.15620246
24PAK62.11104649
25MKNK12.10798340
26SGK2231.92637684
27SGK4941.92637684
28MAP2K71.91703517
29PAK31.86153046
30NTRK11.80007185
31BUB11.79031464
32PLK21.78590102
33EPHA41.75048652
34SGK21.69991652
35MAP3K41.67472455
36LMTK21.66334381
37AKT31.66088050
38PLK31.65021584
39FER1.63643417
40MET1.60881606
41EPHA31.59163544
42PIM21.58331652
43CDC71.53844456
44EIF2AK31.53196767
45PAK41.49018339
46BMPR1B1.48222308
47EPHA21.46316147
48MAP3K131.45267198
49BRSK21.44568590
50DYRK21.43275716
51LIMK11.42863367
52GRK51.40838216
53ZAK1.35263322
54MAP2K11.31896667
55DAPK21.29794403
56PRKG21.24217345
57SGK31.22727772
58CDK51.19031654
59RPS6KA21.16193001
60KSR21.14950005
61OXSR11.14948521
62PRKCH1.14854422
63BCR1.14390457
64PLK11.10613120
65EIF2AK11.10040733
66PRKCI1.06746240
67MAPK131.06434446
68MAP2K41.04913115
69MAPK151.04659423
70NTRK21.04404940
71PHKG11.00436131
72PHKG21.00436131
73WNK31.00294836
74PRKCE0.98947445
75MAP3K140.97339115
76STK240.96497855
77FGFR10.94353895
78KSR10.94179230
79RIPK40.91286999
80CDK60.90535604
81CSNK1G20.87830696
82NME10.87353081
83CAMKK10.86883038
84MAP3K80.85927979
85PRKCG0.85739311
86UHMK10.84664638
87ADRBK10.84120648
88NEK60.80470428
89CAMKK20.77836069
90PNCK0.76929493
91CDC42BPA0.76834524
92STK160.76548955
93MELK0.71820795
94PTK60.71551170
95CAMK2A0.71041776
96NLK0.70389566
97RET0.70280421
98SIK30.70030452
99VRK10.68934831
100STK100.68527475
101STK390.67818323
102BRAF0.64889516
103TLK10.64238916
104MAP3K10.63445111
105MYLK0.63275537
106NEK10.63222459
107EIF2AK20.61642029
108AURKB0.61633978
109ERBB20.60361607
110RAF10.60209347
111CAMK2G0.60089505
112TAF10.59748442
113ERBB40.59377122
114RIPK10.59328067
115MAP2K20.58012077
116WNK10.57583526
117TIE10.57528041
118SMG10.56608989
119DMPK0.56600001
120BRSK10.55941468
121PRPF4B0.55823790
122KDR0.55168149
123TYRO30.54399779
124RPS6KB10.54198737
125CSNK1G30.53999564
126CDK140.53869075
127LATS20.52582328
128ALK0.52284933
129DAPK10.52148871
130RPS6KB20.51646760
131PRKD30.50496707
132MAP3K20.49415029
133SGK10.48993055
134CDK30.48718569
135CAMK2B0.48255781
136CAMK2D0.48237813
137PRKAA20.47718063
138GRK60.47440199
139NEK20.47378155
140ROCK20.45614826
141GRK10.45453220
142TGFBR10.45444813
143EPHB20.45240961
144JAK30.45234422
145PTK2B0.44963264
146CSNK1A1L0.43139453
147EPHB10.41515370
148PTK20.41184234
149LATS10.40986191
150STK110.40379269
151BMPR20.40259801
152PRKCQ0.40194890
153DDR20.39363678
154CDK70.38942277
155PRKCB0.38168671
156CHEK20.38103389
157MAP2K60.36893877
158CSNK1E0.36573387
159FLT30.36500368
160PRKCZ0.35631023
161CDK180.35355458
162MAPKAPK30.34732712
163NUAK10.33366908
164SRC0.33156907
165SIK10.32643208
166CSNK2A10.31176580
167ATR0.29456127
168FGFR40.29068940
169STK30.28930738
170DYRK30.27941132
171NME20.27279998
172YES10.26415986
173CHEK10.25985487
174STK40.24170702
175ATM0.23811183
176CDK190.23420675
177CSNK2A20.22861673

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049774.54311534
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.22460248
3Fat digestion and absorption_Homo sapiens_hsa049753.77673624
4Synaptic vesicle cycle_Homo sapiens_hsa047213.39098911
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07093896
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.99827539
7Renin-angiotensin system_Homo sapiens_hsa046142.84237632
8Nicotine addiction_Homo sapiens_hsa050332.77753060
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.76219589
10Starch and sucrose metabolism_Homo sapiens_hsa005002.46412853
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.32527485
12Retinol metabolism_Homo sapiens_hsa008302.31666583
13Chemical carcinogenesis_Homo sapiens_hsa052042.28110664
14GABAergic synapse_Homo sapiens_hsa047272.28034785
15Olfactory transduction_Homo sapiens_hsa047402.21810678
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.21506983
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.17416488
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15322480
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11054183
20Circadian entrainment_Homo sapiens_hsa047132.02673389
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02010709
22Morphine addiction_Homo sapiens_hsa050321.99411231
23Glutamatergic synapse_Homo sapiens_hsa047241.91257059
24Collecting duct acid secretion_Homo sapiens_hsa049661.91194624
25Caffeine metabolism_Homo sapiens_hsa002321.90681575
26Galactose metabolism_Homo sapiens_hsa000521.87980890
27Histidine metabolism_Homo sapiens_hsa003401.82164402
28Long-term potentiation_Homo sapiens_hsa047201.81513663
29Dopaminergic synapse_Homo sapiens_hsa047281.78035074
30Protein digestion and absorption_Homo sapiens_hsa049741.77918568
31Oxidative phosphorylation_Homo sapiens_hsa001901.77485832
32Taste transduction_Homo sapiens_hsa047421.74566794
33Proteasome_Homo sapiens_hsa030501.71645378
34Cholinergic synapse_Homo sapiens_hsa047251.66904358
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.64871771
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61678841
37Parkinsons disease_Homo sapiens_hsa050121.58143522
38Insulin secretion_Homo sapiens_hsa049111.54497335
39Long-term depression_Homo sapiens_hsa047301.53799969
40Serotonergic synapse_Homo sapiens_hsa047261.53657541
41Vibrio cholerae infection_Homo sapiens_hsa051101.52180630
42Fatty acid degradation_Homo sapiens_hsa000711.49800379
43Amphetamine addiction_Homo sapiens_hsa050311.46733118
44Gastric acid secretion_Homo sapiens_hsa049711.41122234
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40108076
46Glutathione metabolism_Homo sapiens_hsa004801.40038709
47Salivary secretion_Homo sapiens_hsa049701.39276444
48Axon guidance_Homo sapiens_hsa043601.38998810
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38486981
50Linoleic acid metabolism_Homo sapiens_hsa005911.35909436
51Dorso-ventral axis formation_Homo sapiens_hsa043201.33822960
52Cocaine addiction_Homo sapiens_hsa050301.31030830
53Alzheimers disease_Homo sapiens_hsa050101.30857482
54Phenylalanine metabolism_Homo sapiens_hsa003601.30365620
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28827544
56Biosynthesis of amino acids_Homo sapiens_hsa012301.27831257
57Renin secretion_Homo sapiens_hsa049241.27454568
58Fructose and mannose metabolism_Homo sapiens_hsa000511.27297954
59ErbB signaling pathway_Homo sapiens_hsa040121.26057857
60PPAR signaling pathway_Homo sapiens_hsa033201.25924515
61Mineral absorption_Homo sapiens_hsa049781.22255029
62Arginine and proline metabolism_Homo sapiens_hsa003301.21675801
63Gap junction_Homo sapiens_hsa045401.21141450
64Cardiac muscle contraction_Homo sapiens_hsa042601.20686995
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17472273
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15288071
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13564220
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10397333
69Oxytocin signaling pathway_Homo sapiens_hsa049211.09743980
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07929578
71Calcium signaling pathway_Homo sapiens_hsa040201.07494920
72Steroid biosynthesis_Homo sapiens_hsa001001.07451895
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06657904
74Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06249368
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04738116
76Arginine biosynthesis_Homo sapiens_hsa002201.04146482
77GnRH signaling pathway_Homo sapiens_hsa049121.01665276
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99688377
79Mismatch repair_Homo sapiens_hsa034300.98895407
80Arachidonic acid metabolism_Homo sapiens_hsa005900.98199070
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97357613
82Melanogenesis_Homo sapiens_hsa049160.95384842
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95231068
84DNA replication_Homo sapiens_hsa030300.92370370
85Estrogen signaling pathway_Homo sapiens_hsa049150.87820417
86Huntingtons disease_Homo sapiens_hsa050160.86560939
87Dilated cardiomyopathy_Homo sapiens_hsa054140.84241349
88Endometrial cancer_Homo sapiens_hsa052130.83963636
89Colorectal cancer_Homo sapiens_hsa052100.83619998
90Complement and coagulation cascades_Homo sapiens_hsa046100.81974596
91Tryptophan metabolism_Homo sapiens_hsa003800.80415861
92Type II diabetes mellitus_Homo sapiens_hsa049300.80153692
93Carbon metabolism_Homo sapiens_hsa012000.79085903
94Glioma_Homo sapiens_hsa052140.78614872
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78428210
96Protein export_Homo sapiens_hsa030600.74910784
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.73465899
98Tyrosine metabolism_Homo sapiens_hsa003500.72952347
99Base excision repair_Homo sapiens_hsa034100.72296934
100Non-homologous end-joining_Homo sapiens_hsa034500.71920014
101Butanoate metabolism_Homo sapiens_hsa006500.71361981
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71026239
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71024007
104cAMP signaling pathway_Homo sapiens_hsa040240.69771125
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.69359604
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68052603
107Renal cell carcinoma_Homo sapiens_hsa052110.67379596
108Bile secretion_Homo sapiens_hsa049760.66844745
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66836752
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.66361124
111Folate biosynthesis_Homo sapiens_hsa007900.66286786
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.65832056
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64655792
114Cell cycle_Homo sapiens_hsa041100.64624832
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63749741
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62227677
117TGF-beta signaling pathway_Homo sapiens_hsa043500.62225476
118Ras signaling pathway_Homo sapiens_hsa040140.61929385
119MAPK signaling pathway_Homo sapiens_hsa040100.61790882
120Phagosome_Homo sapiens_hsa041450.61787164
121Rheumatoid arthritis_Homo sapiens_hsa053230.61421692
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60882785
123Propanoate metabolism_Homo sapiens_hsa006400.59030137
124Chemokine signaling pathway_Homo sapiens_hsa040620.58125851
125Ovarian steroidogenesis_Homo sapiens_hsa049130.57747728
126Glycerolipid metabolism_Homo sapiens_hsa005610.57576330
127Thyroid hormone synthesis_Homo sapiens_hsa049180.57543989
128Fatty acid biosynthesis_Homo sapiens_hsa000610.57392151
129RNA transport_Homo sapiens_hsa030130.56839361
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55745100
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55541386
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55186939
133Insulin signaling pathway_Homo sapiens_hsa049100.54829805
134Spliceosome_Homo sapiens_hsa030400.54269957
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53482112
136Fatty acid metabolism_Homo sapiens_hsa012120.52408402
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51069152
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51025750
139Fatty acid elongation_Homo sapiens_hsa000620.50611294
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48453192
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.48364785
142Melanoma_Homo sapiens_hsa052180.48057368
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47939389
144Peroxisome_Homo sapiens_hsa041460.47241316
145Sulfur metabolism_Homo sapiens_hsa009200.46999006
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46976082
147Pancreatic cancer_Homo sapiens_hsa052120.46900595
148Vitamin B6 metabolism_Homo sapiens_hsa007500.44954692
149Metabolic pathways_Homo sapiens_hsa011000.44796640
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44527159
151Oocyte meiosis_Homo sapiens_hsa041140.44025659
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.41389824
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40998821
154Prolactin signaling pathway_Homo sapiens_hsa049170.40912605
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.39490396
156Choline metabolism in cancer_Homo sapiens_hsa052310.39126555
157VEGF signaling pathway_Homo sapiens_hsa043700.38980673
158Pyruvate metabolism_Homo sapiens_hsa006200.38264386
159Nitrogen metabolism_Homo sapiens_hsa009100.38143920
160Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37549685
161Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37454621
162Asthma_Homo sapiens_hsa053100.36428934
163Ether lipid metabolism_Homo sapiens_hsa005650.36057846
164Endocytosis_Homo sapiens_hsa041440.36026850
165Prion diseases_Homo sapiens_hsa050200.35902632
166Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35621974
167Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31287309
168Tight junction_Homo sapiens_hsa045300.26372335
169N-Glycan biosynthesis_Homo sapiens_hsa005100.25038879
170RNA degradation_Homo sapiens_hsa030180.24535253
171Homologous recombination_Homo sapiens_hsa034400.23703288
172Sphingolipid metabolism_Homo sapiens_hsa006000.23183440
173mRNA surveillance pathway_Homo sapiens_hsa030150.22181346
174Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22082208
175Sulfur relay system_Homo sapiens_hsa041220.21501909
176Glucagon signaling pathway_Homo sapiens_hsa049220.18522643
177beta-Alanine metabolism_Homo sapiens_hsa004100.18389416
178Pentose phosphate pathway_Homo sapiens_hsa000300.18262077
179Basal cell carcinoma_Homo sapiens_hsa052170.13333609
180Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12852618
181Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12174451
182Thyroid cancer_Homo sapiens_hsa052160.12095654

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