NT5DC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.82212705
2chromosome condensation (GO:0030261)9.67160098
3DNA packaging (GO:0006323)9.19100104
4microtubule depolymerization (GO:0007019)9.16847700
5sperm capacitation (GO:0048240)8.19450517
6spermatid nucleus differentiation (GO:0007289)7.85211376
7plasma membrane fusion (GO:0045026)7.62267751
8spermatid development (GO:0007286)7.14564546
9response to pheromone (GO:0019236)7.12481840
10microtubule polymerization or depolymerization (GO:0031109)7.02278693
11sperm-egg recognition (GO:0035036)6.85225300
12single strand break repair (GO:0000012)6.79411119
13multicellular organism reproduction (GO:0032504)6.30980362
14centriole replication (GO:0007099)6.29027909
15binding of sperm to zona pellucida (GO:0007339)6.27562766
16phosphatidylethanolamine biosynthetic process (GO:0006646)6.00397506
17reproduction (GO:0000003)5.80025566
18cell-cell recognition (GO:0009988)5.69354061
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.69190370
20calcium ion-dependent exocytosis (GO:0017156)5.63895344
21rRNA methylation (GO:0031167)5.56656690
22negative regulation of inclusion body assembly (GO:0090084)5.54467460
23phosphatidylethanolamine metabolic process (GO:0046337)5.52857659
24spermatogenesis (GO:0007283)5.43487581
25male gamete generation (GO:0048232)5.42340494
26centriole assembly (GO:0098534)5.35231197
27sexual reproduction (GO:0019953)5.28289143
28protein targeting to Golgi (GO:0000042)5.20700695
29protein polyglutamylation (GO:0018095)5.07379901
30establishment of protein localization to Golgi (GO:0072600)4.95541042
31gamete generation (GO:0007276)4.95148765
32regulation of centriole replication (GO:0046599)4.87213589
33microtubule severing (GO:0051013)4.86027482
34axonemal dynein complex assembly (GO:0070286)4.79707025
35retrograde transport, vesicle recycling within Golgi (GO:0000301)4.76273423
36regulation of cilium movement (GO:0003352)4.75366230
37rRNA modification (GO:0000154)4.71326677
38regulation of Rab GTPase activity (GO:0032313)4.69857382
39positive regulation of Rab GTPase activity (GO:0032851)4.69857382
40regulation of transcription involved in cell fate commitment (GO:0060850)4.17417034
41motile cilium assembly (GO:0044458)4.14263157
42cilium or flagellum-dependent cell motility (GO:0001539)4.07885365
43histone H3-K9 demethylation (GO:0033169)4.05682399
44single fertilization (GO:0007338)4.02086307
45germ cell development (GO:0007281)3.97363789
46multicellular organismal reproductive process (GO:0048609)3.93413379
47cellular process involved in reproduction in multicellular organism (GO:0022412)3.93132144
48cell wall macromolecule catabolic process (GO:0016998)3.92534108
49cellular ketone body metabolic process (GO:0046950)3.91687200
50nucleus organization (GO:0006997)3.90651501
51oxygen transport (GO:0015671)3.84313905
52RNA destabilization (GO:0050779)3.83629827
53regulation of inclusion body assembly (GO:0090083)3.82617184
54chromatin silencing (GO:0006342)3.77724049
55cell wall macromolecule metabolic process (GO:0044036)3.76359029
56gas transport (GO:0015669)3.76290919
57negative regulation of Rho protein signal transduction (GO:0035024)3.73489683
58regulation of histone H3-K27 methylation (GO:0061085)3.66650637
59regulation of T-helper 2 cell differentiation (GO:0045628)3.64392600
60regulation of microtubule-based movement (GO:0060632)3.57735442
61glycerol ether metabolic process (GO:0006662)3.53674725
62male meiosis (GO:0007140)3.53152254
63male meiosis I (GO:0007141)3.53116962
64ketone body metabolic process (GO:1902224)3.52176428
65peptidyl-threonine dephosphorylation (GO:0035970)3.50927212
66protein localization to Golgi apparatus (GO:0034067)3.49456650
67fertilization (GO:0009566)3.48703060
68protein depolymerization (GO:0051261)3.45457011
69DNA methylation involved in gamete generation (GO:0043046)3.42265385
70organic cation transport (GO:0015695)3.40658160
71DNA conformation change (GO:0071103)3.39552916
72nuclear pore complex assembly (GO:0051292)3.35915397
73regulation of somitogenesis (GO:0014807)3.24749241
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22927874
75ether metabolic process (GO:0018904)3.20967708
76histone exchange (GO:0043486)3.20399691
77negative regulation of histone methylation (GO:0031061)3.14155795
78meiosis I (GO:0007127)3.11693774
79multicellular organismal movement (GO:0050879)3.08730835
80musculoskeletal movement (GO:0050881)3.08730835
81seminiferous tubule development (GO:0072520)3.04253355
82piRNA metabolic process (GO:0034587)3.01333257
83microtubule nucleation (GO:0007020)2.98287585
84peptide catabolic process (GO:0043171)2.93696220
85resolution of meiotic recombination intermediates (GO:0000712)2.93496069
86synapsis (GO:0007129)2.93331824
87NAD biosynthetic process (GO:0009435)2.89567627
88response to acidic pH (GO:0010447)2.87165690
89Golgi to endosome transport (GO:0006895)2.84089601
90coenzyme catabolic process (GO:0009109)2.83409577
91polyamine biosynthetic process (GO:0006596)2.82029485
92sister chromatid segregation (GO:0000819)2.80257953
93homeostasis of number of cells within a tissue (GO:0048873)2.78261369
94cellular response to pH (GO:0071467)2.76932697
95cerebral cortex neuron differentiation (GO:0021895)2.76606526
96mitotic G1 DNA damage checkpoint (GO:0031571)2.74568971
97positive regulation of type 2 immune response (GO:0002830)2.74488204
98epithelial cilium movement (GO:0003351)2.68930789
99acrosome reaction (GO:0007340)10.9268772
100fusion of sperm to egg plasma membrane (GO:0007342)10.3147911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.42698134
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.45633399
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51168348
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.05124616
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.80075866
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.64163526
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.48076670
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42753981
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34000295
10BCL6_27268052_Chip-Seq_Bcells_Human2.09818271
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.09478836
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09478836
13RAC3_21632823_ChIP-Seq_H3396_Human2.06849634
14EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.04170665
15RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.03829481
16PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.99677507
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95368829
18YY1_22570637_ChIP-Seq_MALME-3M_Human1.95117762
19E2F1_20622854_ChIP-Seq_HELA_Human1.94373261
20NANOG_20526341_ChIP-Seq_ESCs_Human1.94233286
21ERA_21632823_ChIP-Seq_H3396_Human1.89744834
22BCOR_27268052_Chip-Seq_Bcells_Human1.88656625
23CBP_20019798_ChIP-Seq_JUKART_Human1.73335724
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73335724
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.69174145
26P300_27268052_Chip-Seq_Bcells_Human1.64292531
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63561746
28RUNX_20019798_ChIP-Seq_JUKART_Human1.63373968
29* GATA1_19941826_ChIP-Seq_K562_Human1.62195837
30SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62151225
31SMC4_20622854_ChIP-Seq_HELA_Human1.61795159
32SPI1_23127762_ChIP-Seq_K562_Human1.61721568
33TAF2_19829295_ChIP-Seq_ESCs_Human1.61436948
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60757184
35MYC_19829295_ChIP-Seq_ESCs_Human1.59621386
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.59466486
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.59394472
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.57855254
39OCT4_20526341_ChIP-Seq_ESCs_Human1.57128787
40PHF8_20622854_ChIP-Seq_HELA_Human1.56349919
41KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.53461647
42RBPJ_21746931_ChIP-Seq_IB4_Human1.52809904
43CTCF_20526341_ChIP-Seq_ESCs_Human1.50642321
44P68_20966046_ChIP-Seq_HELA_Human1.49730968
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49237992
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47789930
47ERG_20517297_ChIP-Seq_VCAP_Human1.47043956
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44922076
49SALL4_22934838_ChIP-ChIP_CD34+_Human1.42760558
50SPI1_20517297_ChIP-Seq_HL60_Human1.42637169
51ER_23166858_ChIP-Seq_MCF-7_Human1.41679172
52CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41552193
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40653811
54VDR_24787735_ChIP-Seq_THP-1_Human1.40444450
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.40243858
56CEBPB_22108803_ChIP-Seq_LS180_Human1.37550402
57LXR_22292898_ChIP-Seq_THP-1_Human1.36061018
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35280757
59SOX2_22085726_ChIP-Seq_NPCs_Mouse1.34958115
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34652317
61ETV1_20927104_ChIP-Seq_GIST48_Human1.33430158
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.33380041
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33267809
64P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.33118689
65FUS_26573619_Chip-Seq_HEK293_Human1.32745420
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.32420425
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.31677488
68GATA3_26560356_Chip-Seq_TH1_Human1.30239293
69TP63_22573176_ChIP-Seq_HFKS_Human1.29482420
70SMRT_27268052_Chip-Seq_Bcells_Human1.26675747
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25782664
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.20932777
73P53_21459846_ChIP-Seq_SAOS-2_Human1.15649042
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14547197
75GATA6_21074721_ChIP-Seq_CACO-2_Human1.14233637
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13862641
77CTCF_27219007_Chip-Seq_Bcells_Human1.13152790
78BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.13036123
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12166642
80NFYB_21822215_ChIP-Seq_K562_Human1.11328700
81OCT1_27270436_Chip-Seq_PROSTATE_Human1.11297580
82* GATA2_19941826_ChIP-Seq_K562_Human1.10949630
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.10145899
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10088054
85PHF8_20622853_ChIP-Seq_HELA_Human1.08105978
86STAT1_20625510_ChIP-Seq_HELA_Human1.07746421
87MYB_26560356_Chip-Seq_TH2_Human1.07111908
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06530760
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.03987238
90SA1_27219007_Chip-Seq_Bcells_Human1.03956154
91NCOR1_26117541_ChIP-Seq_K562_Human1.03316188
92TAF15_26573619_Chip-Seq_HEK293_Human1.03289949
93RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03061391
94FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01439526
95KLF5_25053715_ChIP-Seq_YYC3_Human1.00426833
96DROSHA_22980978_ChIP-Seq_HELA_Human0.99795213
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.98493414
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98230401
99FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96508994
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96230690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.12830009
2MP0003878_abnormal_ear_physiology6.12830009
3MP0003698_abnormal_male_reproductive4.04327939
4MP0001929_abnormal_gametogenesis3.84889762
5MP0005670_abnormal_white_adipose3.41805624
6MP0002132_abnormal_respiratory_system3.05416909
7MP0000678_abnormal_parathyroid_gland2.84389136
8MP0002161_abnormal_fertility/fecundity2.30053298
9MP0003718_maternal_effect2.25603421
10MP0005410_abnormal_fertilization10.4264170
11MP0005451_abnormal_body_composition1.94532055
12MP0002210_abnormal_sex_determination1.93152633
13MP0003011_delayed_dark_adaptation1.79159556
14MP0001485_abnormal_pinna_reflex1.73037446
15MP0001348_abnormal_lacrimal_gland1.70168816
16MP0005310_abnormal_salivary_gland1.66446105
17MP0003077_abnormal_cell_cycle1.63391871
18MP0001145_abnormal_male_reproductive1.58992616
19MP0004957_abnormal_blastocyst_morpholog1.57140058
20MP0002138_abnormal_hepatobiliary_system1.56920331
21MP0000653_abnormal_sex_gland1.50795974
22MP0002282_abnormal_trachea_morphology1.47725288
23MP0003724_increased_susceptibility_to1.45188182
24MP0003693_abnormal_embryo_hatching1.33835414
25MP0003646_muscle_fatigue1.30637928
26MP0008995_early_reproductive_senescence1.29192753
27MP0003436_decreased_susceptibility_to1.24032460
28MP0002234_abnormal_pharynx_morphology1.23045913
29MP0004742_abnormal_vestibular_system1.14302417
30MP0001545_abnormal_hematopoietic_system1.12846775
31MP0005397_hematopoietic_system_phenotyp1.12846775
32MP0002249_abnormal_larynx_morphology1.10511217
33MP0005248_abnormal_Harderian_gland1.09721079
34MP0004510_myositis1.08270310
35MP0001835_abnormal_antigen_presentation1.06922031
36MP0005083_abnormal_biliary_tract1.05888780
37MP0001486_abnormal_startle_reflex1.05564138
38MP0009115_abnormal_fat_cell1.04547709
39MP0009053_abnormal_anal_canal1.04537873
40MP0010094_abnormal_chromosome_stability1.00711573
41MP0002419_abnormal_innate_immunity0.99524452
42MP0008877_abnormal_DNA_methylation0.97052119
43MP0000685_abnormal_immune_system0.89791594
44MP0009764_decreased_sensitivity_to0.88161971
45MP0009697_abnormal_copulation0.88070020
46MP0001765_abnormal_ion_homeostasis0.86252046
47MP0009785_altered_susceptibility_to0.85677514
48MP0002723_abnormal_immune_serum0.84281432
49MP0002127_abnormal_cardiovascular_syste0.82524972
50MP0000313_abnormal_cell_death0.82396891
51MP0005025_abnormal_response_to0.81002596
52MP0001963_abnormal_hearing_physiology0.80332705
53MP0001800_abnormal_humoral_immune0.79489756
54MP0010307_abnormal_tumor_latency0.78106826
55MP0005395_other_phenotype0.76225301
56MP0008058_abnormal_DNA_repair0.75514095
57MP0002452_abnormal_antigen_presenting0.74496457
58MP0003303_peritoneal_inflammation0.74395953
59MP0001533_abnormal_skeleton_physiology0.74103529
60MP0003950_abnormal_plasma_membrane0.74085390
61MP0000015_abnormal_ear_pigmentation0.71740252
62MP0002722_abnormal_immune_system0.70020685
63MP0000566_synostosis0.69710624
64MP0002229_neurodegeneration0.67747985
65MP0005666_abnormal_adipose_tissue0.66799065
66MP0003111_abnormal_nucleus_morphology0.66554365
67MP0003172_abnormal_lysosome_physiology0.66361777
68MP0003699_abnormal_female_reproductive0.65226628
69MP0002398_abnormal_bone_marrow0.63065487
70MP0002420_abnormal_adaptive_immunity0.62985712
71MP0005636_abnormal_mineral_homeostasis0.62242680
72MP0001819_abnormal_immune_cell0.61766105
73MP0001968_abnormal_touch/_nociception0.60091952
74MP0009278_abnormal_bone_marrow0.58899480
75MP0000026_abnormal_inner_ear0.58760202
76MP0001790_abnormal_immune_system0.58488336
77MP0005387_immune_system_phenotype0.58488336
78MP0000703_abnormal_thymus_morphology0.58173283
79MP0004947_skin_inflammation0.57776871
80MP0000681_abnormal_thyroid_gland0.57150894
81MP0005000_abnormal_immune_tolerance0.56579019
82MP0008004_abnormal_stomach_pH0.54555409
83MP0006292_abnormal_olfactory_placode0.53615407
84MP0000371_diluted_coat_color0.52991270
85MP0005464_abnormal_platelet_physiology0.52924516
86MP0000716_abnormal_immune_system0.52250565
87MP0000249_abnormal_blood_vessel0.52231837
88MP0005164_abnormal_response_to0.50536994
89MP0002429_abnormal_blood_cell0.50508739
90MP0005379_endocrine/exocrine_gland_phen0.50040080
91MP0005671_abnormal_response_to0.49932167
92MP0002928_abnormal_bile_duct0.49745245
93MP0009765_abnormal_xenobiotic_induced0.47957100
94MP0003879_abnormal_hair_cell0.47701391
95MP0001119_abnormal_female_reproductive0.47301778
96MP0008469_abnormal_protein_level0.47097707
97MP0005253_abnormal_eye_physiology0.46664715
98MP0002405_respiratory_system_inflammati0.46578149
99MP0003828_pulmonary_edema0.46254390
100MP0005551_abnormal_eye_electrophysiolog0.45596744

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.56464808
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.10212756
3Absent/shortened dynein arms (HP:0200106)5.10212756
4Tubulointerstitial nephritis (HP:0001970)4.72509969
5Asymmetric septal hypertrophy (HP:0001670)4.62908873
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.41579448
7Attenuation of retinal blood vessels (HP:0007843)4.39314777
8Nasal polyposis (HP:0100582)4.33407467
9Aplasia/Hypoplasia of the earlobes (HP:0009906)4.28511077
10Bell-shaped thorax (HP:0001591)4.13870739
11Bony spicule pigmentary retinopathy (HP:0007737)4.05966077
12Resting tremor (HP:0002322)4.00478027
13Male infertility (HP:0003251)3.90284568
14Abnormal ciliary motility (HP:0012262)3.78607830
15Abnormal respiratory motile cilium physiology (HP:0012261)3.57862339
16Cone-rod dystrophy (HP:0000548)3.55926261
17Hypoplastic ischia (HP:0003175)3.50882782
18Abnormality of macular pigmentation (HP:0008002)3.38408870
19Hyperkalemia (HP:0002153)3.37427378
20Abnormal respiratory motile cilium morphology (HP:0005938)3.29495720
21Abnormal respiratory epithelium morphology (HP:0012253)3.29495720
22Abnormality of the nasal mucosa (HP:0000433)3.29045462
23Enlarged epiphyses (HP:0010580)3.26650186
24Abnormal rod and cone electroretinograms (HP:0008323)3.24233132
25Chronic hepatic failure (HP:0100626)3.13805386
26Infertility (HP:0000789)3.11585016
27Abnormal spermatogenesis (HP:0008669)3.08593457
28Impulsivity (HP:0100710)3.02877264
29Abnormality of the ischium (HP:0003174)2.97373490
30Azoospermia (HP:0000027)2.93638370
31Abnormal hemoglobin (HP:0011902)2.90138838
32Facial shape deformation (HP:0011334)2.80561168
33Potter facies (HP:0002009)2.80561168
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78375705
35Postural instability (HP:0002172)2.77389241
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72228659
37Hypochromic microcytic anemia (HP:0004840)2.66058008
38Flattened epiphyses (HP:0003071)2.62386818
39Duodenal stenosis (HP:0100867)2.51864784
40Small intestinal stenosis (HP:0012848)2.51864784
41Chronic obstructive pulmonary disease (HP:0006510)2.46135786
42Obstructive lung disease (HP:0006536)2.46135786
43Amelogenesis imperfecta (HP:0000705)2.42449824
44Abnormality of the costochondral junction (HP:0000919)2.37935103
45Absent epiphyses (HP:0010577)2.36213100
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.36213100
47Gastrointestinal infarctions (HP:0005244)2.33753820
48Truncal obesity (HP:0001956)2.31844225
49Osteomalacia (HP:0002749)2.31252456
50Hypoplasia of the thymus (HP:0000778)2.29640097
51Recurrent pneumonia (HP:0006532)2.29298868
52Abnormality of macrophages (HP:0004311)2.26111933
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25062028
54Aplasia/Hypoplasia of the thymus (HP:0010515)2.21053965
55Tetany (HP:0001281)2.19839875
56Hypoparathyroidism (HP:0000829)2.19174117
57Hypertensive crisis (HP:0100735)2.18436656
58Hyperthyroidism (HP:0000836)2.16446220
59Bowel incontinence (HP:0002607)2.11519233
60Hypoalphalipoproteinemia (HP:0003233)2.10398900
61Generalized aminoaciduria (HP:0002909)2.08889415
62Gingivitis (HP:0000230)2.08781702
63Menstrual irregularities (HP:0000858)2.08265920
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.06117321
65Abnormality of dental color (HP:0011073)2.05195096
66Abnormal large intestine physiology (HP:0012700)2.02581289
67Atelectasis (HP:0100750)2.01791462
68Decreased central vision (HP:0007663)1.99328592
69Tubulointerstitial abnormality (HP:0001969)1.99071446
70Progressive sensorineural hearing impairment (HP:0000408)1.98992441
71Recurrent bacterial skin infections (HP:0005406)1.95484033
72Portal hypertension (HP:0001409)1.95140005
73Recurrent abscess formation (HP:0002722)1.94241475
74Truncus arteriosus (HP:0001660)1.92518857
75Abnormality of the duodenum (HP:0002246)1.89733856
76Abnormal urine output (HP:0012590)1.88843533
77Vertebral clefting (HP:0008428)1.88515015
78Unilateral renal agenesis (HP:0000122)1.88117726
79Epiphyseal dysplasia (HP:0002656)1.87890644
80Abnormality of the preputium (HP:0100587)1.86332885
81Reticulocytosis (HP:0001923)1.85015595
82Widely patent fontanelles and sutures (HP:0004492)1.84866312
83Protuberant abdomen (HP:0001538)1.84827631
84Double outlet right ventricle (HP:0001719)1.84682151
85Congenital malformation of the right heart (HP:0011723)1.84682151
86Abnormality of DNA repair (HP:0003254)1.84190859
87Short ribs (HP:0000773)1.83159592
88Optic neuritis (HP:0100653)1.83030023
89Retrobulbar optic neuritis (HP:0100654)1.83030023
90Rhinitis (HP:0012384)1.82988742
91Horizontal nystagmus (HP:0000666)1.81138578
92Prolonged bleeding time (HP:0003010)1.80701878
93Upper limb muscle weakness (HP:0003484)1.77501554
94Abnormality of the hepatic vasculature (HP:0006707)1.76259034
95Seborrheic dermatitis (HP:0001051)1.75710417
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73836533
97Abnormality of potassium homeostasis (HP:0011042)1.73793402
98Chromsome breakage (HP:0040012)1.73440088
99Abnormality of the epiphysis of the femoral head (HP:0010574)1.73152874
100Optic nerve hypoplasia (HP:0000609)1.71367222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.17564967
2TESK14.67598854
3PNCK4.57484084
4DDR24.03330484
5INSRR3.20999547
6RIPK42.86988221
7PLK22.51829124
8MST1R2.50206716
9BRD42.44882859
10STK382.43387270
11KSR22.19670940
12BUB12.17349252
13MAP4K22.15465318
14CAMK1G1.80496170
15CDK121.73852218
16MAP3K21.73268561
17PTK2B1.73145357
18MAPK151.72737082
19WNK11.64956372
20WEE11.57641470
21CCNB11.48085331
22PDPK11.30630288
23CDK71.29929071
24PDK11.26966971
25STK38L1.24421086
26MET1.22454101
27PIK3CG1.21013040
28BLK1.17891398
29NEK11.16973157
30NEK21.16823432
31BRAF1.15045430
32BRSK21.14054139
33PRKD31.05212865
34TESK21.03221668
35BRSK11.01957468
36MAP3K81.01267203
37DYRK1B0.86723010
38MARK30.85343722
39NEK60.82578642
40JAK30.70753381
41IRAK40.68336775
42KSR10.64171135
43MAP3K30.61358921
44RPS6KA10.61256672
45EIF2AK10.60841745
46PRKG20.60573647
47RAF10.60322735
48PLK10.58899463
49ARAF0.57611666
50TNK20.55623500
51JAK20.54784783
52MAP3K10.53562740
53TTK0.52369009
54STK100.49578808
55CSF1R0.49576408
56WNK40.48825314
57BMX0.47471410
58PRKG10.46922116
59MAP2K30.45853419
60CSK0.44614569
61UHMK10.42519864
62CAMK1D0.42123843
63CDK10.39279926
64SYK0.38965113
65FGR0.38834071
66MAP3K110.38428674
67MAP3K70.36737900
68ROCK10.36231433
69CHEK10.35753488
70CDK40.35604056
71HCK0.35323840
72GRK60.35260924
73TYK20.34962644
74CDK20.34919626
75PRKAA20.34670143
76SIK20.34510985
77RPS6KA20.33162768
78RPS6KC10.32892650
79RPS6KL10.32892650
80TAOK10.32479001
81MAPK10.30969716
82NTRK30.29944620
83DYRK30.28657054
84RPS6KA60.28180879
85MUSK0.27414420
86YES10.26232820
87AKT30.25099718
88RET0.24416349
89PLK30.21093871
90RIPK10.19769280
91IKBKB0.19047130
92STK30.18835825
93SGK10.17657155
94CDK190.17493574
95GSK3B0.17145132
96STK390.16010483
97OXSR10.15880430
98BMPR20.15837895
99PRKCZ0.15753657
100LATS10.14431181

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.48319248
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.02208380
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.16933462
4Olfactory transduction_Homo sapiens_hsa047402.85972224
5Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.24050679
6Dorso-ventral axis formation_Homo sapiens_hsa043202.11660947
7Allograft rejection_Homo sapiens_hsa053302.09020197
8Antigen processing and presentation_Homo sapiens_hsa046122.00200774
9Glycerophospholipid metabolism_Homo sapiens_hsa005641.98258673
10Graft-versus-host disease_Homo sapiens_hsa053321.98045232
11Autoimmune thyroid disease_Homo sapiens_hsa053201.94550146
12Acute myeloid leukemia_Homo sapiens_hsa052211.91866913
13Type II diabetes mellitus_Homo sapiens_hsa049301.89888403
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88574605
15Influenza A_Homo sapiens_hsa051641.76501700
16RNA transport_Homo sapiens_hsa030131.68261733
17Type I diabetes mellitus_Homo sapiens_hsa049401.64259706
18Oocyte meiosis_Homo sapiens_hsa041141.61677503
19Leishmaniasis_Homo sapiens_hsa051401.60950115
20B cell receptor signaling pathway_Homo sapiens_hsa046621.56388178
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44880724
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44022254
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.43716596
24Fanconi anemia pathway_Homo sapiens_hsa034601.42270712
25Viral myocarditis_Homo sapiens_hsa054161.39562182
26Osteoclast differentiation_Homo sapiens_hsa043801.38047751
27Legionellosis_Homo sapiens_hsa051341.33719966
28Butanoate metabolism_Homo sapiens_hsa006501.21096231
29Herpes simplex infection_Homo sapiens_hsa051681.20989059
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20514373
31Cell cycle_Homo sapiens_hsa041101.06608730
32Measles_Homo sapiens_hsa051621.06529230
33Endocytosis_Homo sapiens_hsa041441.05444522
34VEGF signaling pathway_Homo sapiens_hsa043701.04927417
35Viral carcinogenesis_Homo sapiens_hsa052031.04326707
36Malaria_Homo sapiens_hsa051440.98038014
37Toxoplasmosis_Homo sapiens_hsa051450.96582167
38Staphylococcus aureus infection_Homo sapiens_hsa051500.95313150
39Non-small cell lung cancer_Homo sapiens_hsa052230.94625289
40Chemokine signaling pathway_Homo sapiens_hsa040620.93119802
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.92234755
42Epstein-Barr virus infection_Homo sapiens_hsa051690.88664329
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87343781
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86078461
45Taste transduction_Homo sapiens_hsa047420.85613074
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81355461
47Mismatch repair_Homo sapiens_hsa034300.80798612
48Prolactin signaling pathway_Homo sapiens_hsa049170.78755073
49Inositol phosphate metabolism_Homo sapiens_hsa005620.78063134
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76801350
51Fatty acid metabolism_Homo sapiens_hsa012120.76390560
52Tuberculosis_Homo sapiens_hsa051520.75275716
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74677390
54Estrogen signaling pathway_Homo sapiens_hsa049150.73863639
55Prostate cancer_Homo sapiens_hsa052150.72968368
56Fatty acid degradation_Homo sapiens_hsa000710.66585951
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66414873
58Homologous recombination_Homo sapiens_hsa034400.65148488
59Hepatitis B_Homo sapiens_hsa051610.63146328
60mRNA surveillance pathway_Homo sapiens_hsa030150.59239225
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58704350
62Phenylalanine metabolism_Homo sapiens_hsa003600.56597937
63ABC transporters_Homo sapiens_hsa020100.56572905
64Chronic myeloid leukemia_Homo sapiens_hsa052200.56292260
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53544639
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53465904
67Basal transcription factors_Homo sapiens_hsa030220.53201407
68ErbB signaling pathway_Homo sapiens_hsa040120.52230881
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49879391
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.49417665
71Pancreatic cancer_Homo sapiens_hsa052120.48953058
72Choline metabolism in cancer_Homo sapiens_hsa052310.48734494
73T cell receptor signaling pathway_Homo sapiens_hsa046600.47659489
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46972970
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44810868
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44188385
77mTOR signaling pathway_Homo sapiens_hsa041500.42913703
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42563565
79Regulation of autophagy_Homo sapiens_hsa041400.41832115
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40773522
81Hematopoietic cell lineage_Homo sapiens_hsa046400.40405207
82African trypanosomiasis_Homo sapiens_hsa051430.40236969
83MAPK signaling pathway_Homo sapiens_hsa040100.39862457
84FoxO signaling pathway_Homo sapiens_hsa040680.39854955
85TNF signaling pathway_Homo sapiens_hsa046680.39843387
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39547009
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.39340824
88Platelet activation_Homo sapiens_hsa046110.38604265
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38062820
90Selenocompound metabolism_Homo sapiens_hsa004500.38046403
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37946797
92HIF-1 signaling pathway_Homo sapiens_hsa040660.37649291
93Base excision repair_Homo sapiens_hsa034100.36639268
94Glycerolipid metabolism_Homo sapiens_hsa005610.36520881
95Mineral absorption_Homo sapiens_hsa049780.35166316
96cAMP signaling pathway_Homo sapiens_hsa040240.35091309
97Renal cell carcinoma_Homo sapiens_hsa052110.34803957
98Endometrial cancer_Homo sapiens_hsa052130.32122010
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.31979763
100Phagosome_Homo sapiens_hsa041450.31595893

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